{"id":109998,"date":"2019-04-11T00:00:50","date_gmt":"2019-05-17T09:35:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/109998\/"},"modified":"2019-05-17T17:35:52","modified_gmt":"2019-05-17T09:35:52","slug":"2970f2766a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/109998\/","title":{"rendered":"\u5168\u65b0\u7c7b\u578b\u964d\u7cd6\u836fIII\u671f\u4e34\u5e8a\u65d7\u5f00\u5f97\u80dc"},"content":{"rendered":"
\n

\"\u5168\u65b0\u7c7b\u578b\u964d\u7cd6\u836fIII\u671f\u4e34\u5e8a\u65d7\u5f00\u5f97\u80dc\"<\/a><\/p>\n

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\u6cd5\u56fdPoxel\u516c\u53f8\u7684\u4ee3\u8c22\u75c5\u4e13\u5bb6\u548c\u4ed6\u4eec\u7684\u4f4f\u53cb\uff08Sumitomo Dainippon\uff09\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u5728\u5b9e\u9a8c\u6027\u53e3\u670d\u7cd6\u5c3f\u75c5\u836fimeglimin\u7684\u9996\u9879\u540e\u671f\uff08\u65e5\u672c\uff09\u6d4b\u8bd5\u4e2d\u53d6\u5f97\u4e86\u5706\u6ee1\u6210\u529f\uff0c\u8fd9\u9884\u793a\u7740\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u5c06\u8981\u51fa\u7089\u7684\u4e00\u5bf9III\u671f\u8bd5\u9a8c\u524d\u666f\u4e5f\u5c06\u4e50\u89c2\uff0c\u71c3\u8d77\u4e86\u4eba\u4eec\u5bf9\u8fd9\u4e00\u7ebf\u7c92\u4f53\u6cbb\u7597\u836f\u7269\uff08mitochondrial therapy\uff09\u6210\u4e3a\u91cd\u78c5\u4ea7\u54c1\u7684\u9884\u671f\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u6587931\u5b57\uff0c\u7528\u65f62\u5206\u949f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u8bb8\u5173\u715c\u3001\u674e\u654f\u534e<\/span><\/p>\n

\u636e\u76f8\u5173\u5a92\u4f534\u67089\u65e5\u62a5\u9053\uff1a\u6cd5\u56fdPoxel\u516c\u53f8\u7684\u4ee3\u8c22\u75c5\u4e13\u5bb6\u548c\u4ed6\u4eec\u7684\u4f4f\u53cb\uff08Sumitomo Dainippon\uff09\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u5728\u5b9e\u9a8c\u6027\u53e3\u670d\u7cd6\u5c3f\u75c5\u836fimeglimin\u7684\u9996\u9879\u540e\u671f\uff08\u65e5\u672c\uff09\u6d4b\u8bd5\u4e2d\u53d6\u5f97\u4e86\u5706\u6ee1\u6210\u529f\uff0c\u8fd9\u9884\u793a\u7740\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u5c06\u8981\u51fa\u7089\u7684\u4e00\u5bf9III\u671f\u8bd5\u9a8c\u524d\u666f\u4e5f\u5c06\u4e50\u89c2\uff0c\u71c3\u8d77\u4e86\u4eba\u4eec\u5bf9\u8fd9\u4e00\u7ebf\u7c92\u4f53\u6cbb\u7597\u836f\u7269\uff08mitochondrial therapy\uff09\u6210\u4e3a\u91cd\u78c5\u4ea7\u54c1\u7684\u9884\u671f\u3002<\/span><\/p>\n

\u8be5\u836f\u7269\u5c5e\u4e8e\u4e00\u79cd\u65b0\u7684 \u201c\u683c\u5217\u654f\uff08glimins\uff09\u201d\u5316\u5b66\u7c7b\u578b\uff0c\u540d\u4e3aImeglimin\uff0c\u7cfb\u53e3\u670d\u7ed9\u836f\uff0c\u53ef\u540c\u65f6\u9488\u5bf9\u7cd6\u5c3f\u75c5\u6240\u6d89\u53ca\u7684\u4e09\u4e2a\u5173\u952e\u5668\u5b98\uff1a\u80f0\u817a\u3001\u809d\u810f\u548c\u808c\u8089\u3002Imeglimin\u9488\u5bf9II\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u4e24\u4e2a\u4e3b\u8981\u7f3a\u9677\uff1a\u901a\u8fc7\u4ee5\u8461\u8404\u7cd6\u4f9d\u8d56\u7684\u65b9\u5f0f\u589e\u52a0\u80f0\u817a\u4e2d\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\uff1b\u5e76\u901a\u8fc7\u51cf\u5c11\u809d\u810f\u8fc7\u91cf\u4ea7\u751f\u7684\u8461\u8404\u7cd6\uff0c\u540c\u65f6\u589e\u5f3a\u808c\u8089\u4e2d\u7684\u201c\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u201d\uff08\u589e\u52a0\u808c\u8089\u8461\u8404\u7cd6\u6444\u53d6\uff09\u4ea7\u751f\u6548\u679c\u3002\u5982\u679c\u83b7\u51c6\uff0cImeglimin\u5c06\u6210\u4e3a\u8fd9\u4e2a\u5168\u65b0\u7c7b\u578b\u964d\u7cd6\u836f\u4e2d\u7684\u9996\u4e2a\u3002<\/span><\/p>\n

\u8fd9\u9879TIMES 1\u8bd5\u9a8c\u5728213\u540d\u65e5\u672cII\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u5bf91000 mg\u5242\u91cfimeglimin\u4e0e\u5b89\u6170\u5242\u4f5c\u6bd4\u8f83\u3002\u8be5\u836f\u572824\u5468\u5185\u8bf1\u4f7fHbA1c\uff08\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff09\u2014\u2014\u5e73\u5747\u8840\u7cd6\u6c34\u5e73\u7edf\u8ba1\u5b66\u663e\u7740\u964d\u4f4e\uff08p <0.0001\uff09\uff0c\u8fbe\u5230\u4e3b\u8981\u76ee\u6807\u3002\u4e24\u5bb6\u516c\u53f8\u79f0\uff0c\u7ecf\u5b89\u6170\u5242\u6821\u6b63\u540eHbA1c\u4e0e\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u4e3a\u2013 0.87\uff05\u3002<\/span><\/p>\n

\u8be5\u836f\u8fd8\u8fbe\u5230\u4e86\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\u7684\u6700\u91cd\u8981\u7684\u6b21\u8981\u76ee\u6807\uff0c\u5e76\u4e14\u6b63\u5728\u8fdb\u884c\u5176\u5b83\u6b21\u8981\u7ec8\u70b9\u5206\u6790\u3002<\/span><\/p>\n

\u6839\u636e\u65e5\u7ecf\u6307\u6570\u5f15\u7528\u7684\u653f\u5e9c\u4f30\u8ba1\uff0c\u968f\u7740\u4eba\u53e3\u8001\u9f84\u5316\u548c\u80a5\u80d6\u7387\u7684\u4e0a\u5347\uff0c\u65e5\u672c\u7684\u7cd6\u5c3f\u75c5\u4eba\u6570\u6fc0\u589e\uff0c2016\u5e74\u9996\u6b21\u6000\u7591\u6709\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\u4eba\u6570\u8fbe\u5230\u521b\u7eaa\u5f55\u76841000\u4e07\u3002<\/span><\/p>\n

Poxel\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98Thomas Kuhn\u6258\u9a6c\u65af\u5e93\u6069\u8868\u793a\uff1a\u201cTIMES 1\u8bd5\u9a8c\u7ed3\u679c\u8bc1\u5b9e\u4e86\u5728\u65e5\u672c\u8fdb\u884c\u7684IIb\u671f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u5f3a\u5927\u6548\u679c\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4ee5\u53caImeglimin\u53ef\u4e3a\u5168\u7403II\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e26\u6765\u7684\u6f5c\u5728\u76ca\u5904\u3002\u201dTIMES 1\u8bd5\u9a8c\u6570\u636e\u662f\u5b9e\u73b02020\u5e74\u5728\u65e5\u672c\u63d0\u4ea4\u65b0\u836f\u7533\u8bf7\u7684\u7b2c\u4e00\u4e2a\u91cd\u8981\u6b65\u9aa4\u3002\u65e5\u672c\u662f\u7b2c\u4e8c\u5927II\u578b\u7cd6\u5c3f\u75c5\u5355\u4e00\u5e02\u573a\uff0c\u4ece\u5e7f\u4e49\u4e0a\u8bb2\uff0c\u4e9a\u6d32\u88ab\u8ba4\u4e3a\u5728\u5bf9\u4ed8\u672a\u6765\u7cd6\u5c3f\u75c5\u5927\u6d41\u884c\u65b9\u9762\u5904\u4e8e\u6700\u91cd\u8981\u5730\u7406\u4f4d\u7f6e\u3002<\/span><\/p>\n

2016\u5e74\uff0cPoxel\u516c\u53f8\u62a5\u9053\uff0c\u65e5\u672c\u7684\u4e00\u9879IIb\u671f\u8bd5\u9a8c\u91c7\u7528500 mg\uff0c1000 mg\u548c1500 mg\u5242\u91cf\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u4f7f\u8840\u7ea2\u86cb\u767dA1c\u5206\u522b\u964d\u4f4e0.52\uff05\uff0c0.94\uff05\u548c1.00\uff05\u3002<\/span><\/p>\n

\u968f\u540e\u7684TIMES-2\u548cTIMES-3\u4e24\u9879\u8bd5\u9a8c\u6570\u636e\u9884\u8ba1\u5c06\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u516c\u5e03\u3002\u53bb\u5e74\uff0cPoxel\u66fe\u7ecf\u5411Vivek Ramaswamy\u65d7\u4e0b\u7684Roivant\u79d1\u5b66\u516c\u53f8\u6388\u4e88imeglimin\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u7684\u6743\u5229\uff0c\u8be5\u5408\u4f5c\u4f19\u4f34\u627f\u8bfa\u8d44\u52a9\u9884\u8ba1\u5c06\u4e8e\u4eca\u5e74\u5f00\u59cb\u7684\u6602\u8d35\u7684III\u671f\u8ba1\u5212\u5927\u90e8\u5206\u7ecf\u8d39\u3002<\/span><\/p>\n

\u6570\u5bb6\u91d1\u878d\u6295\u8d44\u673a\u6784\u5206\u6790\u5e08\u8ba4\u4e3a\uff1aImeglimin\u4f5c\u4e3a\u7ebf\u7c92\u4f53\u751f\u7269\u80fd\u91cf\u589e\u5f3a\u5242\uff08mitochondrial bioenergetics enhancer\uff09\u5177\u6709\u5168\u65b0\u7684\u4f5c\u7528\u673a\u5236\uff0c\u53ef\u80fd\u5728\u7ade\u4e89\u6027II\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7597\u9886\u57df\u83b7\u5f97\u72ec\u7279\u7684\u5730\u4f4d\u3002\u534e\u5c14\u8857\u8457\u540d\u6295\u8d44\u94f6\u884c\u5206\u6790\u5e08\u7684\u7814\u7a76\u6a21\u578b\u9884\u6d4bimeglimin\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u4e9a\u6d32\u7684\u5546\u4e1a\u6210\u529f\u6982\u7387\u4e3a60\uff05\uff0c\u5168\u7403\u9500\u552e\u5cf0\u503c\u4f30\u8ba1\u4e3a31\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u5305\u62ec\u65e5\u672c\u76846\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\"\u5168\u65b0\u7c7b\u578b\u964d\u7cd6\u836fIII\u671f\u4e34\u5e8a\u65d7\u5f00\u5f97\u80dc\"<\/p>\n

\"\u5168\u65b0\u7c7b\u578b\u964d\u7cd6\u836fIII\u671f\u4e34\u5e8a\u65d7\u5f00\u5f97\u80dc\"<\/p>\n

\"\u5168\u65b0\u7c7b\u578b\u964d\u7cd6\u836fIII\u671f\u4e34\u5e8a\u65d7\u5f00\u5f97\u80dc\"<\/strong><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6cd5\u56fdPoxel\u516c\u53f8\u7684\u4ee3\u8c22\u75c5\u4e13\u5bb6\u548c\u4ed6\u4eec\u7684\u4f4f\u53cb\uff08Sumitomo Dainippon\uff09\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u5728\u5b9e\u9a8c […]<\/p>\n","protected":false},"author":1,"featured_media":109999,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/109998"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=109998"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/109998\/revisions"}],"predecessor-version":[{"id":110004,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/109998\/revisions\/110004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/109999"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=109998"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=109998"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=109998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}