{"id":110717,"date":"2019-05-19T00:00:50","date_gmt":"2019-05-20T01:07:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/110717\/"},"modified":"2019-05-20T09:07:32","modified_gmt":"2019-05-20T01:07:32","slug":"7186f78da8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/110717\/","title":{"rendered":"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76"},"content":{"rendered":"
\n

\u70b9\u51fb\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/span>\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong>\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n

\u516c\u4f17\u53f7\uff1ashiyan589<\/span><\/p>\n

\n
\n
\n

\u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u2193\u2193\u2193<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

<\/a><\/p>\n
<\/a><\/p>\n
\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/a><\/section>\n<\/section>\n<\/section>\n
<\/a><\/p>\n
<\/a><\/p>\n
\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/a><\/section>\n<\/section>\n<\/section>\n
<\/a><\/p>\n
<\/a><\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/a><\/p>\n<\/section>\n

\n
\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/a><\/p>\n<\/section>\n

\u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b<\/span><\/strong><\/p>\n

\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong>\u2193<\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n

<\/span><\/span>
<\/p>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

WX-0593\u7247\u662fALK\u6291\u5236\u5242\u3002<\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>ALK\/ROS1<\/span>\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u4e3b\u8981\u76ee\u7684\uff1a\u8bc4\u4ef7<\/span>WX-0593<\/span>\u7247\u53e3\u670d\u7ed9\u836f\u5728<\/span>ALK<\/span>\u6216<\/span>ROS1<\/span>\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u3002<\/span><\/span><\/p>\n

\u6b21\u8981\u76ee\u7684\uff1a\u8bc4\u4ef7<\/span>WX-0593<\/span>\u7247\u53e3\u670d\u7ed9\u836f\u5728<\/span>ALK<\/span>\u6216<\/span>ROS1<\/span>\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3002\u89c2\u5bdf<\/span>WX-0593<\/span>\u7247\u53e3\u670d\u7ed9\u836f\u5728<\/span>ALK<\/span>\u6216<\/span>ROS1<\/span>\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> II<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5355\u81c2\u8bd5\u9a8c<\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>   <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>     <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u5185\u8bd5\u9a8c<\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 176<\/span><\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u5e74\u9f84\u4e3a<\/span>18<\/span>\u5468\u5c81\u53ca\u4ee5\u4e0a\u3002<\/span><\/span><\/p>\n

2  <\/span>\u6027\u522b\uff1a\u7537\u5973\u4e0d\u9650\u3002<\/span><\/span><\/p>\n

3  ECOG <\/span>\u4f53\u80fd\u8bc4\u5206\u4e3a<\/span>0~2<\/span>\u5206\u3002<\/span><\/span><\/p>\n

4  <\/span>\u9884\u8ba1\u751f\u5b58\u671f\u4e0d\u5c11\u4e8e<\/span>12<\/span>\u5468\u3002<\/span><\/span><\/p>\n

5  <\/span>\u60a3\u8005\u5e94\u81f3\u5c11\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\u5b58\u5728\uff08<\/span>RECIST 1.1<\/span>\uff09\uff1b\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u653e\u7597\u7684\u75c5\u7076\uff0c\u53ea\u6709\u5f53\u8be5\u75c5\u7076\u653e\u7597\u540e\u6709\u660e\u786e\u7684\u8fdb\u5c55\u6307\u5f81\u65f6\uff0c\u624d\u53ef\u4ee5\u88ab\u8ba1\u4e3a\u9776\u75c5\u7076\u3002<\/span><\/span><\/p>\n

6  <\/span>\u4e09\u7ea7\u7532\u7b49\u533b\u9662\u6216\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u7ecf\u8fc7\u7ec4\u7ec7\u75c5\u7406\u5b66\u6216\u7ec6\u80de\u5b66\u68c0\u67e5\u8bc1\u5b9e\u7684<\/span>ALK<\/span>\u9633\u6027\u6216<\/span>ROS1<\/span>\u9633\u6027\u7684\u4ee5\u4e0b\u665a\u671f<\/span>NSCLC<\/span>\u60a3\u8005\uff1a\u65e2\u5f80\u7ecf\u514b\u5511\u66ff\u5c3c\u6301\u7eed\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\uff08\u6309\u7167<\/span>RECIST 1.1<\/span>\u6807\u51c6\uff09\u7684<\/span>ALK<\/span>\u9633\u6027<\/span>NSCLC<\/span>\u60a3\u8005\uff1b\u7ecf\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u540e\uff08\u5305\u62ec\u65e2\u5f80\u7ecf\u514b\u5511\u66ff\u5c3c\u6301\u7eed\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u8010\u53d7\u3001\u6216\u5316\u7597\u5931\u8d25\uff09\u7684<\/span>ROS1<\/span>\u9633\u6027<\/span>NSCLC<\/span>\u60a3\u8005\uff1b\u4e0d\u80fd\u63a5\u53d7\u5316\u7597\u7684<\/span>ROS1<\/span>\u9633\u6027<\/span>NSCLC<\/span>\u60a3\u8005\uff1b\u56e0\u7ecf\u6d4e\u539f\u56e0\u65e0\u6cd5\u63a5\u53d7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u7684<\/span>ROS1<\/span>\u9633\u6027<\/span>NSCLC<\/span>\u60a3\u8005\u3002<\/span><\/span><\/p>\n

7  <\/span>\u60a3\u8005\u5e94\u5c3d\u53ef\u80fd\u63d0\u4f9b\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u524d\u3001\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u5931\u8d25\u540e\u3001\u7814\u7a76\u836f\u7269\u6cbb\u7597\u5931\u8d25\u540e\u7684\u6d3b\u68c0\u7ec4\u7ec7\u6807\u672c\u6216\u5b58\u6863\u7684\u80bf\u7624\u7ec4\u7ec7\u6837\u672c\u3002<\/span><\/span><\/p>\n

8  <\/span>\u65e0\u8111\u8f6c\u79fb\u3001\u6216\u5b58\u5728\u65e0\u75c7\u72b6\u6027\u8111\u8f6c\u79fb\uff0c\u6216\u6709\u75c7\u72b6\u8111\u8f6c\u79fb\u7ecf\u8fc7\u6cbb\u7597\u7a33\u5b9a\u8d85\u8fc7<\/span>4<\/span>\u5468\uff0c\u5e76\u4e14\u5df2\u7ecf\u505c\u6b62\u5168\u8eab\u6027\u6fc0\u7d20\u6cbb\u7597\uff08\u5242\u91cf<\/span>>10mg\/<\/span>\u5929\u6cfc\u5c3c\u677e\u6216\u5176\u4ed6\u7b49\u7597\u6548\u6fc0\u7d20\uff09\u5927\u4e8e<\/span> 2 <\/span>\u5468\u3002<\/span><\/span><\/p>\n

9  <\/span>\u5668\u5b98\u7684\u529f\u80fd\u6c34\u5e73\u5fc5\u987b\u7b26\u5408\u4e0b\u5217\u8981\u6c42\uff08\u83b7\u5f97\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u524d<\/span>14<\/span>\u5929\u5185\u4e0d\u5141\u8bb8\u4f7f\u7528\u4efb\u4f55\u8840\u6db2\u6210\u5206\u3001\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u3001\u5347\u767d\u836f\u3001\u5347\u8840\u5c0f\u677f\u836f\u3001\u7ea0\u6b63\u8d2b\u8840\u836f\uff09\uff1a<\/span>ANC<\/span>\u2265<\/span>1.5<\/span>\u00d7<\/span>109\/L<\/span>\uff1b<\/span>PLT<\/span>\u2265<\/span>90<\/span>\u00d7<\/span>109\/L<\/span>\uff1b<\/span>Hb<\/span>\u2265<\/span>90 g\/L<\/span>\uff1b<\/span>TBIL<\/span>\u2264<\/span>1.5<\/span>\u00d7<\/span>ULN<\/span>\uff08\u5409\u4f2f\u7279\u6c0f\u75c7\u5019\u7fa4<\/span>TBIL<\/span>\u2264<\/span>3.0<\/span>\u00d7<\/span>ULN<\/span>\u4e14<\/span>DBIL<\/span>\u2264<\/span>1.5<\/span>\u00d7<\/span>ULN<\/span>\uff09\uff1b<\/span>ALT<\/span>\u548c<\/span>AST<\/span>\u2264<\/span>2.5<\/span>\u00d7<\/span>ULN<\/span>\uff1b\u5bf9\u4e8e\u6709\u809d\u8f6c\u79fb\u8005\uff0c<\/span>ALT<\/span>\u548c<\/span>AST<\/span>\u2264<\/span>5<\/span>\u00d7<\/span>ULN<\/span>\uff1b<\/span>Cr<\/span>\u2264<\/span>1.5<\/span>\u00d7<\/span>ULN<\/span>\uff1b<\/span>LVEF<\/span>\u2265<\/span>50%<\/span>\u3002<\/span><\/span><\/p>\n

10  <\/span>\u4efb\u4f55\u624b\u672f\u3001\u6240\u6709\u65e2\u5f80\u653e\u7597\uff08\u9664\u5916\u59d1\u606f\u6027\uff09<\/span>\/<\/span>\u64cd\u4f5c\u5fc5\u987b\u5728\u5f00\u59cb\u7814\u7a76\u836f\u7269\u6cbb\u7597\u524d\u81f3\u5c11<\/span>4<\/span>\u5468\u5df2\u5b8c\u6210\u3002\u59d1\u606f\u6027\u653e\u7597\u5fc5\u987b\u5728\u5f00\u59cb\u6cbb\u7597\u524d<\/span>48<\/span>\u5c0f\u65f6\u5df2\u5b8c\u6210\u3002<\/span><\/span><\/p>\n

11  <\/span>\u53d7\u8bd5\u8005\u7406\u89e3\u5e76\u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u65e2\u5f80\u4f7f\u7528\u8fc7\u514b\u5511\u66ff\u5c3c\u4ee5\u5916\u7684\u5176\u4ed6<\/span>ALK<\/span>\u6291\u5236\u5242\u7684\u60a3\u8005\u3002<\/span><\/span><\/p>\n

2  <\/span>\u80bf\u7624\u8111\u819c\u8f6c\u79fb\u60a3\u8005\u3002<\/span><\/span><\/p>\n

3  <\/span>\u9996\u6b21\u670d\u7528\u8bd5\u9a8c\u836f\u7269\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\u60a3\u6709\u4efb\u4f55\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u5fc3\u808c\u6897\u6b7b\u3001\u91cd\u5ea6<\/span>\/<\/span>\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3001\u51a0\u72b6\u52a8\u8109<\/span>\/<\/span>\u5916\u5468\u52a8\u8109\u65c1\u8def\u79fb\u690d\u3001\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u8111\u8840\u7ba1\u610f\u5916\uff08\u5305\u62ec\u77ed\u6682\u6027\u8111\u7f3a\u8840\u53d1\u4f5c\uff09\u3002<\/span><\/span><\/p>\n

4  <\/span>\u7b5b\u9009\u65f6<\/span>ECG<\/span>\u68c0\u67e5\u53d1\u73b0\u8fde\u7eed\u4e24\u6b21\u6821\u6b63\u7684<\/span>QT<\/span>\u95f4\u671f\uff08<\/span>QTc<\/span>\uff09<\/span>>480 ms<\/span>\uff0c\u5b58\u5728<\/span>NCI-CTCAE 4.03<\/span>\u5224\u5b9a\u2265<\/span>2 <\/span>\u7ea7\u7684\u5fc3\u5f8b\u5931\u5e38\uff0c\u2265<\/span>2 <\/span>\u7ea7\u7684\u5fc3\u529b\u8870\u7aed\uff0c\u4efb\u4f55\u5206\u7ea7\u7684\u623f\u98a4\u3001\u5ba4\u98a4\uff0c\u6216\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5ba4\u4e0a\u6027\u6216\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u9700\u8981\u6cbb\u7597\u6216\u5e72\u9884\u7684\u60a3\u8005\u3002<\/span><\/span><\/p>\n

5  <\/span>\u9996\u6b21\u670d\u7528\u8bd5\u9a8c\u836f\u7269\u524d<\/span>14<\/span>\u5929\u5185\u6216\u6cbb\u7597\u671f\u95f4\u9700\u8981\u5408\u5e76\u4f7f\u7528\u4efb\u4f55\u53ef\u80fd\u5ef6\u957f<\/span>QTc<\/span>\u95f4\u671f\u6216\u8bf1\u5bfc\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u7684\u836f\u7269\u3002<\/span><\/span><\/p>\n

6  <\/span>\u8fde\u7eed\u4f7f\u7528\u7c7b\u56fa\u9187\u6cbb\u7597\u8d85\u8fc7<\/span>30<\/span>\u5929\uff0c\u6216\u9700\u8981\u957f\u671f\u4f7f\u7528\u7c7b\u56fa\u9187\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<\/span><\/span><\/p>\n

7  <\/span>\u65e2\u5f80\u6216\u7528\u836f\u524d\u5b58\u5728\u5927\u9762\u79ef\u5f25\u6f2b\u6027<\/span>\/<\/span>\u53cc\u80ba\u95f4\u8d28\u7ea4\u7ef4\u5316\u75c5\u53f2\uff0c\u6216\u5df2\u77e5\u5206\u7ea7<\/span>3<\/span>\u6216<\/span>4<\/span>\u7ea7\u7684\u80ba\u95f4\u8d28\u7ea4\u7ef4\u5316\u6216\u95f4\u8d28\u6027\u80ba\u75c5\u53f2\uff0c\u5305\u62ec\u80ba\u708e\u3001\u8fc7\u654f\u6027\u80ba\u708e\u3001\u95f4\u8d28\u6027\u80ba\u708e\u3001\u95f4\u8d28\u6027\u80ba\u75c5\u3001\u95ed\u585e\u6027\u7ec6\u652f\u6c14\u7ba1\u708e\u548c\u80ba\u7ea4\u7ef4\u5316\u75c5\u53f2\uff0c\u4f46\u4e0d\u5305\u62ec\u5c40\u90e8\u653e\u5c04\u6027\u80ba\u708e\u6216\u653e\u5c04\u6027\u80ba\u7ea4\u7ef4\u5316\u75c5\u53f2\u3002<\/span><\/span><\/p>\n

8  <\/span>\u60a3\u8005\u5b58\u5728\uff1e<\/span>1<\/span>\u7ea7\u7684\u6076\u5fc3\u3001\u5455\u5410\u6216\u8179\u6cfb\uff08<\/span>CTCAE4.03<\/span>\u7248\uff09\uff0c\u5176\u4ed6\u80c3\u80a0\u9053\u529f\u80fd\u969c\u788d\u6216\u6709\u53ef\u80fd\u4f1a\u5f71\u54cd\u836f\u7269\u5438\u6536\u7684\u80c3\u80a0\u9053\u75be\u75c5\uff08\u4f8b\u5982\u6e83\u75a1\u6027\u75be\u75c5\u6216\u4e0d\u826f\u5438\u6536\u7efc\u5408\u75c7\uff09\u3002<\/span><\/span><\/p>\n

9  <\/span>\u53d7\u8bd5\u8005\u5728\u9996\u6b21\u670d\u7528\u8bd5\u9a8c\u836f\u7269\u524d\u4e00\u4e2a\u6708\u5185\u63a5\u53d7\u8fc7\u5176\u4ed6\u4e34\u5e8a\u7814\u7a76\u7684\u6cbb\u7597\uff08\u82e5\u7814\u7a76\u4e2d\u63a5\u53d7\u7684\u4e3a\u5df2\u4e0a\u5e02\u836f\u7269\uff0c\u5219\u9002\u7528\u4e8e\u6392\u9664\u6807\u51c6\u7b2c<\/span>12<\/span>\u6761\uff09\u3002<\/span><\/span><\/p>\n

10  <\/span>\u4e59\u809d\u8868\u9762\u6297\u539f\uff08<\/span>HBsAg<\/span>\uff09\u9633\u6027\u548c<\/span>\/<\/span>\u6216\u4e59\u809d\u6838\u5fc3\u6297\u4f53\uff08<\/span>HBcAb<\/span>\uff09\u9633\u6027\u4e14\u4e59\u809d\u75c5\u6bd2\u7684\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff08<\/span>HBVDNA<\/span>\uff09<\/span>>103copies\/mL<\/span>\u8005\uff0c\u6216\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u6297\u4f53\u9633\u6027\u8005\uff0c\u6216\u5df2\u77e5\u7684<\/span>HIV<\/span>\u611f\u67d3\u3002<\/span><\/span><\/p>\n

11  <\/span>\u5728\u53c2\u52a0\u672c\u7814\u7a76\u65f6\u8ddd\u79bb\u6700\u8fd1\u4e00\u6b21\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\uff08\u534a\u8870\u671f\u2264<\/span>3<\/span>\u5929\uff09\u4e0d\u8db3<\/span>2<\/span>\u5468\uff0c\u6216\u6700\u8fd1\u4e00\u6b21\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\uff08\u534a\u8870\u671f\ufe65<\/span>3<\/span>\u5929\uff09\u4e0d\u8db3<\/span>4<\/span>\u5468\uff0c\u5148\u524d\u670d\u7528\u514b\u5511\u66ff\u5c3c\u7684\u60a3\u8005\u53ef\u5728\u6700\u540e\u4e00\u6b21\u670d\u836f<\/span>1<\/span>\u5468\u540e\u63a5\u53d7<\/span>WX-0593<\/span>\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

12  <\/span>\u5728\u53c2\u52a0\u672c\u7814\u7a76\u81f3\u5c11<\/span>1<\/span>\u5468\u524d\u4e0d\u80fd\u4e2d\u65ad\u6216\u7814\u7a76\u671f\u95f4\u9700\u8981\u5408\u5e76\u4f7f\u7528<\/span>CYP3A4<\/span>\u7684\u5f3a\u8bf1\u5bfc\u5242\u6216\u5f3a\u6291\u5236\u5242\u7684\u60a3\u8005\uff0c\u6b64\u7c7b\u836f\u7269\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5361\u9a6c\u897f\u5e73\u3001\u82ef\u5df4\u6bd4\u59a5\u3001\u82ef\u59a5\u82f1\u3001\u5229\u798f\u5e03\u4e01\u3001\u5229\u798f\u5e73\u3001\u5229\u798f\u55b7\u6c40\u3001\u66ff\u62c9\u90a3\u97e6\u3001\u5229\u6258\u90a3\u97e6\u3001\u5723\u7ea6\u7ff0\u8349\u548c\u916e\u5eb7\u5511\u3002<\/span><\/span><\/p>\n

13  <\/span>\u5728\u53c2\u52a0\u672c\u7814\u7a76\u81f3\u5c11<\/span>1<\/span>\u5468\u524d\u4e0d\u80fd\u4e2d\u65ad\u6216\u5728\u7814\u7a76\u671f\u95f4\u9700\u8981\u670d\u7528\u4e3b\u8981\u7ecf<\/span>CYP3A4<\/span>\u4ee3\u8c22\u7684\u836f\u7269\uff0c\u4e14\u6cbb\u7597\u6307\u6570\u4f4e\u3002<\/span><\/span><\/p>\n

14  <\/span>\u598a\u5a20\u671f\u3001\u54fa\u4e73\u671f\u5973\u6027\u60a3\u8005\u6216\u6709\u751f\u80b2\u80fd\u529b\u5973\u6027\u7684\u57fa\u7ebf\u598a\u5a20\u8bd5\u9a8c\u68c0\u6d4b\u9633\u6027\u3002<\/span><\/span><\/p>\n

15  <\/span>\u5728\u6574\u4e2a\u8bd5\u9a8c\u671f\u95f4\u53ca\u8bd5\u9a8c\u7ed3\u675f\u540e<\/span>6<\/span>\u4e2a\u6708\u5185\u4e0d\u613f\u610f\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u7684\u80b2\u9f84\u5973\u6027\u60a3\u8005\u6216\u6709\u751f\u80b2\u8ba1\u5212\u7684\u7537\u6027\u60a3\u8005\u3002<\/span><\/span><\/p>\n

16  <\/span>\u6839\u636e\u7814\u7a76\u8005\u7684\u5224\u65ad\uff0c\u6709\u4e25\u91cd\u7684\u5371\u5bb3\u60a3\u8005\u5b89\u5168\u3001\u6216\u5f71\u54cd\u60a3\u8005\u5b8c\u6210\u7814\u7a76\u7684\u4f34\u968f\u75be\u75c5\uff08\u5982\u4e34\u5e8a\u4e0a\u4e0d\u53d7\u63a7\u5236\u7684\u9ad8\u8840\u538b\uff08\u8840\u538b<\/span>> 160\/110mmHg<\/span>\uff09\uff0c\u4e25\u91cd\u7684\u7cd6\u5c3f\u75c5\u3001\u7532\u72b6\u817a\u75be\u75c5\u7b49\uff09\u3002<\/span><\/span><\/p>\n

17  <\/span>\u6709\u5438\u6bd2\u3001\u9157\u9152\u7b49\u4e0d\u826f\u55dc\u597d\u3002\u9157\u9152\u6307\u6bcf\u5468\u996e\u7528<\/span>14<\/span>\u4e2a\u5355\u4f4d\u7684\u9152\u7cbe\uff1a<\/span>1<\/span>\u5355\u4f4d<\/span>=<\/span>\u5564\u9152<\/span>285mL<\/span>\uff0c\u6216\u70c8\u9152<\/span>25mL<\/span>\uff0c\u6216\u8461\u8404\u9152<\/span>100mL<\/span>\u3002<\/span><\/span><\/p>\n

18  <\/span>\u65e2\u5f80\u6709\u660e\u786e\u7684\u795e\u7ecf\u6216\u7cbe\u795e\u969c\u788d\u53f2\uff0c\u5305\u62ec\u766b\u75eb\u6216\u75f4\u5446\u3002<\/span><\/span><\/p>\n

19  <\/span>\u7b5b\u9009\u524d<\/span>3<\/span>\u5e74\u5185\u60a3\u6709\u5176\u4ed6\u6076\u6027\u80bf\u7624\u7684\u60a3\u8005\uff08\u6cbb\u6108\u7684\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\u3001\u5bab\u9888\u539f\u4f4d\u764c\u3001\u7532\u72b6\u817a\u539f\u4f4d\u764c\u3001\u7532\u72b6\u817a\u4e73\u5934\u72b6\u764c\u9664\u5916\uff09\u3002<\/span><\/span><\/p>\n

20  <\/span>\u6839\u636e\u7814\u7a76\u8005\u7684\u5224\u65ad\uff0c\u53ef\u80fd\u589e\u52a0\u7814\u7a76\u76f8\u5173\u7684\u98ce\u9669\u3001\u53ef\u80fd\u5e72\u6270\u5bf9\u7814\u7a76\u7ed3\u679c\u7684\u89e3\u91ca\u3001\u6216\u7814\u7a76\u8005\u548c<\/span>\/<\/span>\u6216\u7533\u529e\u8005\u8ba4\u4e3a\u4e0d\u9002\u5408\u5165\u7ec4\u7684\u60a3\u8005\u3002<\/span><\/span><\/p>\n


<\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u77f3\u8fdc\u51ef\uff0c\u533b\u5b66\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u6559\u6388 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7535\u8bdd <\/span><\/p>\n<\/td>\n

\n

010-87788293 <\/span><\/p>\n<\/td>\n

\n

Email <\/span><\/p>\n<\/td>\n

\n

syuankaipumc@126.com <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02\u671d\u9633\u533a\u6f58\u5bb6\u56ed\u5357\u91cc17\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

100021 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

<\/section>\n

\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

\u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"<\/p>\n


<\/p>\n

\"\u3010\u80ba\u764c-\u62db\u52df\u60a3\u8005\u3011\u6cbb\u7597ALK\u9633\u6027\/ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684II\u671f\u7814\u7a76\"\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c \u516c\u4f17\u53f7\uff1ashiyan589 \u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9 \u2193\u2193\u2193 \u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b \u2193\u2193\u2193\u2193 1. […]<\/p>\n","protected":false},"author":1,"featured_media":110718,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/110717"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=110717"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/110717\/revisions"}],"predecessor-version":[{"id":110727,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/110717\/revisions\/110727"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/110718"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=110717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=110717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=110717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}