{"id":110739,"date":"2019-05-19T00:00:50","date_gmt":"2019-05-20T01:07:36","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/110739\/"},"modified":"2019-05-20T09:07:38","modified_gmt":"2019-05-20T01:07:38","slug":"3c27e1b378","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/110739\/","title":{"rendered":"2019\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u4e28\u5b89\u8fdb\u3001\u7f57\u6c0f\u3001AZ\u7b49\u91cd\u78c5\u65b0\u836f\u8fdb\u5c55\u62a2\u5148\u770b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<section  class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;line-height: 25.6px;widows: 1;border-width: 0px;border-style: none;border-color: initial;font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;box-sizing: border-box;overflow-wrap: break-word 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!important;\">\u6295\u7a3f\u90ae\u7bb1\uff1ayiyao@yidu.sinanet.com<\/span><\/p>\n<p style=\"margin-bottom: 15px;max-width: 100%;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 11px;color: #8dadaa;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;overflow-wrap: break-word !important;\">\u25c6<\/strong><\/span><strong style=\"max-width: 100%;font-size: 11px;overflow-wrap: break-word !important;\"><span   style=\"max-width: 100%;color: #aa8dad;overflow-wrap: break-word !important;\">&nbsp;<\/span>&nbsp;<span style=\"max-width: 100%;color: #d85751;overflow-wrap: break-word !important;\">\u25c6<\/span><span style=\"max-width: 100%;color: #8dadaa;overflow-wrap: break-word !important;\">&nbsp;<\/span>&nbsp;<span style=\"max-width: 100%;color: #ece094;overflow-wrap: break-word 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\/><\/p>\n<p>\u6709\u5206\u6790\u5e08\u6307\u51fa\uff0c\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u7ed3\u679c\uff0c\u5c06\u4fc3\u4f7f\u5b89\u8fdb\u5728\u5236\u5b9a\u4e0b\u4e00\u6b65\u5f00\u53d1\u8ba1\u5212\u65f6\u4f18\u5148\u8003\u8651\u80ba\u764c\uff0c\u4ece\u957f\u8fdc\u6765\u770bAMG510\u7684\u672a\u6765\u53ef\u80fd\u662f\u591a\u79cd\u7ec4\u5408\u3002\u4e0a\u4e2a\u6708\uff0c\u5b89\u8fdb\u516c\u5e03\u5c06AMG510\u4e0e\u6297PD-1\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u7528\u836f\u7684\u8ba1\u5212\u3002\u5728KRAS\u9886\u57df\uff0c\u5b89\u8fdb\u53ef\u80fd\u9762\u4e34\u6765\u81eaMirati Therapeutics\u7684\u7ade\u4e89\uff0c\u540e\u8005\u4e5f\u6709\u4e00\u4e2a\u9776\u5411G12C\u7a81\u53d8KRAS\u86cb\u767d\u7684\u5019\u9009\u836f\u7269\uff0c\u5e76\u4e14\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u83b7\u5f97\u4e86\u51fa\u8272\u6570\u636e\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"width:100%;text-align:center;\" >\n<section style=\"display:inline-block;\">\n<section style=\"color: rgb(235, 103, 148);padding-right: 50px;padding-left: 50px;font-weight: bold;box-sizing: border-box;\" class=\"135brush\" >2\u3001\u7f57\u6c0f\u5e7f\u8c31\u6297\u764c\u836fentrectinib<\/section>\n<section style=\"margin-top:-6px;height:30px;\">\n<section style=\"width: 20px;height: 20px;border-radius: 100%;background: rgba(103, 147, 235, 0.9);opacity: 0.5;float: left;color: rgb(255, 255, 255);box-sizing: border-box;\"   ><\/section>\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(235, 103, 148);opacity: 0.5;float: left;margin-top: 2px;margin-left: -10px;color: rgb(255, 255, 255);box-sizing: border-box;\"><\/section>\n<section style=\"float:left;width:100%;margin-left:-42px;\" >\n<section style=\"padding-left: 23px;box-sizing: border-box;\">\n<section style=\"height: 11px;border-bottom: 1px dashed rgb(204, 204, 204);margin-left: 20px;box-sizing: border-box;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p>entrectinib\u5c5e\u4e8e\u201c\u80bf\u7624\u4e0d\u53ef\u77e5\u8bba\u201d\u5e7f\u8c31\u6297\u764c\u836f\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u9009\u62e9\u6027\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u9776\u5411\u6cbb\u7597\u643a\u5e26NTRK\uff08\u7f16\u7801TRK\uff09\u3001ROS1\u6216ALK1\u57fa\u56e0\u878d\u5408\u7684\u80bf\u7624\uff0c\u53ef\u4ee5\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\uff0c\u9488\u5bf9\u539f\u53d1\u6027\u548c\u8f6c\u79fb\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u80bf\u7624\u5747\u6709\u663e\u8457\u7597\u6548\uff0c\u6ca1\u6709\u4e0d\u826f\u8131\u9776\u6d3b\u6027\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u6b64\u6b21\u4f1a\u4e0a\uff0c\u5c06\u516c\u5e03\u4e00\u9879I\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u3002\u7814\u7a76\u5171\u5165\u7ec429\u4f8b\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u513f\u79d1\u60a3\u8005\uff0c\u5305\u62ec\u643a\u5e26NTRK\u3001ROS1\u6216ALK1\u57fa\u56e0\u878d\u5408\u7684\u5b9e\u4f53\u7624\u6216CNS\u80bf\u7624\uff0c\u4ee5\u53ca\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\uff08NBL\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c6\u4f8b\u57fa\u56e0\u878d\u5408CNS\u80bf\u7624\u4e2d\uff0c1\u4f8b\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u30013\u4f8b\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u30011\u4f8b\u672a\u786e\u8ba4\u7684PR\u30011\u4f8b\u5c1a\u672a\u8bc4\u4f30\u30026\u4f8b\u57fa\u56e0\u878d\u5408\u9885\u5916\u5b9e\u4f53\u7624\u4e2d\uff0c1\u4f8bCR\u30015\u4f8bPR\u300215\u4f8bNBL\u4e2d\uff0c1\u4f8b\u643a\u5e26ALK\u7a81\u53d8\uff08ALKF1174L\uff09\u7684\u60a3\u8005\u5b9e\u73b0CR\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u6240\u6709\u60a3\u8005\u4e2d\u4f4d\u6cbb\u7597\u65f6\u95f485\u5929\uff0c\u8fbe\u5230\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a57\u5929\u3002\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0centrectinib\u5728\u643a\u5e26NTRK\u3001ROS1\u6216ALK\u878d\u5408\u7684\u96be\u6cbb\u6027CNS\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u513f\u79d1\u60a3\u8005\u4e2d\u4ea7\u751f\u4e86\u663e\u8457\u3001\u5feb\u901f\u3001\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u603b\u7f13\u89e3\u7387\u8fbe100%\uff08n=11\/11\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u5f3a\u8c03\u4e86\u4eca\u5e74\u521d\u516c\u5e03\u7684I\/Ib\u7814\u7a76\u4e2d\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7f13\u89e3\u6570\u636e\uff0c\u4f46\u6709\u5206\u6790\u5e08\u6307\u51fa\uff0c\u4ecd\u9700\u5bc6\u5207\u5173\u6ce8entrectinib\u5df2\u77e5\u7684\u4f53\u91cd\u589e\u52a0\u526f\u4f5c\u7528\uff0c\u8fd9\u5bf9\u4e00\u4e9b\u60a3\u8005\u6765\u8bf4\u53ef\u80fd\u662f\u4e00\u4e2a\u91cd\u5927\u62c5\u5fe7\uff0c\u4e5f\u662f\u6295\u8d44\u8005\u91cd\u70b9\u5173\u6ce8\u7684\u95ee\u9898\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u76ee\u524d\uff0centrectinib\u6cbb\u7597NTRK\u878d\u5408\u5b9e\u4f53\u7624\u3001ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u65b0\u836f\u7533\u8bf7\u6b63\u5728\u63a5\u53d7\u7f8e\u56fdFDA\u5ba1\u67e5\uff0cPDUFA\u76ee\u6807\u65e5\u671f\u4e3a2018\u5e748\u6708\u4e2d\u65ec\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u53bb\u5e74\u5e95\uff0c\u62dc\u8033\u4e0eLoxo Oncology\u201c\u5e7f\u8c31\u201d\u9776\u5411\u6297\u764c\u836fVitrakvi\uff08larotrectinib\uff09\u83b7FDA\u6279\u51c6\u7528\u4e8e\u643a\u5e26NTRK\u57fa\u56e0\u878d\u5408\u665a\u671f\u5b9e\u4f53\u7624\uff0c\u6210\u4e3a\u83b7\u6279\u7684\u9996\u4e2a\u53e3\u670dTRK\u6291\u5236\u5242\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"width:100%;text-align:center;\" >\n<section style=\"display:inline-block;\">\n<section style=\"color: rgb(235, 103, 148);padding-right: 50px;padding-left: 50px;font-weight: bold;box-sizing: border-box;\" class=\"135brush\" >3\u3001MacroGenics\u516c\u53f8Fc\u7ed3\u6784\u57df\u6539\u826fHER2\u9776\u5411\u5355\u6297margetuximab<\/section>\n<section style=\"margin-top:-6px;height:30px;\">\n<section style=\"width: 20px;height: 20px;border-radius: 100%;background: rgba(103, 147, 235, 0.9);opacity: 0.5;float: left;color: rgb(255, 255, 255);box-sizing: border-box;\"   ><\/section>\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(235, 103, 148);opacity: 0.5;float: left;margin-top: 2px;margin-left: -10px;color: rgb(255, 255, 255);box-sizing: border-box;\"><\/section>\n<section style=\"float:left;width:100%;margin-left:-42px;\" >\n<section style=\"padding-left: 23px;box-sizing: border-box;\">\n<section style=\"height: 11px;border-bottom: 1px dashed rgb(204, 204, 204);margin-left: 20px;box-sizing: border-box;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p>margetuximab\uff08M\uff09\u662f\u4e00\u79cd\u65b0\u578b\u3001Fc\u7ed3\u6784\u57df\u4f18\u5316\u514d\u75ab\u589e\u5f3a\u7684\u6539\u826f\u7248HER2\u9776\u5411\u5355\u6297\uff0c\u5177\u6709\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\uff08\u8d6b\u8d5b\u6c40\uff09\u76f8\u4f3c\u7684HER2\u7ed3\u5408\u548c\u6297\u589e\u6b96\u4f5c\u7528\uff0c\u540c\u65f6\u5176\u4f18\u5316\u7684Fc\u7ed3\u6784\u57df\u80fd\u591f\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u7684\u53c2\u4e0e\u3002M\u4f18\u5316\u7684Fc\u7ed3\u6784\u57df\u589e\u52a0\u4e86\u5bf9\u6fc0\u6d3b\u578bFc\u53d7\u4f53\uff08FcR\uff09CD16A\u7684\u4eb2\u548c\u529b\uff0c\u5e76\u964d\u4f4e\u4e86\u5bf9\u6291\u5236\u578bFcR CD32B\u7684\u4eb2\u548c\u529b\u3002\u4f4e\u4eb2\u548c\u529bCD16A-158F\u7b49\u4f4d\u57fa\u56e0\u5df2\u77e5\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5176\u4ed6\u6297\u4f53\u7597\u6cd5\u964d\u4f4e\u7684\u4e34\u5e8a\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u3002\u76ee\u524d\uff0cM\u6b63\u5f00\u53d1\u7528\u4e8eHER2\u9633\u6027\u80bf\u7624\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u4eca\u5e74\u521d\u516c\u5e03\u7684HER2\u9633\u6027\u4e73\u817a\u764c\u5934\u5bf9\u5934III\u671f\u7814\u7a76SOPHIA\u663e\u793aM\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u76f8\u6bd4\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5177\u6709\u4f18\u52bf\uff0c\u4ece\u800c\u5f15\u53d1\u4e1a\u754c\u5bc6\u5207\u5173\u6ce8\u3002\u4e0d\u8fc7\u5f53\u65f6\u53ea\u662f\u516c\u5e03\u4e86\u98ce\u9669\u6bd4\uff08HR\uff09\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u6b64\u6b21\u4f1a\u4e0a\uff0c\u5c06\u516c\u5e03\u8be5\u7814\u7a76\u66f4\u4e3a\u8be6\u7ec6\u7684\u6570\u636e\u3002\u5728PFS\u65b9\u9762\uff0cM\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u76f8\u6bd4\u8868\u73b0\u51fa\u8fb9\u9645\u4f18\u52bf\uff085.8\u4e2a\u6708 vs 4.9\u4e2a\u6708\uff1bHR=0.76\uff0cp=0.033\uff09\u3002\u4f46\u5728\u56e0\u643a\u5e26CD16A-158F\u7b49\u4f4d\u57fa\u56e0\u7684\u63a2\u7d22\u6027\u4e9a\u7ec4\uff08\u536085%\uff09\u4e2d\uff0cmargetuximab\u8868\u73b0\u51fa\u4e86\u66f4\u5927\u7684\u4f18\u52bf\uff086.9\u4e2a\u6708 vs 5.1\u4e2a\u6708\uff1bHR=0.68\uff0cp=0.005\uff09\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u76ee\u524d\uff0cOS\u6570\u636e\u5c1a\u672a\u6210\u719f\u3002\u57fa\u4e8e158\u4f8b\u4e8b\u4ef6\uff0c\u5728\u6240\u6709\u60a3\u8005\u4e2d\uff0cM\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u76f8\u6bd4\u5c06\u4e2d\u4f4dOS\u63d0\u9ad81.7\u4e2a\u6708\uff0c\u800c\u5728\u643a\u5e26CD16A 158F\u7b49\u4f4d\u57fa\u56e0\u7684\u63a2\u7d22\u6027\u4e9a\u7ec4\u4e2d\u63d0\u9ad86.8\u4e2a\u6708\uff0c\u6700\u7ec8\u7684OS\u6570\u636e\u5206\u6790\u5c06\u57282020\u5e74\u5b8c\u6210\u3002\u6458\u8981\u6570\u636e\u53d1\u5e03\u540e\uff0cMacroGenics\u516c\u53f8\u80a1\u4ef7\u4e0a\u6da89%\u3002<\/p>\n<p><br  \/><\/p>\n<p>HER2\u9776\u70b9\u65b9\u9762\uff0c\u963f\u65af\u5229\u5eb7\u4e0e\u7b2c\u4e00\u4e09\u5171\u4e8e\u672c\u6708\u521d\u7b7e\u7f72\u4e86\u4e00\u9879\u9ad8\u8fbe69\u4ebf\u7f8e\u5143\u7684\u91cd\u5927\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09DS-8201\uff0c\u7528\u4e8e\u6cbb\u7597\u591a\u79cdHER2\u9633\u6027\u764c\u75c7\u4ee5\u53caHER2\u4f4e\u8868\u8fbe\u764c\u75c7\u3002DS-8201\u7531\u66f2\u59a5\u73e0\u5355\u6297\u4e0e\u65b0\u578b\u62d3\u6251\u5f02\u6784\u91761\u6291\u5236\u5242exatecan\u884d\u751f\u7269\u94fe\u63a5\u800c\u6210\uff0c\u53ef\u9776\u5411\u9012\u9001\u7ec6\u80de\u6bd2\u5236\u5242\u81f3\u8868\u8fbeHER2\u7684\u764c\u7ec6\u80de\u5185\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u672c\u6708\u521d\uff0c\u53cc\u65b9\u516c\u5e03HER2\u9633\u6027\u4e73\u817a\u764cII\u671f\u7814\u7a76DESTINY-Breast01\u7684\u6570\u636e\uff0c\u663e\u793aDS-8201\u4e09\u7ebf\u6cbb\u7597\u7597\u6548\u51fb\u8d25\u7f57\u6c0fKadcyla\uff08\u4e00\u79cdHER2\u9776\u5411ADC\uff0cado-\u66f2\u59a5\u73e0\u5355\u6297emtansine\uff09\uff0c\u5e76\u8bc1\u5b9e\u4e86I\u671f\u7814\u7a76DS8201-A-J101\u4e2d\u201c\u524d\u6240\u672a\u6709\u7684\u4e34\u5e8a\u6d3b\u6027\u201d\uff0c\u8be5\u9879I\u671f\u7814\u7a76\u663e\u793a\uff0c\u5728\u5e73\u5747\u5df2\u63a5\u53d77\u79cd\u7597\u6cd5\u6cbb\u7597\u5931\u8d25\u7684HER2\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0cDS-8201\u603b\u7f13\u89e3\u7387\u8fbe\u5230\u4e8660%\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"width:100%;text-align:center;\" >\n<section style=\"display:inline-block;\">\n<section style=\"color: rgb(235, 103, 148);padding-right: 50px;padding-left: 50px;font-weight: bold;box-sizing: border-box;\" class=\"135brush\" >4\u3001Nektar\u514d\u75ab\u523a\u6fc0\u7597\u6cd5NKTR-214<\/section>\n<section style=\"margin-top:-6px;height:30px;\">\n<section style=\"width: 20px;height: 20px;border-radius: 100%;background: rgba(103, 147, 235, 0.9);opacity: 0.5;float: left;color: rgb(255, 255, 255);box-sizing: border-box;\"   ><\/section>\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(235, 103, 148);opacity: 0.5;float: left;margin-top: 2px;margin-left: -10px;color: rgb(255, 255, 255);box-sizing: border-box;\"><\/section>\n<section style=\"float:left;width:100%;margin-left:-42px;\" >\n<section style=\"padding-left: 23px;box-sizing: border-box;\">\n<section style=\"height: 11px;border-bottom: 1px dashed rgb(204, 204, 204);margin-left: 20px;box-sizing: border-box;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p>\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5355\u836f\u7597\u6cd5\u5bf9\u5927\u591a\u6570\u8f6c\u79fb\u6027\u8089\u7624\u60a3\u8005\u7597\u6548\u5f88\u4f4e\u3002NKTR-214\u662f\u4e00\u79cdCD122\u504f\u5411IL-2\u901a\u8def\u6fc0\u52a8\u5242\uff0c\u80fd\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6269\u589e\u81ea\u7136\u6740\u6b7b\u7ec6\u80de\u548cCD8+T\u7ec6\u80de\u3002\u6765\u81eaI\/II\u671f\u7814\u7a76\u6570\u636e\u663e\u793a\uff0cNKTR-214\u8054\u5408\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u6297PD-1\u7597\u6cd5Opdivo\uff08NO\u7ec4\u5408\uff09\u5177\u6709\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u80bf\u7624\u7684\u7597\u6548\u3002<\/p>\n<p><br  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style=\"width:100%;text-align:center;\" >\n<section style=\"display:inline-block;\">\n<section style=\"color: rgb(235, 103, 148);padding-right: 50px;padding-left: 50px;font-weight: bold;box-sizing: border-box;\" class=\"135brush\" >6\u3001\u963f\u65af\u5229\u5eb7\/\u9ed8\u6c99\u4e1cPARP\u6291\u5236\u5242Lynparza\uff08\u5229\u666e\u5353\uff09<\/section>\n<section style=\"margin-top:-6px;height:30px;\">\n<section style=\"width: 20px;height: 20px;border-radius: 100%;background: rgba(103, 147, 235, 0.9);opacity: 0.5;float: left;color: rgb(255, 255, 255);box-sizing: border-box;\"   ><\/section>\n<section style=\"width: 15px;height: 15px;border-radius: 100%;background: rgb(235, 103, 148);opacity: 0.5;float: left;margin-top: 2px;margin-left: -10px;color: rgb(255, 255, 255);box-sizing: border-box;\"><\/section>\n<section style=\"float:left;width:100%;margin-left:-42px;\" >\n<section style=\"padding-left: 23px;box-sizing: border-box;\">\n<section style=\"height: 11px;border-bottom: 1px dashed rgb(204, 204, 204);margin-left: 20px;box-sizing: border-box;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p>\u79cd\u7cfbBRCA\u7a81\u53d8\uff08gBRCAm\uff09\u5bfc\u81f4\u7684\u53cc\u94feDNA\u65ad\u88c2\u4fee\u590d\u7f3a\u9677\u662f\u8f6c\u79fb\u6027\u80f0\u817a\u764c\uff08mPC\uff09\u7684\u4e00\u4e2a\u98ce\u9669\u56e0\u7d20\uff0c\u5b9a\u4e49\u4e86\u80f0\u817a\u764c\u7684\u4e00\u4e2a\u4e9a\u7fa4\u3002\u5728mPC\u4eba\u7fa4\u4e2d\uff0cgBRCAm\u7684\u53d1\u751f\u7387\u57284.5%\u5de6\u53f3\uff0c\u4f46\u5728\u67d0\u4e9bmPC\u4eba\u7fa4\uff08\u5982\u963f\u4ec0\u80af\u7eb3\u5179\u72b9\u592a\u4eba\uff0cAshkenazi Jews\uff09\u53ef\u80fd\u9ad8\u8fbe15%\u3002<\/p>\n<p><br  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136);\">\u53c2\u8003\u6765\u6e90\uff1a<\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1\u3001ASCO 2019 \u2013 Abstract drop fires the starting gun&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2\u3001Biotech in the spotlight as pharma takes back seat at ASCO<\/span><\/p>\n<section  class=\"\" style=\"max-width: 100%;line-height: 25.6px;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;box-sizing: border-box;\">\n<p style=\"margin-top: 10px;max-width: 100%;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: #C00000;overflow-wrap: break-word !important;\">\u63a8 \u8350&nbsp;\u9605 \u8bfb<\/span><\/strong><\/span><\/p>\n<\/section>\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;line-height: 25.6px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;overflow-wrap: break-word !important;\">\u25b7&nbsp;<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAxNjI5NzI4MA==&amp;mid=2247499526&amp;idx=1&amp;sn=f764bf83ea30343e8464e29a5ef1eae2&amp;chksm=9bf44329ac83ca3f7c7736c611cccfeaa50b699cd25896e2de7b16f22a0d3e50442b497f79b1&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u8fdb\u5165\u6536\u83b7\u671f\uff01\u6052\u745e\u5361\u745e\u5229\u73e0\u5355\u6297\u9012\u4ea4\u65b0\u4e0a\u5e02\u7533\u8bf7<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.6px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;overflow-wrap: break-word !important;\">\u25b7&nbsp;<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAxNjI5NzI4MA==&amp;mid=2247499526&amp;idx=3&amp;sn=0950bc19eeb7ea653b03e163cff6ac5f&amp;chksm=9bf44329ac83ca3f804e875801c15a63ceb517c001df0640d27b69361455d16680ffd4c9ac08&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u540c\u836f\u4e0d\u540c\u4ef7\uff1f4+7\u4ef7\u683c\u6d3c\u5730\u6210\u5f62 \u5168\u56fd\u8054\u52a8\u8d8b\u52bf\u663e\u73b0<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.6px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;overflow-wrap: break-word !important;\">\u25b7&nbsp;<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAxNjI5NzI4MA==&amp;mid=2247499501&amp;idx=1&amp;sn=7f407f8150e09a7656a276c0cd3604f6&amp;chksm=9bf442c2ac83cbd458db206d4f98e962d14a38cdd17cb0112d3de2f9dc823ce5e94effda3b5f&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u53e3\u670dDPP-4\u6291\u5236\u5242\u5e02\u573a\u683c\u5c40\uff1a\u77ed\u671f\u7206\u53d1\u5f0f\u589e\u957f 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