{"id":110867,"date":"2019-05-19T00:00:50","date_gmt":"2019-05-20T01:08:20","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/110867\/"},"modified":"2019-05-20T09:08:22","modified_gmt":"2019-05-20T01:08:22","slug":"40b5113b9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/110867\/","title":{"rendered":"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"xmteditor\" style=\"display:none;\"  ><\/section>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;text-align: justify;\">\u897f\u5170\u82b1\uff0c\u76f8\u4fe1\u662f\u5f88\u591a\u4eba\u5c0f\u65f6\u5019\u7684\u5669\u68a6\uff0c\u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u4e5f\u9010\u6e10\u63a5\u53d7\u5e76\u4e14\u7231\u4e0a\u5b83\u3002\u5927\u6982\u4eba\u5230\u4e2d\u5e74\u5c31\u662f \u201c\u4fdd\u6e29\u676f\u91cc\u6ce1\u67b8\u675e\uff0c\u9910\u684c\u5e38\u89c1\u897f\u5170\u82b1\u201d\u5427\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;text-align: justify;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558314501.jpeg\" alt=\"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7\" title=\"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7\"><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1aPixabay<\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0c\u4e24\u7bc7\u5173\u4e8e\u897f\u5170\u82b1\u7684\u7814\u7a76\u5907\u53d7\u77a9\u76ee\u3002\u9996\u5148\u662f\u7f8e\u56fd\u7ea6\u7ff0\u65af\u2022\u970d\u666e\u91d1\u65af\u5927\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u897f\u5170\u82b1\u5ae9\u82bd\u4e2d\u7684\u841d\u535c\u786b\u7d20\u6709\u52a9\u8c03\u8282\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u8111\u90e8\u51fa\u73b0\u7684\u67d0\u4e9b\u5316\u5b66\u5931\u8861\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><img class=\"\"     style=\"box-sizing: border-box;margin-right: auto;margin-left: auto;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;max-width: 600px;display: inline-block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558314501.png\" alt=\"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7\" title=\"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u53e6\u4e00\u9879\u7814\u7a76\u5219\u6765\u81ea\u4e8e\u54c8\u4f5b\u5927\u5b66\u8d1d\u65af\u4ee5\u8272\u5217\u5973\u6267\u4e8b\u533b\u7597\u4e2d\u5fc3\uff08Beth Israel Deaconess Medical Center\uff09\u3002\u8be5\u7814\u7a76\u8bc1\u5b9e\uff0c\u897f\u5170\u82b1\u7b49\u5341\u5b57\u82b1\u79d1\u690d\u7269\u4e2d\u542b\u6709\u4e00\u79cd\u5929\u7136\u5206\u5b50\uff0c\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u76f8\u5173\u7814\u7a76\u53d1\u8868\u5728\u300aScience\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><img class=\"\"     style=\"box-sizing: border-box;margin-right: auto;margin-left: auto;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;max-width: 600px;display: inline-block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558314502.jpg\" alt=\"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7\" title=\"\u54c8\u4f5b\u548c\u970d\u666e\u91d1\u65af\u5927\u5b66\u53cc\u201c\u7206\u6599\u201d\uff1a\u897f\u5170\u82b1\u7684\u6210\u5206\u6216\u8bb8\u771f\u80fd\u6297\u764c\uff0c\u8fd8\u80fd\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">DOI: 10.1126\/science.aau0159<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 15px;width: 0.6em;display: inline-block;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;width: 0.6em;height: 0.6em;display: block;opacity: 0.2;color: rgb(255, 255, 255);background-color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><span style=\"max-width: 100%;color: rgb(192, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"margin-top: 2px;margin-bottom: 2px;max-width: 100%;width: 0.6em;height: 0.6em;display: block;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><span style=\"max-width: 100%;width: 0.6em;height: 0.6em;display: block;opacity: 1;color: rgb(255, 255, 255);background-color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/section>\n<section style=\"padding-left: 10px;max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 15px;display: inline-block;vertical-align: middle;font-weight: 700;color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;color: rgb(192, 0, 0);letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/span><\/strong><\/section>\n<section class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;color: rgb(192, 0, 0);letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u529f\u6548\u4e00\uff1a\u9632\u6cbb\u7cbe\u795e\u5206\u88c2\u75c7<\/span><\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<p><br  \/><\/p>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u6570\u636e\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u5728\u5168\u4e16\u754c\u7684\u5f71\u54cd\u7ea6\u4e3a2100\u4e07\u4eba\u3002\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u7279\u5f81\u662f\u5e7b\u89c9\u3001\u5984\u60f3\u4ee5\u53ca\u601d\u7ef4\u3001\u611f\u89c9\u3001\u884c\u4e3a\u3001\u611f\u77e5\u548c\u8bf4\u8bdd\u7d0a\u4e71\u3002\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u836f\u7269\u5e76\u975e\u5bf9\u6240\u6709\u4eba\u90fd\u5b8c\u5168\u6709\u6548\uff0c\u5b83\u4eec\u53ef\u80fd\u5bfc\u81f4\u5404\u79cd\u4e0d\u826f\u526f\u4f5c\u7528\uff0c\u5305\u62ec\u4ee3\u8c22\u95ee\u9898\u589e\u52a0\u5fc3\u8840\u7ba1\u98ce\u9669\u3001\u65e0\u610f\u8bc6\u8fd0\u52a8\u3001\u5750\u7acb\u4e0d\u5b89\u3001\u50f5\u786c\u548c\u201c\u98a4\u6296\u201d\u7b49\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u66f4\u9ad8\u6548\u4e14\u4f4e\u526f\u4f5c\u7528\u7684\u65b0\u836f\u89e3\u51b3\u4ee5\u4e0a\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u300aJAMA Psychiatry\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u5bf9\u6bd4\u4e86\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u7ec4\u4e4b\u95f4\u5927\u8111\u4ee3\u8c22\u7684\u5dee\u5f02\u3002\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u5065\u5eb7\u4eba\u76f8\u6bd4\uff0c\u7cbe\u795e\u75c5\u60a3\u8005\u7684\u5927\u8111\u524d\u6263\u5e26\u76ae\u5c42\u533a\u57df\u7684\u8111\u5316\u5b66\u8c37\u6c28\u9178\u6c34\u5e73\u5e73\u5747\u8981\u4f4e4%\uff0c\u5927\u8111\u524d\u6263\u5e26\u76ae\u5c42\u4e2d\u7684\u8c37\u80f1\u7518\u80bd\u542b\u91cf\u663e\u8457\u964d\u4f4e\u4e863%\uff0c\u4e18\u8111\u4e2d\u7684\u8c37\u80f1\u7518\u80bd\u542b\u91cf\u663e\u8457\u964d\u4f4e\u4e868%\u3002\u800c\u8c37\u80f1\u7518\u80bd\u7531\u4e09\u4e2a\u8f83\u5c0f\u7684\u5206\u5b50\u7ec4\u6210\uff0c\u5176\u4e2d\u4e00\u4e2a\u662f\u8c37\u6c28\u9178\u3002\u4f17\u6240\u5468\u77e5\uff0c\u8c37\u6c28\u9178\u8d1f\u8d23\u8111\u7ec6\u80de\u95f4\u4fe1\u606f\u4f20\u9012\uff0c\u4e14\u88ab\u8ba4\u4e3a\u4e0e\u6291\u90c1\u75c7\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u6709\u5173\uff0c\u56e0\u6b64\u8fd9\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\u8c37\u6c28\u9178\u6c34\u5e73\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u53d1\u75c5\u8fc7\u7a0b\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u800c\u300aPNAS\u300b\u6742\u5fd7\u4e0a\u4e00\u9879\u5927\u9f20\u5b9e\u9a8c\u5219\u8868\u660e\uff0c\u5982\u679c\u6291\u5236\u8111\u90e8\u7684\u8c37\u6c28\u9178\u8f6c\u5316\u4e3a\u8c37\u80f1\u7518\u80bd\uff0c\u5927\u9f20\u8111\u7ec6\u80de\u4f1a\u5448\u73b0\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u5927\u8111\u7c7b\u4f3c\u7684\u6d3b\u8dc3\u72b6\u6001\u3002\u4f46\u5229\u7528\u841d\u535c\u786b\u7d20\u4fc3\u8fdb\u8c37\u6c28\u9178\u5411\u8c37\u80f1\u7518\u80bd\u8f6c\u5316\uff0c\u5927\u9f20\u8111\u7ec6\u80de\u72b6\u6001\u53c8\u8d8b\u4e8e\u6b63\u5e38\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7531\u4e8e\u841d\u535c\u786b\u7d20\u6539\u53d8\u4e86\u5927\u9f20\u5927\u8111\u4e2d\u7684\u8c37\u6c28\u9178\u5931\u8861\uff0c\u5f71\u54cd\u4e86\u4fe1\u606f\u5728\u5927\u9f20\u8111\u7ec6\u80de\u95f4\u7684\u4f20\u9012\u65b9\u5f0f\u3002\u4e8e\u662f\uff0c\u7814\u7a76\u4eba\u5458\u60f3\u8981\u6d4b\u8bd5\u841d\u535c\u786b\u7d20\u662f\u5426\u80fd\u6539\u53d8\u5065\u5eb7\u4eba\u5927\u8111\u4e2d\u7684\u8c37\u80f1\u7518\u80bd\u6c34\u5e73\uff0c\u770b\u770b\u8fd9\u6700\u7ec8\u662f\u5426\u80fd\u6210\u4e3a\u7cbe\u795e\u969c\u788d\u60a3\u8005\u7684\u4e00\u79cd\u7b56\u7565\u3002\u7ed3\u679c\u5bf9\u5065\u5eb7\u53d7\u8bd5\u8005\u7684\u7814\u7a76\u663e\u793a\uff0c\u670d\u7528\u5bcc\u542b\u841d\u535c\u786b\u7d20\u7684\u897f\u5170\u82b1\u5ae9\u82bd\u63d0\u53d6\u72697\u65e5\u540e\uff0c\u53d7\u8bd5\u8005\u5927\u8111\u4e2d\u7684\u8c37\u80f1\u7518\u80bd\u5e73\u5747\u6c34\u5e73\u5347\u9ad830%\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e0d\u8fc7\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u80fd\u5426\u5b89\u5168\u4f7f\u7528\u841d\u535c\u786b\u7d20\u4ee5\u53ca\u6700\u4f73\u4f7f\u7528\u5242\u91cf\u7b49\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u5b9e\u9a8c\u786e\u5b9a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 15px;width: 0.6em;display: inline-block;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;width: 0.6em;height: 0.6em;display: block;opacity: 0.2;color: rgb(255, 255, 255);background-color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><span style=\"max-width: 100%;color: rgb(192, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"margin-top: 2px;margin-bottom: 2px;max-width: 100%;width: 0.6em;height: 0.6em;display: block;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><span style=\"max-width: 100%;width: 0.6em;height: 0.6em;display: block;opacity: 1;color: rgb(255, 255, 255);background-color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/section>\n<section style=\"padding-left: 10px;max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 15px;display: inline-block;vertical-align: middle;font-weight: 700;color: rgb(214, 0, 74);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;color: rgb(192, 0, 0);letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/span><\/strong><\/section>\n<section class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;color: rgb(192, 0, 0);letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\">\u529f\u6548\u4e8c\uff1a\u6291\u5236\u80bf\u7624\u751f\u957f<\/span><\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<p><br  \/><\/p>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u636e\u4e86\u89e3\uff0cPTEN\u57fa\u56e0\u662f\u4eba\u7c7b\u80bf\u7624\u4e2d\u6700\u5e38\u89c1\u7684\u7a81\u53d8\u3001\u7f3a\u5931\u3001\u4e0b\u8c03\u6216\u6c89\u9ed8\u7684\u6291\u764c\u57fa\u56e0\u4e4b\u4e00\uff0c\u662f\u4e00\u79cd\u4f17\u6240\u5468\u77e5\u7684\u9ad8\u6548\u6291\u764c\u57fa\u56e0\u3002\u67d0\u4e9b\u9057\u4f20\u6027PTEN\u7a81\u53d8\u53ef\u5bfc\u81f4\u4ee5\u764c\u75c7\u6613\u611f\u6027\u548c\u53d1\u80b2\u7f3a\u9677\u4e3a\u7279\u5f81\u7684\u7efc\u5408\u5f81\u3002\u90a3\u4e48\u95ee\u9898\u5c31\u7b80\u5355\u4e86\uff0c\u5728\u764c\u75c7\u73af\u5883\u4e2d\uff0c\u628aPTEN\u6d3b\u6027\u6062\u590d\u5230\u6b63\u5e38\u6c34\u5e73\u662f\u4e0d\u662f\u5c31\u80fd\u91ca\u653e\u8be5\u57fa\u56e0\u7684\u6291\u764c\u6d3b\u6027\uff1f \u4e3a\u4e86\u627e\u5230\u8fd9\u4e00\u95ee\u9898\u7684\u7b54\u6848\uff0c\u8d1d\u65af\u4ee5\u8272\u5217\u5973\u6267\u4e8b\u533b\u7597\u4e2d\u5fc3\u7684Pier Paolo Pandolfi\u535a\u58eb\u548c\u4ed6\u7684\u540c\u4e8b\u5728\u764c\u75c7\u6613\u611f\u5c0f\u9f20\u6a21\u578b\u548c\u4eba\u7c7b\u7ec6\u80de\u4e2d\u8fdb\u884c\u4e00\u7cfb\u5217\u7684\u5b9e\u9a8c\uff0c\u901a\u8fc7\u514d\u75ab\u6c89\u6dc0\u548c\u8d28\u8c31\u5206\u6790\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u53eb\u505aWWP1\u7684\u57fa\u56e0\u4f1a\u4ea7\u751f\u4e00\u79cd\u9176\uff08E3\u6cdb\u7d20\u8fde\u63a5\u9176\uff09\uff0c\u6291\u5236PTEN\u7684\u6291\u764c\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6240\u4ee5\uff0c\u6291\u5236\u4e86WWP1\u4ea7\u751f\u7684\u8fd9\u4e2a\u9176\u662f\u4e0d\u662f\u5c31\u89e3\u9664\u4e86\u5bf9PTEN\u7684\u6291\u5236\uff1f\u7814\u7a76\u5c0f\u7ec4\u901a\u8fc7\u5206\u6790\u8fd9\u79cd\u9176\u7684\u7269\u7406\u5f62\u72b6\uff0c\u53d1\u73b0\u4e00\u79cd\u540d\u4e3a\u5432\u54da-3-\u7532\u9187(I3C)\u7684\u5c0f\u5206\u5b50\u53ef\u80fd\u662f\u6291\u5236WWP1\u81f4\u764c\u4f5c\u7528\u7684\u5173\u952e\u3002\u800cI3C\u662f\u897f\u5170\u82b1\u53ca\u5176\u5341\u5b57\u82b1\u79d1\u4eb2\u621a\u4e2d\u7684\u975e\u5e38\u5e38\u89c1\u4e00\u79cd\u6210\u5206\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u968f\u540e\uff0cPandolfi\u53ca\u5176\u540c\u4e8b\u901a\u8fc7\u7ed9\u764c\u75c7\u6613\u611f\u5c0f\u9f20\u6a21\u578b\u65bd\u7528I3C\u3002\u4e00\u4e2a\u6708\u8bd5\u9a8c\u53d1\u73b0\uff0c\u80bf\u7624\u4f53\u79ef\u663e\u8457\u7f29\u5c0f\u3002\u4e5f\u5c31\u662f\u8bf4\uff0cI3C\u662f\u771f\u7684\u80fd\u6291\u5236\u764c\u75c7\u7684\uff01\u56e0\u4e3aI3C\u53ef\u4ee5\u6291\u5236WWP1\u5bf9PTEN\u7684\u6cdb\u7d20\u5316\u4fee\u9970\uff0c\u4ece\u800c\u8ba9PTEN\u56de\u5230\u5b83\u5e94\u51fa\u73b0\u7684\u90e8\u4f4d\uff0c\u5b9e\u884c\u5b83\u5e94\u6709\u7684\u6291\u764c\u529f\u80fd\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u770b\u5230\u8fd9\u91cc\uff0c\u5404\u4f4d\u4e5f\u4e0d\u8981\u592a\u6fc0\u52a8\uff0c\u5c31\u60f3\u627f\u5305\u6574\u4e2a\u83dc\u573a\u7684\u897f\u5170\u82b1\u3002\u56e0\u4e3a\u201c\u6765\u6e90\u4e8e\u897f\u5170\u82b1\u7684\u5206\u5b50\u201d\u2260\u201c\u5403\u897f\u5170\u82b1\u201d\u3002\u8be5\u7814\u7a76\u7684\u7b2c\u4e00\u4f5c\u8005Yu-Ru Lee\u535a\u58eb\u4e5f\u6307\u51fa\uff0c\u5982\u679c\u8981\u6309\u7b49\u91cf\u6362\u7b97\uff0c\u8981\u8fbe\u5230\u6f5c\u5728\u7684\u6297\u764c\u6548\u679c\uff0c\u6bcf\u5929\u5927\u6982\u8981\u751f\u5403\u5c06\u8fd16\u65a4\u5341\u5b57\u82b1\u79d1\u852c\u83dc\uff0cemmm\uff0c\u663e\u7136\u662f\u4e0d\u592a\u73b0\u5b9e\u7684\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e0d\u8fc7\u522b\u62c5\u5fc3\uff0c\u79d1\u5b66\u5bb6\u4eec\u4f1a\u6cbf\u7740\u8fd9\u4e9b\u4f1f\u5927\u7684\u7814\u7a76\u6700\u7ec8\u5f00\u53d1\u51fa\u66f4\u6709\u6548\u7684WWP1\u6291\u5236\u5242\uff0c\u5b9e\u73b0\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u6291\u764c\u3002\u5c31\u50cfPandolfi\u6559\u6388\u6240\u8bf4\u201c\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u4e3a\u957f\u671f\u5bfb\u6c42\u764c\u75c7\u6cbb\u7597\u7684\u80bf\u7624\u6291\u5236\u518d\u6fc0\u6d3b\u65b9\u6cd5\u94fa\u5e73\u4e86\u9053\u8def\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e0d\u7ba1\u600e\u4e48\u8bf4\uff0c\u542c\u5988\u5988\u7684\u8bdd\uff0c\u591a\u5403\u70b9\u7eff\u8272\u852c\u83dc\u603b\u662f\u597d\u7684\u3002\u4e56\uff0c\u5e72\u4e86\u8fd9\u76d8\u897f\u5170\u82b1\u5427\uff01<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section  class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);caret-color: rgb(51, 51, 51);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;max-width: 100%;display: inline-block;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);caret-color: rgb(51, 51, 51);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[1]Broccoli sprout compound may restore brain chemistry imbalance linked to schizophrenia<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[2]Natural compound found in broccoli reawakens the function of potent tumor suppressor<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[3]Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;caret-color: rgb(51, 51, 51);font-size: 16px;color: rgb(62, 62, 62);line-height: 25.6px;border-width: 0px;border-style: none;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;color: inherit;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;overflow-wrap: break-word 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