{"id":110999,"date":"2019-05-18T00:00:50","date_gmt":"2019-05-20T01:18:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/110999\/"},"modified":"2019-05-20T09:18:04","modified_gmt":"2019-05-20T01:18:04","slug":"c02cb7e5c0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/110999\/","title":{"rendered":"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"rich_pages  __bg_gif\"      style=\"text-align: center;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558315083.gif\" alt=\"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565\" title=\"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565\"  \/><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u80ba\u764c\u662f\u5168\u7403\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u4e2d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7ea6\u5360 85%\uff0c\u5927\u90e8\u5206 NSCLC \u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u7ecf\u5904\u4e8e\u665a\u671f\uff0c\u5e78\u8fd0\u7684\u662f\u5728\u4e1c\u4e9a\u80ba\u817a\u764c\u60a3\u8005\u4e2d\uff0cEGFR \u57fa\u56e0\u7a81\u53d8\u7387\u9ad8\u8fbe 50% \u5de6\u53f3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u76ee\u524d\uff0cEGFR-TKIs \u5df2\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e EGFR \u654f\u611f\u7a81\u53d8\u7684\u665a\u671f NSCLC \u60a3\u8005\uff0c\u5e76\u660e\u663e\u5ef6\u957f\u4e86\u8be5\u7c7b\u60a3\u8005\u7684\u751f\u5b58\u65f6\u95f4\u3002\u7136\u800c\uff0c\u5728\u63a5\u53d7\u4e00\u6bb5\u65f6\u95f4\u7684 EGFR TKIs \u6cbb\u7597\u540e\uff0c\u51e0\u4e4e\u6240\u6709\u7684\u60a3\u8005\u90fd\u4e0d\u53ef\u907f\u514d\u5730\u51fa\u73b0\u8010\u836f\u3002\u4eca\u5929\u6211\u4eec\u5c31\u6765\u8be6\u7ec6\u4e86\u89e3\u4e0b EGFR TKIS \u7684\u8010\u836f\u673a\u5236\u53ca\u5176\u8010\u836f\u540e\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"    style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;width: 677px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;line-height: 30px;height: 30px;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c\u4e00\u3001\u4e8c\u4ee3 EGFR-TKI \u7684\u83b7\u5f97\u6027\u8010\u836f\u673a\u5236<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c\u4e00\u4ee3 EGFR-TKI \u662f\u53ef\u9006\u6027\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0cEGFR \u57fa\u56e0\u7a81\u53d8\u9633\u6027\u60a3\u8005\u4e2d\u53ef\u83b7\u5f97\u7ea6 10 \u4e2a\u6708\u7684\u4e2d\u4f4d PFS\uff0c\u4f46\u7ec8\u5f52\u4f1a\u53d1\u751f\u83b7\u5f97\u6027\u8010\u836f\uff0c\u5176\u91cd\u8981\u5206\u5b50\u673a\u5236\u662f EGFR \u57fa\u56e0 20 \u53f7\u5916\u663e\u5b50 T790M \u7a81\u53d8\uff0c\u76ee\u524d\u56fd\u5185\u53ef\u4ee5\u83b7\u5f97\u7684\u7b2c\u4e00\u4ee3 EGFR-TKI \u5305\u62ec\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u548c\u57c3\u514b\u66ff\u5c3c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c\u4e8c\u4ee3 EGFR-TKI \u836f\u7269\u7684\u7814\u53d1\u601d\u8def\u662f\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u836f\u7269\u4e0e ErbB \u53d7\u4f53\u7f51\u7edc\u5f62\u6210\u5171\u4ef7\u7ed3\u5408\uff0c\u4ece\u800c\u4e0d\u53ef\u9006\u5730\u3001\u5b8c\u5168\u4e2d\u65ad\u4fe1\u53f7\u4f20\u5bfc\uff0c\u4ece\u800c\u5e26\u6765\u6301\u7eed\u4e14\u5e7f\u8c31\u7684\u6297\u764c\u6d3b\u6027\u3002\u5176\u4ee3\u8868\u836f\u7269\u4e3a\u963f\u6cd5\u66ff\u5c3c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u901a\u8fc7\u4e8c\u6b21\u7ec4\u7ec7\u6d3b\u68c0\uff0c\u5927\u7ea6\u53ef\u4ee5\u660e\u786e 60%\uff5e70% \u63a5\u53d7 EGFR TKI \u6cbb\u7597\u60a3\u8005\u7684\u83b7\u5f97\u6027\u8010\u836f\u673a\u5236\u3002\u603b\u4f53\u800c\u8a00, \u4e00\u3001\u4e8c\u4ee3 EGFR-TKIS \u7684\u83b7\u5f97\u6027\u8010\u836f\u673a\u5236\u4e3b\u8981\u53ef\u5206\u4e3a\u4ee5\u4e0b\u56db\u7c7b:<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 15px;margin-left: 15px;max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1. EGFR \u901a\u8def\u51fa\u73b0\u4e86\u4e8c\u6b21\u7a81\u53d8\uff0c\u6700\u5e38\u89c1\u7684\u662f T790M \u7a81\u53d8\uff0c\u7ea6\u5360\u8010\u836f\u60a3\u8005\u7684 50% \u5de6\u53f3\uff1b<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 15px;margin-left: 15px;max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2. \u65c1\u8def\u6216\u8005\u4e0b\u6e38\u901a\u8def\u6fc0\u6d3b\uff0c\u5982 MET \u6269\u589e\u3001Her2 \u6269\u589e\u3001PI3K\/AKT \u901a\u8def\u6d3b\u5316\u3001\u4e0e IGF1R \u901a\u8def\u7684\u4ea4\u4e92\u4f5c\u7528\u3001 FGFR1 \u6fc0\u6d3b\u3001 BRAF \u7a81\u53d8\u7b49;<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 15px;margin-left: 15px;max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3. \u7ec4\u7ec7\u6216\u8005\u8868\u578b\u8f6c\u5316\uff0c\u5982\u817a\u764c\u5411\u5c0f\u7ec6\u80de\u80ba\u764c\u8f6c\u5316, \u4e0a\u76ae\u7ec6\u80de\u5411\u95f4\u53f6\u7ec6\u80de\u8f6c\u5316\uff1b<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 15px;margin-left: 15px;max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">4. \u836f\u7406\u5b66\u7684\u539f\u56e0, \u5982\u56e0\u4e3a\u836f\u7269\u7684\u8840\u8111\u5c4f\u969c\u900f\u8fc7\u7387\u4f4e\u5bfc\u81f4\u8111\u8f6c\u79fb\u3002<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"    style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;width: 677px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;line-height: 30px;height: 30px;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c\u4e09\u4ee3 EGFR-TKI \u8010\u836f\u673a\u5236\u7814\u7a76\u8fdb\u5c55<\/span><\/section>\n<\/section>\n<\/section>\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ee5\u5965\u5e0c\u66ff\u5c3c\u4e3a\u4ee3\u8868\u7684\u7b2c\u4e09\u4ee3 EGFR-TKI \u7684\u51fa\u73b0\u4e3a\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u8010\u836f\u6cbb\u7597\u5e26\u6765\u4e86\u66d9\u5149\uff0c2017 \u5e74\uff0c\u5965\u5e0c\u66ff\u5c3c\uff08\u5546\u54c1\u540d: \u6cf0\u745e\u6c99\uff09\u5728\u4e2d\u56fd\u6b63\u5f0f\u4e0a\u5e02\uff0c\u5bf9\u4e8e\u63a5\u53d7\u7b2c\u4e00\u4ee3\u9776\u5411\u836f\u6cbb\u7597\u53d1\u751f\u8010\u836f\u7684 EGFR T790M \u7a81\u53d8\u7684\u665a\u671f\u80ba\u764c\u60a3\u8005\u6765\u8bf4\u6709\u4e86\u65b0\u9009\u62e9\u3002\u7136\u800c\u5927\u90e8\u5206\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u75be\u75c5\u8fdb\u5c55\u671f\u7ea6 10-12 \u4e2a\u6708\uff0c\u6b64\u540e\u4fbf\u4f1a\u51fa\u73b0\u8010\u836f\uff0c\u5bfc\u81f4\u75be\u75c5\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u79d1\u5b66\u9886\u57df\u5bf9\u5965\u5e0c\u66ff\u5c3c\u7684\u8010\u836f\u673a\u5236\u7814\u7a76\u66f4\u4e3a\u6df1\u5165\u3002\u76ee\u524d\u6765\u770b\uff0c\u5965\u5e0c\u66ff\u5c3c\u7684\u8010\u836f\u673a\u5236\u4e3b\u8981\u5206\u4e3a 3 \u5927\u7c7b\uff1a<span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">EGFR \u57fa\u56e0\u4e0a\u53c8\u4ea7\u751f\u65b0\u7684\u7a81\u53d8\uff0c\u5176\u4ed6\u57fa\u56e0\u53d1\u751f\u4e86\u53d8\u5f02\uff0c\u8f6c\u5316\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/strong><\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"    style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: flex;justify-content: flex-start;align-items: flex-end;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 1.8em;text-align: center;height: 1.8em;line-height: 1.8em;font-size: 18px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);border-radius: 100%;overflow-wrap: break-word !important;\">0<span class=\"\"  title=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1<\/span><\/section>\n<section style=\"margin-bottom: 0.25em;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);border-top-color: rgb(61, 170, 214);border-left-color: rgb(61, 170, 214);border-right-color: rgb(61, 170, 214);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f9d\u8d56 EGFR \u901a\u8def<\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u53d1 EGFR \u7a81\u53d8\uff1a<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">EGFR-C797S \u7a81\u53d8\u662f\u5bfc\u81f4\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u6700\u5e38\u89c1\u7684\u7ee7\u53d1\u7a81\u53d8\u3002C797S \u662f EGFR20 \u53f7\u5916\u663e\u5b50 797 \u4f4d\u70b9\u4e0a\u4e1d\u6c28\u9178\u53d6\u4ee3\u4e86\u534a\u80f1\u6c28\u9178\u7684\u9519\u4e49\u7a81\u53d8\uff0c\u4f4d\u4e8e EGFR \u7684\u916a\u6c28\u9178\u6fc0\u9176\u533a, C797S \u7684\u7a81\u53d8\u4f7f\u5f97\u5965\u5e0c\u66ff\u5c3c\u65e0\u6cd5\u5728 ATP \u7ed3\u5408\u57df\u5185\u7ee7\u7eed\u5f62\u6210\u5171\u4ef7\u952e\uff0c\u4ece\u800c\u5931\u53bb\u6291\u5236 EGFR \u6fc0\u6d3b\u7684\u6548\u679c\uff0c\u5bfc\u81f4\u8010\u836f\u7684\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u987a\u5f0f\u7a81\u53d8\uff1aEGFR C797S \u7a81\u53d8\u4e0e T790M \u7a81\u53d8\u4e3b\u8981\u5448\u987a\u5f0f\u6784\u578b\uff08\u5373\u4f4d\u4e8e\u540c\u4e00\u6761\u67d3\u8272\u4f53\u4e0a\uff09, \u5360 85% , \u5bf9\u76ee\u524d\u83b7\u6279\u7684 EGFR-TKIs \u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u5747\u8010\u836f\uff1b<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53cd\u5f0f\u7a81\u53d8\uff1a\u7ea6 10% \u60a3\u8005\u4e3a C797S\/T790M \u53cd\u5f0f\u6784\u578b\uff08\u5373\u4f4d\u4e8e\u4e0d\u540c\u67d3\u8272\u4f53\u4e0a\uff09, \u80bf\u7624\u7ec6\u80de\u5bf9\u5965\u5e0c\u66ff\u5c3c\u8010\u836f, \u4f46\u5bf9\u7b2c\u4e00\u4ee3 EGFR-TKIs \u548c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u6cbb\u7597\u654f\u611f\uff1b<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u7eaf C797S \u7a81\u53d8\uff1a\u5c0f\u90e8\u5206\u60a3\u8005\u4ec5\u6709 C797S \u7a81\u53d8, \u672a\u5408\u5e76 T790M \u7a81\u53d8, \u5982\u679c C797S \u5728 T790M \u91ce\u751f\u578b\u7ec6\u80de\u4e2d\u53d1\u751f, \u5219\u4f1a\u5bfc\u81f4\u5bf9\u5965\u5e0c\u66ff\u5c3c\u8010\u836f, \u800c\u4fdd\u7559\u5bf9\u7b2c\u4e00\u4ee3 TKIs \u7684\u654f\u611f\u6027\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">T790M \u51cf\u5c11\u6216\u6d88\u5931:&nbsp;<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">T790M \u7a81\u53d8\u51cf\u5c11\u6216\u6d88\u5931\u53ef\u80fd\u662f\u5965\u5e0c\u66ff\u5c3c\u9009\u62e9\u6027\u538b\u529b\u7684\u7ed3\u679c, \u4f7f T790M \u7a81\u53d8\u9634\u6027\u514b\u9686\u6210\u4e3a\u4e3b\u5bfc, \u4e5f\u53cd\u6620\u4e86\u80bf\u7624\u7684\u5f02\u8d28\u6027\u3002T790M \u7684\u7a81\u53d8\u8d1f\u8377\u53ef\u4ee5\u9884\u6d4b\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u6548\u679c, \u7a81\u53d8\u8d1f\u8377\u8d8a\u5927, \u6548\u679c\u8d8a\u597d\u3002\u76f8\u53cd,T790M \u6d88\u5931\u7684\u60a3\u8005\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u7684\u6548\u679c\u66f4\u5dee\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"    style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: flex;justify-content: flex-start;align-items: flex-end;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 1.8em;text-align: center;height: 1.8em;line-height: 1.8em;font-size: 18px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);border-radius: 100%;overflow-wrap: break-word !important;\">0<span class=\"\"  title=\"\"  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2<\/span><\/section>\n<section style=\"margin-bottom: 0.25em;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);border-top-color: rgb(61, 170, 214);border-left-color: rgb(61, 170, 214);border-right-color: rgb(61, 170, 214);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u975e\u4f9d\u8d56 EGFR \u901a\u8def<\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">MET \u548c ERBB2 (HER2) \u6269\u589e\uff1a<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">MET \u548c HER2 \u6269\u589e\u4f5c\u4e3a\u91cd\u8981\u7684\u65c1\u8def\u6fc0\u6d3b\u9014\u5f84, \u5728\u4e00\u4ee3\u53ca\u4e09\u4ee3 TKI \u836f\u7269\u8010\u836f\u673a\u5236\u4e2d\u90fd\u5177\u6709\u91cd\u8981\u5730\u4f4d\u3002MET \u5c5e\u4e8e\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53, \u5177\u6709\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027, \u53c2\u4e0e\u7ec6\u80de\u4fe1\u606f\u4f20\u5bfc\u3001\u7ec6\u80de\u9aa8\u67b6\u91cd\u6392\u7684\u8c03\u63a7, \u662f\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u548c\u8fd0\u52a8\u7684\u91cd\u8981\u56e0\u7d20\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">MET \u6291\u5236\u5242\u514b\u5511\u66ff\u5c3c\u5355\u72ec\u6216\u8054\u5408\u5965\u897f\u66ff\u5c3c\u53ef\u4ee5\u8fc5\u901f\u6539\u5584\u643a\u5e26 MET \u6269\u589e\u7684\u5965\u897f\u66ff\u5c3c\u8010\u836f\u60a3\u8005\u7684\u75c5\u60c5\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">HER2 \u548c MET \u6269\u589e\u53ef\u4ee5\u5728\u5e94\u7528\u7b2c\u4e09\u4ee3 EGFR- TKI \u4e4b\u524d\u5c31\u5b58\u5728, \u4e5f\u53ef\u4ee5\u5728\u5e94\u7528\u7b2c\u4e09\u4ee3 EGFR-TKI \u4e4b\u540e\u51fa\u73b0, \u4f34\u6216\u4e0d\u4f34 T790M \u7a81\u53d8\u6d88\u5931\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">T-DM1 \u8054\u5408\u5965\u897f\u66ff\u5c3c\u53ef\u4ee5\u5ef6\u8fdf\u5e76\u6cbb\u7597\u5965\u897f\u66ff\u5c3c\u7684\u8010\u836f\uff08T-DM1 \u662f\u4e00\u79cd\u6297\u4f53\u2014\u836f\u7269\u5076\u8054\u7269\uff0c\u7531 HER2 \u6297\u4f53\u66f2\u59a5\u73e0\u5355\u6297\u8fde\u63a5\u5fae\u7ba1\u86cb\u767d\u6291\u5236\u5242 emtansine\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">PIK3CA \u57fa\u56e0\u7a81\u53d8\uff1a<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u901a\u8fc7 PI3K\/AKT\/mTOR \u9014\u5f84\u6fc0\u6d3b\u7684 PI3K \u8102\u8d28\u6fc0\u9176\u5bb6\u65cf\u4e9a\u57fa PIK3CA \u662f\u80ba\u817a\u764c\u7684\u81f4\u764c\u9a71\u52a8\u57fa\u56e0\u4e4b\u4e00, \u5e38\u4e0e HER2\u3001 MET \u53ca EGFR \u7b49\u5176\u4ed6\u7a81\u53d8\u5408\u5e76\u5b58\u5728, \u5b58\u5728 PIK3CA \u7a81\u53d8\u7684\u80ba\u764c\u60a3\u8005\u4e2d\u4f4d\u751f\u5b58\u65f6\u95f4\u66f4\u77ed\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50-1 \u53d7\u4f53&nbsp;<\/span><span style=\"max-width: 100%;color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">( Insulin-like growth factor-1 receptor, IGF1R ) \u901a\u8def\uff1a<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">IGF1R \u4e3b\u8981\u901a\u8fc7\u4e0b\u6e38 PI3K\/Akt \u4fe1\u53f7\u901a\u8def\u53c2\u4e0e\u8c03\u8282\u7ec6\u80de\u751f\u957f\u3001\u5206\u5316\u3001\u51cb\u4ea1\u3001\u8f6c\u5316\u548c\u5176\u4ed6\u91cd\u8981\u7684\u751f\u7406\u8fc7\u7a0b, IGF1R \u5bfc\u81f4 EGFR-TKI \u7ee7\u53d1\u8010\u836f\u4e5f\u4e3b\u8981\u662f\u901a\u8fc7 PI3K-AKT \u9014\u5f84\u5b9e\u73b0\u7684\u3002\u53ef\u901a\u8fc7\u5e94\u7528 IGF1R \u6291\u5236\u5242\u8054\u5408 EGFR- TKIs \u6cbb\u7597\u6765\u514b\u670d\u8010\u836f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"    style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;display: flex;justify-content: flex-start;align-items: flex-end;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 1.8em;text-align: center;height: 1.8em;line-height: 1.8em;font-size: 18px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);border-radius: 100%;overflow-wrap: break-word !important;\">0<span class=\"\"  title=\"\"  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3<\/span><\/section>\n<section style=\"margin-bottom: 0.25em;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);border-top-color: rgb(61, 170, 214);border-left-color: rgb(61, 170, 214);border-right-color: rgb(61, 170, 214);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7ec6\u80de\u8868\u578b\u7684\u8f6c\u53d8<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u7b2c\u4e00\u4ee3\u548c\u7b2c\u4e09\u4ee3 EGFR-TKIs \u6cbb\u7597\u540e\u90fd\u80fd\u89c2\u5bdf\u5230 NSCLC \u7684 SCLC \u8f6c\u5316, \u5176\u5728\u7b2c\u4e00\u4ee3 EGFR-TKI \u7684\u8010\u836f\u673a\u5236\u4e2d\u5360 11%\u3002Rb1 \u548c p53 \u57fa\u56e0\u5931\u6d3b\u7684 EGFR \u7a81\u53d8\u817a\u764c\u66f4\u6613\u53d1\u751f SCLC \u8f6c\u5316\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e34\u5e8a\u4e0a\u901a\u5e38\u4f7f\u7528\u94c2\u7c7b\u53cc\u8054\u5316\u7597\uff0c\u6765\u6cbb\u7597\u5c0f\u7ec6\u80de\u80ba\u764c\u8f6c\u5316\u7684\u5965\u897f\u66ff\u5c3c\u8010\u836f\u60a3\u8005\u3002\u4e0e\u5bf9\u5965\u897f\u66ff\u5c3c\u654f\u611f\u7684\u7ec6\u80de\u76f8\u6bd4\uff0c\u5c0f\u7ec6\u80de\u80ba\u764c\u8f6c\u5316\u7684\u8010\u836f\u7ec6\u80de\u5bf9\u4e8e\u7d2b\u6749\u9187\u66f4\u52a0\u654f\u611f\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\uff0c\u7d2b\u6749\u9187\u53ef\u80fd\u662f\u643a\u5e26\u5c0f\u7ec6\u80de\u80ba\u764c\u8f6c\u5316\u7684\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u60a3\u8005\u7684\u6709\u5229\u9009\u62e9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c\u4e09\u4ee3 EGFR-TKIs \u7684\u8010\u836f\u673a\u5236\u4e0e\u7b2c\u4e00\u4ee3\u7c7b\u4f3c, \u4f46\u662f\u66f4\u4e3a\u590d\u6742, \u5f80\u5f80\u591a\u79cd\u673a\u5236\u5e76\u5b58\u3002\u51fa\u73b0\u8010\u836f\u540e\u9700\u8981\u66f4\u4e3a\u51c6\u786e\u7684\u8840\u6db2\u3001\u7ec4\u7ec7\u5b66\u68c0\u6d4b, \u5bfb\u627e\u53ef\u80fd\u7684\u8010\u836f\u673a\u5236, \u4e3a\u4e34\u5e8a\u4e0b\u4e00\u6b65\u6cbb\u7597\u63d0\u4f9b\u7ebf\u7d22\u3002\u540c\u65f6\uff0c\u6362\u4e00\u79cd\u601d\u8def\uff0c\u5982\u5c1d\u8bd5\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3001\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u7b49\uff0c\u4ece\u53e6\u4e00\u79cd\u89d2\u5ea6\u53bb\u653b\u514b\u80bf\u7624\uff0c\u6216\u8bb8\u4f1a\u6536\u83b7\u4e0d\u9519\u7684\u6548\u679c\u3002\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u540e\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u9700\u8981\u7efc\u5408\u53bb\u8bc4\u4f30\u4e0e\u5236\u5b9a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n<h2 class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283901&amp;idx=2&amp;sn=4fcc6adcbf1bfb23022447ebaa946054&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3 \u4e2a\u75c5\u4f8b\u6559\u4f60\u641e\u5b9a\u764c\u75c7\u76f8\u5173\u9759\u8109\u8840\u6813\u6813\u585e<\/a><\/h2>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(84, 84, 84);letter-spacing: 0.68px;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283749&amp;idx=1&amp;sn=d2f38c86ef6387a4f76831f24a629a38&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 17px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u518d\u5582\u517b\u7efc\u5408\u5f81\uff1a<\/span><\/a><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283749&amp;idx=1&amp;sn=d2f38c86ef6387a4f76831f24a629a38&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8425\u517b\u8865\u5145\u4e0d\u80fd\u64cd\u4e4b\u8fc7\u6025<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;color: rgb(84, 84, 84);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283788&amp;idx=1&amp;sn=a386b55a7981f5ff8b16db80be6b9385&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u53c8\u6709\u65b0\u65b9\u6848<\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;color: rgb(84, 84, 84);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283728&amp;idx=1&amp;sn=cf5cb89f3b41f3affcbad8211d487ae6&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e73\u817a\u764c 21 \u57fa\u56e0\u68c0\u6d4b\u7684\u90a3\u4e9b\u4e8b<\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;color: rgb(84, 84, 84);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.7px;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 0.7px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6295\u7a3f\uff1adecie@qq.com<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9898\u56fe\uff1a\u7ad9\u9177\u6d77\u6d1b<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 640px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558315084.gif\" alt=\"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565\" title=\"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558315084.png\" alt=\"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565\" title=\"\u4e00\u6587\u638c\u63e1 | EGFR-TKI \u8010\u836f\u7a81\u53d8\u673a\u5236\u53ca\u5bf9\u5e94\u7b56\u7565\"  \/><\/p>\n<section label=\"Copyright \u00a9 2015 playhudong All Rights Reserved.\" style=\"border-width: initial;border-color: initial;border-style: none;margin: 1em auto;color: rgb(0, 0, 0);\" donone=\"shifuMouseDownStyle(&#39;shifu_c_037&#39;)\">\n<section class=\"xhr wihudong\" style=\"height: 10em;font-size: 1em;line-height: 1.5em;overflow: auto;margin-right: auto;margin-left: auto;padding: 1em;background: rgb(240, 240, 240);\">\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><br  \/><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">1. Soria JC, Ohe Y, Vansteenkiste J, et al. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer. N Engl J Med, 2018, 378(2): 113-125. doi:10.1056\/NEJMoa1713137\uff1b<\/span><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">2. Thress KS, Paweletz CP, Felip E, et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat Med, 2015, 21(6): 560-562. doi:&nbsp;10.1038\/nm.3854\uff1b<\/span><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">3. Ortiz-Cuaran S, Scheffler M, Plenker D, et al. Heterogeneous mechanisms of primary and acquired resistance to third generation EGFR inhibitors. Clin Cancer Res, 2016, 22(19): 4837-4847\uff1b<\/span><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">4. Chaft JE, Arcila ME, Paik PK, et al. Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling. Mol Cancer Ther, 2012, 11: 485-491\uff1b<\/span><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">5. Park JH, Choi YJ, Kim SY, et al. Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer. Oncotarget, 2016, 7(16): 22005- 22015. doi:10.18632\/oncotarget.8013\uff1b<\/span><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">6. Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med, 2011, 3(75): 75ra26. doi:10.1126\/scitranslmed.3002003\uff1b<\/span><\/p>\n<p style=\"white-space: normal;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);\"><span style=\"font-size: 14px;color: rgb(127, 127, 127);\">7. Engelman JA , Zejnullahu K , Mitsudomi T , et al. MET am- plification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling[J]. Science , 316(5827) : 1039- 1043\uff1b<\/span><\/p>\n<p style=\"color: rgb(51, 51, 51);white-space: normal;min-height: 1em;line-height: 1.5;\"><span style=\"color: rgb(127, 127, 127);font-size: 14px;caret-color: red;\">8. Yu Q , Jiang D , Li Y. Current status and prospect of T790M mutation in non-small cell lung cancer [J]. Zhong- guo Fei Ai Za Zhi , 2017 , 20(3) : 199-204.<\/span><\/p>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80ba\u764c\u662f\u5168\u7403\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u4e2d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7ea6\u5360 85%\uff0c\u5927\u90e8\u5206 NSCLC \u60a3\u8005\u5728 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":111000,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/110999"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=110999"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/110999\/revisions"}],"predecessor-version":[{"id":111004,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/110999\/revisions\/111004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/111000"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=110999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=110999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=110999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}