{"id":111230,"date":"2019-05-18T00:00:50","date_gmt":"2019-05-20T01:20:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/111230\/"},"modified":"2019-05-20T09:20:21","modified_gmt":"2019-05-20T01:20:21","slug":"4c2ceb355d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/111230\/","title":{"rendered":"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011 \u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684I\u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
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\u70b9\u51fb\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/span>\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong>\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n

\u516c\u4f17\u53f7\uff1ashiyan589<\/span><\/p>\n

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SPH1188-11    <\/span>
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1.\u8bc4\u4ef7SPH1188-11\u7247\u5728\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3002 <\/p>\n


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2.\u8bc4\u4ef7SPH1188-11\u7247\u5728\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3002 <\/p>\n


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3.\u521d\u6b65\u63a2\u7d22SPH1188-11\u7247\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6709\u6548\u6027\uff0c\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u3002<\/p>\n


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1. \u5e74\u9f8418-70\u5468\u5c81\uff0c\u7537\u5973\u5747\u53ef\uff1b<\/p>\n

2. \u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u4e34\u5e8a\u5206\u671f\u4e3a\u2162B\u6216\u2163\u671f\uff0c\u66fe\u63a5\u53d7\u8fc7\u7b2c\u4e00\u4ee3EGFR-TKI\u548c\/\u6216\u5316\u7597\u5931\u8d25\u6216\u4e0d\u80fd\u8010\u53d7\uff08\u7b2c\u4e00\u4ee3EGFR-TKI\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\u7b49\uff09\uff1b\u65e0\u8bbaEGFR\u72b6\u6001\uff0c\u4e14\u4e0d\u80fd\u63a5\u53d7\u6839\u6cbb\u624b\u672f\u6216\u653e\u7597\uff1b<\/span><\/p>\n

3. \u6309\u7167\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff0cResponse Evaluation Criteria In Solid Tumors\uff09\u7248\u672c1.1\uff0c\u60a3\u8005\u81f3\u5c11\u5177\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\uff1b<\/span><\/p>\n

4. \u9884\u671f\u751f\u5b583\u4e2a\u6708\u4ee5\u4e0a\uff1b<\/span><\/p>\n

5. ECOG-PS\u8bc4\u5206\u4e3a0-1\u5206\uff1b<\/span><\/p>\n

6. \u80b2\u9f84\u5973\u6027\u5fc5\u987b\u5728\u8bd5\u9a8c\u7528\u836f\u5f00\u59cb\u524d7\u5929\u5185\u884c\u598a\u5a20\u8bd5\u9a8c\u4e14\u7ed3\u679c\u4e3a\u9634\u6027\uff0c\u5e76\u5728\u8bd5\u9a8c\u671f\u95f4\u540c\u610f\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u76f4\u81f3\u7814\u7a76\u836f\u7269\u7ec8\u6b62\u540e3\u4e2a\u6708\u3002\u7537\u6027\u5fc5\u987b\u540c\u610f\u5728\u7814\u7a76\u671f\u95f4\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\u76f4\u81f3\u7814\u7a76\u836f\u7269\u7ec8\u6b62\u540e3\u4e2a\u6708\uff1b<\/span><\/p>\n

7. \u7406\u89e3\u5e76\u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u3002     <\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011 <\/p>\n

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1. \u5728\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d7\u5929\u5185\u62165\u4e2a\u534a\u8870\u671f\uff08\u53d6\u5176\u957f\u8005\uff09\u5185\u4f7f\u7528EGFR-TKI\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\u7b49\uff09\uff1b<\/p>\n

2. \u65e2\u5f80\u4f7f\u7528\u8fc72\u4ee3\u62163\u4ee3EGFR-TKI\u7684\u53d7\u8bd5\u8005\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u963f\u6cd5\u66ff\u5c3c\u3001\u5965\u5e0c\u66ff\u5c3c\u7b49\uff09\u2018<\/span><\/p>\n

3. <\/span>\u5728\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d4\u5468\u5185\u4f7f\u7528\u8fc7\u7ec6\u80de\u6bd2\u5316\u7597\u6216\u5176\u4ed6\u6297\u80bf\u7624\u836f\u7269\uff1b<\/span><\/p>\n

4. \u5728\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d4\u5468\u5185\u8fdb\u884c\u8fc7\u5927\u624b\u672f\uff08\u9664\u5916\u8840\u7ba1\u652f\u67b6\u690d\u5165\u672f\uff09\uff1b<\/span><\/p>\n

5. \u5728\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d4\u5468\u5185\u63a5\u53d7\u653e\u7597\uff1b<\/span><\/p>\n

6. \u5728\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d7\u5929\u5185\u4f7f\u7528CYP3A4\u7684\u5f3a\u6291\u5236\u5242\u548c\/\u6216\u5f3a\u8bf1\u5bfc\u5242\u548c\/\u6216CYP2D6\u5f3a\u6291\u5236\u5242\u3002\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u540e\u65e0\u6cd5\u505c\u7528CYP3A4\u7684\u5f3a\u6291\u5236\u5242\u548c\/\u6216\u5f3a\u8bf1\u5bfc\u5242\u548c\/\u6216CYP2D6\u5f3a\u6291\u5236\u5242\uff1b<\/span><\/p>\n

7. \u5728\u8bd5\u9a8c\u7528\u836f\u5f00\u59cb\u524d7\u5929\u5185\uff0c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\uff1a -\u8840\u5e38\u89c4\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u6570\uff1c1.5\u00d7109\/L\uff0c\u8840\u5c0f\u677f\uff1c100\u00d7109\/L\uff0c\u8840\u7ea2\u86cb\u767d\uff1c90g\/L\uff1b -\u809d\u529f\u80fd\uff1a\u603b\u80c6\u7ea2\u7d20\uff1e1.5\u00d7ULN\uff08\u809d\u8f6c\u79fb\u6216Gilbert\u2019s\u7efc\u5408\u5f81\u65f6\u603b\u80c6\u7ea2\u7d20\uff1e3\u00d7ULN\uff09\uff0cALT\uff1e2.5\u00d7ULN\uff0cAST\uff1e2.5\u00d7ULN \uff08\u809d\u8f6c\u79fb\u65f6ALT\u6216\/\u548cAST\uff1e5\u00d7ULN\uff09\uff1b -\u80be\u529f\u80fd\uff1a\u8840\u808c\u9150\uff1e1.5\u00d7ULN\u4e14\u808c\u9150\u6e05\u9664\u7387\uff1c50ml\/min\uff0c\u4ec5\u5728\u8840\u808c\u9150\uff1e1.5\u00d7ULN\u65f6\u8ba1\u7b97\u808c\u9150\u6e05\u9664\u7387\uff0c\u91c7\u7528Cockcroft Gault\u516c\u5f0f\u8ba1\u7b97\u808c\u9150\u6e05\u9664\u7387\uff1b<\/span><\/p>\n

8. \u6839\u636e\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u8bc4\u4ef7\u6807\u51c6\uff08NCI-CTCAE 4.03\uff09\u67092\u7ea7\u53ca2\u7ea7\u4ee5\u4e0a\u6162\u6027\u6bd2\u6027\u53cd\u5e94\uff08\u4e0d\u5305\u62ec\u8131\u53d1\u3001\u65e2\u5f80\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u5bfc\u81f4\u7684\u795e\u7ecf\u6bd2\u6027\uff09\u672a\u75ca\u6108\u8005\uff1b<\/span><\/p>\n

9. \u810a\u9ad3\u538b\u8feb\u6216\u8111\u8f6c\u79fb\uff0c\u9664\u5916\u65e0\u75c7\u72b6\u7684\u60a3\u8005\u6216\u7a33\u5b9a\u76844\u5468\u5185\u65e0\u987b\u4f7f\u7528\u6fc0\u7d20\u6cbb\u7597\u7684\u60a3\u8005\uff1b<\/span><\/p>\n

10. \u6839\u636e\u7814\u7a76\u8005\u5224\u65ad\uff0c\u5b58\u5728\u4e25\u91cd\u6216\u4e0d\u80fd\u63a7\u5236\u7684\u5168\u8eab\u6027\u75be\u75c5\uff08\u5982\u4e0d\u7a33\u5b9a\u6216\u4e0d\u80fd\u4ee3\u507f\u7684\u547c\u5438\u3001\u5fc3\u810f\u3001\u809d\u810f\u3001\u80be\u810f\u6216\u4ee3\u8c22\u6027\u75be\u75c5\uff09\u7684\u8bc1\u636e\u3002\u6d3b\u52a8\u6027\u51fa\u8840\u6027\u75be\u75c5\u3001\u6d3b\u52a8\u6027\u611f\u67d3\u6027\u75be\u75c5\u5305\u62ec\u4e59\u809d\u8868\u9762\u6297\u539f\u9633\u6027\u4e14HBV-DNA\u68c0\u6d4b\uff1e\u68c0\u6d4b\u4e0b\u9650\uff0c\u6216\u4e19\u809d\u6297\u4f53\u9633\u6027\uff0c\u6216HIV\u6297\u4f53\u9633\u6027\uff1b<\/span><\/p>\n

11. \u5fc3\u810f\u6807\u51c6\uff1aQTc\uff1e480msec\u3002\u5b58\u5728\u53ef\u5bfc\u81f4QTc\u5ef6\u957f\u6216\u5fc3\u5f8b\u5931\u5e38\u7684\u56e0\u7d20\u5982\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u4f4e\u94be\u8840\u75c7\u3001\u5148\u5929\u6027\u957fQT\u7efc\u5408\u5f81\uff0c\u957fQT\u7efc\u5408\u5f81\u7684\u5bb6\u65cf\u53f2\uff0c\u5176\u4ed6\u5df2\u77e5\u53ef\u5ef6\u957fQT\u95f4\u671f\u7684\u5408\u5e76\u7528\u836f\u3002\u5b58\u5728\u4efb\u4f55\u4e0d\u7a33\u5b9a\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u7ebd\u7ea6\u5fc3\u810f\u75c5\u5b66\u4f1aNYHA\u5fc3\u529f\u80fd\u5206\u7ea7\u8fbe\u2162\u6216\u2163\u7ea7\u3001\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u4e0d\u7a33\u5b9a\u6027\u5fc3\u7ede\u75db\u3001\u4e00\u5e74\u5185\u5fc3\u808c\u6897\u585e\u75c5\u53f2\u3001\u56db\u7ea7\u9ad8\u8840\u538b\uff09\u3002LVEF\uff1c50%\uff1b<\/span><\/p>\n

12. \u65e2\u5f80\u60a3\u95f4\u8d28\u6027\u80ba\u75c5\u3001\u836f\u7269\u8bf1\u5bfc\u7684\u95f4\u8d28\u6027\u75be\u75c5\u3001\u9700\u8981\u6fc0\u7d20\u6cbb\u7597\u7684\u653e\u5c04\u6027\u80ba\u708e\u6216\u4efb\u4f55\u5177\u4e34\u5e8a\u8bc1\u636e\u7684\u6d3b\u52a8\u6027\u95f4\u8d28\u6027\u80ba\u75c5\uff1b<\/span><\/p>\n

13. \u5b58\u5728\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\uff1b<\/span><\/p>\n

14. \u6709\u663e\u8457\u7684\u80c3\u80a0\u9053\u5f02\u5e38\uff0c\u4ee5\u8179\u6cfb\u4e3a\u7279\u5f81\uff1b<\/span><\/p>\n

15. \u5b58\u5728\u541e\u54bd\u56f0\u96be\u6216\u5f71\u54cd\u836f\u7269\u5438\u6536\u7684\u6d88\u5316\u9053\u75be\u75c5\u6216\u5b58\u5728\u5176\u5b83\u4e0d\u80fd\u53e3\u670d\u836f\u7269\u7684\u969c\u788d\u6216\u75be\u60a3\uff1b<\/span><\/p>\n

16. \u4e00\u5e74\u5185\u6709\u89d2\u819c\u708e\u3001\u6e83\u75a1\u6027\u89d2\u819c\u708e\u3001\u4e25\u91cd\u5e72\u773c\u75c7\u7b49\u663e\u8457\u7684\u773c\u79d1\u75be\u75c5\u53f2\uff1b<\/span><\/p>\n

17. \u5728\u4e94\u5e74\u5185\u60a3\u6709\u4efb\u4f55\u5176\u5b83\u6076\u6027\u80bf\u7624\uff08\u5b8c\u5168\u6cbb\u6108\u7684\u5bab\u9888\u539f\u4f4d\u764c\u6216\u57fa\u5e95\u7ec6\u80de\u6216\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\u76ae\u80a4\u764c\u9664\u5916\uff09\uff1b<\/span><\/p>\n

18. \u65e2\u5f80\u6709\u660e\u786e\u7684\u795e\u7ecf\u6216\u7cbe\u795e\u969c\u788d\u53f2\uff0c\u5305\u62ec\u766b\u75eb\u6216\u75f4\u5446\uff1b<\/span><\/p>\n

19. \u5df2\u77e5\u5bf9\u8bd5\u9a8c\u836f\u7269\u6216\u8be5\u4ea7\u54c1\u7684\u4efb\u4e00\u8d4b\u5f62\u5242\u8fc7\u654f\uff1b<\/span><\/p>\n

20. \u5728\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d4\u5468\u5185\u53c2\u52a0\u5176\u4ed6\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\uff1b<\/span><\/p>\n

21. \u540c\u65f6\u63a5\u53d7\u5176\u4ed6\u4efb\u4f55\u6297\u80bf\u7624\u6cbb\u7597\uff1b<\/span><\/p>\n

22. \u598a\u5a20\u6216\u54fa\u4e73\u671f\u5987\u5973\uff1b<\/span><\/p>\n

23. \u7814\u7a76\u8005\u8ba4\u4e3a\u4e0d\u9002\u5b9c\u53c2\u52a0\u672c\u7814\u7a76\u7684\u5176\u4ed6\u60c5\u51b5\u3002  <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u540d\u65b9\u5f0f<\/span><\/section>\n

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\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\uff0c\u56de\u590d\u201c\u5165\u7ec4\u201d\u5373\u53ef<\/strong><\/span><\/span><\/p>\n

\u2193<\/strong>\u2193<\/strong>\u2193<\/strong>\u2193<\/strong><\/strong><\/span><\/span><\/p>\n

\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011<\/p>\n


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\"\u3010\u80ba\u764c-\u60a3\u8005\u62db\u52df\u3011\u70b9\u51fb\u201c<\/span>\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u60c5<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u9a6c\u4e0a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c \u516c\u4f17\u53f7\uff1ashiyan589 \u6297\u764c\u6307\u5357\u70b9\u51fb\u4e0b\u65b9 \u2193\u2193\u2193 \u5165\u7ec4\u62a5\u540d\u65b9\u5f0f\u89c1\u6587\u672b \u2193\u2193\u2193\u2193 \u8bd5\u9a8c […]<\/p>\n","protected":false},"author":1,"featured_media":111231,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111230"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=111230"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111230\/revisions"}],"predecessor-version":[{"id":111248,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111230\/revisions\/111248"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/111231"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=111230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=111230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=111230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}