{"id":111311,"date":"2019-05-18T00:00:50","date_gmt":"2019-05-20T01:20:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/111311\/"},"modified":"2019-05-20T09:20:49","modified_gmt":"2019-05-20T01:20:49","slug":"37322e0156","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/111311\/","title":{"rendered":"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5421\u54af\u66ff\u5c3c\u662f\u6052\u745e\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670d<\/span><h-char class=\"\" unicode=\"3001\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u3001<\/span><\/h-inner><\/h-char><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0d\u53ef\u9006<\/span><h-char class=\"\" unicode=\"3001\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u3001<\/span><\/h-inner><\/h-char><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6cdb-ErbB\u53d7\u4f53\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/span><h-char class=\"\" unicode=\"ff08\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff08<\/span><\/h-inner><\/h-char><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">TKI<\/span><h-char class=\"\" unicode=\"ff09\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff09<\/span><\/h-inner><\/h-char><h-char class=\"\" unicode=\"ff0c\" prev=\"bd-close bd-end\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c<\/span><\/h-inner><\/h-char><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u540c\u65f6\u5177\u6709\u6297EGFR\/HER1<\/span><h-char class=\"\" unicode=\"3001\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u3001<\/span><\/h-inner><\/h-char><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">HER2 \u4ee5\u53caHER4\u6d3b\u6027<\/span><h-char class=\"\" unicode=\"ff0c\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><h-inner style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c<\/span><\/h-inner><\/h-char><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e5f\u88ab\u79f0\u4f5c\u53e3\u670d\u8d6b\u8d5b\u6c40\uff0c\u662f\u6052\u745e\u5bc4\u4e88\u539a\u671b\u7684\u4e00\u4e2a\u65b0\u836f\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 2em;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2018\u5e748\u670813\u65e5\uff0c<span style=\"font-size: 14px;letter-spacing: 2px;\">\u5421\u54af\u66ff\u5c3c<\/span>\u51ed\u501fII\u671f\u4e34\u5e8a\u7684\u6570\u636e\u88abNMPA\u6709\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\u3002<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u8be5II\u671f\u7814\u7a76\u5165\u7ec4\u4e86128\u4f8b\u7ecf\u84bd\u73af\u7c7b\u548c\u7d2b\u6749\u7c7b\u836f\u7269\u6cbb\u7597\u5931\u8d25\u4e14\u590d\u53d1\/\u8f6c\u79fb\u540e\u5316\u7597\u4e0d\u8d85\u8fc7 2 \u7ebf\u7684Her2+\u4e73\u817a\u764c\u60a3\u8005\uff0c\u6bd4\u8f83\u5421\u54af\u66ff\u5c3c+\u5361\u57f9\u4ed6\u6ee8\u4e0e\u62c9\u5e15\u66ff\u5c3c+\u5361\u57f9\u4ed6\u6ee8\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 2em;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ed3\u679c\u663e\u793a\uff0c\u5421\u54af\u66ff\u5c3c+\u5361\u57f9\u4ed6\u6ee8\u7ec4\u76f8\u6bd4\u62c9\u5e15\u66ff\u5c3c+\u5361\u57f9\u4ed6\u6ee8\u7ec4ORR\u663e\u8457\u63d0\u9ad8\uff0878.5% vs 57.1%\uff09\uff0cPFS\u663e\u8457\u5ef6\u957f\uff0818.1 vs 7.0\u4e2a\u6708\uff09\uff0c\u75be\u75c5\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e63.7%\u3002\u5421\u54af\u66ff\u5c3c\u7684\u8010\u53d7\u6027\u4e5f\u597d\u4e8e\u62c9\u5e15\u66ff\u5c3c\u3002<\/span><\/p>\n<p style=\"line-height: 2em;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u5728ASCO2019\u5927\u4f1a\u7684\u4f1a\u8bae\u6458\u8981\u4e2d\uff0c\u6052\u745e\u516c\u5e03\u4e86\u5421\u54af\u66ff\u5c3c\u4e8c\u7ebf\u6cbb\u7597Her2+\u4e73\u817a\u764c\u60a3\u8005\u7684III\u671f\u6570\u636e\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 2em;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558315248.jpg\" alt=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\" title=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6052\u745e\u6b64\u6b21\u5728ASCO\u4e0a\u516c\u5e03\u7684III\u671f\u7814\u7a76\u6570\u636e\u662f\u57fa\u4e8e<span style=\"font-size: 14px;letter-spacing: 2px;\">2016\u5e747\u6708-2017\u5e7411\u6708<\/span>\u5728\u4e2d\u56fd\u7eb3\u5165\u7684279\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d2b\u6749\u70f7\u548c\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684HER2+\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u5206\u6790\u7ed3\u679c\u3002\u60a3\u8005\u6309\u71672:1\u968f\u673a\u5206\u7ec4\uff0c\u5206\u522b\u7ed9\u4e88\u6bcf\u65e51\u6b21\u5421\u54af\u66ff\u5c3c400mg\u6216\u5b89\u6170\u5242\uff0821\u59291\u4e2a\u5468\u671f\uff09\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\uff081000mg\/m2\u6bcf\u65e52\u6b21\uff0c\u7b2c1-14\u5929\uff09\uff0c\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662fPFS\u3002\u5b89\u6170\u5242+\u5361\u57f9\u4ed6\u6ee8\u7ec4\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u5219\u63a5\u53d7\u5421\u54af\u66ff\u5c3c\u7684\u5355\u836f\u540e\u7eed\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ed3\u679c\u663e\u793a\uff0c\u5421\u54af\u66ff\u5c3c+\u5361\u57f9\u4ed6\u6ee8\u7ec4\u60a3\u8005\uff08n=185\uff09\u7684PFS\u76f8\u6bd4\u5b89\u6170\u5242+\u5361\u57f9\u4ed6\u6ee8\u7ec4\uff08n=94\uff09\u663e\u8457\u5ef6\u957f\uff0811.1 vs 4.1\u4e2a\u6708\uff09\uff0cORR\u663e\u8457\u63d0\u9ad8\uff0868.6% vs 16.0%\uff09\u3002\u5b89\u6170\u5242+\u5361\u57f9\u4ed6\u6ee8\u7ec4\u670971\u4f8b\u60a3\u8005\u5728\u75be\u75c5\u8fdb\u5c55\u540e\u6539\u7528\u5421\u54af\u66ff\u5c3c\u5355\u836f\u7ee7\u7eed\u6cbb\u7597\uff0c\u8fd971\u4f8b\u60a3\u8005\u91c7\u7528\u5421\u54af\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u7684ORR\u4e3a38.0%\uff0c\u4e2d\u4f4dPFS\u4e3a5.5\u4e2a\u6708\u3002\u7814\u7a76\u4e2d\u6700\u5e38\u89c1\uff08\u22655%\uff09\u76843\u7ea7\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8179\u6cfb\uff0830.8% vs 12.8%\uff09\u3001\u624b\u8db3\u7efc\u5408\u5f81\uff0815.7% vs 5.3%\uff09\u3002<\/span><\/p>\n<p style=\"line-height: 2em;\"><span style=\"max-width: 100%;letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p><img class=\"rich_pages\"      style=\"text-align: center;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558315248.png\" alt=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\" title=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\"  \/><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558315249.jpeg\" alt=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\" title=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\"  \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6765\u6e90\uff1a<\/span><a class=\"weapp_text_link\"    href=\"\"   style=\"text-decoration: underline;font-size: 14px;letter-spacing: 2px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">NextPharma<\/span><\/a><span style=\"font-size: 14px;letter-spacing: 2px;\"><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 2em;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u672c\u6b21ASCO\u5927\u4f1a\u6458\u8981\u4e2d\u540c\u65f6\u4e5f\u516c\u5e03\u4e86\u53e6\u5916\u4e24\u6b3e\u5df2\u4e0a\u5e02\u5c0f\u5206\u5b50Her2\u9776\u5411\u4e73\u817a\u764c\u836f\u7269\u7684\u5934\u5bf9\u5934\u6bd4\u8f83\u7ed3\u679c\u3002\u5728\u4ee3\u53f7\u4e3aNALA\u7684III\u671f\u3001\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u4e2d\uff0c621\u4f8b\u5df2\u7ecf\u63a5\u53d7\u8fc72\u79cd\u4ee5\u4e0aHER2\u9776\u5411\u836f\u7269\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u6309\u71671:1\u968f\u673a\u5206\u7ec4\uff0c\u5206\u522b\u7ed9\u4e88neratinib\uff08240mg\uff0c\u6bcf\u65e51\u6b21\uff09+\u5361\u57f9\u4ed6\u6ee8\uff08750mg\/m2\uff0c\u6bcf\u65e52\u6b21\uff09\u6216lapatinib\uff081250mg\uff0c\u6bcf\u65e51\u6b21\uff09+\u5361\u57f9\u4ed6\u6ee8\uff081000mg\/m2\uff0c\u6bcf\u65e52\u6b21\uff09\u3002<\/span><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 2em;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7ed3\u679c\u663e\u793a\uff0cneratinib+\u5361\u57f9\u4ed6\u6ee8\u548clapatinib+\u5361\u57f9\u4ed6\u6ee8\u76846\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u5206\u522b\u4e3a47.2%\u548c37.8%\uff0c12\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u5206\u522b\u4e3a28.8%\u548c14.8%\u30026\u4e2a\u6708\u603b\u751f\u5b58\u7387\u5206\u522b\u4e3a90.2%\u548c 87.5%\uff0c12\u4e2a\u6708\u603b\u751f\u5b58\u7387\u5206\u522b\u4e3a72.5%\u548c66.7%\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u4e24\u7ec4\u6cbb\u7597\u76f8\u5173\u7684\u7d27\u6025\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u76f8\u4f3c\uff0cneratinib+\u5361\u57f9\u4ed6\u6ee8\u7ec4\u76843\u7ea7\u4ee5\u4e0a\u8179\u6cfb\u53d1\u751f\u7387\u9ad8\u4e8e\u540e\u8005\uff0824.4% vs 12.5%\uff09\uff0c\u56e0\u4e3a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u800c\u7ec8\u6b62\u6cbb\u7597\u7684\u60a3\u8005\u6bd4\u4f8b\u4f4e\u4e8e\u540e\u8005\uff0810.9% vs 14.5%\uff09\u3002<\/span><\/p>\n<p style=\"line-height: 2em;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558315249.jpeg\" alt=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\" title=\"\u5421\u54af\u66ff\u5c3c\u4e73\u817a\u764cIII\u671f\u6570\u636e\u516c\u5e03\uff1aPFS\u5ef6\u957f7\u4e2a\u6708\uff0c\u5ba2\u89c2\u5e94\u7b54\u738768.6%\"  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5421\u54af\u66ff\u5c3c\u662f\u6052\u745e\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u3001\u4e0d\u53ef\u9006\u3001\u6cdb-ErbB\u53d7\u4f53\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u540c\u65f6\u5177\u6709\u6297EGFR\/HER 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