{"id":111806,"date":"2019-05-17T00:00:50","date_gmt":"2019-05-20T01:26:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/111806\/"},"modified":"2019-05-20T09:26:53","modified_gmt":"2019-05-20T01:26:53","slug":"b14c7cb04a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/111806\/","title":{"rendered":"\u901f\u9012 | \u9776\u5411\u6cbb\u7597\u80c6\u7ba1\u764c\uff0c\u53e3\u670dIDH\u6291\u5236\u52423\u671f\u4e34\u5e8a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9"},"content":{"rendered":"
\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u8fd1\u65e5\uff0c\u5408\u4f5c\u4f19\u4f34Agios Pharmaceuticals\u516c\u53f8\u516c\u5e03\uff0c\u5176\u6297\u764c\u836f\u7269Tibsovo\uff08ivosidenib\uff09\u7684\u4e00\u9879\u5168\u7403\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002\u643a\u5e26\u6613\u611f\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\uff08IDH1<\/em>\uff09\u57fa\u56e0\u7a81\u53d8\u7684\u80c6\u7ba1\u764c\u60a3\u8005\u7ecf\u5316\u7597\u540e\u91c7\u7528Tibosovo\u6cbb\u7597\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u76f8\u6bd4\u5b89\u6170\u5242\u7ec4\u6709\u663e\u8457\u6539\u5584<\/strong>\u3002\u5b89\u5168\u6027\u4e0e\u8fc7\u53bb\u5df2\u53d1\u8868\u6570\u636e\u4fdd\u6301\u4e00\u81f4\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u901f\u9012<\/p>\n


<\/p>\n

\u80c6\u7ba1\u764c\u662f\u4e00\u79cd\u8f83\u5c11\u89c1\u7684\u6076\u6027\u80bf\u7624\uff0c\u6839\u636e\u53d1\u751f\u90e8\u4f4d\u53ef\u5206\u4e3a\u809d\u5185\u80c6\u7ba1\u764c\u548c\u809d\u5916\u80c6\u7ba1\u764c\u3002\u73b0\u6709\u7684\u5c40\u90e8\u6cbb\u7597\u9009\u62e9\u5305\u62ec\u624b\u672f\u3001\u653e\u7597\u53ca\u5176\u4ed6\u6d88\u878d\u7597\u6cd5\uff0c\u5c1a\u65e0\u6279\u51c6\u7684\u5168\u8eab\u6cbb\u7597\u624b\u6bb5\u3002\u5bf9\u4e8e\u8fdb\u5c55\u671f\u80c6\u7ba1\u764c\u6765\u8bf4\uff0c\u5316\u7597\u9009\u62e9\u6709\u9650\uff0c\u5206\u5b50\u9776\u5411\u6cbb\u7597\u4ee4\u4eba\u671f\u5f85\u3002<\/span><\/p>\n


<\/p>\n

Tibsovo\u9776\u5411\u7a81\u53d8\u7684IDH1<\/em>\u3002IDH1\u548cIDH2\u662f\u4ee3\u8c22\u9176\uff0c \u6b63\u5e38\u60c5\u51b5\u4e0b\u5e2e\u52a9\u5206\u89e3\u8425\u517b\u7269\u8d28\uff0c\u4e3a\u7ec6\u80de\u4ea7\u751f\u80fd\u91cf\u3002\u5f53\u53d1\u751f\u7a81\u53d8\u65f6\uff0cIDH\u5bfc\u81f4\u4ee3\u8c22\u4ea7\u7269d-2-\u7f9f\u57fa\u620a\u4e8c\u9178\uff082-HG\uff09\u6c34\u5e73\u5347\u9ad8\uff0c\u963b\u65ad\u7ec6\u80de\u6b63\u5e38\u5206\u5316\uff0c\u4fc3\u8fdb\u7ec6\u80de\u8fc5\u901f\u589e\u6b96\u3002IDH<\/em>\u7a81\u53d8\u5e38\u89c1\u4e8e\u5305\u62ec\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u3001\u80c6\u7ba1\u764c\u5728\u5185\u7684\u591a\u79cd\u8840\u6db2\u764c\u548c\u5b9e\u4f53\u7624\u3002\u809d\u5185\u80c6\u7ba1\u764c\u7684\u75c5\u4f8b\u4e2d\u6709\u8fd11\/5\u60a3\u8005\u643a\u5e26IDH1<\/em>\u57fa\u56e0\u7a81\u53d8\u3002<\/strong><\/span><\/p>\n


<\/span><\/p>\n

\"\u901f\u9012<\/span><\/p>\n


<\/p>\n

\u540d\u4e3aClarIDHy\u7684\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u62db\u52df\u4e86\u65e2\u5f80\u63a5\u53d7\u8fc71~2\u6b21\u6cbb\u7597\u3001\u5904\u4e8e\u665a\u671f\u5e76\u7ecf\u68c0\u6d4b\u643a\u5e26IDH1<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u80c6\u7ba1\u764c\u60a3\u8005\u3002\u622a\u81f32019\u5e741\u670831\u65e5\uff0c\u5171185\u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u7ec4\u63a5\u53d7\u53e3\u670dTibsovo\u6216\u5b89\u6170\u5242\u6cbb\u7597\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u7531\u72ec\u7acb\u7684\u653e\u5c04\u5b66\u5ba1\u67e5\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3001\u603b\u7f13\u89e3\u7387\u3001\u603b\u751f\u5b58\u7387\u3001\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u3001\u836f\u4ee3\u52a8\u529b\u5b66\/\u836f\u6548\u5b66\u3001\u751f\u6d3b\u8d28\u91cf\u8bc4\u4f30\u7b49\u3002<\/span><\/p>\n


<\/p>\n

Agios\u9884\u671f\u4e8e\u4eca\u5e749\u6708\u5e95\u5728\u6b27\u6d32\u80bf\u7624\u5b66\u4f1a\u5927\u4f1a\u4e0a\u63d0\u4ea4\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b8c\u6574\u5206\u6790\uff0c\u5e76\u8ba1\u5212\u5728\u5e74\u5e95\u4e4b\u524d\u4e3aTibsovo\u6cbb\u7597\u80c6\u7ba1\u764c\u63d0\u4ea4\u8865\u5145\u65b0\u836f\u7533\u8bf7<\/strong>\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u524dTibsovo\u5df2\u83b7<\/span>FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u643a\u5e26IDH1\u7a81\u53d8\u4e14\u4e0d\u9002\u7528\u5316\u7597\u6216\u590d\u53d1\/\u96be\u6cbb\u6027AML\u60a3\u8005<\/span><\/a>\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u5371\u53ca\u751f\u547d\u7684\u665a\u671f\u80c6\u7ba1\u764c\u8fd8\u6ca1\u6709\u83b7\u6279\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u5bf9\u4e8e\u8fd9\u79cd\u5177\u6709\u6311\u6218\u6027\u7684\u75be\u75c5\uff0cClarIDHy\u8bd5\u9a8c\u7684\u6570\u636e\u8868\u660e\uff0c\u643a\u5e26IDH1<\/em>\u7a81\u53d8\u7684\u60a3\u8005\u53ef\u4ee5\u4eceTibsovo\u5f97\u5230\u663e\u8457\u7684\u4e34\u5e8a\u76ca\u5904\uff0c\u201dAgios\u9996\u5e2d\u533b\u7597\u5b98Chris Bowden\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u4f1a\u4e0e\u76d1\u7ba1\u673a\u6784\u901a\u529b\u5408\u4f5c\uff0c\u5c3d\u5feb\u5c06\u8fd9\u4e00\u6f5c\u5728\u7597\u6cd5\u5e26\u7ed9\u60a3\u8005\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\u8d44\u6599<\/span><\/p>\n

[1] Agios Announces the Randomized Phase 3 ClarIDHy Trial of TIBSOVO\u00ae (ivosidenib) Achieved its Primary Endpoint in Previously Treated IDH1 Mutant Cholangiocarcinoma Patients. Retrieved May 16, from http:\/\/investor.agios.com\/news-releases\/news-release-details\/agios-announces-randomized-phase-3-claridhy-trial-tibsovor<\/span><\/p>\n

[2] About IDH Mutations in Cancer. Retrieved May 16, from https:\/\/www.agios.com\/patients-caregivers\/idh-mutations\/<\/span><\/p>\n


<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n

\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


<\/p>\n

\"\u901f\u9012<\/p>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u8fd1\u65e5\uff0c\u5408\u4f5c\u4f19\u4f34Agios Pharmaceuticals\u516c\u53f8\u516c\u5e03\uff0c\u5176\u6297\u764c\u836f\u7269Tibsovo\uff08 […]<\/p>\n","protected":false},"author":1,"featured_media":111807,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111806"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=111806"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111806\/revisions"}],"predecessor-version":[{"id":111811,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111806\/revisions\/111811"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/111807"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=111806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=111806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=111806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}