{"id":111824,"date":"2019-05-17T00:00:50","date_gmt":"2019-05-20T01:26:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/111824\/"},"modified":"2019-05-20T09:27:00","modified_gmt":"2019-05-20T01:27:00","slug":"b30ec43b1d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/111824\/","title":{"rendered":"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1  style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Cediranib\u662f\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3eVEGF\u53d7\u4f53\u6291\u5236\u5242\uff0c\u7136\u800c\u8fd1\u65e5\u8036\u9c81\u5927\u5b66\uff08Yale University\uff09\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u3002\u8fd9\u6b3e\u5728\u7814\u6297\u764c\u836f\u8fd8\u6709\u53e6\u5916\u4e00\u4e2a\u91cd\u8981\u529f\u80fd\uff1a\u5b83<strong>\u80fd\u591f\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u4fee\u590dDNA\u635f\u4f24\u7684\u80fd\u529b\uff0c\u4e0ePARP\u6291\u5236\u5242\u8054\u7528\uff0c\u53ef\u80fd\u8fbe\u5230\u66f4\u597d\u7684\u6297\u764c\u6548\u679c<\/strong>\u3002\u8fd9\u9879\u7814\u7a76\u53d1\u8868\u5728\u6700\u65b0\u7684<em>Science Translational Medicine<\/em>\u4e0a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558315619.jpg\" alt=\"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01\" title=\"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u6700\u8fd1\u7684\u4e00\u98792\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0ccediranib\u4e0ePARP\u6291\u5236\u5242olaparib\u8054\u7528\uff0c\u6cbb\u7597\u590d\u53d1\u6027\u5375\u5de2\u764c\u60a3\u8005\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c<strong>cediranib\u548colaparib\u8054\u7528<\/strong>\uff0c\u4e0d\u4f46\u5bf9\u643a\u5e26<em>BRCA<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u4ea7\u751f\u826f\u597d\u7597\u6548\uff0c\u4e5f<strong>\u63d0\u9ad8\u4e86\u4e0d\u643a\u5e26<em>BRCA<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09<\/strong>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Olaparib\u662f\u7b2c\u4e00\u6b3e\u83b7\u6279\u7684PARP\u6291\u5236\u5242\uff0c\u5b83\u662f\u57fa\u4e8e\u201c\u5408\u6210\u81f4\u6b7b\u201d\u539f\u5219\u5f00\u53d1\u7684\u6297\u764c\u836f\u7269\u3002\u901a\u5e38\uff0colaparib\u53ea\u4f1a\u5728\u643a\u5e26<em>BRCA<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\u8d77\u4f5c\u7528\u3002\u8fd9\u4e00\u8bd5\u9a8c\u7ed3\u679c\u8ba9\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u5bfb\u627ecediranib\u548colaparib\u7ec4\u5408\u7597\u6cd5\u63d0\u9ad8\u60a3\u8005PFS\u7684\u539f\u56e0\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6700\u521d\u4ed6\u4eec\u4ee5\u4e3a\uff0c\u7ec4\u5408\u7597\u6cd5\u7684\u6548\u679c\u662f\u7531\u4e8ecediranib\u6291\u5236\u8840\u7ba1\u589e\u751f\u7684\u540e\u679c\u3002\u7136\u800c\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0ccediranib\u9664\u4e86\u80fd\u591f\u6291\u5236\u8840\u7ba1\u589e\u751f\u4ee5\u5916\uff0c\u8fd8\u80fd\u591f\u901a\u8fc7\u6291\u5236\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08PDGFR\uff09\u7684\u529f\u80fd\uff0c\u6291\u5236<em>BRCA1\/2<\/em>\u548c<em>RAD51<\/em>\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u800c\u8fd9\u4e9b\u57fa\u56e0\u5728\u4ecb\u5bfc\u540c\u6e90\u91cd\u7ec4DNA\u4fee\u590d\u65b9\u9762\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u8fd9\u610f\u5473\u7740<strong>cediranib\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u540c\u6e90\u91cd\u7ec4DNA\u4fee\u590d\u673a\u5236\uff0c\u8ba9\u80bf\u7624\u5bf9olaparib\u66f4\u4e3a\u654f\u611f<\/strong>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558315619.jpg\" alt=\"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01\" title=\"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<h1  style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2\u5728\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0ccediranib\u548colaparib\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5\u663e\u8457\u7f29\u5c0f\u80bf\u7624\u5927\u5c0f\uff0c\u63d0\u9ad8\u5c0f\u9f20\u751f\u5b58\u671f\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u66f4\u4e3a\u53ef\u559c\u7684\u662f\uff0c\u5728\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0ccediranib\u5bfc\u81f4\u7684\u57fa\u56e0\u8868\u8fbe\u4e0b\u8c03\u53ea\u51fa\u73b0\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u800c\u4e0d\u51fa\u73b0\u5728\u5c0f\u9f20\u9aa8\u9ad3\u4e2d\u3002\u8fd9\u589e\u5f3a\u4e86cediranib\u548colaparib\u7ec4\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u4f7f\u7528cediranib\u5e2e\u52a9\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684DNA\u4fee\u590d\u80fd\u529b\u53ef\u80fd\u5bf9\u4f9d\u9760\u8fd9\u4e00\u4fe1\u53f7\u901a\u8def\u7684\u591a\u79cd\u764c\u75c7\u6709\u6548\uff0c\u201d\u8fd9\u9879\u7814\u7a76\u7684\u7b2c\u4e00\u4f5c\u8005\uff0c\u8036\u9c81\u5927\u5b66\u7684\u535a\u58eb\u751fAlanna Kaplan\u5973\u58eb\u8bf4\u3002\u7814\u7a76\u4eba\u5458\u73b0\u5728\u7684\u76ee\u6807\u662f\u7814\u7a76\u8fd9\u4e00\u201c\u5408\u6210\u81f4\u6b7b\u201c\u7ec4\u5408\u7597\u6cd5\u80fd\u5426\u6269\u5c55\u5230\u7528\u4e8e\u6cbb\u7597\u5176\u5b83\u7c7b\u578b\u7684\u764c\u75c7\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Kaplan et al, (2019). Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1\/2 and RAD51. Science Translational Medicine. DOI: 10.1126\/scitranslmed.aav4508<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Yale study identifies how cancer drug inhibits DNA repair in cancer cells. Retrieved May 16, 2019, from https:\/\/www.eurekalert.org\/pub_releases\/2019-05\/yu-ysi051419.php<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"__bg_gif\"      style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558315619.gif\" alt=\"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01\" title=\"\u524d\u6cbf |\u300a\u79d1\u5b66\u300b\u5b50\u520a\uff1a\u8fd9\u6b3e\u6297\u764c\u65b0\u836f\uff0c\u4e0d\u4f46\u6291\u5236\u8840\u7ba1\u589e\u751f\uff0c\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u6297\u764c\u673a\u5236\uff01\"  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 Cediranib\u662f\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3eVEGF\u53d7\u4f53\u6291\u5236\u5242\uff0c\u7136\u800c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":111825,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111824"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=111824"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111824\/revisions"}],"predecessor-version":[{"id":111829,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/111824\/revisions\/111829"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/111825"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=111824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=111824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=111824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}