{"id":112182,"date":"2019-05-17T00:00:50","date_gmt":"2019-05-20T01:29:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/112182\/"},"modified":"2019-05-20T09:29:50","modified_gmt":"2019-05-20T01:29:50","slug":"fd01181a80","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/112182\/","title":{"rendered":"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 30px;max-width: 100%;border-width: 1px;border-style: solid;border-color: rgb(208, 169, 115);width: 529.82px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: 5px -6px -6px 5px;padding: 5px 15px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;border-width: 1px;border-style: solid;border-color: rgb(192, 192, 192);\">\n<section style=\"margin-top: -30px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"padding: 5px 10px;max-width: 100%;display: inline-block;background: rgb(208, 169, 115);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(255, 255, 255);min-width: 1em;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6458\u8981<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\">\u57fa\u4e8e\u4ee3\u8c22\u7ec4\u5b66\u65b9\u6cd5\u80fd\u8f83\u4e3a\u76f4\u89c2\u548c\u5b8c\u6574\u5730\u5448\u73b0\u4f53\u5916\u590d\u6742\u4f53\u7cfb\u4e2d\u5316\u5b66\u6210\u5206\u7684\u8f6e\u5ed3\u5dee\u5f02\u53ca\u5176\u5728\u4f53\u5185\u5438\u6536\u3001\u5206\u5e03\u548c\u4ee3\u8c22\u7684\u5dee\u5f02\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u4ee3\u8c22\u7ec4\u5b66\u5df2\u7ecf\u6210\u4e3a\u5f53\u4eca\u751f\u7269\u4e0e\u533b\u836f\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u5176\u4f5c\u4e3a\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u6838\u5fc3\u7ec4\u5b66\uff0c\u4e0e\u5176\u4ed6\u7ec4\u5b66\u8fdb\u884c\u7684\u7cfb\u7edf\u6027\u7814\u7a76\u4e3a\u4e2d\u836f\u4f5c\u7528\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u4e86\u601d\u8def\u548c\u65b9\u6cd5[1]\u3002\u4ee3\u8c22\u7ec4\u5b66\u5df2\u7ecf\u5728\u4e34\u5e8a\u75be\u75c5\u8bca\u65ad\u53ca\u91cd\u5927\u75be\u75c5\u7684\u65e9\u671f\u8bca\u65ad\u7b49\u9886\u57df\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\u3002\u5728\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\u4e2d\u6700\u5e38\u91c7\u7528\u7684\u6280\u672f\u4e3a\u6838\u78c1\u5171\u632f\uff08NMR, nuclear magnetic resonance\uff09[2]\u548c\u8d28\u8c31\uff08MS, mass spectrometry\uff09[3]\u5206\u6790\u6280\u672f\u3002\u5f80\u5f80\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\u8272\u8c31\u5206\u79bb\u6280\u672f\uff0c\u5982\u6c14\u8d28(gas chromatography, GC)\u3001\u6db2\u76f8(liquid chromatography, LC)\u548c\u6bdb\u7ec6\u7ba1\u7535\u6cf3\uff08capillary elctrophoresis, CE)\uff0c\u5b83\u4eec\u5e38\u4e0e\u8d28\u8c31\u4e32\u8054\u8d77\u6765\u5206\u6790\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 24px;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558315786.jpeg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><span style=\"font-size: 14px;\">\u56fe1&nbsp;\u4e09\u79cd\u5206\u6790\u65b9\u6cd5\u7b56\u7565\u6d41\u7a0b\u56fe<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 16px;\">\u57fa\u4e8e\u6c14\u76f8\u8272\u8c31\u548c\u6db2\u76f8\u8272\u8c31\u4e0e\u9ad8\u5206\u8fa8\u8d28\u8c31\u8054\u7528\u6280\u672f\u7684\u5206\u6790\u7b56\u7565\u4e3b\u8981\u6709\uff08\u56fe1\uff09\uff1a\u76ee\u6807\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\uff08Target analysis\uff09\u3001\u975e\u76ee\u6807\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\uff08Un-target analysis\uff09\u548c\u53ef\u7591\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\uff08Suspect analysis\uff09[4]\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 16px;\">\u5229\u7528\u975e\u76ee\u6807\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\u7b5b\u9009\u7ed3\u679c\u53ef\u4ee5\u6269\u5c55\u548c\u7cbe\u70bc\u76ee\u6807\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\u6240\u7814\u7a76\u7684\u5bf9\u8c61[5]\u3002\u5bf9\u4e8e\u91c7\u96c6\u7684\u6570\u636e\u5305\u542b\u7684\u4fe1\u606f\u5f80\u5f80\u90fd\u6bd4\u8f83\u5e9e\u6742\uff0c\u6570\u636e\u9884\u5904\u7406\u8fc7\u7a0b\u548c\u6570\u636e\u5206\u6790\u662f\u81f3\u5173\u91cd\u8981\u7684\u73af\u8282\uff0c\u8fd9\u5c06\u76f4\u63a5\u5f71\u54cd\u5230\u6700\u7ec8\u6570\u636e\u5206\u6790\u7684\u7ed3\u679c\u3002\u6570\u636e\u9884\u5904\u7406\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u7684\u8f6f\u4ef6\u5927\u81f4\u5206\u4e3a\u5546\u54c1\u5316\u8f6f\u4ef6\uff08\u5982Markerlynx\u3001MassHunter\u3001AMDIS\u548cChromaTOF\uff09\u548c\u514d\u8d39\u7684\u8f6f\u4ef6\uff08\u5982Mzmine[6,&nbsp;7]\uff0cXCMS[8-10]\uff0cMSFACTS[11]\u548cMetAlign[12]\u7b49\uff09\u4e24\u5927\u7c7b\uff0c\u5b83\u4eec\u53ef\u4ee5\u5c06\u539f\u59cb\u6570\u636e\u8fdb\u884c\u5cf0\u53bb\u5377\u79ef\u3001\u6807\u51c6\u5316\u548c\u5cf0\u5bf9\u9f50\u7b49\u5904\u7406\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 16px;\">\u7d27\u63a5\u7740\uff0c\u4ee3\u8c22\u7ec4\u5b66\u4e2d\u5e38\u91c7\u7528\u7684\u591a\u5143\u7edf\u8ba1\u5206\u6790\uff0c\u80fd\u591f\u5bf9\u5e9e\u5927\u7684\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u53d1\u73b0\u6837\u54c1\u4e4b\u95f4\u6216\u5404\u7ec4\u4e4b\u95f4\u7684\u5f02\u540c[13]\u3002\u65e0\u76d1\u7763\u6a21\u5f0f\u4e0b\u7684PCA\u548c\u6709\u76d1\u7763\u6a21\u5f0f\u4e0b\u7684OPLS-DA\u5747\u662f\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u5e38\u4f7f\u7528\u7684\u4e00\u79cd\u5206\u7c7b\u65b9\u6cd5[14,&nbsp;15]\u3002\u6bd4\u5982\u6211\u4eec\u4ee5\u4e2d\u836f\u9ec4\u82a9\u4e3a\u4f8b\uff0c\u8fd0\u7528\u975e\u9776\u5411\u4ee3\u8c22\u7ec4\u5b66\u624b\u6bb5\u7ed3\u5408Q exactive MS\u5206\u6790\u65b9\u6cd5\u7814\u7a76\u4e0d\u540c\u89c4\u683c\u9ec4\u82a9\uff08\u67af\u82a9\u548c\u5b50\u82a9\uff09\u6837\u54c1\u4e4b\u95f4\u5dee\u5f02\u6027\u7684\u6d3b\u6027\u6210\u5206\uff0c\u7814\u7a76\u601d\u8def\u5982\u56fe2\u6240\u793a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558315787.jpeg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe2&nbsp;\u57fa\u4e8e\u4ee3\u8c22\u7ec4\u5b66\u7684\u7814\u7a76\u65b9\u6cd5\u5e94\u7528\u4e8e\u4e2d\u836f\u9ec4\u82a9[16]<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;height: 1.8em;width: 1.8em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(240, 84, 84);font-size: 1.6em;text-align: center;color: rgb(240, 84, 84);background-color: rgb(254, 254, 254);transform: rotate(0deg);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e00<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: -1.56em;margin-bottom: 1em;margin-left: 0.5em;max-width: 100%;border-radius: 1em;font-size: 1.2em;color: rgb(255, 255, 255);border-color: rgb(255, 140, 0);background-color: rgb(240, 84, 84);z-index: -1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 5px;margin-left: 5px;padding-right: 10px;padding-left: 2em;max-width: 100%;display: inline-block;vertical-align: top;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 1em;min-width: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f53\u5916\u836f\u6750\u6837\u54c1\u7684\u5236\u5907<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u4ee5\u4e2d\u836f\u6750\u4e3a\u4f8b\uff0c\u6837\u54c1\u7684\u5236\u5907\u5e94\u6839\u636e\u6837\u54c1\u81ea\u8eab\u7684\u7279\u6027\uff0c\u4f18\u9009\u6700\u4f73\u7684\u63d0\u53d6\u65b9\u6cd5\uff08\u5982\u8d85\u58f0\u63d0\u53d6\u3001\u56de\u6d41\u63d0\u53d6\u7b49\uff09\u548c\u6eb6\u5242\u3002\u5e38\u7528\u7684\u63d0\u53d6\u6eb6\u5242\u4e3a\u6c34\u3001\u7532\u9187\u3001\u4e59\u9187\u3001\u4e59\u9178\u4e59\u916f\u3001\u6c2f\u4eff\u7b49\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u6ce8\u610f\u4e8b\u9879\uff1a\u524d\u671f\u6837\u54c1\u5236\u5907\u65b9\u6cd5\u53ef\u4ee5\u91c7\u7528\u5355\u56e0\u7d20\u6216\u6b63\u4ea4\u5b9e\u9a8c\u8fdb\u884c\u6761\u4ef6\u4f18\u5316\uff1b\u5982\u679c\u91c7\u7528\u8d85\u58f0\u63d0\u53d6\uff0c\u5e94\u5ba2\u89c2\u8bc4\u5224\u8d85\u58f0\u529f\u7387\u548c\u8d85\u58f0\u65f6\u95f4\u5f15\u8d77\u6c34\u6d74\u6e29\u5ea6\u5347\u9ad8\u5bf9\u63d0\u53d6\u6837\u54c1\u7684\u5f71\u54cd\uff1b\u5e94\u8be5\u5145\u5206\u8bc4\u4ef7\u63d0\u53d6\u6837\u54c1\u6240\u5e26\u6765\u7684\u64cd\u4f5c\u8bef\u5dee\u5bf9\u5b9e\u9a8c\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;height: 1.8em;width: 1.8em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(240, 84, 84);font-size: 1.6em;text-align: center;color: rgb(240, 84, 84);background-color: rgb(254, 254, 254);transform: rotate(0deg);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e8c<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: -1.56em;margin-bottom: 1em;margin-left: 0.5em;max-width: 100%;border-radius: 1em;font-size: 1.2em;color: rgb(255, 255, 255);border-color: rgb(255, 140, 0);background-color: rgb(240, 84, 84);z-index: -1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 5px;margin-left: 5px;padding-right: 10px;padding-left: 2em;max-width: 100%;display: inline-block;vertical-align: top;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 1em;min-width: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u751f\u7269\u6837\u54c1\u7684\u5236\u5907<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u751f\u7269\u6837\u54c1\u4e3b\u8981\u5305\u62ec\u4f53\u6db2\uff08\u5168\u8840\u3001\u8840\u6d46\u3001\u8840\u6e05\u3001\u5c3f\u6db2\u3001\u553e\u6db2\u548c\u8111\u810a\u6db2\u7b49\uff09\u3001\u7ec4\u7ec7\uff08\u8111\u3001\u5fc3\u3001\u809d\u3001\u813e\u3001\u80ba\u3001\u80be\u3001\u80f8\u817a\u3001\u80f0\u817a\u3001\u5c0f\u80a0\u3001\u5927\u80a0\u3001\u808c\u8089\u548c\u9aa8\u9abc\u7b49\uff09\u4ee5\u53ca\u5176\u5b83\uff08\u6bdb\u53d1\u548c\u7caa\u4fbf\u7b49\uff09\u6837\u54c1\u3002\u4e0d\u540c\u7c7b\u578b\u6837\u54c1\u524d\u5904\u7406\u65b9\u5f0f\u6709\u6240\u4e0d\u540c\u3002\u5e38\u89c1\u7684\u751f\u7269\u6837\u54c1\u524d\u5904\u7406\u65b9\u6cd5\uff1a\u5305\u62ec\u86cb\u767d\u6c89\u6dc0\uff08PP\uff09\u3001\u6db2\u6db2\u8403\u53d6\uff08LLE\uff09\u548c\u56fa\u76f8\u8403\u53d6\uff08SPE\uff09\u6cd5\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u6ce8\u610f\u4e8b\u9879\uff1a\u5e94\u5145\u5206\u8bc4\u4ef7\u63d0\u53d6\u6837\u54c1\u6240\u5e26\u6765\u7684\u64cd\u4f5c\u8bef\u5dee\u5bf9\u5b9e\u9a8c\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u6709\u5fc5\u8981\u9700\u8bbe\u5b9a\u8d28\u63a7\u6837\u54c1\uff1b\u9700\u8003\u8651\u6837\u54c1\u6536\u96c6\u8fc7\u7a0b\u4e2d\u7a33\u5b9a\u6027\u95ee\u9898\uff0c\u5982\u5c3f\u6db2\u6837\u54c1\u7684\u6536\u96c6\uff0c\u57fa\u8d28\u4e2d\u9176\u3001\u5149\u7167\u53ca\u6e29\u5ea6\u5bf9\u6837\u54c1\u7684\u5f71\u54cd\uff1b\u9700\u8003\u8651\u6837\u54c1\u524d\u5904\u7406\u8fc7\u7a0b\u4e2d\u5438\u9644\u6027\u95ee\u9898\uff0c\u5982\u8111\u810a\u6db2\uff08CSF\uff09\u548c\u5c3f\u6db2\u4e2d\u56e0\u4e3a\u86cb\u767d\u542b\u91cf\u8f83\u4f4e\uff0c\u8f83\u6613\u4e0e\u6837\u54c1\u6536\u96c6\u7ba1\u7531\u4e8e\u8868\u9762\u7535\u8377\u4ea7\u751f\u76f8\u4e92\u5438\u9644\u4ee5\u53ca\u8d28\u63a7\u6837\u54c1\u5236\u5907\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;height: 1.8em;width: 1.8em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(240, 84, 84);font-size: 1.6em;text-align: center;color: rgb(240, 84, 84);background-color: rgb(254, 254, 254);transform: rotate(0deg);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e09<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: -1.56em;margin-bottom: 1em;margin-left: 0.5em;max-width: 100%;border-radius: 1em;font-size: 1.2em;color: rgb(255, 255, 255);border-color: rgb(255, 140, 0);background-color: rgb(240, 84, 84);z-index: -1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 5px;margin-left: 5px;padding-right: 10px;padding-left: 2em;max-width: 100%;display: inline-block;vertical-align: top;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 1em;min-width: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u91c7\u96c6\u6570\u636e\u7684\u9884\u5904\u7406<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u76ee\u524d\uff0c\u5bf9\u4e8eLC\/GC-MS\u91c7\u96c6\u7684\u6570\u636e\u8fdb\u884c\u9884\u5904\u7406\u7684\u8f6f\u4ef6\u975e\u5e38\u4e4b\u591a\uff0c\u6709\u514d\u8d39\u5f00\u6e90\u7684\uff08\u5982XCMS\uff0cMZmine\u548cMetAlign\u7b49\uff09\u3001\u5546\u4e1a\u6536\u8d39\u7684\uff08Markerlynx\uff0cMassHunter\uff0cChromaTOF\u548cChemPattern 2.0\u7b49\uff09\u548c\u81ea\u4e3b\u5f00\u53d1\u8bbe\u8ba1\u7684\u7f16\u7a0b\u8f6f\u4ef6\uff08\u5982Metlab\uff09\u3002\u6bcf\u4e00\u79cd\u8f6f\u4ef6\u90fd\u6709\u5404\u81ea\u7684\u4f18\u7f3a\u70b9\uff0c\u9700\u8981\u6309\u7167\u81ea\u5df1\u7684\u76ee\u7684\u6216\u9700\u6c42\u8fdb\u884c\u9009\u62e9\u3002\u5176\u4e2d\uff0cXCMS\u662f\u4e00\u4e2a\u514d\u8d39\u7684R\u8f6f\u4ef6\u5305\uff0c\u53ef\u7528\u4e8eLC\/MS\u6216GC\/MS\u6570\u636e\u5904\u7406\uff0c\u662f\u76ee\u524d\u4f7f\u7528\u6700\u4e3a\u5e7f\u6cdb\uff0c\u5f15\u7528\u6587\u732e\u6700\u591a\u7684\u4e00\u4e2a\u8f6f\u4ef6[17]\u3002XCMS online\uff09\uff08\u56fe3\uff09\u662f\u57fa\u4e8e\u4e91\u8ba1\u7b97\u7684\u5728\u7ebf\u7248\u672c\uff08https:\/\/xcmsonline.scripps.edu\/\uff09\uff0c\u4e0d\u9700\u8981\u4e0b\u8f7d\u5b89\u88c5\uff0c\u5141\u8bb8\u7528\u6237\u5728\u7ebf\u4e0a\u4f20LC\/MS\u6216GC\/MS\u6570\u636e\uff08\u683c\u5f0f\u5982NetCDF\uff0cmzXML\u548cmzData\u7b49\uff09\uff0c\u5982\u6309\u7167\u81ea\u5b9a\u4e49\u9009\u9879\u8bbe\u7f6e\u76f8\u5173\u53c2\u6570\u540e\uff0c\u5c31\u53ef\u5728\u7ebf\u67e5\u770b\u548c\u5206\u6790\u7ed3\u679c[8-10,&nbsp;18]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 24px;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5bf9\u9884\u5904\u7406\u540e\u6570\u636e\u91c7\u7528Excel\u7684COUNTIF\u51fd\u6570\u5bf9\u539f\u59cb\u6570\u636e\u8fdb\u884c\u7b5b\u9009\u53bb\u9664\u96f6\uff0c\u9664\u96f6\u539f\u5219\u6839\u636e\u81ea\u8eab\u8981\u6c42\u800c\u5b9a\uff0c\u5e38\u752880-20\u539f\u5219\uff0c\u5373\u4fdd\u7559\u6837\u54c1\u4e2d\u542b\u670920%\u4ee5\u4e0b\u4e3a\u96f6\u7684\u6570\u636e\u3002\u7136\u540e\u8fdb\u884c\u591a\u5143\u7edf\u8ba1\u5206\u6790\uff08\u5982PCA\u548cOPLS-DA\uff09\u5f97\u5230VIP\uff08\u22651\uff09\u503c\u8868\uff0c\u91c7\u7528Excel\u7684VLOOKUP\u51fd\u6570\u5bf9\u627e\u5230\u7684VIP\u503c\u22651\u7684\u6570\u636e\u548c\u539f\u59cb\u6570\u636e\u8fdb\u884c\u5339\u914d\uff0c\u5e76\u5217\u51fa\u6bcf\u4e00\u4e2am\/z\u4e0b\u7684\u539f\u59cb\u6570\u636e\u4fe1\u606f\uff0c\u4ee5\u4fbf\u4e8e\u7504\u9009\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558315788.jpeg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe3 XCMS Online\u8f6f\u4ef6\u754c\u9762<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;height: 1.8em;width: 1.8em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(240, 84, 84);font-size: 1.6em;text-align: center;color: rgb(240, 84, 84);background-color: rgb(254, 254, 254);transform: rotate(0deg);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u56db<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: -1.56em;margin-bottom: 1em;margin-left: 0.5em;max-width: 100%;border-radius: 1em;font-size: 1.2em;color: rgb(255, 255, 255);border-color: rgb(255, 140, 0);background-color: rgb(240, 84, 84);z-index: -1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 5px;margin-left: 5px;padding-right: 10px;padding-left: 2em;max-width: 100%;display: inline-block;vertical-align: top;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 1em;min-width: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u591a\u5143\u7edf\u8ba1\u5206\u6790<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u4ee3\u8c22\u7ec4\u5b66\u4e2d\u8fd0\u7528\u7684\u591a\u5143\u7edf\u8ba1\u5206\u6790\u65b9\u6cd5\u4e3b\u8981\u5305\u62ec\u65e0\u76d1\u7763\u5206\u6790\uff08unsupervised analysis\uff09\u65b9\u6cd5\uff08\u5982PCA\uff0cHCA\uff09\u548c\u6709\u76d1\u7763\u5206\u6790\uff08supervised analysis\uff09\u65b9\u6cd5\uff08\u5982PLS\uff0cPLS-DA\uff0cOPLS\uff0c\u548cOPLS-DA\uff09\u3002\u65e0\u76d1\u7763\u5206\u6790\u65b9\u6cd5\u662f\u6307\u6240\u6709\u6837\u54c1\u4e0d\u52a0\u4ee5\u533a\u5206\uff0c\u6bcf\u4e2a\u6837\u54c1\u90fd\u5bf9\u6a21\u578b\u6709\u7740\u540c\u6837\u7684\u8d21\u732e\u3002\u5bf9\u4e8e\u7ec4\u95f4\u5dee\u5f02\u8f83\u5927\uff0c\u800c\u7ec4\u5185\u5dee\u5f02\u8f83\u5c0f\u65f6\uff0c\u65e0\u76d1\u7763\u5206\u6790\u65b9\u6cd5\u53ef\u4ee5\u660e\u663e\u533a\u5206\u7ec4\u95f4\u5dee\u5f02\u3002\u53cd\u4e4b\uff0c\u7ec4\u95f4\u5dee\u5f02\u4e0d\u660e\u663e\uff0c\u800c\u7ec4\u5185\u5dee\u5f02\u8f83\u5927\uff0c\u65e0\u76d1\u7763\u6a21\u5f0f\u5c31\u96be\u4ee5\u53d1\u73b0\u548c\u533a\u5206\u7ec4\u95f4\u5dee\u5f02\u3002\u539f\u56e0\u5728\u4e8e\uff0c\u65e0\u76d1\u7763\u5206\u6790\u65b9\u6cd5\u4e0d\u80fd\u5ffd\u7565\u7ec4\u5185\u8bef\u5dee\uff0c\u6d88\u9664\u4e0e\u7814\u7a76\u76ee\u7684\u65e0\u5173\u7684\u968f\u673a\u8bef\u5dee\uff0c\u8fc7\u4e8e\u5173\u6ce8\u4e8e\u5c40\u90e8\u6216\u7ec6\u8282\uff0c\u5ffd\u7565\u5bf9\u8c61\u7684\u6574\u4f53\u53ca\u5176\u89c4\u5f8b\uff0c\u56e0\u6b64\uff0c\u4e0d\u5229\u4e8e\u53d1\u73b0\u7ec4\u95f4\u5dee\u5f02\u548c\u5dee\u5f02\u6027\u5316\u5408\u7269\uff0c\u800c\u8fd9\u6b63\u662f\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\u6700\u91cd\u8981\u7684\u76ee\u7684\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u4e8e\u662f\u4e4e\u6709\u76d1\u7763\u5206\u6790\u65b9\u6cd5\u8fd9\u7c7b\u65b0\u7684\u5206\u6790\u6280\u672f\u5e94\u8fd0\u800c\u751f\uff0c\u80fd\u591f\u5f88\u597d\u5730\u89e3\u51b3\u4e0a\u8ff0\u5b58\u5728\u7684\u95ee\u9898\u3002\u539f\u56e0\u662f\u5176\u5148\u5c06\u68c0\u6d4b\u6837\u54c1\u8fdb\u884c\u5206\u7c7b\u533a\u5206\uff0c\u518d\u8fdb\u884c\u5206\u6790\uff0c\u8fd9\u6837\u5728\u8ba1\u7b97\u65f6\u5c31\u5ffd\u7565\u6837\u54c1\u95f4\u7ec4\u5185\u968f\u673a\u5dee\u5f02\uff0c\u7a81\u51fa\u7ec4\u95f4\u7cfb\u7edf\u5dee\u5f02[13]\u3002\u76ee\u524d\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\u8bc4\u4ef7\u4e2d\u5e94\u7528\u6700\u4e3a\u5e38\u7528\u7684\u6a21\u5f0f\u8bc6\u522b\u65b9\u6cd5\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u548c\u6b63\u4ea4\u504f\u6700\u5c0f\u4e8c\u4e58\u5224\u522b\u5206\u6790\uff08OPLS-DA\uff09\uff0c\u5982\u56fe4\u6240\u793a\u3002OPLS-DA\u4e3aPLS-DA\u7684\u6539\u8fdb\u65b9\u6cd5\uff0c\u6ee4\u6389\u4e0e\u7c7b\u522b\u5224\u65ad\u4e0d\u76f8\u5173\u7684\u53d8\u91cf\u4fe1\u606f\uff0c\u63d0\u9ad8\u6a21\u578b\u5224\u522b\u7684\u51c6\u786e\u6027\u3002\u91c7\u7528\u7684\u591a\u5143\u7edf\u8ba1\u8f6f\u4ef6\u4e3aSIMCA P\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558315788.jpeg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><span style=\"font-size: 14px;\">\u56fe4&nbsp;\u5178\u578b\u7684PCA\uff08A\u548cD\uff09\u3001OPLS-DA\uff08B\u548cE\uff09\u548cS-Plot\uff08C\u548cF\uff09\u56fe[16]<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 24px;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">OPLS-DA\u6a21\u578b\u6982\u8ff0\u56fe\u4e2dR2Y\uff08cum\uff09\u8868\u793a\u6a21\u578b\u6bcf\u6b21\u8fdb\u884c\u5206\u7c7b\u540e\u5bf9\u6240\u6709\u56e0\u53d8\u91cfY\u53d8\u5316\u8fdb\u884c\u8bf4\u660e\u90e8\u5206\uff1bQ2\uff08cum\uff09\u8868\u793a\u53ef\u4ee5\u901a\u8fc7\u6a21\u578b\u7684\u4ea4\u53c9\u9a8c\u8bc1\u8fdb\u884c\u9884\u6d4b\u56e0\u53d8\u91cfY\u53d8\u5316\u7684\u90e8\u5206\u3002R2Y\uff08cum\uff09\u548cQ2\uff08cum\uff09\u63a5\u8fd11.0\u8bf4\u660e\u6a21\u578b\u5efa\u7acb\u5b8c\u7f8e\u3002PCA\u548cOPLS-DA\u6a21\u578b\u4e0b\uff0c\u6211\u4eec\u5e38\u6839\u636e\u5b9e\u9645\u60c5\u51b5\u91c7\u7528UV\u3001Par\u548cCtr\u4e09\u79cd\u6807\u5ea6\u5316\u7c7b\u578b\uff08\u88681\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u88681&nbsp;\u4e0d\u540c\u7c7b\u578b\u6807\u5ea6\u5316\uff08Scaling type\uff09\u53ca\u5176\u5b9a\u4e49<\/span><\/p>\n<table width=\"676\" style=\"width: 556px;\">\n<tbody style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"129\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top-color: windowtext;border-bottom-color: windowtext;max-width: 100%;background: rgb(216, 216, 216);overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6807\u5ea6\u5316\u7c7b\u578b<\/span><\/strong><\/p>\n<\/td>\n<td width=\"302.3333333333333\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top-color: windowtext;border-bottom-color: windowtext;max-width: 100%;background: rgb(216, 216, 216);overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5b9a\u4e49<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"129\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top: none;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">UV\u81ea\u6807\u5ea6\u5316<\/span><\/p>\n<\/td>\n<td width=\"302.3333333333333\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top: none;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u6bcf\u4e2a\u53d8\u91cf\u5404\u81ea\u7684\u65b9\u5dee\u8fdb\u884c\u4e2d\u503c\u5316\u548c\u6807\u5ea6\u5316<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"121.33333333333333\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Par (Pareto)<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\u6807\u5ea6\u5316<\/span><\/span><\/p>\n<\/td>\n<td width=\"302.3333333333333\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53d8\u91cf\u4e2d\u503c\u5316\u4f46\u662f\u672a\u6807\u5ea6\u5316<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"129\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-bottom-color: windowtext;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Ctr\u4e2d\u503c\u6807\u5ea6\u5316<\/span><\/p>\n<\/td>\n<td width=\"302.3333333333333\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-bottom-color: windowtext;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u6bcf\u4e2a\u53d8\u91cf\u5404\u81ea\u7684\u6807\u51c6\u5dee\u8fdb\u884c\u4e2d\u503c\u5316\u548c\u6807\u5ea6\u5316<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;height: 1.8em;width: 1.8em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(240, 84, 84);font-size: 1.6em;text-align: center;color: rgb(240, 84, 84);background-color: rgb(254, 254, 254);transform: rotate(0deg);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e94<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: -1.56em;margin-bottom: 1em;margin-left: 0.5em;max-width: 100%;border-radius: 1em;font-size: 1.2em;color: rgb(255, 255, 255);border-color: rgb(255, 140, 0);background-color: rgb(240, 84, 84);z-index: -1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 5px;margin-left: 5px;padding-right: 10px;padding-left: 2em;max-width: 100%;display: inline-block;vertical-align: top;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 1em;min-width: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5316\u5b66\u6210\u5206\u7684\u89e3\u6790<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u975e\u9776\u6807\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\u57fa\u672c\u6d41\u7a0b\u4e3a\u6837\u54c1\u524d\u5904\u7406\u7684\u9009\u62e9\u548c\u4f18\u5316\u3001\u4eea\u5668\u5206\u6790\uff08\u5168\u626b\u63cf\uff09\u3001\u6570\u636e\u5904\u7406\uff08\u9884\u5904\u7406\u3001\u591a\u5143\u7edf\u8ba1\u5206\u6790\uff09\u3001\u76ee\u6807\u5316\u5408\u7269\u7684\u4e8c\u7ea7\u56fe\u8c31\u626b\u63cf\u3001\u7ed3\u6784\u6307\u8ba4[5]\u3002\u5404\u5382\u5bb6\u7684\u9ad8\u5206\u8fa8\u8d28\u8c31\u4eea\uff08HRMS\uff09\u7c7b\u578b\u4e3b\u8981\u6709Q-TOF\uff0cIT-TOF\u548cOrbitrap\u7b49\u7cfb\u5217\u3002\u5176\u4e2d\uff0c\u5982Q Exactive MS\u662f\u65b0\u578b\u56db\u7ea7\u6746\u548c\u8f68\u9053\u9631\u6742\u4ea4HRMS\uff0c\u5728\u5206\u8fa8\u7387\u3001\u626b\u63cf\u901f\u5ea6\u548c\u7075\u654f\u5ea6\u6027\u80fd\u4e0a\u8fdb\u4e00\u6b65\u63d0\u5347\uff0cQ Exactive\u8d28\u8c31\u4eea\u80fd\u8fdb\u884c\u9ad8\u901a\u91cf\u7684\u76ee\u6807\u7269\u6216\u975e\u76ee\u6807\u7269\u7684\u7b5b\u9009[19]\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u88682&nbsp;\u6570\u636e\u89e3\u6790\u53c2\u8003\u6570\u636e\u5e93\u4fe1\u606f<\/span><\/p>\n<table width=\"676\" style=\"width: 556px;\">\n<tbody style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"122\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top-color: windowtext;border-bottom-color: windowtext;max-width: 100%;background: rgb(216, 216, 216);overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6570\u636e\u5e93\u540d\u79f0<\/span><\/strong><\/p>\n<\/td>\n<td width=\"228\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top-color: windowtext;border-bottom-color: windowtext;max-width: 100%;background: rgb(216, 216, 216);overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6570\u636e\u5e93\u7f51\u5740<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"122\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top: none;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Massbank<\/span><\/p>\n<\/td>\n<td width=\"228\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-top: none;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/www.massbank.jp\/<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"122\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ChemSpider<\/span><\/p>\n<\/td>\n<td width=\"228\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/www.chemspider.com\/<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"122\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">SCIfinder<\/span><\/p>\n<\/td>\n<td width=\"228\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">https:\/\/origin-scifinder.cas.org\/<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"122\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">TCM database<\/span><\/p>\n<\/td>\n<td width=\"228\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/tcm.cmu.edu.tw\/<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<td width=\"122\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-bottom-color: windowtext;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ChemicalBook<\/span><\/p>\n<\/td>\n<td width=\"228\" valign=\"top\" style=\"padding: 0px 7px;word-break: break-all;border-bottom-color: windowtext;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/www.chemicalbook.com\/<\/span><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"max-width: 100%;min-height: 1em;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u6839\u636e\u76ee\u6807\u5dee\u5f02\u6027\u6210\u5206MS\u6570\u636e\u8fdb\u884cMS\/MS\u626b\u63cf\uff0c\u5e76\u7ed3\u5408\u6570\u636e\u5e93\uff08\u5e38\u7528\u7684\u6570\u636e\u5e93\u5982\u88682\u6240\u793a\uff09\u548c\u6587\u732e\u62a5\u9053\uff08\u6bd4\u5982\u9ec4\u916e\u7c7b\u6210\u5206\u9ec4\u916e\u82f7\u5143\u3001\u6c27\u82f7\u548c\u78b3\u82f7\u7684\u88c2\u89e3\u89c4\u5f8b\uff0c\u5982\u56fe5\u6240\u793a\uff09\u5bf9\u8fd9\u4e9b\u6210\u5206\u8fdb\u884c\u7ed3\u6784\u89e3\u6790\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558315789.jpeg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><span style=\"font-size: 14px;\">&nbsp;\u56fe5&nbsp;\u9ec4\u916e\u7c7b\u6210\u5206ESI\u6a21\u5f0f\u4e0b\u5e38\u89c1\u7684\u88c2\u89e3\u89c4\u5f8b[16]<\/span><span style=\"font-size: 15px;text-align: justify;\">&nbsp;<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;vertical-align: top;height: 1.8em;width: 1.8em;border-radius: 50%;border-width: 3px;border-style: solid;border-color: rgb(240, 84, 84);font-size: 1.6em;text-align: center;color: rgb(240, 84, 84);background-color: rgb(254, 254, 254);transform: rotate(0deg);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u516d<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: -1.56em;margin-bottom: 1em;margin-left: 0.5em;max-width: 100%;border-radius: 1em;font-size: 1.2em;color: rgb(255, 255, 255);border-color: rgb(255, 140, 0);background-color: rgb(240, 84, 84);z-index: -1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 5px;margin-left: 5px;padding-right: 10px;padding-left: 2em;max-width: 100%;display: inline-block;vertical-align: top;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 1em;min-width: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b5b\u9009\u76ee\u6807\u6210\u5206\u7684\u9a8c\u8bc1<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u663e\u7136\uff0c\u63a5\u4e0b\u6765\u6211\u4eec\u9762\u4e34\u7684\u6311\u6218\u662f\u5bf9\u4e8e\u627e\u5230\u7684\u8fd9\u4e9b\u5dee\u5f02\u6210\u5206\u662f\u5426\u5177\u6709\u751f\u7269\u6d3b\u6027\u5462\uff1f\u662f\u5426\u80fd\u591f\u5177\u6709\u4ee3\u8868\u6027\uff1f\u4e3a\u6b64\uff0c\u6211\u4eec\u9700\u8981\u4e00\u65b9\u9762\u901a\u8fc7\u6587\u732e\u67e5\u8bc1\uff0c\u5bf9\u4f53\u5185\u5916\u53d1\u73b0\u7684\u5dee\u5f02\u6027\u6210\u5206\u7684\u751f\u7269\u6d3b\u6027\u8fdb\u884c\u8ffd\u8e2a\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u9700\u8981\u8fdb\u884c\u4e0d\u540c\u6279\u6b21\u6837\u54c1\u7ed9\u836f\u7684\u91cd\u590d\u9a8c\u8bc1\u5b9e\u9a8c\uff0c\u4e2a\u4eba\u63a8\u8350\u81f3\u5c11\u5f00\u5c55\u516d\u4e2a\u6279\u6b21\u6837\u54c1\u7ed9\u836f\u5b9e\u9a8c\uff0c\u4ee5\u8bc1\u660e\u53d1\u73b0\u7684\u542b\u91cf\u5dee\u5f02\u6027\u6807\u5fd7\u7269\u7684\u7a33\u5b9a\u6027\u548c\u53ef\u9760\u6027\u3002\u540c\u65f6\uff0c\u53ef\u4ee5\u91c7\u7528\u76f4\u63a5\u8d2d\u4e70\u76f8\u5e94\u7684\u6807\u51c6\u54c1\uff0c\u6216\u81ea\u5df1\u5206\u79bb\u5236\u5907\uff0c\u4ea6\u6216\u81ea\u5df1\u5408\u6210\u7b49\u9014\u5f84\u5f00\u5c55\u79bb\u4f53\u6d3b\u6027\u5b9e\u9a8c\u662f\u4e00\u79cd\u5f88\u597d\u7684\u9009\u62e9\uff0c\u6bd4\u5982\u5e38\u89c1\u7684LPS\u8bf1\u5bfc\u7684\u7ec6\u80de\u708e\u75c7\u6a21\u578b\uff0c\u80bf\u7624\u7ec6\u80de\u6291\u5236\u5b9e\u9a8c\u7b49\uff0c\u5e76\u7ed3\u5408Western Blot\uff0cELISA\u548cRT-PCR\u5b9e\u9a8c\u8fdb\u884c\u8868\u5f81\u3002\u6700\u540e\uff0c\u6240\u6709\u7684\u7ed3\u679c\u9700\u8981\u901a\u8fc7\u4f53\u5185\u5b9e\u9a8c\uff0c\u8fd0\u7528\u836f\u52a8\u5b66\uff08PK\uff09\u548c\u836f\u6548\u5b66\uff08PD\uff09\u76f8\u5173\u5b9e\u9a8c\u8fdb\u884c\u9a8c\u8bc1\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u6ce8\u610f\u4e8b\u9879\uff1a\u6240\u6709\u7684\u5b9e\u9a8c\u65b9\u6848\u5747\u9700\u8003\u8651\u7ed9\u836f\u5242\u91cf\u7684\u9009\u62e9\u3001\u53ca\u5176\u4e0e\u9633\u6027\u836f\u7684\u53ef\u6bd4\u6027\u3001\u5b9e\u9a8c\u5bf9\u7167\u7ec4\u8bbe\u5b9a\u7684\u5408\u7406\u6027\u548c\u836f\u7269\u6d53\u5ea6\u4f9d\u8d56\u6027\u7b49\u56e0\u7d20\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"padding: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;width: auto;height: 30px;line-height: 30px;display: -webkit-flex;justify-content: center;align-items: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 30px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"      style=\"display: block;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 30px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558315789.jpeg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/section>\n<section style=\"padding-right: 15px;padding-left: 15px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p class=\"\"><span style=\"color: rgb(214, 168, 65);\"><strong><span style=\"font-size: 16px;\">\u7ed3 \u675f \u8bed<\/span><\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;width: 30px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"      style=\"display: block;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 30px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558315789.png\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u5bf9\u4e8e\u4e00\u4e2a\u590d\u6742\u4f53\u7cfb\u6765\u8bf4\uff0c\u57fa\u4e8e\u7ec4\u5b66\u7684\u65b9\u6cd5\u4e0d\u5931\u4e3a\u4e00\u79cd\u8f83\u4e3a\u51c6\u786e\u548c\u7cbe\u786e\u7684\u65b9\u6cd5\u53bb\u9274\u522b\u4f53\u7cfb\u4e2d\u542b\u6709\u7684\u6d3b\u6027\u6210\u5206\u6216Biomarker\u3002\u91c7\u7528\u8be5\u65b9\u6cd5\u4e3b\u662f\u4ee5\u836f\u7269\u5728\u9776\u5668\u5b98\u6216\u4f53\u6db2\u4e2d\u7684\u542b\u91cf\u6216\u6d53\u5ea6\u5206\u5e03\u662f\u836f\u7269\u53d1\u6325\u836f\u6548\u4e3a\u524d\u63d0\u6761\u4ef6\u3002\u5f53\u7136\uff0c\u836f\u7269\u8d77\u6548\u7684\u9014\u5f84\u5e76\u4e0d\u5c40\u9650\u4e8e\u6b64\u3002\u4ee5\u4e2d\u836f\u7684\u591a\u7ec4\u5206\u4f53\u7cfb\u4e3a\u4f8b\uff0c\u5982\u738b\u5e7f\u57fa\u9662\u58eb\u63d0\u51fa\u7684\u201c\u8111\u75c5\u5916\u6cbb\u201d\u7684\u4f5c\u7528\u673a\u7406[20]\uff0c\u5176\u6307\u51fa\u4eba\u53c2\u7682\u82f7\u4e0d\u76f4\u63a5\u8fdb\u5165\u8111\u5185\u53d1\u6325\u4f5c\u7528\uff0c\u800c\u662f\u901a\u8fc7\u6291\u5236\u5916\u5468\u72ac\u5c3f\u6c28\u9178\u7684\u6c34\u5e73\uff0c\u51cf\u5c11\u8fdb\u5165\u8111\u5185\u7684\u72ac\u5c3f\u6c28\u9178\uff0c\u963b\u65ad\u5916\u5468\u708e\u75c7\u5411\u8111\u90e8\u7684\u4f20\u9012\uff0c\u53d1\u6325\u8111\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002<br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;\">\u8521\u5c11\u9752\u6559\u6388\u63d0\u51fa\u4e2d\u836f\u836f\u6548\u7269\u8d28\u7684\u201c\u663e\u6548\u5f62\u5f0f\u201d\u65b0\u6982\u5ff5\u53ca\u201c\u53e0\u52a0\u4f5c\u7528\u201d\u65b0\u5047\u8bf4[21]\uff1a\u4e2d\u836f\u836f\u6548\u7269\u8d28\u663e\u6548\u5f62\u5f0f\u7684\u96c6\u5408\u6216\u53e0\u52a0\u662f\u836f\u6548\u7684\u6838\u5fc3\u7269\u8d28\u57fa\u7840\uff0c\u5404\u4e2a\u663e\u6548\u5f62\u5f0f\u7684\u8840\u836f\u6d53\u5ea6\u7684\u53e0\u52a0\u4f5c\u7528\u662f\u836f\u6548\u4f5c\u7528\u673a\u5236\u4e4b\u4e00\u3002\u8be5\u65b9\u6cd5\u80fd\u591f\u8f83\u4e3a\u5b8c\u6574\u5730\u5448\u73b0\u4f53\u5916\u590d\u6742\u4f53\u7cfb\u4e2d\u5316\u5b66\u6210\u5206\u7684\u8f6e\u5ed3\uff0c\u540c\u65f6\u53c8\u80fd\u591f\u8f83\u597d\u5730\u53d1\u73b0\u5316\u5b66\u6210\u5206\u7684\u5438\u6536\u3001\u5206\u5e03\u548c\u4ee3\u8c22\u5dee\u5f02\u3002\u53c8\u5982\u5218\u660c\u5b5d\u9662\u58eb\u63d0\u51fa\u7684\u4e2d\u836f\u8d28\u91cf\u6807\u5fd7\u7269\uff08Q-Markers\uff09\u7684\u65b0\u6982\u5ff5[22]\uff0c\u57fa\u4e8e\u6b64\u6211\u4eec\u53ef\u4ee5\u5c1d\u8bd5\u7531\u4f53\u5185\u4ee3\u8868\u6027\u5dee\u5f02\u6210\u5206\u53bb\u5efa\u7acb\u5bf9\u4f53\u5916\u836f\u6750\u7684\u8d28\u91cf\u8bc4\u4ef7\u548c\u63a7\u5236\u7684\u8d28\u91cf\u6210\u5206\u7fa4\uff0c\u62df\u4e3a\u4e2d\u836f\u7269\u8d28\u57fa\u7840\u7684\u7814\u7a76\u63d0\u4f9b\u6570\u636e\u652f\u6301\u3002<\/span><\/p>\n<p><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 16px;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[1].&nbsp;\u6731\u8d85;&nbsp;\u80e1\u576a;&nbsp;\u6881\u743c\u9e9f;&nbsp;\u738b\u4e49\u660e;&nbsp;\u7f57\u56fd\u5b89,&nbsp;\u4ee3\u8c22\u7ec4\u5b66\u6280\u672f\u7684\u6574\u5408\u8fd0\u7528\u53ca\u5176\u5728\u4e2d\u836f\u73b0\u4ee3\u5316\u4e2d\u7684\u5e94\u7528\u5c55\u671b.&nbsp;\u4e2d\u56fd\u5b66\u672f\u671f\u520a\u6587\u6458&nbsp;[J].&nbsp;2008, 14, 9-9.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[2]. Daykin, C. A.; Wulfert, F., NMR spectroscopy based metabonomics: current technology and applications.&nbsp;Frontiers in Drug Design &amp; Discovery [J].&nbsp;2006, 2, 151-173.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[3]. Dettmer, K.; Aronov, P. A.; Hammock, B. D., Mass spectrometry\u2010based metabolomics.&nbsp;Mass Spectrom. Rev. [J].&nbsp;2007, 26, 51-78.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[4]. Bletsou, A. A.; Jeon, J.; Hollender, J.; Archontaki, E.; Thomaidis, N. S., Targeted and non-targeted liquid chromatography-mass spectrometric workflows for identification of transformation products of emerging pollutants in the aquatic environment.TrAC Trends in Analytical Chemistry [J].&nbsp;2015, 66, 32-44.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[5].&nbsp;\u6797\u5fc5\u6842;&nbsp;\u4e8e\u4e91\u6c5f;&nbsp;\u5411\u660e\u706f;&nbsp;\u4f59\u4e50\u6d39;&nbsp;\u674e\u826f\u5fe0;&nbsp;\u97a0\u52c7\u660e;&nbsp;\u7389\u7433,&nbsp;\u57fa\u4e8e\u6c14\u76f8\/\u6db2\u76f8\u8272\u8c31-\u9ad8\u5206\u8fa8\u7387\u8d28\u8c31\u8054\u7528\u6280\u672f\u7684\u975e\u76ee\u6807\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\u7814\u7a76\u8fdb\u5c55.&nbsp;\u73af\u5883\u5316\u5b66&nbsp;[J].&nbsp;2016, 466-476.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[6]. Pluskal, T.; Castillo, S.; Villar-Briones, A.; Ore\u0161i\u010d, M., MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data.&nbsp;BMC bioinformatics [J].&nbsp;2010, 11, 1.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[7]. Katajamaa, M.; Miettinen, J.; Ore\u0161i\u010d, M., MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data.&nbsp;Bioinformatics [J].&nbsp;2006, 22, 634-636.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[8]. Smith, C. A.; Want, E. J.; O&#8217;Maille, G.; Abagyan, R.; Siuzdak, G., XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.&nbsp;Analytical chemistry [J].&nbsp;2006, 78, 779-787.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[9]. Tautenhahn, R.; Patti, G. J.; Rinehart, D.; Siuzdak, G., XCMS Online: a web-based platform to process untargeted metabolomic data.&nbsp;Analytical chemistry [J].&nbsp;2012, 84, 5035-5039.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[10]. Gowda, H.; Ivanisevic, J.; Johnson, C. H.; Kurczy, M. E.; Benton, H. P.; Rinehart, D.; Nguyen, T.; Ray, J.; Kuehl, J.; Arevalo, B., Interactive XCMS Online: simplifying advanced metabolomic data processing and subsequent statistical analyses.&nbsp;Analytical chemistry [J].&nbsp;2014, 86, 6931-6939.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[11]. Duran, A. L.; Yang, J.; Wang, L.; Sumner, L. W., Metabolomics spectral formatting, alignment and conversion tools (MSFACTs).&nbsp;Bioinformatics [J].&nbsp;2003, 19, 2283-2293.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[12]. Lommen, A., MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing.&nbsp;Analytical chemistry [J].&nbsp;2009, 81, 3079-3086.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[13].&nbsp;\u963f\u57fa\u4e1a,&nbsp;\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u5904\u7406\u65b9\u6cd5\u2014\u2014\u4e3b\u6210\u5206\u5206\u6790.&nbsp;\u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u4e0e\u6cbb\u7597\u5b66&nbsp;[J].&nbsp;2010, 481-489.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[14].&nbsp;\u67ef\u671d\u752b;&nbsp;\u5f20\u6d9b;&nbsp;\u6b66\u6653\u5ca9;&nbsp;\u674e\u5eb7,&nbsp;\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u5206\u6790\u7684\u7edf\u8ba1\u5b66\u65b9\u6cd5.&nbsp;\u4e2d\u56fd\u536b\u751f\u7edf\u8ba1&nbsp;[J].&nbsp;2014, 31, 357-359.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[15].&nbsp;\u5362\u7ea2\u6885;&nbsp;\u6881\u9038\u66fe,&nbsp;\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u6280\u672f\u53ca\u6570\u636e\u5904\u7406\u6280\u672f.&nbsp;\u5206\u6790\u6d4b\u8bd5\u5b66\u62a5&nbsp;[J].&nbsp;2008, 27, 325-332.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[16]. Yang, Z. W.; Xu, F.; Liu, X.; Cao, Y.; Tang, Q.; Chen, Q. Y.; Shang, M. Y.; Liu, G. X.; Wang, X.; Cai, S. Q., An untargeted metabolomics approach to determine component differences and variation in their in vivo distribution between Kuqin and Ziqin, two commercial specifications of Scutellaria Radix.&nbsp;Rsc Advances [J].&nbsp;2017, 7, 54682-54695.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[17].&nbsp;\u7533\u56fd\u5b89;&nbsp;\u6bb5\u793c\u65b0;&nbsp;\u6f06\u5c0f\u6cc9,&nbsp;\u690d\u7269\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u5206\u6790\u548c\u6570\u636e\u5e93.&nbsp;\u751f\u547d\u79d1\u5b66&nbsp;[J].&nbsp;2015, 995-999.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[18].&nbsp;\u5468\u56fd\u8273;&nbsp;\u80e1\u671b\u96c4;&nbsp;\u5f90\u5efa\u7ea2;&nbsp;\u859b\u5e86\u4e2d,&nbsp;\u6574\u5408\u591a\u4e2a\u7ec4\u5b66(omics)\u5206\u6790\u690d\u7269\u4ee3\u8c22\u4ea7\u7269\u53ca\u5176\u529f\u80fd.&nbsp;\u6d59\u6c5f\u5927\u5b66\u5b66\u62a5(\u519c\u4e1a\u4e0e\u751f\u547d\u79d1\u5b66\u7248) [J].&nbsp;2013, 237-245.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[19].&nbsp;\u738b\u52c7\u4e3a,&nbsp;\u786e\u8bc1\u5b9a\u91cf\u5206\u6790\u65b0\u5de5\u5177\u2014\u2014Thermo Scientific Q Exactive\u53f0\u5f0f\u56db\u6781\u6746-\u8f68\u9053\u9631\u9ad8\u5206\u8fa8\u8d28\u8c31\u4eea.&nbsp;\u73b0\u4ee3\u79d1\u5b66\u4eea\u5668&nbsp;[J].&nbsp;2011, 138-140.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[20]. Zheng, X.; Zhang, X.; Kang, A.; Ran, C.; Wang, G.; Hao, H., Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?&nbsp;Neuropharmacology [J].&nbsp;2015, 96, Part A, 94-104.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[21].&nbsp;\u5f90\u98ce;&nbsp;\u6768\u4e1c\u8f89;&nbsp;\u5c1a\u660e\u82f1;&nbsp;\u738b\u7487;&nbsp;\u8521\u5c11\u9752,&nbsp;\u4e2d\u836f\u836f\u6548\u7269\u8d28\u7684\u201c\u663e\u6548\u5f62\u5f0f\u201d\u3001\u201c\u53e0\u52a0\u4f5c\u7528\u201d\u548c\u201c\u6bd2\u6027\u5206\u6563\u6548\u5e94\u201d\u2014\u2014\u7531\u4e2d\u836f\u4f53\u5185\u4ee3\u8c22\u7814\u7a76\u5f15\u53d1\u7684\u601d\u8003.&nbsp;\u4e16\u754c\u79d1\u5b66\u6280\u672f-\u4e2d\u533b\u836f\u73b0\u4ee3\u5316&nbsp;[J].&nbsp;2014, 688-703.<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\">[22].&nbsp;\u5218\u660c\u5b5d;&nbsp;\u9648\u58eb\u6797;&nbsp;\u8096\u5c0f\u6cb3;&nbsp;\u5f20\u94c1\u519b;&nbsp;\u4faf\u6587\u5f6c;&nbsp;\u5ed6\u8302\u6881,&nbsp;\u4e2d\u836f\u8d28\u91cf\u6807\u5fd7\u7269(Q-Marker):\u4e2d\u836f\u4ea7\u54c1\u8d28\u91cf\u63a7\u5236\u7684\u65b0\u6982\u5ff5.&nbsp;\u4e2d\u8349\u836f&nbsp;[J].&nbsp;2016, 1443-1457.<\/span><\/p>\n<p><br  \/><\/p>\n<h2 class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;font-size: 22px;white-space: normal;max-width: 100%;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.4;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(255, 127, 170);\"><strong><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247501032&amp;idx=2&amp;sn=0f6700af84ae8f3aa7df6da6811b0519&amp;chksm=ecaa8a1fdbdd03098fcf9b33f0777e10097ad6fad009fb8befe41da103c37668ce6e3dac0560&amp;mpshare=1&amp;scene=21&amp;srcid=&amp;pass_ticket=cLD9hndLTIy79YwTwMvVrUKoaWTLWUT4c9doEKGoSYB9fkrx3nGRx585ELIKAu6L#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5f81\u7a3f\u542f\u4e8b<\/a><\/span><\/strong><\/span><\/h2>\n<section style=\"white-space: normal;max-width: 677px;box-sizing: border-box;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 3px;margin-left: 3px;padding: 20px;max-width: 677px;box-sizing: border-box;background-color: rgb(254, 254, 254);border-color: rgb(210, 150, 20);box-shadow: rgb(210, 150, 20) 0px 0px 4px;overflow-wrap: break-word !important;\">\n<h2 class=\"\" style=\"margin-bottom: 14px;font-size: 22px;max-width: 100%;line-height: 1.4;font-variant-numeric: normal;letter-spacing: 0.544px;text-align: start;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5NDk0NTc4MQ==&amp;mid=2650426044&amp;idx=1&amp;sn=c87b281bb6b7baade0105eb459c19ba9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 14px;color: rgb(61, 167, 66);box-sizing: border-box !important;overflow-wrap: break-word !important;\">2019\u836f\u7269\u5206\u79bb\u7eaf\u5316\u548c\u7ed3\u6784\u9274\u5b9a\u53ca\u8d4b\u503c\u6df1\u5ea6\u7814\u8ba8\u4f1a &#8211;CMC\u836f\u7269\u8d28\u91cf\u7cfb\u5217\u7814\u8ba8\u4f1a\u4e4b\u4e09<\/span><\/a><\/h2>\n<p style=\"max-width: 631px;box-sizing: border-box;min-height: 18px;color: rgb(210, 150, 20);font-weight: 700;min-width: 1px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.54px;color: rgb(51, 51, 51);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(214, 168, 65);overflow-wrap: break-word !important;\">\u540c\u5199\u610f\u8bba\u575b\uff1a<\/span><\/strong><\/p>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 631px;box-sizing: border-box;border-color: rgb(210, 150, 20);overflow-wrap: break-word !important;\">\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628137&amp;idx=1&amp;sn=31a673ec733f84c6eee6873b1fe626c8&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5199\u610f\u5de8\u732e\uff1a\u6df1\u5ea6\u89e3\u6790\u4e2d\u7f8e\u52a0\u5feb\u836f\u54c1\u7814\u53d1\u7684\u5ba1\u8bc4\u5ba1\u6279\u653f\u7b56\uff0891\u671f\u65e5\u7a0b\u66f4\u65b0\uff09<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650627699&amp;idx=1&amp;sn=cb1df4a9fd9b4bb1582c9f94d3520f73&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c93\u671f\u8bba\u575b\u4e282019\u4e2d\u7f8e\u533b\u7597\u6295\u8d44\u8bba\u575b\u548c\u8def\u6f14<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628250&amp;idx=2&amp;sn=bbf58c464d6eb350985cf5cf6354af1c&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u540c\u5199\u610f\u534f\u529e\u4e282019\u7ec6\u80de\u6cbb\u7597\u4ea7\u4e1a\u53d1\u5c55\u6e56\u5317\u5cf0\u4f1a\uff08free\uff09<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">4.<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628019&amp;idx=1&amp;sn=5dae65d812e02cc8e74e2a352bbba5d6&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;letter-spacing: 0.54px;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c94\u671f\u8bba\u575b\u4e28\u4eff\u5236\u836f\u9009\u9898\u7acb\u9879\u2014\u7b56\u7565\u4e0e\u65b9\u6cd5<\/span><\/a><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">5.<span style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650628093&amp;idx=1&amp;sn=ce26e32435f63b4eb8b913c510cfb31f&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c95\u671f\u8bba\u575b\u4e28BD\u4e2d\u7ea7\u73ed\uff1a\u521b\u65b0\u53d1\u9879\u76ee\u7684\u7efc\u5408\u8bc4\u4f30<\/a><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzU2MDY5MzA0OQ==&amp;mid=2247484428&amp;idx=1&amp;sn=d7540b3b4d54422e4996085f2bbc0079&amp;chksm=fc056e5acb72e74cec1843e4eb3f9cf04dcf6ea93b9d8448da418734b13b6440111ca014de9a&amp;token=1732418045&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages __bg_gif\"          style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 556px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558315790.gif\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><\/span><\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;box-sizing: border-box;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><img class=\"\"        width=\"676.997px\"  style=\"box-sizing: border-box;font-size: 15px;letter-spacing: 0.54px;text-align: center;overflow-wrap: break-word !important;visibility: visible !important;width: 676.997px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558315790.jpg\" alt=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\" title=\"\u590d\u6742\u4f53\u7cfb\u4e2d\u6d3b\u6027\u6210\u5206\u7684\u9274\u522b\u53ca\u9a8c\u8bc1\u7b56\u7565\"  \/><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;background-color: rgb(255, 255, 255);letter-spacing: 0.582857px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u7531\u4ee5\u4e0b\u6210\u5458\u7ec4\u6210\uff1aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cSophia \uff0c\u5076\u9635\u96e8\uff0c\u96f6\u4e0b274\u2103\uff0cHelen\uff0cZMJ\uff0c\u6da6\u513f\uff0c\u7f8a\u7f8a\u3001<span style=\"max-width: 100%;letter-spacing: 0.582857px;box-sizing: border-box 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!important;\">\u8d23\u4efb\u7f16\u8f91\uff1a\u96f7\u8bfa\u5c9b<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981 \u57fa\u4e8e\u4ee3\u8c22\u7ec4\u5b66\u65b9\u6cd5\u80fd\u8f83\u4e3a\u76f4\u89c2\u548c\u5b8c\u6574\u5730\u5448\u73b0\u4f53\u5916\u590d\u6742\u4f53\u7cfb\u4e2d\u5316\u5b66\u6210\u5206\u7684\u8f6e\u5ed3\u5dee\u5f02\u53ca\u5176\u5728\u4f53\u5185\u5438\u6536\u3001\u5206\u5e03\u548c\u4ee3\u8c22\u7684\u5dee\u5f02\u3002 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