{"id":112334,"date":"2019-05-22T00:00:50","date_gmt":"2019-05-22T07:42:29","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/112334\/"},"modified":"2019-05-22T15:42:31","modified_gmt":"2019-05-22T07:42:31","slug":"cf6998361f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/112334\/","title":{"rendered":"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1  style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4eca\u65e5\uff0c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u548cPeloton Therapeutics\u516c\u53f8\u8054\u5408\u5ba3\u5e03\uff0c\u53cc\u65b9\u8fbe\u6210\u534f\u8bae\uff0c\u9ed8\u6c99\u4e1c\u5c06\u901a\u8fc7\u5176\u5b50\u516c\u53f8\u6536\u8d2dPeloton\u516c\u53f8\u3002Peloton\u516c\u53f8\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u5f00\u53d1\u9776\u5411\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50-2\u03b1\uff08HIF-2\u03b1\uff09\u7684\u521b\u65b0\u5c0f\u5206\u5b50\u7597\u6cd5\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u533b\u836f\u516c\u53f8\u3002<strong>\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u5019\u9009\u836f\u7269PT2977\uff0c\u662f\u4e00\u6b3e\u521b\u65b0\u53e3\u670dHIF-2\u03b1\u6291\u5236\u5242<\/strong>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558510950.jpg\" alt=\"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f\" title=\"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">HIF-2\u03b1\u662f\u4e00\u79cd\u8c03\u8282\u673a\u4f53\u5bf9\u7f3a\u6c27\u73af\u5883\u53cd\u5e94\u7684\u8f6c\u5f55\u56e0\u5b50\u3002\u5b83\u53ef\u4ee5\u8c03\u8282\u591a\u79cd\u86cb\u767d\u8868\u8fbe\uff0c\u4fc3\u8fdb\u8840\u7ea2\u7ec6\u80de\u548c\u65b0\u8840\u7ba1\u7684\u751f\u6210\u3002\u5728\u67d0\u4e9b\u75be\u75c5\u4e2d\uff0cHIF-2\u03b1\u4fe1\u53f7\u901a\u8def\u53ef\u80fd\u51fa\u73b0\u5f02\u5e38\uff0c\u4f8b\u5982\u5728\u5927\u90e8\u5206\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u4e2d\uff0c<em>VHL<\/em>\u6291\u764c\u57fa\u56e0\u7684\u5931\u6d3b\u4f1a\u5bfc\u81f4HIF-2\u03b1\u7684\u5f02\u5e38\u6fc0\u6d3b\uff0c\u6210\u4e3a\u9a71\u52a8RCC\u7684\u5173\u952e\u56e0\u5b50\u3002<strong><em>VHL<\/em>\u6291\u764c\u57fa\u56e0\u7684\u5931\u6d3b\u51fa\u73b0\u5728\u8d85\u8fc790%\u7684\u900f\u660e\u7ec6\u80deRCC\u60a3\u8005\u4e2d\uff0c\u800c\u900f\u660e\u7ec6\u80deRCC\u662f\u6700\u5e38\u89c1\u7684\u80be\u764c\u7c7b\u578b<\/strong>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Peoloton\u516c\u53f8\u7684\u4e3b\u6253\u5019\u9009\u836f\u7269PT2977\uff0c\u662f\u4e00\u6b3e\u7279\u5f02\u6027\u3001\u5f3a\u529b\u53e3\u670dHIF-2\u03b1\u6291\u5236\u5242\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u5b83\u76ee\u524d\u57282\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7528\u4e8e\u6cbb\u7597\u4e0e<em>VHL<\/em>\u76f8\u5173\u7684RCC\u60a3\u8005\u3002PT2977\u76841\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u5b83\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5e76\u4e14\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u5728\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027RCC\u60a3\u8005\u65f6\uff0c\u8868\u73b0\u51fa\u53ef\u559c\u7684\u6297\u764c\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558510950.jpg\" alt=\"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f\" title=\"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<h1  style=\"text-align: center;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 14px;\">\u25b2PT2977\u4f5c\u7528\u673a\u5236\uff08\u56fe\u7247\u6765\u6e90\uff1aPeloton\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/span><\/h1>\n<p style=\"line-height: 1.75em;\"><strong style=\"white-space: normal;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u534f\u8bae\uff0c\u9ed8\u6c99\u4e1c\u5c06\u652f\u4ed810.5\u4ebf\u7f8e\u5143\u524d\u671f\u4ed8\u6b3e\uff0c\u800c\u4e14\u6839\u636e\u672a\u6765\u7684\u76d1\u7ba1\u548c\u63a8\u5e7f\u91cc\u7a0b\u7891\uff0cPeloton\u516c\u53f8\u53ef\u80fd\u83b7\u5f9711.5\u4ebf\u7f8e\u5143\u7684\u540e\u7eed\u4ed8\u6b3e\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201cPeloton\u7684\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u4ed6\u4eec\u5bf9HIF-2\u03b1\u751f\u7269\u5b66\u7684\u4e13\u957f\u5f00\u53d1\u51faPT2977\uff0c\u5b83\u5df2\u7ecf\u5728\u6cbb\u7597RCC\u65b9\u9762\u663e\u793a\u51fa\u503c\u5f97\u5173\u6ce8\u7684\u6d3b\u6027\uff0c\u201d\u9ed8\u6c99\u4e1c\u7814\u7a76\u5b9e\u9a8c\u5ba4\u603b\u88c1Roger M. Perlmutter\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u671f\u5f85\u63a8\u52a8\u8fd9\u6b3e\u4e34\u5e8a\u540e\u671f\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\uff0c\u5c06\u5b83\u7eb3\u5165\u6211\u4eec\u7684\u80bf\u7624\u5b66\u7814\u53d1\u9879\u76ee\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u9ed8\u6c99\u4e1c\u516c\u53f8\u662f\u764c\u75c7\u7814\u7a76\u65b9\u9762\u7684\u9886\u5148\u516c\u53f8\u4e4b\u4e00\uff0c\u5b83\u4e0e\u6211\u4eec\u5171\u540c\u62e5\u6709\u52a0\u5feb\u9776\u5411HIF-2\u03b1\u7597\u6cd5\u7684\u5f00\u53d1\uff0c\u5e2e\u52a9\u665a\u671f\u764c\u75c7\u548c\u5176\u5b83\u75be\u75c5\u60a3\u8005\u7684\u613f\u666f\uff0c\u201dPeloton\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98John A. Josey\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u76f8\u4fe1\u9ed8\u6c99\u4e1c\u80fd\u591f\u57fa\u4e8e\u6211\u4eec\u7684\u7814\u53d1\u8fdb\u5c55\uff0c\u7ee7\u7eed\u63a8\u52a8\u8fd9\u4e00\u9879\u76ee\u7684\u5f00\u53d1\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Merck to Acquire Peloton Therapeutics, Bolstering Oncology Pipeline. Retrieved May 21, 2019, from https:\/\/www.businesswire.com\/news\/home\/20190521005432\/en\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Peloton Therapeutics. Retrieved May 21, 2019, from https:\/\/www.pelotontherapeutics.com\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"__bg_gif\"      style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558510951.gif\" alt=\"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f\" title=\"\u901f\u9012 | 22\u4ebf\u7f8e\u5143\u6536\u8d2d\uff01\u9ed8\u6c99\u4e1c\u56ca\u83b7\u80be\u7ec6\u80de\u764c\u5019\u9009\u65b0\u836f\"  \/><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u65e5\uff0c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u548cPeloton Therapeutics\u516c\u53f8\u8054\u5408\u5ba3\u5e03\uff0c\u53cc\u65b9\u8fbe\u6210\u534f\u8bae\uff0c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":112335,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/112334"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=112334"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/112334\/revisions"}],"predecessor-version":[{"id":112339,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/112334\/revisions\/112339"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/112335"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=112334"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=112334"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=112334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}