{"id":112340,"date":"2019-05-22T00:00:50","date_gmt":"2019-05-22T07:42:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/112340\/"},"modified":"2019-05-22T15:42:34","modified_gmt":"2019-05-22T07:42:34","slug":"4ce520f9f0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/112340\/","title":{"rendered":"\u901f\u9012 | \u663e\u8457\u7f13\u89e3\u60a3\u8005\u80ba\u529f\u80fd\u4e0b\u964d\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u65b0\u836f\u4eca\u5e74\u6709\u671b\u4e0a\u5e02"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/h1>\n

\u65e5\u524d\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\uff08Boehringer Ingelheim\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u5f00\u53d1\u7684nintedanib\uff0c\u5728\u6cbb\u7597\u7cfb\u7edf\u6027\u786c\u5316\u75c5\u76f8\u5173\u95f4\u8d28\u6027\u80ba\u75be\u75c5\uff08SSc-ILD\uff09\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8fbe\u5230\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u663e\u8457\u5ef6\u7f13\u60a3\u8005\u80ba\u529f\u80fd\u7684\u4e27\u5931\u901f\u5ea6\u3002\u8fd9\u4e9b\u6570\u636e\u540c\u65f6\u53d1\u5e03\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM<\/em>\uff09\u4e0a\u3002Nintedanib\u6cbb\u7597SSc-ILD\u7684\u76d1\u7ba1\u7533\u8bf7\u5df2\u7ecf\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff0c\u6709\u671b\u5728\u4eca\u5e74\u83b7\u6279\u4e0a\u5e02<\/strong>\u3002<\/span><\/p>\n


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\u7cfb\u7edf\u6027\u786c\u5316\u75c5\u53c8\u79f0\u4e3a\u786c\u76ae\u75c5 (scleroderma) \uff0c\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u5bfc\u81f4\u4eba\u4f53\u5185\u591a\u4e2a\u5668\u5b98\u4e2d\u7684\u7ed3\u7f14\u7ec4\u7ec7\u51fa\u73b0\u786c\u5316\u548c\u75a4\u75d5\u7ec4\u7ec7\u7684\u75be\u75c5\u3002\u5927\u591a\u6570\u60a3\u8005\u4f1a\u5728\u80ba\u90e8\u4ea7\u751f\u4e00\u5b9a\u7a0b\u5ea6\u7684\u80ba\u90e8\u75a4\u75d5\u7ec4\u7ec7\uff0c\u5373\u95f4\u8d28\u6027\u80ba\u75be\u75c5\u3002\u8fd9\u901a\u5e38\u662f\u7cfb\u7edf\u6027\u786c\u5316\u75c5\u60a3\u8005\u6b7b\u4ea1\u7684\u9996\u8981\u539f\u56e0\u3002\u76ee\u524d\u8fd8\u6ca1\u6709\u4efb\u4f55FDA\u6279\u51c6\u7684\u836f\u7269\u80fd\u591f\u6cbb\u7597\u8fd9\u4e00\u75be\u75c5\uff0c\u800c\u4e14\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u68c0\u9a8c\u7684\u5728\u7814\u836f\u7269\u4e5f\u975e\u5e38\u7a00\u5c11\u3002<\/strong><\/span><\/p>\n


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Nintedanib\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u5f00\u53d1\u7684\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5b83\u5df2\u7ecf\u83b7\u5f97\u6279\u51c6\u6cbb\u7597\u79f0\u4e3a\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316 (idiopathic pulmonary fibrosis\uff0c IPF) \u7684\u7f55\u89c1\u80ba\u90e8\u75be\u75c5\u3002Nintedanib\u80fd\u591f\u6291\u5236PDGF\uff0c FGF\uff0cVEGF\u7b49\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6d3b\u6027\u3002\u8fd9\u4e9b\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u88ab\u8ba4\u4e3a\u5a92\u4ecbIPF\u7684\u75c5\u7406\u8fc7\u7a0b\u3002Nintedanib\u80fd\u591f\u6709\u6548\u964d\u4f4eIPF\u60a3\u8005\u6bcf\u5e74\u80ba\u529f\u80fd\u4e0b\u964d\u7684\u901f\u5ea6\u3002\u56e0\u4e3aSSc-ILD\u548cIPF\u4e4b\u95f4\u5728\u80ba\u90e8\u75a4\u75d5\u7ec4\u7ec7\u6216\u7ea4\u7ef4\u5316\u5f62\u6210\u7684\u65b9\u5f0f\u4e0a\u6709\u76f8\u4f3c\u4e4b\u5904\uff0c\u56e0\u6b64\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u51b3\u5b9a\u68c0\u6d4bnintedanib\u5728\u6cbb\u7597SSc-ILD\u65b9\u9762\u7684\u7597\u6548\u3002<\/span><\/p>\n


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\u25b2Nintedanib\u7684\u5206\u5b50\u7ed3\u6784\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aBy Ed (Edgar181) (Own work) [Public domain], via Wikimedia Commons\uff09<\/span><\/strong><\/p>\n


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\u5728\u540d\u4e3aSENSCIS\u7684\u968f\u673a\u53cc\u76f2\uff0c\u542b\u5b89\u6170\u5242\u5bf9\u7167\u7684\uff13\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c576\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u5b89\u6170\u5242\u6216nintedanib\u7684\u6cbb\u7597\u3002\u5728\u63a5\u53d7\u6cbb\u759752\u5468\u4e4b\u540e\uff0cnintedanib\u7ec4\u60a3\u8005\u7684\u7528\u529b\u80ba\u6d3b\u91cf\uff08forced vital capacity, FVC\uff09\u4e0b\u964d\u901f\u5ea6\u4e3a52.4\u6beb\u5347\/\u5e74\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u6570\u503c\u4e3a93.3\u6beb\u5347\/\u5e74\uff08p=0.04\uff09\u3002\u8fd9\u610f\u5473\u7740nintedanib\u5c06\u60a3\u8005\u80ba\u529f\u80fd\u4e0b\u964d\u901f\u5ea6\u51cf\u5c11\u4e8644%<\/strong>\u3002<\/span><\/p>\n


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\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u516c\u5e03\u5173\u952e\u60273\u671f\u4e34\u5e8a\u8bd5\u9a8cSENSCIS\u7684\u79ef\u6781\u7ed3\u679c\u3002\u8fd9\u4e9b\u7ed3\u679c\u662f\u6211\u4eec\u5411FDA\u548cEMA\u9012\u4ea4\u76d1\u7ba1\u7533\u8bf7\u7684\u57fa\u7840\uff0c\u201d \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u547c\u5438\u7cfb\u7edf\u533b\u836f\u8d1f\u8d23\u4ebaSusanne Stowasser\u535a\u58eb\u8bf4\uff1a\u201c\u5305\u62ecSSc-ILD\u5728\u5185\u7684\u7ea4\u7ef4\u5316\u80ba\u75c5\u5bf9\u60a3\u8005\u7684\u751f\u6d3b\u4ea7\u751f\u707e\u96be\u6027\u5f71\u54cd\u3002\u6211\u4eec\u5c06\u81f4\u529b\u4e8e\u6539\u5584\u8fd9\u4e9b\u5177\u6709\u9ad8\u5ea6\u672a\u7adf\u9700\u6c42\u7684\u60a3\u8005\u7684\u751f\u6d3b\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Phase III study showed nintedanib slows the loss of pulmonary function in people living with systemic sclerosis associated ILD1. Retrieved May 21, 2019, from https:\/\/www.boehringer-ingelheim.com\/press-release\/nintedanib-slows-pulmonary-function-loss-in-people-with-ssc-ild?<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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