{"id":112368,"date":"2019-05-22T00:00:50","date_gmt":"2019-05-22T07:42:43","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/112368\/"},"modified":"2019-05-22T15:42:45","modified_gmt":"2019-05-22T07:42:45","slug":"fc07dda61e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/112368\/","title":{"rendered":"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 2em;\"><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">2019\u5e745\u67089\u65e5\uff0cFibroGen\u548c\u963f\u65af\u5229\u5eb7\u5206\u522b\u5728\u5b98\u7f51\u53d1\u5e03\u6d88\u606f\uff0c\u516c\u5e03\u4e86\u7f57\u6c99\u53f8\u4ed6\u5168\u7403\u591a\u4e2aIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7684<strong>\u6c47\u603b\u5206\u6790<\/strong>\uff08<\/span><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">pooled analysis<\/span><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u53c8\u79f0\u6574\u5408\u5f0f\u5206\u6790\uff09\u7684\u79ef\u6781\u7ed3\u679c\u3002<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 2em;\"><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 2em;\"><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f46\u662f\u8fd9\u4e2a\u79ef\u6781\u7ed3\u679c\u516c\u5e03\u540e\uff0cFibroGen\u7684\u80a1\u4ef7\u53cd\u800c\u4e0b\u8dcc\u4e86\u4e0d\u5c11\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u56e0\u4e3a\u6b64\u524d\u90e8\u5206\u6295\u8d44\u4eba\u5bf9\u8be5\u7ed3\u679c\u9884\u671f\u8f83\u9ad8\uff0c\u4f46\u6b64\u6b21\u516c\u5e03\u7684\u7ed3\u679c\u4f3c\u4e4e\u5b58\u5728\u4e0d\u786e\u5b9a\u6027\u3002\u76ee\u524d\uff0cFibroGen\u6b63\u5c31\u8be5\u7ed3\u679c\u4e0e\u7f8e\u56fd\u836f\u54c1\u7ba1\u7406\u5c40\uff08FDA<span style=\"font-size: 14px;letter-spacing: 2px;background-color: rgb(255, 255, 255);\">\uff09<\/span>\u8fdb\u884c\u6c9f\u901a\uff0c\u5c1a\u5f85\u8fdb\u4e00\u6b65\u516c\u5e03\u8fdb<\/span><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5c55\u3002<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 2em;\"><br  \/><span style=\"font-size: 14px;letter-spacing: 2px;\"><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f57\u6c99\u53f8\u4ed6\u662f<span style=\"font-size: 14px;letter-spacing: 2px;\">FibroGen<\/span>\u4f18\u5148\u4e3a\u4e2d\u56fd\u60a3\u8005\u6253\u9020\u7684\u4e00\u6b3efirst in class\u65b0\u836f\uff0c\u9886\u5148\u5176\u4ed6\u56fd\u5bb6\u7387\u5148\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u5907\u53d7\u884c\u4e1a\u5173\u6ce8\u3002\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA<span style=\"font-size: 14px;letter-spacing: 2px;background-color: rgb(255, 255, 255);\">\uff09<\/span>\u80fd\u591f\u9886\u5148\u6b27\u7f8e\u505a\u51fa\u6279\u51c6\uff0c\u5c31\u8bf4<\/span><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u660e\u7f57\u6c99\u53f8\u4ed6\u7684\u4e34\u5e8a\u98ce\u9669-\u83b7\u76ca\u662f\u53ef\u4ee5\u63a5\u53d7\u7684\uff0c\u90a3\u4e48\u6211\u4eec\u8be5\u5982\u4f55\u770b\u5f85\u7f57\u6c99\u53f8\u4ed6<span style=\"font-size: 14px;letter-spacing: 2px;background-color: rgb(255, 255, 255);\">\u6b64\u6b21<\/span>\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\uff1f\u7f57\u6c99\u53f8\u4ed6\u5728\u6b27\u7f8e\u83b7\u6279\u4e0a\u5e02\u7684\u524d\u666f\u5982\u4f55\uff0c\u80fd\u5426\u5982\u671f\u83b7\u6279\uff1f\u6211\u4eec\u4eca\u5929\u57fa\u4e8epooled analysis\u7684\u7ed3\u679c\u518d\u8fdb\u4e00\u6b65\u6df1\u5165\u5206\u6790\u4e00\u4e0b\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e3a\u4e86\u65b9\u4fbf\u5927\u5bb6\u7406\u89e3\u540e\u9762\u7684\u4fe1\u606f\uff0c\u9700\u8981\u5148\u89e3\u91ca\u4e00\u4e0b<span style=\"font-size: 14px;letter-spacing: 2px;background-color: rgb(255, 255, 255);\">FibroGen\u6b64\u6b21\u4e3a\u4e86\u8bc4\u4f30\u7f57\u6c99\u53f8\u4ed6<\/span>\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u800c\u91c7\u7528\u7684\u4e24\u4e2a\u4e3b\u8981\u7ec8\u70b9\uff1a1\uff09<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">MACE\uff0c\u662f\u6307\u5168\u56e0\u6b7b\u4ea1\u3001\u5352\u4e2d\u548c\u5fc3\u808c\u6897\u6b7b\u4e8b\u4ef6\u7684\u590d\u5408\u7ec8\u70b9\uff0c\u662fFDA\u8ba4\u53ef\u7684\u5173\u952e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ec8\u70b9\u4e4b\u4e00\u30022\uff09MACE+\uff0c\u662f\u6307\u5168\u56e0\u6b7b\u4ea1\u3001\u5352\u4e2d\u3001\u5fc3\u808c\u6897\u6b7b\u4e8b\u4ef6\u4ee5\u53ca\u56e0\u5fc3\u8870\u6216\u8005\u4e0d\u7a33\u5b9a\u5fc3\u7ede\u75db\u9700\u8981\u4f4f\u9662\u7684\u590d\u5408\u7ec8\u70b9\uff0c\u662f\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA<span style=\"font-size: 14px;letter-spacing: 2px;\">\uff09<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6bd4\u8f83<\/span>\u8ba4\u53ef\u7684\u9996\u8981\u5b89\u5168\u6027\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<section class=\"RankEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;margin-top: 20px;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<p style=\"min-height: 1em;white-space: normal;color: rgb(62, 62, 62);line-height: 1.6;font-size: 11px;text-align: center;margin-left: 8px;margin-right: 8px;\"><span style=\"color:rgb(255,140,0);\"><strong>\u25c6<\/strong><\/span><strong><span style=\"color:rgb(255,140,0);\"> <\/span>&nbsp;<span style=\"color: rgb(255,140,0);\">\u25c6 <\/span>&nbsp;<span style=\"color: rgb(255,140,0);\">\u25c6<\/span><\/strong><\/p>\n<section style=\"text-align:center;\">\n<p style=\"color: rgb(121, 121, 121);font-weight: bold;margin-left: 8px;margin-right: 8px;\"><span style=\"color: rgb(255, 76, 0);font-size: 15px;letter-spacing: 2px;\">\u7f57\u6c99\u53f8\u4ed6\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c<\/span><\/p>\n<\/section>\n<section style=\"width: 0px;height: 0px;clear: both;\"><\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><span style=\"background-color: rgb(255, 255, 255);\">FibroGen<\/span>\u5b98\u7f51\u6b64\u6b21\u53d1\u5e03\u7684\u65b0\u95fb\uff0c\u63d0\u4f9b\u4e86\u7f57\u6c99\u53f8\u4ed6\u57283\u7c7b\u6162\u6027\u80be\u6027\u8d2b\u8840\u60a3\u8005\u4e2d\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u5206\u6790\u7b80\u8981\u7ed3\u679c\u3002\u5177\u4f53\u5982\u4e0b\uff1a<span style=\"max-width: 100%;background-color: rgb(255, 255, 255);font-size: 14px;letter-spacing: 2px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 2em;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u900f\u6790\u4f9d\u8d56\u6027\u6162\u6027\u80be\u75c5\u60a3\u8005\uff08DD-CKD\u60a3\u8005\uff09\uff1a<\/span><\/strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6c47\u603b\u5206\u6790\u4e86\u7ea64000\u4f8bDD-CKD\u60a3\u8005\u7684\u6570\u636e\uff0c\u9996\u6b21\u53d1\u751fMACE+\u7684\u76f8\u5bf9\u98ce\u9669\u768495% CI\uff08\u7f6e\u4fe1\u533a\u95f4\uff09\u7684\u4e0a\u9650\u5c0f\u4e8e\u9884\u5148\u8bbe\u5b9a\u7684\u975e\u52a3\u6548\u6027\u754c\u9650\u3002\u636e\u6b64\u8ba4\u4e3a\uff0c\u7f57\u6c99\u53f8\u4ed6\u4e0e\u963f\u6cd5\u4f9d\u6cca\u6c40\u7684MACE\u98ce\u9669\u5728\u8fd9\u7c7b\u60a3\u8005\u7fa4\u4f53\u4e2d\u6ca1\u6709\u4e34\u5e8a\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/strong><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u65b0\u53d1\u900f\u6790\u4e8b\u4ef6\u6162\u6027\u80be\u75c5\u60a3\u8005\uff08<span style=\"font-size: 14px;letter-spacing: 2px;\">ID-CKD\u60a3\u8005<\/span>\uff09\uff1a<\/span><\/strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6c47\u603b\u5206\u6790\u4e861500\u591a\u4f8bID-CKD\u60a3\u8005\uff08DD-CKD\u60a3\u8005\u7684\u4e9a\u7ec4\uff09\u7684\u6570\u636e\u3002\u5728\u9996\u6b21\u51fa\u73b0MACE+\u4e8b\u4ef6\u8fd9\u4e00\u6307\u6807\u4e0a\uff0c\u7f57\u6c99\u53f8\u4ed6\u4f18\u4e8e\u963f\u6cd5\u4f9d\u6cca\u6c40\u3002\u5728MACE\u5b89\u5168\u6027\u65b9\u9762\uff0c\u7f57\u6c99\u53f8\u4ed6\u76f8\u6bd4<span style=\"font-size: 14px;letter-spacing: 2px;\">\u963f\u6cd5\u4f9d\u6cca\u6c40<\/span>\u5177\u6709\u964d\u4f4eMACE\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u8d8b\u52bf\u3002<\/span><\/p>\n<p style=\"line-height: 2em;\"><br  \/><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u975e\u900f\u6790\u4f9d\u8d56\u6027\u6162\u6027\u80be\u75c5\u60a3\u8005\uff08NDD-CKD\u60a3\u8005\uff09\uff1a<\/span><\/strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6c47\u603b\u5206\u6790\u4e86\u7ea64300\u4f8bNDD-CKD\u60a3\u8005\u7684\u6570\u636e\uff0c\u57fa\u4e8e95% CI\u7684\u4e0a\u9650\u5c0f\u4e8e\u9884\u5148\u8bbe\u5b9a\u7684\u975e\u52a3\u6548\u6027\u754c\u9650\uff0c\u8ba4\u4e3a\u7f57\u6c99\u53f8\u4ed6\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5728\u9996\u6b21\u53d1\u751fMACE+\u65b9\u9762\u7684\u5b89\u5168\u6027\u4e3a\u975e\u52a3\u6548\u6027\u3002\u7f57\u6c99\u53f8\u4ed6\u4e0e\u5b89\u6170\u5242\u5728MACE\u98ce\u9669\u65b9\u9762\u6ca1\u6709\u4e34\u5e8a\u610f\u4e49\u5dee\u5f02\u3002MACE\u548cMACE+\u5b89\u5168\u6027\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u4f7f\u7528ITT\u5206\u6790\u8868\u660e\u7f57\u6c99\u53f8\u4ed6\u4e0e\u5b89\u6170\u5242\u76f8\u5f53\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"text-indent: 38px;font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"text-indent: 38px;font-size: 14px;letter-spacing: 2px;\">\u4e0a\u9762\u8fd9\u4e9b\u4fe1\u606f\u521d\u4e00\u770b\u786e\u5b9e\u6709\u4e9b\u6666\u6da9\uff0c\u975e\u884c\u4e1a\u4eba\u58eb\u5f88\u96be\u7406\u89e3\u8fd9\u4e9b\u5b89\u5168\u6027\u7ed3\u679c\u7684\u5b9a\u6027\u8868\u8ff0\u5bf9\u4e8e\u8fd9\u4e2afirst in class\u65b0\u836f\u5728\u6b27\u7f8e\u4e0a\u5e02\u524d\u666f\u7684\u610f\u4e49\u3002FibroGen\u5b98\u7f51\u65b0\u95fb\u7a3f\u4e2d\u8fd8\u7279\u522b\u6307\u51fa\uff1a<\/span><span style=\"text-indent: 38px;color: rgb(0, 82, 255);\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u4e0a\u8ff0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u5206\u6790\u91c7\u7528\u7684\u662f1.3\u7684\u975e\u52a3\u6548\u754c\u503c<\/span><\/strong><\/span><span style=\"text-indent: 38px;font-size: 14px;letter-spacing: 2px;\">\u3002\u8fd9\u53e5\u8bdd\u66f4\u662f\u5bb9\u6613\u88ab\u5927\u5bb6\u5ffd\u7565\uff0c\u4f46\u80cc\u540e\u7684\u4fe1\u606f\u91cf\u5176\u5b9e\u662f\u5f88\u5927\u7684\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"text-indent: 38px;font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<section class=\"RankEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;margin-top: 20px;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<p style=\"min-height: 1em;white-space: normal;color: rgb(62, 62, 62);line-height: 1.6;font-size: 11px;text-align: center;margin-left: 8px;margin-right: 8px;\"><span style=\"color:rgb(255,140,0);\"><strong>\u25c6<\/strong><\/span><strong><span style=\"color:rgb(255,140,0);\"> <\/span>&nbsp;<span style=\"color: rgb(255,140,0);\">\u25c6 <\/span>&nbsp;<span style=\"color: rgb(255,140,0);\">\u25c6<\/span><\/strong><\/p>\n<section style=\"text-align:center;\">\n<p style=\"color: rgb(121, 121, 121);font-weight: bold;margin-left: 8px;margin-right: 8px;\"><span style=\"color: rgb(255, 76, 0);letter-spacing: 2px;font-size: 15px;\">\u4f55\u4e3a1.3\u975e\u52a3\u6548\u754c\u503c<\/span><\/p>\n<\/section>\n<section style=\"width: 0px;height: 0px;clear: both;\"><\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"text-indent: 38px;font-size: 14px;letter-spacing: 2px;\">\u5982\u679c\u662f\u719f\u6089\u7cd6\u5c3f\u75c5\u65b0\u53d1\u548c\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u8bc4\u4f30\u7684\u670b\u53cb\uff0c\u5bf9\u8fd9\u53e5\u8bdd\u5e94\u8be5\u4e0d\u4f1a\u611f\u5230\u964c\u751f\u3002<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA4MDA4MTIzMg==&amp;mid=402143808&amp;idx=1&amp;sn=54164f033ad1ecbb8d419c33da45e812&amp;chksm=0da5227f3ad2ab696deb92466d86802957ded476b97b1f760c93f822cd14fc5c93b757371654&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"text-decoration: underline;font-size: 14px;letter-spacing: 2px;\" >\u6587\u8fea\u96c5\u4e8b\u4ef6<\/a><span style=\"font-size: 14px;letter-spacing: 2px;\">\u540e\uff0cFDA\u5bf9\u7cd6\u5c3f\u75c5\u65b0\u836f\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7684\u8981\u6c42\u6b63\u662f\u91c7\u7528\u201c1.3\u7684\u975e\u52a3\u6548\u754c\u503c\u201d\u3002<\/span><\/p>\n<p style=\"line-height: 2em;\"><br  \/><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"text-indent: 32px;font-size: 14px;letter-spacing: 2px;\">2007\u5e74NEJM\u7684\u4e00\u7bc7\u835f\u8403\u5206\u6790\uff08meta analysis\uff09\u6587\u7ae0\u6307\u51fa\u7f57\u683c\u5217\u916e\u4f1a\u589e\u52a0\u5fc3\u8840\u7ba1\u98ce\u9669\uff0c\u968f\u540e2008\u5e74FDA\u53d1\u5e03\u6307\u5357\u8981\u6c42\u6240\u6709\u7cd6\u5c3f\u75c5\u836f\u7269\u5f00\u5c55\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002FDA\u6307\u5357\u5bf9\u8bc4\u4f30\u7cd6\u5c3f\u75c5\u836f\u7269\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u4e2d\uff0c\u63a8\u8350\u5206\u4ee5\u4e0b\u4e09\u79cd\u60c5\u5f62\uff08\u7533\u8bf7\u4e0a\u5e02\u524d\uff0c\u6b64\u5916\u8981\u6c42\u835f\u8403\u5206\u6790\u62a5\u544a\u56ca\u62ec\u5145\u8db3\u7684\u8be6\u7ec6\u8d44\u6599\uff09\uff1a<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;text-indent: 32px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;text-indent: 32px;\">1\uff09II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e0e\u5bf9\u7167\u7ec4\u7684\u5b89\u5168\u6027\u4e8b\u4ef6\u6574\u5408\u5206\u6790\uff08\u835f\u8403\u5206\u6790\uff09\uff0c\u6bd4\u8f83\u8bd5\u9a8c\u7ec4\u76f8\u5bf9\u98ce\u9669\uff08risk ratio\uff09\u768495%\u53cc\u4fa7\u7f6e\u4fe1\u533a\u95f4\u4e0a\u9650\u5c0f\u4e8e1.8\u3002\u5982\u679c\u5927\u4e8e1.5\u53c8\u5c0f\u4e8e1.8\uff0c\u5219\u5728\u63d0\u4ea4\u4e0a\u5e02\u524d\u9700\u8981\u589e\u52a0\u4e00\u4e2a\u5927\u578b\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">2\uff09\u5982\u679c\u4e0a\u5e02\u7533\u8bf7\u524d\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u8bd5\u9a8c\u7ec4\u589e\u52a0\u76f8\u5bf9\u98ce\u9669\u768495%\u53cc\u4fa7\u7f6e\u4fe1\u533a\u95f4\u4e0a\u9650\u5927\u4e8e1.3\u5c0f\u4e8e1.8\uff0c\u5219\u9700\u8981\u4e0a\u5e02\u540e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u8981\u6c42\u76f8\u5bf9\u98ce\u9669\u768495%\u53cc\u4fa7\u7f6e\u4fe1\u533a\u95f4\u4e0a\u9650\u5c0f\u4e8e1.3\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">3\uff09\u5982\u679c\u4e0a\u5e02\u7533\u8bf7\u524d\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u8bd5\u9a8c\u7ec4\u76f8\u5bf9\u98ce\u9669\u768495%\u53cc\u4fa7\u7f6e\u4fe1\u533a\u95f4\u4e0a\u9650\u5c0f\u4e8e1.3\u4e14\u603b\u4f53\u6548\u76ca\u98ce\u9669\u6bd4\u652f\u6301\u6279\u51c6\uff0c\u5219\u53ef\u80fd\u4e0d\u9700\u8981\u4e0a\u5e02\u540e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558510964.jpg\" alt=\"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790\" title=\"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790\"  \/><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.5em;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">\u6765\u6e90\uff1aEndocrinologic and Metabolic Drugs Advisory Committee Meeting October24-25, 2018. Introductory Remarks<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">.<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"font-family: 0 8px 0;line-height: 32px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u603b\u4f53\u6765\u8bf4\uff0c\u5c31\u662f\u8981\u6c42\u5728\u65b0\u836f\u4e0a\u5e02\u524d\u8bc1\u660e\u5176\u5fc3\u8840\u7ba1\u98ce\u9669\u5c0f\u4e8e1.8<\/span><\/strong><strong><span style=\"font-size:14px;color:red;letter-spacing:2px;\">\uff08\u4ea6\u5373\u6392\u9664\u5927\u4e8e1.8\uff09<\/span><\/strong><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\uff0c\u4e0a\u5e02\u540e\u5fc3\u8840\u7ba1\u98ce\u9669\u5c0f\u4e8e1.3<\/span><\/strong><strong><span style=\"font-size:14px;color:red;letter-spacing:2px;\">\uff08\u4ea6\u5373\u6392\u9664\u5927\u4e8e1.3\uff09<\/span><\/strong><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u3002<\/span><\/strong><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><br  \/><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">2008\u5e74\u4e4b\u540e\uff0c\u6709\u7684\u7cd6\u5c3f\u75c5\u65b0\u836f\u5728\u83b7\u6279\u4e4b\u524d\u5c31\u5df2\u7ecf\u542f\u52a8\u4e86\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u8bd5\u9a8c\uff08\u5982\u6069\u683c\u5217\u51c0\uff09\uff0c\u6709\u7684\u5728\u83b7\u6279\u4e4b\u524d\u5e76\u672a\u542f\u52a8\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u8bd5\u9a8c\uff08\u5982\u5229\u62c9\u9c81\u80bd\uff09\u3002\u4ee5\u7b2c\u4e00\u4e2a\u964d\u4f4e\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u7cd6\u5c3f\u75c5\u65b0\u836f\u6069\u683c\u5217\u51c0\u4e3a\u4f8b\uff0c\u5176\u4e0a\u5e02\u524d\u7684\u5927\u578b\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u8bd5\u9a8cEMPA-REG\u7814\u7a76\u7684\u4e2d\u671f\u5206\u6790<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u4e0d<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7b26\u5408\u4e0a\u9650\u5c0f\u4e8e1.3\u7684\u8981\u6c42\uff08HR 0.74\uff0c95%CI\uff1a0.4-1.4\uff09\uff0c\u56e0\u6b64\u4e0a\u5e02\u540e\u7ee7\u7eed\u8fdb\u884c\u5fc3\u8840\u7ba1\u5b89\u5168\u7814\u7a76\uff0c\u6700\u7ec8\u7ed3\u679c\u662fMACE\/MACE+\u5b89\u5168\u6027\u76f8\u5bf9\u98ce\u966995%\u4e0a\u9650\u8fbe\u5230\u975e\u52a3\u6548\u6027\uff08\u5c0f\u4e8e1.3\uff09\uff0cMACE\u8fd8\u662f\u4f18\u6548\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u5176\u4ed6\u836f\u7269\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\uff0c\u5982COX-2\u6291\u5236\u5242\uff0c\u4e5f\u662f\u91c7\u75281.3\u7684\u5b89\u5168\u6027\u975e\u52a3\u6548\u754c\u503c\u3002COX-2\u6291\u5236\u5242\uff08\u7279\u522b\u662f\u4e07\u6d1b\uff09\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u4e5f\u66fe\u95f9\u5f97\u6cb8\u6cb8\u626c\u626c\uff0c\u540e\u6765\u8f89\u745e\u5728FDA\u7684\u8981\u6c42\u4e0b\u5f00\u5c55\u4e86\u585e\u6765\u6614\u5e03\u76842.4\u4e07\u4f8b\u60a3\u8005\u7684\u5927\u578b\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u8bd5\u9a8c\uff08PRECISION\u7814\u7a76\uff09,\u6700\u7ec8\u8bc1\u660e\u4e86\u585e\u6765\u6614\u5e03\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\uff0cPRECISION\u4e34\u5e8a\u4e2d\u4f7f\u7528\u7684\u5c31\u662f1.3\u7684\u5b89\u5168\u6027\u975e\u52a3\u6548\u754c\u503c\uff08\u89c1\uff1a<\/span><span style=\"font-size: 14px;letter-spacing: 2px;text-decoration: underline;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA4MDA4MTIzMg==&amp;mid=2653045307&amp;idx=1&amp;sn=e2030635f4d7d660ed671188e1223beb&amp;chksm=847f5a04b308d3124e217a9cbea69fbd36001fe829c835474df9825b04fe921e364de76a5397&amp;scene=21#wechat_redirect\" target=\"_blank\"  >2.4\u4e07\u4eba\u8d85\u5927\u578bPRECISION\u7814\u7a76\u7ed3\u679c\u91cd\u78c5\u63ed\u6653\uff1a\u8ba9\u585e\u6765\u6614\u5e03\u91cd\u8fd4\u8363\u5149\uff0c\u4e3a\u5236\u836f\u884c\u4e1a\u6b63\u540d\uff01<\/a><\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\uff09\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<section class=\"RankEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;margin-top: 20px;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<p style=\"min-height: 1em;white-space: normal;color: rgb(62, 62, 62);line-height: 1.6;font-size: 11px;text-align: center;margin-left: 8px;margin-right: 8px;\"><span style=\"color:rgb(255,140,0);\"><strong>\u25c6<\/strong><\/span><strong><span style=\"color:rgb(255,140,0);\"> <\/span>&nbsp;<span style=\"color: rgb(255,140,0);\">\u25c6 <\/span>&nbsp;<span style=\"color: rgb(255,140,0);\">\u25c6<\/span><\/strong><\/p>\n<section style=\"text-align:center;\">\n<p style=\"color: rgb(121, 121, 121);font-weight: bold;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;letter-spacing: 2px;color: rgb(255, 76, 0);\">\u7f57\u6c99\u53f8\u4ed6\u5168\u7403\u4e0a\u5e02\u524d\u666f\u5982\u4f55\uff1f<\/span><\/p>\n<\/section>\n<section style=\"width: 0px;height: 0px;clear: both;\"><\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7ed5\u8fdc\u4e86\uff0c\u6211\u4eec\u56de\u5230\u5982\u4f55\u770b\u5f85\u7f57\u6c99\u53f8\u4ed6\u5168\u7403\u5fc3\u8840\u7ba1\u5b89\u5168\u6027<span style=\"font-size: 14px;letter-spacing: 2px;\">pool<span style=\"font-size: 14px;letter-spacing: 2px;\">ed<\/span> analysis<\/span>\u7ed3\u679c\u8fd9\u4e2a\u8bdd\u9898\u4e0a\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"color: rgb(0, 0, 0);\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7b2c\u4e00\u3001<\/span><\/strong><\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6162\u6027\u80be\u75c5\u8d2b\u8840\u4f1a\u52a0\u5267\u60a3\u8005\u80be\u529f\u80fd\u51cf\u9000\uff0c\u589e\u52a0\u60a3\u8005\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u4e0e\u6b7b\u4ea1\u98ce\u9669\uff08\u6b64\u7c7b\u8d2b\u8840\u5f15\u8d77\u7684\u5e76\u53d1\u75c7\u6700\u4e3b\u8981\u662f\u5fc3\u529b\u8870\u7aed\uff0c\u6216\u8005\u7a81\u7136\u95f4\u8111\u8840\u4f9b\u5e94\u4e0d\u8db3-\u8111\u5352\u4e2d\uff09\u3002<span style=\"font-size: 14px;letter-spacing: 2px;\">\u5bf9\u4e8e\u521a\u5f00\u59cb\u4e0d\u7a33\u5b9a\u900f\u6790\u7684CKD\u60a3\u8005\uff08ID-CKD\u60a3\u8005\uff09\uff0c\u7f57\u6c99\u53f8\u4ed6\u7684MACE+\u98ce\u9669\u4f18\u4e8e\u6807\u51c6\u7597\u6cd5\u963f\u6cd5\u4f9d\u6cca\u6c40\uff0cMACE\u8d8b\u5411\u4f18\u4e8e\u963f\u6cd5\u4f9d\u6cca\u6c40\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c<\/span>\u7f57\u6c99\u53f8\u4ed6\u53ef\u4ee5\u964d\u4f4e\u65b0\u53d1ID-CKD\u60a3\u8005\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7b2c\u4e8c\u3001<\/span><\/strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7f57\u6c99\u53f8\u4ed6\u6cbb\u7597DD-CKD\u60a3\u8005\u548cNDD-CKD\u60a3\u8005\u7684MACE+\u5b89\u5168\u6027\u90fd\u5c0f\u4e8e\u7cd6\u5c3f\u75c5\u836f\u7269\u5fc3\u8840\u7ba1\u5b89\u5168\u76841.3\u975e\u52a3\u6548\u754c\u503c\uff0c\u6b64\u65b9\u9762\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\uff0c\u6309FDA\u4ee5\u5f80\u7684\u8981\u6c42\u6ca1\u6709\u95ee\u9898\u3002\u5982\u679c\u6362\u505a\u652f\u6301\u8bc1\u636e\u8db3\u7684<span style=\"font-size: 14px;letter-spacing: 2px;\">\u7cd6\u5c3f\u75c5\u836f\u7269<\/span>\uff0c\u53ef\u80fd\u90fd\u4e0d\u9700\u8981\u4e0a\u5e02\u540e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7b2c\u4e09\u3001<\/span><\/strong><span style=\"font-size: 14px;letter-spacing: 2px;\">DD-CKD\u60a3\u8005\u548cNDD-CKD\u60a3\u8005\u7684MACE\u5b89\u5168\u6027\u4e8e\u6807\u51c6\u7597\u6cd5\u76f8\u6bd4\u65e0\u4e34\u5e8a\u610f\u4e49\u7684\u5dee\u5f02\uff0c\u6295\u8d44\u4eba\u552f\u4e00\u7684\u5fe7\u8651<span style=\"font-size: 14px;letter-spacing: 2px;\">\u53ef\u80fd<\/span>\u6765\u6e90\u4e8e\u6b64\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">FDA\u6279\u51c6\u7684\u7cd6\u5c3f\u75c5\u836f\u7269\u4e2d\uff0c\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ec8\u70b9\u6709\u7684\u4f7f\u7528MACE\uff08\u7d22\u9a6c\u9c81\u80bd\uff09\uff0c\u6709\u7684\u4f7f\u7528MACE+(ertugliflozin\uff0c\u57c3\u683c\u5217\u51c0)\uff0c\u6709\u7684\u540c\u65f6\u4f7f\u7528MACE\/MACE+\uff08\u6069\u683c\u5217\u51c0\u3001\u963f\u5fc5\u9c81\u6cf0<span style=\"font-size: 14px;letter-spacing: 2px;\">\uff09<\/span>\uff0c\u5176\u5b9e\u4f7f\u7528\u54ea\u4e2a\u65e0\u6240\u8c13\uff0c\u5173\u952e\u662f\u770b\u5fc3\u8840\u7ba1\u98ce\u9669\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u8fd9\u91cc\u6211\u4eec\u8fd8\u9700\u8981\u6b63\u786e\u7406\u89e3\u5dee\u5f02\u7684\u201c\u4e34\u5e8a\u610f\u4e49<span style=\"font-size: 14px;letter-spacing: 2px;\">\u201d<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u4e0e\u201c<\/span>\u7edf\u8ba1\u5b66\u610f\u4e49\u201d\uff0c\u8fd9\u662f\u5b8c\u5168\u4e0d\u540c\u7684\u4e24\u4e2a\u6982\u5ff5\u3002\u7edf\u8ba1\u5b66\u6709\u610f\u4e49\u7684\u5dee\u5f02\uff0c\u4e0d\u4e00\u5b9a\u662f\u4e34\u5e8a\u6709\u610f\u4e49\u7684\u5dee\u5f02\uff0c\u53cd\u8fc7\u6765\u4e5f\u662f\u5982\u6b64\u3002\u4e34\u5e8a\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\u548c\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\u5728\u4f5c\u4e3a\u5b89\u5168\u6027\u8bc4\u4f30\u4f9d\u636e\u65f6\uff0c\u6709\u8fd9\u4e48\u51e0\u79cd\u60c5\u51b5\uff1a<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">1\uff09\u5982\u679c\u5dee\u5f02\u5728\u4e34\u5e8a\u4e0a\u548c\u7edf\u8ba1\u5b66\u4e0a\u90fd\u6709\u610f\u4e49\uff0c\u90a3\u5c31\u6ca1\u6709\u8bdd\u597d\u8bf4\u4e86\uff0c\u9700\u8981\u589e\u52a0\u98ce\u9669\u63d0\u793a\uff0c\u53ef\u80fd\u8fd8\u8981\u989d\u5916\u589e\u52a0\u4e34\u5e8a\u8bd5\u9a8c\uff1b2\uff09\u5982\u679c\u5dee\u5f02\u53ea\u662f\u4e34\u5e8a\u610f\u4e49\u4e0a\u800c\u4e0d\u662f\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\uff0c\u6821\u9a8c\u6548\u80fd\u4e0d\u8db3\uff0c\u90a3\u5c31\u53ef\u80fd\u8981\u901a\u8fc7\u52a0\u5927\u6837\u672c\u91cf\u7b49\u65b9\u5f0f\u63d0\u4ea4\u68c0\u9a8c\u6548\u80fd\uff0c\u5f00\u5c55\u65b0\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fd9\u662f\u4e00\u4ef6\u60b2\u4f24\u7684\u4e8b\u60c5\uff1b3\uff09\u60c5\u51b5\u8fd8\u7b97\u597d\u7684\u5c31\u662f\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\uff0c\u4f46\u662f\u65e0\u4e34\u5e8a\u610f\u4e49\u7684\u5dee\u5f02\u4e86\u30024\uff09\u6700\u597d\u7684\u7ed3\u679c\u662f\u65e2\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u5dee\u5f02\uff0c\u4e5f\u65e0\u4e34\u5e8a\u610f\u4e49\u7684\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><br  \/><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u4eceFibroGen\u5b98\u7f51\u65b0\u95fb\u63aa\u8f9e\u4e0a\u770b\uff0cDD-CKD\u60a3\u8005\u548cNDD-CKD\u60a3\u8005\u7684MACE\u5b89\u5168\u6027\u65e0\u4e34\u5e8a\u610f\u4e49\u7684\u5dee\u5f02\u3002\u6700\u574f\u7684\u60c5\u51b5\u53ef\u80fd\u5c31\u662fMACE\u7684\u7edf\u8ba1\u5b66p\u503c\u7a0d\u5fae\u5c0f\u4e8e0.05\uff0c\u800cMACE\u98ce\u9669\u6ca1\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5dee\u5f02\uff0c\u5f53\u7136\u8fd8\u8981\u770b\u8bf8\u5982OR\u503c\u3001RR\u503c\u3001HR\u503c\u300195%CI\u7b49\u3002\u867d\u7136\u6ca1\u6709\u516c\u5e03\u5177\u4f53\u6570\u636e\uff0c\u4f46\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u5e94<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u8be5\u6ca1\u6709\u4ec0\u4e48\u95ee\u9898\u3002\u6162\u6027\u80be\u75c5\u60a3\u8005\u7684\u4e3b\u8981\u5fc3\u8840\u7ba1\u98ce\u9669\u662f\u5fc3\u8870\uff0c\u7f57\u6c99\u53f8\u4ed6\u5f88\u53ef\u80fd\u662f\u5728\u964d\u4f4e\u5fc3\u8870\u548c\u5fc3\u7ede\u75db\u98ce\u9669\u65b9\u9762\u66f4\u597d\u4e00\u4e9b\uff0c\u53d7\u6b64\u9a71\u52a8MACE+\u7565\u5fae\u6bd4MACE\u597d\u4e9b\u3002\u7531\u4e8e\u6ca1\u6709\u5177\u4f53\u6570\u636e\uff0c\u51ed\u63a8\u6d4b\u505a\u4ee5\u4e0b\u56fe\u4f8b\uff0c\u4ec5\u4f9b\u53c2\u8003\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558510964.jpg\" alt=\"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790\" title=\"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><span style=\"font-size: 14px;letter-spacing: 2px;background-color: rgb(255, 255, 255);\">FibroGen<\/span>\u76ee\u524d\u516c\u5e03\u7684\u7f57\u6c99\u53f8\u4ed6pool<span style=\"font-size: 14px;letter-spacing: 2px;\">ed<\/span> analysis\u5206\u6790\u7ed3\u679c\u5176\u5b9e\u662f\u79ef\u6781\u7684\uff0c<\/span><span style=\"font-size: 14px;letter-spacing: 2px;color: rgb(0, 82, 255);\">\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u5e94\u8be5\u4e0d\u4f1a\u6210\u4e3a\u5176\u83b7\u6279\u4e0a\u5e02\u7684\u969c\u788d\uff0c\u83b7\u5f97\u6b27\u7f8e\u6279\u51c6\u4e0a\u5e02\u7684\u6982\u7387\u975e\u5e38\u5927\uff0c\u63a8\u6d4b\u836f\u54c1\u6807\u7b7e\u53ef\u80fd\u4f1a\u67093\u79cd\u60c5\u5f62<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\uff1a\u4e00\u79cd\u662f\u65e0\u98ce\u9669\u63d0\u793a\uff0c\u4e00\u79cd\u662f\u6709\u98ce\u9669\u63d0\u793a\uff0c\u6700\u574f\u7684\u7b2c3\u79cd\u7ed3\u679c\u662f\u63d0\u793a<span style=\"font-size: 14px;letter-spacing: 2px;\">\u98ce\u9669<\/span>\u540c\u65f6\u8981\u6c42\u4f01\u4e1a\u5f00\u5c55\u4e0a\u5e02\u540e\u7814\u7a76\u3002\u5f53\u7136\u6700\u7ec8\u7ed3\u679c\u5982\u4f55\uff0c\u6211\u4eec\u8fd8\u662f\u8981\u770b<span style=\"font-size: 14px;letter-spacing: 2px;background-color: rgb(255, 255, 255);\">FibroGen\u8fdb\u4e00\u6b65\u516c\u5f00\u7684\u5b89\u5168\u6027<\/span>\u6570\u636e\u4ee5\u53ca\u6b27\u7f8e\u76d1\u7ba1\u673a\u6784\u7684\u6279\u51c6\u51b3\u5b9a\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><br  \/><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><strong><span style=\"font-size: 14px;letter-spacing: 2px;\">\u7efc\u5408\u73b0\u6709\u516c\u5f00\u4fe1\u606f\u6765\u770b\uff0c\u7f57\u6c99\u53f8\u4ed6\u5728\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u4e0a\u975e\u52a3\u6548\uff0c\u751a\u81f3\u6709\u90e8\u5206\u4eba\u7fa4\u6bd4\u6807\u51c6\u7597\u6cd5\u963f\u6cd5\u4f9d\u6cca\u6c40\u4f18\u6548\uff0c\u5728\u51cf\u7f13eGFR\uff08\u80be\u6076\u5316\uff09&nbsp;\u3001\u6cbb\u7597\u8d2b\u8840\u65b9\u9762\u5219\u663e\u793a\u4f18\u6548\uff0c\u518d\u52a0\u4e0a\u53e3\u670d\u7ed9\u836f\uff08\u76f8\u5bf9\u4e8eEPO\u7684\u6ce8\u5c04\uff09\u3001\u65e0\u9700\u9759\u8109\u6ce8\u5c04\u8865\u94c1\u3001\u4e0d\u660e\u663e\u5347\u9ad8\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u6c34\u5e73\uff08\u907f\u514dEPO\u7c7b\u4ea7\u54c1\u7684\u4e0d\u826f\u53cd\u5e94\uff09\u65b9\u9762\u7684\u4f18\u52bf\uff0c<span style=\"font-size: 14px;letter-spacing: 2px;\">\u7f57\u6c99\u53f8\u4ed6\u5bf9\u4e8e<\/span>\u6162\u6027\u80be\u75c5\u8d2b\u8840\u60a3\u8005\u603b\u4f53\u6765\u8bf4\u662f\u4e00\u4e2a\u96be\u5f97\u7684\u597d\u836f\u3002<\/span><\/strong><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">\u6700\u540e\u505a\u4e00\u70b9\u5ef6\u4f38\uff0c\u5b89\u5168\u6027\u8bc4\u7684\u7edf\u8ba1\u65b9\u6cd5\u662f\u91c7\u7528<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">pooled analysis<\/span><span style=\"font-size: 14px;letter-spacing: 2px;\">\u8fd8\u662fmeta analysis\uff1f\u5176\u5b9e\u4e24\u79cd\u65b9\u6cd5\u5404\u6709\u4f18\u52a3\u3002\u7ecf\u5e38\u770bFDA\u533b\u5b66\u5ba1\u8bc4\u62a5\u544a\u6216\u8005\u7edf\u8ba1\u65b9\u9762\u5ba1\u8bc4\u62a5\u544a\u7684\u540c\u5b66\uff0c\u5e94\u8be5\u77e5\u9053\u8fd9\u4e24\u79cd\u7edf\u8ba1\u5b66\u65b9\u6cd5\u90fd\u6709\u7528\u4e8e\u836f\u7269\u5b89\u5168\u6027\u5206\u6790\u4e0a\u5e02\u7533\u8bf7\u7684\u6848\u4f8b\uff0c\u6bd4\u5982\u793c\u6765\u7684JAK\u6291\u5236\u5242Baricitinib\u5c31\u662f\u4f7f\u7528pool <span style=\"font-size: 14px;letter-spacing: 2px;\">ed&nbsp;<\/span>analysis\u7ed3\u679c\uff0c\u867d\u7136\u53d1\u73b0\u65e0MACE\u98ce\u9669\uff0c\u4f46\u53d1\u73b0\u5176\u589e\u52a0\u8840\u6813\u98ce\u9669\uff0c\u6240\u4ee5\u6700\u7ec8\u53ea\u6279\u51c6\u4e862mg\u89c4\u683c\u3002\u5bf9pool<span style=\"font-size: 14px;letter-spacing: 2px;\">ed<\/span> analysis\u611f\u5174\u8da3\u7684\u540c\u5b66\u53ef\u4ee5\u770b\u770b\u8bfa\u534e\u516c\u53f8\u7814\u7a76\u4eba\u5458\u5199\u7684\u8d44\u6599\uff0c\u89c1\u6587\u672b\u53c2\u8003\u8d44\u6599[4]\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 2em;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 14px;letter-spacing: 2px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">\u53c2\u8003\u8d44\u6599<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">[1] FibroGen Announces Positive Topline Results from Pooled Safety Analyses of Roxadustat Global Phase 3 Program\uff1ahttp:\/\/phx.corporate-ir.net\/phoenix.zhtml?c=253783&amp;p=irol-newsArticle&amp;ID=2398154<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">[2] Guidancefor Industry Diabetes Mellitus \u2014 Evaluating Cardiovascular Risk in NewAntidiabetic Therapies to Treat Type 2 Diabetes\uff1ahttps:\/\/www.fda.gov\/media\/71297\/download<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">[3]&nbsp;https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1611593<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">[4] Poolingclinical data\uff1akeypoints and pitfalls\uff1ahttps:\/\/lexjansen.com\/phuse\/2012\/dh\/DH01.pdf<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;\"><span style=\"letter-spacing: 2px;font-size: 12px;\">[5] FDA\u76f8\u5173\u836f\u7269\u7684\u533b\u5b66\u5ba1\u8bc4\u62a5\u544a<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558510964.jpeg\" alt=\"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790\" title=\"\u4e2d\u56fd\u4e0a\u5e02\u7684\u9996\u4e2afirst in class\u65b0\u836f\uff0c\u6b27\u7f8e\u4f55\u65f6\u6279\u51c6\uff1f\u7f57\u6c99\u53f8\u4ed6\u6700\u65b0\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u7ed3\u679c\u5206\u6790\"  \/><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;\"><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2019\u5e745\u67089\u65e5\uff0cFibroGen\u548c\u963f\u65af\u5229\u5eb7\u5206\u522b\u5728\u5b98\u7f51\u53d1\u5e03\u6d88\u606f\uff0c\u516c\u5e03\u4e86\u7f57\u6c99\u53f8\u4ed6\u5168\u7403\u591a\u4e2aIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5fc3\u8840\u7ba1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":112369,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/112368"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=112368"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/112368\/revisions"}],"predecessor-version":[{"id":112373,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/112368\/revisions\/112373"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/112369"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=112368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=112368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=112368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}