{"id":112878,"date":"2019-06-11T11:54:42","date_gmt":"2019-06-11T03:53:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/112878\/"},"modified":"2019-06-11T11:53:57","modified_gmt":"2019-06-11T03:53:57","slug":"a767d5241e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/112878\/","title":{"rendered":"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7"},"content":{"rendered":"
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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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 <\/span><\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/span><\/p>\n


<\/p>\n

\u836f\u7269\u7814\u53d1\uff0c\u4e00\u4e2a\u529f\u81e3<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u73b0\u4ee3\u836f\u5b66\u6709\u4e2a\u57fa\u672c\u7684\u89c2\u70b9\uff1a\u5373\u4fbf\u4e00\u79cd\u75be\u75c5\u7684\u75c5\u7406\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u5982\u679c\u6709\u67d0\u79cd\u836f\u7269\u88ab\u8bc1\u660e\u6709\u6548\uff0c\u5b83\u4ecd\u7136\u6709\u673a\u4f1a\u7528\u4e8e\u4e34\u5e8a\uff0c\u5e76\u4e14\u53ef\u80fd\u4f1a\u5e2e\u52a9\u79d1\u5b66\u5bb6\u5012\u63a8\u75c5\u7406\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u6291\u90c1\u75c7\u5c31\u662f\u6cbe\u4e86\u8fd9\u4e2a\u539f\u7406\u7684\u5149\u3002<\/span><\/p>\n


<\/p>\n

\u76f4\u5230\u73b0\u5728\uff0c\u6291\u90c1\u75c7\u7684\u75c5\u7406\u4ecd\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u79d1\u5b66\u5bb6\u4eec\u4ecd\u7136\u5728\u9057\u4f20\u548c\u540e\u5929\u56e0\u7d20\u5171\u540c\u4f5c\u7528\u7684\u5206\u5b50\u7f51\u4e2d\u6478\u722c\u6eda\u6253\u3002<\/span><\/p>\n


<\/p>\n

\u4e0d\u8fc7\uff0c\u5728\u6700\u5173\u952e\u7684\u4e00\u70b9\u4e0a\uff0c\u4eba\u4eec\u662f\u8d8a\u6765\u8d8a\u786e\u5b9a\u7684\uff1a\u6291\u90c1\u75c7\u8ddf\u611f\u5192\u3001\u7cd6\u5c3f\u75c5\u3001\u5fc3\u810f\u75c5\u4e00\u6837\uff0c\u662f\u4e00\u79cd\u5982\u5047\u5305\u6362\u7684\u8eab\u4f53\u75be\u75c5\u3002\u5b83\u80fd\u591f\u88ab\u5316\u5b66\u836f\u7269\u6709\u6548\u6cbb\u7597\u3002<\/span><\/p>\n


<\/p>\n

\u5168\u7403\u836f\u7269\u5171\u540c\u4f53\u7684\u8bde\u751f\u662f\u4e00\u4ef6\u975e\u5e38\u665a\u7684\u4e8b\u60c5\u3002\u4eca\u5929\u6211\u4eec\u6240\u77e5\u9053\u7684\u5236\u836f\u5de8\u5934\uff0c\u8f89\u745e\u8bde\u751f\u4e8e 1849 \u5e74\uff0c\u7f57\u6c0f\u59cb\u521b\u4e8e 1896 \u5e74\uff0c\u8bfa\u534e\u7684\u4e09\u4e2a\u6bcd\u516c\u53f8\u5219\u76f4\u5230 1900 \u5e74\u524d\u540e\u624d\u5f00\u59cb\u5de5\u4e1a\u751f\u4ea7\u5316\u5b66\u836f\u7269\u3002<\/span><\/p>\n


<\/p>\n

\u4e00\u767e\u591a\u5e74\u95f4\uff0c\u4eba\u7c7b\u5236\u9020\u7684\u3001\u80fd\u591f\u5355\u72ec\u6210\u836f\u7684\u5316\u5b66\u5206\u5b50\u4e0d\u8d85\u8fc7\u4e00\u4e07\u4e2a\u3002\u5982\u679c\u628a\u5b83\u4eec\u5f52\u5f52\u7c7b\uff0c\u300c\u9aa8\u67b6\u957f\u5f97\u50cf\u300d\u7684\u7b97\u4f5c\u540c\u4e00\u4e2a\uff0c\u5c31\u53ea\u5269\u4e0b\u4e00\u5343\u591a\u4e2a\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7\"<\/p>\n

1993 ~ 2018\u5e74\uff0cFDA \u6279\u51c6\u7684\u65b0\u5206\u5b50\u5b9e\u4f53\u836f\u7269\uff08NME\uff09\u548c\u751f\u7269\u5236\u54c1\u4e0a\u5e02\uff08BLA\uff09\u6570\u91cf\u3002\u6bcf\u5e74\u51e0\u5341\u4e2a\u836f\u80cc\u540e\uff0c\u662f\u5343\u4ebf\u89c4\u6a21\u7684\u7814\u53d1\u6295\u5165\uff0c\u56e0\u4e3a\u628a\u4e00\u4e2a\u836f\u505a\u5230\u4e0a\u5e02\u9700\u8981\u6570\u5341\u4ebf\u7f8e\u5143<\/span><\/p>\n

\uff08\u56fe\u7247\u6765\u81ea Nature Reviews\uff09<\/span><\/p>\n


<\/p>\n

\u8003\u8651\u5230 ICD-10-PCS \u75be\u75c5\u76ee\u5f55\u6709\u516b\u4e07\u4e03\u5343\u4e2a\u6761\u76ee\uff0c\u6211\u4eec\u4e0d\u5f97\u4e0d\u6b63\u89c6\u4e00\u4e2a\u73b0\u5b9e\uff1a\u5927\u91cf\u4eba\u7c7b\u75be\u75c5\uff0c\u5176\u5b9e\u662f\u6ca1\u6709\u5bf9\u5e94\u836f\u7684\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u4e0d\u662f\u50cf\u963f\u5c14\u5179\u6d77\u9ed8\uff0c\u5f00\u53d1\u51fa\u7684\u836f\u7269\u6700\u7ec8\u90fd\u786e\u8ba4\u65e0\u6548\uff1b\u4e5f\u4e0d\u50cf\u9611\u5c3e\u708e\uff0c\u4e3b\u8981\u9760\u624b\u672f\u89e3\u51b3\u95ee\u9898\uff1b\u4e5f\u4e0d\u662f\u50cf\u666e\u901a\u611f\u5192\uff0c\u836f\u7269\u5168\u90fd\u300c\u6cbb\u6807\u4e0d\u6cbb\u672c\u300d\u3002\u8fd9\u4e09\u8005\u8fd8\u5c5e\u4e8e\u5e78\u8fd0\u7684\u75be\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e9b\u4e0d\u5e78\u7684\u75be\u75c5\u6839\u672c\u6ca1\u6709\u53d7\u5230\u8fc7\u836f\u7269\u7814\u53d1\u548c\u836f\u7269\u5e02\u573a\u7684\u9752\u7750\uff0c\u6ca1\u6709\u4e00\u4e2a\u300c\u5341\u4ebf\u7f8e\u5143\u300d\u6295\u7ed9\u4e86\u5b83\u4eec\u3002\u4e16\u754c\u4e0a\u7684 7000 \u79cd\u7f55\u89c1\u75c5\uff0c\u5927\u90e8\u5206\u90fd\u5c5e\u4e8e\u8fd9\u79cd\u60c5\u51b5\u3002\u5b83\u4eec\u4e0d\u80fd\u81ea\u884c\u75ca\u6108\uff0c\u6ca1\u6709\u624b\u672f\u4e4b\u7c7b\u7684\u5907\u9009\u65b9\u6848\uff0c\u53ea\u80fd\u88ab\u6b7b\u4ea1\u5e26\u8d70\u3002<\/span><\/p>\n


<\/p>\n

\u6291\u90c1\u75c7\u66fe\u7ecf\u4e5f\u5c5e\u4e8e\u8fd9\u4e2a\u4e0d\u5e78\u7684\u884c\u5217\u3002\u5728\u4eba\u7c7b\u5386\u53f2\u7684\u5927\u90e8\u5206\u65f6\u671f\uff0c\u4eba\u4eec\u751a\u81f3\u90fd\u641e\u4e0d\u6e05\u695a\u5b83\u7a76\u7adf\u662f\u4e0d\u662f\u4e00\u4e2a\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7\"<\/p>\n

\u4e22\u52d2\u7684\u94dc\u7248\u753b\u300a\u5fe7\u90c1\u300b<\/span>\uff081514\u5e74\uff09\uff0c\u5f53\u65f6\u4eba\u4eec\u8ba4\u4e3a\u5fe7\u90c1\u548c\u7406\u6027\u7cbe\u795e\u6709\u5173<\/span><\/p>\n


<\/p>\n

\u5728 1968 \u5e74\u51fa\u7248\u7684\u7f8e\u56fd\u300a\u7cbe\u795e\u75be\u75c5\u8bca\u65ad\u4e0e\u7edf\u8ba1\u624b\u518c\u300bDSM-II \u76ee\u5f55\u91cc\uff0c\u6291\u90c1\u75c7\u8fd8\u4e0d\u662f\u4e00\u4e2a\u75c5\uff0c\u800c\u662f\u4e24\u4e2a\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e24\u4e2a\u75c5\uff0c\u4e00\u79cd\u662f\u300c\u5e94\u6fc0\u6027\u6291\u90c1\u7cbe\u795e\u75c5<\/strong>\uff08 298.0 Reactive depressive psichosis\uff09\u300d\u3002\u5b83\u7ee7\u627f\u4e86\u5f17\u6d1b\u4f0a\u5fb7\u7684\u300c\u4e3b\u89c2\u635f\u5931\u300d\u903b\u8f91\uff0c\u88ab\u8ba4\u4e3a\u662f\u4eb2\u53cb\u6b7b\u4ea1\u6216\u8005\u5931\u604b\u7b49\u7cbe\u795e\u523a\u6fc0\u5e26\u6765\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u4e00\u79cd\u662f\u300c\u6291\u90c1\u6027\u795e\u7ecf\u75c7<\/strong>\uff08 300.4 Depressive neurosis\uff09\u300d\uff0c\u5b83\u867d\u7136\u4e5f\u5305\u542b\u5e94\u6fc0\u7684\u6210\u5206\uff0c\u4f46\u66f4\u50cf\u4f53\u6db2\u7406\u8bba\u7684\u5ef6\u4f38\uff0c\u662f\u4e00\u79cd\u5fc3\u7406-\u8eaf\u4f53\u75be\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u89e3\u91ca\u75c5\u7406\u65b9\u9762\uff0c\u4f53\u6db2\u7406\u8bba\u5c31\u8ddf\u9634\u9633\u4e94\u884c\u4e00\u6837\u6ca1\u4ec0\u4e48\u53c2\u8003\u4ef7\u503c\u3002\u4f46\u5b83\u4eec\u81f3\u5c11\u63d0\u51fa\u4e86\u4e00\u4e2a\u91cd\u8981\u7684\u731c\u60f3\uff1a\u6291\u90c1\u75c7\u662f\u4e00\u79cd\u8eab\u4f53\u75be\u75c5\uff0c\u662f\u8eab\u4f53\u67d0\u79cd\u673a\u80fd\u51fa\u73b0\u4e86\u5f02\u5e38\uff0c\u800c\u4e0d\u5355\u662f\u7cbe\u795e\u5c42\u9762\u7684\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

\u6240\u4ee5\uff0c\u300c5-\u7f9f\u8272\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242<\/strong>\u300d\u7684\u51fa\u73b0\u5c31\u663e\u5f97\u5f25\u8db3\u73cd\u8d35\u3002\u5b83\u8bc1\u660e\u4e86\u8fd9\u4e2a\u731c\u60f3\u662f\u6b63\u786e\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u300c5-\u7f9f\u8272\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242\u300d\uff08SSRI\uff09\u7c7b\u836f\u7269\u6700\u521d\u662f\u4e3a\u4e86\u66ff\u4ee3\u5b89\u5b9a\u3001\u5229\u7720\u5b81\u7b49\u5bb9\u6613\u4ea7\u751f\u4f9d\u8d56\u7684\u9547\u9759\u5242\u8bde\u751f\u7684\uff0c\u4e3a\u4e86\u5bf9\u6297\u7126\u8651\u3002\u53d1\u73b0\u5b83\u4eec\u66f4\u9002\u5408\u6297\u6291\u90c1\uff0c\u4e0d\u8fc7\u662f\u4e2a\u610f\u5916\u7684\u4ea7\u7269\uff0c\u56e0\u4e3a\u7126\u8651\u548c\u6291\u90c1\u662f\u7cbe\u795e\u75be\u75c5\u7684\u4e00\u4f53\u4e24\u9762\uff0c\u5e38\u5e38\u4e00\u540c\u51fa\u73b0\u3002<\/span><\/p>\n


<\/p>\n

\u5728 20 \u4e16\u7eaa 70 \u5e74\u4ee3\u4ee5\u524d\uff0c\u7126\u8651\u88ab\u8ba4\u4e3a\u662f\u5e74\u8f7b\u5973\u6027\u7684\u5e38\u89c1\u75c5\uff1b\u800c\u6291\u90c1\u4e3b\u8981\u5c5e\u4e8e\u4e2d\u8001\u5e74\u4eba\uff0c\u5e76\u4e14\u53d1\u751f\u7387\u4e0d\u9ad8\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7\"<\/p>\n

\u6587\u62c9\u6cd5\u8f9b 1998 \u5e74\u520a\u767b\u5728 American Journal of Psychiatry \u4e0a\u7684\u5e7f\u544a\u3002\u51e0\u4e4e\u6240\u6709\u7684\u6297\u6291\u90c1\u548c\u7126\u8651\u836f\u7269\u5e7f\u544a\u4e2d\u51fa\u73b0\u7684\u4eba\u7269\u90fd\u662f\u5973\u6027<\/span><\/p>\n


<\/p>\n

\u5728 60 \u5e74\u4ee3\u672b\uff0c\u53ea\u6709 16-18% \u7684\u7f8e\u56fd\u57ce\u5e02\u5c45\u6c11\u81ea\u8ba4\u4e3a\u81f3\u5c11\u51fa\u73b0\u8fc7\u4e00\u6b21\u6291\u90c1\u75c7\u72b6\u3002\u5728\u4eca\u5929\uff0c\u8fd9\u4e2a\u6570\u5b57\u63a5\u8fd1 70% \u3002<\/span><\/p>\n


<\/p>\n

\u7cbe\u795e\u533b\u751f\u5171\u540c\u4f53\u5bf9\u8fd9\u4e9b\u836f\u6beb\u65e0\u8ba4\u8bc6\uff0c\u66f4\u4e60\u60ef\u7ed9\u75c5\u4eba\u5f00\u65e7\u6709\u7684\u5b89\u5b9a\u7c7b\uff0c\u6216\u8005\u5e72\u8106\u4e0d\u5f00\u3002\u5728\u7f8e\u56fd\u4e4b\u5916\uff0c\u5927\u591a\u6570\u56fd\u5bb6\u7684\u533b\u751f\u548c\u60a3\u8005\u66f4\u662f\u5bf9\u6291\u90c1\u75c7\u8fd9\u79cd\uff08\u6216\u8005\u4e24\u79cd\uff09\u75be\u75c5\u6beb\u65e0\u8ba4\u8bc6\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u65e5\u672c\uff0c\u76f4\u5230 1989 \u5e74\uff0c\u5f53\u65f6\u6700\u5927\u7684 SSRI \u836f\u4f01\u6d3e\u4eba\u53bb\u65e5\u672c\u6253\u542c\uff0c\u5f53\u5730\u4e13\u5bb6\u8fd8\u544a\u8bc9\u5bf9\u65b9\uff0c\u65e5\u672c\u5f88\u5c11\u6709\u4eba\u5f97\u6291\u90c1\u75c7\u3002\u4e8e\u662f\u8be5\u516c\u53f8\u8ba4\u4e3a\u5e02\u573a\u592a\u5c0f\uff0c\u6253\u9053\u56de\u5e9c\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7\"<\/p>\n

\u767e\u5fe7\u89e3\uff08Prozac\uff09\u4ece\u4e0a\u5e02\u5230\u4e13\u5229\u8fc7\u671f\u7684\u9010\u5e74\u9500\u552e\u989d\u3002\u9ad8\u5cf0\u65f6\u671f\uff0c100 \u4e2a\u56fd\u5bb6\u7684\u56db\u5343\u4e07\u4eba\u5403\u767e\u5fe7\u89e3\uff0c\u5b83\u5728 2000 \u5e74\u4e3a\u793c\u6765\u516c\u53f8\u8d21\u732e\u4e86\u5f53\u5e74\u56db\u5206\u4e4b\u4e00\u7684\u6536\u5165<\/span><\/p>\n


<\/p>\n

\u9762\u5bf9\u8fd9\u79cd\u60c5\u51b5\uff0c\u845b\u5170\u7d20\u53f2\u514b\u51e0\u5927\u5382\u5546\u5f00\u59cb\u63a8\u884c\u300c\u75be\u75c5\u79d1\u666e\u300d\u3002<\/span>\u4ece 80 \u5e74\u4ee3 SSRI \u836f\u9646\u7eed\u4e0a\u5e02\u8d77\uff0c\u6709\u5173\u6291\u90c1\u75c7\u7684\u8bba\u6587\u51fa\u73b0\u4e86\u4e95\u55b7\u3002\u836f\u5382\u5e2e\u52a9\u8fd9\u4e9b\u79d1\u666e\u8bba\u6587\u4f20\u64ad\uff0c\u4e5f\u8d44\u52a9\u884c\u4e1a\u6743\u5a01\u7814\u7a76\u8fd9\u4e9b\u836f\u7269\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7\"<\/p>\n

Pubmed\u6570\u636e\u5e93\u4e2d\u6bcf\u5e74\u53d1\u8868\u7684\u5173\u4e8e\u4e34\u5e8a\u6291\u90c1\u75c7\uff08clinical depression\uff09\u7684\u8bba\u6587\u6570\u91cf<\/span><\/p>\n


<\/p>\n

\u6700\u7ec8\u533b\u751f\u548c\u60a3\u8005\u9010\u6e10\u63a5\u53d7\u300c\u6291\u90c1\u75c7\u662f\u4e00\u79cd\u751f\u7406\u75be\u75c5\u300d\u8fd9\u4e00\u6982\u5ff5\u3002<\/span><\/span>\u4e5f\u5c31\u662f\u8bf4\uff0c\u6291\u90c1\u75c7\u7684\u5e7f\u4e3a\u4eba\u77e5\u514d\u4e0d\u4e86\u793e\u4f1a\u6784\u5efa\u7684\u8fc7\u7a0b\u3002<\/span><\/p>\n


<\/p>\n

\u76f4\u5230 70 \u5e74\u4ee3\u672b\uff0c\u4f9d\u7136\u6709\u8bb8\u591a\u6587\u7ae0\u8ba4\u4e3a\u300c\u7edd\u671b\u662f\u4e34\u5e8a\u6291\u90c1\u75c7\u53d1\u751f\u7684\u4e3b\u8981\u56e0\u7d20\u300d\uff1b\u4e4b\u540e\uff0c\u968f\u7740 SSRI \u836f\u6269\u5927\u8425\u9500\uff0c\u79d1\u5b66\u5bb6\u4eec\u610f\u8bc6\u5230\u4e24\u79cd\u6291\u90c1\u75c7\u5176\u5b9e\u5c31\u662f\u540c\u4e00\u79cd\u3002\u540c\u4e00\u7c7b\u836f\u7269\u5bf9\u5b83\u4eec\u90fd\u8d77\u6548\u3002<\/span><\/p>\n


<\/p>\n

1980 \u5e74\uff0c\u5347\u7ea7\u6539\u7248\u7684\u300a\u7cbe\u795e\u75be\u75c5\u8bca\u65ad\u4e0e\u7edf\u8ba1\u624b\u518c\u300bDSM-III \u76ee\u5f55\u5c06\u4e24\u79cd\u300c\u6291\u90c1\u75c7\u300d\u5408\u5e76\u4e86\uff0c\u5bf9\u75c5\u7406\u548c\u6838\u5fc3\u75c7\u72b6\u7684\u63cf\u8ff0\u4e5f\u56f4\u7ed5\u836f\u7269\u6cbb\u7597\uff0c\u8fdb\u884c\u4e86\u91cd\u5927\u66f4\u65b0\u3002<\/span><\/p>\n


<\/p>\n

\u4eca\u5929\u4eba\u7c7b\u5bf9\u4e8e\u6291\u90c1\u75c7\u7684\u8ba4\u8bc6\uff0c\u5c31\u662f\u5728\u8fd9\u4e00\u65f6\u671f\u5960\u57fa\u7684\u3002<\/span><\/p>\n


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\u6291\u90c1\u75c7\u662f\u300c\u65f6\u4ee3\u75c5\u300d\u5417\uff1f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u968f\u7740\u795e\u7ecf\u751f\u7269\u5b66\u7684\u53d1\u5c55\uff0c\u73b0\u5728\uff0c\u5404\u79cd\u7cbe\u795e\u75be\u75c5\u90fd\u80fd\u4e0d\u540c\u7a0b\u5ea6\u5730\u627e\u5230\u751f\u7406\u5f71\u54cd\u56e0\u7d20\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5176\u5b9e\u6240\u6709\u7684\u7cbe\u795e\u75be\u75c5\u90fd\u662f\u300c\u8eab\u4f53\u75be\u75c5\u300d\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u89c2\u5ff5\u6551\u4e86\u5f88\u591a\u60a3\u8005\uff0c\u56e0\u4e3a\u7cbe\u795e\u75be\u75c5\u4e0d\u518d\u88ab\u5f52\u7ed3\u4e8e\u610f\u5fd7\u54c1\u8d28\u56e0\u7d20\uff0c\u5916\u754c\u523a\u6fc0\u4e5f\u4e0d\u662f\u5fc5\u8981\u6761\u4ef6\u3002\u5b83\u5c31\u50cf\u5934\u75bc\u4e00\u6837\uff0c\u662f\u673a\u4f53\u672c\u8eab\u7684\u95ee\u9898\uff1b\u6297\u6291\u90c1\u836f\u7269\u5c31\u50cf\u6b62\u75bc\u7247\uff0c\u4e0d\u8212\u670d\u4e86\u8be5\u7528\u5c31\u7528\u3002<\/span><\/p>\n


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\u5f53\u4eca\u4e2d\u56fd\u6291\u90c1\u75c7\u7684\u9ad8\u53d1\uff0c\u57fa\u672c\u4e0a\u662f\u8bca\u65ad\u5e26\u6765\u7684\u589e\u957f\u3002<\/span><\/strong>\u66fe\u7ecf\u7684\u300c\u795e\u7ecf\u8870\u5f31\u300d\u300c\u80f8\u95f7\u6c14\u77ed\u300d\u4ee5\u53ca\u8bb8\u591a\u7c7b\u578b\u7684\u300c\u591a\u6101\u5584\u611f\u300d\uff0c\u73b0\u5728\u90fd\u5408\u5e76\u5230\u4e86\u8fd9\u4e2a\u75be\u75c5\u4e4b\u4e2d\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u6ce2\u589e\u957f\u7684\u6d6a\u6f6e\uff0c\u53d1\u8fbe\u56fd\u5bb6\u5728\u51e0\u5341\u5e74\u524d\u5c31\u7ecf\u5386\u8fc7\u4e86\u3002\u73b0\u5728\uff0c\u4ed6\u4eec\u4f3c\u4e4e\u6b63\u5728\u8d70\u5411\u95ee\u9898\u7684\u53cd\u9762\uff1a\u8bd5\u56fe\u7528\u836f\u7269\u89e3\u51b3\u4e00\u5207\u70e6\u607c\u3002<\/span><\/p>\n


<\/p>\n

\u4e0a\u5e1d\u4fdd\u4f51\u5403\u5f97\u8d77\u836f\u7684\u4eba\u3002\u5728\u533b\u4fdd\u62a5\u9500\u7684\u6cd5\u56fd\uff0c\u5c06\u8fd1\u56db\u5206\u4e4b\u4e00\u7684\u4eba\u4f7f\u7528\u60c5\u7eea\u6539\u5584\u6027\u7684\u836f\u7269\u3002\u5728\u4ee5\u4e0d\u7231\u5f00\u836f\u8457\u79f0\u7684\u82f1\u56fd\uff0c\u56db\u767e\u4e07\u4eba\u957f\u671f\u4f7f\u7528\u6297\u6291\u90c1\u836f\u7269\uff0c\u662f\u4eba\u53e3\u7684 6% \u3002<\/span><\/p>\n


<\/p>\n

\u6bcf\u4e2a\u65f6\u523b\uff0c\u90fd\u6709 13% \u7684\u7f8e\u56fd\u4eba\u4f7f\u7528\u6297\u6291\u90c1\u836f\u7269\uff0c\u5176\u4e2d\u53ea\u6709\u4e00\u534a\u7684\u4eba\u771f\u6b63\u7b26\u5408\u4e34\u5e8a\u6291\u90c1\u75c7\u7684\u8bca\u65ad\u8981\u4ef6\u3002<\/span><\/p>\n


<\/p>\n

\u4f7f\u7528\u6297\u6291\u90c1\u836f\u7269\u4fe8\u7136\u6210\u4e86\u4e00\u79cd\u6f6e\u6d41\uff0c\u548c\u5065\u8eab\u3001\u6c99\u62c9\u3001\u590d\u5408\u679c\u6c41\u4e00\u6837\uff0c\u8c61\u5f81\u7740\u4e2d\u4ea7\u7279\u6709\u7684\u654f\u611f\u7ec6\u817b\u548c\u5bf9\u5b8c\u7f8e\u72b6\u6001\u7684\u8ffd\u6c42\u3002<\/span><\/p>\n


<\/p>\n

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<\/p>\n

WHO \u6307\u51fa\uff0c\u7ea6 80% \u7684\u5e38\u89c1\u7cbe\u795e\u969c\u788d\u53d1\u751f\u5728\u4e2d\u4f4e\u6536\u5165\u56fd\u5bb6\u30022017 \u5e74\uff0c\u4e00\u9879\u5bf9 50 \u4e07\u4e2d\u56fd\u4eba\u7684\u7814\u7a76\u663e\u793a\uff0c\u519c\u6751\u4e0e\u4f4e\u6536\u5165\u548c\u6291\u90c1\u75c7\u5448\u9ad8\u5ea6\u6b63\u76f8\u5173\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u4e0a\u6d77\uff0c\u4f53\u529b\u52b3\u52a8\u8005\u7684\u53d1\u75c5\u7387\u662f\u7ba1\u7406\u4eba\u5458\u7684 5 \u500d\u3002\u5728\u9ed4\u897f\u5357\uff0c\u6709\u5b66\u8005\u8c03\u67e5\u4e86 147 \u540d\u519c\u6751\u7559\u5b88\u8001\u4eba\uff0c\u7adf\u53d1\u73b0\u5176\u4e2d 94 \u4eba\u60a3\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u6291\u90c1\u75c7\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7a81\u7136\u5f97\u4e0a\u4e86\u6291\u90c1\u75c7\"<\/p>\n

\u6291\u90c1\u75c7\u5728\u4e2d\u4f4e\u6536\u5165\u56fd\u5bb6\u9020\u6210\u7684\u635f\u5931\uff0c\u8fdc\u5927\u4e8e\u5728\u9ad8\u6536\u5165\u56fd\u5bb6\u3002YLD\uff1a\u56e0\u4f24\u6b8b\u5bfc\u81f4\u7684\u5065\u5eb7\u751f\u547d\u5e74\u635f\u5931<\/span><\/p>\n


<\/p>\n

\u66f4\u591a\u60a3\u75c5\u7684\u5f31\u52bf\u7fa4\u4f53\u5f88\u96be\u5c06\u6291\u90c1\u75c7\u548c\u672c\u6765\u5c31\u56f0\u987f\u4e0d\u582a\u7684\u751f\u6d3b\u5206\u6e05\u3002\u4ed6\u4eec\u89e3\u51b3\u75be\u75c5\u7684\u65b9\u5f0f\u4e5f\u7b80\u5355\u7c97\u66b4\uff1a\u4e0d\u89e3\u51b3\u3002<\/span><\/p>\n


<\/p>\n

WHO \u9a7b\u534e\u4ee3\u8868\u65bd\u8d3a\u5fb7\u4f30\u7b97\uff0c\u4e2d\u56fd\u7ea6\u6709 5400 \u4e07\u6291\u90c1\u75c7\u60a3\u8005\uff0c\u53ea\u6709 20% \u63a5\u53d7\u4e86\u6cbb\u7597\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u6211\u4eec\u8eab\u8fb9\u81f3\u5c11\u6709\u56db\u5343\u4e07\u4eba\u6323\u624e\u5728\u6ce5\u6f6d\u4e2d\uff0c\u800c\u6ca1\u6709\u83b7\u5f97\u4efb\u4f55\u5e2e\u52a9\u3002<\/span><\/p>\n


<\/p>\n

\u6291\u90c1\u75c7\u7684\u6096\u8bba\u5728\u7ee7\u7eed\u3002\u79d1\u5b66\u5bb6\u7ecf\u8fc7\u51e0\u5341\u5e74\u7684\u7814\u7a76\uff0c\u624d\u78b0\u5230\u4e86\u75c5\u7406\u7684\u8fb9\u7f18\uff0c\u521b\u9020\u4e86\u6709\u6548\u7684\u836f\u7269\u3002\u7136\u800c\uff0c\u53d1\u8fbe\u56fd\u5bb6\u7684\u5bcc\u4eba\u5f00\u59cb\u8fdb\u884c\u8fc7\u5ea6\u6cbb\u7597\uff0c\u6700\u9700\u8981\u8fd9\u4e9b\u836f\u7269\u7684\u4eba\u5374\u7528\u4e0d\u4e0a\u5b83\u3002<\/span><\/p>\n


<\/p>\n

\u5b9e\u9645\u4e0a\uff0c\u6291\u90c1\u75c7\u4ece\u6765\u90fd\u4e0d\u662f\u65f6\u4ee3\u75c5\uff0c\u4e5f\u4e0d\u662f\u7cbe\u82f1\u75c5\u3002\u53ea\u662f\u7531\u4e8e\u5404\u79cd\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u4ece\u8fc7\u53bb\u5230\u4eca\u5929\uff0c\u5927\u591a\u6570\u5f97\u5b83\u7684\u4eba\u4ece\u6765\u6ca1\u6709\u673a\u4f1a\u53d1\u58f0\u800c\u5df2\u3002<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff08\u5411\u4e0b\u6eda\u52a8\uff09<\/span><\/strong><\/p>\n

1.\u79b9\u6d77\u822a, \u5d14\u9759\u9759, \u8881\u7ea2,\u7b49. \u6291\u90c1\u75c7\u4f34\u5931\u7720\u60a3\u8005\u72b6\u51b5\u8c03\u67e5[J].\u73b0\u4ee3\u5b9e\u7528\u533b\u5b66, 2012, 24(4):400-401.<\/span><\/span><\/p>\n

2. Oprea T I.Property distribution ofdrug-related chemical databases.[J]. Journal <\/span><\/p>\n

3. https:\/\/www.nature.com\/articles\/d41573-019-00014-x<\/span><\/p>\n

4. Bickerton G R,Paolini G V, Besnard J, etal. Quantifying the chemical beauty of drugs.<\/span><\/p>\n

[J].Nature Chemistry, 2012,4(2):90-98.<\/span><\/p>\n

5. Bemis G W,Murcko M A. The properties ofknown drugs. 1. Molecular frameworks.[J]. Journalof Medicinal Chemistry, 1996,39(15):2887-2893.<\/span><\/p>\n

6. Mojtabai, Ramin. “Clinician-identifieddepression in community settings: concordance with structured-interviewdiagnoses.” Psychotherapy and psychosomatics 82.3 (2013): 161-169.<\/span><\/p>\n

7.https:\/\/culture-emotion-lab.stanford.edu\/sites\/g\/files\/sbiybj9351\/f\/depressionacrossculturetsaicdryder.pdf<\/span><\/p>\n

8.https:\/\/www.huffpost.com\/entry\/antidepressant-advertising_b_1586830?utm_hp_ref=women&ir=Women&ncid=edlinkusaolp00000009<\/span><\/p>\n

9. https:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db76.pdf<\/span><\/p>\n

10. Weissman, Myrna M., and Jerome K. Myers.”Rates and risks of depressive symptoms in a United States urbancommunity.” Acta psychiatrica scandinavica 57.3 (1978): 219-231.<\/span><\/p>\n

11. American Psychiatric Association (1968).”Schizophrenia”. Diagnostic and statistical manual of mentaldisorders: DSM-II (PDF). Washington, DC: American Psychiatric Publishing, Inc<\/span><\/p>\n

12. Weissman, Myrna M. “Advances inpsychiatric epidemiology: rates and risks for major depression.” Americanjournal of public health 77.4 (1987): 445-451.<\/span><\/p>\n

13.https:\/\/www.sfgate.com\/business\/article\/Consumer-savings-expected-as-Prozac-patent-2893038.php#photo-2243126<\/span><\/p>\n

14. https:\/\/www.theguardian.com\/business\/2001\/oct\/04\/medicalscience.highereducation<\/span><\/p>\n

15. Ferrari, Alize J., et al. “Burden ofdepressive disorders by country, sex, age, and year: findings from the globalburden of disease study 2010.” PLoS medicine 10.11 (2013): e1001547.<\/span><\/p>\n

16. Kurihara, Toshiyuki, et al. “The lowprevalence of high levels of expressed emotion in Bali.” Psychiatryresearch 94.3 (2000): 229-238.<\/span><\/p>\n

17. https:\/\/www.esquire.com\/news-politics\/news\/a27628\/notes-on-an-exorcism\/<\/span><\/p>\n

18. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3330161\/ <\/span><\/p>\n

19. Schieffelin EL. The cultural analysis ofdepressive affect: An example from New Guinea. In: Kleinman AM, Good B,editors. Culture and depression: Studies in the anthropology and cross-culturalpsychiatry of affect and disorder. University of California Press; 1986. pp.101\u2013133.<\/span><\/p>\n

20. https:\/\/www.theguardian.com\/world\/2003\/nov\/08\/france.jonhenley1<\/span><\/p>\n

21. Mercier, Alain, et al. “Understandingthe prescription of antidepressants: a qualitative study among FrenchGPs.” BMC Family Practice 12.1 (2011): 99.<\/span><\/p>\n

22. \u963f\u5fb7\u91cc\u5b89\u5a1c\u00b7\u4f69\u7279\u91cc\u7eb3, \u5b89\u5fb7\u9c81\u00b7\u62c9\u79d1\u592b. \u5168\u7403\u836f\u7269:\u4f26\u7406\u3001\u5e02\u573a\u4e0e\u5b9e\u8df5[M]. \u4e0a\u6d77\u8bd1\u6587\u51fa\u7248\u793e, 2010.<\/span><\/p>\n

23. https:\/\/www.apa.org\/monitor\/2017\/11\/numbers<\/span><\/p>\n

24. \u590f\u52c7\u519b. \u7ecf\u6d4e\u53d1\u8fbe\u5730\u533a\u57fa\u5c42\u7cbe\u795e\u75c5\u533b\u9662\u4f4f\u9662\u75c5\u4eba\u60c5\u51b5\u7684\u8c03\u67e5[J]. \u4e2d\u56fd\u536b\u751f\u4e8b\u4e1a\u7ba1\u7406, 2008, 25(5):312-313.<\/span><\/p>\n

25. \u5362\u67f3\u9752. \u9996\u53d1\u6291\u90c1\u75c7\u60a3\u8005\u5e78\u798f\u6307\u6570\u548c\u793e\u4f1a\u652f\u6301\u53ca\u751f\u6d3b\u8d28\u91cf\u7684\u76f8\u5173\u6027[J]. \u62a4\u7406\u5b9e\u8df5\u4e0e\u7814\u7a76, 2017(20).<\/span><\/p>\n

26. http:\/\/www.healthdata.org\/node\/835<\/span><\/p>\n

27. https:\/\/www.thelancet.com\/gbd <\/span><\/p>\n

28.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/254610\/WHO-MSD-MER-2017.2-eng.pdf?sequence=1<\/span><\/p>\n

29. Chen, Y., et al. “Patterns andcorrelates of major depression in Chinese adults: a cross-sectional study of0.5 million men and women.” Psychological medicine 47.5 (2017): 958-970.<\/span><\/p>\n

30. \u80e1\u5065, \u96f7\u4e16\u5149. \u5174\u4e49\u5e02\u519c\u6751\u7559\u5b88\u8001\u5e74\u4eba\u6291\u90c1\u72b6\u51b5\u53ca\u76f8\u5173\u56e0\u7d20[J]. \u4e2d\u56fd\u8001\u5e74\u5b66\u6742\u5fd7, v.36(16):4081-4082.<\/span><\/p>\n

31. http:\/\/news.sohu.com\/20170407\/n486948318.shtml<\/span><\/p>\n

33. https:\/\/web.archive.org\/web\/20070820165422\/http:\/\/www.psychiatryonline.com\/DSMPDF\/dsm-ii.pdf<\/span><\/p>\n

32. https:\/\/commons.wikimedia.org\/wiki\/File:Ndeup-2.jpg<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u9996\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a\u5927\u8c61\u516c\u4f1a\uff08ID\uff1aidxgh2013\uff09\u6388\u6743\u4fee\u6539\u53d1\u5e03<\/span><\/p>\n

\u6587\u5b57\uff1a\u5f90\u5b50\u94ed<\/span><\/p>\n

\u7f16\u8f91\uff1a\u53f2\u6668\u747e<\/span><\/p>\n

\u9898\u56fe\u6765\u6e90\uff1a\u56fe\u866b\u521b\u610f<\/span><\/p>\n

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