{"id":114659,"date":"2019-06-11T12:12:49","date_gmt":"2019-06-11T04:11:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/114659\/"},"modified":"2019-06-11T12:12:01","modified_gmt":"2019-06-11T04:12:01","slug":"faef9fd012","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/114659\/","title":{"rendered":"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;letter-spacing: 0.68px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"__bg_gif\"      style=\"letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/10-1560226320.gif\" alt=\"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\" title=\"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u80bf\u7624\u65f6\u95f4\u8fd1\u671f\u5feb\u62a5\uff0c\u5e26\u7ed9\u4f60\u6700\u65b0\u7684\u8d44\u8baf\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p><strong><span style=\"color: rgb(61, 170, 214);\">\u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c<\/span><\/strong><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u963f\u7279\u73e0\u5355\u6297\u53ef\u4ee5\u6539\u5584\u7ecf\u6cbb NSCLC \u60a3\u8005\u7684\u751f\u5b58\u30025 \u6708 20 \u65e5\uff0cLancet Oncol \u516c\u5e03\u4e86 IMpower130 \u7814\u7a76\u7ed3\u679c\uff0c\u8bc4\u4f30\u963f\u7279\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u975e\u9cde NSCLC \u7684\u7597\u6548\u548c\u5b89\u5168\u6027<sup><span style=\"font-size:14px;\">[1]<\/span><\/sup>\u3002<\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u7ed3\u679c\u663e\u793a\u5728\u6ca1\u6709 ALK \u548c EGFR \u7a81\u53d8\u7684IV\u671f\u975e\u9cde NSCLC \u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u4e2d\uff0c\u963f\u7279\u73e0\u5355\u6297\u52a0\u5165\u5316\u7597\u5728 OS \u548c PFS \u4e0a\u5177\u6709\u663e\u8457\u800c\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002\u7814\u7a76\u652f\u6301\u963f\u7279\u73e0\u5355\u6297\u52a0\u5165 NSCLC \u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">IMpower130 \u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u968f\u673a\u5f00\u653e\u6807\u7b7e3\u671f\u7814\u7a76\u3002723 \u540d\u521d\u6cbb\u7684IV\u671f\u975e\u9cde NSCLC \u60a3\u8005\u968f\u673a\uff082:1\uff09\u63a5\u53d7\u963f\u7279\u73e0\u5355\u6297 1200 mg Q3W+\u5316\u7597\uff08\u5361\u94c2 AUC 6mg\/mL\u00b7min Q3W+\u767d\u86cb\u767d\u7d2b\u6749\u9187 100 mg\/m2&nbsp;QW\uff09\uff08ITT 483 \u540d\uff0c\u91ce\u751f\u578b 451 \u540d\uff09\u6216\u5355\u7eaf\u5316\u7597\uff08ITT 240 \u540d\uff0c\u91ce\u751f\u578b 228 \u540d\uff094-6 \u5468\u671f\u4e4b\u540e\u7ef4\u6301\u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f ITT \u91ce\u751f\u578b\uff08EGFR \u548c ALK\uff09\u4eba\u7fa4\u7684 PFS \u548c OS\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u4e24\u7ec4\u4e2d\u4f4d\u968f\u8bbf 18.5 \u4e2a\u6708\u548c 19.2 \u4e2a\u6708\u3002\u5728 ITT \u91ce\u751f\u578b\u4eba\u7fa4\u4e2d\uff0c\u8054\u5408\u7ec4\u7684 OS \u663e\u8457\u6539\u5584\uff0818.6 \u6708&nbsp;vs 13.9 \u6708\uff0cHR 0.79\uff0cP=0.033\uff09\uff0c\u4e2d\u4f4d PFS \u5206\u522b\u662f 7.0 \u6708&nbsp;vs 5.5 \u6708\uff08HR 0.64\uff0cP\uff1c0.0001\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u6700\u5e38\u89c1\u7684 3 \u7ea7\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u7f3a\u4e4f\uff0832% vs28%\uff09\uff0c\u8d2b\u8840\uff0829% vs20%\uff09\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0812% vs8%\uff09\u3002\u6cbb\u7597\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387 24%vs 13%\u3002\u4e24\u7ec4\u5206\u522b\u6709 8 \u540d\uff082%\uff09\u548c 1 \u540d\uff08\uff1c1%\uff09\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;letter-spacing: 0.68px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7eb3\u6b66\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u970d\u5947\u91d1\u6dcb\u5df4\u7624<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u7eb3\u6b66\u5355\u6297\u5728\u590d\u53d1\u96be\u6cbb\u6027\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u4e2d\u5177\u6709\u826f\u597d\u53cd\u5e94\u548c\u6301\u7eed\u7597\u6548\uff0c\u4f46\u662f\u5728\u521d\u6cbb cHL \u4e2d\u7684\u7597\u6548\u8fd8\u4e0d\u6e05\u695a\u3002\u8fd1\u65e5\uff0c\u8bc4\u4f30\u7eb3\u6b66\u5355\u6297+\u591a\u67d4\u6bd4\u661f\/\u957f\u6625\u82b1\u78b1\/\u8fbe\u5361\u5df4\u55ea\uff08N-AVD\uff09\u7597\u6548\u548c\u5b89\u5168\u6027\u7684CheckMate205\u7684D\u961f\u5217\u7ed3\u679c\u516c\u5e03\uff0c\u5728\u7ebf\u53d1\u8868\u5728 JCO\u4e0a<sup>[2]<\/sup><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\">N-AVD \u4e4b\u540e\u4f7f\u7528\u7eb3\u6b66\u5355\u6297\u5bf9\u4e8e\u65b0\u8bca\u65ad\u7684\u8fdb\u5c55\u671f cHL \u60a3\u8005\u5177\u6709\u826f\u597d\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(178, 178, 178);font-size: 14px;letter-spacing: 0.544px;\">51 \u540d\u8fdb\u5c55\u671f\uff08III-IV \u671f\uff0c\u4ee5\u53ca\u5177\u6709\u4e0d\u826f\u98ce\u9669\u56e0\u7d20\u7684 IIB \u671f\uff09cHL \u60a3\u8005\u63a5\u53d7 12 \u5468\u671f N-AVD \u6cbb\u7597\uff0c\u7eb3\u6b66\u5355\u6297 240 mg Q2W \u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u3002\u7597\u6548\u7ec8\u70b9\u5305\u62ec ORR \u548c PFS\uff0c\u5e76\u8bc4\u4f30\u60a3\u8005 RS \u7ec6\u80de\u7684\u67d3\u8272\u4f53 9q24.1 \u6539\u53d8\u548c PD-L1 \u8868\u8fbe\u3002<\/span><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 15px;text-align: start;widows: 2;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(178, 178, 178);font-size: 14px;letter-spacing: 0.544px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u5171 59%\u60a3\u8005\u53d1\u751f 3-4 \u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002\u6cbb\u7597\u76f8\u5173\u53d1\u70ed\u6027\u7c92\u7f3a\u53d1\u751f\u7387 10%\u3002\u5185\u5206\u6ccc\u514d\u75ab\u4ecb\u5bfc\u4e0d\u826f\u4e8b\u4ef6\u90fd\u662f 1-2 \u7ea7\uff0c\u4e0d\u9700\u8981\u5927\u5242\u91cf\u6fc0\u7d20\u6cbb\u7597\u3002\u6240\u6709\u975e\u5185\u5206\u6ccc\u514d\u75ab\u4ecb\u5bfc\u4e0d\u826f\u4e8b\u4ef6\u90fd\u53ef\u5904\u7406\uff08\u6700\u5e38\u89c1\uff0c\u76ae\u75b9\uff1b5.9%\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">ORR 84%\uff0c\u5176\u4e2d 67%\u8fbe\u5230CR\u3002\u6700\u5c0f\u968f\u8bbf 9.4 \u4e2a\u6708\uff0c9 \u4e2a\u6708\u7684\u8c03\u6574 PFS \u662f 92%\u3002PD-L1 \u9ad8\u6c34\u5e73\u7684\u60a3\u8005\u5bf9 N-AVD \u53cd\u5e94\u66f4\u597d\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u9700\u91cd\u89c6\u764c\u75c7\u60a3\u8005\u7684\u5076\u53d1\u80ba\u6813\u585e<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u7ea6 5%\u764c\u75c7\u60a3\u8005\u5728\u5e38\u89c4\u5f71\u50cf\u5b66\u68c0\u67e5\u65f6\u53d1\u73b0\u5076\u53d1\u6027\u80ba\u6813\u585e\uff0c\u5176\u4e34\u5e8a\u610f\u4e49\u548c\u6700\u4f73\u6cbb\u7597\u8fd8\u4e0d\u6e05\u695a\u3002JCO \u4e8e 5\u6708 22 \u65e5\u53d1\u8868\u7814\u7a76\uff0c\u8bc4\u4f30\u4e86\u764c\u75c7\u60a3\u8005\u5076\u53d1\u80ba\u6813\u585e\u7684\u6cbb\u7597\u7b56\u7565\u548c\u957f\u671f\u4e34\u5e8a\u7ed3\u5c40<sup><span style=\"font-size:14px;\">[3]<\/span><\/sup>\u3002<\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u5076\u53d1\u80ba\u6813\u585e\u7684\u764c\u75c7\u60a3\u8005\u5373\u4fbf\u4f7f\u7528\u6297\u51dd\u6cbb\u7597\uff0c\u590d\u53d1\u6027\u9759\u8109\u8840\u6813\u6813\u585e\uff08VTE\uff09\u7684\u98ce\u9669\u4f9d\u65e7\u663e\u8457\uff0c\u4e14\u4e9a\u6bb5\u80ba\u6813\u585e\u548c\u8fd1\u7aef\u80ba\u6813\u585e\u7684\u590d\u53d1\u6027VTE\u98ce\u9669\u4f3c\u4e4e\u8fd1\u4f3c\uff0c\u503c\u5f97\u5f15\u8d77\u91cd\u89c6\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;text-align: start;widows: 2;color: rgb(63, 63, 63);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(178, 178, 178);font-size: 14px;letter-spacing: 0.544px;widows: 1;text-align: justify;\">\u8fd9\u662f\u4e00\u9879\u56fd\u9645\u524d\u77bb\u6027\u89c2\u5bdf\u961f\u5217\u7814\u7a76\u3002\u7eb3\u5165 695 \u540d\u8fd1\u671f\u8bca\u65ad\u5076\u53d1\u80ba\u6813\u585e\u7684\u6d3b\u8dc3\u764c\u75c7\u60a3\u8005\u3002\u7ed3\u5c40\u662f 12 \u4e2a\u6708\u968f\u8bbf\u671f\u7684\u590d\u53d1\u6027 VTE\uff0c\u5927\u51fa\u8840\u548c\u5168\u56e0\u6b7b\u4ea1\u7387\u3002<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;text-align: start;widows: 2;color: rgb(63, 63, 63);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(178, 178, 178);font-size: 14px;letter-spacing: 0.544px;widows: 1;text-align: justify;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u6700\u5e38\u89c1\u7684\u764c\u75c7\u7c7b\u578b\u662f\u7ed3\u76f4\u80a0\u764c\uff0821%\uff09\u548c\u80ba\u764c\uff0815%\uff09\u3002675 \u540d\u60a3\u8005\uff0897%\uff09\u8fdb\u884c\u6297\u51dd\u6cbb\u7597\uff0c\u5176\u4e2d 600 \u540d\uff0889%\uff09\u4f7f\u7528\u4f4e\u5206\u5b50\u809d\u7d20\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">41 \u540d\u60a3\u8005\u53d1\u751f\u590d\u53d1VTE\uff0812 \u4e2a\u6708\u7d2f\u79ef\u53d1\u751f\u73876.0%\uff09\uff0c39 \u540d\u53d1\u751f\u5927\u51fa\u8840\uff0812 \u4e2a\u6708\u7d2f\u79ef\u53d1\u751f\u7387 5.7%\uff09\uff0c283 \u540d\u60a3\u8005\u6b7b\u4ea1\uff0812 \u4e2a\u6708\u7d2f\u79ef\u53d1\u751f\u7387 43%\uff09\u3002\u4e9a\u6bb5\u80ba\u6813\u585e\u60a3\u8005\u7684 12 \u4e2a\u6708\u590d\u53d1\u6027 VTE \u53d1\u751f\u7387 6.4%\uff0c\u800c\u8fd1\u7aef\u80ba\u6813\u585e\u53d1\u751f\u7387 6.0%\uff08HR 1.1\uff0cP=0.93\uff09\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u6297\u759f\u836f\u6cbb\u7597\u80f0\u817a\u764c\uff1f<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;letter-spacing: 0.68px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u81ea\u566c\u662f\u80f0\u817a\u764c\u5316\u7597\u7684\u8010\u836f\u673a\u5236\uff0c\u6297\u759f\u836f\u6c2f\u55b9\uff08HCQ\uff09\u4e5f\u662f\u4e00\u79cd\u81ea\u566c\u6291\u5236\u5242\uff0c\u6709\u53ef\u80fd\u5177\u6709\u6297\u764c\u4f5c\u7528\u3002HCQ \u8054\u5408\u5316\u7597\u6cbb\u7597\u665a\u671f\u80f0\u817a\u764c\u7684 2 \u671f\u7814\u7a76\u7ed3\u679c\u516c\u5e03\uff0c\u4e8e 5 \u6708 23 \u65e5\u53d1\u8868\u5728 JAMA Oncol \u4e0a<sup>[4]<\/sup><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\">\u7814\u7a76\u672a\u8fbe\u5230\u9996\u8981\u7ec8\u70b9\uff0cHCQ \u4e0d\u80fd\u6539\u5584\u80f0\u817a\u764c\u751f\u5b58\uff0c\u6570\u636e\u4e0d\u652f\u6301\u5316\u7597+HCQ \u5728\u6ca1\u6709\u751f\u7269\u6807\u5fd7\u7269\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u4e2d\u7684\u5e38\u89c4\u5e94\u7528\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;text-align: start;widows: 2;color: rgb(63, 63, 63);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(178, 178, 178);font-size: 14px;letter-spacing: 0.544px;widows: 1;text-align: justify;\">\u4e3a\u4e86\u660e\u786e\u6c2f\u55b9\u8054\u5408\u5409\u897f\u4ed6\u6ee8+\u767d\u86cb\u767d\u7d2b\u6749\u9187\uff08GA\uff09\u662f\u5426\u53ef\u4ee5\u6539\u5584\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u7684\u751f\u5b58\uff0c\u884c\u6b64 2 \u671f\u968f\u673a\u7814\u7a76\u3002\u7eb3\u5165 112 \u540d\u521d\u6cbb\u7684\u8f6c\u79fb\u6216\u8fdb\u5c55\u671f\u80f0\u817a\u764c\u60a3\u8005\uff0c\u968f\u673a\uff081:1\uff09\u63a5\u53d7\u6807\u51c6\u5242\u91cf GA+HCQ 600 mg Bid\uff08n=55\uff09\u6216 GA\uff08n=57\uff09\u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f 1 \u5e74\u751f\u5b58\u7387\u3002<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u4e24\u7ec4\u7684 12 \u4e2a\u6708 OS \u7387\u5206\u522b\u662f 41% vs 49%\uff0c\u4e2d\u4f4d PFS \u5206\u522b\u662f 5.7 \u6708&nbsp;vs 6.4 \u6708\uff0c\u4e2d\u4f4d OS \u5206\u522b\u662f 11.1 \u6708&nbsp;vs 12.1 \u6708\u3002ORR \u5206\u522b\u662f 38.2% vs 21.1%\uff08P=0.047\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u4e24\u7ec4\u6709\u5dee\u5f02\u7684\u6cbb\u7597\u76f8\u5173 3-4 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0842.6% vs 22.6%\uff09\uff0c\u8d2b\u8840\uff083.7% vs 17.0%\uff09\uff0c\u4e4f\u529b\uff087.4% vs 0\uff09\uff0c\u6076\u5fc3\uff089.3% vs 0\uff09\uff0c\u5916\u5468\u795e\u7ecf\u75c5\uff0813.0% vs 5.7%\uff09\uff0c\u89c6\u529b\u6539\u53d8\uff085.6% vs 0\uff09\u548c\u795e\u7ecf\u7cbe\u795e\u75c5\u75c7\u72b6\uff085.6% vs 0\uff09\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">PD-1\/L-1 \u6297\u4f53\u7684\u4e0d\u826f\u4e8b\u4ef6\u5173\u8054\u7ed3\u5c40<\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">\u5df2\u7ecf\u6709\u8bc1\u636e\u8868\u660e\u514d\u75ab\u6cbb\u7597\u7684\u4e0d\u826f\u4e8b\u4ef6\u53ef\u80fd\u548c\u60a3\u8005\u7684\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u30025 \u6708 22 \u65e5\uff0cJCO \u518d\u6b21\u520a\u767b\u7814\u7a76\uff0c\u8bc4\u4f30\u4e86\u63a5\u53d7 PD-1\/L-1 \u6297\u4f53\u6cbb\u7597\u7684\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e0d\u826f\u4e8b\u4ef6\u548c\u7597\u6548\u7684\u5173\u7cfb<sup>[5]<\/sup><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\">\u6c47\u603b 7 \u9879\u7814\u7a76\u30011747 \u540d\u60a3\u8005\u7684\u6570\u636e\u5206\u6790\u8868\u660e\uff0c\u5bf9\u6297 PD-1\/L1 \u836f\u7269\u6709\u53cd\u5e94\u7684\u60a3\u8005\u66f4\u53ef\u80fd\u53d1\u751f\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e14\u8fd9\u79cd\u5173\u7cfb\u4f3c\u4e4e\u4e0d\u662f\u7531\u4e8e\u53cd\u5e94\u60a3\u8005\u7684\u66b4\u9732\u6301\u7eed\u65f6\u95f4\u5ef6\u957f\u5f15\u8d77\u3002\u5168\u8eab\u6fc0\u7d20\u7684\u4f7f\u7528\u4e0d\u5f71\u54cd\u6cbb\u7597\u53cd\u5e94\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u4e3a\u8bc4\u4f30\u80bf\u7624 ORR\uff0cOS \u548c\u76f8\u5173\u7279\u6b8a\u4e0d\u826f\u4e8b\u4ef6\uff08AESIs\uff09\u6216\u76f8\u5173\u514d\u75ab\u4ecb\u5bfc\u4e0d\u826f\u4e8b\u4ef6\uff08imAEs\uff09\u7684\u5173\u7cfb\uff0c\u63a2\u7d22\u6027\u5206\u6790 7 \u4e2a\u7814\u7a76\u30011747 \u540d\u63a5\u53d7\u6297 PD-1\/ L1 \u6cbb\u7597\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\uff0c\u641c\u7d22 AESIs \u548c imAEs \u6570\u636e\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">64%\u7684\u53cd\u5e94\u60a3\u8005\u548c 34%\u7684\u65e0\u53cd\u5e94\u60a3\u8005\u53d1\u751f\u76f8\u5173 AESI\uff0c\u800c 28%\u7684\u53cd\u5e94\u60a3\u8005\u548c 12%\u7684\u65e0\u53cd\u5e94\u60a3\u8005\u53d1\u751f\u76f8\u5173 imAE\u3002\u5206\u6790\u5bf9\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u60a3\u8005\uff0c\u5177\u6709\u76f8\u5173 AESIs \u7684\u60a3\u8005\u6bd4\u6ca1\u6709\u76f8\u5173 AESIs \u7684\u60a3\u8005 OS \u6709\u6240\u589e\u52a0\uff08HR 0.45\uff09\u3002\u5177\u6709\u76f8\u5173 AESI \u7684\u60a3\u8005 57%\u4e2d\u5728\u836f\u7269\u53cd\u5e94\u524d\u5c31\u6c47\u62a5 AESI\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;transform: translate3d(0px, 0px, 0px);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.7px;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 0.7px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u6295\u7a3f\uff1adecie@qq.com<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u9898\u56fe\uff1a<span style=\"max-width: 100%;letter-spacing: 0.544px;text-align: left;\">\u7ad9\u9177\u6d77\u6d1bplus<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n<h2 class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283901&amp;idx=2&amp;sn=4fcc6adcbf1bfb23022447ebaa946054&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/a><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283901&amp;idx=2&amp;sn=4fcc6adcbf1bfb23022447ebaa946054&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">3 \u4e2a\u75c5\u4f8b\u6559\u4f60\u641e\u5b9a\u764c\u75c7\u76f8\u5173\u9759\u8109\u8840\u6813\u6813\u585e<\/a><\/h2>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(84, 84, 84);letter-spacing: 0.68px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283749&amp;idx=1&amp;sn=d2f38c86ef6387a4f76831f24a629a38&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 17px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u518d\u5582\u517b\u7efc\u5408\u5f81\uff1a<\/span><\/a><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283749&amp;idx=1&amp;sn=d2f38c86ef6387a4f76831f24a629a38&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8425\u517b\u8865\u5145\u4e0d\u80fd\u64cd\u4e4b\u8fc7\u6025<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(84, 84, 84);line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283788&amp;idx=1&amp;sn=a386b55a7981f5ff8b16db80be6b9385&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u53c8\u6709\u65b0\u65b9\u6848<\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(84, 84, 84);line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283728&amp;idx=1&amp;sn=cf5cb89f3b41f3affcbad8211d487ae6&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u4e73\u817a\u764c 21 \u57fa\u56e0\u68c0\u6d4b\u7684\u90a3\u4e9b\u4e8b<\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages __bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/9-1560226321.gif\" alt=\"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\" title=\"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;transform: translate3d(0px, 0px, 0px);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;font-size: 14px;letter-spacing: 0.7px;line-height: 1.9;color: rgb(160, 160, 160);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"\"          style=\"font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 657px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/4-1560226321.png\" alt=\"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\" title=\"\u80bf\u7624\u5feb\u62a5 | \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c\"  \/><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p style=\"margin-bottom:10px;line-height:130%;\">1. West H et al. Atezolizumab in combination with carboplatin plusnab-paclitaxel chemotherapy compared with chemotherapy alone as first-linetreatment for metastatic non-squamous non-small-cell lung cancer (IMpower130):a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 2019 May 20<\/p>\n<p style=\"margin-bottom:10px;line-height:130%;\">2. Ramchandren R et al. Nivolumab for Newly DiagnosedAdvanced-Stage Classic Hodgkin Lymphoma: Safety and Efficacy in the Phase IICheckMate 205 Study. J Clin Oncol 2019 May 21<\/p>\n<p style=\"margin-bottom:10px;line-height:130%;\">3. Kraaijpoel N et al. Treatment and Long-Term Clinical Outcomes ofIncidental Pulmonary Embolism in Patients With Cancer: An InternationalProspective Cohort Study. J Clin Oncol 2019 May 22<\/p>\n<p style=\"margin-bottom:10px;line-height:130%;\">4. Karasic TB et al. Effect of Gemcitabine and nab-Paclitaxel Withor Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: APhase 2 Randomized Clinical Trial. JAMA Oncol 2019 May 23<\/p>\n<p style=\"margin-bottom:10px;line-height:130%;\">5. Maher VE et al. Analysis of the Association Between AdverseEvents and Outcome in Patients Receiving a Programmed Death Protein 1 orProgrammed Death Ligand 1 Antibody. J Clin Oncol 2019 May 22<\/p>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80bf\u7624\u65f6\u95f4\u8fd1\u671f\u5feb\u62a5\uff0c\u5e26\u7ed9\u4f60\u6700\u65b0\u7684\u8d44\u8baf\u3002 \u963f\u7279\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u80ba\u764c \u963f\u7279\u73e0\u5355\u6297\u53ef\u4ee5\u6539\u5584\u7ecf\u6cbb NSCLC \u60a3\u8005\u7684\u751f\u5b58\u3002 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":114660,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114659"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=114659"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114659\/revisions"}],"predecessor-version":[{"id":114664,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114659\/revisions\/114664"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/114660"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=114659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=114659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=114659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}