{"id":114716,"date":"2019-06-11T12:13:21","date_gmt":"2019-06-11T04:12:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/114716\/"},"modified":"2019-06-11T12:12:33","modified_gmt":"2019-06-11T04:12:33","slug":"0f56524ad7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/114716\/","title":{"rendered":"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<p>&nbsp; &nbsp; &nbsp; &nbsp;<\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/4-1560226352.gif\" alt=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\" title=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\"  \/><\/p>\n<section class=\"_135editor\"   >\n<section class=\"layout\" style=\"margin:10px auto;\">\n<section style=\"width:100%;margin-bottom: -30px;text-align:center;\" >\n<section style=\"width: 64px;height: 64px;background: rgb(254, 254, 254);border-radius: 50%;margin-right: auto;margin-left: auto;display: inline-block;box-sizing: border-box;\">\n<section  style=\"display:inline-block;width:32px;\"><img loading=\"lazy\" border=\"0\" class=\"assistant\"     height=\"\" style=\"margin-top: 18px;width: 32px !important;\" title=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\" width=\"2rem\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/10-1560226352.png\" alt=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\"  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 14px;color: #ffffff;padding: 30px;background-color: #3daad6;border-radius: 10px;margin-top: -16px;\"><span style=\"font-size: 17px;\">\u6211\u4eec\u9700\u8981\u4ee5 PARP \u6291\u5236\u5242\u5355\u836f\u7684\u6210\u529f\u4e3a\u57fa\u7840\uff0c\u5bfb\u627e\u4e0d\u540c\u80bf\u7624\u548c\u4e0d\u540c\u5206\u5b50\u4e9a\u578b\u4e2d\uff0c\u73b0\u6709\u9002\u5e94\u8bc1\u4e4b\u5916\u7684\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"font-size: 14px;color: #ffffff;padding: 30px;background-color: #3daad6;border-radius: 10px;margin-top: -16px;text-align: right;\"><span style=\"font-size: 17px;\">&nbsp;&nbsp;<\/span><span style=\"font-size: 16px;\">&nbsp;\u2014\u2014\u4e13\u9898\u4e3b\u5e2d\uff0c\u5fb7\u5dde\u5927\u5b66 MD \u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3 Timothy A. Yap \u535a\u58eb&nbsp;<\/span><\/p>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\">DNA\u635f\u4f24\u53cd\u5e94\uff08DNA damage response\uff0cDDR\uff09\u9632\u5fa1\u673a\u5236\u662f\u7ef4\u62a4\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u7684\u91cd\u8981\u9014\u5f84\uff0cDDR\u7f3a\u9677\u53ef\u5bfc\u81f4\u5305\u62ec\u80bf\u7624\u5728\u5185\u7684\u591a\u79cd\u75be\u75c5\u7684\u53d1\u751f\uff0cDDR\u901a\u8def\u5df2\u7ecf\u6210\u4e3a\u6297\u80bf\u7624\u836f\u7269\u9776\u70b9\uff0c\u5176\u4e2d\u6700\u7a81\u51fa\u7684\u836f\u7269\u5c31\u662fPARP\u6291\u5236\u5242\u3002<\/p>\n<p class=\"p1\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u8be5\u9886\u57df\u5145\u6ee1\u524d\u9014\uff0c\u4f46\u8fd9\u4e9b\u5e74\u6765\u7f3a\u4e4f\u5207\u5b9e\u7684\u8fdb\u5c55\u30025 \u6708 31 \u65e5\uff0cASCO \u4e3e\u884c\u4e86\u6559\u80b2\u4e13\u9898\u2014\u2014\u300cDDR\uff1aDNA \u635f\u4f24\u9769\u547d\u300d\u3002<br  \/><\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: center;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: rgb(61, 170, 214);text-decoration: underline;font-size: 18px;\"><strong>&nbsp;\u6cbb\u7597\u73b0\u72b6&nbsp;<\/strong><\/span><\/p>\n<p style=\"text-align: center;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: rgb(61, 170, 214);\"><strong>\uff08\u82f1\u56fd\u5317\u65b9\u764c\u75c7\u4e2d\u5fc3 Elizabeth R. Plummer \u535a\u58eb\uff09<\/strong><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">PARP \u5bb6\u65cf\u5177\u6709 17 \u4e2a\u6210\u5458\uff0c\u4f46\u53ea\u6709 PARP-1 \u548c PARP-2 \u53ef\u4ee5\u88ab DNA \u65ad\u88c2\u6d3b\u5316\u5e76\u5bf9\u5176\u8fdb\u884c\u4fee\u590d\u3002\u5728\u6d3b\u8dc3\u5206\u88c2\u7684\u764c\u75c7\u7ec6\u80de\u4e2d\u963b\u65ad PARP \u53ef\u4ee5\u5bfc\u81f4 DNA \u7684\u53cc\u94fe\u65ad\u88c2\uff0c\u5982\u679c\u5b58\u5728 BRCA1\/2 \u7a81\u53d8\u4e4b\u7c7b\u7684\u7f3a\u9677\uff0c\u53cc\u94fe\u65ad\u88c2\u5c31\u65e0\u6cd5\u4fee\u590d\uff0c\u56e0\u800c\u5bf9\u4e8e PARP \u6291\u5236\u5242\u5355\u836f\u654f\u611f\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><strong><span style=\"color: #7F7F7F;\">\u5df2\u7ecf\u6709\u8d85\u8fc7 10 \u79cd PARP \u6291\u5236\u5242\u8fdb\u884c\u4e86\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d 4 \u79cd\u83b7\u6279\u3002<\/span><\/strong><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u5375\u5de2\u764c\u60a3\u8005\u5bf9\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u6cbb\u7597\u53cd\u5e94\u540e\uff0c\u63a8\u8350\u4f7f\u7528 PARP \u6291\u5236\u5242\u7ef4\u6301\u6cbb\u7597\u3002SOLO1 \u7814\u7a76\u4e5f\u8868\u660e BRCA \u7a81\u53d8\u80bf\u7624\u4e2d\uff0c\u65e0\u8bba\u4e00\u7ebf\u94c2\u7c7b\u5316\u7597\u540e\u53cd\u5e94\u5982\u4f55\uff0c\u5965\u62c9\u5e15\u5c3c\u7ef4\u6301\u6cbb\u7597\u90fd\u6709\u83b7\u76ca\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<\/li>\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u53d1\u8868\u4e8e 2018 \u5e74\u7684 OlympiAD \u548c EMBRACA \u7814\u7a76\u8868\u660e\uff0c\u5728 BRCA \u7a81\u53d8\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u4e2d\uff0c\u5965\u62c9\u5e15\u5c3c\u548c talazoparib \u4e0e\u5355\u836f\u5316\u7597\u76f8\u6bd4\u90fd\u5177\u6709 PFS \u4f18\u52bf\uff0c\u4f46\u662f\u4f18\u52bf\u4ec5\u6709 3 \u4e2a\u6708\uff0c\u800c\u4e14\u7f3a\u4e4f OS \u4f18\u52bf\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<\/li>\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">PARP \u6291\u5236\u5242\u6700\u6709\u524d\u9014\u7684\u65b9\u5411\u53ef\u80fd\u662f\u524d\u5217\u817a\u764c\uff0c\u7279\u522b\u662f BRCA \u6216\u5176\u4ed6 DDR \u7a81\u53d8\u7684\u80bf\u7624\u3002TRITON2 \u548c TOPARP \u7814\u7a76\u5df2\u7ecf\u663e\u793a\u4e86 rucaparib \u548c\u5965\u62c9\u5e15\u5c3c\u7684\u6d3b\u6027\u3002<\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<\/li>\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u6b64\u5916\uff0c\u5965\u62c9\u5e15\u5c3c\u5728 BRCA \u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u4e2d\u7684 III \u671f\u7814\u7a76\u4e5f\u4f1a\u5728 ASCO \u5168\u4f53\u4f1a\u8bae\u4e2d\u516c\u5e03\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: center;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"text-decoration: underline;color: rgb(61, 170, 214);\"><strong><span style=\"text-decoration: underline;font-size: 18px;\">&nbsp;\u5408\u7406\u8054\u5408&nbsp;<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: #3DAAD6;\"><strong>\uff08\u5fb7\u5dde\u5927\u5b66 MD \u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3 Timothy A. Yap \u535a\u58eb\uff09<\/strong><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u8054\u5408\u6cbb\u7597\u7684\u6700\u5927\u56f0\u96be\u5728\u4e8e\u6bd2\u6027\u7684\u91cd\u53e0\uff0c\u4e3a\u51cf\u5c0f\u6bd2\u6027\u4f1a\u5bfc\u81f4\u6cbb\u7597\u5242\u91cf\u4e0d\u8db3\u3002\u4f46\u662f\uff0c\u4e0d\u662f\u6240\u6709 BRCA1\/2 \u7a81\u53d8\u7684\u60a3\u8005\u90fd\u5bf9\u6709\u53cd\u5e94\uff0c\u800c\u4e14\u8010\u836f\u4e5f\u51e0\u4e4e\u65e0\u6cd5\u907f\u514d\uff0c\u56e0\u6b64\u4f9d\u65e7\u9700\u8981\u5408\u7406\u7684\u8054\u5408\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u65e9\u671f\u7814\u7a76\u4e2d\u5316\u7597\u836f\u662f\u8054\u5408\u7814\u7a76\u7684\u57fa\u7840\uff0c\u73b0\u5728\u5219\u66f4\u591a\u96c6\u4e2d\u4e8e VEGFR \u6291\u5236\u5242\uff0c\u5305\u62ec ATR \u6291\u5236\u5242\u5728\u5185\u7684 DDR \u7279\u5f02\u6027\u836f\u7269\u7b49\u9776\u5411\u836f\u7269\uff0c\u4ee5\u53ca\u514d\u75ab\u836f\u7269 PD-1\/PD-L1 \u6291\u5236\u5242\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">mTOR \u6291\u5236\u5242\uff0cPI3K \u6291\u5236\u5242\u7b49\u5206\u5b50\u9776\u5411\u836f\u7269\u53ef\u4ee5\u901a\u8fc7\u8bf1\u5bfc HR \u6b63\u5e38\u80bf\u7624\u7684 HRD \u8868\u578b\uff0c\u521b\u9020\u51fa\u4e00\u79cd<span style=\"color: #3DAAD6;\"><strong>\u300c\u5316\u5b66 BRCA \u72b6\u6001\u300d<\/strong><\/span>\u3002\u8054\u5408\u897f\u5730\u5c3c\u5e03\u548c\u5965\u62c9\u5e15\u5c3c\uff0c\u53f8\u7f8e\u66ff\u5c3c\u548c\u5965\u62c9\u5e15\u5c3c\uff0calpelisib \u548c\u5965\u62c9\u5e15\u5c3c\uff0c\u4ee5\u53ca\u963f\u6bd4\u7279\u9f99\u548c\u5965\u62c9\u5e15\u5c3c\u7684\u7814\u7a76\u90fd\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u7406\u8bba\u4e0a\u8bf4\uff0c\u8054\u5408 PARP \u6291\u5236\u5242\u548c\u5176\u4ed6 DDR \u901a\u8def\u9776\u5411\u836f\u7269\uff0c\u7279\u522b\u662f ATR \u6291\u5236\u5242\u4e5f\u662f\u4e00\u79cd\u5408\u7406\u7b56\u7565\u3002PARP \u6291\u5236\u5242\u5bfc\u81f4 DNA \u52a0\u5408\u7269\u589e\u52a0\uff0c\u8fdb\u800c\u963b\u788d\u590d\u5236\u53c9\u7684\u5f62\u6210\uff1b\u4fee\u590d\u8fd9\u79cd\u963b\u788d\u7684\u590d\u5236\u53c9\u9700\u8981 ATR\uff0c\u56e0\u800c\u8054\u5408\u6291\u5236\u53ef\u4ee5\u5bfc\u81f4 DNA \u635f\u4f24\u548c\u7ec6\u80de\u6b7b\u4ea1\u589e\u52a0\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u4e00\u9879\u5728\u591a\u79cd\u80bf\u7624\u60a3\u8005\u4e2d\u8054\u5408 ATR \u6291\u5236\u5242 AZD6738 \u548c\u5965\u62c9\u5e15\u5c3c\u7684 I \u671f\u7814\u7a76\u663e\u73b0\u51fa\u4e86\u826f\u597d\u7ed3\u679c\uff0c\u4f46\u53cd\u5e94\u7684\u60a3\u8005\u90fd\u5177\u6709 BRCA \u76f8\u5173\u80bf\u7624\uff0c\u7597\u6548\u662f\u5426\u836f\u7269\u534f\u540c\u5bfc\u81f4\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u800c PARP \u6291\u5236\u5242\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u8054\u5408\u4f3c\u4e4e\u4e5f\u5e76\u4e0d\u662f\u5168\u65e0\u9053\u7406\u3002PARP \u6291\u5236\u5bfc\u81f4\u7684 DNA \u635f\u4f24\u4f7f\u5f97\u65b0\u6297\u539f\u8868\u8fbe\u589e\u52a0\uff0c\u610f\u5473\u7740\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u80fd\u6709\u6548\u3002<\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u5728 BRCA1\/2 \u7a81\u53d8\u5375\u5de2\u764c\u4e2d\u8054\u5408\u5965\u62c9\u5e15\u5c3c\u548c durvalumab\uff0c\u4ee5\u53ca\u5c3c\u62c9\u5e15\u5c3c\u8054\u5408\u5e15\u59c6\u5355\u6297\u6cbb\u7597\u94c2\u7c7b\u8010\u836f\u5375\u5de2\u764c\u7684\u65e9\u671f\u7814\u7a76\u5df2\u7ecf\u770b\u5230\u826f\u597d\u7ed3\u679c\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: #3DAAD6;\">\u4f46\u662f\u6211\u4eec\u4e5f\u8981\u770b\u5230\u8054\u5408\u7684\u6bd2\u6027\u95ee\u9898\u3002<\/span>\u4f3c\u4e4e\u53ea\u6709 PD-1\/PD-L1 \u8054\u5408\u5177\u6709\u4e0d\u91cd\u53e0\u6bd2\u6027\u3002\u514b\u670d\u6bd2\u6027\u7684\u7b56\u7565\u5305\u62ec\u66f4\u597d\u7684\u652f\u6301\u65b9\u6cd5\uff0c\u836f\u7269\u5047\u671f\uff0c\u548c\u521b\u9020\u6027\u7684\u836f\u7269\u4f7f\u7528\u65f6\u673a\uff0c\u5e76\u9700\u8981\u66f4\u597d\u7684\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u5728\u8bbe\u8ba1\u65b0\u836f\u65f6\u63d0\u524d\u8003\u8651\u5230\u836f\u7269\u6bd2\u6027\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: center;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: rgb(61, 170, 214);font-size: 18px;text-decoration: underline;\"><strong>&nbsp;\u5176\u4ed6\u65b0\u836f&nbsp;<\/strong><\/span><\/p>\n<p style=\"text-align: center;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: #3DAAD6;\"><strong>\uff08\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u6089\u5c3c\u91d1\u6885\u5c14\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3 Nilofer S. Azad \u535a\u58eb\uff09<\/strong><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u4ee5 ATR\uff0cWEE1\uff0cCHK1\/2 \u7b49\u4e3a\u9776\u70b9\u7684\u65b0\u578b DNA \u635f\u4f24\u53cd\u5e94\u8c03\u8282\u5242\u7684\u7814\u7a76\u4e5f\u5728\u8fdb\u884c\u3002\u4f46\u7531\u4e8e\u836f\u7269\u6bd2\u6027\u548c\u60a3\u8005\u9009\u62e9\u95ee\u9898\uff0c\u6240\u6709\u8fd9\u4e9b\u836f\u7269\u90fd\u56f0\u5728\u4e86\u65e9\u671f\u7814\u7a76\u9636\u6bb5\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u6700\u8fd1\u51fa\u73b0\u4e86\u4e00\u4e9b\u6709\u5e0c\u671b\u7684\u7ed3\u679c\u3002<\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u4e00\u9879 II \u671f\u7814\u7a76\u53d1\u73b0\u4e00\u79cd CHK1\/2 \u6291\u5236\u5242 prexasertib \u5728 BRCA \u91ce\u751f\u578b\u590d\u53d1\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u5375\u5de2\u764c\u4e2d\u5177\u6709\u826f\u597d\u6d3b\u6027\uff0c28 \u540d\u60a3\u8005\u4e2d 8 \u540d\u6709\u53cd\u5e94\uff0c\u4f46 4 \u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u53d1\u751f\u7387\u5f88\u9ad8\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u6b64\u5916\uff0c\u5305\u62ec\u4ee5 POLE \u901a\u8def\uff0c MTHFD2 \u86cb\u767d\u4e3a\u9776\u70b9\u7684\u836f\u7269\u6b63\u5728\u5f00\u53d1\u4e2d\u3002\u524d\u8def\u6f2b\u6f2b\uff0c\u5374\u4e5f\u5145\u6ee1\u5e0c\u671b\u3002\u9700\u8981\u7ee7\u7eed\u7814\u7a76\u5982\u4f55\u7b56\u7565\u6027\u8054\u5408\u8fd9\u4e9b\u836f\u7269\u4ee5\u8fbe\u5230\u4f4e\u6bd2\u9ad8\u6548\u3002<\/p>\n<p style=\"text-align: start;white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"color: rgb(0, 0, 0);text-align: start;white-space: normal;line-height: 1.5;font-size: 17px;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"width:100%;text-align:center;\" ><img class=\"\"     style=\"width: 70px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/1-1560226352.gif\" alt=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\" title=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\"  \/><\/section>\n<\/section>\n<p class=\"p1\"><br  \/><\/p>\n<p class=\"p1\" style=\"text-align: center;\"><span style=\"color: #7F7F7F;\">\u6301\u7eed\u5173\u6ce8 ASCO\uff0c\u6211\u4eec\u6709\u66f4\u591a\u8d44\u8baf\u3002<\/span><\/p>\n<p class=\"p1\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/10-1560226353.jpeg\" alt=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\" title=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\"  \/><\/p>\n<p><br  \/><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.7px;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 0.7px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6295\u7a3f\uff1adecie@qq.com<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9898\u56fe\uff1aASCO annual 2019<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n<p class=\"p1\"><span style=\"font-size: 16px;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284127&amp;idx=1&amp;sn=20d004b9ed50ecdff49e7483ca10f9c9&amp;scene=21#wechat_redirect\" target=\"_blank\" >ASCO&nbsp;| \u4e2d\u56fd\u5b66\u8005\u62a5\u9053\u9f3b\u54bd\u764c\u6cbb\u7597\u65b0\u65b9\u6848<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(84, 84, 84);text-align: left;line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283788&amp;idx=1&amp;sn=a386b55a7981f5ff8b16db80be6b9385&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u53c8\u6709\u65b0\u65b9\u6848<\/a><\/p>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284115&amp;idx=1&amp;sn=024024fecea1d3dca612f4f8c62f907c&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7531\u591a\u5230\u5c11\uff1a\u4e73\u817a\u764c\u524d\u54e8\u6d3b\u68c0\u5e94\u8be5\u5982\u4f55\u5e94\u7528\uff1f<\/a><\/span><\/p>\n<p><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/3-1560226353.gif\" alt=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\" title=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/9-1560226353.png\" alt=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\" title=\"ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d\"  \/><\/p>\n<p><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u53c2\u8003\uff1a<\/span><\/p>\n<p class=\"p1\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">https:\/\/dailynews.ascopubs.org\/do\/10.1200\/ADN.19.190298\/full<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; &nbsp; &nbsp; \u6211\u4eec\u9700\u8981\u4ee5 PARP \u6291\u5236\u5242\u5355\u836f\u7684\u6210\u529f\u4e3a\u57fa\u7840\uff0c\u5bfb\u627e\u4e0d\u540c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":114717,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114716"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=114716"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114716\/revisions"}],"predecessor-version":[{"id":114724,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114716\/revisions\/114724"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/114717"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=114716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=114716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=114716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}