{"id":114725,"date":"2019-06-11T12:13:25","date_gmt":"2019-06-11T04:12:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/114725\/"},"modified":"2019-06-11T12:12:38","modified_gmt":"2019-06-11T04:12:38","slug":"f679264221","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/114725\/","title":{"rendered":"ASCO | \u80c3\u80a0\u9053\u80bf\u7624\u4e24\u5927\u65b0\u770b\u70b9"},"content":{"rendered":"
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\"ASCO<\/p>\n

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\u7b2c 55 \u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\u00ae\uff09\u5728\u829d\u52a0\u54e5\u9686\u91cd\u4e3e\u884c\uff0c\u4e16\u754c\u5404\u5730\u7684\u4e13\u5bb6\u5b66\u8005\u5982\u7ea6\u800c\u81f3\uff0c\u5206\u4eab\u8fd1\u4e00\u5e74\u6765\u80bf\u7624\u5b66\u9886\u57df\u7684\u6700\u65b0\u8fdb\u5c55\u3002<\/p>\n


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\u6211\u56fd\u80bf\u7624\u9886\u57df\u8d85\u767e\u4f4d\u4e13\u5bb6\u5165\u9009\u5927\u4f1a<\/span>\uff0c\u5176\u4e2d\u6c5f\u6cfd\u98de\u3001\u9a6c\u9a8f\u3001\u5f90\u745e\u534e\u3001\u9648\u660e\u8fdc\u3001\u5f20\u8389\u3001\u9676\u8363\u516d\u4f4d\u4e2d\u56fd\u5b66\u8005\u5728\u4f1a\u4e0a\u4f5c\u4e86\u7cbe\u5f69\u7684\u53e3\u5934\u62a5\u544a\u3002<\/span><\/p>\n


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\u4eca\u5929\u662f\u5927\u4f1a\u4e3e\u529e\u7684\u7b2c\u56db\u5929<\/span>\uff0c\u6211\u4eec\u6765\u5173\u6ce8\u4e00\u4e0b\u80c3\u80a0\u9053\u80bf\u7624\u5728\u4f1a\u8bae\u4e0a\u7684\u6700\u65b0\u8fdb\u5c55\u3002<\/p>\n


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\u5f53\u5730\u65f6\u95f4 6 \u6708 2 \u65e5\u4e2d\u5348\uff0c\u300c\u80c3\u80a0\u9053\u80bf\u7624-\u975e\u7ed3\u76f4\u80a0\u764c\u300d\u53e3\u5934\u62a5\u544a\u4e13\u573a\uff08Oral Presentation Session\uff09\uff0c\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388\u5c31\u300cS-1 \u8054\u5408\u5965\u6c99\u5229\u94c2\u5bf9\u6bd4 S-1 \u8054\u5408\u987a\u94c2\u4f5c\u4e3a\u665a\u671f\u5f25\u6f2b\u578b\u6216\u6df7\u5408\u578b\u80c3\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08SOX-GC\uff09\u300d\u4f5c\u4e86\u62a5\u544a\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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\"ASCO<\/p>\n

\u25b3ASCO \u4f1a\u8bae\u6458\u8981<\/span><\/p>\n


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 \u7814\u7a76\u80cc\u666f <\/span><\/strong><\/p>\n


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\u76f8\u5bf9\u4e8e\u80a0\u578b\u80c3\u764c\uff0c\u5f25\u6f2b\u578b\u6216\u6df7\u5408\u578b\u80c3\u764c\u60a3\u8005\u9884\u540e\u8f83\u5dee\uff0c\u4e14 HER2 \u9633\u6027\u6bd4\u4f8b\u5f88\u4f4e\uff0c\u7edd\u5927\u90e8\u5206\u60a3\u8005\u4e0d\u9002\u5408\u63a5\u53d7\u6297 HER2 \u6cbb\u7597\u3002\u5728\u4e9a\u6d32\uff0cS-1 \u8054\u5408\u987a\u94c2\u662f\u665a\u671f\u80c3\u764c\u6807\u51c6\u4e00\u7ebf\u5316\u7597\u65b9\u6848\uff0c\u4f46\u6709\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u4ee5\u5965\u6c99\u5229\u94c2\u4e3a\u57fa\u7840\u7684\u5316\u7597\u65b9\u6848\u53ef\u80fd\u6bd4\u4ee5\u987a\u94c2\u4e3a\u57fa\u7840\u7684\u5316\u7597\u65b9\u6848\u66f4\u52a0\u6709\u6548\uff0c\u4e14\u8010\u53d7\u6027\u66f4\u4f73\u3002<\/p>\n


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\u8be5\u7814\u7a76\u4e94\u5e74\u95f4\u5171\u5165\u7ec4\u4e86 576 \u4f8b\u5e74\u9f84\u5728 18-75 \u5c81\u3001PS 0-2 \u5206\u3001\u65e0\u5668\u5b98\u529f\u80fd\u969c\u788d\u3001\u7ec4\u7ec7\u5b66\u8bc1\u5b9e\u4e3a\u4e0d\u53ef\u5207\u9664\u7684\u665a\u671f\u5f25\u6f2b\u578b\u6216\u6df7\u5408\u578b\u80c3\/\u80c3\u98df\u7ba1\u7ed3\u5408\u5904\u817a\u764c\u60a3\u8005\uff0c\u6309 1:1 \u7684\u6bd4\u4f8b\u968f\u673a\u5206\u81f3 S-1 \u8054\u5408\u5965\u6c99\u5229\u94c2\uff08SOX\uff09\u7ec4\uff08S-1\uff1a40-60 mg\uff0cbid\uff0cd1-14\uff0cq3w\uff1b\u5965\u6c99\u5229\u94c2\uff1a130 mg\/m2\uff0cd1\uff0cq3w\uff09\u6216 SP \u7ec4\uff08S-1\uff1a40-60 mg\uff0cd1-14\uff0cq3w\uff1b\u987a\u94c2\uff1a60 mg\/m2\uff0cd1\uff0cq3w\uff09\u3002<\/p>\n


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\u6bcf\u7ec4\u4eba\u7fa4\u7684\u4e2d\u4f4d\u5316\u7597\u5468\u671f\u6570\u4e3a 4 \u4e2a\u5468\u671f\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\uff08OS\uff09\u671f\uff1b\u6b21\u8981\u7ec8\u70b9\u4e3a\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\u671f\u3001\u6cbb\u7597\u5931\u8d25\u65f6\u95f4\uff08TTF\uff09\u548c\u5316\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u3002<\/p>\n


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 \u7814\u7a76\u7ed3\u679c <\/span><\/strong><\/span><\/p>\n


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\u76f8\u6bd4 SP \u7ec4\u800c\u8a00\uff0cSOX \u7ec4\u7684 OS\uff0813.0 \u4e2a\u6708\u5bf9 11.8 \u4e2a\u6708\uff0cHR = 0.764\uff0c95%CI 0.636-0.918\uff09\u3001PFS\uff085.7 \u4e2a\u6708\u5bf9 4.9 \u4e2a\u6708\uff0cHR = 0.752\uff0c95%CI 0.632-0.895\uff09\u548c TTF\uff085.2 \u4e2a\u6708\u5bf9 4.7 \u4e2a\u6708\uff0cHR = 0.763\uff0c95%CI 0.641-0.909\uff09\u5747\u53d6\u5f97\u6539\u5584;<\/p>\n


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\u5728 \u2265 3 \u7ea7\u7684\u4e0d\u826f\u4e8b\u4ef6\u65b9\u9762\uff0c SOX \u7ec4\u76f8\u8f83 SP \u7ec4\u5728\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0810.0% \u5bf9 22.9%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\uff089.7% \u5bf9 21.9%\uff09\u3001\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff082.5% \u5bf9 6.8%\uff09\u3001\u8d2b\u8840\uff084.3% \u5bf9 14.3%\uff09\u3001\u5455\u5410\uff083.9% \u5bf9 10.4%\uff09\u3001\u6076\u5fc3\uff082.2% \u5bf9 10.4%\uff09\u548c\u98df\u6b32\u4e0b\u964d\uff082.2% \u5bf9 6.8%\uff09\u65b9\u9762\u7684\u53d1\u751f\u7387\u5747\u5360\u4f18\u52bf\u3002<\/p>\n


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\u4f46\u5728 \u2264 2 \u7ea7\u611f\u89c9\u795e\u7ecf\u6bd2\u6027\uff0841.6% \u5bf9 12.2%\uff09\u548c\u809d\u529f\u80fd\u5f02\u5e38\u7684\u53d1\u751f\u7387\u65b9\u9762\uff0cSOX \u7ec4\u8981\u9ad8\u4e8e SP \u7ec4\u3002<\/p>\n


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\u603b\u800c\u8a00\u4e4b\uff0c\u5bf9\u4e8e\u672a\u7ecf\u6cbb\u7597\u7684\u665a\u671f\u5f25\u6f2b\u578b\u6216\u6df7\u5408\u578b\u80c3\/\u80c3\u98df\u7ba1\u7ed3\u5408\u5904\u817a\u764c\u60a3\u8005\u800c\u8a00\uff0c\u76f8\u8f83 SP \u65b9\u6848\uff0cSOX \u65b9\u6848\u65e0\u8bba\u5728\u6709\u6548\u6027\u8fd8\u662f\u8010\u53d7\u6027\u65b9\u9762\uff08\u9664\u611f\u89c9\u795e\u7ecf\u6bd2\u6027\u5916\uff09\u5747\u5360\u636e\u663e\u8457\u4f18\u52bf\u3002<\/p>\n


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\u5f53\u5730\u65f6\u95f4 6 \u6708 1 \u65e5\uff0c\u6765\u81ea\u7f8e\u56fd\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u5065\u5eb7\u764c\u75c7\u4e2d\u5fc3 Thomas J. George \u6559\u6388\u53e3\u5934\u62a5\u544a\u4e86 NGR-GI002 \u7814\u7a76\u2014\u2014\u5728\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\uff08LARC\uff09\u4e2d\u4f7f\u7528 TNT \u6cbb\u7597\u6a21\u5f0f\u7684 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5e73\u53f0\u2014\u2014\u7b2c\u4e00\u5b9e\u9a8c\u7ec4\u521d\u59cb\u7ed3\u679c\u3002<\/span><\/p>\n


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\u8be5\u7814\u7a76\u4e3b\u8981\u8bc4\u4f30\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u4e2d\u52a0\u5165 PARP \u6291\u5236\u5242 veliparib \u540e\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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\"ASCO<\/p>\n

\u25b3ASCO \u4f1a\u8bae\u6458\u8981<\/span><\/p>\n


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\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u7b56\u7565\u5305\u62ec\u5316\u7597\u3001\u653e\u5316\u7597\u548c\u624b\u672f\u3002\u5bf9\u4e8e\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u6700\u7ec8\u8fd9\u4e09\u79cd\u6cbb\u7597\u65b9\u6cd5\u53ef\u80fd\u90fd\u4f1a\u7528\u5230\uff0c\u800c\u786e\u5b9a\u8fd9\u4e9b\u7597\u6cd5\u7684\u6700\u4f73\u987a\u5e8f\u4ee5\u53ca\u5982\u4f55\u5e94\u7528\u662f\u5f88\u91cd\u8981\u7684\u3002<\/span><\/p>\n


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\u65b0\u8f85\u52a9\u6cbb\u7597\uff08neoadjuvant therapy\uff09\u53c8\u79f0\u672f\u524d\u8f85\u52a9\u6cbb\u7597\uff0c\u9996\u6b21\u5728 2017 \u7248\u7f8e\u56fd NCCN \u76f4\u80a0\u764c\u8bca\u6cbb\u6307\u5357\u4e2d\u63d0\u51fa\uff0c\u5373\u5728\u884c\u76f4\u80a0\u764c\u6839\u6cbb\u672f\u524d\u7ed9\u4e88\u653e\u5316\u7597\u7b49\u7efc\u5408\u6cbb\u7597\u3002<\/span><\/p>\n


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\u65b0\u8f85\u52a9\u6cbb\u7597\u53c8\u5305\u62ec\u65b0\u8f85\u52a9\u653e\u7597 (neoadjuvant radiotherapy)\u3001\u65b0\u8f85\u52a9\u5316\u7597 (neoadjuvant chemotherapy) \u4ee5\u53ca\u65b0\u8f85\u52a9\u653e\u5316\u7597 (neoadjuvant chemoradiotherapy)\u3002<\/span><\/p>\n


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\u8fd1\u5e74\u6765 TNT(Total neoadjuvant treatment) \u6a21\u5f0f\u5f00\u59cb\u5728\u4e34\u5e8a\u91c7\u7528\uff0c\u5373\u5c06\u653e\u5316\u7597\u548c\u5316\u7597\u5747\u653e\u5728\u672f\u524d\u8fdb\u884c\uff0c\u624b\u672f\u4f5c\u4e3a\u6cbb\u7597\u7684\u7ec8\u70b9\u3002\u5176\u6700\u5927\u7684\u4f18\u52bf\u662f\u63d0\u9ad8\u4e86\u60a3\u8005\u80bf\u7624\u4e34\u5e8a\u5b8c\u5168\u7f13\u89e3\u7387 (clinical complete remission\uff0cCCR)\uff0c\u4f7f\u5f97 CCR \u7684\u60a3\u8005\u53ef\u4ee5\u907f\u514d\u76f4\u63a5\u624b\u672f\uff0c\u6700\u5927\u9650\u5ea6\u4fdd\u7559\u5668\u5b98\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u4ece\u800c\u63d0\u9ad8\u60a3\u8005\u4fdd\u809b\u7387\u53ca\u751f\u6d3b\u8d28\u91cf\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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 \u7814\u7a76\u65b9\u6cd5 <\/span><\/strong><\/span><\/p>\n


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\u7eb3\u5165\u7814\u7a76\u7684\u2161 \/ \u2162\u671f LARC \u60a3\u8005\u5305\u542b\u4e0b\u5217\u4efb\u4f55\u4e00\u9879\uff1a\u4f4e\u4f4d\u4e2d\u80bf\u7624 (cT3-4 \u8ddd\u809b\u95e8\u8fb9\u7f18 \u2264 5 cm\uff0c\u4efb\u4f55 N)\uff0c\u80bf\u7624\u4f53\u79ef\u5927 (\u4efb\u4f55 cT4 \u6216 3 mm \u5185\u76f4\u80a0\u7cfb\u819c\u7b4b\u819c 3 mm \u5185\u80bf\u7624)\uff0c\u5b58\u5728\u9ad8\u8f6c\u79fb\u98ce\u9669 (cN2)\uff0c\u6216\u65e0\u6cd5\u5b9e\u65bd\u4fdd\u7559\u62ec\u7ea6\u808c\u624b\u672f\u3002<\/span><\/p>\n


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\u60a3\u8005\u968f\u673a\u5206\u914d\u5230\u65b0\u8f85\u52a9 FOLFOX\uff084 \u4e2a\u6708\uff09\u2192\u540c\u6b65\u653e\u5316\u7597+\/- veliparib\u21928\uff5e12 \u5468\u540e\u624b\u672f\u3002<\/span><\/p>\n


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\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1a\u76f4\u80a0\u764c\u65b0\u8f85\u52a9\uff08NAR\uff09\u8bc4\u5206\u964d\u4f4e 4 \u5206\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\uff1aOS\uff08\u603b\u751f\u5b58\u671f\uff09\u3001DFS\uff08\u65e0\u75c5\u751f\u5b58\u671f\uff09\u3001\u6bd2\u6027\u3001PCR\uff08\u75c5\u7406\u5b66\u5b8c\u5168\u7f13\u89e3\uff09\u3001CCR\uff08\u4e34\u5e8a\u5b8c\u5168\u7f13\u89e3\u7387\uff09\u3001\u6cbb\u7597\u5b8c\u6210\u3001\u624b\u672f\u5207\u7f18\u9634\u6027\u7387\u548c\u4fdd\u7559\u62ec\u7ea6\u808c\u624b\u672f\u7387\u3002<\/span><\/p>\n


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 \u7814\u7a76\u7ed3\u679c <\/span><\/strong><\/p>\n


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\u4ece 2016 \u5e74 10 \u6708\u5230 2018 \u5e74 2 \u6708\uff0c<\/span>178 \u4f8b\u60a3\u8005\u968f\u673a\u5206\u7ec4\uff0888 \u4f8b\u5bf9\u7167\u7ec4\uff0c90 \u4f8b veliparib \u7ec4\uff09\u3002140 \u4f8b\u60a3\u8005\u53ef\u8fdb\u884c\u76f4\u80a0<\/span>\u764c\u65b0\u8f85\u52a9\u8bc4\u5206\uff08NAR\uff09\uff0872 \u4f8b\u5bf9\u7167\u7ec4\uff0c68 \u4f8b veliparib \u7ec4\uff09\u3002<\/span><\/p>\n


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\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1a\u5bf9\u7167\u7ec4 NAR \u4e3a 12.6\uff0895%CI\uff1a9.8\uff5e15.3\uff09\uff0cveliparib \u7ec4\u4e3a 13.7\uff0895%CI\uff1a10.2\uff5e17.2\uff09\u3002PCR = 21.6% vs. 33.8%\uff08P = 0.14\uff09; CCR = 28.2% vs. 33.3%\uff08P = 0.60\uff09; \u4fdd\u7559\u62ec\u7ea6\u808c\u624b\u672f\u7387\uff08SSS\uff09= 52.5%vs 59.3%\uff08P = 0.43\uff09\u3002<\/span><\/p>\n


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\u6700\u5e38\u89c1\u7684 3\/4 \u7ea7\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u548c\u9aa8\u9ad3\u6291\u5236\u3002<\/span><\/p>\n


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 \u603b\u7ed3 <\/span><\/strong><\/p>\n


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\u7814\u7a76\u8868\u660e\uff0c\u4f5c\u4e3a TNT \u6cbb\u7597\u7684\u4e00\u90e8\u5206\uff0cVeliparib \u52a0\u5165\u653e\u5316\u7597\u662f\u5b89\u5168\u7684\uff0c\u6ca1\u6709\u610f\u5916\u7684\u77ed\u671f\u6bd2\u6027\uff0c\u4f46\u5e76\u672a\u964d\u4f4e NAR \u8bc4\u5206\u3002<\/p>\n


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\n
\"ASCO<\/section>\n<\/section>\n


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\u6301\u7eed\u5173\u6ce8 ASCO\uff0c\u6211\u4eec\u6709\u66f4\u591a\u8d44\u8baf\u3002<\/span><\/p>\n


<\/p>\n

\"ASCO<\/p>\n


<\/p>\n<\/section>\n

\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n

\u6295\u7a3f\uff1adecie@qq.com
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\u9898\u56fe\uff1aASCO annual 2019<\/span><\/p>\n


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\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

ASCO | \u4e2d\u56fd\u5b66\u8005\u62a5\u9053\u9f3b\u54bd\u764c\u6cbb\u7597\u65b0\u65b9\u6848<\/a><\/span><\/p>\n

ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d<\/span><\/a><\/p>\n

\u7531\u591a\u5230\u5c11\uff1a\u4e73\u817a\u764c\u524d\u54e8\u6d3b\u68c0\u5e94\u8be5\u5982\u4f55\u5e94\u7528\uff1f<\/a><\/span><\/p>\n


<\/p>\n

\"ASCO<\/p>\n

\"ASCO<\/p>\n

\u53c2\u8003\uff1a<\/span><\/p>\n

https:\/\/abstracts.asco.org\/239\/AbstView_239_248637.html<\/span><\/p>\n<\/section>\n

http:\/\/abstracts.asco.org\/239\/AbstView_239_256469.html<\/span><\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u7b2c 55 \u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\u00ae\uff09\u5728\u829d\u52a0\u54e5\u9686\u91cd\u4e3e\u884c\uff0c\u4e16\u754c\u5404\u5730\u7684\u4e13\u5bb6\u5b66\u8005\u5982\u7ea6\u800c\u81f3\uff0c\u5206\u4eab\u8fd1\u4e00\u5e74\u6765\u80bf\u7624\u5b66\u9886\u57df […]<\/p>\n","protected":false},"author":1,"featured_media":114726,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114725"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=114725"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114725\/revisions"}],"predecessor-version":[{"id":114734,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114725\/revisions\/114734"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/114726"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=114725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=114725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=114725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}