{"id":114809,"date":"2019-06-11T12:14:14","date_gmt":"2019-06-11T04:13:24","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/114809\/"},"modified":"2019-06-11T12:13:26","modified_gmt":"2019-06-11T04:13:26","slug":"8b1b0b5cf3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/114809\/","title":{"rendered":"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;letter-spacing: 0.68px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"__bg_gif\"      style=\"letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/7-1560226405.gif\" alt=\"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01\" title=\"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u80bf\u7624\u65f6\u95f4\u8fd1\u671f\u5feb\u62a5\uff0c\u5e26\u7ed9\u4f60\u6700\u65b0\u7684\u8d44\u8baf\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5965\u62c9\u5e15\u5c3c\u6cbb\u7597 BRCA \u7a81\u53d8\u80f0\u817a\u764c<\/span><\/strong><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u90e8\u5206\u80f0\u817a\u764c\u60a3\u8005\u5177\u6709\u5177\u6709\u80da\u7cfb BRCA1\/2 \u7a81\u53d8\uff0cPARP \u6291\u5236\u5242\u5965\u62c9\u5e15\u5c3c\u5728\u8fd9\u90e8\u5206\u4eba\u7fa4\u4e2d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u3002ASCO \u4f1a\u8bae\u540c\u671f\uff0cNEJM \u5728\u7ebf\u53d1\u8868\u4e86 BRCA \u7a81\u53d8\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u63a5\u53d7\u5965\u62c9\u5e15\u5c3c\u7ef4\u6301\u6cbb\u7597\u7684\u968f\u673a\u53cc\u76f2 3 \u671f\u7814\u7a76<sup>[1]<\/sup>\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u5bf9\u4e8e\u5177\u6709\u80da\u7cfb BRCA \u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u6765\u8bf4\uff0c\u5965\u62c9\u5e15\u5c3c\u7ef4\u6301\u6cbb\u7597\u53ef\u663e\u8457\u5ef6\u957f PFS\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\"><span style=\"font-size: 14px;letter-spacing: 0.544px;\">\u7814\u7a76\u8bc4\u4f30\u4e86\u4e00\u7ebf\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u672a\u8fdb\u5c55\u3001\u5177\u6709\u80da\u7cfb BRCA1 \u6216 BRCA2 \u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u5965\u62c9\u5e15\u5c3c\u7ef4\u6301\u6cbb\u7597\u7684\u7597\u6548\u3002\u60a3\u8005\u968f\u673a\uff083:2\uff09\u63a5\u53d7\u5965\u62c9\u5e15\u5c3c 300 mg Bid \u6216\u5b89\u6170\u5242\u7ef4\u6301\u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f PFS\u3002<\/span><span style=\"font-size: 14px;max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">154 \u540d\u60a3\u8005\u968f\u673a\u5e76\u63a5\u53d7\u6cbb\u7597\uff08\u4e24\u7ec4\u5206\u522b 92 \u540d\u548c 62 \u540d\uff09\u3002\u5965\u62c9\u5e15\u5c3c\u7ec4\u7684\u4e2d\u4f4d PFS \u663e\u8457\u5ef6\u957f\uff087.4 \u6708 vs 3.8 \u6708\uff1bHR 0.53\uff1bP = 0.004\uff09\u3002OS \u4e2d\u671f\u5206\u6790\uff08\u6570\u636e\u6210\u719f\u5ea6 46%\uff09\u672a\u53d1\u73b0\u663e\u8457\u5dee\u5f02\uff08\u4e2d\u4f4d\uff0c18.9 \u6708 vs 18.1 \u6708\uff1bHR 0.91\uff1bP = 0.68\uff09\u3002\u4e24\u7ec4\u751f\u6d3b\u8d28\u91cf\u6ca1\u6709\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u4e24\u7ec4 3 \u7ea7\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387 40% vs 23%\uff0c\u5206\u522b\u6709 5% \u548c 2% \u7684\u60a3\u8005\u56e0\u4e3a\u4e0d\u826f\u4e8b\u4ef6\u505c\u836f\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;letter-spacing: 0.68px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e34\u5e8a+\u57fa\u56e0\u98ce\u9669\u8bc4\u4f30\u6307\u5bfc\u4e73\u817a\u764c\u8f85\u52a9\u5316\u7597<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u8bc4\u4f30\u590d\u53d1\u98ce\u9669\u7684\u75c5\u7406\u5b66\u56e0\u7d20\u548c 21 \u57fa\u56e0\u5206\u6790\u53ef\u4ee5\u6307\u5bfc\u4e73\u817a\u764c\u7684\u8f85\u52a9\u5316\u7597\uff0c\u4f46\u8fd8\u4e0d\u6e05\u695a\u4e34\u5e8a\u590d\u53d1\u98ce\u9669\u56e0\u7d20\u662f\u5426\u53ef\u4ee5\u589e\u52a0\u9884\u540e\u8bc4\u5206\u4fe1\u606f\u3002\u4e00\u9879\u5173\u4e8e\u4e34\u5e8a\u98ce\u9669\u5206\u5c42\u7684\u7814\u7a76\u4e8e 6 \u6708 3 \u65e5\u5728\u7ebf\u53d1\u8868\u4e8e NEJM<sup>[2]<\/sup>\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u7eb3\u5165\u4e34\u5e8a\u98ce\u9669\u56e0\u7d20\u53ef\u4ee5\u4e3a 21 \u57fa\u56e0\u590d\u53d1\u8bc4\u5206\u63d0\u4f9b\u989d\u5916\u7684\u9884\u540e\u4fe1\u606f\uff0c\u6709\u52a9\u4e8e\u53d1\u73b0\u80fd\u4ece\u5176\u4ed6\u6709\u6548\u6cbb\u7597\u4e2d\u83b7\u76ca\u7684\u7edd\u7ecf\u524d\u5973\u6027\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;letter-spacing: 0.544px;\">\u524d\u77bb\u6027\u5206\u6790 9427 \u540d\u8fdb\u884c\u8fc7 21 \u57fa\u56e0\u68c0\u6d4b\u7684\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2 \u9634\u6027\u3001\u814b\u7a9d\u6dcb\u5df4\u7ed3\u9634\u6027\u7684\u4e73\u817a\u764c\u60a3\u8005\uff0c\u6839\u636e\u80bf\u7624\u5927\u5c0f\u548c\u7ec4\u7ec7\u5b66\u7ea7\u522b\u628a\u4e34\u5e8a\u590d\u53d1\u98ce\u9669\u5206\u4e3a\u4f4e\u98ce\u9669\u6216\u9ad8\u98ce\u9669\u3002\u901a\u8fc7\u8ba1\u7b97\u8fdc\u5904\u590d\u53d1\u7684 HR \u503c\u8bc4\u4f30\u4e34\u5e8a\u98ce\u9669\u7684\u6548\u5e94\u3002<\/span><span style=\"font-size: 14px;color: rgb(136, 136, 136);max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u5bf9\u4e8e 21 \u57fa\u56e0\u590d\u53d1\u8bc4\u5206 11 \u5230 25 \u5206\u7684\u60a3\u8005\uff0c\u4e34\u5e8a\u98ce\u9669\u6c34\u5e73\uff080-100 \u5206\uff0c\u5206\u503c\u8d8a\u9ad8\uff0c\u9884\u540e\u8d8a\u5dee\uff0c\u5316\u7597\u83b7\u76ca\u8d8a\u9ad8\uff09\u5bf9\u4e8e\u8fdc\u5904\u590d\u53d1\u5177\u6709\u9884\u540e\u610f\u4e49\uff0c\u5305\u62ec\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597\uff08\u9ad8 vs \u4f4e\u4e34\u5e8a\u98ce\u9669 HR 2.73\uff09\u53ca\u5316\u7597+\u5185\u5206\u6ccc\u6cbb\u7597\uff08HR 2.41\uff09\u7684\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u9ad8\u590d\u53d1\u98ce\u9669\u8bc4\u5206\uff0826-100 \u5206\uff09\u7684\u60a3\u8005\u90fd\u63a5\u53d7\u4e86\u5316\u7597\u5185\u5206\u6ccc\u6cbb\u7597\uff08HR 3.17\uff09\u3002\u800c\u53ea\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597\u7684 50 \u5c81\u4ee5\u4e0b\u7684\u60a3\u8005\u4e2d\uff0c\u4f4e\u590d\u53d1\u98ce\u9669\uff080-10 \u5206\uff09\u60a3\u8005\u4e0d\u8bba\u4e34\u5e8a\u98ce\u9669\u5982\u4f55\uff0c\u63a8\u6d4b 9 \u5e74\u8fdc\u5904\u590d\u53d1\u98ce\u9669 \u2264 1.8\u00b10.9%\uff1b\u800c\u4e2d\u590d\u53d1\u8bc4\u5206\u4f4e\u4e34\u5e8a\u98ce\u9669\u7684\u60a3\u8005\u662f 4.7\u00b11.0%\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u8fd9\u4e2a\u5e74\u9f84\u7ec4\u60a3\u8005\u4e2d\uff0c\u9ad8\u4e34\u5e8a\u98ce\u9669\u548c\u4e2d\u590d\u53d1\u8bc4\u5206\u53ea\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u60a3\u8005\u7684\u63a8\u6d4b 9 \u5e74\u8fdc\u5904\u590d\u53d1\u7387 12.3\u00b12.4%\uff0c\u9ad8\u590d\u53d1\u8bc4\u5206\u63a5\u53d7\u5316\u7597\u5185\u5206\u6ccc\u6cbb\u7597\u60a3\u8005\u7684 9 \u5e74\u8fdc\u5904\u590d\u53d1\u7387 15.2\u00b13.3%\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u745e\u535a\u897f\u5c3c\u5ef6\u957f\u4e73\u817a\u764c\u60a3\u8005\u751f\u5b58<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 17px;\"><span style=\"\">\u548c\u5355\u7eaf\u5185\u5206\u6ccc\u6cbb\u7597\u76f8\u6bd4\uff0cCDK4\/6 \u6291\u5236\u5242\u745e\u535a\u897f\u5c3c\uff08ribociclib\uff09\u7684\u52a0\u5165\u53ef\u4ee5\u6539\u5584\u7edd\u7ecf\u524d\u548c\u56f4\u7edd\u7ecf\u671f\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2 \u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684 PFS\u3002NEJM \u4e8e 6 \u6708 2 \u65e5\u520a\u767b\u4e86\u7814\u7a76\u7684\u5173\u952e\u6b21\u8981\u7ec8\u70b9 OS \u6570\u636e<\/span><sup style=\"\">[3]<\/sup><span style=\"\">\u3002<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u7814\u7a76\u8868\u660e\u548c\u5355\u7eaf\u5185\u5206\u6ccc\u6cbb\u7597\u76f8\u6bd4\uff0cCDK4\/6 \u6291\u5236\u5242+\u5185\u5206\u6ccc\u6cbb\u7597\u53ef\u5ef6\u957f\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2 \u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u751f\u5b58\u3002\u957f\u671f\u968f\u8bbf\u6ca1\u6709\u65b0\u7684\u6bd2\u6027\u4e8b\u4ef6\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;text-align: start;widows: 2;color: rgb(63, 63, 63);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\"><span style=\"font-size: 14px;widows: 1;\">\u60a3\u8005\u968f\u673a\u63a5\u53d7\u745e\u535a\u897f\u5c3c\u6216\u5b89\u6170\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\uff08\u6208\u820d\u745e\u6797+\u82b3\u9999\u5316\u9176\u6291\u5236\u5242 [AI] \u6216\u4ed6\u83ab\u6614\u82ac\uff09\u3002<\/span><span style=\"font-size: 14px;max-width: 100%;widows: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">ITT \u4eba\u7fa4\u5305\u62ec 672 \u540d\u60a3\u8005\u3002\u745e\u535a\u897f\u5c3c\u7684\u52a0\u5165\u53ef\u4ee5\u663e\u8457\u5ef6\u957f OS\u3002\u63a8\u6d4b 42 \u4e2a\u6708\u7684 OS \u7387\u5206\u522b\u662f 70.2% vs 46.0%\uff08HR 0.71\uff1bP = 0.00973\uff09\u3002495 \u540d\u63a5\u53d7 AI \u6cbb\u7597\u60a3\u8005\u7684\u4e9a\u7ec4\u7684\u751f\u5b58\u83b7\u76ca\u548c ITT \u4eba\u7fa4\u4e00\u81f4\uff08HR 0.70\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u4e24\u7ec4\u63a5\u53d7\u540e\u7eed\u6297\u80bf\u7624\u6cbb\u7597\u7684\u6bd4\u4f8b\u5e73\u8861\uff08\u5206\u522b\u662f 68.9% \u548c 73.2%\uff09\u3002\u745e\u535a\u897f\u5c3c\u7ec4\u4ece\u968f\u673a\u5230\u4e8c\u7ebf\u6cbb\u7597\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u65f6\u95f4\u4e5f\u66f4\u957f\uff08HR 0.69\uff09\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u5728 PD-L1 \u8868\u8fbe\u7684 NSCLC \u4e2d\u5177\u6709\u6301\u7eed\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002JCO \u4e8e 6 \u6708 2 \u65e5\u4e0e ASCO \u540c\u671f\u516c\u5e03\u4e86 Ib \u671f KEYNOTE-001 \u7814\u7a76\u7684 5 \u5e74\u7ed3\u5c40<sup>[4]<\/sup>\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u5bf9\u4e8e\u521d\u6cbb\u548c\u7ecf\u6cbb\u7684\u8fdb\u5c55\u671f NSCLC \u60a3\u8005\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u5177\u6709\u6301\u7eed\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u5f88\u9ad8\u7684 5 \u5e74 OS \u7387\u3002\u7279\u522b\u5730\uff0c\u5bf9\u4e8e PD-L1 \u2265 50% \u7684\u60a3\u8005\uff0c5 \u5e74 OS \u7387\u8d85\u8fc7\u4e86 25%\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u5177\u6709\u826f\u597d\u7684\u957f\u671f\u5b89\u5168\u6027\uff0c\u5c11\u89c1\u8fdf\u53d1\u6216\u65b0\u7684\u6bd2\u6027\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;letter-spacing: 0.544px;\">\u8fdb\u5c55\u671f NSCLC \u60a3\u8005\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297 2 mg\/kg Q3W \u6216 10 mg\/kg Q2W \u6216 Q3W \u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f ORR\u3002\u6b21\u8981\u7ec8\u70b9\u662f OS \u548c DoR\u3002<\/span><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u7eb3\u5165 101 \u540d\u521d\u6cbb\u548c 449 \u540d\u7ecf\u6cbb\u60a3\u8005\u3002\u4e2d\u4f4d\u968f\u8bbf 60.6 \u4e2a\u6708\uff0c\u521d\u6cbb\u548c\u7ecf\u6cbb\u60a3\u8005\u7684\u4e2d\u4f4d OS \u5206\u522b\u662f 22.3 \u4e2a\u6708\u548c 10.5 \u4e2a\u6708\uff0c\u521d\u6cbb\u548c\u7ecf\u6cbb\u60a3\u8005\u7684\u63a8\u6d4b 5 \u5e74 OS \u7387\u5206\u522b\u662f 23.2% \u548c 15.5%\u3002PD-L1 \u2265 50% \u7684\u60a3\u8005\u4e2d\uff0c\u521d\u6cbb\u548c\u7ecf\u6cbb\u60a3\u8005\u7684 5 \u5e74 OS \u7387\u5206\u522b\u662f 29.6% \u548c 25.0%\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u548c 3 \u5e74\u5206\u6790\u76f8\u6bd4\uff0c\u53ea\u65b0\u53d1\u751f\u4e86 3 \u4f8b 3 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08\u9ad8\u8840\u538b\uff0c\u7cd6\u8010\u91cf\u964d\u4f4e\u548c\u9ad8\u654f\u53cd\u5e94\uff09\u3002\u6ca1\u6709\u8fdf\u53d1\u7684 4 \u6216 5 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fbe\u62c9\u975e\u5c3c+\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684 5 \u5e74\u7ed3\u5c40<\/span><\/strong><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u5177\u6709 BRAF V600E \u6216 V600K \u7684\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a5\u53d7 BRAF \u6291\u5236\u5242+MEK \u6291\u5236\u5242\u53ef\u4ee5\u5ef6\u957f PFS \u548c OS\uff0c\u4f46\u8fd8\u4e0d\u6e05\u695a\u5176\u957f\u671f\u4e34\u5e8a\u7ed3\u5c40\u3002NEJM \u5728 ASCO \u540c\u671f\u516c\u5e03\u4e86\u8054\u5408\u6cbb\u7597\u968f\u673a\u7814\u7a76\u7684\u957f\u671f\u6570\u636e\uff0c\u4ee5\u660e\u786e 5 \u5e74\u751f\u5b58\u7387\u548c\u5177\u6709\u6301\u7eed\u83b7\u76ca\u60a3\u8005\u7684\u4e34\u5e8a\u7279\u5f81<sup>[5]<\/sup>\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u7814\u7a76\u53d1\u73b0\uff0c\u4e00\u7ebf\u63a5\u53d7\u8fbe\u62c9\u975e\u5c3c+\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\u7684 BRAF V600E \u6216 V600K \u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u5927\u7ea6 1\/3 \u60a3\u8005\u5177\u6709\u957f\u671f\u83b7\u76ca\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;letter-spacing: 0.544px;\">\u6c47\u603b COMBI-d \u548c COMBI-v \u7814\u7a76\u4e2d\u63a5\u53d7\u8fbe\u62c9\u975e\u5c3c 150 mg Bid+\u66f2\u7f8e\u66ff\u5c3c 2 mg Qd \u6cbb\u7597\u7684\u521d\u6cbb\u60a3\u8005\u751f\u5b58\u6570\u636e\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4 22 \u4e2a\u6708\uff0cCOMBI-d \u548c COMBI-v \u7684\u9996\u8981\u7ec8\u70b9\u5206\u522b\u662f PFS \u548c OS\u3002<\/span><span style=\"font-size: 14px;color: rgb(136, 136, 136);max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u5171 563 \u540d\u60a3\u8005\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u30024 \u5e74 PFS \u7387\u662f 21%\uff0c5 \u5e74 PFS \u7387\u662f 19%\u30024 \u5e74 OS \u7387\u662f 37%\uff0c5 \u5e74 OS \u7387 34%\u3002\u591a\u53d8\u91cf\u5206\u6790\u4e2d\uff0c\u4e00\u4e9b\u57fa\u7ebf\u56e0\u7d20\uff08\u5982 PS\uff0c\u5e74\u9f84\uff0c\u6027\u522b\uff0c\u8f6c\u79fb\u5668\u5b98\u6570\u76ee\u548c LDH \u6c34\u5e73\uff09\u548c PFS \u53ca OS \u663e\u8457\u76f8\u5173\u3002109 \u540d\u60a3\u8005\uff0819%\uff09\u8fbe\u5230 CR\uff0c\u548c\u957f\u671f\u7ed3\u5c40\u6539\u5584\u76f8\u5173\uff0c\u4ed6\u4eec\u7684 5 \u5e74 OS \u7387\u4e3a 71%\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">TD-M1+\u5e15\u59a5\u73e0\u5355\u6297\u65b0\u8f85\u52a9\u7ed3\u5c40<\/span><\/strong><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">KRISTINE \u662f\u4e00\u9879\u5bf9\u6bd4 T-DM1+\u5e15\u59a5\u73e0\u5355\u6297\uff08T-DM1+P\uff09\u548c\u591a\u897f\u4ed6\u8d5b+\u5361\u94c2+\u66f2\u59a5\u73e0\u5355\u6297+\u5e15\u59a5\u73e0\u5355\u6297\uff08TCH+P\uff09\u65b0\u8f85\u52a9\u6cbb\u7597 HER2 \u9633\u6027 II-III \u671f\u4e73\u817a\u764c\u7684 3 \u671f\u7814\u7a76\u30026 \u6708 3 \u65e5\uff0cJCO \u62a5\u9053\u4e86\u7814\u7a76\u7684 3 \u5e74\u7ed3\u5c40<sup>[6]<\/sup>\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u4e4b\u524d\u5206\u6790\u53d1\u73b0\uff0cT-DM1+P \u5177\u6709\u66f4\u4f4e\u7684\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\uff0844.4% vs 55.7%\uff1bP = 0.016\uff09\uff0c\u4f46\u662f\u66f4\u5c11\u7684 3 \u7ea7\u4ee5\u4e0a\u53ca\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u800c\u672c\u6b21\u968f\u8bbf\u7ed3\u679c\u8868\u660e\u548c TCH+P \u76f8\u6bd4\uff0cT-DM1+P \u5177\u6709\u66f4\u9ad8\u7684 EFS \u4e8b\u4ef6\u98ce\u9669\uff0c\u76f8\u4f3c\u7684\u7684 IDFS \u4e8b\u4ef6\u98ce\u9669\uff0c\u548c\u8f85\u52a9\u9636\u6bb5\u5bfc\u81f4\u505c\u836f\u7684\u66f4\u591a\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n<p><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;max-width: 100%;box-sizing: border-box;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\"><span style=\"font-size: 14px;letter-spacing: 0.544px;\">444 \u540d\u60a3\u8005\u968f\u673a\u63a5\u53d7 T-DM1+P\uff08n = 223\uff09\u6216 TCH+P\uff08n = 221\uff09Q3W \u65b0\u8f85\u52a9\u6cbb\u7597 6 \u5468\u671f\u3002\u63a5\u53d7 T-DM1+P \u7684\u60a3\u8005\u7ee7\u7eed\u8f85\u52a9 T-DM1+P\uff0c\u63a5\u53d7 TCH+P \u7684\u60a3\u8005\u63a5\u53d7\u8f85\u52a9\u66f2\u59a5\u73e0\u5355\u6297+\u5e15\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec EFS\uff0cOS\uff0c\u60a3\u8005\u6c47\u62a5\u7ed3\u5c40\uff0c\u548c\u65e0\u4fb5\u88ad\u75be\u75c5\u751f\u5b58\uff08IDFS\uff09\u3002<\/span><span style=\"font-size: 14px;max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u4e2d\u4f4d\u968f\u8bbf 37 \u4e2a\u6708\uff0cT-DM1+P \u7ec4\u7684 EFS \u4e8b\u4ef6\u98ce\u9669\u66f4\u9ad8\uff08HR 2.61\uff09\uff0c\u672f\u524d\u66f4\u591a\u5c40\u90e8\u533a\u57df\u8fdb\u5c55\u4e8b\u4ef6\uff0815[6.7%] vs 0\uff09\u3002\u4e24\u7ec4\u672f\u540e IDFS \u4e8b\u4ef6\u98ce\u9669\u76f8\u540c\uff08HR 1.11\uff09\u3002\u4e0d\u8bba\u4f55\u79cd\u6cbb\u7597\uff0c\u75c5\u7406\u5b8c\u5168\u53cd\u5e94\u548c IDFS \u4e8b\u4ef6\u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff08HR 0.24\uff09\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">T-DM1+P \u7ec4\u7684 3 \u7ea7\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u66f4\u4f4e\uff0831.8% vs 67.7%\uff09\u3002\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\uff0cT-DM1+P \u7ec4 3 \u7ea7\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\uff0824.5% vs 9.9%\uff09\u548c\u5bfc\u81f4\u505c\u836f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0818.4% vs 3.8%\uff09\u53d1\u751f\u7387\u66f4\u9ad8\u3002\u65b0\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\uff0cT-DM1+P \u7ec4\u7684\u60a3\u8005\u6c47\u62a5\u7ed3\u5c40\u66f4\u4f18\uff0c\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\u4e24\u7ec4\u76f8\u4f3c\u3002<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"white-space: normal;max-width: 100%;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(95, 156, 239);display: inline-block;vertical-align: top;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\">6 \u4e2a\u6708\uff1f12 \u4e2a\u6708\uff1f<\/span><\/strong><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 676.991px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\"><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u7684\u6807\u51c6\u6301\u7eed\u65f6\u95f4\u662f 12 \u4e2a\u6708\uff0c\u5b66\u8005\u4eec\u5728\u63a2\u7d22\u66f4\u77ed\u7684\u6cbb\u7597\u662f\u5426\u5177\u6709\u76f8\u540c\u6548\u529b\u548c\u66f4\u5c0f\u6bd2\u6027\u3002The Lancet \u4e8e 6 \u6708 6 \u65e5\u540c\u65f6\u520a\u767b\u4e86 PERSEPHONE<sup>[7]<\/sup>&nbsp;\u548c PHARE<sup>[8]<\/sup>&nbsp;\u4e24\u4e2a\u5bf9\u6bd4\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597 6 \u4e2a\u6708\u548c 12 \u4e2a\u6708\u7684\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\">\u5305\u62ec 4089 \u540d\u60a3\u8005\u7684 PERSEPHONE \u7814\u7a76\u8bc1\u5b9e\u4e86 6 \u4e2a\u6708\u6cbb\u7597\u7684\u975e\u52a3\u6548\uff0c\u7ed3\u679c\u652f\u6301\u51cf\u5c11\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u65f6\u95f4\uff1b\u800c\u7eb3\u5165 3380 \u540d\u60a3\u8005\u7684 PHARE \u7814\u7a76\u5374\u672a\u80fd\u8bc1\u5b9e 6 \u4e2a\u6708\u7684\u975e\u52a3\u6548\uff0c\u8ba4\u4e3a\u6807\u51c6\u6cbb\u7597\u65f6\u95f4\u4ecd\u5e94\u8be5\u662f 12 \u4e2a\u6708\u3002\u77db\u76fe\u7684\u6570\u636e\u4ee4\u8fd9\u4e00\u95ee\u9898\u66f4\u52a0\u6251\u6714\u8ff7\u79bb\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 17px;\"><\/span><\/p>\n<section class=\"\" style=\"margin-right: auto;margin-left: auto;padding: 1em;font-size: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;widows: 1;height: 10em;line-height: 1.5em;overflow: auto;background-color: rgb(240, 240, 240);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong><span style=\"font-size: 14px;color: rgb(136, 136, 136);letter-spacing: 0.544px;\">PERSEPHONE \u7814\u7a76\uff1a<\/span><\/strong><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u60a3\u8005\u968f\u673a\uff081:1\uff09\u968f\u673a\u63a5\u53d7 6 \u4e2a\u6708\uff08n = 2044\uff09\u6216 12 \u4e2a\u6708\uff08n = 2045\uff09\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f DFS\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u4e2d\u4f4d\u968f\u8bbf 5.4 \u5e74\uff0c4 \u5e74 DFS \u7387\u5206\u522b\u662f 89.4% vs 89.8%\uff08HR 1.07\uff0c\u975e\u52a3\u6548 p = 0.011\uff09\uff0c\u8868\u660e 6 \u4e2a\u6708\u6cbb\u7597\u7684\u975e\u52a3\u6548\u30026 \u4e2a\u6708\u6cbb\u7597\u7684\u60a3\u8005\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0819% vs 24%\uff09\u6216\u56e0\u4e3a\u5fc3\u810f\u6bd2\u6027\u505c\u836f\uff083% vs 8%\uff09\u53d1\u751f\u7387\u66f4\u4f4e\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><strong><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">PHARE \u7814\u7a76\uff1a<\/span><\/strong><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u60a3\u8005\u968f\u673a\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297 6 \u4e2a\u6708\uff08n = 1690\uff09\u6216 12 \u4e2a\u6708\uff08n = 1690\uff09\u8f85\u52a9\u6cbb\u7597\u3002\u9996\u8981\u7ec8\u70b9\u662f DFS\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u4e2d\u4f4d\u968f\u8bbf 7.5 \u5e74\uff0cDFS \u8c03\u6574 HR 1.08\uff08p = 0.39\uff09\uff0c\u975e\u52a3\u6548\u8fb9\u7f18\u5305\u542b\u5728 95% CI \u533a\u95f4\u5185\u3002\u5b89\u5168\u6027\u4e8b\u4ef6\u4e0e\u4e4b\u524d\u62a5\u9053\u4e00\u81f4\u3002<\/span><\/p>\n<\/section>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);widows: 1;text-align: center;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u6ed1\u52a8\u67e5\u770b\u7814\u7a76\u8be6\u60c5\uff09<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;transform: translate3d(0px, 0px, 0px);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.7px;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 0.7px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6295\u7a3f\uff1adecie@qq.com<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9898\u56fe\uff1a<span style=\"max-width: 100%;letter-spacing: 0.544px;text-align: left;\">\u7ad9\u9177\u6d77\u6d1bplus<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n<h2 class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;text-align: left;line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653283901&amp;idx=2&amp;sn=4fcc6adcbf1bfb23022447ebaa946054&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/a><\/h2>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284127&amp;idx=1&amp;sn=20d004b9ed50ecdff49e7483ca10f9c9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO&nbsp;| \u4e2d\u56fd\u5b66\u8005\u62a5\u9053\u9f3b\u54bd\u764c\u6cbb\u7597\u65b0\u65b9\u6848<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284133&amp;idx=1&amp;sn=586e3dbe2aad94c9755d353ee91dd58d&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d<\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284144&amp;idx=1&amp;sn=d67af54ea9940497763b724334a0a2d8&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO | \u80c3\u80a0\u9053\u80bf\u7624\u4e24\u5927\u65b0\u770b\u70b9<\/a><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284160&amp;idx=1&amp;sn=8e3acb65439ffc6a287e8a75360f543d&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;\">ASCO |&nbsp;\u4e2d\u56fd\u4e73\u817a\u764c\u5b66\u8005\u7684\u58f0\u97f3<\/span><\/a><\/p>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages __bg_gif\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/6-1560226406.gif\" alt=\"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01\" title=\"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;transform: translate3d(0px, 0px, 0px);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;font-size: 14px;letter-spacing: 0.7px;line-height: 1.9;color: rgb(160, 160, 160);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"          style=\"font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 657px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/9-1560226406.png\" alt=\"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01\" title=\"\u80bf\u7624\u5feb\u62a5 | K \u836f\u6cbb\u7597\u80ba\u764c\u7684 5 \u5e74\u751f\u5b58\u6570\u636e\u51fa\u7089\uff01\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;letter-spacing: 0.7px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">1 Golan T et al. Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. N Engl J Med 2019 Jun 2<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">2 Sparano JA et al. Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer. N Engl J Med 2019 Jun 3<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">3 Im SA et al. Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer. N Engl J Med 2019 Jun 4<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">4 Garon EB et al. Five-Year Overall Survival for Patients With Advanced Non\u2012Small- Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study. J Clin Oncol 2019 Jun 2<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">5 Robert C et al. Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma. N Engl J Med 2019 Jun 4<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">6 Hurvitz SA et al. Neoadjuvant Trastuzumab Emtansine and Pertuzumab in Human Epidermal Growth Factor Receptor 2\u2013Positive Breast Cancer: Three-Year Outcomes From the Phase III KRISTINE Study. J Clin Oncol 2019 Jun 3<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">7 Earl HM et al. 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial. The Lancet 2019 Jun 6<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);white-space: normal;line-height: 1.5;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75;color: rgb(63, 63, 63);font-size: 16px;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">8 Pivot X et al. 6 months versus 12 months of adjuvant trastuzumab in early breast cancer (PHARE): final analysis of a multicentre, open-label, phase 3 randomised trial. The Lancet 2019 Jun 6<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80bf\u7624\u65f6\u95f4\u8fd1\u671f\u5feb\u62a5\uff0c\u5e26\u7ed9\u4f60\u6700\u65b0\u7684\u8d44\u8baf\u3002 \u5965\u62c9\u5e15\u5c3c\u6cbb\u7597 BRCA \u7a81\u53d8\u80f0\u817a\u764c \u90e8\u5206\u80f0\u817a\u764c\u60a3\u8005\u5177\u6709\u5177\u6709\u80da\u7cfb BRCA [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":114810,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114809"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=114809"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114809\/revisions"}],"predecessor-version":[{"id":114814,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114809\/revisions\/114814"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/114810"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=114809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=114809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=114809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}