{"id":114820,"date":"2019-06-11T12:14:21","date_gmt":"2019-06-11T04:13:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/114820\/"},"modified":"2019-06-11T12:13:34","modified_gmt":"2019-06-11T04:13:34","slug":"42bbbb75eb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/114820\/","title":{"rendered":"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\">\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/5-1560226412.gif\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u662f\u5168\u7403\u4e0a\u5347\u6700\u5feb\u7684\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u75c5\u56e0\u4e4b\u4e00\uff0c\u4f46\u7531\u4e8e\u5176\u65e9\u671f\u65e0\u660e\u663e\u7279\u5f02\u6027\u75c7\u72b6\uff0c\u4ee5\u53ca\u6cbb\u7597\u9776\u70b9\u7f3a\u4e4f\uff0c\u65e9\u671f HCC \u7684\u8bca\u65ad\u548c\u7cbe\u51c6\u6cbb\u7597\u4e25\u91cd\u4e0d\u8db3\u3002\u4e09\u5206\u4e4b\u4e8c\u7684 HCC \u60a3\u8005\u521d\u8bca\u65f6\u5df2\u4e3a\u665a\u671f\uff0c\u51e0\u4e4e\u6ca1\u6709\u65f6\u95f4\u8fdb\u884c\u4efb\u4f55\u6709\u6548\u7684\u6cbb\u7597\u3002\u764c\u75c7\u5728\u4e0d\u540c\u9636\u6bb5\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u4e0d\u540c\uff0c\u800c\u76ee\u524d\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u665a\u671f HCC\uff0c\u56e0\u6b64\u4e9f\u5f85\u4ee5\u65e9\u671f\u809d\u764c\u4f5c\u4e3a\u76f4\u63a5\u7814\u7a76\u5bf9\u8c61\u8fdb\u884c\u63a2\u7a76\u3002<br  \/><\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u800c\u8fd1\u65e5\uff0c\u7531\u7b2c\u4e8c\u519b\u533b\u5927\u5b66\u4e1c\u65b9\u809d\u80c6\u5916\u79d1\u533b\u9662\u56fd\u9645\u5408\u4f5c\u751f\u7269\u4fe1\u53f7\u8f6c\u5bfc\u7814\u7a76\u4e2d\u5fc3\u3001\u56fd\u5bb6\u809d\u764c\u79d1\u5b66\u4e2d\u5fc3\u53d1\u8868\u5728 HEPATOLOGY \u4e0a\u7684\u4e00\u7bc7\u6587\u7ae0\u5219\u4e3a\u6211\u4eec\u5c55\u793a\u4e86\u809d\u7ec6\u80de\u764c\u53d1\u751f\u53d1\u5c55\u7684\u5206\u5b50\u673a\u5236\uff0c\u4e3a\u809d\u764c\u65e9\u671f\u8bca\u65ad\u548c\u7cbe\u51c6\u6cbb\u7597\u62d3\u5bbd\u4e86\u524d\u666f\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<section class=\"_135editor\"      style=\"margin-right: auto;margin-left: auto;width: 556px;\">\n<section  style=\"width: 556px;\">\n<section style=\"padding-left: 6px;border-left: 6px solid rgb(61, 170, 214);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding: 2px 12px;background: rgb(61, 170, 214);display: inline-block;letter-spacing: 1.5px;color: rgb(255, 255, 255);font-size: 16px;box-sizing: border-box;\">\u8ba9\u6211\u4eec\u6765\u8ba4\u8bc6\u4e00\u4e0b\u4ec0\u4e48\u662f\u73af\u72b6 RNA<\/section>\n<\/section>\n<section style=\"padding-left: 5px;box-sizing: border-box;\">\n<section style=\"border-bottom: 1px solid rgb(208, 208, 208);border-left: 1px solid rgb(208, 208, 208);border-top: none;border-right: none;box-sizing: border-box;\">\n<section  class=\"135brush\" style=\"padding: 1em;font-size: 14px;letter-spacing: 1.5px;line-height: 1.75em;box-sizing: border-box;\">\n<p><span style=\"font-size: 16px;\">\u73af\u72b6 RNA \u5448\u5c01\u95ed\u73af\u72b6\u7ed3\u6784\uff0c\u5728\u751f\u7269\u4f53\u4e2d\u7a33\u5b9a\u5b58\u5728\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u73af\u72b6 RNA \u5177\u6709\u91cd\u8981\u7684\u751f\u7269\u5b66\u610f\u4e49\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 16px;\">2013 \u5e74 Nature \u6742\u5fd7\u53d1\u8868\u7684\u4e24\u9879\u7814\u7a76\u663e\u793a\uff0c\u73af\u72b6 RNA \u53ef\u4ee5\u8d77\u5230 microRNA \u6d77\u7ef5\u7684\u4f5c\u7528\uff0c\u5373\u901a\u8fc7\u78b1\u57fa\u4e92\u8865\u914d\u5bf9\u4f5c\u7528\u50cf\u6d77\u7ef5\u4e00\u6837\u5438\u9644 microRNA\uff0c\u4ece\u800c\u6291\u5236 microRNA \u7684\u6d3b\u6027\uff0c\u8fdb\u800c\u8c03\u63a7\u5176\u9776\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 16px;\">\u672c\u6587\u4e2d\u7684\u4e3b\u89d2\u5219\u662f Circ-CDYL\uff1a\u7531\u4eb2\u672c\u57fa\u56e0 CDYL\uff08chromodomain on Y-like\uff09\u7684 2 \u53f7\u5916\u663e\u5b50\u9996\u5c3e\u76f8\u63a5\u4ea7\u751f\uff0c\u5e76\u4e14\u5728 HCC \u7684\u6781\u65e9\u671f\u548c\u65e9\u671f\u9636\u6bb5\uff08BCLC 0 \u671f\u548c A HCC\uff09\u7279\u5f02\u6027\u9ad8\u8868\u8fbe\u7684\u73af\u72b6 RNA\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"width: 1.2em;background: rgb(61, 170, 214);height: 6px;float: right;color: rgb(255, 255, 255);\"><br  \/><\/section>\n<section style=\"clear: both;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"_135editor\"  >\n<p><br  \/><\/p>\n<\/section>\n<p style=\"width: 556px;text-align: center;\"><img class=\"\"     style=\"width: 70px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/1-1560226412.gif\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c31\u6765\u8ba4\u771f\u5b66\u4e60\u4e00\u4e0b\u8fd9\u4e2a\u7814\u7a76\u3002<\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/3-1560226412.jpg\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"display: flex;justify-content: center;align-items: center;\">\n<section style=\"width: 2.5em;transform: rotate(0deg);\"><img class=\"\"      style=\"width: 42.5px;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/0-1560226413.png\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/section>\n<section style=\"margin-left: -8px;padding-bottom: 2px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"margin-top: 15px;padding-bottom: 5px;color: rgb(102, 102, 102);letter-spacing: 1.5px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\u7814\u7a76\u8bc1\u5b9e\u4e86 Circ-CDYL \u7684\u529f\u80fd<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><strong><span style=\"color: rgb(61, 170, 214);\">Circ-CDYL \u7684\u8fc7\u8868\u8fbe\u4fc3\u8fdb\u4e86\u809d\u764c\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u3001\u6076\u6027\u589e\u6b96\u3001\u4f53\u5916\u5316\u7597\u836f\u7269\u62b5\u6297\u548c\u4f53\u5185\u81f4\u7624\u6027\uff0c\u800c\u6291\u5236 Circ-CDYL \u7684\u8868\u8fbe\u5219\u5bfc\u81f4\u76f8\u53cd\u7684\u6548\u679c\u3002<\/span><\/strong>\u5c24\u5176\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cCirc-CDYL \u5347\u9ad8\u4e86 EPCAM \u9633\u6027\u7684\u809d\u80bf\u7624\u8d77\u59cb\u7ec6\u80de\uff08T-ICs\uff09\u7684\u6bd4\u4f8b\u53ca\u6837\u57fa\u56e0\u8868\u8fbe\uff0c\u4e3a\u7814\u7a76 Circ-CDYL \u5728 HCC \u53d1\u751f\u4e2d\u7684\u4f5c\u7528\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u7814\u7a76\u901a\u8fc7\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u3001\u62a5\u544a\u57fa\u56e0\u5b9e\u9a8c\u3001\u4f4d\u70b9\u4fdd\u62a4\u5b9e\u9a8c\u548c\u751f\u7269\u7d20\u6807\u8bb0\u7684 miRNA pull-down \u5b9e\u9a8c\u7684\u7efc\u5408\u5206\u6790\u8bc1\u5b9e\u4e86\u7f16\u7801\u809d\u764c\u884d\u751f\u751f\u957f\u56e0\u5b50\uff08HDGF\uff09\u548c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\u5929\u51ac\u9170\u80fa\u7f9f\u5316\u9176\uff08HIF1AN\uff09\u5206\u522b\u662f miR-892a \u548c miR-328-3p \u7684\u76f4\u63a5\u9776\u57fa\u56e0\uff1b\u800c Circ-CDYL \u901a\u8fc7\u7ade\u4e89\u6027\u7ed3\u5408 miR-892a \u548c miR-328-3p\uff0c\u5206\u522b\u4e0e HDGF \u548c HIF1AN \u7684 mRNA \u5f62\u6210\u76f8\u4e92\u4f5c\u7528\u7684\u7f51\u7edc\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">Circ-CDYL \u4e0e HDGF\u3001HIF1AN \u7279\u5f02\u6027\u5730\u5728 HCC \u7684\u65e9\u671f\u9636\u6bb5\u5448\u73b0\u540c\u5411\u5347\u9ad8\u548c\u8868\u8fbe\u6b63\u76f8\u5173\uff0c\u5e76\u4e14\u5e72\u6270\u4e09\u8005\u4e2d\u7684\u4efb\u4f55\u4e00\u4e2a\uff0c\u90fd\u53ef\u4ee5\u901a\u8fc7 miRNA \u548c 3&#8217;UTR \u4f9d\u8d56\u6027\u6a21\u5f0f\u5f15\u8d77\u53e6\u5916\u4e24\u8005\u7684\u53d8\u5316\uff0c\u8868\u660e Circ-CDYL \u4ee5\u5178\u578b\u7684\u7ade\u4e89\u6027\u5185\u6e90 RNA\uff08ceRNA\uff09\u7f51\u7edc\u8c03\u8282\u6a21\u5f0f\u4e0e HDGF \u548c HIF1AN \u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"display: flex;justify-content: center;align-items: center;\">\n<section style=\"width: 2.5em;transform: rotate(0deg);\"><img class=\"\"      style=\"width: 42.5px;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/8-1560226413.png\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/section>\n<section style=\"margin-left: -8px;padding-bottom: 2px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"margin-top: 15px;padding-bottom: 5px;color: rgb(102, 102, 102);letter-spacing: 1.5px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\u7814\u7a76\u8bc1\u5b9e Circ-CDYL \u4fc3\u8fdb HCC \u53d1\u751f<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.75em;font-family: &quot;PingFang SC&quot;\"><span style=\"font-size: 16px;color: rgb(63, 63, 63);text-decoration-style: solid;text-decoration-color: rgb(63, 63, 63);\">Circ-CDYL \u901a\u8fc7\u9a71\u52a8\u4ee5\u4e0b\u4e24\u6761\u8c03\u63a7\u9014\u5f84\u5728\u4f53\u5916\u548c\u4f53\u5185\u6c34\u5e73\u4fc3\u8fdb HCC \u80bf\u7624\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u9996\u5148\uff0cCirc-CDYL \u589e\u52a0 HDGF \u7684\u8868\u8fbe\u548c\u5206\u6ccc\uff0c\u4fc3\u8fdb HDGF \u4e0e\u5176\u53d7\u4f53 NUCLEOLIN \u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4 PI3K-AKT \u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\uff0c\u6d3b\u5316\u4e0b\u6e38 mTOR \/ P70 S6K \u548c GSK3\u03b2\/\u03b2-catenin \u4e24\u6761\u9014\u5f84\uff0c\u6700\u7ec8\u589e\u5f3a\u6548\u5e94\u86cb\u767d C-MYC \u539f\u764c\u57fa\u56e0\u548c SURVIVIN\uff08\u53c8\u540d BIRC5\uff09\u7684\u8868\u8fbe\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u5176\u6b21\uff0cHIF1AN \u7684\u4e0a\u8c03\u6291\u5236\u4e86 NOTCH2 \u7684\u6d3b\u6027\uff0c\u5e76\u56e0\u6b64\u89e3\u9664\u4e86 NOTCH2 \u5bf9 SURVIVIN \u7684\u8f6c\u5f55\u6291\u5236\uff0c\u4fc3\u8fdb\u4e86 SURVIVIN \u7684\u8868\u8fbe\u3002<\/p>\n<\/li>\n<\/ul>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><strong><span style=\"color: rgb(61, 170, 214);\">\u7531\u6b64\u53ef\u89c1\uff0cSURVIVIN \u540c\u65f6\u53d7\u5230 HDGF \u548c HIF1AN \u7684\u8c03\u8282\uff0c\u4e5f\u5c31\u662f\u8bf4 SURVIVIN \u6700\u7ec8\u7531 Circ-CDYL \u9a71\u52a8\u5347\u9ad8\u8868\u8fbe\u3002<\/span><\/strong><\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"display: flex;justify-content: center;align-items: center;\">\n<section style=\"width: 2.5em;transform: rotate(0deg);\"><img class=\"\"      style=\"width: 42.5px;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/0-1560226413-1.png\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/section>\n<section style=\"margin-left: -8px;padding-bottom: 2px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"margin-top: 15px;padding-bottom: 5px;color: rgb(102, 102, 102);letter-spacing: 1.5px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\u7814\u7a76\u4e3a HCC \u65b0\u7597\u6cd5\u63d0\u4f9b\u4e86\u5206\u5b50\u57fa\u7840<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u8be5\u7814\u7a76\u53d1\u73b0 Circ-CDYL \u8bf1\u5bfc\u7684 SURVIVIN \u548c C-MYC \u5347\u9ad8\uff0c\u80fd\u88ab\u9176\u6d3b\u6027\u6291\u5236\u5242 Wortmannin \u548c NOD \u5206\u522b\u9006\u8f6c\uff0c\u4e8c\u8005\u5206\u522b\u9776\u5411 PI3K \u548c HIF1AN\u3002\u8fd9\u4e9b\u5b9e\u9a8c\u7ed3\u679c\u5f3a\u5316\u4e86 Circ-CDYL \u901a\u8fc7\u4e24\u79cd\u8c03\u8282\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\u4fc3\u8fdb HCC \u4e2d\u7ec6\u80de\u6076\u6027\u8868\u578b\u548c\u80bf\u7624\u53d1\u751f\u7684\u89c2\u70b9\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u66f4\u91cd\u8981\u7684\u662f\uff0c<strong><span style=\"color: rgb(61, 170, 214);\">\u7814\u7a76\u63d0\u4f9b\u4e86\u6cbb\u7597\u65e9\u8d77\u809d\u764c\u7684\u65b0\u601d\u8def\uff0c\u5373\u5e72\u6270 Circ-CDYL \u4e0e PI3K \u4ee5\u53ca HIF1AN \u6291\u5236\u5242\u76f8\u7ed3\u5408\uff0c\u53ef\u5728\u4f53\u5916\u548c\u4f53\u5185\u8fbe\u5230\u6291\u5236 HCC \u4e2d\u7684\u6837\u7279\u5f81\u548c\u80bf\u7624\u751f\u957f\u7684\u6700\u4f73\u6548\u679c\u3002<\/span><\/strong><\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section style=\"display: flex;justify-content: center;align-items: center;\">\n<section style=\"width: 2.5em;transform: rotate(0deg);\"><img class=\"\"      style=\"width: 42.5px;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/10-1560226413.png\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/section>\n<section style=\"margin-left: -8px;padding-bottom: 2px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"margin-top: 15px;padding-bottom: 5px;color: rgb(102, 102, 102);letter-spacing: 1.5px;border-bottom: 1px solid rgb(232, 193, 49);box-sizing: border-box;\">Circ-CDYL \u6216\u6210\u4e3a HCC \u65e9\u671f\u76d1\u6d4b\u6307\u6807<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u6700\u540e\uff0c\u4f5c\u8005\u63a2\u7a76\u4e86\u5229\u7528 Circ-CDYL \u5bf9\u65e9\u671f HCC \u8fdb\u884c\u8bca\u65ad\u6216 HCC \u9ad8\u5371\u4eba\u7fa4\u8fdb\u884c\u76d1\u6d4b\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><span style=\"color: rgb(61, 170, 214);\"><strong>\u5c06 Circ-CDYL \u4e0e HDGF \u548c HIF1AN \u7ec4\u5408\u4f5c\u4e3a\u9274\u522b BCLC 0 \u671f\u548c A \u671f HCC \u7684\u4e00\u7ec4\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u8fbe\u5230\u4e86\u6700\u4f73\u6c34\u5e73<\/strong><\/span><strong><span style=\"color: rgb(61, 170, 214);\">\uff0c<\/span><\/strong>\u8868\u660e\u5355\u7528\u8fd9\u7ec4\u751f\u7269\u6807\u5fd7\u7269\u6216\u4e0e\u5176\u4ed6\u4f20\u7edf\u8bca\u65ad\u65b9\u6cd5\u76f8\u7ed3\u5408\uff0c\u662f\u6709\u6f5c\u529b\u7684\u65e9\u671f HCC \u8bca\u65ad\u548c\u9ad8\u5371\u4eba\u7fa4\u7b5b\u67e5\u6807\u5fd7\u7269\u3002<\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<p style=\"line-height: 1.75;color: rgb(63, 63, 63);font-family: &quot;PingFang SC&quot;\">\u8be5\u7814\u7a76\u663e\u793a\uff0c\u8fd9\u7ec4\u751f\u7269\u6807\u5fd7\u7269\u7ec4\u5408\u5bf9\u65e9\u671f HCC \u8bca\u65ad\u6548\u80fd\u4f18\u4e8e AFP\u3002<\/p>\n<p style=\"color: rgb(0, 0, 0);line-height: 1.5;font-family: &quot;PingFang SC&quot;\"><br  \/><\/p>\n<hr style=\"border-style: solid;border-right-width: 0px;border-bottom-width: 0px;border-left-width: 0px;border-color: rgba(0, 0, 0, 0.1);transform-origin: 0px 0px;transform: scale(1, 0.5);\"  \/>\n<p><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"  >\n<section style=\"padding: 1.5em;margin:1em;height: auto;overflow: hidden;box-shadow: #666666 0px 0px 10px;box-sizing: border-box;\">\n<p style=\"width: 100%;box-sizing: border-box;\"><img loading=\"lazy\" border=\"0\" class=\"\"     height=\"\" style=\"display: inline;\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" width=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/5-1560226413.jpeg\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/p>\n<p style=\"width: 100%;box-sizing: border-box;\"><br  \/><\/p>\n<section  style=\"margin-top: 2em;margin-right: auto;margin-left: auto;width: 100%;box-sizing: border-box;\">\n<section style=\"margin-top: -1.5em;text-align: center;font-size: 1em;line-height: 2em;color: #6b6c6e;box-sizing: border-box;\" class=\"135brush\">\n<p style=\"color: rgb(51, 51, 51);font-size: 17px;text-align: justify;line-height: 2em;\"><span style=\"color: rgb(63, 63, 63);font-size: 15px;\">\u672c\u6587\u901a\u8baf\u4f5c\u8005\u738b\u7ea2\u9633\u6559\u6388\u2014\u2014\u80bf\u7624\u5b66\u3001\u5206\u5b50\u751f\u7269\u5b66\u4e13\u5bb6\uff0c\u53d1\u5c55\u4e2d\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\uff0c\u6559\u80b2\u90e8\u957f\u6c5f\u7279\u8058\u6559\u6388\u3001\u4e3b\u4efb\u533b\u5e08\u3001\u535a\u58eb\u751f\u5bfc\u5e08\u3001\u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\u3002\u73b0\u4efb\u56fd\u5bb6\u809d\u764c\u79d1\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u3001\u56fd\u9645\u5408\u4f5c\u751f\u7269\u4fe1\u53f7\u8f6c\u5bfc\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3002\u957f\u671f\u4ece\u4e8b\u80bf\u7624\u7684\u57fa\u7840\u4e0e\u4e34\u5e8a\u7814\u7a76\uff0c\u5bf9\u80bf\u7624\u7684\u4fe1\u53f7\u7f51\u7edc\u8c03\u63a7\u3001\u809d\u764c\u65b0\u5206\u5b50\u6807\u5fd7\u7269\u9274\u5b9a\u53ca\u5e94\u7528\u7b49\u6709\u91cd\u8981\u5efa\u6811\u3002\u5148\u540e\u4e3b\u6301\u56fd\u5bb6\u4f20\u67d3\u75c5\u91cd\u5927\u79d1\u6280\u4e13\u9879\u8bfe\u9898\u3001\u56fd\u5bb6\u521b\u65b0\u7814\u7a76\u7fa4\u4f53\u57fa\u91d1\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u91cd\u70b9\u9879\u76ee\u7b49\u3002<\/span><\/p>\n<p style=\"color: rgb(51, 51, 51);font-size: 17px;text-align: justify;line-height: 2em;\"><br  \/><\/p>\n<p style=\"color: rgb(51, 51, 51);font-size: 17px;text-align: justify;line-height: 2em;\"><span style=\"font-size: 15px;\"><span style=\"color: rgb(63, 63, 63);\">\u5185\u5bb9\u6765\u81ea\u56fd\u5bb6<\/span><span style=\"color: rgb(63, 63, 63);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">\u809d\u764c\u79d1\u5b66\u4e2d\u5fc3\u2014\u2014\u56fd\u5bb6\u809d\u764c\u79d1\u5b66\u516c\u5171\u670d\u52a1\u5e73\u53f0\u3001\u56fd\u5bb6\u5b66\u672f\u4ea4\u6d41\u548c\u9ad8\u5c42\u6b21\u809d\u764c\u7814\u7a76\u4eba\u5458\u57f9\u517b\u57fa\u5730\uff0c\u56fd\u5bb6\u809d\u764c\u96c6\u6210\u7814\u7a76\u4e2d\u5fc3\u3001\u56fd\u5bb6\u809d\u764c\u7814\u7a76\u4f18\u52bf\u8d44\u6e90\u5171\u4eab\u5e73\u53f0\u3001\u9ad8\u5c42\u6b21\u809d\u764c\u7814\u7a76\u4eba\u624d\u57f9\u517b\u57fa\u5730\u3001\u56fd\u5bb6\u809d\u764c\u79d1\u5b66\u7684\u516c\u5171\u670d\u52a1\u5e73\u53f0\u3001\u56fd\u9645\u5b66\u672f\u4ea4\u6d41\u4e0e\u5408\u4f5c\u4e2d\u5fc3\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<\/section>\n<p style=\"margin-right: 48px;margin-left: 48px;text-align: center;\"><br  \/><\/p>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.7px;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1adecie | \u8d23\u4efb\u7f16\u8f91\uff1a\u738b\u5f18<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;background-color: rgb(255, 255, 255);color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.7px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 0.7px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6295\u7a3f\uff1adecie@qq.com<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(62, 62, 62);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9898\u56fe\uff1aHepatology \u6587\u7ae0\u5c01\u9762<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(61, 170, 214);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284127&amp;idx=1&amp;sn=20d004b9ed50ecdff49e7483ca10f9c9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO&nbsp;| \u4e2d\u56fd\u5b66\u8005\u62a5\u9053\u9f3b\u54bd\u764c\u6cbb\u7597\u65b0\u65b9\u6848<\/a><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284133&amp;idx=1&amp;sn=586e3dbe2aad94c9755d353ee91dd58d&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO | DDR \u901a\u8def\u7684\u300c\u673a\u9047\u4e0e\u6311\u6218\u300d<\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284144&amp;idx=1&amp;sn=d67af54ea9940497763b724334a0a2d8&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO | \u80c3\u80a0\u9053\u80bf\u7624\u4e24\u5927\u65b0\u770b\u70b9<\/a><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MzAwMjcyMA==&amp;mid=2653284160&amp;idx=1&amp;sn=8e3acb65439ffc6a287e8a75360f543d&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ASCO |&nbsp;\u4e2d\u56fd\u4e73\u817a\u764c\u5b66\u8005\u7684\u58f0\u97f3<\/span><\/a><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/9-1560226414.gif\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/p>\n<p style=\"white-space: normal;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/6-1560226414.png\" alt=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\" title=\"\u6211\u56fd\u7814\u7a76\u65b0\u7a81\u7834\uff1a\u73af\u72b6 RNA \u6216\u6210\u4e3a\u65b0\u7684\u809d\u764c\u6807\u5fd7\u7269\"  \/><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u662f\u5168\u7403\u4e0a\u5347\u6700\u5feb\u7684\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u75c5\u56e0\u4e4b\u4e00\uff0c\u4f46\u7531\u4e8e\u5176\u65e9\u671f\u65e0\u660e\u663e\u7279\u5f02\u6027\u75c7\u72b6\uff0c\u4ee5\u53ca\u6cbb\u7597\u9776\u70b9\u7f3a\u4e4f\uff0c\u65e9\u671f  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":114821,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114820"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=114820"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114820\/revisions"}],"predecessor-version":[{"id":114832,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/114820\/revisions\/114832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/114821"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=114820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=114820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=114820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}