{"id":115819,"date":"2019-06-11T12:25:30","date_gmt":"2019-06-11T04:24:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/115819\/"},"modified":"2019-06-11T12:24:41","modified_gmt":"2019-06-11T04:24:41","slug":"95434b2f47","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/115819\/","title":{"rendered":"\u6052\u745ePD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u7b2c\u4e8c\u9002\u5e94\u75c7\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/06\/7-1560227080.jpeg\" alt=\"\u6052\u745ePD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u7b2c\u4e8c\u9002\u5e94\u75c7\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff01\" title=\"\u6052\u745ePD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u7b2c\u4e8c\u9002\u5e94\u75c7\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff01\"  \/><\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u533b\u836f\u4e91\u7aef\u5de5\u4f5c\u5ba4\uff1a\u6316\u6398\u8d8b\u52bf\u4e2d\u7684\u4ef7\u503c<\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1a\u5b89\u8bfa\u5f71<\/span><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7ee7\u51e0\u65e5\u524d\u6052\u745e\u533b\u836f\u7684PD-1\u5355\u6297\u836f\u5361\u745e\u5229\u73e0\u7b2c\u4e00\u9002\u5e94\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u83b7\u6279\u4e4b\u540e\uff0c\u8fd1\u65e5\u8be5\u836f\u53c8\u8fce\u6765\u597d\u6d88\u606f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 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1px;\">\u6ce8\u5c04\u7528\u5361\u745e\u5229\u73e0\u5355\u6297\u662f\u4e00\u6b3e\u4eba\u6e90\u5316\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u4e0e\u4ebaPD-1\u53d7\u4f53\u7ed3\u5408\u5e76\u963b\u65adPD-1\/PD-L1\u901a\u8def\uff0c\u6062\u590d\u673a\u4f53\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b\uff0c\u4ece\u800c\u5f62\u6210\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u57fa\u7840\u3002\u6052\u745e\u533b\u836f\u7684\u8be5\u836f\u54c1\u5728\u9002\u5e94\u75c7\u6570\u91cf\u548c\u4e34\u5e8a\u6cbb\u7597\u5730\u4f4d\u4e0a\u90fd\u51f8\u663e\u51fa\u6781\u5927\u7684\u4f18\u52bf\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9002\u5e94\u75c7\u6570\u91cf\u3002\u76ee\u524d\u8be5\u836f\u54c1\u5df2\u7ecf\u67091\u4e2a\u9002\u5e94\u75c7\u83b7\u6279\uff0c1\u4e2a\u9002\u5e94\u75c7\u7533\u8bf7\u4e0a\u5e02\uff08\u5df2\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff09\uff0c6\u4e2a\u9002\u5e94\u75c7\u5904\u4e8e\u4e34\u5e8a\u4e09\u671f\uff0c\u662f\u56fd\u5185\u4f01\u4e1a\u5e03\u5c40\u9002\u5e94\u75c7\u6570\u91cf\u6700\u4e30\u5bcc\u7684PD-1\u4e4b\u4e00\uff1b<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e34\u5e8a\u6cbb\u7597\u5730\u4f4d\u3002\u8be5\u836f\u54c1\u76ee\u524d\u5904\u4e8eIII\u671f\u4e34\u5e8a\u7684\u8bd5\u9a8c\u67095\u4e2a\u5927\u764c\u79cd\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u5305\u62ec\u665a\u671f\u809d\u7ec6\u80de\u764c\u3001\u5c40\u90e8\u665a\u671f\u590d\u53d1\u6216\u8f6c\u79fb\u9f3b\u54bd\u764c\u3001IV\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u665a\u671f\u98df\u7ba1\u764c\uff0c\u9884\u8ba1\u672a\u6765\u5c06\u901a\u8fc7\u591a\u4e2a\u5927\u764c\u79cd\u7684\u4e00\u7ebf\u6cbb\u7597\u83b7\u53d6\u6781\u5927\u7684\u60a3\u8005\u7fa4\u4f53\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u56fd\u9645\u5e02\u573a\uff0c\u76ee\u524d\u5728\u809d\u7ec6\u80de\u764c\u9886\u57df\uff0cnivolumab\u548cpembrolizumab\u4e24\u6b3e\u836f\u5206\u522b\u4e8e2017\u5e749\u6708\u548c2018\u5e7411\u6708\u83b7\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\u3002\u800c\u5728\u56fd\u5185\uff0c\u76ee\u524d\u5c1a\u672a\u6709\u540c\u7c7bPD-1\/L1\u5355\u6297\u83b7\u6279\u809d\u7ec6\u80de\u764c\u9002\u5e94\u75c7\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u67e5\u8be2IMS\u6570\u636e\u5e93\uff0c2018\u5e74\u6297PD-1\u7c7b\u6297\u4f53\u5168\u7403\u9500\u552e\u989d\u7ea6\u4e3a142\u4ebf\u7f8e\u5143\uff0c\u56fd\u5185\u9500\u552e\u989d\u7ea6\u4e3a 644 \u4e07\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\">10\u5e74\u6297PD-1\u5e03\u5c40\u8fce\u6765\u6536\u83b7\u671f<\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6052\u745e\u533b\u836f\u5728\u6297PD-1\u65b9\u9762\u7684\u5e03\u5c40\u5df2\u8fd110\u5e74\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u7684\u4e34\u5e8a\u7533\u8bf7\u4e8e2015\u5e741\u6708\u8fdb\u5165CDE\u5ba1\u8bc4\u4e2d\u5fc3\u3002<span style=\"font-size: 15px;letter-spacing: 1px;\">\u622a\u81f3\u76ee\u524d\uff0c\u8be5\u4ea7\u54c1\u9879\u76ee\u5df2\u6295\u5165\u7814\u53d1\u8d39\u7528\u7ea6\u4e3a5.04\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/span>\u9996\u4e2a\u9002\u5e94\u75c7\u7684\u83b7\u6279\u6807\u5fd7\u516c\u53f8\u5df2\u8fdb\u5165\u5230\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e3b\u6218\u573a\uff0c\u540e\u7eed\u65b0\u9002\u5e94\u75c7\u4e5f\u5c06\u4e0d\u65ad\u8fce\u6765\u6536\u83b7\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2014\u5e7412\u6708\uff0c\u6052\u745e\u63d0\u4ea4\u6ce8\u5c04\u7528 SHR-1210 \u4e34\u5e8a\u6ce8\u518c\u7533\u8bf7\u5e76\u83b7\u53d7\u7406\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2016 \u5e74 2 \u6708\uff0c\u83b7\u6279\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2016\u5e7411\u6708\uff0c\u83b7\u6279\u8fdb\u884c II\u3001III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2018 \u5e74 4 \u6708 18 \u65e5\uff0c\u6052\u745e\u533b\u836f\u53ca\u5b50\u516c\u53f8\u82cf\u5dde\u76db\u8fea\u4e9a\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u3001\u4e0a\u6d77\u6052\u745e\u533b\u836f\u6709\u9650\u516c\u53f8\u9012\u4ea4\u7684\u672c\u54c1\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u83b7\u53d7\u7406\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2019\u5e745\u67085\u65e5\uff0c\u5ba1\u6279\u72b6\u6001\u8f6c\u4e3a\u201c\u5728\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u8fdb\u884c\u5ba1\u6279\u201d\u3002<\/span><\/p>\n<\/li>\n<li>\n<p 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