{"id":117459,"date":"2019-11-18T23:58:09","date_gmt":"2019-11-19T08:58:21","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/117459\/"},"modified":"2019-11-19T16:58:26","modified_gmt":"2019-11-19T08:58:26","slug":"57f358ffbb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/117459\/","title":{"rendered":"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1 style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: 1.75em;\" ><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u81eaAlnylam\u7684Onpattro\uff08patisiran\uff09\u6210\u4e3a<\/span><span style=\"color: rgb(0, 112, 192);font-size: 15px;text-decoration: underline;\">\u9996\u6b3eFDA\u6279\u51c6\u7684RNAi\u836f\u7269<\/span><span style=\"font-size: 15px;\">\u4ee5\u6765\uff0cRNAi\u5df2\u7ecf\u6210\u4e3a\u4f17\u591a\u533b\u836f\u516c\u53f8\u8003\u8651\u7684\u4e00\u79cd\u6cbb\u7597\u6a21\u5f0f\u3002\u7136\u800c\uff0c<\/span><span style=\"font-size: 15px;\">\u76ee\u524d\u5927\u591a\u5728\u7814\u7597\u6cd5\u6cbb\u7597\u7684\u75be\u75c5\u4e3a\u60a3\u8005\u4eba\u6570\u8f83\u5c11\u7684\u7f55\u89c1\u75be\u75c5\uff0c<strong>RNAi\u7597\u6cd5\u4f5c\u4e3a\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u6a21\u5f0f\uff0c\u80fd\u5426\u5b89\u5168\u6709\u6548\u5730\u5728\u5927\u4f17\u75be\u75c5\u60a3\u8005\u7fa4\u4e2d\u4f7f\u7528?<\/strong><\/span><\/section>\n<section style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\">\u4eca\u65e5\uff0cThe Medicines Company\u516c\u5e03\u4e86\u5b83\u4e0eAlnylam\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u7684RNAi\u964d\u8102\u7597\u6cd5inclisiran\uff0c\u5728\u540d\u4e3aORION-9\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8be6\u7ec6\u7ed3\u679c\u3002<\/span><strong><span style=\"font-size: 15px;\">Inclisiran\u4e0d\u4f46\u5728\u6cbb\u7597\u6742\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08HeFH\uff09\u60a3\u8005\u76843\u671f\u8bd5\u9a8c\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u7597\u6548\uff0c\u800c\u4e14\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u6ca1\u6709\u60a3\u8005\u51fa\u73b0\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u809d\u810f\u6216\u80be\u810f\u5f02\u5e38\u3002<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/section>\n<p style=\"text-align: center;\"><img class=\"rich_pages\" style=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/11\/3-1574153902.png\" alt=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\" title=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\"  \/><\/p>\n<section style=\"line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7ed3\u5408\u8be5\u516c\u53f8\u5728\u6628\u5929\u516c\u5e03\u7684ORION-10\u548c\u65e5\u524d\u516c\u5e03\u7684<\/span><span style=\"color: rgb(0, 112, 192);font-size: 15px;text-decoration: underline;\">ORION-11\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/span><span style=\"font-size: 15px;\">\uff0c<strong>inclisiran\u5df2\u7ecf\u57283\u9879\u4e0d\u540c\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027<\/strong>\u3002<\/span><span style=\"font-size: 15px;\">The Medicines Company\u8ba1\u5212\u5728\u4eca\u5e74\u7b2c\u56db\u5b63\u5ea6\u5411FDA\u9012\u4ea4\u76d1\u7ba1\u7533\u8bf7\u3002<\/span><span style=\"font-size: 15px;\">\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u8fd9\u5c06\u662f<strong>\u9996\u6b3e\u7528\u4e8e\u6cbb\u7597\u60a3\u8005\u6570\u76ee\u4f17\u591a\u7684\u5927\u4f17\u75be\u75c5\u7684RNAi\u7597\u6cd5\uff0c\u5b83\u5177\u6709\u6210\u4e3a\u91cd\u78c5\u836f\u7269\u7684\u6f5c\u529b<\/strong>\u3002<\/span><\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;white-space: normal;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\" >\n<section style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\" >\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">Inclisiran\u2014\u2014\u4e00\u5e74\u4e24\u9488\u5c31\u53ef\u964d\u4f4e\u574f\u80c6\u56fa\u9187\u7684RNAi\u7597\u6cd5<\/strong><\/span><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\" >\n<section style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;background-color: rgb(0, 112, 192);height: 1px;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Inclisiran\u662fThe Medicines Company\u548cAlnylam\u8054\u5408\u5f00\u53d1\u7684\u9996\u6b3e\u964d\u4f4e\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u7684\u521b\u65b0RNAi\u7597\u6cd5\u3002<\/span><span style=\"font-size: 15px;\">\u5b83\u76f4\u63a5\u4e0e\u7f16\u7801PCSK9\u86cb\u767d\u7684mRNA\u7ed3\u5408\uff0c\u901a\u8fc7RNA\u5e72\u6270\u4f5c\u7528\u964d\u4f4emRNA\u6c34\u5e73\uff0c\u9632\u6b62\u809d\u810f\u751f\u6210PCSK9\u86cb\u767d\u3002<\/span><span style=\"font-size: 15px;\">PCSK9\u86cb\u767d\u7684\u4f5c\u7528\u662f\u6291\u5236LDL\u53d7\u4f53\u7684\u56de\u6536\u548c\u518d\u5229\u7528\u3002<\/span><span style=\"font-size: 15px;\">\u56e0\u6b64\uff0c\u964d\u4f4ePCSK9\u86cb\u767d\u7684\u6c34\u5e73\u53ef\u4ee5\u8ba9\u66f4\u591aLDL\u53d7\u4f53\u56de\u5230\u809d\u7ec6\u80de\u8868\u9762\uff0c\u4e0e\u66f4\u591aLDL\u7ed3\u5408\uff0c\u5c06\u5b83\u4eec\u4ece\u8840\u6db2\u4e2d\u6e05\u9664\u3002<\/span><span style=\"font-size: 15px;\">\u591a\u6b3ePCSK9\u6291\u5236\u5242\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\uff0c\u800c<strong>\u8fd9\u6b3eRNAi\u7597\u6cd5\u7684\u4f18\u52bf\u5728\u4e8e\u60a3\u8005\u53ea\u9700\u8981\u6bcf\u5e74\u63a5\u53d72\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5c31\u53ef\u4ee5\u63a7\u5236\u80c6\u56fa\u9187\u6c34\u5e73\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u6b3e\u975e\u5e38\u4fbf\u6377\u7684\u6cbb\u7597\u9009\u62e9<\/strong>\u3002<\/span><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/section>\n<p style=\"text-align: center;\"><img class=\"rich_pages js_insertlocalimg\" style=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/11\/4-1574153902.jpeg\" alt=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\" title=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\"  \/><\/p>\n<section style=\"text-align: center;line-height: 1.75em;\"><strong><span style=\"color: rgb(0, 112, 192);font-size: 14px;\">\u25b2Inclisiran\u4f5c\u7528\u673a\u5236\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"color: rgb(0, 112, 192);font-size: 14px;\">\u53c2\u8003\u8d44\u6599[3]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><br  \/><\/section>\n<section style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\">\u8fd9\u6b3eRNAi\u7597\u6cd5\u4f7f\u7528\u4e86Alnylam\u516c\u53f8\u7684\u589e\u5f3a\u7a33\u5b9a\u5316\u5b66\uff08Enhanced Stabilization Chemistry\uff09-GalNAc\u9012\u9001\u6280\u672f\u5e73\u53f0\u3002<\/span><span style=\"font-size: 15px;\">\u8fd9\u4e00\u6280\u672f\u5e73\u53f0\u4e0d\u4f46\u63d0\u9ad8\u4e86RNAi\u7597\u6cd5\u7684\u7a33\u5b9a\u6027\uff0c\u800c\u4e14\u4fc3\u8fdb\u7597\u6cd5\u5411\u809d\u810f\u7684\u9776\u5411\u9012\u9001\u3002<\/span><span style=\"font-size: 15px;\">\u5bf9\u8fd9\u4e00\u9012\u9001\u6280\u672f\u7684\u4e00\u4e2a\u4e3b\u8981\u5fe7\u8651\u662fRNAi\u7597\u6cd5\u53ef\u80fd\u4ea7\u751f\u7684\u6f5c\u5728\u809d\u810f\u6bd2\u6027\u3002<\/span><strong><span style=\"font-size: 15px;\">\u7531\u4e8e\u6b64\u524dRNAi\u7597\u6cd5\u5927\u591a\u7528\u4e8e\u6cbb\u7597\u7f55\u89c1\u75c5\u60a3\u8005\uff0c\u53c2\u52a0\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4eba\u6570\u6709\u9650\uff0c\u53ef\u80fd\u4e0d\u8db3\u4ee5\u63ed\u793a\u53ef\u80fd\u51fa\u73b0\u7684\u6bd2\u526f\u4f5c\u7528<\/span><\/strong><span style=\"font-size: 15px;\">\u3002<\/span><span style=\"font-size: 15px;\">\u56e0\u6b64\u9664\u4e86\u7597\u6548\u6570\u636e\u4ee5\u5916\uff0cinclisiran\u7684\u5b89\u5168\u6027\u6570\u636e\u4e5f\u540c\u6837\u53d7\u5230\u4eba\u4eec\u7684\u5173\u6ce8\u3002<\/span><\/section>\n<p style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;clear: both;color: rgb(51, 51, 51);\"><br style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"  \/><\/p>\n<section style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;color: rgb(62, 62, 62);\">\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" >\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 10px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<section style=\"border-bottom-style: solid;border-bottom-width: 0px;border-left-color: rgb(0, 112, 192);border-left-style: solid;border-left-width: 10px;border-right-color: rgb(0, 112, 192);border-right-style: solid;border-right-width: 0px;border-top-style: solid;border-top-width: 0px;box-sizing: border-box;display: inline-block;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 5px;padding-right: 0px;padding-top: 0px;width: 638.4px;\">\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" >\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<section style=\"box-sizing: border-box;color: rgb(0, 112, 192);margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<p style=\"box-sizing: border-box;clear: both;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><span style=\"font-size: 15px;\"><strong style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">Inclisiran\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u5b89\u5168\u6027<\/strong><\/span><strong style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" >\n<section style=\"box-sizing: border-box;margin-bottom: 8px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<section style=\"background-color: rgb(0, 112, 192);box-sizing: border-box;height: 1px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;clear: both;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">The Medicines Company\u4e3a\u4e86\u68c0\u9a8cinclisiran\u7684\u964d\u8102\u7597\u6548\u548c\u5b89\u5168\u6027\u8fdb\u884c\u4e863\u9879\u968f\u673a\u53cc\u76f2\uff0c\u542b\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><span style=\"font-size: 15px;\">\u4e0b\u9762\u662finclisiran\u5728\u8fd9\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4e3b\u8981\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u3002<\/span><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/section>\n<p style=\"text-align: center;\"><img class=\"rich_pages js_insertlocalimg\" style=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/11\/0-1574153904.png\" alt=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\" title=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\"  \/><\/p>\n<section style=\"line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u9664\u6b64\u4ee5\u5916\uff0c<strong>\u5728\u4e09\u9879\u8bd5\u9a8c\u4e2d\uff0c<\/strong><strong>\u5bf9\u809d\u810f\u529f\u80fd\u548c\u80be\u810f\u529f\u80fd\u7684\u68c0\u6d4b\u90fd\u672a\u53d1\u73b0inclisiran\u8868\u73b0\u51fa\u4e0e\u5b89\u6170\u5242\u4e0d\u540c\u7684\u809d\u810f\u6216\u80be\u810f\u5f02\u5e38\u3002<\/strong><\/span><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/section>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\"><img class=\"rich_pages js_insertlocalimg\" style=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/11\/4-1574153904.jpg\" alt=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\" title=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages js_insertlocalimg\" style=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/11\/7-1574153905.jpg\" alt=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\" title=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\"  \/><\/p>\n<section style=\"text-align: center;line-height: 1.75em;\"><strong><span style=\"color: rgb(0, 112, 192);font-size: 14px;\"><span style=\"text-align: justify;text-transform: none;text-indent: 0px;letter-spacing: normal;font-family: &quot;mp-quote&quot;,-apple-system-font,BlinkMacSystemFont,&quot;Helvetica Neue&quot;,&quot;PingFang SC&quot;,&quot;Hiragino Sans GB&quot;,&quot;Microsoft YaHei UI&quot;,&quot;Microsoft YaHei&quot;,Arial,sans-serif;font-size: 14px;font-style: normal;font-variant: normal;font-weight: 400;text-decoration: none;word-spacing: 0px;display: inline !important;orphans: 2;float: none;-webkit-text-stroke-width: 0px;background-color: rgb(255, 255, 255);\">\u25b2<\/span>\u5728ORION-9\uff0c10\uff0c11\u4e2d\u5747\u672a\u53d1\u73b0\u4e0einclisiran\u76f8\u5173\u7684\u809d\u810f\u3001\u80be\u810f\u6bd2\u6027\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/span><\/strong><strong><span style=\"color: rgb(0, 112, 192);font-size: 14px;\">\u53c2\u8003\u8d44\u6599[4]\uff0c[5]\uff09<\/span><\/strong><span style=\"font-size: 15px;\"><\/span><br  \/><\/section>\n<p><br  \/><\/p>\n<section style=\"line-height: 1.75em;\"><\/section>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u6211\u5bf9inclisiran\u5728\u6240\u6709\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u7684\u6574\u4f53\u7ed3\u679c\u975e\u5e38\u6ee1\u610f\uff0c\u201dThe Medicines Company\u9996\u5e2d\u6267\u884c\u5b98Mark Timney\u5148\u751f\u8bf4\uff1a<\/span><span style=\"font-size: 15px;\">\u201c\u8fd9\u4e9b\u8bd5\u9a8c\u63d0\u4f9b\u4e86\u975e\u5e38\u4e00\u81f4\u7684\u6570\u636e\uff0c\u652f\u6301inclisiran\u4e0e\u5176\u5b83\u964d\u4f4eLDL-C\u7684\u6cbb\u7597\u624b\u6bb5\u76f8\u6bd4\uff0c\u80fd\u591f\u4e3a\u60a3\u8005\u63d0\u4f9b\u5177\u6709\u533a\u522b\u6027\u7684\u76ca\u5904\u3002<\/span><span style=\"font-size: 15px;\">\u201d<\/span><\/section>\n<p style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;clear: both;color: rgb(51, 51, 51);\"><br style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"  \/><\/p>\n<section style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;color: rgb(62, 62, 62);\">\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" >\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 10px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<section style=\"border-bottom-style: solid;border-bottom-width: 0px;border-left-color: rgb(0, 112, 192);border-left-style: solid;border-left-width: 10px;border-right-color: rgb(0, 112, 192);border-right-style: solid;border-right-width: 0px;border-top-style: solid;border-top-width: 0px;box-sizing: border-box;display: inline-block;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 5px;padding-right: 0px;padding-top: 0px;width: 638.4px;\">\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" >\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<section style=\"box-sizing: border-box;color: rgb(0, 112, 192);margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<p style=\"box-sizing: border-box;clear: both;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><span style=\"font-size: 15px;\"><strong style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">RNAi\u7597\u6cd5\u6cbb\u7597\u5927\u4f17\u75be\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f<\/strong><\/span><strong style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" >\n<section style=\"box-sizing: border-box;margin-bottom: 8px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\n<section style=\"background-color: rgb(0, 112, 192);box-sizing: border-box;height: 1px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;overflow-wrap: break-word;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;clear: both;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<section style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u591a\u5bb6\u5927\u578b\u836f\u4f01\u5df2\u7ecf\u901a\u8fc7\u4e0e\u5177\u6709RNAi\u836f\u7269\u7814\u53d1\u4e13\u957f\u7684\u516c\u53f8\u5efa\u7acb\u5408\u4f5c\u5173\u7cfb\uff0c\u8bd5\u56fe\u5229\u7528RNAi\u8fd9\u4e00\u521b\u65b0\u6cbb\u7597\u6a21\u5f0f\u6cbb\u7597\u60a3\u8005\u4eba\u6570\u4f17\u591a\u7684\u5927\u4f17\u75c5\u3002\u4f8b\u5982\uff0c\u6768\u68ee\uff08Janssen\uff09\u516c\u53f8\u53bb\u5e74\u4e0e<\/span><span style=\"color: rgb(0, 112, 192);font-size: 15px;text-decoration: underline;\">Arrowhead<\/span><span style=\"font-size: 15px;\">\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u4f7f\u7528RNAi\u6280\u672f\u5f00\u53d1\u201c\u529f\u80fd\u6027\u6cbb\u6108\u201d\u4e59\u809d\u7684\u521b\u65b0\u7597\u6cd5\u3002\u4eca\u5e7410\u6708\uff0c\u7f57\u6c0f\uff08Roche\uff09\u4e0e\u4e13\u7cbe\u4e8e\u5f00\u53d1RNAi\u7597\u6cd5\u7684Dicerna\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u5f00\u53d1<\/span><span style=\"color: rgb(0, 112, 192);font-size: 15px;text-decoration: underline;\">\u201c\u529f\u80fd\u6027\u6cbb\u6108\u201d\u4e59\u809d\u7684RNAi\u7597\u6cd5<\/span><span style=\"font-size: 15px;\">\u3002<\/span><\/section>\n<section style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\">\u53bb\u5e74\uff0c<\/span><span style=\"color: rgb(0, 112, 192);font-size: 15px;text-decoration: underline;\">Dicerna\u516c\u53f8\u4e0e\u793c\u6765\uff08Eli Lilly\uff09\u516c\u53f8\u8fbe\u6210\u7814\u53d1\u5408\u4f5c<\/span><span style=\"font-size: 15px;\">\uff0c\u5728\u5fc3\u810f\u4ee3\u8c22\u75be\u75c5\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u75bc\u75db\u9886\u57df\u5f00\u53d1\u6f5c\u5728RNAi\u7597\u6cd5\u3002\u800c\u4eca\u65e5\uff0c\u8be5\u516c\u53f8\u53c8\u4e0e\u8bfa\u548c\u8bfa\u5fb7\uff08Novo Nordisk\uff09\u8fbe\u6210\u534f\u8bae\uff0c\u5229\u7528\u8be5\u516c\u53f8\u7684GalXC\u6280\u672f\u5e73\u53f0\uff0c\u5f00\u53d1\u4e0e\u809d\u810f\u76f8\u5173\u7684\u5fc3\u810f\u4ee3\u8c22\u75be\u75c5\u3002<strong>\u8fd9\u4e9b\u75be\u75c5\u5305\u62ec\u6162\u6027\u809d\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\uff0c2\u578b\u7cd6\u5c3f\u75c5\uff0c\u80a5\u80d6\u75c7<\/strong>\uff0c\u4ee5\u53ca\u7f55\u89c1\u75c5\u3002\u8bfa\u548c\u8bfa\u5fb7\u4e3a\u8fd9\u9879\u534f\u8bae\u5c06\u652f\u4ed82.25\u4ebf\u7f8e\u5143\u7684\u524d\u671f\u4ed8\u6b3e\u548c\u80a1\u6743\u6295\u8d44\u3002<\/span><\/section>\n<section style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\">\u6210\u529f\u5f00\u53d1\u9996\u6b3e\u83b7\u6279RNAi\u7597\u6cd5\u7684Alynlam\u516c\u53f8\u4eca\u5e74\u4e5f\u4e0e\u518d\u751f\u5143\uff08Regeneron\uff09\u516c\u53f8\u8fbe\u621010\u4ebf\u7f8e\u5143\u7684<\/span><span style=\"color: rgb(0, 112, 192);font-size: 15px;text-decoration: underline;\">\u7814\u53d1\u534f\u8bae<\/span><span style=\"font-size: 15px;\">\uff0c\u8fdb\u4e00\u6b65\u6269\u5c55RNAi\u7597\u6cd5\u7684\u4f7f\u7528\u8303\u56f4\u3002<\/span><\/section>\n<section style=\"line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\">\u8fd9\u4e9b\u7814\u53d1\u5408\u4f5c\u8868\u660e\uff0c<strong>RNAi\u7597\u6cd5\u8fd9\u4e00\u6cbb\u7597\u6a21\u5f0f\u4e0d\u4f46\u5f97\u5230\u5927\u578b\u836f\u4f01\u7684\u8ba4\u53ef\uff0c\u800c\u4e14\u53ef\u80fd\u4e3a\u6cbb\u7597\u591a\u79cd\u5927\u4f17\u75c5\u63d0\u4f9b\u65b0\u7684\u9009\u62e9<\/strong>\u3002<\/span><span style=\"font-size: 15px;\">\u800c\u4eca\u65e5inclisiran\u5728\u591a\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8868\u73b0\u51fa\u7684\u826f\u597d\u5b89\u5168\u6027\uff0c\u4e3a\u6269\u5c55RNAi\u7597\u6cd5\u7684\u5e94\u7528\u8303\u56f4\u63d0\u4f9b\u4e86\u66f4\u591a\u6709\u529b\u8bc1\u636e\u3002<\/span><span style=\"font-size: 15px;\">\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u521b\u65b0\u6cbb\u7597\u6a21\u5f0f\u80fd\u591f\u4e3a\u5e7f\u5927\u60a3\u8005\u9020\u798f\u3002<\/span><\/section>\n<p><br  \/><\/p>\n<section style=\"line-height: 1.75em;\"><\/section>\n<p style=\"line-height: normal;\"><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><br  \/><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">[1] The Medicines Company Announces that the ORION-10 Study of Inclisiran in ASCVD Patients Showed Durable and Potent Lowering of LDL-C with Twice-Yearly Dosing. Retrieved November 18, 2019, from https:\/\/www.businesswire.com\/news\/home\/20191116005001\/en<\/span><br  \/><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">[2] The Medicines Company Announces that the ORION-9 Study of Inclisiran in HeFH Patients Showed Durable and Potent LDL-C Lowering with Twice-Yearly Dosing. Retrieved November 18, 2019, from https:\/\/www.themedicinescompany.com\/investor\/pr\/4152740\/<\/span><br  \/><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">[3] Kosmas et al, (2018). Inclisiran: A New Promising Agent in the Management of Hypercholesterolemia. Diseases, https:\/\/doi.org\/10.3390\/diseases6030063<\/span><br  \/><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">[4] ORION-9 &amp; 10 Investor Conference Call. Retrieved November 18, 2019, from https:\/\/www.themedicinescompany.com\/media\/2019-11-18_AHA_MDCO_IR_Event_Slides_FINAL.pdf<\/span><br  \/><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">[5] European Society of Cardiology (ESC) Congress ORION-11 Investor Conference Call. Retrieved November 18, 2019, from https:\/\/www.themedicinescompany.com\/media\/slides_020919_ESC-ORION-11-analyst-call_Paris.pdf<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: normal;\"><span style=\"color: rgb(178, 178, 178);letter-spacing: 0.54px;font-family: -apple-system-font,BlinkMacSystemFont,&quot;Helvetica Neue&quot;,&quot;PingFang SC&quot;,&quot;Hiragino Sans GB&quot;,&quot;Microsoft YaHei UI&quot;,&quot;Microsoft YaHei&quot;,Arial,sans-serif;font-size: 10px;background-color: rgb(255, 255, 255);\">\u7248\u6743\u8bf4\u660e\uff1a\u672c\u6587\u6765\u81ea\u5185\u5bb9\u56e2\u961f\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u81f3\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u5a92\u4f53\u6216\u673a\u6784\u672a\u7ecf\u6388\u6743\u4ee5\u4efb\u4f55\u5f62\u5f0f\u8f6c\u8f7d\u81f3\u5176\u4ed6\u5e73\u53f0\u3002\u8f6c\u8f7d\u6388\u6743\u8bf7\u5728\u300c\u300d\u5fae\u4fe1\u516c\u4f17\u53f7\u56de\u590d\u201c\u8f6c\u8f7d\u201d\uff0c\u83b7\u53d6\u8f6c\u8f7d\u987b\u77e5\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;white-space: normal;\"><img class=\"__bg_gif\" style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 640px !important;\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/11\/1-1574153906.gif\" alt=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\" title=\"\u8fd9\u4e00\u201c\u8bfa\u5956\u6280\u672f\u201d\u6cbb\u7597\u5927\u4f17\u75c5\u7684\u65f6\u4ee3\u5373\u5c06\u6765\u4e34\uff1f\u9996\u6b3e\u964d\u8102RNAi\u7597\u6cd5\u6709\u671b\u660e\u5e74\u83b7\u6279\"  \/><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u81eaAlnylam\u7684Onpattro\uff08patisiran\uff09\u6210\u4e3a\u9996\u6b3eFDA\u6279\u51c6\u7684RNAi\u836f\u7269\u4ee5\u6765 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":117460,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/117459"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=117459"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/117459\/revisions"}],"predecessor-version":[{"id":117467,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/117459\/revisions\/117467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/117460"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=117459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=117459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=117459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}