{"id":117782,"date":"2019-06-13T22:54:50","date_gmt":"2020-04-20T09:52:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/117782\/"},"modified":"2020-04-20T17:52:59","modified_gmt":"2020-04-20T09:52:59","slug":"a31fc9901e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/117782\/","title":{"rendered":"\u827e\u6ecb\u75c5\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u5fd7\u613f\u8005\uff0c\u9662\u65b9\uff1a\u75ab\u82d7\u4e0d\u4f1a\u4f7f\u53d7\u8bd5\u8005\u611f\u67d3 HIV | \u4e01\u9999\u65e9\u8bfb"},"content":{"rendered":"
\n
<\/section>\n

\"\u827e\u6ecb\u75c5\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u5fd7\u613f\u8005\uff0c\u9662\u65b9\uff1a\u75ab\u82d7\u4e0d\u4f1a\u4f7f\u53d7\u8bd5\u8005\u611f\u67d3<\/span><\/strong><\/p>\n


<\/p>\n

\n
\n
\n

\u6bcf\u4e2a\u5de5\u4f5c\u65e5\u65e9\u6668<\/span><\/p>\n

\u4e01\u9999\u65e9\u8bfb<\/span><\/strong> <\/span>\u51c6\u65f6\u66f4\u65b0<\/span><\/span><\/p>\n

\u7b2c\u4e00\u65f6\u95f4 \u8ffd\u8e2a\u533b\u7597\u70ed\u70b9<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n

\u827e\u6ecb\u75c5\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u5fd7\u613f\u8005\uff0c\u9662\u65b9\uff1a\u75ab\u82d7\u4e0d\u4f1a\u4f7f\u53d7\u8bd5\u8005\u611f\u67d3 HIV<\/strong><\/span><\/p>\n


<\/span><\/p>\n

6 \u6708 5 \u65e5\uff0c\u4e2d\u56fd\u75be\u63a7\u4e2d\u5fc3\u53d1\u5e03\u6d88\u606f\u79f0\uff0c\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u827e\u6ecb\u75c5\u5019\u9009\u75ab\u82d7<\/span>\uff08DNA-rTV\uff09<\/span>\u5728\u5317\u4eac\u4f51\u5b89\u533b\u9662\u548c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8ba1\u5212\u62db\u52df 160 \u540d HIV \u9634\u6027\u5065\u5eb7\u5fd7\u613f\u8005\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u827e\u6ecb\u75c5\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u5fd7\u613f\u8005\uff0c\u9662\u65b9\uff1a\u75ab\u82d7\u4e0d\u4f1a\u4f7f\u53d7\u8bd5\u8005\u611f\u67d3<\/p>\n

<\/span>\u56fe\u6e90\uff1a\u4e2d\u56fd\u75be\u63a7\u4e2d\u5fc3\u7f51\u7ad9\u622a\u56fe<\/span><\/p>\n


<\/p>\n

\u8be5\u8bd5\u9a8c\u83b7\u5f97\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff0c\u5e76\u7ecf\u8fc7\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u4f51\u5b89\u533b\u9662\u548c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\u3002\u6b64\u524d\u5df2\u5b8c\u6210\u4e86 l \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f51\u5b89\u533b\u9662\u8ba1\u5212\u62db\u52df 104 \u540d\u5fd7\u613f\u8005\uff0c\u6d59\u5927\u4e00\u9662\u8ba1\u5212\u62db\u52df 56 \u540d\u5fd7\u613f\u8005\uff0c\u8bd5\u9a8c\u5468\u671f\u6839\u636e\u4e2a\u4eba\u60c5\u51b5\u6700\u77ed\u4e3a 88 \u5468\uff0c\u6700\u957f\u4e3a 112 \u5468\u3002\u8bd5\u9a8c\u83b7\u5f97\u7684\u4fe1\u606f\u5c06\u63d0\u4f9b\u7ed9\u827e\u6ecb\u75c5\u75ab\u82d7\u7684\u7814\u53d1\u5de5\u4f5c\u3002\u53c2\u4e0e\u6574\u4e2a\u9879\u76ee\u7684\u53d7\u8bd5\u8005\u5c06\u6bcf\u4eba\u5f97\u5230 15,000 \u5143\u7684\u8865\u52a9\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5173\u4e8e\u6ce8\u5c04\u827e\u6ecb\u75c5\u75ab\u82d7\u540e\uff0c\u4f1a\u4e0d\u4f1a\u6709\u611f\u67d3 HIV \u7684\u98ce\u9669\u3002\u9662\u65b9\u89e3\u91ca\uff0c\u827e\u6ecb\u75c5\u75ab\u82d7\u4e0d\u542b\u5b8c\u6574\u7684 HIV\uff0c\u662f\u7531\u75d8\u82d7\u75c5\u6bd2\u8f7d\u4f53\u643a\u5e26 HIV \u57fa\u56e0\u7247\u6bb5\u6784\u6210\uff0c\u75ab\u82d7\u63a5\u79cd\u672c\u8eab\u4e0d\u4f1a\u4f7f\u53d7\u8bd5\u8005\u611f\u67d3 HIV\u3002<\/span>\uff08\u6d59\u6c5f\u5728\u7ebf\uff09<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n

FDA \u4f7f\u7528\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u652f\u6301\u4eff\u5236\u836f\u6279\u51c6\uff0c\u53ef\u4ee3\u66ff\u4f53\u5185\u7814\u7a76<\/strong><\/span><\/p>\n


<\/span><\/p>\n

6 \u6708 13 \u65e5\uff0cCertara \u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u540d\u4e3a Simcyp \u7684\u57fa\u4e8e\u751f\u7406\u5b66\u7684\u836f\u4ee3\u52a8\u529b\u5b66<\/span>\uff08PBPK\uff09<\/span>\u6a21\u62df\u6280\u672f\uff0c\u9996\u6b21\u88ab\u7f8e\u56fd FDA \u6279\u51c6\u7528\u4e8e\u5728\u590d\u6742\u4eff\u5236\u836f\u7684\u8fc7\u7a0b\u4e2d\u8bc1\u660e\u751f\u7269\u7b49\u6548\u6027<\/span>\uff08BE\uff09<\/span>\uff0c\u4ee3\u66ff\u4e86\u4f53\u5185\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728\u4eff\u5236\u836f\u7684\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0cBE \u7814\u7a76\u7684\u76ee\u7684\u662f\u786e\u4fdd\u63a5\u53d7\u68c0\u6d4b\u7684\u836f\u7269\u4ea7\u54c1\u7684\u5438\u6536\u901f\u5ea6\u548c\u6c34\u5e73\u4e0e\u6807\u51c6\u836f\u7269\u4ea7\u54c1\u76f8\u4f3c\u3002<\/span><\/p>\n


<\/span><\/p>\n

Simcyp \u6a21\u62df\u8f6f\u4ef6\u7528\u4e8e\u786e\u5b9a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u65f6\u7684\u7528\u836f\u5242\u91cf\u3001\u4f18\u5316\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u3001\u8bc4\u4f30\u65b0\u7684\u836f\u7269\u914d\u65b9\u548c\u9884\u6d4b\u836f\u7269\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002PBPK \u80fd\u591f\u63cf\u8ff0\u836f\u7269\u5728\u4e0d\u540c\u4eba\u4f53\u7ec4\u7ec7\u4e2d\u7684\u8868\u73b0\u3002\u8fd9\u4e00\u6a21\u62df\u8f6f\u4ef6\u5df2\u7ecf\u4e3a 50 \u79cd\u521b\u65b0\u836f\u7269\u7533\u8bf7\u63d0\u4f9b\u4fe1\u606f\u3002<\/span>\uff08\u6765\u6e90\uff1a\uff09<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n

\u5317\u4eac\u536b\u5065\u59d4\uff1a\u4f18\u5316\u95e8\u8bca\u5c31\u8bca\u73af\u5883\uff0c\u6301\u7eed\u63a8\u5e7f\u300c\u4e00\u533b\u4e00\u60a3\u300d\u6a21\u5f0f<\/strong><\/span><\/p>\n


<\/span><\/p>\n

6 \u6708 12 \u65e5\uff0c\u5317\u4eac\u5e02\u536b\u5065\u59d4\u65b0\u95fb\u53d1\u8a00\u4eba\u4ecb\u7ecd\uff0c\u5317\u4eac\u5e02\u5c06\u63a8\u8fdb\u6539\u5584\u533b\u7597\u670d\u52a1\u3001\u89c4\u8303\u670d\u52a1\u884c\u4e3a\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5317\u4eac\u5e02\u536b\u5065\u59d4\u4e3b\u4efb\u96f7\u6d77\u6f6e\u4ecb\u7ecd\uff0c\u4eca\u5e74\u300c\u4e00\u533b\u4e00\u60a3\u300d\u6a21\u5f0f\u5c06\u6301\u7eed\u63a8\u5e7f\u3002\u4e0d\u5c11\u533b\u9662\u8fd8\u5b58\u5728\u5927\u91cf\u60a3\u8005\u6324\u5728\u4e00\u4f4d\u533b\u751f\u8bca\u684c\u524d\u7684\u95ee\u9898\u3002\u6839\u636e\u300a\u884c\u52a8\u8ba1\u5212\u300b\uff0c\u4eca\u5e74\uff0c\u533b\u9662\u8981\u52a0\u5f3a\u60a3\u8005\u9690\u79c1\u4fdd\u62a4\uff0c\u4f18\u5316\u758f\u5bfc\u7ba1\u7406\u63aa\u65bd\uff0c\u5c3d\u529b\u907f\u514d\u591a\u540d\u60a3\u8005\u540c\u65f6\u5728\u540c\u4e00\u8bca\u5ba4\u5185\u5019\u8bca\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728\u4f18\u5316\u95e8\u8bca\u5c31\u8bca\u73af\u5883\u65b9\u9762\uff0c\u4e94\u73af\u5185\u7684\u4e09\u7ea7\u533b\u9662\u8981\u5408\u7406\u8c03\u6574\u6bcf\u65e5\u4e0a\u4e0b\u5348\u51fa\u8bca\u5355\u5143\u7684\u6bd4\u4f8b\uff0c\u914c\u60c5\u589e\u52a0\u4e0b\u5348\u51fa\u8bca\u533b\u751f\u6570\u91cf\u3002\u539f\u5219\u4e0a\u4e09\u7ea7\u7efc\u5408\u533b\u9662\u5168\u90e8\u5f00\u5c55\u77e5\u540d\u4e13\u5bb6\u56e2\u961f\u670d\u52a1\uff0c\u5317\u4eac\u77e5\u540d\u4e13\u5bb6\u56e2\u961f\u6570\u91cf\u8fbe\u5230 200 \u4e2a\u5de6\u53f3\u3002\u4e8c\u7ea7\u4ee5\u4e0a\u533b\u9662\u5168\u90e8\u5f00\u8bbe\u836f\u5b66\u670d\u52a1\u95e8\u8bca\u6216\u7528\u836f\u54a8\u8be2\u7a97\u53e3\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e2a\u6027\u5316\u7684\u5408\u7406\u7528\u836f\u6307\u5bfc\u3002<\/span>\uff08\u6765\u6e90\uff1a\u65b0\u4eac\u62a5\uff09<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n

\u56fd\u4ea7 PD-1 \u5361\u745e\u5229\u73e0\u5355\u6297\u5b9a\u4ef7 19,800 \u5143<\/strong><\/span><\/p>\n


<\/span><\/p>\n

6 \u6708 12 \u65e5\u4e0b\u5348\uff0c\u6052\u745e\u533b\u836f PD-1<\/span>\uff08\u5361\u745e\u5229\u73e0\u5355\u6297\uff09<\/span>\u5b9a\u4ef7\u4fe1\u606f\u6d41\u51fa\uff0c\u89c4\u683c\u4e3a 200mg \u7684\u836f\u7269\u6700\u7ec8\u5b9a\u4ef7\u4e3a 19,800 \u5143\/\u74f6\u3002\u8be5\u836f\u9002\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u81f3\u6b64\uff0c\u56fd\u5185\u5df2\u4e0a\u5e02\u7684 5 \u4e2a PD-1 \u5355\u6297\u5b9a\u4ef7\u5168\u90e8\u516c\u5e03\uff0c\u5361\u745e\u5229\u73e0\u5355\u6297\u4e5f\u6210\u4e3a\u6240\u6709\u56fd\u4ea7 PD-1 \u4e2d\u6700\u8d35\u7684\u3002\u4e0d\u8fc7\u4e5f\u6709\u4e1a\u5185\u4eba\u58eb\u6307\u51fa\uff0c\u7531\u4e8e\u6052\u745e\u533b\u836f\u5c1a\u672a\u516c\u5e03\u7528\u6cd5\u7528\u91cf\u53ca\u8d60\u836f\u65b9\u6848\uff0c\u6700\u7ec8\u7684\u5e74\u6cbb\u7597\u8d39\u7528\u4ecd\u672a\u6700\u7ec8\u786e\u5b9a\u3002<\/span>\uff08\u6765\u6e90\uff1a\u65b0\u4eac\u62a5\uff09<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n

\u4e16\u536b\u7ec4\u7ec7\uff1a\u57c3\u535a\u62c9\u75c5\u6bd2\u5df2\u7531\u521a\u679c\uff08\u91d1\uff09\u6269\u6563\u5230\u4e4c\u5e72\u8fbe<\/strong><\/span><\/p>\n


<\/span><\/p>\n

\u4e16\u754c\u536b\u751f\u7ec4\u7ec7 6 \u6708 11 \u65e5\u8868\u793a\uff0c\u57c3\u535a\u62c9\u51fa\u8840\u70ed\u5df2\u7ecf\u7531\u521a\u679c\u6c11\u4e3b\u5171\u548c\u56fd\u6269\u6563\u5230\u90bb\u56fd\u4e4c\u5e72\u8fbe\uff0c\u6709\u4e00\u540d 5 \u5c81\u513f\u7ae5\u611f\u67d3\u4e86\u57c3\u535a\u62c9\u3002<\/span><\/p>\n


<\/span><\/p>\n

6 \u6708 9 \u65e5\uff0c\u8fd9\u540d 5 \u5c81\u513f\u7ae5\u548c\u5bb6\u4eba\u4e00\u8d77\u4ece\u521a\u679c<\/span>\uff08\u91d1\uff09<\/span>\u6765\u5230\u4e4c\u5e72\u8fbe\u65c5\u6e38\u3002\u4e0d\u4e45\u4ed6\u51fa\u73b0\u57c3\u535a\u62c9\u75c5\u6bd2\u611f\u67d3\u75c7\u72b6\uff0c\u88ab\u9001\u5f80\u4e4c\u5e72\u8fbe\u5361\u585e\u585e\u5730\u533a\u57c3\u535a\u62c9\u51fa\u8840\u70ed\u6cbb\u7597\u4e2d\u5fc3\u9694\u79bb\u6cbb\u7597\u300211 \u65e5\uff0c\u4e4c\u5e72\u8fbe\u75c5\u6bd2\u7814\u7a76\u6240\u786e\u8ba4\u8fd9\u540d\u513f\u7ae5\u611f\u67d3\u57c3\u535a\u62c9\u51fa\u8840\u70ed\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e4c\u5e72\u8fbe\u536b\u751f\u90e8\u8868\u793a\uff0c\u4ed6\u4eec\u548c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5df2\u5411\u4e4c\u5e72\u8fbe\u5361\u585e\u585e\u5730\u533a\u6d3e\u9063\u4e86\u4e00\u4e2a\u5feb\u901f\u53cd\u5e94\u5c0f\u7ec4\uff0c\u4ee5\u786e\u5b9a\u53ef\u80fd\u9762\u4e34\u611f\u67d3\u7684\u4eba\u7fa4\uff0c\u5e76\u786e\u4fdd\u8fd9\u4e9b\u4eba\u80fd\u53ca\u65f6\u5f97\u5230\u9694\u79bb\u6cbb\u7597\u3002\u540c\u65f6\uff0c\u536b\u751f\u90e8\u95e8\u8fd8\u4e3a\u90a3\u4e9b\u63a5\u89e6\u8fc7\u75c5\u4eba\u4ee5\u53ca\u76f8\u5173\u7684\u533b\u62a4\u5de5\u4f5c\u8005\u63a5\u79cd\u4e86\u75ab\u82d7\u3002<\/span><\/p>\n


<\/span><\/p>\n

6 \u6708 12 \u65e5\uff0c\u4e16\u536b\u7ec4\u7ec7\u58f0\u660e\uff0c\u786e\u8bca\u611f\u67d3\u57c3\u535a\u62c9\u75c5\u6bd2\u7684 5 \u5c81\u7537\u7ae5\u5df2\u7ecf\u4e8e 11 \u65e5\u665a\u6b7b\u4ea1\uff1b\u53e6\u5916\u6709\u4e24\u4eba\u57c3\u535a\u62c9\u75c5\u6bd2\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\uff0c\u4e4c\u5e72\u8fbe\u57c3\u535a\u62c9\u75c5\u6bd2\u786e\u8bca\u611f\u67d3\u8005\u589e\u52a0\u81f3 3 \u4eba\u3002<\/span>\uff08\u6765\u6e90\uff1a\u65b0\u534e\u793e\uff09<\/span><\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n

\u7b2c <\/span>207<\/strong><\/span> \u671f\u4e01\u9999\u65e9\u8bfb\u5230\u6b64\u7ed3\u675f<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u8d23\u4efb\u7f16\u8f91\uff1a\u5468\u60a6<\/span><\/p>\n

\u9898\u56fe\u6765\u6e90\uff1a<\/span>\u7ad9\u9177\u6d77\u6d1b<\/span><\/p>\n


<\/p>\n

\"\u827e\u6ecb\u75c5\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u5fd7\u613f\u8005\uff0c\u9662\u65b9\uff1a\u75ab\u82d7\u4e0d\u4f1a\u4f7f\u53d7\u8bd5\u8005\u611f\u67d3<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6bcf\u4e2a\u5de5\u4f5c\u65e5\u65e9\u6668 \u4e01\u9999\u65e9\u8bfb \u51c6\u65f6\u66f4\u65b0 \u7b2c\u4e00\u65f6\u95f4 \u8ffd\u8e2a\u533b\u7597\u70ed\u70b9 \u827e\u6ecb\u75c5\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u5fd7\u613f\u8005\uff0c\u9662\u65b9\uff1a\u75ab\u82d7 […]<\/p>\n","protected":false},"author":1,"featured_media":117783,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/117782"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=117782"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/117782\/revisions"}],"predecessor-version":[{"id":117788,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/117782\/revisions\/117788"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/117783"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=117782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=117782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=117782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}