{"id":119061,"date":"2019-07-10T11:55:50","date_gmt":"2020-04-20T10:04:36","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/119061\/"},"modified":"2020-04-20T18:04:37","modified_gmt":"2020-04-20T10:04:37","slug":"b7b4bdfaee","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/119061\/","title":{"rendered":"\u5173\u6ce8 | \u55b9\u8bfa\u916e\u5bb6\u65cf\u7684\u65b0\u6210\u5458\u2014\u2014\u82f9\u679c\u9178\u5948\u8bfa\u6c99\u661f"},"content":{"rendered":"
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\u5948\u8bfa\u6c99\u661f\u53e3\u670d\u5236\u5242\u5728 CAP \u60a3\u8005\u4e2d\u5f00\u5c55\u7684 2 \u9879\u63a2\u7d22\u6027\u4e34\u5e8a\u8bd5\u9a8c (\u2161\u671f) \u548c 1 \u9879\u786e\u8bc1\u6027\u8bd5\u9a8c (\u2162\u671f) \u4ea6\u663e\u793a\u8be5\u836f\u4e0d\u826f\u53cd\u5e94\u5c11\u800c\u8f7b\u5fae, \u60a3\u8005\u8010\u53d7\u6027\u826f\u597d\u3002<\/span>\u672a\u53d1\u73b0\u76ae\u80a4\u5149\u6bd2\u6027\u3001\u660e\u663e\u7684\u809d\u6bd2\u6027\u3001\u81f4\u75c9\u631b\u7b49\u4e25\u91cd\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u548c\u5916\u5468\u795e\u7ecf\u6bd2\u6027\u548c\u9057\u4f20\u6bd2\u6027\u3002<\/span>TQT \u8bd5\u9a8c\u8bc1\u660e\u5948\u8bfa\u6c99\u661f\u65e0\u660e\u663e\u5fc3\u7535\u56fe QT \u95f4\u671f\u5ef6\u957f\uff0c\u5fc3\u810f\u5b89\u5168\u6027\u4f18\u4e8e\u83ab\u897f\u6c99\u661f\u3002<\/span>\uff3b8\uff3d<\/sup><\/span><\/p>\n


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\u5948\u8bfa\u6c99\u661f\u901a\u8fc7\u7ed3\u6784\u7684\u6539\u826f\uff0c\u4fdd\u7559\u4e86\u4f20\u7edf\u55b9\u8bfa\u916e\u7684\u4f18\u52bf\uff0c\u89c4\u907f\u4e86\u6f5c\u5728\u9690\u60a3\uff0c\u6839\u636e\u56fd\u5bb6\u9f13\u52b1\u521b\u65b0\u836f\u7684\u653f\u7b56\uff0c\u5982\u80fd\u987a\u5229\u8fdb\u5165\u533b\u4fdd\u76ee\u5f55\uff0c\u5948\u8bfa\u6c99\u661f\u5c06\u662f\u6cbb\u7597\u793e\u533a\u547c\u5438\u9053\u611f\u67d3\u7684\u91cd\u8981\u6297\u83cc\u836f\u7269\u4e4b\u4e00\u3002<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n

[1] 2018 \u5e74 1 \u6708\u6297\u83cc\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u76d1\u6d4b\u7f51\u7edf\u8ba1\u6570\u636e<\/p>\n

[2] \u80e1\u851a\u840d, \u5f20\u9759, \u77bf\u4ecb\u660e. \u5948\u8bfa\u6c99\u661f\u5728\u793e\u533a\u83b7\u5f97\u6027\u80ba\u708e\u6297\u83cc\u6cbb\u7597\u4e2d\u7684\u4ef7\u503c[J]. \u4e2d\u534e\u7ed3\u6838\u548c\u547c\u5438\u6742\u5fd7, 2017, 40(10):775-777.<\/span><\/p>\n

[3] \u82d7\u8d1d\u8d1d, \u6881\u84d3\u84d3, \u738b\u777f, \u7b49. \u65b0\u578b\u65e0\u6c1f\u55b9\u8bfa\u916e\u7c7b\u836f\u7269\u5948\u8bfa\u6c99\u661f\u7684\u7814\u7a76\u8fdb\u5c55[J]. \u4e2d\u56fd\u533b\u9662\u7528\u836f\u8bc4\u4ef7\u4e0e\u5206\u6790, 2016, 16(11):1577-1580.<\/span><\/p>\n

[4] \u6731\u5fb7\u59b9, \u5434\u57f9\u6f84, \u80e1\u4ed8\u54c1,\u7b49. \u5948\u8bfa\u6c99\u661f\u4f53\u5916\u6297\u83cc\u4f5c\u7528\u7814\u7a76[J]. \u4e2d\u56fd\u611f\u67d3\u4e0e\u5316\u7597\u6742\u5fd7, 2015, 15(2):97-112.<\/span><\/p>\n

[5] Tan C K, Lai C C, Liao C H, et al. Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and other quinolones against clinical isolates of Mycobacterium tuberculosis[J]. J Antimicrob Chemother, 2009, 64(2):428-429.<\/span><\/p>\n

[6] Lin L, Chang LW, Tsai CY, et al.Dose escalation study of the safety, tolerability, and pharmacokinetics of nemonoxacin (TG-873870), a novel potent broad-spectrum nonfluorinated quinolone, in healthy volunteers. Antimicrob Agents Chemother. 2010;54(1):405-410.
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[7] Guo B, Wu X, Zhang Y, et al.Safety and clinical pharmacokinetics of nemonoxacin, a novel non-fluorinated quinolone, in healthy Chinese volunteers following single and multiple oral doses. Clin Drug Investig. 2012;32(7):475-486.<\/p>\n

[8] Caiyun Zhao\uff0cEffects of Nemonoxacin on Thorough ECG  QT\/QTc Interval Clinical Therapeutics Volume40\uff0cNumber 6\uff0c2018<\/p>\n<\/section>\n<\/section>\n<\/section>\n


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