{"id":119963,"date":"2019-07-30T11:50:50","date_gmt":"2020-04-20T10:13:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/119963\/"},"modified":"2020-04-20T18:13:06","modified_gmt":"2020-04-20T10:13:06","slug":"14c855a838","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/119963\/","title":{"rendered":"\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff1a\u65b0\u7248\u6b27\u6d32\/\u7f8e\u56fd\u6162\u4e59\u809d\u6307\u5357\u63a8\u8350\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"box-sizing: border-box;font-size: 16px;\">\n<section style=\"margin-top: 20px;margin-bottom: 20px;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\" >\n<section style=\"transform: rotate(3deg);-webkit-transform: rotate(3deg);-moz-transform: rotate(3deg);-o-transform: rotate(3deg);box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: transparent;background-color: rgb(141, 205, 227);box-sizing: border-box;\">\n<section style=\"transform: rotate(-3deg);-webkit-transform: rotate(-3deg);-moz-transform: rotate(-3deg);-o-transform: rotate(-3deg);box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(174, 186, 191);width: 100%;padding: 10px;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 1px;padding-right: 20px;padding-left: 20px;box-sizing: border-box;\" >\n<p style=\"white-space: normal;box-sizing: border-box;\">2018 \u5e74 9 \u6708\uff0cJAMA Oncology \u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u97e9\u56fd\u7684\u4e00\u9879<span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76<\/span><sup style=\"max-width: 100%;letter-spacing: 1px;white-space: normal;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;[1]<\/sup>\uff0c\u6587\u7ae0\u4e00\u7ecf\u53d1\u8868\uff0c\u300c\u4e00\u77f3\u6fc0\u8d77\u5343\u5c42\u6d6a\u300d\uff0c\u7acb\u5373\u5f15\u53d1\u4e86\u70ed\u8bae\u3002\u6bd5\u7adf\uff0c\u809d\u764c\u4e24\u4e2a\u5b57\u8fc7\u4e8e\u6c89\u91cd\u3002\u6211\u4eec\u5982\u4f55\u770b\u5f85\u8fd9\u9879\u7814\u7a76\u5462\uff1f\u300a\u56fd\u9645\u809d\u75c5\u300b\u9080\u8bf7\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5730\u575b\u533b\u9662\u8c22\u5c27\u6559\u6388\u5bf9\u6b64\u8fdb\u884c\u4e86\u89e3\u8bfb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" >\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2020\/04\/6-1587377585.jpg\" alt=\"\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff1a\u65b0\u7248\u6b27\u6d32\/\u7f8e\u56fd\u6162\u4e59\u809d\u6307\u5357\u63a8\u8350\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\" title=\"\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff1a\u65b0\u7248\u6b27\u6d32\/\u7f8e\u56fd\u6162\u4e59\u809d\u6307\u5357\u63a8\u8350\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\"  \/><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<p style=\"text-align: center;\">\n<div class=\"bp-video\">\n<div class=\"player\">\n                    <iframe class=\"bp-iframe\" width=\"100%\" src=\"https:\/\/v.qq.com\/iframe\/preview.html?&amp;&amp;auto=0&amp;vid=w0765799yfe\" frameborder=\"0\" allowfullscreen=\"true\"><\/iframe>\n                <\/div>\n<\/div>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;text-align: center;box-sizing: border-box;\" >\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"border-top: 2px dotted rgb(95, 94, 102);width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(0, 193, 218);color: rgb(255, 255, 255);padding-left: 5px;padding-right: 5px;margin-top: 4px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u7814\u7a76\u4e3b\u8981\u5185\u5bb9<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 1px;padding-right: 20px;padding-left: 20px;box-sizing: border-box;\" >\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u65b9\u6cd5\u6982\u8ff0<\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8be5\u6587\u7ae0\u5305\u62ec\u4e86\u4e24\u9879\u56de\u987e\u6027\u961f\u5217\u5206\u6790\uff0c\u4e00\u9879\u57fa\u4e8e\u56fd\u5bb6\u6570\u636e\u5e93\u5c42\u9762\u7684\u5386\u53f2\u4eba\u7fa4\u961f\u5217\u7814\u7a76\uff0c\u53e6\u4e00\u9879\u5219\u662f\u5728\u533b\u9662\u961f\u5217\u4e2d\u7684\u7ed3\u679c\u9a8c\u8bc1\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5386\u53f2\u961f\u5217\u7814\u7a76\u5171\u7eb3\u5165 24156 \u4f8b\u521d\u6cbb\u6210\u4eba\u6162\u4e59\u809d\u75c5\u4f8b\uff0c\u6069\u66ff\u5361\u97e6\uff08ETV\uff09\u6cbb\u7597\u7ec4 11 464 \u4f8b\uff0c\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u4e8c\u5421\u544b\u916f\uff08TDF\uff09\u6cbb\u7597\u7ec4 12 692 \u4f8b\uff0c\u8d44\u6599\u6765\u81ea\u97e9\u56fd\u56fd\u5bb6\u533b\u7597\u4fdd\u9669\uff08NHIS\uff09\u7684\u58f0\u660e\u6570\u636e\u5e93\uff08NHIS \u8986\u76d6\u4e86 90% \u4ee5\u4e0a\u97e9\u56fd\u4eba\u53e3\u7684\u533b\u7597\u4fdd\u9669\uff09\u3002\u533b\u9662\u9a8c\u8bc1\u961f\u5217\u5305\u62ec 1560 \u4f8b ETV \u6cbb\u7597\u60a3\u8005\u548c 1141 \u4f8b TDF \u6cbb\u7597\u60a3\u8005\uff0c\u6765\u81ea\u4e00\u5bb6\u4e09\u7ea7\u533b\u9662\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8ba1\u7b97 HCC \u7d2f\u79ef\u53d1\u75c5\u7387\u3001\u7d2f\u79ef\u6b7b\u4ea1\u7387\u548c\u7d2f\u79ef\u809d\u79fb\u690d\u7387\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5386\u53f2\u961f\u5217\u5e73\u5747\u5e74\u9f84\u4e3a 48.9 \u5c81\uff0c62.6% \u4e3a\u7537\u6027\u3002\u968f\u8bbf\u671f\u95f4\uff0c\u5171\u6709 984 \u540d\u60a3\u8005\u53d1\u751f HCC\uff0c\u5e74\u53d1\u751f\u7387\u4e3a 0.84\/\u767e\u4eba\u5e74\uff0c590 \u4f8b\u6765\u81ea ETV \u7ec4\uff0c394 \u4f8b\u6765\u81ea TDF \u7ec4\uff1b509 \u4f8b\u60a3\u8005\u6b7b\u4ea1\u6216\u63a5\u53d7\u809d\u79fb\u690d\uff0c\u5e74\u53d1\u751f\u7387\u4e3a 0.43\/\u767e\u4eba\u5e74\uff0c281 \u4f8b\u6765\u81ea ETV \u7ec4\uff0c228 \u4f8b\u6765\u81ea TDF \u7ec4\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">TDF \u7ec4\u7684 HCC \u5e74\u53d1\u751f\u7387\uff080.64\/\u767e\u4eba\u5e74\uff09\u660e\u663e\u4f4e\u4e8e ETV \u7ec4\uff081.06\/100 \u767e\u4eba\u5e74\uff09\u3002\u591a\u56e0\u7d20\u6821\u6b63\u5206\u6790\u663e\u793a\uff0cTDF \u6cbb\u7597\u7684 HCC \u98ce\u9669\uff08HR\uff1a0.61\uff1bP\uff1c0.001\uff09\u663e\u8457\u4f4e\u4e8e ETV \u6cbb\u7597\u3002\u5728\u5305\u62ec 10923 \u5bf9\u60a3\u8005\u7684\u503e\u5411\u8bc4\u5206\u5339\u914d\u5206\u6790\u4e2d\uff0c\u4e24\u4e2a\u6cbb\u7597\u7ec4\u7684 HCC \u98ce\u9669\u66f2\u7ebf\u5728\u968f\u8bbf 2 \u5e74\u540e\u5f00\u59cb\u51fa\u73b0\u5206\u79bb\uff0cTDF \u7ec4\u663e\u8457\u66f4\u4f4e\uff08HR \u4e3a 0.62\uff0cP\uff1c0.001\uff09\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5168\u56e0\u6b7b\u4ea1\u7387\u6216\u809d\u79fb\u690d\u7387\u5728 TDF \u7ec4\u4e5f\u663e\u8457\u4f4e\u4e8e ETV \u7ec4\uff0c0.36\/\u767e\u4eba\u5e74 vs.0.50\/\u767e\u4eba\u5e74\uff0c\u591a\u56e0\u7d20\u5206\u6790 HR \u4e3a 0.77\uff0cP = 0.004\u3002\u503e\u5411\u8bc4\u5206\u5339\u914d\u5206\u6790 HR \u4e3a 0.79\uff0cP = 0.01\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u533b\u9662\u9a8c\u8bc1\u961f\u5217\u5e73\u5747\u5e74\u9f84 48.8 \u5c81\uff0c61.3% \u4e3a\u7537\u6027\u3002\u968f\u8bbf 8267 \u60a3\u8005\u5e74\uff0c154 \u4f8b\u60a3\u8005\u53d1\u751f HCC\uff0c\u6bd4\u4f8b\u4e3a 5.7%\uff0c91 \u4f8b\uff083.4%\uff09\u60a3\u8005\u6b7b\u4ea1\u6216\u63a5\u53d7\u4e86\u809d\u79fb\u690d\u3002\u7ed3\u679c\u4e0e\u5386\u53f2\u961f\u5217\u76f8\u4f3c\u3002TDF \u6cbb\u7597\u4e0e HCC \u98ce\u9669\u4e0b\u964d\u72ec\u7acb\u76f8\u5173\uff0c\u591a\u56e0\u7d20\u5206\u6790 HR \u4e3a 0.66\uff08P = 0.03\uff09\u3002\u503e\u5411\u8bc4\u5206\u5339\u914d\u5206\u6790\u6821\u6b63\u4e24\u7ec4\u75c5\u6bd2\u5b66\u5e94\u7b54\u5dee\u5f02\u540e\uff0c\u4ecd\u663e\u793a TDF \u7ec4\u7684 HCC \u98ce\u9669\u663e\u8457\u4e0b\u964d\uff08HR \u4e3a 0.68\uff0cP = 0.04\uff09\u3002\u4e0d\u8fc7\u4e24\u7ec4\u7684\u6b7b\u4ea1\u6216\u809d\u79fb\u690d\u98ce\u9669\u5e76\u672a\u89c1\u663e\u8457\u5dee\u5f02\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" >\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2020\/04\/7-1587377586.jpg\" alt=\"\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff1a\u65b0\u7248\u6b27\u6d32\/\u7f8e\u56fd\u6162\u4e59\u809d\u6307\u5357\u63a8\u8350\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\" title=\"\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff1a\u65b0\u7248\u6b27\u6d32\/\u7f8e\u56fd\u6162\u4e59\u809d\u6307\u5357\u63a8\u8350\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\"  \/><\/section>\n<\/section>\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 1px;padding-right: 20px;padding-left: 20px;box-sizing: border-box;\" >\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7814\u7a76\u7ed3\u8bba<\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u57fa\u4e8e\u7fa4\u4f53\u7684\u6210\u4eba CHB \u961f\u5217\u4e2d\uff0cTDF \u6cbb\u7597\u4e0e ETV \u6cbb\u7597\u76f8\u6bd4\uff0c\u809d\u764c\u98ce\u9669\u7684\u964d\u4f4e\u66f4\u4e3a\u663e\u8457\uff1b\u8fd9\u4e00\u7ed3\u8bba\u5728\u533b\u9662\u961f\u5217\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u9274\u4e8e HCC \u60a3\u8005\u7684\u9884\u540e\u5f88\u5dee\uff0c\u5bf9\u4e8e\u6162\u6027\u4e59\u809d\u60a3\u8005\u7684\u809d\u764c\u9884\u9632\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u6216\u8bb8\u6709\u91cd\u8981\u7684\u4e34\u5e8a\u542f\u793a\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;text-align: center;box-sizing: border-box;\" >\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"border-top: 2px dotted rgb(95, 94, 102);width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(0, 193, 218);color: rgb(255, 255, 255);padding-left: 5px;padding-right: 5px;margin-top: 4px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u8c22\u5c27\u6559\u6388\u89e3\u8bfb<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 1px;padding-right: 20px;padding-left: 20px;box-sizing: border-box;\" >\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd9\u662f\u4e00\u9879\u5f88\u6709\u8da3\uff0c\u4e5f\u662f\u7ed9\u4e34\u5e8a\u533b\u751f\u5f88\u597d\u542f\u53d1\u7684\u4e00\u9879\u7814\u7a76\uff0c\u503c\u5f97\u6df1\u601d\u3002<br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u7b2c\u4e00\u601d\uff1a<\/span><\/strong>\u8fd9\u662f\u4e00\u4e2a\u6837\u672c\u91cf\u5f88\u5927\u7684\u7814\u7a76\uff0c\u4e0d\u662f\u4e00\u4e24\u4e2a\u533b\u751f\u6216\u8005\u4e00\u4e24\u4e2a\u4e2d\u5fc3\u5355\u6253\u72ec\u6597\u5c31\u53ef\u4ee5\u5b8c\u6210\u7684\u3002\u8fd9\u63d0\u793a\u6211\u4eec\u534f\u4f5c\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u7b2c\u4e8c\u601d\uff1a<\/span><\/strong>\u6297\u75c5\u6bd2\u6cbb\u7597\u662f\u963b\u65ad\u548c\u5ef6\u7f13\u6162\u6027\u809d\u810f\u75be\u75c5\u8fdb\u5c55\u7684\u91cd\u8981\u624b\u6bb5\uff0c\u867d\u7136\u6297\u75c5\u6bd2\u6cbb\u7597\u7684\u76ee\u7684\u662f\u964d\u4f4e\u809d\u786c\u5316\u3001\u809d\u529f\u80fd\u8870\u7aed\u548c\u809d\u7ec6\u80de\u764c\u7684\u53d1\u751f\u7387\uff0c\u4f46\u7531\u4e8e\u4e34\u5e8a\u7ec8\u70b9\u4e8b\u4ef6\u9700\u8981\u5bf9\u60a3\u8005\u8fdb\u884c\u957f\u671f\u7684\u6cbb\u7597\u548c\u89c2\u5bdf\uff0c\u6297\u75c5\u6bd2\u7597\u6548\u7684\u8bc4\u4ef7\u66f4\u591a\u4ee5\u6cbb\u7597\u8fd1\u671f\u7684\u75c5\u6bd2\u5b66\u6307\u6807\u548c\u809d\u529f\u80fd\u7b49\u751f\u5316\u6307\u6807\u5e94\u7b54\u6240\u66ff\u4ee3\uff0c\u5982 HBV DNA \u662f\u5426\u8f6c\u9634\u3001\u8f6c\u6c28\u9176\u662f\u5426\u6062\u590d\u6b63\u5e38\uff0c\u809d\u529f\u80fd\u6709\u65e0\u6539\u5584\u7b49\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7531\u4e8e\u60a3\u8005\u5728\u83b7\u5f97\u75c5\u6bd2\u5b66\u5e94\u7b54\u65f6\u5e38\u5e38\u80fd\u83b7\u5f97\u809d\u529f\u80fd\u7684\u6539\u5584\uff0c\u8fd9\u4e9b\u7ec8\u70b9\u5728\u4e34\u5e8a\u6cbb\u7597\u4e2d\u4e5f\u8f83\u4e3a\u5bb9\u6613\u8fbe\u5230\uff0c\u56e0\u6b64\uff0c\u5728\u6297\u75c5\u6bd2\u6cbb\u7597\u57fa\u7840\u4e0a\uff0cHCC \u53ef\u80fd\u662f\u6700\u91cd\u8981\u7684\u4e34\u5e8a\u7ec8\u70b9\u4e8b\u4ef6\u3002\u4f46\u540c\u65f6\u7531\u4e8e\u809d\u7ec6\u80de\u764c\u7684\u53d1\u751f\u7387\u4f4e\u3001\u9700\u8981\u89c2\u5bdf\u7684\u65f6\u95f4\u957f\uff0c\u8fd9\u4e2a\u6307\u6807\u4e0a\u7684\u53d8\u5316\u5f88\u96be\u89c2\u5bdf\u3002\u8fd9\u9879\u5927\u6837\u672c\u91cf\u7684\u7814\u7a76\u7ed3\u679c\u5f88\u6709\u53c2\u8003\u610f\u4e49\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u7b2c\u4e09\u601d\uff1a<\/span><\/strong>\u5728\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u6297\u75c5\u6bd2\u6cbb\u7597\u4e2d\uff0cETV \u548c TDF \u5177\u6709\u76f8\u4f3c\u7684\u6cbb\u7597\u5e94\u7b54\u7387\u548c\u9ad8\u8010\u836f\u5c4f\u969c\uff0c\u4e24\u8005\u5747\u5217\u4e3a\u4e00\u7ebf\u6cbb\u7597<span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u7269&nbsp;<\/span><sup style=\"max-width: 100%;letter-spacing: 1px;white-space: normal;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[2\uff5e4]<\/sup>\uff0c\u4f46\u76ee\u524d\u5c1a\u7f3a\u4e4f\u6bd4\u8f83\u4e24\u8005\u964d\u4f4e HCC \u53d1\u751f\u4f5c\u7528\u7684\u5927\u6837\u672c\u961f\u5217\u7814\u7a76\u3002\u672c\u7814\u7a76\u901a\u8fc7\u97e9\u56fd\u5168\u56fd\u8303\u56f4\u4eba\u7fa4\u548c\u533b\u9662\u4eba\u7fa4\u5927\u6837\u672c\u7684\u89c2\u5bdf\u961f\u5217\u7814\u7a76\uff0c\u53d1\u73b0 TDF \u4e0e ETV \u76f8\u6bd4\u8f83\uff0c\u66f4\u80fd\u663e\u8457\u964d\u4f4e HCC \u53d1\u751f\u7684\u5371\u9669\u6027\uff0c\u4e14 TDF \u6bd4 ETV \u6709\u66f4\u9ad8\u7684\u75c5\u6bd2\u5b66\u5e94\u7b54\u7387\u3002\u7814\u7a76\u8005\u8fdb\u884c\u4e86\u5404\u79cd\u5339\u914d\uff0c\u5c3d\u91cf\u6392\u9664\u4e86\u57fa\u7ebf\u56e0\u7d20\u7684\u5e72\u6270\uff0c\u5982\u809d\u786c\u5316\u7a0b\u5ea6\u3001\u5e74\u9f84\u4ee5\u53ca\u5bb6\u65cf\u53f2\u7b49\uff0c\u4ecd\u7136\u5f97\u51fa TDF \u964d\u4f4e HCC \u98ce\u9669\u7684\u4f5c\u7528\u4f18\u4e8e ETV\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u75c5\u6bd2\u5b66\u5e94\u7b54\u867d\u7136\u4e0e HCC \u98ce\u9669\u964d\u4f4e\u6709\u5173\uff0c\u4f46\u5e76\u975e HCC \u98ce\u9669\u7684\u72ec\u7acb\u9884\u6d4b\u56e0\u7d20\u3002\u4e8c\u8005\u7684\u5dee\u5f02\u6216\u8bb8\u4e0d\u80fd\u7528\u6297\u75c5\u6bd2\u7597\u6548\u7684\u5dee\u5f02\u6765\u89e3\u91ca\u3002\u8fd9\u63d0\u793a\u9664\u75c5\u6bd2\u5b66\u5e94\u7b54\u5916\uff0c\u66ff\u8bfa\u798f\u97e6\u916f\u964d\u4f4e HCC \u53d1\u751f\u98ce\u9669\u53ef\u80fd\u5b58\u5728\u5176\u4ed6\u673a\u5236\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u7b2c\u56db\u601d\uff1a<\/span><\/strong>\u4e0d\u540c\u56fd\u5bb6\u548c\u5730\u533a\u4eba\u7fa4\u7684\u9057\u4f20\u80cc\u666f\u4e0d\u540c\u3002\u4e2d\u56fd\u3001\u97e9\u56fd\u7b49\u4e9a\u6d32\u56fd\u5bb6\u7684\u809d\u764c\u53d1\u751f\u7387\u660e\u663e\u9ad8\u4e8e\u6b27\u7f8e\u3002\u5176\u539f\u56e0\u4e4b\u4e00\u4e0e\u4e0d\u540c\u5730\u533a\u4e3b\u8981\u6d41\u884c\u7684 HBV \u57fa\u56e0\u578b\u6709\u5173\uff0c\u6211\u56fd\u4ee5 B\u3001C \u578b\u4e3a\u4e3b\uff0c\u6b27\u7f8e\u5219\u4ee5 A\u3001D \u578b\u4e3a\u4e3b\uff0cB\u3001C \u578b HBV \u611f\u67d3\u65f6\u7684\u809d\u764c\u98ce\u9669\u66f4\u9ad8\u3002\u56e0\u6b64\uff0c\u540c\u6837\u7684\u6bd4\u8f83\u7814\u7a76\uff0c\u5728\u6b27\u7f8e\u4eba\u7fa4\u4e2d\u53ef\u80fd\u770b\u4e0d\u5230\u5dee\u5f02\uff0c\u4f46\u5728\u6211\u56fd\uff0c\u5c31\u53ef\u80fd\u5b58\u5728\u533a\u522b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u7b2c\u4e94\u601d\uff1a<\/span><\/strong>TDF \u4e0e ETV \u964d\u4f4e HCC \u98ce\u9669\u7684\u5dee\u5f02\uff0c\u8fd9\u4e2a\u7ed3\u679c\u6765\u81ea\u7fa4\u4f53\u7814\u7a76\uff0c\u5728\u4eba\u7fa4\u7fa4\u4f53\u6216\u662f\u4e00\u4e2a\u7701\u3001\u4e00\u4e2a\u56fd\u5bb6\u5c42\u9762\uff0c\u5f88\u6709\u501f\u9274\u610f\u4e49\uff0c\u4f46\u5bf9\u4e8e\u5355\u72ec\u7684\u60a3\u8005\u4e2a\u4f53\u5219\u4e0d\u80fd\u6982\u800c\u8bba\u4e4b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u7b2c\u516d\u601d\uff1a<\/span><\/strong>\u8fd9\u9879\u7814\u7a76\u4e3b\u8981\u89c2\u5bdf\u7684\u662f\u4e24\u79cd\u836f\u7269\u957f\u671f\u6cbb\u7597\u540e\u7684 HCC \u53d1\u751f\u7387\u5dee\u5f02\uff0c\u5e76\u6ca1\u6709\u6d89\u53ca\u5176\u4ed6\u6bd4\u8f83\u3002\u4f46 TDF \u5b58\u5728\u80be\u529f\u80fd\u635f\u4f24\u548c\u5f71\u54cd\u9aa8\u5bc6\u5ea6\u7684\u526f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5982\u679c\u60a3\u8005\u672c\u6765\u5c31\u5b58\u5728\u9aa8\u8d28\u758f\u677e\u6216\u8005\u6709\u80be\u529f\u80fd\u635f\u4f24\uff0c\u4f8b\u5982\u5408\u5e76\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u7684\u60a3\u8005\uff0c\u5728\u6cbb\u7597\u4e2d\u5c31\u53ef\u80fd\u4f1a\u66f4\u591a\u8003\u8651\u80be\u810f\u548c\u9aa8\u9abc\u7684\u5b89\u5168\u6027\u95ee\u9898\uff0c\u6bd5\u7adf\u80bf\u7624\u7684\u53d1\u751f\u5f71\u54cd\u56e0\u7d20\u5f88\u591a\uff0c\u800c\u4e14\u662f\u4e00\u4e2a\u4f4e\u6982\u7387\u4e8b\u4ef6\u3002\u53ef\u89c1\uff0c\u5c3d\u7ba1\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u4ece\u964d\u4f4e HCC \u53d1\u751f\u98ce\u9669\u89d2\u5ea6\u8003\u8651\uff0cTDF \u8f83 ETV \u53ef\u80fd\u66f4\u6709\u4f18\u52bf\uff0c\u4f46\u4e34\u5e8a\u533b\u751f\u5728\u4e3a\u60a3\u8005\u5236\u8ba2\u6cbb\u7597\u65b9\u6848\u65f6\uff0c\u8fd8\u662f\u5e94\u5f53\u6839\u636e\u6574\u4f53\u60c5\u51b5\u8003\u8651\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;text-align: center;box-sizing: border-box;\" >\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"border-top: 2px dotted rgb(95, 94, 102);width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"background-color: rgb(0, 193, 218);color: rgb(255, 255, 255);padding-left: 5px;padding-right: 5px;margin-top: 4px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u7ed3\u8bed<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 1px;padding-right: 20px;padding-left: 20px;box-sizing: border-box;\" >\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u97e9\u56fd\u5b66\u8005\u7684\u8fd9\u9879\u7814\u7a76\u662f\u76ee\u524d\u9996\u4e2a\u53cd\u6620 TDF \u6709\u66f4\u5f3a\u9884\u9632 HCC \u4f5c\u7528\u7684\u7814\u7a76\u3002\u5728\u6587\u7ae0\u7684\u8ba8\u8bba\u90e8\u5206\uff0c\u4f5c\u8005\u5bf9 TDF \u964d\u4f4e HCC \u98ce\u9669\u7684\u53ef\u80fd\u673a\u5236\u63d0\u51fa\u4e86\u4e24\u4e2a\u89e3\u91ca\uff0c\u4e0d\u8fc7\u90fd\u8fd8\u9650\u4e8e\u52a8\u7269\u7814\u7a76\u3002\u5982\u6709\u7814\u7a76\u53d1\u73b0\u6838\u82f7\u9178\u7c7b\u836f\u7269\uff08\u5982\u66ff\u8bfa\u798f\u97e6\uff09\u548c\u6838\u82f7\u7c7b\u836f\u7269\uff08\u5982\u6069\u66ff\u5361\u97e6\uff09\u5bf9\u5e72\u6270\u7d20\u03bb\u7684\u5f71\u54cd<span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0d\u540c&nbsp;<\/span><sup style=\"max-width: 100%;letter-spacing: 1px;white-space: normal;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[5]<\/sup><span style=\"font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);\">\uff0c\u800c\u5e72\u6270\u7d20\u03bb\u6709\u5f88\u5f3a\u7684\u6297\u80bf\u7624<\/span><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6d3b\u6027&nbsp;<\/span><sup style=\"max-width: 100%;letter-spacing: 1px;white-space: normal;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[6,7]<\/sup><span style=\"font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);\">\u3002\u53e6\u5916\u6709\u52a8\u7269\u5b9e\u9a8c\u663e\u793a\u6069\u66ff\u5361\u97e6\u5728\u5927\u5242\u91cf\u5e94\u7528\u65f6\u53ef\u80fd\u8bf1\u53d1\u556e\u9f7f\u7c7b\u52a8\u7269<\/span><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u80bf\u7624&nbsp;<\/span><sup style=\"max-width: 100%;letter-spacing: 1px;white-space: normal;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[8]<\/sup><span style=\"font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);\">\u3002<\/span>\u4f46\u4ee5\u4e0a\u673a\u5236\u662f\u5426\u5bfc\u81f4\u4e86\u4e24\u79cd\u836f\u7269\u964d\u4f4e HCC \u98ce\u9669\u7684\u5dee\u5f02\uff0c\u8fd8\u53ea\u662f\u5047\u8bf4\uff0c\u9700\u8981\u5927\u91cf\u7814\u7a76\u8fdb\u4e00\u6b65\u6838\u5b9e\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e0e\u97e9\u56fd\u5b66\u8005\u8fd9\u7bc7\u6587\u7ae0\u540c\u671f\u53d1\u5e03\u7684\u8fd8\u6709\u4e00\u7bc7\u7531\u52a0\u62ff\u5927\u7687\u540e\u5927\u5b66 Jennifer A. Flemming \u535a\u58eb\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66 Norah A. Terrault \u535a\u58eb\u5171\u540c\u7f72\u540d\u7684\u8bc4\u8bba<span style=\"max-width: 100%;font-size: 14px;letter-spacing: 1px;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6587\u7ae0<\/span><sup style=\"max-width: 100%;letter-spacing: 1px;white-space: normal;background-color: rgb(255, 255, 255);font-family: Avenir, &quot;Hiragino Sans GB&quot;, &quot;Noto Sans S Chinese&quot;, &quot;Microsoft Yahei&quot;, &quot;Microsoft Sans Serif&quot;, &quot;WenQuanYi Micro Hei&quot;, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;[9]<\/sup>\uff08Tenofovir vs Entecavir for Hepatocellular Carcinoma Prevention in Patients With Chronic Hepatitis B &#8211; One of These Things Is Not Like the Other\uff09\u3002\u6587\u7ae0\u4e2d\u6307\u51fa\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u9664\u4e86\u5728\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\u4eba\u7fa4\u4e2d\u4ee5\u5916\uff0c\u5e76\u6ca1\u6709\u5176\u4ed6\u76f4\u63a5\u7684\u5934\u5bf9\u5934\u968f\u673a\u5316\u8bd5\u9a8c\u6765\u6bd4\u8f83 ETV \u548c TDF\u3002\u5728\u7279\u5b9a\u4e34\u5e8a\u60c5\u51b5\u4e0b\u6216\u4e9a\u7ec4\u4eba\u7fa4\u4e2d\uff0c\u4e00\u79cd\u836f\u662f\u5426\u4f18\u4e8e\u53e6\u5916\u4e00\u79cd\u836f\uff1f<span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u300c\u5728\u7f3a\u5c11\u968f\u673a\u5316\u6bd4\u8f83\u7814\u7a76\u7684\u60c5\u51b5\u4e0b\uff0c\u9ad8\u8d28\u91cf\u7684\u771f\u5b9e\u4e16\u754c\u961f\u5217\u53ef\u63d0\u4f9b\u5927\u91cf\u4fe1\u606f\u300d<\/span>\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cTDF \u6cbb\u7597\u4eba\u7fa4\u7684 HCC \u98ce\u9669\u6bd4 ETV \u6cbb\u7597\u4eba\u7fa4\u4f4e\u5927\u7ea6 35%\uff0c\u5728\u6309\u809d\u786c\u5316\u72b6\u51b5\u5206\u5c42\u4ee5\u53ca\u5bf9\u5176\u4ed6\u591a\u79cd\u6df7\u6742\u56e0\u5b50\u6821\u6b63\u540e\uff0c\u8fd9\u4e00\u5173\u7cfb\u4ecd\u7136\u5b58\u5728\u3002\u6309\u7167\u97e9\u56fd\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u82e5\u8981\u6709\u8db3\u591f\u7684\u7edf\u8ba1\u5b66\u6548\u529b\u68c0\u6d4b\u51fa HCC \u98ce\u9669\u964d\u4f4e 35%\uff0cHCC \u4f8b\u6570\u81f3\u5c11\u8981\u8fbe\u5230 200 \u4f8b\uff0c\u800c\u8fc7\u53bb\u8bb8\u591a\u7814\u7a76\u8fbe\u4e0d\u5230\u8fd9\u4e2a\u6807\u51c6\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e0d\u8fc7\uff0c\u7531\u4e8e\u89c2\u5bdf\u6027\u7814\u7a76\u56fa\u6709\u7684\u5c40\u9650\uff0c\u4ee5\u53ca\u8fd8\u6709\u5927\u91cf\u95ee\u9898\u6ca1\u6709\u89e3\u51b3\uff0c\u5982\u6ca1\u6709\u8003\u8651\u6297\u75c5\u6bd2\u6cbb\u7597\u7684\u4f9d\u4ece\u6027\uff0c\u4ee5\u53ca\u91c7\u7528\u7684 HCC \u76d1\u6d4b\u65b9\u6cd5\uff0c\u4ee5\u53ca\u5728\u66fe\u7ecf\u6709\u62c9\u7c73\u592b\u5b9a\u5927\u91cf\u5e94\u7528\u7684\u5730\u533a\uff0cETV \u957f\u671f\u6cbb\u7597\u65f6\u7684\u75c5\u6bd2\u5b66\u7a81\u7834\u98ce\u9669\u53ef\u80fd\u589e\u52a0\uff0c\u8fd9\u540c\u6837\u4f1a\u589e\u52a0 HCC \u7684\u98ce\u9669\u7b49\uff0c\u8bc4\u8bba\u6587\u7ae0\u4f5c\u8005\u8ba4\u4e3a\uff0c\u5f53\u524d\u8fd8\u4e0d\u5e94\u8be5\u5e7f\u6cdb\u66f4\u6539\u6cbb\u7597\u65b9\u6848\u3002\u4ed6\u4eec\u5e0c\u671b\u66f4\u591a\u7684\u7814\u7a76\u8005\u6765\u63a2\u7d22 ETV \u548c TDF \u7684\u5b70\u4f18\u5b70\u52a3\uff0c<span style=\"color: rgb(250, 0, 0);box-sizing: border-box;\">\u300c\u4e09\u79cd\u5b89\u5168\u6709\u6548\u7684\u53e3\u670d\u6297\u75c5\u6bd2\u836f\u7269\u5f97\u5230\u4e13\u5bb6\u652f\u6301\uff0c\u4f5c\u4e3a\u6162\u4e59\u809d\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u5b83\u4eec\u662f ETV\u3001TDF \u548c\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff08TAF\uff09\uff0c\u8fd9\u4e9b\u836f\u7269\u90fd\u6709\u5f88\u5f3a\u7684\u964d\u4f4e HBV DNA \u6c34\u5e73\u7684\u4f5c\u7528\u4ee5\u53ca\u975e\u5e38\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u3002\u5728\u4e3a\u6bcf\u4e00\u4f8b\u60a3\u8005\u5236\u8ba2\u6700\u4f73\u6cbb\u7597\u7b56\u7565\u65f6\uff0c\u533b\u751f\u5e94\u8003\u8651\u60a3\u8005\u7684\u6cbb\u7597\u53f2\u3001\u5171\u60a3\u75be\u75c5\uff08\u5305\u62ec\u80be\u75c5\u6216 HIV \u611f\u67d3\uff09\u3001\u836f\u7269\u6210\u672c\u548c\u53ef\u53ca\u6027\u3002\u9884\u9632\u809d\u810f\u76f8\u5173\u7684\u5e76\u53d1\u75c7\u9700\u8981\u4f9d\u4ece\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u4e14\u53d6\u5f97\u75c5\u6bd2\u6291\u5236\u300d<\/span>\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"text-align: center;box-sizing: border-box;\" >\n<section style=\"display: inline-block;width: 100%;height: 240px;vertical-align: top;overflow-y: auto;box-sizing: border-box;-webkit-overflow-scrolling: touch;\">\n<section style=\"overflow-x: hidden;box-sizing: border-box;\">\n<section style=\"margin-top: 20px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" >\n<section style=\"display: inline-block;border-width: 2px;border-style: solid;border-color: rgb(251, 250, 245);padding: 0.1em 0.3em;color: rgb(62, 62, 62);text-align: justify;font-size: 12px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">1.Choi J, Kim HJ, Lee J, et al. Risk of hepatocellular carcinoma in patients treated with entecavir vs tenofovir for chronic hepatitis B: a Korean nationwide cohort study [published online September 27, 2018]. JAMA Oncol. doi:10.1001\/jamaoncol.2018.4070<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">2.Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-1599. doi:10.1002\/hep.29800<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">3.European Association for the Study of the Liver. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol. 2012; 57(1):167-185. doi:10.1016\/j.jhep.2012.02.010<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">4. \u4e2d\u534e\u533b\u5b66\u4f1a\u809d\u75c5\u5b66\u5206\u4f1a\uff0c\u4e2d\u534e\u533b\u5b66\u4f1a\u611f\u67d3\u75c5\u5b66\u5206\u4f1a\uff0e\u6162\u6027\u4e59\u578b\u809d\u708e\u9632\u6cbb\u6307\u5357 ( 2015 \u5e74\u66f4\u65b0\u7248). \u4e34\u5e8a\u809d\u80c6\u75c5\u6742\u5fd7. 2015;31(12): 1941-1960.<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">5.Murata K, Asano M, Matsumoto A, et al. Induction of IFN-\u03bb3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection. Murata K, et al. Gut 2016;0:1-10. doi:10.1136\/gutjnl-2016-312653<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">6.AbushahbaW, Balan M, Castaneda I, et al. Antitumor activity of type I and type III interferons in BNL hepatoma model. Cancer Immunol Immunother. 2010;59(7):1059-1071. doi:10.1007 \/s00262-010-0831-3<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">7.Sato A, Ohtsuki M, Hata M, Kobayashi E, Murakami T. Antitumor activity of IFN-lambda in murine tumor models. J Immunol. 2006;176(12): 7686-7694. doi:10.4049\/jimmunol.176.12.7686<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">8.US Food and Drug Administration. NDA Review pharmacology\/toxicology review and evaluation: NDA No. 21-797: submitted September 30, 2004. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs \/nda\/2005\/21797_BARACLUDE_pharmr.PDF.&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: left;\">9.Flemming JA, Terrault NA. Tenofovir vs Entecavir for Hepatocellular Carcinoma Prevention in PatientsWith Chronic Hepatitis B One of These Things Is Not Like the Other. [published online September 27, 2018]. JAMA Oncol. doi:10.1001\/jamaoncol.2018.4039<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2018 \u5e74 9 \u6708\uff0cJAMA Oncology \u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u97e9\u56fd\u7684\u4e00\u9879\u7814\u7a76&nbsp;[1]\uff0c\u6587\u7ae0\u4e00\u7ecf [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":119964,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/119963"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=119963"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/119963\/revisions"}],"predecessor-version":[{"id":119967,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/119963\/revisions\/119967"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/119964"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=119963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=119963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=119963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}