{"id":121061,"date":"2019-11-14T23:18:27","date_gmt":"2020-04-21T00:48:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/121061\/"},"modified":"2020-04-21T08:48:28","modified_gmt":"2020-04-21T00:48:28","slug":"07809331c5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/121061\/","title":{"rendered":"\u91cd\u5927\u7a81\u7834\uff01\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u65b0\u836f\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff01\u606d\u559c\u767e\u6d4e\u795e\u5dde\uff01"},"content":{"rendered":"
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\n
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\u5728118\u4f4d\u63a5\u53d7BRUKINSA\u6cbb\u7597\u7684MCL\u60a3\u8005\u4e2d\uff0c\u516b\u4f4d\u60a3\u8005\uff087%\uff09\u7531\u4e8e\u4e0d\u826f\u53cd\u5e94\u4e2d\u65ad\u6cbb\u7597\u3002<\/span>\u5bfc\u81f4\u6cbb\u7597\u4e2d\u65ad\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u80ba\u708e\uff083.4%\uff09\u3002<\/span>\u4e00\u4f4d\u60a3\u8005\uff080.8%\uff09\u7531\u4e8e\u4e0d\u826f\u53cd\u5e94\u800c\u51cf\u5c11\u836f\u7269\u5242\u91cf\uff08\u4e59\u809d\uff09\u3002<\/span><\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n

\n
BRUKINSA\u7684\u63a8\u8350\u7528\u836f\u5242\u91cf\u4e3a320mg\u2014\u2014\u6bcf\u6b21160mg\u3001\u6bcf\u65e5\u4e24\u6b21\u53e3\u670d\u7528\u836f\u6216\u662f\u6bcf\u6b21320mg\u3001\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7528\u836f\uff0c\u7a7a\u8179\u6216\u8fdb\u98df\u65f6\u670d\u7528\u5747\u53ef\u3002<\/span>\u836f\u7269\u5242\u91cf\u53ef\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u8fdb\u884c\u9002\u5f53\u8c03\u6574\uff0c\u4ee5\u53ca\u5728\u4e25\u91cd\u809d\u635f\u5bb3\u60a3\u8005\u4e2d\u4ee5\u53ca\u7279\u5b9a\u836f\u7269\u53cd\u5e94\u4e2d\u51cf\u5c11\u5242\u91cf [i]\u3002<\/span><\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n

\n
BRUKINSA\u9884\u8ba1\u5728\u672a\u6765\u51e0\u5468\u5185\u5728\u7f8e\u56fd\u8fdb\u884c\u9500\u552e\u3002<\/span><\/section>\n<\/section>\n
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<\/p>\n<\/section>\n

\n
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\u5173\u4e8e\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09<\/strong><\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n
\u6dcb\u5df4\u7624\u662f\u4e00\u7ec4\u8d77\u6e90\u4e8eB\u3001T\u6216NK\u7ec6\u80de\u7684\u542b\u591a\u79cd\u4e9a\u578b\u7684\u6076\u6027\u80bf\u7624\u3002<\/span>\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u901a\u5e38\u662f\u4fb5\u88ad\u6027\u7684\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\uff0c\u8d77\u6e90\u4e8e\u201c\u5957\u533a\u201d\u7684B\u7ec6\u80de [ii]\u3002<\/span>2019\u5e74\uff0c\u5728\u7f8e\u56fd\u9884\u8ba1\u7ea6\u670974,200\u65b0\u589eNHL\u75c5\u4f8b [iii]\uff0c\u5176\u4e2dMCL\u65b0\u589e\u75c5\u4f8b\u4e3a\u603b\u6570\u76846%\uff08\u7ea64,452\u8d77\uff09 [ii]\u3002<\/span>\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u901a\u5e38\u9884\u540e\u5f88\u5dee\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a\u4e09\u81f3\u56db\u5e74 [iv]\u3002<\/span>\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u5728\u8bca\u65ad\u65f6\u901a\u5e38\u5df2\u7ecf\u5904\u4e8e\u75be\u75c5\u665a\u671f\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u5173\u4e8eBRUKINSA\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09<\/strong><\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n
BRUKINSA\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u5f00\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002<\/span>BRUKINSA\u4e8e11\u670814\u65e5\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u9879\u7597\u6cd5\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\u3002<\/span><\/section>\n


<\/p>\n

BRUKINSA\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09MCL\u60a3\u8005\u548cR\/R\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005\u7684\u4e24\u9879\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5df2\u88ab\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u6b63\u5728\u5ba1\u6279\u8fc7\u7a0b\u4e2d\u3002<\/span><\/section>\n


<\/p>\n

BRUKINSA\u5728\u7f8e\u56fd\u4ee5\u5916\u56fd\u5bb6\u5730\u533a\u5c1a\u672a\u83b7\u6279\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
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\n

\u5173\u4e8e\u6cfd\u5e03\u66ff\u5c3c\u7684\u4e34\u5e8a\u9879\u76ee<\/strong><\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n
\u6cfd\u5e03\u66ff\u5c3c\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u5305\u62ec:<\/span><\/section>\n


<\/p>\n

    \n
  • \n
    \u6cfd\u5e03\u66ff\u5c3c\u5bf9\u6bd4\u4f0a\u5e03\u66ff\u5c3c\uff08\u552f\u4e00\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u8be5\u9002\u5e94\u75c7\u7684BTK\u6291\u5236\u5242\uff09\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u7684ASPEN 3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03053440\uff1b<\/span>\u76ee\u524d\u5df2\u5b8c\u6210\u60a3\u8005\u5165\u7ec4\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


    <\/p>\n

      \n
    • \n
      \u6cfd\u5e03\u66ff\u5c3c\u5bf9\u6bd4\u82ef\u8fbe\u83ab\u53f8\u6c40\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u521d\u6cbb\uff08TN\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005\u7684SEQUOIA 3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03336333\uff09<\/span><\/section>\n<\/li>\n<\/ul>\n


      <\/p>\n

        \n
      • \n
        \u6cfd\u5e03\u66ff\u5c3c\u5bf9\u6bd4\u4f0a\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09CLL\u6216SLL\u60a3\u8005\u7684ALPINE 3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03734016\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


        <\/p>\n

          \n
        • \n
          \u6cfd\u5e03\u66ff\u5c3c\u8054\u5408GAZYVA\u00ae\u5965\u6bd4\u59a5\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597R\/R\u6ee4\u6ce1\u578b\u6dcb\u5df4\u7624\uff08FL\uff09\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03332017\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


          <\/p>\n

            \n
          • \n
            \u6cfd\u5e03\u66ff\u5c3c\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\u5bf9\u6bd4\u82ef\u8fbe\u83ab\u53f8\u6c40\u8054\u5408\u5229\u59a5\u6614\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT04002297\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


            <\/p>\n

              \n
            • \n
              \u6cfd\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597R\/R\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005\u7684MAGNOLIA 2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03846427\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


              <\/p>\n

                \n
              • \n
                \u6cfd\u5e03\u66ff\u5c3c\u8054\u5408\u5965\u6bd4\u59a5\u73e0\u5355\u6297\u5bf9\u6bd4\u5965\u6bd4\u59a5\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597R\/R FL\u60a3\u8005\u7684ROSEWOOD 2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03332017\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


                <\/p>\n

                  \n
                • \n
                  \u6cfd\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597R\/R MCL\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03206970\uff1b<\/span>\u5df2\u5b8c\u6210\uff09\u4ee5\u53ca\u6cbb\u7597R\/R CLL\u6216SLL\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03206918\uff1b<\/span>\u5df2\u5b8c\u6210\uff09\uff1b<\/span><\/section>\n<\/li>\n<\/ul>\n


                  <\/p>\n

                    \n
                  • \n
                    \u6cfd\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597WM\u60a3\u8005\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u767b\u8bb0\u53f7\uff1a<\/span>NCT03332173\uff1b<\/span>\u5df2\u5b8c\u6210\u60a3\u8005\u5165\u7ec4\uff09\u3002<\/span><\/section>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n
                    \n
                    \n
                    \n
                    \n

                    \u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/strong><\/strong><\/span><\/p>\n<\/section>\n

                    <\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n<\/section>\n

                    \n
                    \n
                    \u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u6027\u7684\u3001\u5546\u4e1a\u9636\u6bb5\u7684\u3001\u4ee5\u7814\u53d1\u4e3a\u57fa\u7840\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5206\u5b50\u9776\u5411 \u548c\u514d\u75ab\u80bf\u7624\u7597\u6cd5\u7684\u7814\u53d1\u3002<\/span>\u767e\u6d4e\u795e\u5dde\u76ee\u524d\u5728\u4e2d\u56fd\u5927\u9646\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u745e\u58eb\u62e5\u67093,000\u591a\u540d\u5458\u5de5\uff0c\u5728\u7814\u4ea7\u54c1\u7ebf\u5305\u62ec\u65b0\u578b\u53e3\u670d\u5c0f\u5206\u5b50\u7c7b\u548c\u5355\u514b\u9686\u6297\u4f53\u7c7b\u6297\u764c\u836f\u7269\u3002<\/span>\u767e\u6d4e\u795e\u5dde\u76ee\u524d\u4e5f\u6b63\u5728\u6253\u9020\u6297\u764c\u6cbb\u7597\u7684\u836f\u7269\u7ec4\u5408\u65b9\u6848\uff0c\u65e8\u5728\u4e3a\u764c\u75c7\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u6301\u7eed\u3001\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/span>\u767e\u6d4e\u795e\u5dde\u5728\u7f8e\u56fd\u9500\u552eBRUKINSA\u2122\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\uff1b<\/span>\u5728\u65b0\u57fa\u516c\u53f8\u7684\u6388\u6743\u4e0b\uff0c\u767e\u6d4e\u795e\u5dde\u5728\u534e\u9500\u552e ABRAXANE\u00ae\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u7eb3\u7c73\u767d\u86cb\u767d\u9897\u7c92 \u7ed3\u5408\u578b\uff09\u3001\u745e\u590d\u7f8e\u00ae\uff08\u6765\u90a3\u5ea6\u80fa\uff09\u548c\u7ef4\u8fbe\u838e\u00ae\uff08\u6ce8\u5c04\u7528\u963f\u624e\u80de\u82f7\uff09[v]\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    BRUKINSA\u91cd\u8981\u5b89\u5168\u4fe1\u606f<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u8b66\u544a\u4e0e\u6ce8\u610f\u4e8b\u9879<\/span><\/strong><\/span><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u51fa\u8840<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u81f4\u6b7b\u4e0e\u4e25\u91cd\u51fa\u8840\u4e8b\u4ef6\u51fa\u73b0\u5728\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u8840\u6db2\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u3002<\/span>\u5305\u62ec\u9885\u5185\u548c\u80c3\u80a0\u9053\u51fa\u8840\u3001\u8840\u5c3f\u3001\u8840\u80f8\u5728\u5185\u7684\u4e09\u7ea7\u53ca\u4ee5\u4e0a\u51fa\u8840\u4e8b\u4ef6\u51fa\u73b0\u57282%\u7684\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002<\/span>\u5305\u62ec\u7d2b\u765c\u548c\u7600\u70b9\u5728\u5185\u7684\u4efb\u4e00\u7ea7\u522b\u7684\u51fa\u8840\u4e8b\u4ef6\u51fa\u73b0\u572850%\u7684\u63a5\u53d7\u6cfd\u5e03\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u65e0\u8bba\u60a3\u8005\u662f\u5426\u63a5\u53d7\u8fc7\u6297\u51dd\u548c\u6297\u8840\u5c0f\u677f\u7684\u8054\u5408\u6cbb\u7597\uff0c\u5747\u6709\u51fa\u8840\u4e8b\u4ef6\u53d1\u751f\u3002<\/span>BRUKINSA\u4e0e\u6297\u8840\u5c0f\u677f\u6216\u6297\u51dd\u6cbb\u7597\u8054\u7528\uff0c\u53ef\u80fd\u52a0\u5267\u51fa\u8840\u98ce\u9669\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u6ce8\u610f\u76d1\u6d4b\u51fa\u8840\u7684\u8ff9\u8c61\u548c\u75c7\u72b6\u3002<\/span>\u5982\u679c\u51fa\u73b0\u4efb\u4e00\u7ea7\u522b\u7684\u9885\u5185\u51fa\u8840\uff0c\u8bf7\u7acb\u5373\u505c\u6b62BRUKINSA\u6cbb\u7597\u3002<\/span>\u53d6\u51b3\u4e8e\u624b\u672f\u7c7b\u578b\u548c\u51fa\u8840\u98ce\u9669\uff0c\u8bf7\u6743\u8861\u6536\u76ca\u4e0e\u98ce\u9669\uff0c\u8003\u8651\u5728\u624b\u672f\u524d\u540e\u4e09\u81f3\u4e03\u5929\u6682\u505c\u4f7f\u7528\u63a5\u53d7BRUKINSA\u6cbb\u7597\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u611f\u67d3<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u81f4\u6b7b\u4e0e\u4e25\u91cd\u611f\u67d3\u4e8b\u4ef6\uff08\u5305\u62ec\u7ec6\u83cc\u3001\u75c5\u6bd2\u4ee5\u53ca\u771f\u83cc\u611f\u67d3\uff09\u4ee5\u53ca\u673a\u4f1a\u6027\u611f\u67d3\u51fa\u73b0\u5728\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u8840\u6db2\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u3002<\/span>\u4e09\u7ea7\u53ca\u4ee5\u4e0a\u611f\u67d3\u4e8b\u4ef6\u51fa\u73b0\u572823%\u7684\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002<\/span>\u6700\u5e38\u89c1\u7684\u4e09\u7ea7\u53ca\u4ee5\u4e0a\u7684\u611f\u67d3\u4e3a\u80ba\u708e\u3002<\/span>\u7531\u4e8e\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u5f15\u8d77\u7684\u611f\u67d3\u4e8b\u4ef6\u4e5f\u6709\u53d1\u751f\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u6839\u636e\u611f\u67d3\u98ce\u9669\u589e\u52a0\u4e14\u63a5\u53d7\u6807\u51c6\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u8bf7\u8003\u8651\u9884\u9632\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u3001\u80ba\u56ca\u866b\u80ba\u708e\u4ee5\u53ca\u5176\u4ed6\u611f\u67d3\u3002<\/span>\u6ce8\u610f\u76d1\u6d4b\u5e76\u8bc4\u4f30\u60a3\u8005\u662f\u5426\u6709\u53d1\u70ed\u6216\u5176\u4ed6\u611f\u67d3\u8ff9\u8c61\u548c\u75c7\u72b6\uff0c\u5e76\u9002\u5f53\u6cbb\u7597\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u8840\u7ec6\u80de\u51cf\u5c11\u75c7<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u6839\u636e\u5b9e\u9a8c\u5ba4\u8bc4\u4f30\u7684\u4e09\u7ea7\u6216\u56db\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\u75c7\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0827%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0810%\uff09\u548c\u8d2b\u8840\uff088%\uff09\uff0c\u5747\u5728\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u5728\u6cbb\u7597\u671f\u95f4\u6ce8\u610f\u76d1\u6d4b\u5b8c\u6574\u7684\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u5e76\u6839\u636e\u9700\u8981\u91c7\u7528\u751f\u957f\u56e0\u5b50\u6216\u8f93\u8840\u8fdb\u884c\u6cbb\u7597\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u7b2c\u4e8c\u6b21\u539f\u53d1\u6027\u6076\u6027\u80bf\u7624<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u7b2c\u4e8c\u6b21\u539f\u53d1\u6027\u6076\u6027\u80bf\u7624\uff0c\u5305\u62ec\u975e\u76ae\u80a4\u764c\uff0c\u51fa\u73b0\u57289%\u7684\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002<\/span>\u6700\u5e38\u89c1\u7684\u7b2c\u4e8c\u6b21\u539f\u53d1\u6027\u6076\u6027\u80bf\u7624\u662f\u76ae\u80a4\u764c\uff08\u57fa\u5e95\u7ec6\u80de\u764c\u548c\u9cde\u72b6\u76ae\u80a4\u7ec6\u80de\u764c\uff09\uff0c\u51fa\u73b0\u57286%\u7684\u60a3\u8005\u4e2d\u3002<\/span>\u5efa\u8bae\u60a3\u8005\u91c7\u7528\u9632\u6652\u63aa\u65bd\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u5fc3\u5f8b\u4e0d\u9f50<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u5fc3\u623f\u98a4\u52a8\u4e0e\u5fc3\u623f\u6251\u52a8\u51fa\u73b0\u57282%\u7684\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002<\/span>\u6709\u5fc3\u810f\u75be\u75c5\u5371\u9669\u56e0\u7d20\u3001\u9ad8\u8840\u538b\u4ee5\u53ca\u6025\u6027\u611f\u67d3\u7684\u60a3\u8005\u53ef\u80fd\u9762\u4e34\u66f4\u9ad8\u7684\u98ce\u9669\u3002<\/span>\u4e09\u7ea7\u53ca\u4ee5\u4e0a\u4e8b\u4ef6\u51fa\u73b0\u57280.6%\u7684\u63a5\u53d7BRUKINSA\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002<\/span>\u6ce8\u610f\u76d1\u6d4b\u5fc3\u623f\u98a4\u52a8\u4e0e\u5fc3\u623f\u6251\u52a8\u7684\u8ff9\u8c61\u548c\u75c7\u72b6\uff0c\u5e76\u914c\u60c5\u8fdb\u884c\u7ba1\u7406\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u80da\u80ce\u6bd2\u6027<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u6839\u636e\u52a8\u7269\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5b55\u5987\u63a5\u53d7BRUKINSA\u6cbb\u7597\u53ef\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\u3002<\/span>\u6000\u5b55\u5927\u9f20\u5728\u80ce\u513f\u5668\u5b98\u5f62\u6210\u671f\u95f4\u670d\u7528\u6cfd\u5e03\u66ff\u5c3c\uff0c\u836f\u7269\u66b4\u9732\u91cf\u4e3a\u60a3\u8005\u63a8\u8350\u5242\u91cf\uff08\u6bcf\u6b21160 mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u7528\u836f\uff09\u7684\u4e94\u500d\uff0c\u9020\u6210\u4e86\u5305\u62ec\u7578\u5f62\u5728\u5185\u7684\u80da\u80ce\u6bd2\u6027\u3002<\/span>\u5efa\u8bae\u5973\u6027\u5728\u63a5\u53d7BRUKINSA\u6cbb\u7597\u671f\u95f4\u907f\u514d\u6000\u5b55\uff0c\u6216\u7b49\u5230\u6cbb\u7597\u505c\u6b62\u540e\u81f3\u5c11\u4e00\u4e2a\u661f\u671f\uff1b<\/span>\u5efa\u8bae\u7537\u6027\u5728\u6cbb\u7597\u671f\u95f4\u907f\u514d\u4f7f\u5973\u6027\u6000\u5b55\uff0c\u6216\u7b49\u5230\u6cbb\u7597\u505c\u6b62\u540e\u81f3\u5c11\u4e00\u4e2a\u661f\u671f\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u82e5\u8fd9\u6b3e\u836f\u7269\u5728\u6000\u5b55\u671f\u95f4\u4f7f\u7528\uff0c\u6216\u8005\u60a3\u8005\u5728\u63a5\u53d7\u836f\u7269\u6cbb\u7597\u671f\u95f4\u6000\u5b55\uff0c\u5e94\u901a\u77e5\u60a3\u8005\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u5371\u9669\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u4e0d\u826f\u53cd\u5e94<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u5728\u591a\u4e8e10%\u7684\u63a5\u53d7BRUKINSA\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\u7684\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0853%\uff09\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\uff0839%\uff09\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0838%\uff09\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0830%\uff09\u3001\u8840\u7ea2\u86cb\u767d\u51cf\u5c11\uff0829%\uff09\u3001\u76ae\u75b9\uff0825%\uff09\u3001\u6de4\u9752\uff0823%\uff09\u3001\u8179\u6cfb\uff0820%\uff09\u3001\u54b3\u55fd(20%)\u3001\u808c\u8089\u9aa8\u9abc\u75bc\u75db\uff0819%\uff09\u3001\u80ba\u708e\uff0818%\uff09\u3001\u5c3f\u8def\u611f\u67d3\uff0813%\uff09\u3001\u8840\u5c3f\uff0812%\uff09\u3001\u4e4f\u529b\uff0811%\uff09\u3001\u4fbf\u79d8\uff0811%\uff09\u4ee5\u53ca\u51fa\u8840\uff0810%\uff09\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    CYP3A\u6291\u5236\u5242\uff1a<\/strong><\/strong> \u5f53BRUKINSA\u4e0e\u5f3a\u6548CYP3A\u6291\u5236\u5242\u540c\u65f6\u7ed9\u836f\u65f6\uff0c\u8c03\u6574BRUKINSA\u5242\u91cf\u81f3\u6bcf\u6b2180 mg\u3001\u6bcf\u65e5\u4e00\u6b21\u3002<\/span>\u5f53BRUKINSA\u4e0e\u6e29\u548cCYP3A\u6291\u5236\u5242\u540c\u65f6\u7ed9\u836f\u65f6\uff0c\u8c03\u6574BRUKINSA\u5242\u91cf\u81f3\u6bcf\u6b2180 mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    CYP3A \u8bf1\u5bfc\u5242\uff1a<\/strong><\/strong>\u907f\u514d\u4e0e\u6e29\u548c\u6216\u5f3a\u6548CYP3A\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<\/span> <\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u7279\u5b9a\u4eba\u7fa4<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u809d\u635f\u5bb3\uff1a<\/strong><\/strong>BRUKINSA\u9488\u5bf9\u6709\u4e25\u91cd\u809d\u635f\u5bb3\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u6b2180 mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u53e3\u670d\u7528\u836f\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u9002\u5e94\u75c7<\/strong><\/strong><\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    BRUKINSA\u662f\u4e00\u6b3e\u916a\u6c28\u9178\u9176\u6291\u5236\u5242\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u9879\u7597\u6cd5\u7684\u6210\u5e74\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005\u3002<\/span>\u6b64\u9879\u9002\u5e94\u75c7\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u3002<\/span>\u5728\u6b64\u9002\u5e94\u75c7\u4e2d\u7684\u7ee7\u7eed\u6279\u51c6\u53ef\u80fd\u53d6\u51b3\u4e8e\u786e\u8ba4\u6027\u8bd5\u9a8c\u4e2d\u786e\u8bc1\u4e0e\u548c\u4e34\u5e8a\u76ca\u5904\u63cf\u8ff0\u3002<\/span><\/section>\n<\/section>\n
                    \n


                    <\/p>\n<\/section>\n

                    \n
                    \u5b8c\u6574\u5904\u65b9\u4fe1\u606f<\/span><\/section>\n
                    beigene.com\/PDF\/BRUKINSAUSPI.pdf<\/strong><\/strong><\/span><\/section>\n
                    \u5305\u62ec\u60a3\u8005\u4fe1\u606f<\/span><\/section>\n
                    beigene.com\/PDF\/BRUKINSAUSPPI.pdf<\/span><\/section>\n
                    \u8bf7\u70b9\u51fb\u94fe\u63a5\u3002<\/span><\/section>\n<\/section>\n
                    \n
                    [i] BRUKINSA (zanubrutinib) Prescribing Information. beigene.com\/PDF\/BRUKINSAUSPI.pdf. BeiGene, Ltd; November 14, 2019.<\/span><\/section>\n
                    [ii] https:\/\/www.lls.org\/sites\/default\/files\/file_assets\/FS4_MCL_Facts_2018-final.pdf<\/span><\/section>\n
                    [iii] https:\/\/www.cancer.org\/cancer\/non-hodgkin-lymphoma\/about\/key-statistics.html<\/span><\/section>\n
                    [iv] Philip J. Bierman, James O. Armitage, in Goldman’s Cecil Medicine (Twenty Fourth Edition), 2012.<\/span><\/section>\n
                    [v] ABRAXANE\u00ae\u3001\u745e\u590d\u7f8e\u00ae\u548c\u7ef4\u8fbe\u838e\u00ae\u4e3a\u65b0\u57fa\u533b\u836f\u516c\u53f8\u7684\u6ce8\u518c\u5546\u6807\u3002<\/span><\/section>\n<\/section>\n
                    \"\u91cd\u5927\u7a81\u7834\uff01\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u65b0\u836f\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff01\u606d\u559c\u767e\u6d4e\u795e\u5dde\uff01\"<\/section>\n
                    \n
                    \n
                    \n
                    \n
                    \n
                    \n
                    \n
                    \n
                    \n
                    \n

                    \"\u91cd\u5927\u7a81\u7834\uff01\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u65b0\u836f\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff01\u606d\u559c\u767e\u6d4e\u795e\u5dde\uff01\"<\/p>\n

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                    <\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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