{"id":122317,"date":"2020-02-24T11:05:36","date_gmt":"2020-04-21T00:59:21","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/122317\/"},"modified":"2020-04-21T08:59:22","modified_gmt":"2020-04-21T00:59:22","slug":"2c6b30d68f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/122317\/","title":{"rendered":"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u4e0a\u6d77\u590d\u661f\u533b\u836f\uff08\u96c6\u56e2\uff09\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5173\u4e8e\u590d\u661f\u51ef\u7279\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u83b7\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u53d7\u7406\u7684\u516c\u544a   &nbsp;<\/span><\/section>\n<section style=\"text-align: center;margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2020\/04\/3-1587430762.png\" alt=\"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143\" title=\"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143\"  \/><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\"><strong><span style=\"color: rgb(217, 33, 66);\">\u4e00\u3001\u6982\u51b5<\/span><\/strong><\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0c\u4e0a\u6d77\u590d\u661f\u533b\u836f\uff08\u96c6\u56e2\uff09\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u672c\u516c\u53f8\u201d\uff09\u6295\u8d44\u7684\u5408\u8425\u516c\u53f8\u590d\u661f\u51ef\u7279\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u622a\u81f3\u672c\u516c\u544a\u65e5\uff0c\u672c\u516c\u53f8\u5168\u8d44\u5b50\u516c\u53f8\u4e0a\u6d77\u590d\u661f\u533b\u836f\u4ea7\u4e1a\u53d1\u5c55\u6709\u9650\u516c\u53f8\u6301\u6709\u5176 50%\u80a1\u6743\uff1b<\/span><span style=\"font-size: 15px;\">\u4ee5\u4e0b\u7b80\u79f0\u201c\u590d\u661f\u51ef\u7279\u201d\uff09\u6536\u5230\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\uff08\u53d7\u7406\u53f7\uff1a<\/span><span style=\"font-size: 15px;\">CXSS2000006 \u56fd\uff09\uff0c\u5176\u76ca\u57fa\u5229\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u62df\u5b9a\uff09\uff08\u5373\u6297\u4eba CD19 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15px;\"><strong>\u4e8c\u3001\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\u7684\u57fa\u672c\u60c5\u51b5<\/strong><\/span><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\"><strong>\u4ea7\u54c1\u540d\u79f0\uff1a<\/strong><\/span><span style=\"font-size: 15px;\">\u76ca\u57fa\u5229\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u62df\u5b9a\uff09\uff08\u4ee3\u53f7 FKC876\uff0c\u6297\u4eba CD19 CAR-T \u7ec6\u80de\u6ce8\u5c04\u6db2\uff09<\/span><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\"><strong>\u53d7\u7406\u53f7\uff1a<\/strong><\/span><span style=\"font-size: 15px;\">CXSS2000006 \u56fd<\/span><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\"><strong>\u7533\u8bf7\u4e8b\u9879\uff1a<\/strong><\/span><span style=\"font-size: 15px;\">\u65b0\u836f\u7533\u8bf7\uff1a<\/span><span style=\"font-size: 15px;\">\u7279\u6b8a\u5ba1\u6279\u7a0b\u5e8f\uff1b<\/span><span style=\"font-size: 15px;\">\u9644\u52a0\u7533\u8bf7\u4e8b\u9879\u5176\u4ed6<\/span><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\"><strong>\u7533\u8bf7\u4eba\uff1a<\/strong><\/span><span style=\"font-size: 15px;\">\u590d\u661f\u51ef\u7279<\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\"><strong>\u7ed3\u8bba\uff1a<\/strong><\/span><span style=\"font-size: 15px;\">\u4e88\u4ee5\u53d7\u7406<\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"color: rgb(217, 33, 66);font-size: 15px;\"><strong>\u4e09\u3001\u8be5\u4ea7\u54c1\u7684\u7814\u7a76\u60c5\u51b5<\/strong><\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u8be5\u4ea7\u54c1\u5373\u7f8e\u56fd Kite Pharma, Inc.\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cKite Pharma\u201d\uff0c\u7cfb Gilead Sciences, Inc.\u7684\u63a7\u80a1\u5b50\u516c\u53f8\uff09\u7684\u6297\u4eba CD19 CAR-T \u7ec6\u80de\u6ce8\u5c04\u6db2\uff08\u5546\u54c1\u540d YESCARTA\uff09\uff0c\u4e3b\u8981\u7528\u4e8e\u590d\u53d1\u96be\u6cbb\u6027\u6210\u4eba\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u5305\u62ec\u5f25\u6f2b\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u975e\u7279\u6307\u578b\u3001 \u539f\u53d1\u6027\u7eb5\u9694 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08PMBCL\uff09\u3001\u9ad8\u7ea7\u522b B \u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u6ee4\u6ce1\u6dcb\u5df4\u7624\u8f6c\u5316\u7684 DLBCL\uff09 \u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size: 15px;\">2017 \u5e74 10 \u6708\uff0cYESCARTA\u83b7\u7f8e\u56fd FDA\uff08\u5373\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff09\u6279\u51c6\u4e8e\u7f8e\u56fd\u4e0a\u5e02\uff0c\u662f\u7f8e\u56fd FDA \u6279\u51c6\u7684\u9996\u6b3e\u9488\u5bf9\u7279\u5b9a\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684 CAR-T \u7ec6\u80de\u836f\u7269\u3002<\/span><span style=\"font-size: 15px;\">2018 \u5e74 8 \u6708\uff0cYESCARTA\u83b7\u6b27\u6d32 EMA\uff08\u5373\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff09\u6279\u51c6\u4e8e\u6b27\u6d32\u4e0a\u5e02\u3002<\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u8be5\u4ea7\u54c1\u7531\u590d\u661f\u51ef\u7279\u4ece Kite Pharma \u5f15\u8fdb\u3001\u83b7\u5f97\u5728\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u548c \u6fb3\u95e8\u7279\u522b\u884c\u653f\u533a\u7684\u6280\u672f\u53ca\u5546\u4e1a\u5316\u6743\u5229\uff0c\u5e76\u62df\u4e8e\u4e2d\u56fd\u5883\u5185\uff08\u4e0d\u5305\u62ec\u6e2f\u6fb3\u53f0\u5730\u533a\uff0c\u4e0b\u540c\uff09\u8fdb\u884c\u672c\u5730\u5316\u751f\u4ea7\u3002<\/span><span style=\"font-size: 15px;\">2018 \u5e74 8 \u6708\uff0c\u8be5\u4ea7\u54c1\u83b7\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\u3002<\/span><span style=\"font-size: 15px;\">\u622a\u81f3\u672c\u516c\u544a\u65e5\uff0c\u8be5\u4ea7\u54c1\u5df2\u5b8c\u6210\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u590d\u53d1\u96be\u6cbb\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u56fd\u5883\u5185\u6865\u63a5\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><span style=\"font-size: 15px;\">&nbsp;<\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"font-size: 15px;\">\u622a\u81f3\u672c\u516c\u544a\u65e5\uff0c\u4e2d\u56fd\u5883\u5185\u5c1a\u65e0\u4e0e\u8be5\u4ea7\u54c1\u5177\u6709\u76f8\u540c\u9776\u70b9\u7684\u540c\u7c7b\u836f\u7269\u83b7\u6279\u4e0a\u5e02\u3002<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u5168 \u7403\u5df2\u83b7\u6279\u4e0a\u5e02\u7684\u53e6\u4e00\u6b3e CAR-T \u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4ea7\u54c1\u662f Novartis Pharma Schweiz AG \u7684 KYMRIAH\uff0c\u5176\u4e0e\u590d\u661f\u51ef\u7279 FKC876 \u7684\u9776\u70b9\u540c\u4e3a CD19\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u548c\u5e74\u8f7b\u6210\u4eba\uff082\u81f3 25 \u5c81\uff09\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u53ca\u6210\u5e74\u4eba\u590d\u53d1\/\u96be\u6cbb\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u5305\u62ec\u5f25\u6f2b \u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u8f6c\u5316\u578b\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u548c\u539f\u53d1\u7eb5\u9694 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff09\u3002\u6839\u636e Gilead Sciences, Inc.\u3001Novartis Pharma Schweiz AG \u5df2\u516c\u5e03\u7684\u8d22\u52a1\u62a5\u544a\uff0c2019 \u5e74\u5ea6\uff0c YESCARTA\u3001KYMRIAH\u5168\u7403\u9500\u552e\u989d\u5206\u522b\u7ea6\u4e3a 4.56 \u4ebf\u7f8e\u5143\u30012.78 \u4ebf\u7f8e\u5143\u3002&nbsp;\u622a\u81f3 2020 \u5e74 1 \u6708\uff0c\u590d\u661f\u51ef\u7279\u73b0\u9636\u6bb5\u9488\u5bf9\u8be5\u4ea7\u54c1\u7d2f\u8ba1\u7814\u53d1\u6295\u5165\u7ea6\u4e3a\u4eba\u6c11\u5e01 47,400 \u4e07\u5143\uff08\u542b\u4e13\u5229\u548c\u6280\u672f\u8bb8\u53ef\u8d39\u7528\uff0c\u672a\u7ecf\u5ba1\u8ba1\uff09\u3002<\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"color: rgb(217, 33, 66);font-size: 15px;\"><strong>\u56db\u3001\u98ce\u9669\u63d0\u793a<\/strong><\/span><\/section>\n<section style=\"margin-bottom: 15px;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u8be5\u65b0\u836f\u4e8e\u4e2d\u56fd\u5883\u5185\u8fdb\u884c\u5546\u4e1a\u5316\u751f\u4ea7\u524d\uff0c\u5c1a\u9700\uff08\u5176\u4e2d\u5305\u62ec\uff09\u83b7\u5f97\u836f\u54c1\u6279\u51c6\u6587\u53f7\u3001\u751f\u4ea7\u8bbe\u65bd\u901a\u8fc7 GMP \u8ba4\u8bc1\u7b49\u3002<\/span><span style=\"font-size: 15px;\">\u672c\u6b21\u53d6\u5f97\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\u4e0d\u4f1a\u5bf9\u672c\u96c6\u56e2\uff08\u5373\u672c\u516c\u53f8\u53ca\u63a7 \u80a1\u5b50\u516c\u53f8\/\u5355\u4f4d\uff09\u73b0\u9636\u6bb5\u4e1a\u7ee9\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002<\/span><span style=\"font-size: 15px;\">&nbsp;\u7531\u4e8e\u533b\u836f\u4ea7\u54c1\u7684\u884c\u4e1a\u7279\u70b9\uff0c\u5404\u7c7b\u4ea7\u54c1\/\u836f\u54c1\u7684\u6295\u4ea7\u53ca\u672a\u6765\u6295\u4ea7\u540e\u7684\u5177\u4f53\u9500\u552e\u60c5\u51b5\u53ef\u80fd\u53d7\u5230\u5e02\u573a\u73af\u5883\u53d8\u5316\u7b49\u56e0\u7d20\u5f71\u54cd\uff0c\u5177\u6709\u8f83\u5927\u4e0d\u786e\u5b9a\u6027\uff0c\u656c\u8bf7\u5e7f\u5927\u6295\u8d44\u8005\u6ce8\u610f\u6295\u8d44\u98ce\u9669\u3002<\/span><span style=\"font-size: 15px;\">&nbsp;\u7279\u6b64\u516c\u544a\u3002<\/span><\/section>\n<section style=\"text-align: right;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u4e0a\u6d77\u590d\u661f\u533b\u836f\uff08\u96c6\u56e2\uff09\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/span><\/section>\n<section style=\"text-align: right;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u8463\u4e8b\u4f1a<\/span><\/section>\n<section style=\"text-align: right;margin-left: 8px;margin-right: 8px;\"><span style=\"font-size: 15px;\">\u4e8c\u96f6\u4e8c\u96f6\u5e74\u4e8c\u6708\u4e8c\u5341\u56db\u65e5<\/span><\/section>\n<section style=\"max-width: 100%;min-height: 1em;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);text-align: center;letter-spacing: 0.54px;margin-left: 8px;margin-right: 8px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"          style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2020\/04\/9-1587430762.jpeg\" alt=\"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143\" title=\"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143\"  \/><\/section>\n<section mpa-from-tpl=\"t\" style=\"max-width: 100%;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);letter-spacing: 0.54px;font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  mpa-from-tpl=\"t\"   style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\"  style=\"max-width: 100%;width: 574px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\"    style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section mpa-from-tpl=\"t\" style=\"margin: 30px auto;padding: 25px 20px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;background-color: rgb(247, 247, 247);\">\n<section mpa-from-tpl=\"t\"  style=\"max-width: 100%;color: rgb(79, 79, 79);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;min-height: 1em;text-align: center;margin-left: 8px;margin-right: 8px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"           style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 79px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2020\/04\/3-1587430762.jpeg\" alt=\"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143\" title=\"\u91cd\u78c5\uff01\u9996\u6b3eCar-T\u7533\u62a5\u4e0a\u5e02\uff0c\u6295\u5165\u8fd15\u4ebf\u5143\"  \/><\/section>\n<section style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;margin-left: 8px;margin-right: 8px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);letter-spacing: 1px;font-size: 15px;box-sizing: 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