{"id":122603,"date":"2020-03-18T06:24:50","date_gmt":"2020-04-21T01:02:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/122603\/"},"modified":"2020-04-21T09:02:52","modified_gmt":"2020-04-21T01:02:52","slug":"c65d5d343b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/122603\/","title":{"rendered":"CDE\u53d1\u5e03\u300a\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4eff\u5236\u836f\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u5f81\u6c42\u610f\u89c1\uff0c\u8d28\u91cf\u5bf9\u6bd4>BE>\u6216\u4e34\u5e8a"},"content":{"rendered":"
\n
\u5bfc\u8bfb\uff1a<\/span><\/strong><\/span><\/section>\n
\u4eca\u5929\uff0cCDE\u53d1\u5e03\u300a\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4eff\u5236\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff08\u5f81\u6c42\u610f\u89c1\u7a3f<\/span>\u3002\u5bf9\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u4eff\u5236\uff0c\u63d0\u51fa\u4e86\u7814\u53d1\u6280\u672f\u8981\u6c42\uff0c\u4e5f\u53ef\u4ee5\u7ed9\u7c7b\u4f3c\u8102\u8d28\u4f53\u63d0\u4f9b\u53c2\u8003\uff01<\/span><\/section>\n
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<\/span><\/p>\n

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\u8054\u7cfb\u4eba\uff1a\u7ae0\u4fca\u9e9f\u3001\u90a3\u99a8\u7af9<\/span><\/p>\n

\u90ae  \u7bb1\uff1a<\/span>zhangjl@cde.org.cn<\/span>\u3001<\/span>naxzh@cde.org.cn<\/span><\/p>\n

\u611f\u8c22\u60a8\u7684\u53c2\u4e0e\u548c\u5927\u529b\u652f\u6301\u3002<\/span><\/p>\n

\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3<\/span><\/p>\n

2020\u5e743\u670817\u65e5<\/span><\/p>\n

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\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u4e00<\/span><\/strong>\u3001<\/span><\/strong>\u6982\u8ff0<\/span><\/strong><\/span><\/section>\n
\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u662f\u91c7\u7528\u786b\u9178\u94f5\u68af\u5ea6\u6cd5\u5c06\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u5305\u88f9\u4e8e<\/span>PEG\u5316\u8102\u8d28\u4f53\u5185\u5f62\u6210\u7684\u7279\u6b8a\u6ce8\u5c04\u5242\u3002<\/span><\/span><\/section>\n
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\u672c\u6307\u5bfc\u539f\u5219\u4ec5\u4ee3\u8868\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u76ee\u524d\u5bf9\u4e8e\u672c\u54c1\u7684\u89c2\u70b9\u548c\u8ba4\u8bc6\u3002\u5728\u7b26\u5408\u73b0\u884c\u6cd5\u89c4\u7684\u8981\u6c42\u4e0b\uff0c\u53ef\u91c7\u7528\u66ff\u4ee3\u7684\u7814\u7a76\u65b9\u6cd5\uff0c\u5efa\u8bae\u63d0\u4f9b\u8be6\u7ec6\u7684\u7814\u7a76\u8d44\u6599\u6216\u4e0e\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u6c9f\u901a\u3002<\/span><\/section>\n
\u4e8c\u3001\u6574\u4f53\u7814\u7a76<\/span><\/strong>\u601d\u8def<\/span><\/strong><\/span><\/section>\n
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\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4e3a\u7ecf\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u8102\u8d28\u4f53\u5236\u5242\uff0c\u5e94\u57fa\u4e8e\u4ea7\u54c1\u7279\u5f81\uff0c\u91c7\u53d6\u9010\u6b65\u9012\u8fdb\u7684\u5bf9\u6bd4\u7814\u7a76\u7b56\u7565\uff0c\u9996\u5148\u8fdb\u884c\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u836f\u5b66\u548c\u975e\u4e34\u5e8a\u7684\u5168\u9762\u5bf9\u6bd4\u7814\u7a76\uff1b\u7136\u540e\u8fdb\u884c\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff1b\u5fc5\u8981\u65f6\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\u3002\u82e5\u836f\u5b66\u7814\u7a76\u548c\uff08\u6216\uff09\u975e\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u4e0d\u4e00\u81f4\uff0c\u5efa\u8bae\u4f18\u5316\u540e\u91cd\u65b0\u5f00\u5c55\u7814\u7a76<\/span>1<\/span><\/sup>\u3002<\/span><\/span><\/section>\n
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\u4e09\u3001<\/span><\/strong>\u6280\u672f\u8981\u6c42<\/span><\/strong><\/span><\/section>\n
\uff08\u4e00<\/span><\/strong>\uff09<\/span><\/strong>\u836f\u5b66\u7814\u7a76<\/span><\/strong><\/span><\/section>\n
1\u3001\u5904\u65b9<\/span><\/strong><\/span><\/section>\n
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\u6c22\u5316\u5927\u8c46\u78f7\u8102\u9170\u80c6\u78b1\uff08<\/span>HSPC\uff09\u3001\u80c6\u56fa\u9187\u3001\u7532\u6c27\u57fa\u805a\u4e59\u4e8c\u9187\u78f7\u8102\u9170\u4e59\u9187\u80fa\uff08<\/span>MPEG-DSPE\uff09\u662f\u672c\u54c1\u7684\u5173\u952e\u6210\u5206\uff0c\u5e94\u6309\u76f8\u5173\u8981\u6c42\u8fdb\u884c\u767b\u8bb0\u548c\u5173\u8054\uff0c\u6216\u7531\u5236\u5242\u6ce8\u518c\u7533\u8bf7\u4eba\u4e00\u5e76\u63d0\u4f9b\u7814\u7a76\u8d44\u6599<\/span><\/span>3<\/span><\/sup>\u3002\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u9009\u62e9\u76f8\u540c\u6765\u6e90\uff08\u5929\u7136\u7684\u6216\u5408\u6210\u7684\uff09\u7684\u8102\u8d28\u8f85\u6599\uff0c\u5236\u5b9a\u4e25\u683c\u7684\u5185\u63a7\u6807\u51c6\uff0c\u5e76\u63d0\u4f9b\u7814\u7a76\u8d44\u6599\u8bc1\u660e\u4eff\u5236\u836f\u6240\u91c7\u7528\u7684\u8102\u8d28\u8f85\u6599\u4e0e\u53c2\u6bd4\u5236\u5242\u4e2d\u7684\u8102\u8d28\u8f85\u6599\u76f8\u4f3c\uff08\u5982\uff0c\u5404\u7ec4\u5206\u6bd4\u4f8b\uff09\u3002<\/span><\/span><\/section>\n
2\u3001\u5236\u5907\u5de5\u827a<\/span><\/strong><\/span><\/section>\n
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\u672c\u54c1\u5de5\u827a\u8f83\u4e3a\u590d\u6742\uff0c\u5e94\u63d0\u4f9b\u8be6\u7ec6\u7684\u751f\u4ea7\u5de5\u827a\u5f00\u53d1\u7814\u7a76\u8d44\u6599\u548c\u5de5\u827a\u9a8c\u8bc1\u8d44\u6599\uff08\u5305\u62ec\u65e0\u83cc\u5de5\u827a\u9a8c\u8bc1\u8d44\u6599\uff09\u3002\u5efa\u8bae\u5236\u5b9a\u5408\u7406\u7684\u751f\u4ea7\u8fc7\u7a0b\u63a7\u5236\u7b56\u7565\uff0c\u5982\u5173\u952e\u6b65\u9aa4\u7684\u751f\u4ea7\u65f6\u9650\u3001\u5173\u952e\u4e2d\u95f4\u4f53\u7684\u8d28\u91cf\u63a7\u5236\u6807\u51c6\u548c\u4fdd\u6301\u65f6\u9650\u7b49\u3002<\/span><\/section>\n
\u5e94\u7279\u522b\u5173\u6ce8\u751f\u4ea7\u5de5\u827a\u548c\u6279\u91cf\u5bf9\u4ea7\u54c1\u8d28\u91cf\u53ef\u63a7\u6027\u7684\u5f71\u54cd\uff0c\u6ce8\u518c\u6279\u548c\u5546\u4e1a\u6279\u7684\u751f\u4ea7\u5de5\u827a\u53ca\u6279\u91cf\u539f\u5219\u4e0a\u5e94\u4fdd\u6301\u4e00\u81f4<\/span>5<\/span><\/sup>\u3002<\/span><\/span><\/section>\n
3<\/span><\/strong>\u3001\u8d28\u91cf\u7814\u7a76<\/span><\/strong><\/span><\/section>\n
\u4eff\u5236\u836f\u5e94\u901a\u8fc7\u4f53\u5916\u8868\u5f81\u8bc1\u660e\u5176\u4e0e\u53c2\u6bd4\u5236\u5242\u5173\u952e\u8d28\u91cf\u5c5e\u6027\uff08<\/span>CQAs\uff09\u4e00\u81f4\uff0c\u9664\u6ce8\u5c04\u5242\u4e00\u822c\u8d28\u91cf\u5c5e\u6027\u5916\uff0c\u8fd8\u5e94\u5173\u6ce8\u4ee5\u4e0b<\/span>CQAs<\/span>8<\/span><\/sup>\uff1a<\/span><\/span><\/section>\n
1.\u8102\u8d28\u4f53\u7ec4\u6210\uff1a\u5305\u62ec\u78f7\u8102\u542b\u91cf\u3001\u6e38\u79bb\u7684\u548c\u5305\u5c01\u7684\u836f\u7269\u542b\u91cf\u3001\u603b\u786b\u9178\u6839\u548c\u94f5\u6839\u6d53\u5ea6\u3001\u5185\u76f8\u4e2d\u786b\u9178\u6839\u548c\u94f5\u6839\u6d53\u5ea6\u3001\u7ec4\u6c28\u9178\u6d53\u5ea6\u548c\u8517\u7cd6\u6d53\u5ea6\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\u5e76\u8ba1\u7b97\u836f\u8102\u6bd4\u3002\u4eff\u5236\u836f\u5404\u9879\u6307\u6807\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
2.\u5305\u5c01\u836f\u7269\u7684\u72b6\u6001\uff1a\u836f\u7269\u4e3b\u8981\u4ee5\u591a\u67d4\u6bd4\u661f\u786b\u9178\u76d0\u6c89\u6dc0\u7684\u5f62\u5f0f\u5b58\u5728\u4e8e\u8102\u8d28\u4f53\u5185\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff08\u5982\uff0c\u7535\u955c\u6cd5\u548c<\/span>X\u5c04\u7ebf\u884d\u5c04\u6cd5\u7b49\uff09\uff0c\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
3.\u8102\u8d28\u4f53\u5185\u73af\u5883\uff1a\u5305\u62ec\u5185\u76f8\u4f53\u79ef\u3001\u5185\u5916\u76f8<\/span>pH\u68af\u5ea6\u5dee\u3001\u5185\u76f8\u4e2d\u786b\u9178\u6839\u548c\u94f5\u6839\u6d53\u5ea6\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff0c\u4eff\u5236\u836f\u5404\u9879\u6307\u6807\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
4.\u4f53\u5916\u91ca\u653e\u5ea6\uff1a\u4f53\u5916\u91ca\u653e\u5ea6\u662f\u672c\u54c1\u7684\u91cd\u8981\u8d28\u63a7\u6307\u6807\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u6761\u4ef6\u548c\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff0c\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
5.\u8102\u8d28\u4f53\u5f62\u6001\u548c\u8102\u819c\u5c42\u6570\uff1a\u8102\u8d28\u4f53\u7684\u8f7d\u836f\u91cf\u548c\u91ca\u653e\u5ea6\u53ef\u80fd\u53d7\u8102\u8d28\u4f53\u5f62\u6001\u548c\u8102\u819c\u5c42\u6570\u7684\u5f71\u54cd\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff08\u5982\uff0c\u7535\u955c\u6cd5\uff09\uff0c\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
6.\u8102\u819c\u7684\u76f8\u53d8\u6e29\u5ea6\uff1a\u8102\u819c\u7684\u76f8\u53d8\u6e29\u5ea6\u5f71\u54cd\u8102\u8d28\u4f53\u53cc\u5c42\u819c\u7684\u7a33\u5b9a\u6027\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff08\u5982\uff0c\u5dee\u793a\u626b\u63cf\u91cf\u70ed\u6cd5\uff09\uff0c\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
7.\u7c92\u5ea6\u548c\u7c92\u5ea6\u5206\u5e03\uff1a\u7c92\u5ea6\u548c\u7c92\u5ea6\u5206\u5e03\u662f\u672c\u54c1\u7684\u91cd\u8981\u8d28\u63a7\u6307\u6807\u3002\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff0c\u4eff\u5236\u836f\u7684\u7c92\u5ea6\u5206\u5e03\uff08<\/span>D10\u3001<\/span>D50\u3001<\/span>D90\uff09\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002\u540c\u65f6\uff0c\u5efa\u8bae\u57fa\u4e8e<\/span>D50\u548cSPAN[(D90-D10)\/D50]\u6216\u591a\u5206\u6563\u7cfb\u6570\uff0c\u91c7\u7528\u7fa4\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u5206\u6790\u65b9\u6cd5\u8fdb\u884c\u7c92\u5ea6\u548c\u7c92\u5ea6\u5206\u5e03\u7684\u5bf9\u6bd4\uff08\u4eff\u5236\u836f\u548c\u53c2\u6bd4\u5236\u5242\u5404\u9009\u4e09\u6279\uff0c\u6bcf\u6279\u4e0d\u5c11\u4e8e<\/span>10\u74f6\uff0c\u6bcf\u74f6\u5e73\u884c\u6d4b\u5b9a\u4e0d\u5c11\u4e8e3\u6b21\uff09\uff0c\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u5e94\u7b49\u6548\u3002<\/span><\/span><\/section>\n
8.PEG\u539a\u5ea6\uff08\u8102\u8d28\u4f53\u8868\u9762PEG\u5bc6\u5ea6\uff09\uff1a\u91c7\u7528\u7532\u6c27\u57fa\u805a\u4e59\u4e8c\u9187\uff08<\/span>MPEG\uff09\u5bf9\u78f7\u8102\u9170\u4e59\u9187\u80fa\uff08<\/span>DSPE\uff09\u8fdb\u884c\u4fee\u9970\uff0c\u4e00\u65b9\u9762\u53ef\u589e\u52a0\u8102\u819c\u7684\u673a\u68b0\u5f3a\u5ea6\uff1b\u53e6\u4e00\u65b9\u9762\u53ef\u907f\u514d\u8102\u8d28\u4f53\u88ab\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf\uff08<\/span>MPS\uff09\u6e05\u9664\uff0c\u4ee5\u589e\u52a0\u5176\u5728\u8840\u6db2\u4e2d\u7684\u5faa\u73af\u65f6\u95f4\u3002\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\uff0c\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
9.Zeta\u7535\u4f4d\uff1a\u8868\u9762\u7535\u8377\u53ef\u7ef4\u6301\u8102\u8d28\u4f53\u7684\u7a33\u5b9a\u6027\uff0c\u540c\u65f6\u5f71\u54cd\u8102\u8d28\u4f53\u7684\u7ec4\u7ec7\u5206\u5e03\u3001\u7ec6\u80de\u6444\u53d6\u548c\u6e05\u9664\uff0c\u5e94\u9009\u62e9\u9002\u5f53\u7684\u65b9\u6cd5\u548c\u4ecb\u8d28\u8fdb\u884c\u7814\u7a76\uff0c\u4eff\u5236\u836f\u5e94\u4e0e\u53c2\u6bd4\u5236\u5242\u4e00\u81f4\u3002<\/span><\/span><\/section>\n
10.\u591a\u79cd\u6761\u4ef6\u4e0b\u7684\u4f53\u5916\u6cc4\u6f0f\uff1a\u4e3a\u4fdd\u8bc1\u80bf\u7624\u7ec6\u80de\u7684\u7b49\u6548\uff0c\u5e94\u6a21\u62df\u4f53\u5185\u73af\u5883\u6761\u4ef6\u8fdb\u884c\u836f\u7269\u6cc4\u6f0f\u7684\u7814\u7a76\uff0c\u63a8\u8350\u7684\u8bd5\u9a8c\u6761\u4ef6\u89c1\u4e0b\u8868\uff1a<\/span><\/span><\/section>\n
\"CDE\u53d1\u5e03\u300a\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4eff\u5236\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u5f81\u6c42\u610f\u89c1\uff0c\u8d28\u91cf\u5bf9\u6bd4>BE>\u6216\u4e34\u5e8a\"<\/section>\n
\u5e94\u63d0\u4f9b\u5404\u9879\u5bf9\u6bd4\u7814\u7a76\u6240\u91c7\u7528\u7684\u5206\u6790\u65b9\u6cd5\u548c\u5fc5\u8981\u7684\u65b9\u6cd5\u5b66\u9a8c\u8bc1\u8d44\u6599\uff0c\u660e\u786e\u8bc4\u4ef7\u6307\u6807\u3001\u6807\u51c6\u53ca\u786e\u5b9a\u4f9d\u636e\u3002<\/span><\/section>\n
\u5efa\u8bae\u91c7\u7528\u81f3\u5c11\u4e09\u6279\u5546\u4e1a\u5316\u89c4\u6a21\u5de5\u827a\u751f\u4ea7\u7684\u4eff\u5236\u54c1\u4e0e\u591a\u6279\u53c2\u6bd4\u5236\u5242\u8fdb\u884c\u4f53\u5916\u5bf9\u6bd4\u7814\u7a76\u3002<\/span><\/section>\n
4<\/span><\/strong>\u3001<\/span><\/strong>\u7a33\u5b9a\u6027\u7814\u7a76<\/span><\/strong><\/span><\/section>\n
\u5e94\u8fdb\u884c\u5e38\u89c4\u7a33\u5b9a\u6027\u8003\u5bdf\uff0c\u5e76\u7ed3\u5408\u4ea7\u54c1\u8bf4\u660e\u4e66\u5f00\u5c55\u4f7f\u7528\u4e2d\u4ea7\u54c1\u7a33\u5b9a\u6027\u7814\u7a76\u3002\u7a33\u5b9a\u6027\u8003\u5bdf\u6307\u6807\u9664\u666e\u901a\u6ce8\u5c04\u5242<\/span>CQAs\u5916\uff0c\u8fd8\u5e94\u5305\u62ec\u5fae\u7c92\u5236\u5242\u76f8\u5173\u7684<\/span>CQAs\u3002<\/span><\/span><\/section>\n
\u5e94\u7ed3\u5408\u4ea7\u54c1\u7279\u70b9\u3001\u7a33\u5b9a\u6027\u3001\u5305\u6750\u76f8\u5bb9\u6027\u548c\u5bb9\u5668\u5bc6\u5c01\u6027\u7b49\u7814\u7a76\u7ed3\u679c\u8bc1\u660e\u5305\u6750\u9009\u62e9\u5408\u7406\u3002\u5305\u6750\u76f8\u5bb9\u6027\u5e94\u53c2\u7167\u76f8\u5173\u6307\u5bfc\u539f\u5219\u8fdb\u884c\u3002<\/span><\/section>\n
\uff08\u4e8c\uff09\u975e\u4e34\u5e8a\u7814\u7a76<\/span><\/strong><\/span><\/section>\n
\u7279\u6b8a\u6ce8\u5c04\u5242\u8fdb\u5165\u4f53\u5185\u540e\u901a\u5e38\u5b58\u5728\u91ca\u836f\u8fc7\u7a0b\u548c\u4f53\u6db2\u6210\u5206\u5438\u9644\u7b49\u56e0\u7d20\uff0c\u56e0\u6b64\uff0c\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u5904\u65b9\u548c\u5de5\u827a\u7684\u5dee\u5f02\u53ef\u80fd\u5bfc\u81f4\u836f\u7269\u4f53\u5185\u836f\u4ee3\u52a8\u529b\u5b66\u884c\u4e3a\u53d1\u751f\u6539\u53d8\uff0c\u4ece\u800c\u5e26\u6765\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u53d8\u5316\uff0c\u5efa\u8bae\u5728\u975e\u4e34\u5e8a\u9636\u6bb5\u9009\u62e9\u5408\u9002\u7684\u52a8\u7269\u79cd\u5c5e\u5f00\u5c55\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u6bd4\u8f83\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u7ec4\u7ec7\u5206\u5e03\u7814\u7a76\uff0c\u5145\u5206\u63d0\u793a\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u5728\u836f\u4ee3\u52a8\u529b\u5b66\u884c\u4e3a\u7684\u4e00\u81f4\u6027\uff0c\u5728\u6b64\u57fa\u7840\u4e0a\u5f00\u5c55\u5236\u5242\u5b89\u5168\u6027\u8bd5\u9a8c\u3002\u9f13\u52b1\u540c\u65f6\u8bbe\u7f6e\u666e\u901a\u591a\u67d4\u6bd4\u661f\u5bf9\u7167\u7ec4\uff0c\u786e\u8ba4\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u5236\u5242\u548c\u666e\u901a\u591a\u67d4\u6bd4\u661f\u6ce8\u5c04\u6db2\u5728\u52a8\u7269\u4f53\u5185\u836f\u4ee3\u7279\u5f81\u5dee\u5f02\u3002<\/span><\/section>\n
1.\u901a\u5e38\u9009\u62e9\u975e\u556e\u9f7f\u7c7b\u52a8\u7269\u8fdb\u884c\u836f\u4ee3\u52a8\u529b\u5b66\u6bd4\u8f83\u7814\u7a76\u3002\u91c7\u7528\u62df\u5b9a\u4e34\u5e8a\u5242\u91cf\u548c\u7ed9\u836f\u9014\u5f84\uff0c\u8bbe\u7f6e\u53c2\u6bd4\u5236\u5242\u7ec4\uff0c\u6d4b\u5b9a\u8840\u6d46\u4e2d\u603b\u591a\u67d4\u6bd4\u661f\u542b\u91cf\u548c\u6e38\u79bb\u7684\u591a\u67d4\u6bd4\u661f\u6d53\u5ea6\uff0c\u83b7\u5f97<\/span>t1\/2\u3001<\/span>Cmax\u3001AUC\u3001Vz\u3001<\/span>Cl\u3001<\/span>MRT\u7b49\u4e3b\u8981\u836f\u4ee3\u53c2\u6570\u7684\u6bd4\u8f83\u7814\u7a76\u7ed3\u679c\u3002\u9274\u4e8e\u901a\u5e38\u53ea\u6709\u91ca\u653e\u836f\u7269\u624d\u80fd\u5728\u4f53\u5185\u53d1\u6325\u6d3b\u6027\uff0c\u5728\u8fdb\u884c\u8840\u836f\u6d53\u5ea6\u6d4b\u5b9a\u65f6\u9700\u5206\u522b\u8003\u5bdf\u7ed3\u5408\u578b\u836f\u7269\u548c\u91ca\u653e\u836f\u7269\u7684\u66b4\u9732\u91cf\u3002<\/span><\/span><\/section>\n
2.\u91c7\u7528\u8377\u7624\u52a8\u7269\u5f00\u5c55\u7ec4\u7ec7\u5206\u5e03\u7684\u6bd4\u8f83\u7814\u7a76\uff0c\u5242\u91cf\u901a\u5e38\u8bbe\u7f6e\u4e3a\u6709\u6548\u5242\u91cf\uff0c\u81f3\u5c11\u6d4b\u5b9a\u7ed9\u836f\u540e\u8840\u6db2\u3001\u80bf\u7624\u7ec4\u7ec7\u3001\u5fc3\u810f\u548c\u5185\u8d28\u7f51\u8f83\u4e3a\u4e30\u5bcc\u7684\u7ec4\u7ec7\uff08\u5982\u809d\u3001\u80be\uff09\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u6bd4\u8f83\u6b63\u5e38\u7ec4\u7ec7\u548c\u80bf\u7624\u7ec4\u7ec7\u4e0e\u8840\u6db2\u4e2d\u7684\u591a\u67d4\u6bd4\u661f\u836f\u7269\u66b4\u9732\u91cf\u53ca\u5176\u6bd4\u503c\u7684\u5dee\u5f02\uff0c\u540c\u65f6\u8bbe\u7f6e\u53c2\u6bd4\u5236\u5242\u7ec4\uff0c\u6bd4\u8f83\u4eff\u5236\u836f\u4e0e\u53c2\u6bd4\u5236\u5242\u5728\u4f53\u5185\u4e3b\u8981\u7ec4\u7ec7\u5206\u5e03\u7684\u5dee\u5f02\u3002<\/span><\/span><\/section>\n
3.\u6309\u7167\u76f8\u5173\u6307\u5bfc\u539f\u5219\u5f00\u5c55\u5236\u5242\u5b89\u5168\u6027\u8bd5\u9a8c\uff0c\u5efa\u8bae\u4e0e\u53c2\u6bd4\u5236\u5242\u6bd4\u8f83\u3002<\/span><\/span><\/section>\n
\uff08\u4e09\uff09\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76<\/span><\/strong>1,6,7,8,9<\/span><\/sup><\/strong><\/span><\/section>\n
\u7814\u7a76\u7c7b\u578b\uff1a<\/span><\/strong>\u7a7a\u8179\u8bd5\u9a8c\u3002\u5982\u679c\u75c5\u4eba\u7684\u5065\u5eb7\u72b6\u51b5\u4e0d\u5141\u8bb8\u7981\u98df\uff0c\u7533\u529e\u8005\u53ef\u5728\u7814\u7a76\u671f\u95f4\u63d0\u4f9b\u975e\u9ad8\u8102\u9910\uff0c\u6216\u53ef\u5728\u6807\u51c6\uff08\u975e\u9ad8\u8102\u9910\uff09\u65e9\u9910<\/span>2\u5c0f\u65f6\u540e\u5f00\u59cb\u6cbb\u7597\u3002<\/span><\/span><\/section>\n
\u8bd5\u9a8c<\/span><\/strong>\u8bbe\u8ba1\uff1a<\/span><\/strong>\u901a\u5e38\u91c7\u7528\u968f\u673a\u3001<\/span>\u5355\u6b21\u7ed9\u836f\u3001\u4ea4\u53c9<\/span>\u7814\u7a76<\/span>\u8bbe\u8ba1\u3002<\/span><\/span><\/section>\n
\u53d7\u8bd5\u8005\uff1a<\/span><\/strong>\u9002\u5408\u672c\u54c1\u5355\u836f\u6cbb\u7597\u7684<\/span>\u80bf\u7624\u60a3\u8005\u3002<\/span><\/span><\/section>\n
\u6ce8\u610f\u4e8b\u9879\uff1a<\/span><\/strong><\/span><\/section>\n
a. <\/span>\u5e94\u4f7f\u7528\u5546\u4e1a\u6279\u7684\u6837\u54c1\u8fdb\u884c\u5173\u952e\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u3002<\/span><\/section>\n
b. <\/span>\u8be5\u7814\u7a76\u5c06\u5728\u5b89\u6392\u60a3\u8005\u63a5\u53d7\u5e38\u89c4\u6cbb\u7597\u7684\u4e24\u5929\u5185\u8fdb\u884c\uff0c\u4e24\u4e2a\u7814\u7a76\u5468\u671f\u4e0d\u5f97\u6539\u53d8\u6216\u5ef6\u8fdf\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/section>\n
c. <\/span>\u9664\u7814\u7a76\u671f\u95f4\u60a3\u8005\u968f\u673a\u63a5\u53d7\u53d7\u8bd5\u5236\u5242\u6216\u53c2\u6bd4\u5236\u5242\u8fdb\u884c\u6cbb\u7597\u5916\uff0c\u5176\u4ed6\u65f6\u95f4\u60a3\u8005\u7684\u62a4\u7406\u6cbb\u7597\u65b9\u6848\u4e0d\u5e94\u6539\u53d8\u3002<\/span><\/section>\n
d. <\/span>\u6ce8\u5c04\u5242\u91cf\u4e3a\u6bcf4\u5468\u4e00\u6b21\uff0c\u8fde\u7eed\u4f7f\u7528\u4e24\u4e2a\u7597\u7a0b\u3002<\/span><\/section>\n
e. <\/span>\u5728\u7b49\u6548\u6027\u7814\u7a76\u7684\u4e24\u4e2a\u5468\u671f\u4e2d\uff0c\u4efb\u4f55\u5408\u5e76\u7528\u836f\u5fc5\u987b\u76f8\u540c\u3002<\/span><\/section>\n
f. <\/span>\u7531\u4e8e\u672c\u54c1\u7684\u5fc3\u810f\u6bd2\u6027\uff0c\u5e94\u5728\u57fa\u7ebf\u65f6\u8bb0\u5f55\u60a3\u8005\u7684\u5fc3\u810f\u72b6\u6001\u3002<\/span><\/section>\n
g. <\/span>\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u60a3\u8005\u7684\u4f53\u91cd\u6539\u53d8\u5bfc\u81f4\u7ed9\u836f\u5242\u91cf\u6539\u53d8\u8fbe\u5230\u00b15%\u8005\uff0c\u5fc5\u987b\u505c\u6b62\u8be5\u60a3\u8005\u7684\u7814\u7a76\uff0c\u5e76\u4e14\u8be5\u53d7\u8bd5\u8005\u7684\u6570\u636e\u4e0d\u7eb3\u5165\u6700\u7ec8BES\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u5206\u6790\u3002<\/span><\/section>\n
<\/span><\/section>\n
\u6392\u9664\u6807\u51c6\uff1a<\/span><\/strong><\/span><\/section>\n
a. <\/span>\u7ecf\u8fc74\u4e2a\u7597\u7a0b\u591a\u67d4\u6bd4\u661f\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u591a\u67d4\u6bd4\u661f\u603b\u66b4\u9732\u8fbe\u5230550mg\/m<\/span>2<\/span><\/sup>\u6216\u66f4\u591a\u3002<\/span><\/section>\n
b. <\/span>\u809d\u529f\u80fd\u660e\u663e\u53d7\u635f\u7684\u60a3\u8005\u3002<\/span><\/section>\n
c. <\/span>\u5bf9\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u5904\u65b9\u6210\u5206\u6216RLD\u5904\u65b9\u6210\u5206\u6709\u8fc7\u654f\u53f2\u7684\u60a3\u8005\u3002<\/span><\/section>\n
d. <\/span>\u598a\u5a20\u671f\u548c\u54fa\u4e73\u671f\u7684\u5973\u6027\u60a3\u8005\u3002<\/span><\/section>\n
e. <\/span>\u5e74\u9f84\u5c0f\u4e8e18\u5c81\u6216\u5927\u4e8e75\u5468\u5c81\u7684\u60a3\u8005\u3002<\/span><\/section>\n
f. <\/span>\u5904\u4e8e\u9aa8\u9ad3\u6bd2\u6027\u836f\u7269\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u5206\u679d\u6746\u83cc\u3001\u5de8\u7ec6\u80de\u75c5\u6bd2\u3001\u5f13\u5f62\u866b\u3001\u5361\u6c0f\u80ba\u5b62\u5b50\u866b\u6216\u5176\u4ed6\u5fae\u751f\u7269\u7684\u673a\u4f1a\u6027\u611f\u67d3\u8005\u3002<\/span><\/section>\n
g. <\/span>\u6709\u4e25\u91cd\u7684\u5fc3\u810f\u3001\u809d\u810f\u6216\u80be\u810f\u75be\u75c5\u7684\u60a3\u8005\u3002<\/span><\/section>\n
<\/span><\/section>\n
\u68c0\u6d4b\u7269\u8d28\uff1a<\/span><\/strong>\u5728\u9002\u5f53\u7684\u751f\u7269\u4f53\u6db2\u4e2d\u6e38\u79bb\u7684\uff08\u975e\u5305\u5c01\u7684\uff09\u591a\u67d4\u6bd4\u661f\u548c\u8102\u8d28\u4f53\u5305\u5c01\u7684\u591a\u67d4\u6bd4\u661f\u3002<\/span><\/span><\/section>\n
\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u6307\u6807\uff1a<\/span><\/strong>\u5e94\u63d0\u4f9b\u5305\u62ec\u53d7\u8bd5\u5236\u5242\u548c\u53c2\u6bd4\u5236\u5242<\/span>\u6e38\u79bb\u7684\u548c\u8102\u8d28\u4f53\u5305\u5c01\u7684\u591a\u67d4\u6bd4\u661f<\/span>\u7684<\/span>AUC<\/span>0-t<\/span><\/sub>\u3001<\/span>AUC<\/span>0-\u221e<\/span><\/sub>\u3001<\/span>C<\/span>max<\/span><\/sub>\u51e0\u4f55\u5747\u503c\u3001\u51e0\u4f55\u5747\u503c\u6bd4\u503c\u53ca\u5176<\/span>90%\u7f6e\u4fe1\u533a\u95f4\u3002<\/span><\/span>\u540c\u65f6\u589e\u52a0<\/span>\u8102\u8d28\u4f53<\/span>\u5305\u5c01\u7684\u591a\u67d4\u6bd4\u661f\u7684\u90e8\u5206\u66b4\u9732\u91cf\u6307\u6807\uff08\u5982<\/span>AUC<\/span>0-48h<\/span><\/sub>\u548c<\/span>AUC<\/span>48h-last<\/span><\/sub>\uff09\u4ee5\u8003\u5bdf\u4e0d\u540c\u65f6\u95f4\u6bb5\u7684\u66b4\u9732\u91cf\u3002<\/span><\/span><\/section>\n
\u751f\u7269\u7b49\u6548<\/span><\/strong>\u7684\u63a5\u53d7\u6807\u51c6<\/span><\/strong>\uff08<\/span>90% CI\uff09<\/span><\/strong>\uff1a\u6e38\u79bb\u7684\u548c\u8102\u8d28\u4f53\u5305\u5c01\u7684\u591a\u67d4\u6bd4\u661f\u7684<\/span>AUC<\/span>0-t<\/span><\/sub>\u3001<\/span>AUC<\/span>0-\u221e<\/span><\/span><\/sub>\u3001<\/span>C<\/span>max<\/span><\/sub>\uff0c\u4ee5\u53ca<\/span>\u8102\u8d28\u4f53<\/span>\u5305\u5c01\u7684\u591a\u67d4\u6bd4\u661f\u7684\u90e8\u5206\u66b4\u9732\u91cf\u6307\u6807\uff08\u5982<\/span>AUC<\/span>0-48h<\/span><\/sub>\u548c<\/span>AUC<\/span>48h-last<\/span><\/sub>\uff09\uff0c<\/span>\u5176\u51e0\u4f55\u5747\u503c\u6bd4\u503c\u7684<\/span>90%\u7f6e\u4fe1\u533a\u95f4\u6570\u503c\u5e94\u4e0d\u4f4e\u4e8e<\/span>80.00%<\/span>\uff0c\u4e14\u4e0d\u8d85\u8fc7<\/span>125.00%<\/span>\u3002<\/span><\/span><\/span><\/section>\n
\u5176\u4ed6\uff1a<\/span><\/strong>\u6ce8\u518c\u7533\u62a5\u65f6\uff0c\u9664\u4e86\u4e0a\u8ff0\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u4e4b\u5916\uff0c\u8fd8\u9700\u63d0\u4f9b\u5176\u4ed6\u5168\u9762\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u7684\u4e2a\u4f53\u548c\u5e73\u5747\u503c\uff0c\u5982\u8fbe\u5cf0\u65f6\u95f4\u3001\u6d88\u9664\u534a\u8870\u671f\u3001\u6e05\u9664\u7387\u3001\u8868\u89c2\u5206\u5e03\u5bb9\u79ef\u7b49\u3002<\/span><\/span><\/section>\n
\u56db\u3001\u53c2\u8003<\/span><\/strong>\u6587\u732e<\/span><\/strong><\/span><\/section>\n
1.<\/span>\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3<\/span>. \u300a\u5316\u5b66\u836f\u54c1\u6ce8\u5c04\u5242\u4eff\u5236\u836f\uff08\u7279\u6b8a\u6ce8\u5c04\u5242\uff09\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u6280\u672f\u8981\u6c42\u300b\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09\uff082019\u5e74<\/span>11\u6708\uff09<\/span><\/span><\/span><\/section>\n
2.<\/span>\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40<\/span>. \u300a\u5316\u5b66\u836f\u54c1\u6ce8\u5c04\u5242\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u6280\u672f\u8981\u6c42\u300b\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09\uff08<\/span>2019\u5e74<\/span>9\u6708\uff09<\/span><\/span><\/span><\/section>\n
3.<\/span>\u300a\u56fd\u5bb6\u836f\u76d1\u5c40\u5173\u4e8e\u8fdb\u4e00\u6b65\u5b8c\u5584\u836f\u54c1\u5173\u8054\u5ba1\u8bc4\u5ba1\u6279\u548c\u76d1\u7ba1\u5de5\u4f5c\u6709\u5173\u4e8b\u5b9c\u7684\u516c\u544a\u300b\uff08<\/span>2019\u5e74\u7b2c56\u53f7\uff09<\/span><\/span><\/section>\n
4.A. Gabizon, H. Sheemda, Y. Barenholz. Pharmacokinetics of pegylated liposome doxorubicin: review of animal and human studies. Clin Pharmcokinet 42(5): 419-436 (2003)<\/span><\/section>\n
5.<\/span>\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3<\/span>. \u300a\u5316\u5b66\u4eff\u5236\u836f\u6ce8\u518c\u6279\u751f\u4ea7\u89c4\u6a21\u7684\u4e00\u822c\u6027\u8981\u6c42\uff08\u8bd5\u884c\uff09\u300b\uff08<\/span>2018\u5e746\u6708\uff09<\/span><\/span><\/section>\n
6.<\/span> \uff08\u539f\uff09\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40<\/span>. \u300a\u4ee5\u836f\u52a8\u5b66\u53c2\u6570\u4e3a\u7ec8\u70b9\u8bc4\u4ef7\u6307\u6807\u7684\u5316\u5b66\u836f\u7269\u4eff\u5236\u836f\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff082016\u5e74\u7b2c61\u53f7\u901a\u544a\uff09<\/span><\/span><\/section>\n
7.<\/span> \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3<\/span>. \u300a\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u7edf\u8ba1\u5b66\u6307\u5bfc\u539f\u5219\u300b\uff08<\/span>2018\u5e7410\u6708\uff09<\/span><\/span><\/span><\/section>\n
8.<\/span> <\/span>Food and Drug Administration. Draft Guidance on Doxorubicin Hydrochloride. Recommended Feb 2010; Revised Nov 2013, Dec 2014, Apr 2017, Sept 2018<\/span><\/span><\/section>\n
9. European Medicines Agency. Pegylated liposomal doxorubicin hydrochloride concentrate for solution 2 mg\/ml product-specific bioequivalence guidance. 1 July 2019, EMA\/CHMP\/800775\/2017<\/span><\/section>\n
\u6765\u6e90\uff1aCDE\uff0c<\/strong><\/span>\u9644\u4ef62-3\u7565<\/strong><\/section>\n

\"CDE\u53d1\u5e03\u300a\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4eff\u5236\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u5f81\u6c42\u610f\u89c1\uff0c\u8d28\u91cf\u5bf9\u6bd4>BE>\u6216\u4e34\u5e8a\"<\/p>\n

\"CDE\u53d1\u5e03\u300a\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4eff\u5236\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u5f81\u6c42\u610f\u89c1\uff0c\u8d28\u91cf\u5bf9\u6bd4>BE>\u6216\u4e34\u5e8a\"<\/section>\n
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\"CDE\u53d1\u5e03\u300a\u76d0\u9178\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6ce8\u5c04\u6db2\u4eff\u5236\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u5f81\u6c42\u610f\u89c1\uff0c\u8d28\u91cf\u5bf9\u6bd4>BE>\u6216\u4e34\u5e8a\"<\/p>\n

\u836f\u878d\u5708\u81f4\u529b\u4e8e\u6253\u9020\u533b\u836f\u884c\u4e1a\u751f\u6001\u5708\uff0c\u5171\u5efa\u3001\u5171\u521b\u3001\u5171\u8d62\u3001\u5171\u4eab\uff0c\u65e8\u5728\u89e3\u51b3\u751f\u7269\u533b\u836f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u5171\u6027\u5173\u952e\u95ee\u9898(\u9879\u76ee\u3001\u8d44\u672c\u3001\u4eba\u624d\u7b49)\uff0c\u5c06\u5e73\u53f0\u7684\u534f\u540c\u3001\u8054\u52a8\u3001\u5171\u4eab\u3001\u5171\u8d62\u4f18\u52bf\u6700\u5927\u5316\u5b9e\u73b0\u5e76\u53d1\u6325\uff0c\u60e0\u53ca\u5343\u4e07\u4f01\u4e1a\u3002\u5bf9\u5927\u4f01\u4e1a\u5b9e\u73b0\u52a0\u901f\u8d4b\u80fd\uff0c\u5bf9\u4e2d\u5c0f\u4f01\u4e1a\u5b9e\u73b0\u52a9\u529b\u5b75\u5316\uff0c\u5f62\u6210\u4f01\u4e1a\u670d\u52a1\u9886\u57df\u65b0\u751f\u6001\u3002\u836f\u878d\u5708\u56f4\u7ed5\u6211\u56fd\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u94fe\uff0c\u9488\u5bf9\u751f\u7269\u533b\u836f\u5927\u6570\u636e\u3001\u6280\u672f\u548c\u8d44\u672c\u6295\u8d44\u3001\u836f\u878d\u56ed(\u4ea7\u4e1a\u56ed)\u7b49\u5f00\u5c55\u7cfb\u5217\u7cfb\u7edf\u6027\u5de5\u4f5c\uff0c\u4fc3\u8fdb\u6211\u56fd\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u5065\u5eb7\u53d1\u5c55\uff0c\u5b8c\u5584\u4ea7\u4e1a\u94fe\uff0c\u5171\u540c\u9762\u5bf9\u5168\u7403\u5408\u4f5c\u548c\u7ade\u4e89\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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