{"id":122659,"date":"2020-03-19T06:27:38","date_gmt":"2020-04-21T01:03:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/122659\/"},"modified":"2020-04-21T09:03:16","modified_gmt":"2020-04-21T01:03:16","slug":"940a4e37ac","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/122659\/","title":{"rendered":"\u6700\u65b0\uff01\u4e1c\u4eac\u5927\u5b66\uff1a\u8418\u83ab\u53f8\u4ed6\u5728\u6d53\u5ea6\u4f4e\u81f31-10 nM\u65f6\u80fd\u660e\u663e\u963b\u6b62\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u4fb5\u5165\u4eba\u4f53\u200b"},"content":{"rendered":"
\n

\"\u6700\u65b0\uff01\u4e1c\u4eac\u5927\u5b66\uff1a\u8418\u83ab\u53f8\u4ed6\u5728\u6d53\u5ea6\u4f4e\u81f31-10<\/p>\n

\u8fd1\u671f\uff0c\u4e1c\u4eac\u5927\u5b66\u533b\u5b66\u79d1\u5b66\u7814\u7a76\u6240\u4e9a\u6d32\u4f20\u67d3\u75c5\u7814\u7a76\u4e2d\u5fc3\u7684\u4e95\u4e0a\u6df3\u4e00\u90ce\u53ca\u5176\u56e2\u961f\u4e0e3\u670818\u65e5\u4e0b\u5348\u5bf9\u5916\u516c\u5e03\uff0c\u539f\u7528\u4f5c\u6cbb\u7597\u80f0\u817a\u708e\u7684\u836f\u54c1\u8418\u83ab\u53f8\u4ed6\uff08Nafamostat\uff09\u5728\u6d53\u5ea6\u4f4e\u81f31-10 nM\u65f6\u80fd\u660e\u663e\u963b\u6b62\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u4fb5\u5165\u4eba\u4f53\u3002
<\/span><\/p>\n

\u8418\u83ab\u53f8\u4ed6\u901a\u8fc7\u9632\u6b62\u75c5\u6bd2\u5916\u819c\uff08\u88ab\u75c5\u6bd2SARS-CoV-2\u611f\u67d3\u7684\u7b2c\u4e00\u9636\u6bb5\uff09\u4e0e\u88ab\u611f\u67d3\u7ec6\u80de\u7684\u7ec6\u80de\u819c\u878d\u5408\uff0c\u4ece\u800c\u5bf9\u65b0\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff08COVID-19\uff09\u7684\u5165\u4fb5\u8fc7\u7a0b\u8fdb\u884c\u963b\u65ad\u3002<\/span><\/p>\n

\u4eca\u5e743\u6708\u521d\uff0c\u5fb7\u56fd\u5c0f\u7ec4\u5ba3\u5e03\u4e86Camostat\uff08\u5361\u83ab\u53f8\u4ed6\u7532\u78fa\u9178\u916f\uff0c\u5546\u54c1\u540dFoypan\uff09\u8fd9\u4e00\u79cd\u4e0e\u8418\u83ab\u53f8\u4ed6\u7c7b\u4f3c\u7684\u836f\u7269\u5bf9SARS-CoV-2\u6709\u4e00\u5b9a\u7597\u6548\u3002\u8418\u83ab\u53f8\u4ed6\u5219\u4ee5\u4f4e\u81f3\u5341\u5206\u4e4b\u4e00\u6216\u66f4\u4f4e\u7684\u6d53\u5ea6\u963b\u6b62\u4e86\u75c5\u6bd2\u8fdb\u5165\u8fc7\u7a0b\u3002<\/span><\/p>\n

\u8418\u83ab\u53f8\u4ed6Nafamostat\u548c\u5361\u83ab\u53f8\u4ed6Camostat\u90fd\u662f\u5728\u65e5\u672c\u5f00\u53d1\u7684\uff0c\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u80f0\u817a\u708e\uff0c\u5e76\u4e14\u5728\u65e5\u672c\u5df2\u5f00\u5904\u65b9\u591a\u5e74\u3002\u4e3a\u4e86\u5b89\u5168\u8d77\u89c1\uff0c\u5df2\u7ecf\u79ef\u7d2f\u4e86\u8db3\u591f\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u53ef\u4ee5\u8fc5\u901f\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

\"\u6700\u65b0\uff01\u4e1c\u4eac\u5927\u5b66\uff1a\u8418\u83ab\u53f8\u4ed6\u5728\u6d53\u5ea6\u4f4e\u81f31-10<\/p>\n

Nafamostat\uff0c\u4f5c\u4e3a\u4e1d\u6c28\u9178\u86cb\u767d\u9176\u6291\u5236\u5242\uff0c\u88ab\u53d1\u73b0\u6291\u5236\u819c\u878d\u5408\u7684\u6d53\u5ea6\u5c0f\u4e8e\u5df2\u516c\u5f00\u7684\u878d\u5408\u6291\u5236\u5242\u7684\u5341\u5206\u4e4b\u4e00\u3002<\/span><\/p>\n

SARS-CoV-2\u611f\u67d3\u4eba\u4f53\uff0c\u9700\u8981\u4e0e\u7ec6\u80de\u8868\u9762\u4e0a\u5b58\u5728\u7684\u53d7\u4f53\u86cb\u767d\uff08ACE2\u53d7\u4f53\uff09\u7ed3\u5408\u540e\uff0c\u75c5\u6bd2\u5916\u819c\u4e0e\u7ec6\u80de\u819c\u53d1\u751f\u878d\u5408\u3002\u5c31\u51a0\u72b6\u75c5\u6bd2\u800c\u8a00\uff0cSpike\u86cb\u767d\uff08S\u86cb\u767d\uff09\u4e0e\u4eba\u7ec6\u80de\u7ec6\u80de\u819c\u4e0a\u7684ACE2\u53d7\u4f53\u7ed3\u5408\uff0c\u7136\u540e\u88ab\u86cb\u767d\u6c34\u89e3\u9176TMPRSS2\u88c2\u89e3\uff0c\u4ece\u800c\u6fc0\u6d3bS\u86cb\u767d\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5bf9\u4e8e\u878d\u5408\u5f88\u91cd\u8981\u3002<\/span><\/p>\n

Inoue\u7b49\u4eba\u6839\u636eMERS\u51a0\u72b6\u75c5\u6bd2\u7684\u7814\u7a76\u7ed3\u679c\u68c0\u9a8c\u4e86Nafamostat\u548cCamostat\u7684\u4f5c\u7528\u3002\u8fd9\u8868\u660eNafamostat\u6709\u6f5c\u529b\u975e\u5e38\u6709\u6548\u5730\u6291\u5236SARS-CoV-2\u611f\u67d3\u3002<\/span><\/p>\n

\u8418\u83ab\u53f8\u4ed6\uff08Nafamostat\uff09<\/span>\u5728\u6d53\u5ea6\u4f4e\u81f31-10 nM\u65f6\u80fd\u660e\u663e\u963b\u6b62\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u4fb5\u5165<\/span>\u4eba\u4f53<\/span><\/span><\/p>\n

\u5176\u4ed6\u6709\u6548\/\u6f5c\u5728\u6709\u6548\u836f\u4fe1\u606f\uff1a<\/span><\/section>\n
\n
\u56fd\u52a1\u9662\u8054\u9632\u8054\u63a7\u673a\u5236\u4e8e3\u670817\u65e515\u65f6\u5728\u5317\u4eac\u56fd\u4e8c\u62db\u5bbe\u9986\uff08\u5317\u4eac\u5e02\u897f\u76f4\u95e8\u5357\u5927\u88576\u53f7\uff09\u4e1c\u697c\u4e09\u5c42\u4e2d\u4f1a\u8bae\u5385\u53ec\u5f00\u65b0\u95fb\u53d1\u5e03\u4f1a\uff0c\u4ecb\u7ecd\u836f\u7269\u75ab\u82d7\u548c\u68c0\u6d4b\u8bd5\u5242\u7814\u53d1\u653b\u5173\u6700\u65b0\u60c5\u51b5\u3002<\/span><\/section>\n
\n
\u79d1\u6280\u90e8\u751f\u7269\u4e2d\u5fc3\u4e3b\u4efb\u5f20\u65b0\u6c11\u5728\u56de\u590d\u65b0\u534e\u793e\u8bb0\u8005\uff0c\u5173\u4e8e\u836f\u7269\u7814\u53d1\u7684\u6700\u65b0\u8fdb\u5c55\u6709\u54ea\u4e9b\u7684\u95ee\u9898\u4e0a\u3002\u56de\u7b54\u9053\uff1a<\/span><\/section>\n
\u6309\u7167\u4e60\u8fd1\u5e73\u603b\u4e66\u8bb03\u67082\u65e5\u5728\u5317\u4eac\u8003\u5bdf\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u9632\u63a7\u79d1\u7814\u653b\u5173\u5de5\u4f5c\u65f6\u7684\u91cd\u8981\u6307\u793a\u8981\u6c42\uff0c\u79d1\u7814\u653b\u5173\u7ec4\u8fdb\u4e00\u6b65\u5f3a\u5316\u5bf9\u4e00\u7ebf\u4e34\u5e8a\u6551\u6cbb\u7684\u652f\u6491\u548c\u670d\u52a1\u3002\u9488\u5bf9\u8f7b\u578b\u3001\u666e\u901a\u578b\u5411\u91cd\u578b\u8f6c\u5316\u7684\u963b\u65ad\uff0c\u91cd\u70b9\u63a8\u52a8\u78f7\u9178\u6c2f\u55b9\u3001\u6cd5\u5339\u62c9\u97e6\u548c\u4e2d\u533b\u836f\uff0c\u9488\u5bf9\u91cd\u578b\u3001\u5371\u91cd\u578b\u60a3\u8005\u7684\u6551\u6cbb\uff0c\u91cd\u70b9\u63a8\u52a8\u6062\u590d\u671f\u8840\u6d46\u3001\u6258\u73e0\u5355\u6297\u3001\u548c\u4eba\u5de5\u809d\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u76ee\u524d\u5747\u5df2\u53d6\u5f97\u826f\u597d\u7684\u8fdb\u5c55\u3002\u5176\u4e2d\u6cd5\u5339\u62c9\u97e6\u5df2\u5b8c\u6210\u4e34\u5e8a\u7814\u7a76\uff0c\u663e\u793a\u51fa\u5f88\u597d\u7684\u4e34\u5e8a\u7597\u6548\u3002\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u6cd5\u5339\u62c9\u97e6\u5df2\u7ecf\u4e8e2014\u5e74\u5728\u65e5\u672c\u83b7\u6279\u4e0a\u5e02\uff0c\u4e0a\u5e02\u4ee5\u6765\u672a\u89c1\u660e\u663e\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u672a\u53d1\u73b0\u660e\u663e\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/section>\n
\u5728\u6709\u6548\u6027\u65b9\u9762\uff0c\u6df1\u5733\u5e02\u7b2c\u4e09\u4eba\u6c11\u533b\u9662\u5f00\u5c55\u7684\u6cd5\u5339\u62c9\u97e6\u8054\u5408\u5e72\u6270\u7d20<\/span>\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7814\u7a76\uff0c\u5165\u7ec4\u60a3\u800580\u4f8b\uff0c\u5176\u4e2d\u6cd5\u5339\u62c9\u97e6\u7ec435\u4f8b\uff0c\u5bf9\u7167\u7ec445\u4f8b\u3002<\/span>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u75c5\u6bd2\u6838\u9178\u8f6c\u9634\u65b9\u9762\uff0c\u6cd5\u5339\u62c9\u97e6\u6cbb\u7597\u7ec4\u6cbb\u7597\u540e\u60a3\u8005\u75c5\u6bd2\u6838\u9178\u8f6c\u9634\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u8f6c\u9634\u65f6\u95f4\u4e2d\u4f4d\u503c\u660e\u663e\u7f29\u77ed\uff0c\u5206\u522b\u4e3a4\u5929\u548c11\u5929\uff0c\u5177\u6709\u663e\u8457\u5dee\u5f02\u3002<\/span>\u5728\u80f8\u90e8\u5f71\u50cf\u5b66\u6539\u5584\u65b9\u9762\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6539\u5584\u7387\u5206\u522b\u4e3a91.43%\u548c62.22%\u3002<\/span><\/section>\n
\u6b66\u6c49\u5927\u5b66\u4e2d\u5357\u533b\u9662\u7275\u5934\u5f00\u5c55\u4e86\u6cd5\u5339\u62c9\u97e6\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u3001\u9633\u6027\u5e73\u884c\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff0c\u5df2\u5b8c\u6210\u5404120\u4f8b\u5165\u7ec4\u548c\u4e34\u5e8a\u6cbb\u7597\u89c2\u5bdf\u3002<\/span>\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u8bd5\u9a8c\u7ec4\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u7597\u6548\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\u7ec4\u3002<\/span>\u5728\u4e3b\u8981\u7ec8\u70b9\u8bc4\u4ef7\u6307\u6807\u65b9\u9762\uff0c\u666e\u901a\u578b\u60a3\u8005\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\u7684\u4e34\u5e8a\u6062\u590d\u7387\uff0c\u8bd5\u9a8c\u7ec4\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5206\u522b\u4e3a71.43%\u548c55.86%\u3002<\/span>\u5728<\/span>\u6b21\u8981\u7ec8<\/span>\u70b9\u8bc4\u4ef7\u6307\u6807\u65b9\u9762\uff0c\u8bd5\u9a8c\u7ec4\u5728\u9000\u70ed\u65f6\u95f4\u4e0a\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5e73\u5747\u9000\u70ed\u65f6\u95f4\u5206\u522b\u4e3a2.5\u5929\u548c4.2\u5929\u3002<\/span>\u8bd5\u9a8c\u7ec4\u5728\u54b3\u55fd\u7f13\u89e3\u65f6\u95f4\u4e0a\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5e73\u5747\u54b3\u55fd\u7f13\u89e3\u65f6\u95f4\u5206\u522b\u4e3a4.57\u5929\u548c5.98\u5929\uff0c\u666e\u901a\u578b\u60a3\u8005\u5728\u6cbb\u7597\u671f\u95f4\u7684\u8f85\u52a9\u6c27\u7597\u6216\u65e0\u521b\u673a\u68b0\u901a\u6c14\u7387\uff0c\u8bd5\u9a8c\u7ec4\u663e\u8457\u4f4e\u4e8e\u5bf9\u7167\u7ec4\uff0c\u5206\u522b\u4e3a8.16%\u548c17.12%\u3002<\/span>\u4ee5\u4e0a\u8bc4\u4ef7\u6307\u6807\uff0c\u4e24\u7ec4\u95f4\u5747\u5177\u6709\u7edf\u8ba1\u5b66\u7684\u5dee\u5f02\u3002<\/span><\/section>\n
\u5728\u53ef\u53ca\u6027\u65b9\u9762\uff0c\u4eca\u5e742\u6708\u56fd\u5185\u5df2\u6709\u4f01\u4e1a\u83b7\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\uff0c\u5e76\u5b9e\u73b0\u91cf\u4ea7\uff0c\u4e34\u5e8a\u836f\u54c1\u4f9b\u5e94\u6709\u4fdd\u969c\u3002<\/span><\/section>\n
\u9274\u4e8e\u6cd5\u5339\u62c9\u97e6\u5b89\u5168\u6027\u597d\u3001\u7597\u6548\u660e\u786e\u3001\u836f\u54c1\u53ef\u53ca\uff0c\u7ecf\u8fc7\u79d1\u7814\u653b\u5173\u7ec4\u7ec4\u7ec7\u4e13\u5bb6\u5145\u5206\u8bba\u8bc1\uff0c\u5df2\u6b63\u5f0f\u5411\u533b<\/span>\u7597\u6551\u6cbb\u7ec4\u63a8<\/span>\u8350\uff0c\u5efa\u8bae\u5c3d\u5feb\u7eb3\u5165\u8bca\u7597\u65b9\u6848\u3002<\/span><\/section>\n
\u53c2\u8003\u8d44\u6599\u6765\u6e90<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n
https:\/\/www.u-tokyo.ac.jp\/content\/400133690.pdf<\/span>
<\/section>\n
\u4e2d\u56fd\u836f\u95fb<\/span><\/section>\n
\"\u6700\u65b0\uff01\u4e1c\u4eac\u5927\u5b66\uff1a\u8418\u83ab\u53f8\u4ed6\u5728\u6d53\u5ea6\u4f4e\u81f31-10<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\"\u6700\u65b0\uff01\u4e1c\u4eac\u5927\u5b66\uff1a\u8418\u83ab\u53f8\u4ed6\u5728\u6d53\u5ea6\u4f4e\u81f31-10<\/p>\n

\u836f\u878d\u5708\u81f4\u529b\u4e8e\u6253\u9020\u533b\u836f\u884c\u4e1a\u751f\u6001\u5708\uff0c\u5171\u5efa\u3001\u5171\u521b\u3001\u5171\u8d62\u3001\u5171\u4eab\uff0c\u65e8\u5728\u89e3\u51b3\u751f\u7269\u533b\u836f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u5171\u6027\u5173\u952e\u95ee\u9898(\u9879\u76ee\u3001\u8d44\u672c\u3001\u4eba\u624d\u7b49)\uff0c\u5c06\u5e73\u53f0\u7684\u534f\u540c\u3001\u8054\u52a8\u3001\u5171\u4eab\u3001\u5171\u8d62\u4f18\u52bf\u6700\u5927\u5316\u5b9e\u73b0\u5e76\u53d1\u6325\uff0c\u60e0\u53ca\u5343\u4e07\u4f01\u4e1a\u3002\u5bf9\u5927\u4f01\u4e1a\u5b9e\u73b0\u52a0\u901f\u8d4b\u80fd\uff0c\u5bf9\u4e2d\u5c0f\u4f01\u4e1a\u5b9e\u73b0\u52a9\u529b\u5b75\u5316\uff0c\u5f62\u6210\u4f01\u4e1a\u670d\u52a1\u9886\u57df\u65b0\u751f\u6001\u3002\u836f\u878d\u5708\u56f4\u7ed5\u6211\u56fd\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u94fe\uff0c\u9488\u5bf9\u751f\u7269\u533b\u836f\u5927\u6570\u636e\u3001\u6280\u672f\u548c\u8d44\u672c\u6295\u8d44\u3001\u836f\u878d\u56ed(\u4ea7\u4e1a\u56ed)\u7b49\u5f00\u5c55\u7cfb\u5217\u7cfb\u7edf\u6027\u5de5\u4f5c\uff0c\u4fc3\u8fdb\u6211\u56fd\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u5065\u5eb7\u53d1\u5c55\uff0c\u5b8c\u5584\u4ea7\u4e1a\u94fe\uff0c\u5171\u540c\u9762\u5bf9\u5168\u7403\u5408\u4f5c\u548c\u7ade\u4e89\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u671f\uff0c\u4e1c\u4eac\u5927\u5b66\u533b\u5b66\u79d1\u5b66\u7814\u7a76\u6240\u4e9a\u6d32\u4f20\u67d3\u75c5\u7814\u7a76\u4e2d\u5fc3\u7684\u4e95\u4e0a\u6df3\u4e00\u90ce\u53ca\u5176\u56e2\u961f\u4e0e3\u670818\u65e5\u4e0b\u5348\u5bf9\u5916\u516c\u5e03\uff0c\u539f\u7528\u4f5c\u6cbb\u7597\u80f0\u817a\u708e\u7684 […]<\/p>\n","protected":false},"author":1,"featured_media":122660,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/122659"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=122659"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/122659\/revisions"}],"predecessor-version":[{"id":122665,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/122659\/revisions\/122665"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/122660"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=122659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=122659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=122659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}