{"id":124651,"date":"2019-09-03T11:55:50","date_gmt":"2020-04-21T02:01:14","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/124651\/"},"modified":"2020-04-21T10:01:14","modified_gmt":"2020-04-21T02:01:14","slug":"11ef494279","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/124651\/","title":{"rendered":"\u751f\u7269\u7c7b\u4f3c\u836f IBI303 \u6cbb\u7597\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684 III \u671f\u4e34\u5e8a\u7814\u7a76\u767b\u4e0a\u300a\u67f3\u53f6\u5200\u00b7\u98ce\u6e7f\u75c5\u5b66\u300b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<section  label=\"Powered by 135editor.com\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"line-height: 1.5;padding-right: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(95, 156, 239);width: 100%;padding: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"display: inline-block;vertical-align: top;width: 35%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"display: inline-block;vertical-align: top;width: 55%;background-color: rgb(160, 160, 160);box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" >\n<section style=\"text-align: justify;color: rgb(255, 255, 255);font-size: 46px;line-height: 1.5;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6982<br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 45%;box-sizing: border-box;\">\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-ms-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);\" >\n<section style=\"text-align: justify;color: rgb(255, 255, 255);line-height: 1.2;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 36px;box-sizing: border-box;\">\u89c8<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 65%;box-sizing: border-box;\">\n<section style=\"text-align: right;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-ms-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);\" >\n<section style=\"text-align: justify;color: rgb(255, 255, 255);font-size: 14px;padding-right: 5px;padding-left: 5px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 15px;letter-spacing: 0px;caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">\u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u516c\u5f00\u53d1\u8868\u7684\u5173\u4e8e\u751f\u7269\u7c7b\u4f3c\u836f\u548c\u539f\u7814\u836f\u5728\u6d3b\u52a8\u6027 AS \u60a3\u8005\u4e2d\u7684\u5927\u578b\u5934\u5bf9\u5934\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e5f\u662f\u4e2d\u56fd\u4f01\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u4e0a\u5e02\u7814\u7a76\u9996\u6b21\u767b\u4e0a\u56fd\u9645\u77e5\u540d\u533b\u5b66\u6742\u5fd7<\/span><span class=\"Apple-converted-space\" style=\"font-size: 15px;letter-spacing: 0px;caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">&nbsp;<\/span><sup style=\"letter-spacing: 0px;caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">1,2<\/sup><span style=\"font-size: 15px;letter-spacing: 0px;caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">\u3002<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"border-bottom: 1px solid rgb(152, 152, 152);box-sizing: border-box;\"><\/section>\n<section style=\"width: 0px;margin: auto;border-top: 9px solid rgb(152, 152, 152);border-left: 9px solid transparent !important;border-right: 9px solid transparent !important;box-sizing: border-box;\"><\/section>\n<section style=\"width: 0px;margin-top: -10px;margin-right: auto;margin-left: auto;border-top: 9px solid rgb(255, 255, 255);box-sizing: border-box;border-left: 9px solid transparent !important;border-right: 9px solid transparent !important;\"><\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-bottom: 10px;margin-left: 0%;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(243, 243, 243);padding-top: 10px;padding-bottom: 10px;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"color: rgba(62, 62, 62, 0.95);padding-right: 25px;padding-left: 25px;font-size: 15px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;color: rgb(51, 51, 51);caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">2019 \u5e74 8 \u6708 28 \u65e5\uff0c\u7531\u6e05\u534e\u5927\u5b66\u533b\u5b66\u9662\u5f90\u6caa\u6d4e\u6559\u6388\u7275\u5934\u7684\u56fd\u4ea7\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u4fe1\u8fbe\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u91cd\u7ec4\u4eba\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\u5355\u6297 IBI303 \u4e0e\u539f\u7814\u836f\u7269\u963f\u8fbe\u6728\u5355\u6297\u5728\u6d3b\u52a8\u6027\u5f3a\u76f4\u6027\u810a\u67f1\u708e\uff08AS\uff09\u60a3\u8005\u4e2d\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5e73\u884c\u5bf9\u7167\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u53d1\u8868\u4e8e\u5728\u56fd\u9645\u77e5\u540d\u671f\u520a\u300a\u67f3\u53f6\u5200\u00b7\u98ce\u6e7f\u75c5\u5b66\u300b\uff0c\u5e76\u83b7\u5f97\u6742\u5fd7\u5c01\u9762\u63a8\u8350<\/span><span class=\"Apple-converted-space\" style=\"letter-spacing: 0px;color: rgb(51, 51, 51);caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">&nbsp;<\/span><sup style=\"letter-spacing: 0px;color: rgb(51, 51, 51);caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">1,2<\/sup><span style=\"letter-spacing: 0px;color: rgb(51, 51, 51);caret-color: rgb(51, 51, 51);box-sizing: border-box;font-family: Avenir, sans-serif;\">\u3002\u540c\u65f6\uff0c\u56fd\u9645\u9876\u7ea7\u98ce\u6e7f\u75c5\u5b66\u6559\u6388\u5fb7\u514b\u8428\u65af\u897f\u5357\u533b\u5b66\u4e2d\u5fc3 Stanley Cohen \u6559\u6388\u64b0\u5199\u8bc4\u8ff0\u9686\u91cd\u63a8\u8350\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><br  \/><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u8be5\u7814\u7a76\u663e\u793a\uff1a<\/span><span style=\"color: rgba(62, 62, 62, 0.95);letter-spacing: 0px;box-sizing: border-box;font-family: Helvetica, Arial, sans-serif;\">\u56fd\u4ea7\u751f\u7269\u7c7b\u4f3c\u836fIBI303\u4e0e\u8fdb\u53e3\u539f\u7814TNF-\u03b1 \u963f\u8fbe\u6728\u5355\u6297\u7597\u6548\u548c\u5b89\u5168\u6027\u76f8\u5f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: left;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;box-sizing: border-box;\">\n<section style=\"background-color: rgb(70, 85, 152);width: 1.6em;height: 1.6em;text-align: center;font-size: 18px;line-height: 1.6em;color: rgb(255, 255, 255);box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\">\n<section style=\"box-sizing: border-box;\">01<\/section>\n<\/section>\n<section style=\"width: 0px;margin-left: auto;border-width: 3px;border-style: solid;border-color: rgb(70, 85, 152) transparent transparent rgb(70, 85, 152);box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\"><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;margin-left: -6px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;height: 1.6em;line-height: 1.7em;background-color: rgb(240, 240, 240);text-align: center;padding-left: 10px;padding-right: 4px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"caret-color: rgb(51, 51, 51);text-align: justify;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u5f3a\u76f4\u6027\u810a\u67f1\u708e\uff1a\u4e0d\u6b7b\u7684\u764c\u75c7<\/span><\/strong><\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 0px;border-left: 0.8em solid rgb(240, 240, 240);border-top: 0.8em solid transparent !important;border-bottom: 0.8em solid transparent !important;box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"text-align: center;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"display: inline-block;width: 97%;vertical-align: top;padding: 15px;border-width: 0px;border-radius: 10px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;box-shadow: rgb(70, 85, 152) 0px 0px 6px;box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 15px;box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u4e00\u672c\u94a2\u94c1\u662f\u600e\u6837\u70bc\u6210\u7684\u8ba9\u5168\u4e16\u754c\u88ab\u5965\u65af\u7279\u6d1b\u592b\u65af\u57fa\u6253\u52a8\uff0c\u4e00\u66f2\u9752\u82b1\u74f7\u8ba9\u5927\u8857\u5c0f\u5df7\u8bb0\u4f4f\u4e86\u5468\u6770\u4f26\uff0c\u4e00\u90e8\u8717\u5c45\u8ba9\u7ea2\u5c18\u7537\u5973\u77e5\u9053\u4e86\u5f20\u5609\u8bd1\uff0c\u4e00\u53e5\u81e3\u59be\u4e0d\u80fd\u554a\u8ba9\u8001\u8001\u5c11\u5c11\u719f\u6089\u4e86\u8521\u5c11\u82ac\u2026\u2026&nbsp;<\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u770b\u4f3c\u98ce\u9a6c\u725b\u4e0d\u76f8\u53ca\u7684\u56db\u4e2a\u4eba\uff0c\u5374\u60a3\u6709\u4e00\u79cd\u5171\u540c\u7684\u75be\u75c5\u2014\u2014\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3002<\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5f3a\u76f4\u6027\u810a\u67f1\u708e\uff0c\u53c8\u88ab\u79f0\u4e3a\u4e0d\u6b7b\u7684\u764c\u75c7\uff0c\u662f\u4e00\u79cd\u6162\u6027\u98ce\u6e7f\u514d\u75ab\u7c7b\u75be\u75c5\uff0c\u4e3b\u8981\u4fb5\u72af\u810a\u67f1\u5173\u8282\u53ca\u5916\u5468\u5173\u8282\uff0c\u5178\u578b\u8868\u73b0\u4e3a\u708e\u6027\u8170\u80cc\u75db\uff0c\u53ef\u4f34\u53d1\u9aa8\u5173\u8282\u7834\u574f\u548c\u5173\u8282\u5916\u75c7\u72b6\uff0c\u4e25\u91cd\u8005\u53ef\u81f4\u810a\u67f1\u7578\u5f62\u548c\u5173\u8282\u5f3a\u76f4<\/span><span class=\"Apple-converted-space\" style=\"letter-spacing: 0px;box-sizing: border-box;\">&nbsp;<\/span><sup style=\"letter-spacing: 0px;box-sizing: border-box;\">2<\/sup><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u662f\u73b0\u4ee3\u533b\u5b66\u5c1a\u672a\u653b\u514b\u7684\u7591\u96be\u6742\u75c7\u4e4b\u4e00\uff0c\u60a3\u75c5\u7387\u9ad8\uff0c\u6211\u56fd\u60a3\u75c5\u7387\u4e3a 0.3%\uff5e0.5%\uff0c\u9ad8\u4e8e\u66f4\u4e3a\u4eba\u719f\u77e5\u7684\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u548c\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u7b49\u98ce\u6e7f\u514d\u75ab\u75c5\uff1b\u4e14\u60a3\u8005\u591a\u4e3a 18\uff5e40 \u5c81\u7684\u9752\u58ee\u5e74\u7537\u6027\uff0c\u8fd9\u610f\u5473\u7740\u6211\u56fd\u81f3\u5c11\u6709 500 \u4e07\u9752\u58ee\u5e74\u7537\u6027\u7f79\u60a3 AS\uff0c\u76f8\u5f53\u4e8e\u4e00\u4e2a\u7531\u4f18\u8d28\u52b3\u52a8\u529b\u7ec4\u6210\u7684\u4e2d\u7b49\u57ce\u5e02\u7684\u5168\u90e8\u4eba\u53e3\u6b8b\u75be\u3002\u540c\u65f6\uff0c\u8be5\u75c5\u81f4\u6b8b\u7387\u9ad8\uff0c\u793e\u4f1a\u5371\u5bb3\u5de8\u5927\u3002\u636e\u7edf\u8ba1\uff0c5% \u7684\u60a3\u8005\u5728\u786e\u8bca 1 \u5e74\u540e\u5373\u4e27\u5931\u52b3\u52a8\u529b\uff0c45% \u5728\u8d77\u75c5 10 \u5e74\u5185\u51fa\u73b0\u4e25\u91cd\u7684\u5173\u8282\u529f\u80fd\u969c\u788d\uff0c30% \u4ee5\u4e0a\u7684\u60a3\u8005 20 \u5e74\u540e\u5b8c\u5168\u4e0d\u80fd\u5de5\u4f5c\u3002\u66f4\u91cd\u8981\u7684\uff0c\u9752\u58ee\u5e74\u7537\u6027\u5e38\u56e0\u75c5\u75db\u65e0\u6cd5\u6b63\u5e38\u5de5\u4f5c\u548c\u751f\u6d3b\uff0c\u5bb9\u6613\u51fa\u73b0\u4e25\u91cd\u5fc3\u7406\u548c\u751f\u7406\u969c\u788d\u3002\u9707\u60ca\u5168\u56fd\u7684\u300c\u54c8\u5c14\u6ee8\u6740\u533b\u6848\u300d\u7684\u51f6\u624b\uff0c\u5c31\u6df1\u523b\u4f53\u73b0\u4e86 AS \u5bf9\u60a3\u8005\u8eab\u5fc3\u5065\u5eb7\u548c\u793e\u4f1a\u5b89\u5168\u7684\u5de8\u5927\u5f71\u54cd<\/span><span class=\"Apple-converted-space\" style=\"letter-spacing: 0px;box-sizing: border-box;\">&nbsp;<\/span><sup style=\"letter-spacing: 0px;box-sizing: border-box;\">3<\/sup><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: left;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;box-sizing: border-box;\">\n<section style=\"background-color: rgb(70, 85, 152);width: 1.6em;height: 1.6em;text-align: center;font-size: 18px;line-height: 1.6em;color: rgb(255, 255, 255);box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\">\n<p style=\"box-sizing: border-box;\">02<\/p>\n<\/section>\n<section style=\"width: 0px;margin-left: auto;border-width: 3px;border-style: solid;border-color: rgb(70, 85, 152) transparent transparent rgb(70, 85, 152);box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\"><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;margin-left: -6px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;height: 1.6em;line-height: 1.7em;background-color: rgb(240, 240, 240);text-align: center;padding-left: 10px;padding-right: 4px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"caret-color: rgb(51, 51, 51);text-align: justify;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">TNF-\u03b1\u6291\u5236\u5242\uff1aAS \u6cbb\u7597\u7684\u9769\u547d\u6027\u98de\u8dc3<\/span><sup style=\"caret-color: rgb(51, 51, 51);text-align: justify;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span class=\"Apple-converted-space\" style=\"box-sizing: border-box;\"><\/span>4<\/sup><\/strong><\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 0px;border-left: 0.8em solid rgb(240, 240, 240);border-top: 0.8em solid transparent !important;border-bottom: 0.8em solid transparent !important;box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"text-align: center;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"display: inline-block;width: 97%;vertical-align: top;padding: 15px;border-width: 0px;border-radius: 10px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;box-shadow: rgb(70, 85, 152) 0px 0px 6px;box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 15px;box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">AS \u7684\u6cbb\u7597\u5305\u62ec\u975e\u836f\u7269\u548c\u836f\u7269\u6cbb\u7597\u3002\u975e\u836f\u7269\u6cbb\u7597\u5305\u62ec\u60a3\u8005\u6559\u80b2\u3001\u953b\u70bc\u548c\u7269\u7406\u6cbb\u7597\u3002\u836f\u7269\u6cbb\u7597\u662f AS \u6cbb\u7597\u7684\u4e3b\u8981\u624b\u6bb5\uff0c\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u548c TNF-\u03b1\u6291\u5236\u5242\u662f AS \u6cbb\u7597\u7684\u4e00\u7ebf\u7528\u836f\u3002<\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">TNF-\u03b1\u662f\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\u5bb6\u65cf\u6700\u65e9\u88ab\u53d1\u73b0\u3001\u7814\u7a76\u6700\u6df1\u5165\u4e14\u6700\u65e9\u5e94\u7528\u4e8e\u4e34\u5e8a\u7684 TNF \u4e9a\u578b\uff0c\u4e3b\u8981\u7531\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\uff0c\u662f\u4e00\u7c7b\u5728\u708e\u75c7\u5e94\u7b54\u53cd\u5e94\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u9488\u5bf9\u8fd9\u4e00\u56e0\u5b50\u7814\u53d1\u751f\u7269\u5236\u5242\u6210\u4e3a\u4eba\u7c7b\u653b\u514b\u98ce\u6e7f\u75be\u75c5\u7684\u5207\u5165\u70b9\u3002\u8fd1\u5e74\u6765\uff0c\u591a\u79cd TNF \u62ee\u6297\u5242\u76f8\u7ee7\u83b7 FDA \u6279\u51c6\u4e0a\u5e02\uff0c\u56fd\u5185\u5916\u5927\u91cf\u7814\u7a76\u90fd\u5df2\u8bc1\u5b9e\uff0cTNF-\u03b1\u62ee\u6297\u5242\u5728\u7f13\u89e3 AS \u75c7\u72b6\u3001\u6297\u708e\u3001\u5ef6\u7f13\u75c5\u60c5\u8fdb\u5c55\u65b9\u9762\u6709\u660e\u663e\u7597\u6548\u3002\u56e0\u6b64\uff0c\u7f8e\u56fd\u98ce\u6e7f\u75c5\u5b66\u9662\u3001\u6b27\u6d32\u6297\u98ce\u6e7f\u75c5\u8054\u76df\u4ee5\u53ca\u6211\u56fd\u4e13\u5bb6\u5236\u5b9a\u7684 AS \u6cbb\u7597\u6307\u5357\u90fd\u5efa\u8bae\u5c3d\u65e9\u7ed9 AS \u60a3\u8005\u4f7f\u7528 TNF-\u03b1\u62ee\u6297\u5242\u3002TNF-\u03b1\u6291\u5236\u5242\u56e0\u6b64\u6210\u4e3a\u76ee\u524d\u56fd\u5185\u5916\u6cbb\u7597 AS \u4f7f\u7528\u6700\u4e3a\u5e7f\u6cdb\u3001\u4e34\u5e8a\u7814\u7a76\u652f\u6301\u6570\u636e\u6700\u591a\u7684\u751f\u7269\u5236\u5242\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u963f\u8fbe\u6728\u5355\u6297\u662f\u7ee7\u82f1\u592b\u5229\u6614\u5355\u6297\u548c\u4f9d\u90a3\u897f\u666e\u4e4b\u540e\uff0c\u7f8e\u56fd FDA \u6279\u51c6\u7684\u7b2c\u4e09\u79cd TNF \u6291\u5236\u5242\u7c7b\u836f\u7269\uff0c\u5176\u5728\u4e2d\u56fd\u5df2\u76f8\u7ee7\u83b7\u6279\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001AS \u548c\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u7b49\u591a\u79cd\u9002\u5e94\u75c7\u3002\u751f\u7269\u5236\u5242\u7684\u95ee\u4e16\u662f\u98ce\u6e7f\u6027\u75be\u75c5\u6cbb\u7597\u9886\u57df\u7684\u4e00\u6b21\u9769\u547d\u6027\u98de\u8dc3\u3002\u4f46\u963f\u8fbe\u6728\u5355\u6297\u4ef7\u683c\u6602\u8d35\uff0c\u8fdc\u8fdc\u8d85\u8fc7\u4e2d\u56fd\u666e\u901a\u60a3\u8005\u7684\u627f\u53d7\u80fd\u529b\u3002\u4e2d\u56fd\u60a3\u8005\u9700\u8981\u5c5e\u4e8e\u81ea\u5df1\u7684\u3001\u80fd\u7528\u5f97\u8d77\u7684 TNF-\u03b1\u62ee\u6297\u5242\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: left;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;box-sizing: border-box;\">\n<section style=\"background-color: rgb(70, 85, 152);width: 1.6em;height: 1.6em;text-align: center;font-size: 18px;line-height: 1.6em;color: rgb(255, 255, 255);box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\">\n<p style=\"box-sizing: border-box;\">03<\/p>\n<\/section>\n<section style=\"width: 0px;margin-left: auto;border-width: 3px;border-style: solid;border-color: rgb(70, 85, 152) transparent transparent rgb(70, 85, 152);box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\"><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;margin-left: -6px;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;height: 1.6em;line-height: 1.7em;background-color: rgb(240, 240, 240);text-align: center;padding-left: 10px;padding-right: 4px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"caret-color: rgb(51, 51, 51);text-align: justify;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">IBI303\uff1a\u4e2d\u56fd AS \u60a3\u8005\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u597d\u836f<\/span><\/strong><\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 0px;border-left: 0.8em solid rgb(240, 240, 240);border-top: 0.8em solid transparent !important;border-bottom: 0.8em solid transparent !important;box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"text-align: center;box-sizing: border-box;\"  class=\"_135editor\">\n<section style=\"display: inline-block;width: 97%;vertical-align: top;padding: 15px;border-width: 0px;border-radius: 10px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;box-shadow: rgb(70, 85, 152) 0px 0px 6px;box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 15px;box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u5e26\u7740\u300c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\u300d\u7684\u795e\u5723\u4f7f\u547d\uff0c\u4fe1\u8fbe\u751f\u7269\u5f00\u59cb\u4e86\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f IBI303 \u7684\u7814\u53d1\u5386\u7a0b\u3002\u836f\u5b66\u7814\u7a76\u8868\u660e IBI303 \u4e0e\u539f\u7814\u836f\u6c28\u57fa\u9178\u5e8f\u5217\u76f8\u540c\uff0c\u4f53\u5916\u751f\u7269\u5b66\u6d3b\u6027\uff08\u5bf9\u9776\u6297\u539f TNF-\u03b1\u7684\u7ed3\u5408\u6d3b\u6027\u53ca\u4e2d\u548c\u6d3b\u6027\uff09\u3001\u7406\u5316\u6027\u8d28\u3001\u751f\u7269\u6d3b\u6027\u548c\u836f\u7269\u4ee3\u8c22\u52a8\u529b\u5b66\u7279\u5f81\u3001\u836f\u7406\u6bd2\u7406\u7814\u7a76\u76f8\u7ee7\u88ab\u8bc1\u5b9e\u4e0e\u539f\u7814\u836f\u5177\u6709\u9ad8\u5ea6\u76f8\u4f3c\u6027\u3002\u5c0f\u6837\u672c\u4e34\u5e8a\u63a2\u7d22\u8bd5\u9a8c\u663e\u793a\u51fa IBI303 \u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u30022016 \u5e74 1 \u6708\uff0cIBI 303 \u83b7\u5f97\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u6279\u51c6\u6309\u7167\u300a\u751f\u7269\u7c7b\u4f3c\u53d1\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\uff08\u8bd5\u884c\uff09\u300b\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u987a\u5229\u5b8c\u6210\u5b89\u5168\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">2016 \u5e74 9 \u6708 13 \u65e5\uff0cIBI303 \u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u542f\u52a8\u3002\u6b64\u9879\u8bd5\u9a8c\u5c06\u5934\u5bf9\u5934\u6bd4\u5bf9 IBI303 \u548c\u963f\u8fbe\u6728\u5355\u6297\u5728\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u60a3\u8005\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\/\u751f\u7269\u7b49\u6548\u6027\uff08PK\/BE\uff09\uff0c\u5b89\u5168\u6027\u4ee5\u53ca\u6709\u6548\u6027\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u8fd9\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u7684\u539f\u7814\u836f\u5e73\u884c\u5bf9\u7167\u2162\u671f\u7814\u7a76\u5171\u6709 20 \u5bb6\u56fd\u5185\u533b\u5b66\u4e2d\u5fc3\u53c2\u4e0e\u3002\u53d7\u8bd5\u8005\u662f 18 \u5468\u5c81\u4ee5\u4e0a\uff0c\u975e\u753e\u4f53\u6297\u708e\u836f\u6cbb\u7597 4 \u5468\u4ee5\u4e0a\u7597\u6548\u4e0d\u4f73\u3001\u65e0\u6548\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u6d3b\u52a8\u6027\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u60a3\u8005\u3002\u76ae\u4e0b\u4e88\u4ee5 IBI303 \u6216\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\uff0c40 mg\/0.8 mL\uff0c\u6bcf\u4e24\u5468\u4e00\u6b21\uff0c\u5171 12 \u6b21\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u6cbb\u7597\u540e\u7b2c 24 \u5468\u8fbe\u5230 ASAS20 \u6539\u5584\u7a0b\u5ea6\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\uff08ASAS \u662f\u4e00\u79cd\u7528\u4e8e\u8bc4\u4f30 AS \u4e34\u5e8a\u6539\u5584\u7a0b\u5ea6\u7684\u6807\u51c6\u5de5\u5177\uff09<sup style=\"box-sizing: border-box;\">1<\/sup>\u3002<\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u7814\u7a76\u5171\u5165\u7ec4 438 \u540d\u60a3\u8005\uff08IBI303 \u7ec4\u548c\u963f\u8fbe\u6728\u5355\u6297\u7ec4\u5206\u522b\u4e3a 220 \u548c 218 \u4f8b\uff09\u3002\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0cIBI303 \u7ec4\u548c\u963f\u8fbe\u6728\u5355\u6297\u7ec4\u7b2c 24 \u5468 ASAS20 \u5e94\u7b54\u6709\u6548\u7387\u5206\u522b\u4e3a 75.0% \u548c 72.5%\uff0c\u4e34\u5e8a\u7b49\u6548\u6027\u6210\u7acb\u3002\u7814\u7a76\u4e5f\u8fbe\u5230\u4e86\u9884\u8bbe\u7684\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u7b2c 12 \u5468\u65f6\u7684 ASAS20 \u6709\u6548\u7387\u3001\u7b2c 24 \u5468 ASAS40\u3001ASAS \u90e8\u5206\u5e94\u7b54\u548c ASAS5\/6 \u5e94\u7b54\u7387\uff0c\u4ee5\u53ca BASDAI \u7b49 AS \u75be\u75c5\u8bc4\u4f30\u91cf\u8868\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u8fd9\u8bf4\u660e\u5728\u63a7\u5236 AS \u60a3\u8005\u7684\u75c5\u60c5\u6d3b\u52a8\u5ea6\u3001\u6539\u5584\u60a3\u8005\u7684\u8eaf\u4f53\u529f\u80fd\u3001\u810a\u67f1\u6d3b\u52a8\u5ea6\u3001\u808c\u8171\u7aef\u708e\u3001\u60a3\u8005\u603b\u4f53\u8bc4\u4f30\uff0c\u4ee5\u53ca\u63d0\u9ad8 AS \u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u65b9\u9762\uff0cIBI303 \u4e5f\u4e0e\u963f\u8fbe\u6728\u5355\u6297\u76f8\u4f3c\u3002\u6b64\u5916\uff0c\u5b89\u5168\u6027\u4e0e\u514d\u75ab\u539f\u6027\u7ed3\u679c\u4e5f\u63d0\u793a IBI303 \u5728\u60a3\u8005\u4e2d\u8010\u53d7\u6027\u8f83\u597d\u4e14\u4e0e\u539f\u7814\u836f\u76f8\u5173\u6307\u6807\u7c7b\u4f3c<span class=\"Apple-converted-space\" style=\"box-sizing: border-box;\"><\/span><sup style=\"box-sizing: border-box;\">1<\/sup>\u3002<\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">2011 \u5e74\u56fd\u9645\u810a\u67f1\u5173\u8282\u708e\u4e13\u5bb6\u8bc4\u4f30\u534f\u4f1a\uff08ASAS\uff09\/\u6b27\u6d32\u6297\u98ce\u6e7f\u8054\u76df EULAR \u5efa\u8bae\uff1aAS \u7684\u4e3b\u8981\u6cbb\u7597\u76ee\u6807\u662f\u901a\u8fc7\u63a7\u5236\u75c7\u72b6\u548c\u708e\u75c7\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\uff0c\u907f\u514d\u8fdc\u671f\u5173\u8282\u7578\u5f62\uff0c\u4fdd\u6301\u793e\u4ea4\u80fd\u529b\u3002\u53ef\u4ee5\u770b\u51fa\uff0cIBI303 \u8fd1\u4e4e\u5b8c\u7f8e\u7684\u8fbe\u5230\u4e86\u6743\u5a01\u673a\u6784\u5bf9 AS \u6cbb\u7597\u76ee\u6807\u7684\u5efa\u8bae\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u8be5\u7814\u7a76\u73b0\u5df2\u5168\u6587\u53d1\u8868\u4e8e\u67f3\u53f6\u5200\u5b50\u520a\uff0c\u540c\u671f\u520a\u53d1\u7684\u4e13\u5bb6\u8bc4\u8ff0\u6307\u51fa\uff0c\u8fc7\u53bb 15 \u5e74\u6765\uff0c\u751f\u7269\u7c7b\u4f3c\u836f\u6b63\u5728\u5927\u91cf\u8fdb\u5165\u4e34\u5e8a\u3002\u7ecf\u8fc7\u4e25\u683c\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u5176\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u7684\u7b49\u6548\u6027\u548c\u7c7b\u4f3c\u6027\u540e\uff0c\u5df2\u6709\u591a\u79cd\u963f\u8fbe\u6728\u5355\u6297\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u540e\u8fdb\u5165\u4e34\u5e8a\uff0c\u4f46\u4e2d\u56fd\u5c1a\u65e0\u963f\u8fbe\u6728\u5355\u6297\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u3002IBI303 \u662f\u7b2c\u4e00\u4e2a\u5728\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u60a3\u8005\u4e2d\u88ab\u8bc1\u5b9e\u4e0e\u963f\u8fbe\u6728\u5355\u6297\u5177\u6709\u7b49\u6548\u6027\u548c\u7c7b\u4f3c\u6027\u7684\u751f\u7269\u7c7b\u4f3c\u7269\uff0c\u5b83\u7684\u6210\u529f\u7814\u53d1\u548c III \u671f\u4e34\u5e8a\u5b8c\u6210\u6807\u5fd7\u7740\u4e2d\u56fd\u6b63\u5f0f\u8fdb\u5165\u4e86\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u5927\u5bb6\u5ead\uff0c\u671f\u5f85 IBI303 \u65e9\u65e5\u83b7\u6279\u80fd\u591f\u663e\u8457\u964d\u4f4e\u5305\u62ec\u4e2d\u56fd\u5728\u5185\u7684\u4e00\u4e9b\u56fd\u5bb6\u7684 AS \u6cbb\u7597\u8d39\u7528\uff0c\u6ee1\u8db3\u6211\u4eec\u5bf9\u63d0\u9ad8\u963f\u8fbe\u6728\u5355\u6297\u7b49\u9ad8\u6548\u836f\u7269\u53ef\u53ca\u6027\u7684\u671f\u8bb8\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\">\u636e\u6089\uff0c\u6b64\u524d\uff0cIBI303 \u5df2\u5411\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5e76\u88ab\u53d7\u7406\uff0c\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u67f3\u53f6\u5200\u5b50\u520a\u7684\u53d1\u8868\uff0c\u5145\u5206\u663e\u793a\u4e86\u4fe1\u8fbe\u5236\u836f\u5728\u751f\u7269\u7c7b\u4f3c\u836f\u65b9\u9762\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e5f\u6807\u5fd7\u7740\u4ee5\u5f90\u6caa\u6d4e\u6559\u6388\u4e3a\u4ee3\u8868\u7684\u4e2d\u56fd\u7814\u7a76\u8005\u5728\u76f8\u5173\u75be\u75c5\u6cbb\u7597\u9886\u57df\u7684\u4e34\u5e8a\u7814\u53d1\u80fd\u529b\u8fbe\u5230\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u3002\u5fc5\u5c06\u4e3a IBI303 \u7684\u4e0a\u5e02\u63d0\u4f9b\u6781\u5927\u52a9\u529b\u3002\u6211\u4eec\u671f\u5f85 IBI 303 \u65e9\u65e5\u4e0a\u5e02\u5e76\u8d70\u8fdb AS \u60a3\u8005\u5bb6\u4e2d\uff0c\u63d0\u9ad8\u963f\u8fbe\u6728\u5355\u6297\u7684\u836f\u7269\u53ef\u53ca\u6027\uff0c\u4e3a\u5e7f\u5927\u60a3\u8005\u63d0\u4f9b\u4e00\u4e2a\u9ad8\u8d28\u91cf\u3001\u4f4e\u4ef7\u683c\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u8ba9\u66f4\u591a\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u53ca\u65e9\u53d7\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<section style=\"box-sizing: border-box;\"  class=\"_135editor\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"color: rgb(142, 141, 141);font-size: 13px;white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 12px;color: #A0A0A0;box-sizing: border-box;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"font-size: 12px;color: #A0A0A0;box-sizing: border-box;\">1.&nbsp;Xu HJ\uff0cet al. IBI303, a biosimilar to adalimumab, for the treatment of&nbsp;patients with ankylosing spondylitis in China: a randomised,&nbsp;double-blind, phase 3 equivalence trial.&nbsp;Lancet Rheumatol 2019;1: e35\u201343<\/span><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"color: #A0A0A0;font-size: 12px;letter-spacing: 0px;box-sizing: border-box;\">2.&nbsp;Stanley B Cohen Biosimilars for rheumatic diseases: China joins the club. Lancet Rheumatol 2019; 1: e5-e7,<\/span><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"font-size: 12px;color: #A0A0A0;box-sizing: border-box;\">3. &nbsp;\u9ec4\u8096\u5065\uff0c\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u961f\u5217\u7814\u7a76\u7684\u57fa\u7ebf\u671f\u4e34\u5e8a\u6570\u636e\u5206\u6790\uff0c\u89e3\u653e\u519b\u603b\u533b\u9662\u7855\u58eb\u6bd5\u4e1a\u8bba\u6587.<\/span><\/p>\n<p style=\"margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"font-size: 12px;color: #A0A0A0;box-sizing: border-box;\">4. &nbsp;\u6768\u51b0\u7b49\uff0c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-a \u6cbb\u7597\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u7814\u7a76\u8fdb\u5c55\u4e2d\u56fd\u533b\u836f\u5bfc\u62a5 2013\uff1b10\uff0814\uff09\uff1a36-8<\/span><\/p>\n<p style=\"text-align:right;margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><br  \/><\/p>\n<p style=\"text-align:right;margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"font-size: 12px;color: #B2B2B2;\">\u5c01\u9762\u56fe\u6765\u6e90\uff1a\u300a\u67f3\u53f6\u5200 Lancet\u300b<\/span><\/p>\n<p style=\"text-align:right;margin-top: 5px;padding-bottom: 25px;overflow-wrap: break-word;caret-color: rgb(51, 51, 51);font-size: 14px;white-space: normal;text-size-adjust: auto;box-sizing: border-box;font-family: Avenir, sans-serif;\"><span style=\"font-size: 12px;color: #B2B2B2;\">\u8d23\u4efb\u7f16\u8f91\uff1a<\/span><span style=\"font-size: 12px;color: #B2B2B2;\">\u5218\u747e<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6982 \u89c8 \u8fd9\u662f\u56fd\u9645\u4e0a\u9996\u6b21\u516c\u5f00\u53d1\u8868\u7684\u5173\u4e8e\u751f\u7269\u7c7b\u4f3c\u836f\u548c\u539f\u7814\u836f\u5728\u6d3b\u52a8\u6027 AS \u60a3\u8005\u4e2d\u7684\u5927\u578b\u5934\u5bf9\u5934\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e5f\u662f\u4e2d\u56fd [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":124652,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/124651"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=124651"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/124651\/revisions"}],"predecessor-version":[{"id":124653,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/124651\/revisions\/124653"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/124652"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=124651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=124651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=124651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}