{"id":125993,"date":"2019-10-07T11:58:40","date_gmt":"2020-04-21T02:13:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/125993\/"},"modified":"2020-04-21T10:13:06","modified_gmt":"2020-04-21T02:13:06","slug":"cd3259b838","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/125993\/","title":{"rendered":"\u4ec0\u4e48\u662f\u6c27\u611f\u77e5\u901a\u8def\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e2e\u4f60\u770b\u61c2\u4eca\u5e74\u7684\u8bfa\u5956\u6210\u679c"},"content":{"rendered":"
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2019 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u4e8e\u5317\u4eac\u65f6\u95f4 10 \u6708 7 \u65e5\u4e0b\u5348 5 \u70b9 30 \u5206\u516c\u5e03\uff0c\u4eca\u5e74\u7684\u83b7\u5956\u8005\u6709\u4e09\u4f4d\uff0c\u4ed6\u4eec\u5206\u522b\u662f\u6765\u81ea\u54c8\u4f5b\u533b\u5b66\u9662\u8fbe\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240\u7684\u5a01\u5ec9\u00b7\u51ef\u6797\uff08 William G. Kaelin, Jr.\uff09\uff0c\u725b\u6d25\u5927\u5b66\u548c\u5f17\u6717\u897f\u65af\u00b7\u514b\u91cc\u514b\u7814\u7a76\u6240\u7684\u5f7c\u5f97\u00b7\u62c9\u7279\u514b\u5229\u592b\uff08 Peter J. Ratcliffe\uff09 \u4ee5\u53ca\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u533b\u5b66\u9662\u7684\u683c\u96f7\u683c\u00b7\u585e\u95e8\u624e\uff08Gregg L. Semenza\uff09\u3002<\/span><\/span><\/p>\n


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\u4ed6\u4eec\u56e0\u5728<\/span>\u6c27\u611f\u77e5\u901a\u8def\u65b9\u9762\u7684\u7814\u7a76\u505a\u51fa\u7684\u8d21\u732e\u800c\u83b7\u5956\u3002\u4ee5\u4e0b\u662f\u7f16\u8bd1\u81ea\u8bfa\u8d1d\u5c14\u5956\u5b98\u65b9\u7f51\u7ad9\u4e0a\uff0c\u5bf9\u4e8e\u51e0\u4f4d\u79d1\u5b66\u5bb6\u7814\u7a76\u6210\u679c\u7684\u4ecb\u7ecd\u3002<\/span><\/span><\/span><\/p>\n


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\"\u4ec0\u4e48\u662f\u6c27\u611f\u77e5\u901a\u8def\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e2e\u4f60\u770b\u61c2\u4eca\u5e74\u7684\u8bfa\u5956\u6210\u679c\"<\/section>\n

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\u6458\u8981<\/span><\/strong><\/span><\/span><\/p>\n


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\u52a8\u7269\u9700\u8981\u6c27\u6c14\u624d\u80fd\u5c06\u98df\u7269\u8f6c\u5316\u4e3a\u6709\u7528\u7684\u80fd\u91cf\u3002\u51e0\u4e2a\u4e16\u7eaa\u4ee5\u6765\uff0c\u4eba\u4eec\u81f4\u529b\u4e8e\u7814\u7a76\u6c27\u6c14\u5bf9\u4e8e\u673a\u4f53\u7684\u91cd\u8981\u6027\uff0c\u4f46\u4eba\u4eec\u4e00\u76f4\u641e\u4e0d\u6e05\u695a\u7ec6\u80de\u5982\u4f55\u9002\u5e94\u6c27\u6c14\u6c34\u5e73\u7684\u53d8\u5316\u3002<\/span><\/p>\n


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William G. Kaelin\u3001Sir Peter J. Ratcliffe \u548c Gregg L. Semenza\uff0c\u4ed6\u4eec\u53d1\u73b0\u4e86\u53ef\u4ee5\u8c03\u8282\u57fa\u56e0\u6d3b\u6027\u4ee5\u5e94\u5bf9\u4e0d\u540c\u6c27\u6c14\u6d53\u5ea6\u53d8\u5316\u7684\u5206\u5b50\u673a\u5236\u3002<\/span><\/p>\n


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\u4eca\u5e74\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005\u5f00\u521b\u6027\u7684\u53d1\u73b0\uff0c\u63ed\u793a\u4e86\u751f\u547d\u4e2d\u6700\u91cd\u8981\u7684\u9002\u5e94\u8fc7\u7a0b\u4e4b\u4e00\u7684\u673a\u5236\u3002\u4ed6\u4eec\u4e3a\u6211\u4eec\u4e86\u89e3\u6c27\u6c14\u6c34\u5e73\u5982\u4f55\u5f71\u54cd\u7ec6\u80de\u4ee3\u8c22\u548c\u751f\u7406\u529f\u80fd\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/span><\/p>\n


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\u4ed6\u4eec\u7684\u53d1\u73b0\u4e5f\u4e3a\u6cbb\u7597<\/span>\u8d2b\u8840\u3001\u764c\u75c7\u548c\u8bb8\u591a\u5176\u4ed6\u75be\u75c5<\/span>\u7684\u65b0\u65b9\u6cd5\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/span><\/p>\n


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\u6c27\u6c14\uff1a\u521d\u767b\u821e\u53f0<\/span><\/strong><\/span><\/span><\/p>\n


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\u6c27\u6c14\u7ea6\u5360\u5730\u7403\u5927\u6c14\u5c42\u7684\u4e94\u5206\u4e4b\u4e00\uff0c\u5bf9\u52a8\u7269\u751f\u547d\u81f3\u5173\u91cd\u8981\uff1a\u51e0\u4e4e\u6240\u6709\u52a8\u7269\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u90fd\u4f1a\u5229\u7528\u6c27\u6c14\uff0c\u5c06\u98df\u7269\u8f6c\u5316\u4e3a\u6709\u7528\u7684\u80fd\u91cf\u3002<\/span><\/p>\n


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Otto Warburg \u662f 1931 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u7684\u83b7\u5f97\u8005\uff0c\u4ed6\u63ed\u793a\u4e86\u8fd9\u79cd\u8f6c\u6362\u662f\u6709\u9176\u53c2\u4e0e\u4fc3\u8fdb\u7684\u8fc7\u7a0b\u3002<\/span><\/p>\n


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\u673a\u4f53\u9010\u6e10\u8fdb\u5316\u51fa\u786e\u4fdd\u5411\u7ec4\u7ec7\u548c\u7ec6\u80de\u5145\u5206\u4f9b\u6c27\u7684\u673a\u5236\u3002\u9888\u52a8\u8109\u4f53\u4e0e\u9888\u90e8\u4e24\u4fa7\u7684\u5927\u8840\u7ba1\u76f8\u90bb\uff0c\u5305\u542b\u4e86\u4e13\u95e8\u611f\u5e94\u8840\u6db2\u4e2d\u6c27\u6c14\u6c34\u5e73\u7684\u7ec6\u80de\u30021938 \u5e74\uff0cCorneille Heymans \u83b7\u5f97\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff0c\u5c31\u662f\u5956\u52b1\u4ed6\u53d1\u73b0\u4e86\u9888\u52a8\u8109\u4f53\u548c\u4e3b\u52a8\u8109\u4f53\u611f\u77e5\u8840\u6c27\u6c34\u5e73\u5e76\u901a\u8fc7\u795e\u7ecf\u4e2d\u67a2\u8c03\u8282\u547c\u5438\u9891\u7387\u7684\u4f5c\u7528\u3002<\/span><\/p>\n


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HIF\uff1a\u8fdb\u5165\u89c6\u91ce<\/span><\/strong><\/span><\/span><\/p>\n


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\u9664\u4e86\u9888\u52a8\u8109\u4f53\u53ef\u4ee5\u5e94\u5bf9\u4f4e\u6c27\u6c34\u5e73\uff08\u4f4e\u6c27\uff09\u8fdb\u884c\u5feb\u901f\u8c03\u8282\u5916\uff0c\u8fd8\u6709\u5176\u4ed6\u4e00\u4e9b\u57fa\u672c\u7684\u751f\u7406\u9002\u5e94\u6027\u3002\u5bf9\u7f3a\u6c27\u7684\u4e3b\u8981\u751f\u7406\u53cd\u5e94\u662f\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u6c34\u5e73\u7684\u5347\u9ad8\uff0c\u8fd9\u4f1a\u523a\u6fc0\u7ea2\u7ec6\u80de\u751f\u6210\u3002\u6fc0\u7d20\u63a7\u5236\u7ea2\u7ec6\u80de\u751f\u6210\u7684\u91cd\u8981\u6027\uff0c\u5728 20 \u4e16\u7eaa\u521d\u5c31\u5df2\u4e3a\u4eba\u6240\u77e5\uff0c\u4f46\u662f\u8fd9\u79cd\u8fc7\u7a0b\u5982\u4f55\u7531\u6c27\u6c14\u6d53\u5ea6\u63a7\u5236\uff0c\u4ecd\u7136\u662f\u4e2a\u8c1c\u3002<\/span><\/p>\n


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Gregg Semenza \u7814\u7a76\u4e86 EPO \u57fa\u56e0\uff0c\u4ee5\u53ca\u5982\u4f55\u6839\u636e\u6c27\u6c14\u6d53\u5ea6\u6765\u8c03\u8282\u5b83\u3002\u901a\u8fc7\u4f7f\u7528\u57fa\u56e0\u4fee\u9970\u7684\u5c0f\u9f20\uff0c\u663e\u793a\u4f4d\u4e8e EPO \u57fa\u56e0\u65c1\u8fb9\u7684\u7279\u5b9a DNA \u7247\u6bb5\u4ecb\u5bfc\u4e86\u7ec6\u80de\u5bf9\u7f3a\u6c27\u7684\u53cd\u5e94\u3002<\/span>Sir Peter Ratcliffe \u8fd8\u7814\u7a76\u4e86 EPO \u57fa\u56e0<\/span>\u7684\u6c27\u6c14<\/span>\u4f9d\u8d56\u6027\u8c03\u8282\u3002<\/span><\/p>\n


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<\/span>\u4e24\u4e2a\u7814\u7a76\u5c0f\u7ec4\u90fd\u53d1\u73b0\uff0c\u51e0\u4e4e\u6240\u6709\u7ec4\u7ec7\u4e2d\u90fd\u5b58\u5728\u6c27\u4f20\u611f\u673a\u5236\uff0c\u800c\u4e0d\u4ec5\u5b58\u5728\u4e8e\u901a\u5e38<\/span>\u4ea7\u751f EPO \u7684\u80be\u7ec6\u80de\u4e2d\u3002<\/span>\u8fd9\u4e9b\u91cd\u8981\u53d1\u73b0\u8868\u660e\uff0c\u8be5\u673a\u5236\u5728\u8bb8\u591a\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u4e2d\u662f\u901a\u7528\u7684\uff0c\u800c\u4e14\u90fd\u5177\u6709\u4f5c\u7528\u3002<\/span><\/p>\n


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Semenza \u5e0c\u671b\u786e\u5b9a\u4ecb\u5bfc\u8fd9\u79cd\u53cd\u5e94\u7684\u7ec6\u80de\u6210\u5206\u3002\u5728\u57f9\u517b\u7684\u809d\u7ec6\u80de\u4e2d\uff0c\u4ed6\u53d1\u73b0\u4e86\u4e00\u79cd\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u8be5\u590d\u5408\u7269\u4ee5\u4e00\u79cd\u6c27\u4f9d\u8d56\u6027\u7684\u65b9\u5f0f\u4e0e\u5df2\u9274\u5b9a\u51fa\u7684 DNA \u7247\u6bb5\u7ed3\u5408\u3002\u4ed6\u79f0\u8fd9\u79cd\u590d\u5408\u7269\u4e3a\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08HIF\uff09\u3002<\/span><\/p>\n


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1995 \u5e74\u4ed6\u5f00\u59cb\u4e86\u7eaf\u5316 HIF \u590d\u5408\u7269\u7684\u5de5\u4f5c\uff0c\u968f\u540e Semenza \u53d1\u8868\u4e86\u90e8\u5206\u5173\u952e\u7814\u7a76\u7ed3\u679c\uff0c\u5176\u4e2d\u5305\u62ec\u660e\u786e HIF \u7f16\u7801\u57fa\u56e0\u3001\u53d1\u73b0 HIF \u7531\u4e24\u79cd\u4e0d\u540c\u7684 DNA \u7ed3\u5408\u86cb\u767d\u7ec4\u6210\uff08\u5373\u6240\u8c13\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u73b0\u5728\u79f0\u4e3a HIF-1\u03b1<\/span> \u548c ARNT\uff09\u3002\u73b0\u5728\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u7740\u624b\u7814\u7a76 HIF \u7684\u5176\u4ed6\u6210\u5206\u4ee5\u53ca\u8fd0\u4f5c\u673a\u5236\u3002<\/span><\/p>\n


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VHL\uff1a<\/span><\/strong><\/span>\u610f\u60f3\u4e0d\u5230\u7684\u4f19\u4f34<\/span><\/strong><\/span><\/span><\/p>\n


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\u5f53\u673a\u4f53\u91cc\u7684\u6c27\u6d53\u5ea6\u5f88\u9ad8\u65f6\uff0c\u7ec6\u80de\u4e2d\u51e0\u4e4e\u4e0d\u542b HIF-1\u03b1<\/span>\uff0c\u5f53\u673a\u4f53\u6c27\u6d53\u5ea6\u504f\u4f4e\u65f6\uff0cHIF-1\u03b1<\/span> \u7684\u542b\u91cf\u5347\u9ad8\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u53ef\u4ee5<\/span>\u7ed3\u5408\u5e76\u8c03\u8282 EPO \u57fa\u56e0\u4ee5\u53ca\u5176\u4ed6\u5177\u6709 HIF \u7ed3\u5408 DNA \u7247\u6bb5\u7684\u57fa\u56e0\uff08\u56fe 1\uff09\u3002<\/span> <\/span><\/p>\n


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2004 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b Aaron Ciechanover\uff0cAvram Hershko \u548c Irwin Rose \u53d1\u73b0\uff0c\u5728\u6b63\u5e38\u7684\u6c27\u6c14\u6c34\u5e73\u4e0b\uff0c\u4e00\u79cd\u5c0f\u80bd\u6cdb\u7d20\u88ab\u6dfb\u52a0\u5230 HIF-1\u03b1 \u86cb\u767d\u4e2d\uff0c\u8fd9\u79cd\u6cdb\u7d20\u6807\u8bb0\u4f7f\u5f97 HIF-1\u03b1 \u5728\u86cb\u767d\u9176\u4f53\u4e2d\u88ab\u964d\u89e3\u3002<\/span><\/p>\n


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<\/span>\u6b64\u5916\uff0c\u51e0\u4e2a\u7814\u7a76\u5c0f\u7ec4\u90fd\u8868\u660e\uff0c\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u539f\u672c\u88ab\u8fc5\u901f\u964d\u89e3\u7684 HIF-1\u03b1 \u901a\u5e38\u4e0d\u4f1a\u88ab\u7ee7\u7eed\u964d\u89e3\u3002<\/span> \u7136\u800c\uff0c\u6cdb\u7d20\u5982\u4f55\u4ee5\u6c27\u4f9d\u8d56\u6027\u65b9\u5f0f\u7ed3\u5408 HIF-1\u03b1 \u4ecd\u7136\u662f\u4e00\u4e2a\u5173\u952e\u95ee\u9898\u3002<\/span><\/p>\n


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\u7b54\u6848\u6765\u81ea\u4e00\u4e2a\u610f\u60f3\u4e0d\u5230\u7684\u65b9\u5411\u3002<\/span><\/p>\n


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Ratcliffe \u4e0e Semenza \u5927\u7ea6\u540c\u65f6\u5728\u63a2\u7d22 EPO \u57fa\u56e0\u7684\u8c03\u63a7\uff0c\u764c\u75c7\u7814\u7a76\u8005 William Kaelin\uff0cJr. \u6b63\u5728\u7814\u7a76\u4e00\u79cd\u9057\u4f20\u7efc\u5408\u5f81\uff0c\u5373 von Hippel-Lindau \u75c5\uff08VHL \u75c5\uff09\u3002\u8fd9\u79cd\u9057\u4f20\u75be\u75c5\u4f1a\u5bfc\u81f4\u9057\u4f20\u6027 VHL \u7a81\u53d8\u7684\u5bb6\u5ead\u7f79\u60a3\u67d0\u4e9b\u764c\u75c7\u7684\u98ce\u9669\u6025\u5267\u589e\u52a0\u3002<\/span><\/p>\n


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Kaelin \u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cVHL \u57fa\u56e0\u53ef\u4ee5\u7f16\u7801\u4ea7\u751f\u5177\u6709\u9884\u9632\u764c\u75c7\u53d1\u751f\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002\u6b64\u5916\uff0c\u7f3a\u4e4f\u529f\u80fd\u6027 VHL \u57fa\u56e0\u7684\u764c\u7ec6\u80de\u4f1a\u5f02\u5e38\u9ad8\u6c34\u5e73\u8868\u8fbe\u4f4e\u6c27\u8c03\u8282\u57fa\u56e0\uff0c\u4f46\u662f\u5c06 VHL \u57fa\u56e0\u91cd\u65b0\u5f15\u5165\u764c\u7ec6\u80de\u540e\uff0c\u4f4e\u6c27\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\u53ef\u6062\u590d\u6b63\u5e38\u6c34\u5e73\u3002<\/span><\/p>\n


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\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u7ebf\u7d22\uff0c\u8868\u660e VHL \u4ee5\u67d0\u79cd\u65b9\u5f0f\u53c2\u4e0e\u4e86\u5bf9\u7f3a\u6c27\u53cd\u5e94\u7684\u63a7\u5236\u3002<\/span><\/p>\n


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\u6765\u81ea\u51e0\u4e2a\u7814\u7a76\u5c0f\u7ec4\u7684\u5176\u4ed6\u7ebf\u7d22\u8868\u660e\uff0cVHL \u662f\u590d\u5408\u7269\u7684\u4e00\u90e8\u5206\u3002\u8be5\u590d\u5408\u7269\u7528\u6cdb\u7d20\u6807\u8bb0\u86cb\u767d\u8d28\uff0c\u88ab\u6cdb\u7d20\u6807\u8bb0\u7684\u86cb\u767d\u8d28\u968f\u540e\u88ab\u86cb\u767d\u9176\u4f53\u964d\u89e3\u3002Ratcliffe \u53ca\u5176\u7814\u7a76\u5c0f\u7ec4\u968f\u540e\u6709\u4e00\u4e2a\u5173\u952e\u53d1\u73b0\uff1a\u4ed6\u4eec\u8bc1\u660e\u4e86\u673a\u4f53\u5728\u6b63\u5e38\u6c27\u6d53\u5ea6\u4e0b\u964d\u89e3 VHL\u9700\u8981\u901a\u8fc7 VHL \u4e0e HIF-1\u03b1<\/span> \u53d1\u751f\u7269\u7406\u76f8\u4e92\u4f5c\u7528\u5b9e\u73b0\uff0c\u8fd9\u6700\u7ec8\u5c06 VHL \u4e0e HIF-1\u03b1 <\/span><\/span>\u8054\u7cfb\u5230\u4e86\u4e00\u8d77<\/span>\u3002<\/span><\/p>\n


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\u8bb8\u591a\u7814\u7a76\u7ed3\u679c\u90fd\u5df2\u7ecf\u5c31\u4f4d\uff0c\u4f46\u662f\u4ecd\u7136\u7f3a\u5c11\u5bf9\u6c27\u6c14\u6c34\u5e73\u5982\u4f55\u8c03\u8282 VHL \u548c HIF-1\u03b1<\/span> \u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u89e3\u3002\u7814\u7a76\u7684\u91cd\u70b9\u533a\u57df\u5728\u5df2\u77e5\u5bf9 VHL \u964d\u89e3\u5177\u6709\u91cd\u8981\u4f5c\u7528\u7684 HIF-1\u03b1<\/span> \u86cb\u767d\u7684\u7279\u5b9a\u90e8\u5206\uff0cKaelin \u548c Ratcliffe \u90fd\u6000\u7591\u6c27\u6c14\u611f\u6d4b\u7684\u5173\u952e\u4f4d\u4e8e\u8be5\u86cb\u767d\u7ed3\u6784\u57df\u7684\u67d0\u4e2a\u4f4d\u7f6e\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728 2001 \u5e74\uff0c\u4ed6\u4eec\u5728\u4e24\u7bc7\u540c\u65f6\u53d1\u8868\u7684\u6587\u7ae0\u4e2d\u8868\u660e\uff0c\u5728\u6b63\u5e38\u7684\u6c27\u6c14\u6c34\u5e73\u4e0b\uff0cHIF-1\u03b1<\/span> \u86cb\u767d\u7684\u4e24\u4e2a\u7279\u5b9a\u4f4d\u7f6e\u4f1a\u6dfb\u52a0\u7f9f\u57fa\uff08\u56fe 1\uff09\u3002\u8fd9\u79cd\u86cb\u767d\u8d28\u4fee\u9970\uff08\u79f0\u4e3a\u812f\u6c28\u9170\u7f9f\u5316\uff09\u4f7f VHL \u80fd\u591f\u8bc6\u522b\u5e76\u7ed3\u5408\u5230 HIF-1\u03b1<\/span>\uff0c\u4ece\u800c\u89e3\u91ca\u4e86\u6b63\u5e38\u7684\u6c27\u6c14\u6c34\u5e73\u5982\u4f55\u901a\u8fc7\u5bf9\u6c27\u654f\u611f\u7684\u9176\uff08\u6240\u8c13\u7684\u812f\u6c28\u9170\u7f9f\u5316\u9176\uff09\u6765\u63a7\u5236 HIF-1\u03b1<\/span> \u7684\u5feb\u901f\u964d\u89e3\u3002 <\/span><\/p>\n


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Ratcliffe \u7b49\u4eba\u7684\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u786e\u5b9a\u4e86\u7279\u5b9a\u7684\u812f\u6c28\u9170\u7f9f\u5316\u9176\uff0c\u5e76\u8868\u660e HIF-1\u03b1<\/span> \u7684\u57fa\u56e0\u6fc0\u6d3b\u529f\u80fd\u53d7\u6c27\u6c14\u4f9d\u8d56\u6027\u7f9f\u57fa\u5316\u4f5c\u7528\u7684\u8c03\u8282\u3002\u81f3\u6b64\uff0c\u4e09\u4f4d\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005\uff0c\u5df2\u7ecf\u9610\u660e\u4e86\u6c27\u6c14\u611f\u5e94\u673a\u5236\uff0c\u5e76\u5c55\u793a\u4e86\u5176\u5de5\u4f5c\u539f\u7406\u3002<\/span><\/p>\n


<\/p>\n

\"\u4ec0\u4e48\u662f\u6c27\u611f\u77e5\u901a\u8def\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e2e\u4f60\u770b\u61c2\u4eca\u5e74\u7684\u8bfa\u5956\u6210\u679c\"<\/section>\n

\u56fe1\uff1a<\/span>\u5f53\u6c27\u6c34\u5e73\u4f4e\uff08\u4f4e\u6c27\uff09\u65f6\uff0cHIF-1<\/span>\u03b1<\/span> \u88ab\u4fdd\u62a4\u514d\u4e8e\u964d\u89e3\uff0c\u79ef\u805a\u5728\u7ec6\u80de\u6838\u4e2d\uff0c\u4e0e ARNT \u53ca\u4f4e\u6c27\u8c03\u8282\u57fa\u56e0\u4e2d\u7684\u7279\u5b9a DNA \u5e8f\u5217\uff08HRE\uff09\u7ed3\u5408\uff081\uff09\u3002<\/span>\u5728\u6b63\u5e38\u7684\u6c27\u6c14\u6c34\u5e73\u4e0b\uff0cHIF-1<\/span>\u03b1<\/span> \u88ab\u86cb\u767d\u9176\u4f53\u8fc5\u901f\u964d\u89e3\uff082\uff09\u3002<\/span>\u6c27\u6c14\u901a\u8fc7\u5411 HIF-1<\/span>\u03b1<\/span> \u6dfb\u52a0\u7f9f\u57fa\uff08OH\uff09\u6765\u8c03\u8282\u964d\u89e3\u8fc7\u7a0b\uff083\uff09\u3002<\/span>\u968f\u540e\uff0cVHL \u86cb\u767d\u53ef\u4ee5\u8bc6\u522b HIF-1<\/span>\u03b1<\/span> \u5e76\u4e0e\u4e4b\u5f62\u6210\u590d\u5408\u7269\uff0c\u4ece\u800c\u5bfc\u81f4\u5176\u4ee5\u6c27\u4f9d\u8d56\u6027\u65b9\u5f0f\u964d\u89e3\uff084\uff09\u3002<\/span>
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\u6c27\u6c14\u5f71\u54cd\u7684\u751f\u7406\u548c\u75c5\u7406<\/span><\/strong><\/span><\/span><\/p>\n


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\u4e0e\u6c27\u611f\u77e5\u901a\u8def\u76f8\u5173\u7684\u5176\u4ed6\u9002\u5e94\u6027\u8fc7\u7a0b\u8fd8\u5305\u62ec\uff0c\u65b0\u8840\u7ba1\u7684\u4ea7\u751f\u548c\u7ea2\u7ec6\u80de\u7684\u4ea7\u751f\u3002\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u548c\u8bb8\u591a\u5176\u4ed6\u751f\u7406\u529f\u80fd\u4e5f\u53ef\u4ee5\u901a\u8fc7\u6c27\u611f\u77e5\u901a\u8def\u8fdb\u884c\u5fae\u8c03\u3002\u6b64\u5916\uff0c\u5728\u80ce\u513f\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u6c27\u611f\u77e5\u901a\u8def\u5bf9\u63a7\u5236\u6b63\u5e38\u7684\u8840\u7ba1\u5f62\u6210\u548c\u80ce\u76d8\u53d1\u80b2\uff0c\u5df2\u88ab\u8bc1\u660e\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002<\/span><\/p>\n


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\"\u4ec0\u4e48\u662f\u6c27\u611f\u77e5\u901a\u8def\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e2e\u4f60\u770b\u61c2\u4eca\u5e74\u7684\u8bfa\u5956\u6210\u679c\"<\/section>\n

\u56fe2 \u83b7\u5956\u7684\u6c27\u611f\u5e94\u673a\u5236\u5728\u751f\u7406\u5b66\u4e2d\u7684\u65b0\u9648\u4ee3\u8c22\u3001\u514d\u75ab\u53cd\u5e94\u548c\u9002\u5e94\u8fd0\u52a8\u7b49\u90fd<\/span>\u5177\u6709\u6781\u5176\u91cd\u8981\u7b49\u4f5c\u7528\u3002\u6b64\u5916\uff0c<\/span>\u8bb8\u591a\u75c5\u7406\u8fc7\u7a0b\u4e5f\u4f1a\u53d7\u5230\u5f71\u54cd\u3002\u8bb8\u591a\u7814\u7a76\u5ba4\u4e0e\u5236\u836f\u516c\u53f8<\/span>\u6b63\u5728\u4e0d\u65ad\u52aa\u529b\u5f00\u53d1\u53ef\u4ee5\u6291\u5236\u6216\u6fc0\u6d3b\u6c27\u8c03\u8282\u673a\u5236\u7684\u65b0\u836f\uff0c\u4ee5\u6cbb\u7597\u8d2b\u8840\uff0c\u764c\u75c7\u548c\u5176\u4ed6\u75be\u75c5\u3002<\/span>
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\u8d23\u4efb\u7f16\u8f91\uff1a\u8d39\u83f2\u3001\u5218\u6631<\/span><\/section>\n
\u9898\u56fe\u3001\u63d2\u56fe\u4e0e\u8d44\u6599\u6765\u6e90\uff1awww.nobelprize.org<\/span><\/section>\n
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\"\u4ec0\u4e48\u662f\u6c27\u611f\u77e5\u901a\u8def\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e2e\u4f60\u770b\u61c2\u4eca\u5e74\u7684\u8bfa\u5956\u6210\u679c\"<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

2019 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u4e8e\u5317\u4eac\u65f6\u95f4 10 \u6708 7 \u65e5\u4e0b\u5348 5 \u70b9 30 \u5206\u516c\u5e03\uff0c\u4eca\u5e74\u7684\u83b7\u5956\u8005\u6709\u4e09\u4f4d\uff0c\u4ed6 […]<\/p>\n","protected":false},"author":1,"featured_media":125994,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/125993"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=125993"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/125993\/revisions"}],"predecessor-version":[{"id":125999,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/125993\/revisions\/125999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/125994"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=125993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=125993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=125993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}