{"id":128581,"date":"2019-11-26T12:35:18","date_gmt":"2020-04-21T02:35:25","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/128581\/"},"modified":"2020-04-21T10:35:27","modified_gmt":"2020-04-21T02:35:27","slug":"fb619a95c7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/128581\/","title":{"rendered":"\u53c8\u6709\u77e5\u540d\u65e5\u4f01\u63a8\u51fa\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u6280\u672f\uff0c\u8fd9\u4e8b\u513f\u9760\u8c31\u5417\uff1f"},"content":{"rendered":"
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<\/section>\n<\/section>\n
\u8bba\u53ca\u5bf9\u75be\u75c5\u7684\u6050\u60e7\uff0c\u6ca1\u6709\u4ec0\u4e48\u6bd4\u764c\u75c7\u66f4\u80fd\u5524\u8d77\u4eba\u4eec\u7684\u5171\u9e23\u3002\u6628\u65e5\uff0c\u53c8\u6709\u5173\u4e8e\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u7684\u65b0\u95fb\u559c\u63d0\u5fae\u535a\u70ed\u641c\u3002<\/span><\/section>\n


<\/p>\n

\u65e5\u672c\u67d0\u77e5\u540d\u4f01\u4e1a\u5ba3\u5e03\u63a8\u51fa\u300c\u4e00\u6ef4\u8840\u68c0\u6d4b\u65e9\u671f\u764c\u75c7\u300d\u6280\u672f\uff0c\u5e76\u4e14\u516c\u5e03\u4e86\u5b9e\u9a8c\u6570\u636e\u53ca\u7ed3\u679c\uff0c\u5c06\u5728\u660e\u5e74\u6b63\u5f0f\u5f00\u542f\u5b9e\u8bc1\u8bd5\u9a8c\u3002<\/span><\/section>\n


<\/p>\n

\"\u53c8\u6709\u77e5\u540d\u65e5\u4f01\u63a8\u51fa\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u6280\u672f\uff0c\u8fd9\u4e8b\u513f\u9760\u8c31\u5417\uff1f\"<\/span><\/section>\n


<\/p>\n

\u636e\u79f0\uff0c\u8fd9\u4e00\u6280\u672f\u901a\u8fc7\u68c0\u67e5\u5206\u6ccc\u5728\u8840\u6db2\u4e2d\u7684\u5fae\u5c0f RNA\uff08miRNA\uff09\u7684\u79cd\u7c7b\u4e0e\u6d53\u5ea6\uff0c\u6709\u671b\u4ece 1  \u6ef4\u8840\u4e2d\u68c0\u6d4b\u51fa\u5305\u62ec\u80c3\u764c\u3001\u5927\u80a0\u764c\u7b49 13 \u79cd\u764c\u75c7\uff0c\u800c\u4e14\u5728\u68c0\u6d4b\u540e 2 \u4e2a\u5c0f\u65f6\u5185\u5c31\u80fd\u62ff\u5230\u7ed3\u679c\uff0c\u51c6\u786e\u5ea6\u9ad8\u8fbe 99%\uff0c\u82b1\u8d39\u4ec5\u5728 2 \u4e07\u65e5\u5143\u4ee5\u5185\uff08\u7ea6\u5408\u4eba\u6c11\u5e01 1292 \u5143\uff09\u3002<\/span><\/section>\n


<\/p>\n

\u8fd9\u79cd\u53f7\u79f0\u65e0\u521b\u3001\u51c6\u786e\u3001\u7b80\u4fbf\u3001\u4fbf\u5b9c\u7684\u65e9\u8bca\u624b\u6bb5\uff0c\u5145\u5206\u8fce\u5408\u4e86\u4eba\u4eec\u5bf9\u4e8e\u764c\u75c7\u7684\u6050\u60e7\u548c\u65e9\u671f\u53d1\u73b0\u7684\u8bc9\u6c42\u2014\u2014\u76ee\u524d 90% \u7684\u60a3\u8005\u8bca\u65ad\u764c\u75c7\u65f6\u5df2\u7ecf\u5904\u4e8e\u665a\u671f\uff0c\u4e27\u5931\u6839\u6cbb\u624b\u6bb5\uff0c5 \u5e74\u751f\u5b58\u7387\u901a\u5e38\u5728 20% \u4ee5\u4e0b\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/section>\n
\u7136\u800c\uff0c<\/span>\u4e0e\u6d88\u606f\u70ed\u5ea6\u4f34\u968f\u800c\u6765\u7684\u9664\u4e86\u5bf9\u65b0\u6280\u672f\u7684\u671f\u5f85\uff0c\u8fd8\u6709\u542c\u4e86\u592a\u591a\u300c\u6ef4\u8840\u6d4b\u764c\u7248\u300d\u72fc\u6765\u4e86\u6545\u4e8b\u7684\u4e13\u4e1a\u4eba\u58eb\uff0c\u5bf9\u6b64\u63d0\u51fa\u9887\u591a\u8d28\u7591\u3002<\/span><\/section>\n


<\/p>\n

\u8fd9\u9879\u53f7\u79f0\u80fd\u6d4b\u764c\u7684 miRNA \u68c0\u6d4b\u6280\u672f\u5230\u5e95\u662f\u4ec0\u4e48\uff1f\u6709\u4e86\u65e5\u672c\u77e5\u540d\u4f01\u4e1a\u80cc\u4e66\u548c\u65e5\u672c\u4e3b\u6d41\u7535\u89c6\u53f0\u62a5\u9053\uff0c\u5b83\u5230\u5e95\u9760\u4e0d\u9760\u8c31\uff1f\u4ee5\u4e0b\u662f\u5e26\u6765\u7684\u89e3\u8bfb\u3002<\/span><\/strong>
<\/span><\/section>\n


<\/p>\n


<\/p>\n

miRNA \u68c0\u6d4b\u6280\u672f\u662f\u4ec0\u4e48\uff1f<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n
\u9996\u5148\uff0c\u8ba9\u6211\u4eec\u6765\u770b\u770b\u8fd9\u4e00\u6280\u672f\u7684\u6838\u5fc3\u4e3b\u89d2\uff1amiRNA \u68c0\u6d4b\u3002<\/span><\/section>\n

<\/span><\/section>\n
miRNA <\/span>\u662f\u4e00\u7c7b\u8f6c\u5f55\u540e\u53ef\u4ee5\u8c03\u8282\u591a\u79cd\u57fa\u56e0\u8868\u8fbe\u7684\u77ed\u7247\u6bb5\u975e\u7f16\u7801 RNA\u3002\u8fd1\u5e74\u6765\uff0c\u5bf9\u4e8e\u8840\u6d46\u4e2d miRNA \u8868\u8fbe\u6539\u53d8\u548c\u80bf\u7624\u76f8\u5173\u6027\u7684\u7814\u7a76\u8d8a\u6765\u8d8a\u591a\uff0c\u4f8b\u5982\u98df\u7ba1\u764c\u60a3\u8005\u591a\u51fa\u73b0 miR-19a \u7684\u5347\u9ad8\uff0c\u7ed3\u80a0\u764c\u53ef\u51fa\u73b0 miR-15b \u7684\u5347\u9ad8\u7b49\u3002<\/span><\/section>\n

<\/span><\/section>\n
\"\u53c8\u6709\u77e5\u540d\u65e5\u4f01\u63a8\u51fa\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u6280\u672f\uff0c\u8fd9\u4e8b\u513f\u9760\u8c31\u5417\uff1f\"<\/section>\n
miRNA \u7684\u751f\u547d\u8fc7\u7a0b\uff08\u53c2\u8003\u6587\u732e 6\uff09<\/span><\/section>\n

<\/span><\/section>\n
\u90a3\u4e48\uff0c\u68c0\u6d4b miRNA \u7684\u53d8\u5316\u662f\u4e0d\u662f\u5c31\u80fd\u51c6\u786e\u5730\u8bca\u65ad\u80bf\u7624\u5462\uff1f<\/span><\/strong><\/span><\/section>\n

<\/span><\/strong><\/span><\/section>\n
\u5f88\u9057\u61be\uff0c\u73b0\u5728\u4e34\u5e8a\u4e0a\u8fd8\u505a\u4e0d\u5230\u8fd9\u4e00\u70b9\u3002<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n
\u764c\u75c7\u662f\u4e00\u79cd\u591a\u57fa\u56e0\u591a\u56e0\u7d20\u75be\u75c5\uff0c\u76ee\u524d\uff0c\u7279\u5b9a\u57fa\u56e0\u6539\u53d8\u5f15\u8d77\u7684\u764c\u75c7\u53ea\u6709 5\uff5e10%\u3002\u56e0\u6b64\uff0c\u8840\u6d46\u51fa\u73b0 miRNA \u7684\u51fa\u73b0\u53d8\u5316\u4e0d\u4ee3\u8868\u4e00\u5b9a\u60a3\u764c\uff0c\u800c\u764c\u75c7\u60a3\u8005\u4e5f\u4e0d\u4e00\u5b9a\u4f1a\u51fa\u73b0\u7279\u5b9a miRNA \u7684\u6539\u53d8\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5373\u4f7f\u67d0\u4f4d\u60a3\u8005\u68c0\u6d4b miRNA \u786e\u5b9e\u80fd\u591f\u5e2e\u52a9\u8bca\u65ad\u51fa\u4ed6\u7279\u5b9a\u57fa\u56e0\u6539\u53d8\u5f15\u8d77\u7684\u764c\u75c7\uff0c\u53d1\u73b0\u4e86\u4e4b\u540e\u5462\uff1f<\/span><\/section>\n


<\/p>\n

\u8fd9\u9879\u6280\u672f\u7684\u4e00\u4e2a\u5671\u5934\u662f\u300c\u53d1\u73b0 0 \u671f\u8d85\u65e9\u671f\u764c\u75c7\u300d\uff0c\u4e5f\u5c31\u662f\u6240\u8c13\u7684\u5728\u53d1\u73b0\u75c5\u7076\u4e4b\u524d\u8bca\u65ad\u764c\u75c7\u3002<\/span>\u7136\u800c\uff0c\u9664\u4e86\u67d0\u4e9b\u5177\u6709\u7279\u5b9a\u57fa\u56e0\u6539\u53d8\u7684\u764c\u75c7\u6709\u53ef\u80fd\u8fdb\u884c\u533b\u7597\u624b\u6bb5\u9884\u9632\uff0c\u4f8b\u5982\u7f8e\u56fd\u5973\u5f71\u661f\u5b89\u5409\u4e3d\u5a1c\u00b7\u6731\u8389\u643a\u5e26\u6709 BRCA1 \u57fa\u56e0\u7a81\u53d8\uff0c\u60a3\u4e73\u817a\u764c\u51e0\u7387\u9ad8\u8fbe 87%\uff0c\u56e0\u6b64\u505a\u4e86\u9884\u9632\u6027\u4e73\u817a\u5207\u9664\uff0c<\/span>\u5bf9\u4e8e\u5927\u591a\u6570\u5b9e\u4f53\u80bf\u7624\u800c\u8a00\uff0c\u5728\u6ca1\u6709\u786e\u5207\u7684\u75c5\u7076\u90e8\u4f4d\u4e4b\u524d\uff0c\u65e0\u6cd5\u8fdb\u884c\u624b\u672f\u5e72\u9884\u3002<\/strong><\/span><\/section>\n


<\/p>\n

\u6b64\u5916\uff0c\u73b0\u6709\u7684\u764c\u75c7\u8bca\u65ad\u91d1\u6807\u51c6\u662f\u7ec4\u7ec7\u6d3b\u68c0\u75c5\u7406\u3002<\/span>\u9664\u4e86\u786e\u8bca\u764c\u75c7\u5916\uff0c\u7ec4\u7ec7\u75c5\u7406\u8fd8\u80fd\u591f\u505a\u5230\u764c\u75c7\u7684\u5206\u578b\u4e0e\u5206\u671f\uff0c\u6709\u52a9\u4e8e\u4e34\u5e8a\u6cbb\u7597\u51b3\u7b56\u548c\u9884\u540e\u5224\u65ad\uff0c\u800c miRNA \u68c0\u6d4b\u6682\u65f6\u8fd8\u65e0\u6cd5\u5b9e\u73b0\u8fd9\u4e00\u70b9\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u56e0\u6b64\uff0c\u4e0d\u8bba\u5728\u764c\u75c7\u7684\u8bca\u65ad\uff0c\u8fd8\u662f\u5728\u63d0\u4f9b\u6cbb\u7597\u9884\u540e\u4fe1\u606f\u65b9\u9762\uff0c miRNA \u90fd\u4e0d\u80fd\u5b8c\u5168\u66ff\u4ee3\u73b0\u6709\u7684\u7ec4\u7ec7\u5b66\u68c0\u67e5\uff0c\u4ecd\u9700\u8981\u5176\u4ed6\u624b\u6bb5\u8f85\u52a9\u3002<\/span><\/strong><\/section>\n


<\/p>\n


<\/p>\n

\u771f\u7684\u662f\u5c11\u3001\u5feb\u3001\u4f4e\u3001\u9ad8\u5417\uff1f<\/span><\/strong><\/span><\/strong><\/section>\n
<\/strong><\/section>\n


<\/p>\n

\u9664\u4e86 miRNA \u672c\u8eab\u5728\u80bf\u7624\u7814\u7a76\u9886\u57df\u7684\u81ea\u5e26\u70ed\u5ea6\u5916\uff0c\u5ba3\u4f20\u4e2d 1 \u6ef4\u8840\u7684\u5c11\u30012 \u5c0f\u65f6\u7684\u5feb\u30011200 \u5143\u7684\u4f4e\u82b1\u8d39\u4e0e 99% \u9ad8\u51c6\u786e\u6027\u7684\u5bf9\u6bd4\uff0c\u540c\u6837\u4e3a\u8fd9\u4e00\u65b0\u6280\u672f\u63cf\u7ed8\u4e86\u65e0\u9650\u7684\u5546\u4e1a\u524d\u666f\u3002<\/span><\/section>\n


<\/p>\n

\u7136\u800c\uff0c\u8fd9\u4e2a\u5c11\u3001\u5feb\u3001\u4f4e\u3001\u9ad8\u4ecd\u7136\u5177\u6709\u4e00\u4e9b\u8ba8\u8bba\u7a7a\u95f4\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5148\u770b\u7528\u8840\u91cf\u7684\u5c11\u3002<\/span><\/strong><\/span><\/section>\n


<\/p>\n

\u4eba\u4f53\u8840\u6db2\u7531\u7ea2\u7ec6\u80de\u3001\u767d\u7ec6\u80de\u3001\u8840\u5c0f\u677f\u3001\u8840\u6d46\u7b49\u6210\u5206\u7ec4\u6210\u3002\u4e34\u5e8a\u4e0a\u5927\u591a\u662f\u901a\u8fc7\u91c7 2\uff5e3 \u6beb\u5347\u5de6\u53f3\u5168\u8840\u3001\u901a\u8fc7\u5927\u578b\u7684\u68c0\u6d4b\u8bbe\u5907\u6392\u9664\u4e00\u4e9b\u53d8\u5f02\u7cfb\u6570\u540e\uff0c\u68c0\u6d4b\u8840\u6e05\u4e2d\u80bf\u7624\u6807\u5fd7\u7269\u7684\u542b\u91cf\uff0c\u8fdb\u884c\u76f8\u5173\u7684\u8f85\u52a9\u8bca\u65ad\u53ca\u76d1\u6d4b\u80bf\u7624\u75be\u75c5\u3002<\/span><\/section>\n


<\/p>\n

\u76ee\u524d\uff0c\u4e34\u5e8a\u4e0a\u6d89\u53ca\u300c\u6ef4\u8840\u68c0\u67e5\u300d\u6280\u672f\u7684\u4e3b\u8981\u662f\u5e8a\u65c1\u5feb\u901f\u68c0\u6d4b\uff08POCT\uff09\uff0c\u5b83\u5177\u6709\u5c0f\u578b\u5316\u3001\u4fbf\u643a\u3001\u5feb\u901f\u7684\u7279\u5f81\uff0c\u5927\u5bb6\u6240\u719f\u77e5\u7684\u8840\u7cd6\u4eea\u5c5e\u4e8e\u5176\u4e2d\u4e00\u79cd\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u8fd9\u9879\u6280\u672f\u4e2d\uff0c1 \u6ef4\u8840\u80fd\u591f\u8fbe\u5230\u5316\u9a8c\u6240\u9700\u8981\u7684\u6700\u5c0f\u5242\u91cf\u5417\uff1f<\/span>\u5176\u4e2d\u7684\u7a33\u5b9a\u6027\u3001\u53d8\u5f02\u7cfb\u6570\u5982\u4f55\uff1f\u6211\u4eec\u6682\u65f6\u4e0d\u5f97\u800c\u77e5\u3002<\/span><\/span><\/section>\n
<\/section>\n

<\/span><\/section>\n
\u518d\u770b\u68c0\u6d4b\u901f\u5ea6\u7684\u5feb\u3002<\/span><\/strong><\/section>\n


<\/p>\n

\u76ee\u524d\uff0c\u4e34\u5e8a\u5e38\u89c1\u7684\u751f\u5316\u68c0\u67e5\u548c\u80bf\u7624\u6807\u8bb0\u7269\u7b5b\u67e5\u5728\u6280\u672f\u8303\u56f4\u5185\u53ef\u4ee5\u8fbe\u5230 2 \u5c0f\u65f6\u51fa\u7ed3\u679c\u7684\u6548\u679c\uff0c\u53ea\u662f\u8003\u8651\u5230\u533b\u9662\u68c0\u6d4b\u6837\u672c\u91cf\u5927\u7684\u95ee\u9898\uff0c\u4e00\u822c\u4f1a\u9002\u5f53\u7684\u5ef6\u957f\u51fa\u68c0\u67e5\u7ed3\u679c\u7684\u65f6\u95f4\u3002<\/span><\/section>\n


<\/p>\n

\u5176\u6b21\u662f\u82b1\u8d39\u4ef7\u683c\u7684\u4f4e\u3002<\/span><\/strong><\/span><\/section>\n


<\/p>\n

\u6709\u7f51\u53cb\u770b\u5230\u65b0\u95fb\u5f88\u6fc0\u52a8\uff0c\u7559\u8a00\u8868\u793a\u300c\u518d\u4e5f\u4e0d\u9700\u8981\u53bb\u5230\u533b\u9662\u82b1\u51e0\u5343\u505a CT \u68c0\u67e5\u4e86\uff01\u300d\u4f46\u4e8b\u5b9e\u4e0a\uff0c\u5373\u4f7f\u8fd9\u9879\u6280\u672f\u771f\u7684\u628a\u764c\u75c7\u7b5b\u67e5\u51fa\u6765\uff0c\u5982\u679c\u4e0d\u505a CT \u5c31\u4e0d\u77e5\u9053\u764c\u75c7\u7684\u75c5\u75c7\u5728\u4f55\u5904\uff0c\u5c31\u7b97\u8981\u505a\u624b\u672f\u4e5f\u65e0\u4ece\u4e0b\u5200\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u56e0\u6b64\uff0c<\/span>\u6709\u4e86\u8fd9\u6837\u4e00\u4e2a\u8840\u6db2\u68c0\u67e5\u5e76\u4e0d\u610f\u5473\u7740\u53ef\u4ee5\u7701\u7565\u73b0\u6709\u7684\u68c0\u67e5\u8d39\u7528\u3002\u6070\u6070\u76f8\u53cd\uff0c\u8fd9\u662f\u5728\u73b0\u6709\u7684\u68c0\u67e5\u8d39\u7528\u4e4b\u4e0a\u9644\u52a0\u8fd9\u9879\u68c0\u67e5\u7684\u8d39\u7528\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6700\u540e\u770b 99% \u51c6\u786e\u6027\u7684\u9ad8\u3002<\/span><\/strong><\/span><\/section>\n


<\/p>\n

\u4e34\u5e8a\u68c0\u9a8c\u8bca\u65ad\u4e2d\uff0c\u5bf9\u68c0\u67e5\u624b\u6bb5\u7684\u8bc4\u4ef7\u6807\u51c6\u5305\u62ec\u662f\u4e00\u81f4\u6027\u3001\u7075\u654f\u5ea6\uff08\u764c\u75c7\u60a3\u8005\u88ab\u6b63\u786e\u68c0\u67e5\u51fa\u6765\u7684\u6bd4\u4f8b\uff09\u4ee5\u53ca\u7279\u5f02\u6027\uff08\u975e\u764c\u75c7\u60a3\u8005\u88ab\u68c0\u6d4b\u51fa\u9634\u6027\u7684\u6bd4\u4f8b\uff09\u3002<\/span><\/section>\n


<\/p>\n

99% \u51c6\u786e\u7387\u7684\u8868\u8ff0\u5e76\u4e0d\u5c5e\u4e8e\u4e13\u4e1a\u7528\u8bed\uff0c\u6307\u4ee3\u7684\u5230\u5e95\u662f\u7075\u654f\u5ea6<\/span>\u8fd8\u662f\u7279\u5f02\u6027\uff1f\u7ed3\u8bba\u5e76\u4e0d\u6e05\u6670\uff0c\u6ef4\u8840\u6d4b\u764c\u771f\u6b63\u7684\u51c6\u786e\u5ea6\u4ecd\u7136\u672a\u77e5\u3002<\/span><\/span><\/strong><\/span><\/section>\n
<\/section>\n


<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u4e0d\u540c\u75be\u75c5\u51fa\u73b0\u540c\u4e00\u79cd\u7279\u5b9a miRNA \u53d8\u5316\u7684\u73b0\u8c61\u975e\u5e38\u5e38\u89c1\uff0c\u56e0\u6b64\u8fd9\u4e9b miRNA \u8bca\u65ad\u7684\u7279\u5f02\u6027\u5e76\u4e0d\u4ee4\u4eba\u6ee1\u610f\u3002<\/span>
<\/section>\n


<\/p>\n

\u4f8b\u5982 miR-21 \u5728\u80ba\u764c\uff0c\u524d\u5217\u817a\u764c\uff0c\u4e73\u817a\u764c\u7b49\u591a\u79cd\u764c\u75c7\u4e2d\u90fd\u6709\u8fc7\u8868\u8fbe\uff0c\u800c miR-27a \u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u8fc7\u8868\u8fbe\uff0c\u4f46\u662f\u5728\u6025\u6027\u80ba\u6813\u585e\uff0c\u827e\u6ecb\u75c5\u7b49\u75be\u75c5\u4e2d\u540c\u6837\u8868\u8fbe\u5347\u9ad8\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5c3d\u7ba1\u8054\u5408\u591a\u79cd miRNA \u53ef\u4f7f\u764c\u75c7\u8bca\u65ad\u7684\u51c6\u786e\u6027\u5347\u9ad8\uff0c\u4f8b\u5982\u5728\u80ba\u764c\u4e2d\uff0c\u8054\u5408\u4f7f\u7528 miR-126\uff0cmiR-145\uff0cmiR-210 \u548c miR-205-5p \u53ef\u4ee5\u4f7f\u8bca\u65ad\u7684\u654f\u611f\u6027\u8fbe\u5230 91%\uff0c\u7279\u5f02\u6027\u8fbe\u5230 96%\uff0c\u4f46\u4f9d\u65e7\u5b58\u5728\u5047\u9634\u6027\u548c\u5047\u9633\u6027\u53ef\u80fd\u3002<\/span><\/section>\n

<\/span><\/section>\n

<\/span><\/strong><\/span><\/section>\n
\u8fd9\u6b21\u4f1a\u662f\u72fc\u6765\u4e86\u7684\u6545\u4e8b\u5417\uff1f<\/strong><\/span><\/strong><\/span><\/section>\n


<\/p>\n

\u8bf4\u4e86\u8fd9\u4e48\u591a\uff0c\u662f\u4e0d\u662f\u610f\u5473\u7740 miRNA \u68c0\u6d4b\u8fd9\u9879\u6280\u672f\u5c31\u5b8c\u5168\u6ca1\u6709\u7528\u5904\u5462\uff1f<\/span><\/strong>\u5e76\u4e0d\u662f\u8fd9\u6837\u7684\u3002<\/span><\/strong><\/span><\/section>\n


<\/p>\n

\u5faa\u73af miRNA \u786e\u5b9e\u53ef\u4ee5\u52a8\u6001\u5730\u53cd\u6620\u80bf\u7624\u53d8\u5316\u3002\u5bf9\u4e8e\u5df2\u7ecf\u786e\u8bca\u80bf\u7624\u7684\u60a3\u8005\uff0cmiRNA \u7684\u53d8\u5316\u53ef\u80fd\u6709\u52a9\u4e8e\u9884\u6d4b\u6cbb\u7597\u6548\u679c\uff0c\u68c0\u6d4b\u836f\u7269\u654f\u611f\u6027\u548c\u76d1\u6d4b\u80bf\u7624\u590d\u53d1\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5f53\u7136\uff0c\u8fd9\u79cd\u7528\u9014\u4e5f\u4ec5\u4ec5\u662f\u5728\u4e00\u4e9b\u5c0f\u578b\u5b9e\u9a8c\u4e2d\u5f97\u4ee5\u53d1\u73b0\uff0c\u5e76\u6ca1\u6709\u5199\u5165\u6b63\u89c4\u7684\u764c\u75c7\u8bca\u7597\u6307\u5357\uff0c\u8fd8\u9700\u8981\u66f4\u591a\u8bc1\u636e\u6765\u9a8c\u8bc1\u3002<\/span>miRNA \u7528\u4e8e\u764c\u75c7\u7684\u65e9\u671f\u8bca\u65ad\u4e5f\u8fd8\u6709\u957f\u957f\u7684\u8def\u8981\u8d70\uff0c\u8fd8\u9700\u8981\u66f4\u591a\u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9a8c\u8bc1\u624d\u80fd\u53d1\u73b0\u764c\u75c7\u65e9\u671f\u8bca\u65ad\u66f4\u7406\u60f3\u7684\u6807\u5fd7\u7269\u3002<\/span><\/section>\n
<\/section>\n


<\/p>\n

<\/section>\n
\u8be5\u77e5\u540d\u516c\u53f8\u4e5f\u8868\u793a\uff0c\u7814\u7a76\u7684\u5177\u4f53\u60c5\u51b5\u5c06\u4e8e 12 \u6708 3\uff5e8 \u65e5\u5728\u65e5\u672c\u798f\u5188\u53ec\u5f00\u7684\u300c\u7b2c 42 \u5c4a\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\u300d\u4e0a\u53d1\u8868\u3002\u81ea 2020 \u5e74\u8d77\uff0c\u7531\u4e1c\u4eac\u533b\u79d1\u5927\u5b66\u53ca\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u4e5f\u5c06\u5171\u540c\u53c2\u4e0e\u7814\u7a76\uff0c\u542f\u52a8\u5b9e\u8bc1\u8bd5\u9a8c\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u4e00\u76f4\u90fd\u662f\u72fc\u6765\u4e86\u6545\u4e8b\u7684\u9ad8\u53d1\u533a\uff0c\u6700\u6709\u540d\u7684\u5f53\u5c5e\u6b64\u524d\u81ed\u540d\u662d\u8457\u7684\u5973\u7248\u4e54\u5e03\u65af\u4f0a\u4e3d\u838e\u767d \u00b7 \u970d\u59c6\u65af\u7684\u9ad8\u8fbe 90 \u4ebf\u7f8e\u5143\u7684\u60ca\u5929\u9a97\u5c40\uff0c\u800c\u9a97\u5c40\u7684\u4e2d\u5fc3\u6b63\u662f\u4e00\u6b3e<\/span>\u4fbf\u643a\u8840\u6db2\u68c0\u6d4b\u4eea\uff0c<\/span>\u5b83\u5ba3\u79f0\u53ea\u8981\u4ece\u6307\u5c16\u91c7 10ml \u6216\u8005\u66f4\u5c11\u7684\u8840\u6db2\u5c31\u80fd\u5feb\u901f\u5b8c\u6210 240 \u9879\u8840\u6db2\u5b66\u68c0\u67e5\u3002\u4f46\u6700\u7ec8\u9a97\u5c40\u88ab\u62c6\u7a7f\uff0c\u8d85\u8fc7 100 \u4e07\u6b21\u8ba1\u8840\u6db2\u68c0\u6d4b\u7ed3\u679c\u88ab\u8bc1\u5b9e\u4e3a\u65e0\u6548\u3001\u865a\u5047\u6570\u636e\u3002<\/span><\/section>\n

<\/span><\/section>\n

\"\u53c8\u6709\u77e5\u540d\u65e5\u4f01\u63a8\u51fa\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u6280\u672f\uff0c\u8fd9\u4e8b\u513f\u9760\u8c31\u5417\uff1f\"<\/p>\n


<\/p>\n

\u4f0a\u4e3d\u838e\u767d \u00b7 \u970d\u59c6\u65af\u516c\u53f8\u63a8\u51fa\u7684\u9a97\u5b50\u4ea7\u54c1\uff0c\u53f7\u79f0\u80fd\u4ee3\u66ff\u73b0\u6709\u5927\u578b\u8bbe\u5907\u7684\u4fbf\u643a\u8840\u6db2\u68c0\u6d4b\u4eea<\/span>\uff08<\/span>\u56fe\u6e90<\/span>\uff1a<\/span>T<\/span>heranos \u2013 Silicon Valley\u2019s Greatest Disaster\uff09<\/span><\/p>\n


<\/span><\/section>\n
\u8fd9\u4e00\u6b21\uff0c\u72fc\u6765\u4e86\u7684\u6545\u4e8b\u8fd8\u4f1a\u91cd\u6f14\u5417\uff1f\u53ea\u80fd\u8bf4\uff0c\u662f\u9aa1\u5b50\u662f\u9a6c\u8fd8\u8981\u62ff\u51fa\u6765\u6e9c\u6e9c\uff0c\u7b49\u5230\u5b9e\u8bc1\u8bd5\u9a8c\u7ed3\u679c\u51fa\u6765\u540e\uff0c\u4e5f\u8bb8\u7b54\u6848\u4e5f\u5c31\u6e05\u6670\u4e86\u3002<\/span><\/strong><\/span><\/section>\n

<\/span><\/strong><\/span><\/section>\n

<\/span><\/strong><\/span><\/section>\n
\u5173\u4e8e\u764c\u75c7\u7b5b\u67e5\uff0c\u4f60\u9700\u8981\u77e5\u9053\u8fd9\u4e9b<\/strong><\/span><\/section>\n


<\/p>\n

\u6700\u540e\uff0c\u65e2\u7136\u76ee\u524d miRNA \u68c0\u6d4b\u65e0\u6cd5\u66ff\u4ee3\u73b0\u6709\u7684\u7ec4\u7ec7\u5b66\u68c0\u67e5\u624b\u6bb5\uff0c\u6211\u4eec\u5e94\u8be5\u600e\u6837\u8fdb\u884c\u6b63\u89c4\u3001\u9760\u8c31\u7684\u764c\u75c7\u7b5b\u67e5\uff1f<\/span><\/section>\n


<\/p>\n

\u6839\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u9884\u9632\u4e2d\u5fc3\u63a8\u8350\u9075\u5faa\u7f8e\u56fd\u9884\u9632\u533b\u5b66\u5de5\u4f5c\u7ec4<\/span>\uff08U.S. Preventive Services Task Force\uff09<\/span>\u5236\u5b9a\u6307\u5357\uff0c\u4ee5\u4e0b 4 \u79cd\u764c\u75c7\uff08\u4e73\u817a\u764c\u3001\u5bab\u9888\u764c\u3001\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\uff09\u6709\u660e\u786e\u7b5b\u67e5\u6307\u5357\u3002<\/span><\/section>\n


<\/p>\n

1. \u4e73\u817a\u764c<\/strong><\/strong><\/span><\/strong><\/strong>
<\/span><\/section>\n


<\/p>\n

\u30fb\u9002\u7528\u4eba\u7fa4<\/span><\/section>\n


<\/p>\n

\n
\n
\n
50 \u5c81\u5230 74 \u5c81\u7684\u6709\u666e\u901a\u98ce\u9669\u7684\u5973\u6027\uff0c\u6bcf 2 \u5e74\u505a\u4e00\u6b21\u4e73\u623f X \u7ebf\u9020\u5f71\u68c0\u67e5\u3002<\/span><\/section>\n


<\/p>\n

40 \u5c81\u5230 49 \u5c81\u7684\u5973\u6027\u5efa\u8bae\u8ddf\u533b\u751f\u5171\u540c\u8ba8\u8bba\uff0c\u8003\u8651\u75c5\u4eba\u7684\u5bb6\u65cf\u53f2\u3001\u4e2a\u4eba\u98ce\u9669\u3001\u6743\u8861\u5229\u5f0a\u540e\u4e00\u8d77\u505a\u51b3\u5b9a\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n
<\/section>\n
\u30fb\u7b5b\u67e5\u624b\u6bb5<\/span><\/section>\n


<\/p>\n

\n
\n
\n
X \u7ebf\u94bc\u9776\u9020\u5f71\uff08mammography\uff09\uff1a\u7814\u7a76\u5df2\u8bc1\u660e\u5e38\u89c4\u7684 X \u7ebf\u9020\u5f71\u53ef\u4ee5\u964d\u4f4e\u6b7b\u4e8e\u4e73\u817a\u764c\u7684\u98ce\u9669\u3002<\/span><\/section>\n


<\/p>\n

\u6838\u78c1\u5171\u632f\uff08MRI\uff09\uff1a\u4e00\u822c\u4f5c\u4e3a X \u7ebf\u6216\u67e5\u4f53\u53d1\u73b0\u5f02\u5e38\u7684\u8865\u5145\u68c0\u67e5\u624b\u6bb5\u3002\u56e0\u4e3a\u6709\u65f6 MRI \u5b58\u5728\u5047\u9633\u6027\u53ef\u80fd\uff0c\u6240\u4ee5\u53ea\u9002\u7528\u4e8e\u9ad8\u98ce\u9669\u7684\u4eba\u7fa4\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n
2. \u5bab\u9888\u764c<\/strong><\/strong><\/span><\/section>\n


<\/p>\n

\u30fb\u9002\u7528\u4eba\u7fa4<\/span><\/section>\n


<\/p>\n

\n
\n
\n
21\uff5e29 \u5c81\u5973\u6027\uff0c\u5efa\u8bae\u6bcf 3 \u5e74\u8fdb\u884c\u4e00\u6b21\u5bab\u9888\u764c\u7b5b\u67e5\uff0c\u53ea\u8fdb\u884c\u5df4\u6c0f\u6d82\u7247\u3002<\/span><\/section>\n


<\/p>\n

30\uff5e65 \u5c81\u5973\u6027\uff0c\u5efa\u8bae\u6bcf 3 \u5e74\u8fdb\u884c\u4e00\u6b21\u5bab\u9888\u7ec6\u80de\u5b66\u5355\u72ec\u7b5b\u67e5\uff0c\u6216\u6bcf 5 \u5e74\u8fdb\u884c\u4e00\u6b21\u9ad8\u5371\u578b\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\uff08hrHPV\uff09\u68c0\u6d4b\u5355\u72ec\u7b5b\u67e5\uff0c\u6216\u6bcf 5 \u5e74\u8fdb\u884c\u4e00\u6b21 hrHPV \u68c0\u6d4b\u8054\u5408\u7ec6\u80de\u5b66\u68c0\u6d4b\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/section>\n
\u30fb\u7b5b\u67e5\u624b\u6bb5<\/span>
<\/section>\n


<\/p>\n

\n
\n
\n
\u5bab\u9888\u6d82\u7247\uff08Pap smear\uff09\u548c HPV \u68c0\u6d4b\u3002\u8fd9 2 \u9879\u7b5b\u67e5\u53ef\u4ee5\u6709\u6548\u5730\u53d1\u73b0\u65e9\u671f\u75c5\u53d8\uff0c\u53ca\u65f6\u5e72\u9884\uff0c\u963b\u65ad\u764c\u75c7\u7684\u53d1\u5c55\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

3. \u80ba\u764c<\/strong><\/strong><\/span><\/section>\n


<\/p>\n

\u30fb\u9002\u7528\u4eba\u7fa4<\/span><\/section>\n


<\/p>\n

\n
\n
\n
\u540c\u65f6\u6ee1\u8db3\u4ee5\u4e0b 3 \u70b9\uff1a\u91cd\u5ea6\u5438\u70df\u53f2\uff08\u6709\u5177\u4f53\u6807\u51c6\uff09\u3001\u73b0\u5728\u4ecd\u5728\u5438\u70df\u6216\u8005\u662f\u5728\u8fc7\u53bb 15 \u5e74\u5185\u6212\u70df\u300155 \u5c81\u5230 80 \u5c81\u4e4b\u95f4\u3002<\/span><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n
<\/section>\n
\u30fb\u7b5b\u67e5\u624b\u6bb5\uff1a<\/span><\/section>\n


<\/p>\n

\n
\n
\n
\u4f4e\u5242\u91cf\u87ba\u65cb CT<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u7b5b\u67e5\u53ef\u80fd\u4f1a\u6709\u5047\u9633\u6027\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e00\u4e2a\u672c\u8eab\u5e76\u6ca1\u6709\u764c\u75c7\u7684\u4eba\u88ab\u8bca\u65ad\u4e3a\u60a3\u6709\u764c\u75c7\uff0c\u6709\u53ef\u80fd\u5f15\u8d77\u8fc7\u5ea6\u8bca\u65ad\u8fdb\u800c\u5bfc\u81f4\u8fc7\u5ea6\u6cbb\u7597\uff0c\u91cd\u590d\u591a\u6b21\u7684\u4f4e\u5242\u91cf CT \u6709\u53ef\u80fd\u5bfc\u81f4\u5065\u5eb7\u4eba\u60a3\u764c\uff0c\u56e0\u6b64\u80ba\u764c\u7684\u7b5b\u67e5\u6709\u66f4\u4e3a\u4e25\u683c\u7684\u63a7\u5236\u3002<\/span><\/section>\n


<\/p>\n

\u6700\u597d\u7684\u964d\u4f4e\u80ba\u764c\u98ce\u9669\u7684\u65b9\u6cd5\u4e0d\u662f\u7b5b\u67e5\uff0c\u800c\u662f\u6212\u70df\u5e76\u4e14\u907f\u514d\u4e8c\u624b\u70df\u3002\u80ba\u764c\u7b5b\u67e5\u7edd\u5bf9\u4e0d\u80fd\u4ee3\u66ff\u6212\u70df\u3002\u7f8e\u56fd\u80ba\u764c\u6b7b\u4ea1\u7387\u7684\u4e0b\u964d\uff0c\u8ddf 60 \u5e74\u4ee3\u5f00\u59cb\u7684\u63a7\u70df\u8fd0\u52a8\u3001\u516c\u5f00\u573a\u5408\u5168\u9762\u7981\u70df\u3001\u63d0\u9ad8\u70df\u8349\u7a0e\u7b49\u52aa\u529b\u5bc6\u5207\u76f8\u5173\u3002<\/span><\/section>\n


<\/p>\n

4. \u7ed3\u76f4\u80a0\u764c<\/strong><\/span><\/section>\n


<\/p>\n

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<\/p>\n

\u30fb\u9002\u7528\u4eba\u7fa4<\/span><\/section>\n


<\/p>\n

\n
\n
\n
\u5e38\u89c4\u7b5b\u67e5\u4ece 50 \u5c81\u5f00\u59cb\uff0c\u4e0d\u5206\u7537\u5973\u3002\u7b5b\u67e5\u5bf9\u9884\u9632\u7ed3\u80a0\u764c\u81f3\u5173\u91cd\u8981\u3002\u63a8\u8350\u6240\u6709 50\uff5e75 \u5c81\u7684\u4eba\u7fa4\u63a5\u53d7\u7b5b\u67e5\u300276\uff5e85 \u5c81\u9700\u8981\u8ddf\u81ea\u5df1\u7684\u533b\u751f\u5546\u91cf\u5171\u540c\u8fdb\u884c\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u4ee5\u4e0b\u4eba\u7fa4\u5efa\u8bae\u5728 50 \u5c81\u4e4b\u524d\u5c31\u5f00\u59cb\u7b5b\u67e5\uff1a<\/span>
<\/section>\n


<\/p>\n

\n
\n
\n
1. \u81ea\u5df1\u6216\u8005\u76f4\u7cfb\u4eb2\u5c5e\u6709\u8fc7\u606f\u8089\u6216\u8005\u662f\u7ed3\u80a0\u764c<\/span><\/section>\n


<\/p>\n

2. \u60a3\u6709\u708e\u6027\u80a0\u9053\u75be\u75c5\uff0c\u6bd4\u5982\u8bf4\u6e83\u75a1\u6027\u80a0\u708e\u6216\u8005\u514b\u7f57\u6c0f\u80a0\u708e<\/span><\/section>\n


<\/p>\n

3. \u60a3\u6709 APC\uff08\u5bb6\u65cf\u6027\u7ed3\u80a0\u606f\u8089\u75c5\u57fa\u56e0\uff09\u6216 HNPCC \u7efc\u5408\u5f81\uff08\u9057\u4f20\u6027\u975e\u606f\u8089\u75c5\u6027\u7ed3\u76f4\u80a0\u764c\uff09<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u30fb\u7b5b\u67e5\u624b\u6bb5<\/span><\/section>\n


<\/p>\n

\n
\n
\n
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<\/section>\n


<\/p>\n

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<\/p>\n

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<\/p>\n


<\/p>\n

\u611f\u8c22\u5929\u6d25\u533b\u79d1\u5927\u5b66\u603b\u533b\u9662\u526f\u4e3b\u4efb\u533b\u5e08 \u80bf\u7624\u5b66\u535a\u58eb \u90b5\u5b9c\uff0c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u533b\u5b66\u9662\u526f\u6559\u6388 \u5f20\u6d2a\u6d9b <\/strong>\u5bf9\u672c\u6587\u7684\u6307\u5bfc\u4e0e\u8d21\u732e<\/span><\/strong><\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\u5bf9\u4e8e\u8fd9\u9879\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u7684\u65b0\u6280\u672f<\/span><\/section>\n
\u4f60\u600e\u4e48\u770b\uff1f<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n

\"\u53c8\u6709\u77e5\u540d\u65e5\u4f01\u63a8\u51fa\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u6280\u672f\uff0c\u8fd9\u4e8b\u513f\u9760\u8c31\u5417\uff1f\"<\/section>\n


<\/p>\n

\u9898\u56fe\u6765\u6e90\uff1a\u7ad9\u9177\u6d77\u6d1b
<\/span><\/section>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

1. https:\/\/www.japantimes.co.jp\/news\/2019\/11\/25\/business\/corporate-business\/toshiba-test-cancer-blood<\/span><\/p>\n

2. Dursco A et al. MicroRNAs and Cancer: A Long Story for Short RNAs. Adv Cancer Res. 2017;135:1-24.<\/span><\/p>\n

3. Bahreyni A et al. Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective. J Physiol. 2019 Jun;234(6):8075-8081.<\/span><\/p>\n

4. Bai Y et al. Plasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis. Biomark Med. 2017 May;11(5):431-441. <\/span><\/p>\n

5. Leng Q et al. A plasma miRNA signature for lung cancer early detection. Oncotarget. 2017<\/span><\/p>\n

6. Nelson KM et al. MicroRNAs and cancer: past, present, and potential future. Mol Cancer Ther. 2008 Dec;7(12):3655-60.<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u8bba\u53ca\u5bf9\u75be\u75c5\u7684\u6050\u60e7\uff0c\u6ca1\u6709\u4ec0\u4e48\u6bd4\u764c\u75c7\u66f4\u80fd\u5524\u8d77\u4eba\u4eec\u7684\u5171\u9e23\u3002\u6628\u65e5\uff0c\u53c8\u6709\u5173\u4e8e\u300c\u6ef4\u8840\u6d4b\u764c\u300d\u7684\u65b0\u95fb\u559c\u63d0\u5fae\u535a\u70ed\u641c\u3002 \u65e5\u672c\u67d0\u77e5\u540d […]<\/p>\n","protected":false},"author":1,"featured_media":128582,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/128581"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=128581"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/128581\/revisions"}],"predecessor-version":[{"id":128588,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/128581\/revisions\/128588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/128582"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=128581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=128581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=128581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}