{"id":12975,"date":"2018-07-23T01:00:00","date_gmt":"2018-07-30T04:13:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/30\/%e4%bb%8easco%e4%bc%9a%e8%ae%ae%e7%9c%8b%e6%8a%97%e8%82%bf%e7%98%a4%e4%b8%aa%e6%80%a7%e5%8c%96%e8%8d%af%e7%89%a9%e7%9a%84%e7%a0%94%e5%8f%91%e8%bf%9b%e5%b1%95\/"},"modified":"2018-07-30T12:13:56","modified_gmt":"2018-07-30T04:13:56","slug":"%e4%bb%8easco%e4%bc%9a%e8%ae%ae%e7%9c%8b%e6%8a%97%e8%82%bf%e7%98%a4%e4%b8%aa%e6%80%a7%e5%8c%96%e8%8d%af%e7%89%a9%e7%9a%84%e7%a0%94%e5%8f%91%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/12975\/","title":{"rendered":"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_editor\">\n<section style=\"padding: 10px;box-sizing: border-box;\">\n<section style=\"border-style: solid;border-width: 2px;border-color: #7dbfe3;padding-bottom: 3px;background-image: repeating-linear-gradient(-45deg, transparent, transparent 1px, #fefefe 1.5px, #fefefe 7px);background-color: #7dbfe3;box-sizing: border-box;\">\n<section style=\"border-width: 2px;border-style: solid;border-color: #7dbfe3;padding: 5px 10px;background-color: #ffffff;margin-left: -3px;margin-top: -10px;margin-left: 3px;box-sizing: border-box;\">\n<section style=\"width: 100%;padding-top: 5px;box-sizing: border-box;\" >\n<section style=\"text-align: justify;\">\n<section style=\"display: inline-block;width: 12px;height: 12px;border-radius: 100%;background: #4467e6;border-width: 2px;border-style: solid;border-color: #7dbfe3;box-sizing: border-box;\"><\/section>\n<p><span style=\"font-family: \u6977\u4f53, \u6977\u4f53_GB2312, SimKai;text-indent: 28px;letter-spacing: 1.5px;font-size: 14px;\">\u5bfc\u8bfb\uff1a2018\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO\uff09\u4f5c\u4e3a\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u76db\u4f1a\uff0c\u5438\u5f15\u4e86\u5168\u7403\u5404\u5927\u79d1\u7814\u673a\u6784\u3001\u6295\u8d44\u673a\u6784\u3001\u5236\u836f\u516c\u53f8\u4ee5\u53ca\u751f\u7269\u6280\u672f\u516c\u53f8\u7684\u76ee\u5149\u3002\u4eca\u5e74\u7684ASCO\u4f1a\u8bae\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u4e73\u817a\u764c\u3001\u6d88\u5316\u9053\u764c\u75c7\u3001\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u764c\u75c7\u4ee5\u53ca\u8840\u6db2\u80bf\u7624\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\u7b49\u591a\u4e2a\u65b9\u9762\u5448\u73b0\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u6210\u679c\uff0c\u5c24\u5176\u662f\u5728\u7cbe\u51c6\u836f\u7269\u7684\u7814\u53d1\u4e0a\u53d6\u5f97\u4e86\u8bf8\u591a\u7a81\u7834\u3002\u672c\u6587\u5c06\u5bf92018\u5e74ASCO\u4f1a\u8bae\u4e2d\u7684\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\u8fdb\u884c\u68b3\u7406\uff0c\u4e3a\u79d1\u7814\u4eba\u5458\u63d0\u4f9b\u53c2\u8003\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;justify-content: flex-start;\">\n<section style=\"width: 8px;height: 5px;border-left: 2px solid #7dbfe3;background-color: #fefefe;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;text-indent: 2em;\">2018\u5e746\u6708\uff0c\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u4f1a\u8bae\u5728\u7f8e\u56fd\u829d\u52a0\u54e5\u53ec\u5f00\u3002\u672c\u5c4a\u5927\u4f1a\u7684\u4e3b\u9898\u662f\u201cDelivering Discoveries: Expanding the Reach of Precision Medicine\u201d(\u521b\u65b0\u9a71\u52a8\uff1a\u4f7f\u7cbe\u51c6\u533b\u5b66\u89e6\u624b\u53ef\u53ca)\uff0c\u5168\u7403\u8d85\u8fc739000\u540d\u80bf\u7624\u5b66\u4e13\u5bb6\u5b66\u8005\u4e0e\u4f1a\u3002\u4f1a\u8bae\u4e13\u9898\u8bbe\u7f6e\u4ee5\u8fdb\u4e00\u6b65\u6269\u5927\u7cbe\u51c6\u533b\u5b66\u6218\u679c\u4e3a\u6838\u5fc3\uff0c\u5185\u5bb9\u6db5\u76d6\u80bf\u7624\u9884\u9632\u3001\u8bca\u65ad\u3001\u6cbb\u7597\u548c\u9884\u540e\u7b49\u591a\u4e2a\u65b9\u9762\u3002\u5e74\u4f1a\u67092500\u591a\u7bc7\u5165\u9009\u6458\u8981\u4ee5\u53e3\u5934\u62a5\u544a\u6216\u58c1\u62a5\u5f62\u5f0f\u5c55\u793a\uff0c\u8fd8\u6709\u8d85\u8fc73350\u7bc7\u6458\u8981\u4ee5\u7535\u5b50\u7248\u5f62\u5f0f\u5728\u7ebf\u53d1\u8868\u3002\u7cbe\u51c6\u533b\u7597\u5df2\u7ecf\u9010\u6e10\u6210\u4e3a\u76ee\u524d\u80bf\u7624\u6cbb\u7597\u7684\u4e3b\u65cb\u5f8b\uff0c\u76f8\u8f83\u4e8e\u65e0\u9009\u62e9\u6027\u7684\u5316\u7597\uff0c\u9776\u5411\u7597\u6cd5\u548c\u514d\u75ab\u7597\u6cd5\u7684\u663e\u793a\u51fa\u5de8\u5927\u4f18\u52bf\uff0c\u7cbe\u51c6\u836f\u7269\u7684\u4e34\u5e8a\u8fdb\u5c55\u65e0\u5f02\u4e8e\u672c\u5c4a\u5927\u4f1a\u7684\u6700\u5927\u770b\u70b9\u30022017\u5e74\u66fe\u51ed\u501fTRK\uff08\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff09\u6291\u5236\u5242larotrectinib\u5728\u591a\u79cdTRK\u53d8\u5f02\u5b9e\u4f53\u80bf\u7624\u4ea7\u751f\u9ad8\u5e94\u7b54\u7387\u7684Loxo Oncology\u516c\u53f8\uff0c\u5728\u4eca\u5e74\u7684ASCO\u4f1a\u8bae\u4e0a\u53c8\u51ed\u501fRET\u6291\u5236\u5242LOXO-292\u7684\u4f18\u5f02\u4e34\u5e8a\u8868\u73b0\u518d\u6b21\u60ca\u8273\u56db\u5ea7\u3002PD-(L)1\u6291\u5236\u5242\u4f5c\u4e3a\u8fd1\u5e74\u6765\u7099\u624b\u53ef\u70ed\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u4f9d\u7136\u662f\u672c\u5c4aASCO\u4f1a\u8bae\u7684\u91cd\u5934\u620f\uff0c\u8054\u5408\u7528\u836f\u6210\u4e3a\u514d\u75ab\u6cbb\u7597\u7684\u7814\u53d1\u8d8b\u52bf\u3002PD-(L)1\u6291\u5236\u5242\u9886\u57df\u7684\u7ade\u4e89\u5df2\u7ecf\u8fdb\u5165\u767d\u70ed\u5316\uff0c\u5df2\u7ecf\u88abFDA\u6279\u51c6\u4e0a\u5e02\u76845\u4e2a\u4ea7\u54c1\u90fd\u5728\u79ef\u6781\u6269\u5c55\u9002\u5e94\u75c7\uff0c\u9ed8\u6c99\u4e1c\u51ed\u501f\u738b\u724c\u836f\u7269Keytruda\uff08pembrolizumab\uff09\u7684\u4e0d\u4fd7\u8868\u73b0\uff0c\u5de9\u56fa\u4e86\u5176\u5728\u80ba\u764c\u6cbb\u7597\u9886\u57df\u7684\u7edd\u5bf9\u9886\u5148\u5730\u4f4d\u3002\u9664\u6b64\u4e4b\u5916\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u3001ALK\uff08\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff09\u6291\u5236\u5242\u3001PARP\uff08\u805a\u817a\u82f7\u4e8c\u78f7\u9178\u6838\u7cd6\u805a\u5408\u9176\uff09\u6291\u5236\u5242\u7b49\u591a\u79cd\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\u90fd\u53d6\u5f97\u4e86\u7a81\u51fa\u8fdb\u5c55\u3002<br  \/><\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532924032.png\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -28px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: #c5e3d3;padding: 2px 14px;border-style: solid;border-width: 3px;border-radius: 0px;border-color: #ffffff;box-sizing: border-box;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #557d62;padding-right: 5px;padding-left: 5px;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"color: rgb(0, 0, 0);font-family: sans-serif;text-align: justify;text-indent: 28px;white-space: normal;\">RET\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\"><strong>LOXO-292<\/strong><\/span><br  \/><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">LOXO-292\u662f\u4e00\u6b3eRET\u6291\u5236\u5242\uff0c\u7531Loxo Oncology\u516c\u53f8\u7814\u53d1\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u2160\u671f\u7814\u7a76\u9636\u6bb5\u3002RET\uff08RET proto-oncogene\uff09\u662f\u4e00\u4e2a\u539f\u764c\u57fa\u56e0\uff0c\u4f4d\u4e8e10\u53f7\u67d3\u8272\u4f53\u3002RET\u57fa\u56e0\u6240\u7f16\u7801\u7684RET\u86cb\u767d\u662f\u4e00\u79cd\u5b58\u5728\u4e8e\u7ec6\u80de\u819c\u4e0a\u7684\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5c5e\u4e8e\u9499\u9ecf\u86cb\u767d\u8d85\u5bb6\u65cf\u6210\u5458\u3002RET\u57fa\u56e0\u7a81\u53d8\u53ca\u878d\u5408\u4e0e\u80bf\u7624\u7684\u53d1\u751f\u53d1\u5c55\u5173\u7cfb\u5bc6\u5207\uff0cRET\u53d8\u5f02\u5728\u764c\u75c7\u4e2d\u5e76\u4e0d\u7b97\u7f55\u89c1\u3002\u4ee5\u878d\u5408\u53d8\u5f02\u4e3a\u4f8b\uff0c\u5b83\u5360NSCLC\u76842%\uff0c\u4e5f\u5360\u7532\u72b6\u817a\u764c\u768410%~20%\u3002\u800c\u5176\u5f02\u5e38\u6fc0\u6d3b\u53d8\u5f02\u5219\u5b58\u5728\u4e8e\u7ea660%\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\u4e2d\u3002LOXO-292\u5c31\u662f\u4e00\u6b3e\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u7684RET\u6291\u5236\u5242\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">Loxo Oncology\u662f\u8fd1\u5e74\u6765\u5174\u8d77\u7684\u4e13\u6ce8\u4e8e\u7cbe\u51c6\u836f\u7269\u7814\u53d1\u7684\u4ee3\u8868\u6027\u516c\u53f8\u3002\u4eca\u5e74\u7684ASCO\u4f1a\u8bae\u4e0a\uff0cLoxo\u516c\u5e03\u4e86\u5176\u521b\u65b0\u7cbe\u51c6\u7597\u6cd5LOXO-292\u7684\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\uff08LIBRETTO-001\uff09\u7ed3\u679c\uff0c\u8be5\u5728\u7814\u836f\u7269\u5728\u5e26\u6709RET\u878d\u5408\u53d8\u5f02\u7684\u60a3\u8005\u4e2d\uff0c\u53d6\u5f97\u4e8677%\u7684\u603b\u4f53\u7f13\u89e3\u7387\u3002\u5728NSCLC\u60a3\u8005\u7ec4\u4e2d\uff0c\u5176\u603b\u4f53\u7f13\u89e3\u7387\u540c\u6837\u4e3a77%\u3002\u800c\u5728RET\u53d8\u5f02\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\u4e2d\uff0c\u8fd9\u6b3e\u5728\u7814\u65b0\u836f\u7684\u603b\u4f53\u7f13\u89e3\u7387\u4e3a45%\u3002\u800c\u4e14\u9996\u540d\u53c2\u4e0e\u6b64\u7814\u7a76\u7684NSCLC\u60a3\u8005\u5176\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u5df2\u7ecf\u8d85\u8fc7\u4e8610\u4e2a\u6708\uff0c\u663e\u793a\u4e86LOXO-292\u7684\u6301\u4e45\u7597\u6548\u3002\u53e6\u5916\uff0c\u8003\u8651\u5230\u8fd9\u4e9b\u60a3\u8005\u4e4b\u524d\u90fd\u7ecf\u8fc7\u4e86\u5927\u91cf\u6cbb\u7597\uff0c\u6709\u4e9b\u90fd\u53d1\u751f\u4e86\u8111\u8f6c\u79fb\uff0c\u8fd9\u4e9b\u6570\u636e\u663e\u5f97\u66f4\u52a0\u96be\u80fd\u53ef\u8d35\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">2017\u5e745\u6708\uff0cFDA\u6279\u51c6\u4e86\u9ed8\u6c99\u4e1c\u7684PD-1\u6297\u4f53pembrolizumab\u7528\u4e8e\u6cbb\u7597\u5e26\u6709\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI-H\uff09\u6216\u643a\u5e26\u4fee\u8865\u9519\u914d\u7f3a\u9677\uff08dMMR\uff09\u7684\u65e0\u6cd5\u624b\u672f\/\u8f6c\u79fb\u5b9e\u4f53\u7624\uff0c\u6210\u4e3aFDA\u53f2\u4e0a\u7b2c\u4e00\u6b21\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u800c\u975e\u57fa\u4e8e\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\u6279\u51c6\u836f\u54c1\uff0c\u5f00\u542f\u4e86\u201c\u6cdb\u764c\u75c7\u201d\u6cbb\u7597\u7684\u65b0\u65b9\u5411\u3002\u5728\u8fd9\u4e4b\u540e\uff0cLoxo Oncology\u516c\u53f8\u5e26\u6765\u7684RET\u6291\u5236\u5242LOXO-292\u3001TRK\u6291\u5236\u5242larotrectinib\u6709\u671b\u7ed9\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u9886\u57df\u5e26\u6765\u66f4\u591a\u7684\u7cbe\u51c6\u836f\u7269\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532924032.png\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -28px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: #c5e3d3;padding: 2px 14px;border-style: solid;border-width: 3px;border-radius: 0px;border-color: #ffffff;box-sizing: border-box;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #557d62;padding-right: 5px;padding-left: 5px;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"color: rgb(0, 0, 0);font-family: sans-serif;text-align: justify;text-indent: 28px;white-space: normal;\">RET\u5728\u7814\u836f\u7269<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u636eInforma\u6570\u636e\u5e93\uff0c\u5168\u7403RET\u6291\u5236\u5242\u7814\u53d1\u9886\u57df\u6392\u540d\u9760\u524d\u7684\u516c\u53f8\u4e3b\u8981\u6709Exelixis\u3001\u5b89\u8fdb\u3001\u8d5b\u8bfa\u83f2\u548c\u6b66\u7530\uff0c\u5b83\u4eec\u90fd\u6709\u5404\u81ea\u83b7\u6279\u4e0a\u5e02\u7684RET\u6291\u5236\u5242\uff08\u56fe1\uff09\u3002\u76ee\u524d\u5df2\u4e0a\u5e02\u7684RET\u6291\u5236\u5242\u4e3b\u8981\u662f\u591a\u6fc0\u9176\u6291\u5236\u5242\u7c7b\u836f\u7269\uff0c\u4f8b\u5982\u5361\u535a\u66ff\u5c3c\uff08\u7528\u4e8e\u6cbb\u7597\u7532\u72b6\u817a\u764c\u3001\u80be\u7ec6\u80de\u764c\uff09\u662fVEGFR\u3001c-Met\u3001FLT-3\u3001TIE-1\/2\u3001Kit\u548cRET\u6291\u5236\u5242\u3001\u51e1\u5fb7\u4ed6\u5c3c\uff08\u7528\u4e8e\u6cbb\u7597\u7532\u72b6\u817a\u764c\uff09\u662fEGFR\u3001VEGF\u548cRET\u6291\u5236\u5242\uff0c\u7531\u4e8e\u9776\u5411\u6027\u4e0d\u9ad8\uff0c\u901a\u5e38\u4f1a\u53d1\u751f\u8131\u9776\u5bfc\u81f4\u7684\u76f8\u5173\u6bd2\u6027\u3002\u8fd9\u4e9b\u5df2\u4e0a\u5e02\u7684RET\u6291\u5236\u5242\u76ee\u524d\u90fd\u5728\u79ef\u6781\u5730\u6269\u5c55\u9002\u5e94\u75c7\uff0c\u5b89\u8fdb\u7684\u7d22\u62c9\u83f2\u5c3c\u9488\u5bf9\u4e73\u817a\u764c\u548c\u5b9e\u4f53\u7624\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u2162\u671f\u7814\u7a76\uff08\u88681\uff09\uff0c\u5361\u535a\u66ff\u5c3c\u9488\u5bf9\u5305\u62ecNSCLC\u5728\u5185\u7684\u591a\u4e2a\u9002\u5e94\u75c7\u5df2\u8fdb\u5165\u4e34\u5e8a\u2161\u671f\u7814\u7a76\uff0c\u6b66\u7530\u7684\u666e\u7eb3\u66ff\u5c3c\u9488\u5bf9\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u548c\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u7684\u7814\u53d1\u4e5f\u5904\u4e8e\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u9636\u6bb5\u3002\u5c24\u5176\u503c\u5f97\u4e00\u63d0\u7684\u662f\u5206\u522b\u6765\u81eaLoxo Oncology\u548cBlueprint\u516c\u53f8\u7684LOXO-292\u548cBLU-667\uff0c\u8fd9\u4e24\u4e2a\u5728\u7814\u836f\u7269\u90fd\u662f\u65b0\u4e00\u4ee3\u9009\u62e9\u6027RET\u6291\u5236\u5242\uff0c\u51ed\u501f\u7740\u4f18\u5f02\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u4e24\u5bb6\u516c\u53f8\u90fd\u5728\u8fd1\u671f\u540d\u58f0\u5927\u566a\u3002Blueprint\u516c\u53f8\u66fe\u57282018\u5e74AACR\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86BLU-667\u7684\u2160\u671f\u6570\u636e\uff0c\u9488\u5bf9RET\u7a81\u53d8\u6216\u8005\u878d\u5408\u7684\u80bf\u7624\u60a3\u8005\uff0cBLU-667\u7684\u6709\u6548\u7387\u9ad8\u8fbe46%\uff0c\u63a7\u5236\u7387\u8d85\u8fc790%\uff0c\u4e14\u526f\u4f5c\u7528\u6bd4\u8f83\u5c0f\uff0c\u5927\u90e8\u5206\u526f\u4f5c\u7528\u90fd\u5f88\u8f7b\u5fae\u3002\u8fd9\u4e9b\u836f\u7269\u7684\u60ca\u4eba\u8868\u73b0\u9884\u793a\u7740\u7cbe\u51c6\u836f\u7269\u7814\u53d1\u7684\u5de8\u5927\u8fdb\u6b65\uff0c\u4e5f\u7ed9RET\u7a81\u53d8\u6216\u878d\u5408\u7684\u80bf\u7624\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u671f\u5f85\u5b83\u4eec\u5728\u63a5\u4e0b\u6765\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f9d\u7136\u4f1a\u6709\u4e0d\u4fd7\u7684\u8868\u73b0\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: justify;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);margin-top: 15px;line-height: 2em;text-indent: 0em;\"><img loading=\"lazy\" class=\"\"        height=\"308\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" width=\"579\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532924032.jpeg\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 14px;\">\u6ce8\uff1a\u56fe\u4e2d\u6570\u91cf\u6307\u5728\u7814\u9002\u5e94\u75c7<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);margin-top: 15px;line-height: 2em;text-indent: 0em;\"><span style=\"font-size: 14px;\">\u56fe1\uff1a\u5168\u7403RET\u6291\u5236\u5242\u7814\u53d1\u9886\u57df\u6392\u540d\u524d\u5341\u7684\u516c\u53f8<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);margin-top: 15px;line-height: 2em;text-indent: 0em;\"><span style=\"font-size: 14px;\">\u88681\uff1a\u5168\u7403\u5904\u4e8e\u4e0a\u5e02\u53ca\u4e34\u5e8a\u9636\u6bb5\u7684\u5728\u7814RET\u6291\u5236\u5242<\/span><\/p>\n<p style=\"text-align: center;margin-top: 15px;line-height: 2em;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"535\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" width=\"560\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532924033.jpg\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532924033.png\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -28px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: #c5e3d3;padding: 2px 14px;border-style: solid;border-width: 3px;border-radius: 0px;border-color: #ffffff;box-sizing: border-box;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;padding-right: 5px;padding-left: 5px;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: justify;text-indent: 28px;box-sizing: border-box;\"><span style=\"font-family:sans-serif;\"><strong>\u514d\u75ab\u7597\u6cd5&nbsp; &nbsp;<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u81ea\u4e0a\u5e02\u4ee5\u6765\uff0c\u9010\u6e10\u6210\u4e3a\u6297\u80bf\u7624\u836f\u7269\u6cbb\u7597\u9886\u57df\u7684\u91cd\u5934\u620f\u3002\u76ee\u524d\u4e0a\u5e02\u7684PD-(L)1\u6291\u5236\u5242\u5df2\u7ecf\u5728\u8d85\u8fc720\u79cd\u764c\u75c7\u9002\u5e94\u75c7\u4e2d\u5f97\u5230\u5e94\u7528\uff0c\u80ba\u764c\u9886\u57df\u7684\u8868\u73b0\u5c24\u4e3a\u7a81\u51fa\uff0c\u9ed8\u6c99\u4e1c\u7684\u738b\u724c\u836f\u7269Pembrolizumab\u5df2\u7ecf\u4e24\u6b21\u83b7\u6279\u7528\u4e8e\u67d0\u4e9bNSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u30022018\u5e74ASCO\u4f1a\u8bae\u4e0a\uff0c\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5\uff0c\u5c24\u5176\u662fPD-(L)1\u6291\u5236\u5242\u8054\u5408\u7597\u6cd5\u7ee7\u7eed\u7ed9\u6211\u4eec\u5448\u73b0\u4e86\u4e00\u7cfb\u5217\u53ef\u559c\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">PD-(L)1\u6291\u5236\u5242\u7684\u5728\u7814\u9002\u5e94\u75c7\u901a\u5e38\u4e0e\u60a3\u8005\u4f53\u5185PD-(L)1\u7684\u8868\u8fbe\u6709\u5173\uff0c\u662f\u5178\u578b\u7684\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u3002\u76ee\u524d\u4e0a\u5e02\u7684PD-1\u5355\u6297\u836f\u6709\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo\uff08nivolumab\uff09\u548c\u9ed8\u6c99\u4e1c\u7684Keytruda\uff08pembrolizumab\uff09\uff0cPD-L1\u5355\u6297\u836f\u6709\u7f57\u6c0f\u7684Tecentrip\uff08atezolizumab\uff09\uff0c\u9ed8\u514b\/\u8f89\u745e\u8054\u5408\u5f00\u53d1\u7684Bavencio\uff08avelumab\uff09\uff0c\u963f\u65af\u5229\u5eb7\u7684Imfinzi\uff08durvalumab\uff09\u3002\u53e6\u5916\uff0c\u518d\u751f\u5143\/\u8d5b\u8bfa\u83f2\u8054\u5408\u5f00\u53d1\u7684cemiplimab\u6709\u671b\u6210\u4e3a\u7b2c\u4e09\u4e2a\u4e0a\u5e02\u7684PD-1\u5355\u6297\u836f\uff0c\u7528\u4e8e\u6cbb\u7597\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\u3002\u8fd9\u4e9bPD-(L)1\u514d\u75ab\u7597\u6cd5\u9886\u57df\u7684\u7814\u53d1\u5de8\u5934\u90fd\u5728ASCO\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86\u81ea\u5bb6\u4ea7\u54c1\u7684\u7814\u53d1\u8fdb\u5c55\u3002\u4ece\u4f1a\u8bae\u4e0a\u62ab\u9732\u7684\u6570\u636e\u6765\u770b\uff0c\u9ed8\u6c99\u4e1c\u65e0\u7591\u6210\u4e3a\u6700\u5927\u8d62\u5bb6\u3002\u4e24\u4e2a\u2162\u671f\u7814\u7a76\u7ed3\u679c\u7684\u62ab\u9732\u5c06\u4f7fpembrolizumab\u5728NSCLC\u4e00\u7ebf\u6cbb\u7597\u9886\u57df\u7684\u4f18\u52bf\u5730\u4f4d\u66f4\u52a0\u7a33\u56fa\u3002<\/span><\/p>\n<p style=\"text-align: justify;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-top: 15px;line-height: 2em;\"><img loading=\"lazy\" class=\"\"        height=\"318\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" width=\"629\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532924033.jpeg\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: left;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 14px;\">\u6ce8\uff1aAgilent\u83b7\u6279\u4ea7\u54c1\u4e3a\u5176\u65d7\u4e0bDako\u516c\u53f8\u7814\u53d1\u7684PD-L1 IHC 22C3 pharmDx\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\uff1b\u56fe\u4e2d\u6570\u91cf\u6307\u5728\u7814\u9002\u5e94\u75c7<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u56fe2\uff1a\u5168\u7403PD-(L)1\u5355\u6297\u7814\u53d1\u9886\u57df\u6392\u540d\u524d\u5341\u7684\u516c\u53f8<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\"><strong>Pembrolizumab<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u5728\u4e00\u9879\u540d\u4e3aKeynote-407\u7684\u9488\u5bf9\u9cde\u72b6\u7ec6\u80deNSCLC\u7684\u8bd5\u9a8c\u4e2d\uff0cpembrolizumab\u8054\u5408\u5316\u7597\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8636%\u3002\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u60a3\u8005\u5e94\u6709\u4e0d\u540c\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5bf9\u4e8ePD-L1\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\uff0c\u63a5\u53d7pembrolizumab\u5355\u836f\u6cbb\u7597\u5373\u53ef\u4ee5\u53d6\u5f97\u975e\u5e38\u597d\u7684\u7597\u6548\uff0c\u518d\u8054\u5408\u5316\u7597\uff0c\u60a3\u8005\u7684\u989d\u5916\u83b7\u76ca\u4e0d\u90a3\u4e48\u660e\u663e\u3002\u4f46\u5bf9\u4e8ePD-L1\u4f4e\u8868\u8fbe\u7684\u60a3\u8005\uff0c\u5373PD-L1\u8868\u8fbe1~49%\u7684\u60a3\u8005\uff0c\u57fa\u4e8eKeynote-407\u548cKeynote-189\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u5e94\u8be5\u8003\u8651pembrolizumab\u8054\u5408\u5316\u7597\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">Pembrolizumab\u4e8e2016\u5e74\u83b7\u6279\u7528\u4e8ePD-L1\u9ad8\u8868\u8fbe\uff08\u226550%\uff09\u7684\u665a\u671fNSCLC\u521d\u59cb\u6cbb\u7597\uff0c\u8fd9\u7c7b\u60a3\u8005\u5360\u6240\u6709\u80ba\u764c\u60a3\u8005\u76841\/3\u3002PD-L1\u9ad8\u8868\u8fbe\u80bf\u7624\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u53cd\u5e94\u66f4\u597d\uff0c\u4f46\u6709\u4e00\u4e9b\u7814\u7a76\u4e5f\u663e\u793a\uff0c\u5728PD-L1\u4f4e\u8868\u8fbe\u6216\u4e0d\u8868\u8fbe\u7684\u80bf\u7624\u4e2d\uff0c\u8fd9\u4e9b\u514d\u75ab\u7597\u6cd5\u4f9d\u7136\u6709\u6548\u3002\u4e00\u9879\u540d\u4e3aKEYNOTE-042\u7684\u2162\u671f\u968f\u673a\u4e34\u5e8a\u7814\u7a76\u65e8\u5728\u63a2\u8ba8\u5728TPS\uff08tumor proportion scores\uff0c\u7528\u4e8e\u8868\u793aPD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u9ad8\u4f4e\uff09\u22651%\u7684NSCLC\u4e00\u7ebf\u6cbb\u7597\u4e2d\uff0cpembrolizumab\u662f\u5426\u4f18\u4e8e\u5316\u7597\u3002\u7814\u7a76\u7eb3\u51651274\u4f8b\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u4e00\u7ebf\u7ed9\u4e88\u5316\u7597\uff08\u7d2b\u6749\u9187+\u5361\u94c2\u6216\u57f9\u7f8e\u66f2\u585e+\u5361\u94c2\uff09\u6216pembrolizumab\uff0c\u80bf\u7624\u7c7b\u578b\u5305\u62ec\u9cde\u764c\u548c\u975e\u9cde\u764c\uff0c\u4f46\u6392\u9664\u4e86\u53ef\u7528\u9776\u5411\u836f\u7269\uff08EGFR\u548cALK\u6291\u5236\u5242\uff09\u6cbb\u7597\u7684\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u3002\u6839\u636ePD-L1\u8868\u8fbe\u6c34\u5e73\u5206\u4e3a3\u7ec4\uff1a\u226550%\u7ec4\u3001\u226520%\u7ec4\u4ee5\u53ca\u22651%\u7ec4\uff0c\u6bcf\u7ec4\u63a5\u53d7pembrolizumab\u548c\u5316\u7597\u7684\u60a3\u8005\u6570\u91cf\u76f8\u540c\u3002\u7814\u7a76\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a12.8\u4e2a\u6708\u3002pembrolizumab\u663e\u8457\u6539\u5584TPS\u226550%\u3001\u226520%\u548c\u22651%\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u4e09\u7ec4\u60a3\u8005\u4e2d\u4f4dOS\u5747\u957f\u4e8e\u63a5\u53d7\u6807\u51c6\u5316\u7597\u65b9\u6848\u8005\uff0c\u98ce\u9669\u6bd4\uff08HR\uff09\u5206\u522b\u4e3a0.69\u30010.77\u548c0.81\u3002\u6b64\u5916\uff0cPD-L1\u8868\u8fbe\u6c34\u5e73\u8d8a\u9ad8\uff0cPembrolizumab\u6cbb\u7597\u6548\u679c\u8d8a\u597d\uff1a\u226550%\u7ec4\uff0820\u4e2a\u6708 vs. 12.2\u4e2a\u6708\uff09\uff0c\u226520%\u7ec4\uff0817.7\u4e2a\u6708 vs. 13\u4e2a\u6708)\uff0c\u22651%\u7ec4\uff0816.7\u4e2a\u6708 vs. 12.1\u4e2a\u6708)\u3002\u8be5\u7814\u7a76\u662fpembrolizumab\u5355\u836f\u6cbb\u7597\u6700\u5927\u6837\u672c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc1\u5b9e\u4e86pembrolizumab\u5355\u836f\u4f5c\u4e3aPD-L1\u9633\u6027\u665a\u671f\/\u8f6c\u79fb\u6027NSCLC\u6807\u51c6\u4e00\u7ebf\u6cbb\u7597\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\"><strong>\u5176\u5b83PD-(L)1\u5355\u6297<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5728ASCO\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86\u2162\u671f\u7814\u7a76CheckMate-227\u7684\u90e8\u5206\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u4e0e\u5316\u7597\u76f8\u6bd4\uff0cnivolumab\u8054\u5408\u4f4e\u5242\u91cfipilimumab\u3001\u4ee5\u53canivolumab\u8054\u5408\u5316\u7597\u5728\u665a\u671fNSCLC\uff08PD-L1 &lt;1%\uff0c\u5305\u62ec\u9cde\u764c\u53ca\u975e\u9cde\u764c\uff09\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u3002\u6570\u636e\u663e\u793a\uff0c\u5728PD-L1 &lt;1%\u60a3\u8005\u4e2d\uff0c\u4e0e\u5316\u7597\uff08n=186\uff09\u76f8\u6bd4\uff0cnivolumab\u8054\u5408\u5316\u7597\uff08n=177\uff09\u80fd\u591f\u5ef6\u957f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u5728\u5bf9\u9ad8\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\u226510\u4e2a\u7a81\u53d8\/Mb\uff09\u4e14PD-L1 &lt;1%\u7684\u60a3\u8005\u8fdb\u884c\u63a2\u7d22\u6027\u5206\u6790\u65f6\uff0cnivolumab\u8054\u5408\u4f4e\u5242\u91cfipilimumab\u7ec4\uff08n=38\uff09\u7684\u4e00\u5e74PFS\u7387\u4e3a45%\uff0cnivolumab\u8054\u5408\u5316\u7597\u7ec4\uff08n=43\uff09\u4e3a27%\uff0c\u5316\u7597\u7ec4\uff08n=48\uff09\u4e3a8%\u3002\u5728\u4f4e\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB&lt;10\u4e2a\u7a81\u53d8\/Mb\uff09\u4e14PD-L1&lt;1%\u7684\u60a3\u8005\u4e2d\uff0cnivolumab\u8054\u5408\u4f4e\u5242\u91cfipilimumab\u7ec4\uff08n=52\uff09\u548cnivolumab\u8054\u5408\u5316\u7597\u7ec4\uff08n=54\uff09\u7684\u4e00\u5e74PFS\u7387\u5747\u4e3a18%\uff0c\u5316\u7597\u7ec4\uff08n=59\uff09\u4e3a16%\u3002\u8fd9\u4e9b\u7ed3\u679c\u5c06\u6709\u52a9\u4e8e\u533a\u5206\u54ea\u4e9b\u4eba\u80fd\u4ece\u514d\u75ab\u8054\u5408\u7597\u6cd5\u4e2d\u53d7\u76ca\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u9664\u4e86\u4e0a\u8ff0\u4e24\u4e2a\u4e0a\u5e02\u7684PD-1\u5355\u6297\uff0c\u8d5b\u8bfa\u83f2\u548c\u518d\u751f\u5143\u4e5f\u5728ASCO\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86\u5176\u5171\u540c\u5f00\u53d1\u7684PD-1\u5355\u6297cemiplimab\u5728\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\uff08CSCC\uff09\u4e2d\u7684\u7597\u6548\u3002\u8be5\u9879\u2161\u671f\u4e34\u5e8a\u7814\u7a76EMPOWER-CSCC-1\uff0c\u6570\u636e\u6765\u81ea59\u4f8b\u8f6c\u79fb\u6027CSCC\u60a3\u8005\u3002cemiplimab\u6cbb\u7597\u7684\u603b\u7f13\u89e3\u7387\u4e3a47.5%\uff08n=28\/59\uff0c4\u4f8b\u5b8c\u5168\u7f13\u89e3\uff0c24\u4f8b\u90e8\u5206\u7f13\u89e3\uff09\uff0c\u8fbe\u5230\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a2\u4e2a\u6708\uff0c\u9884\u8ba1\u7684\u4e00\u5e74\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u4e3a52.5%\uff0c\u9884\u8ba1\u7684\u4e00\u5e74\u751f\u5b58\u7387\u4e3a81%\u3002\u53e6\u5916\uff0c\u7531\u8bfa\u534e\u5e26\u6765\u7684spartalizumab\u5219\u5728\u665a\u671f\u7532\u72b6\u817a\u672a\u5206\u5316\u764c\u4e2d\u53d6\u5f97\u4e8616.7%\u7684\u603b\u4f53\u7f13\u89e3\u7387\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u5728PD-L1\u6291\u5236\u5242\u65b9\u9762\uff0c\u7f57\u6c0f\u7684\u514d\u75ab\u7597\u6cd5atezolizumab\u5728\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8cIMpower131\u4e2d\u4e5f\u53d6\u5f97\u4e86\u51fa\u8272\u7684\u6210\u679c\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u4e861021\u4f8b\u2163\u671f\u9cde\u72b6NSCLC\u60a3\u8005\uff0c\u68c0\u6d4b\u5176\u80bf\u7624PD-L1\u8868\u8fbe\u60c5\u51b5\uff0c\u4f46\u65e0\u8bba\u80bf\u7624PD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u60a3\u8005\u5747\u88ab\u7eb3\u5165\u8bd5\u9a8c,\u6709EGFR\u7a81\u53d8\u6216ALK\u57fa\u56e0\u91cd\u6392\u8005\u5728\u5165\u7ec4\u524d\u63a5\u53d7\u4e86\u9776\u5411\u6cbb\u7597\u3002\u7ed3\u679c\u663e\u793a\uff0c\u76f8\u6bd4\u53ea\u63a5\u53d7\u5361\u94c2\u548c\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u7684\u5bf9\u7167\u7ec4\uff0c\u989d\u5916\u63a5\u53d7Atezolizumab\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u5c06\u4e00\u5e74\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u4ece12.0%\u63d0\u9ad8\u523024.7%\uff0c\u75be\u75c5\u8fdb\u5c55\u4e0e\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e29%\u3002\u76ee\u524d\u7684\u7814\u7a76\u91cd\u70b9\u5728\u4e8e\u63a2\u7d22\u54ea\u4e9b\u60a3\u8005\u53ef\u4ee5\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca\u6700\u591a\uff0c\u6839\u636ePD-L1\u7684\u8868\u8fbe\u6c34\u5e73\u6216\u5176\u4ed6\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u60a3\u8005\u8fdb\u884c\u5206\u5b50\u5206\u5c42\uff0c\u4ece\u800c\u9884\u6d4b\u60a3\u8005\u80fd\u5426\u4f1a\u4ece\u67d0\u79cd\u6cbb\u7597\u65b9\u6848\u4e2d\u53d7\u76ca\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532924034.png\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -28px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: #c5e3d3;padding: 2px 14px;border-style: solid;border-width: 3px;border-radius: 0px;border-color: #ffffff;box-sizing: border-box;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #557d62;padding-right: 5px;padding-left: 5px;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"color: rgb(0, 0, 0);font-family: sans-serif;text-align: justify;text-indent: 28px;white-space: normal;\">\u7ec6\u80de\u7597\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\"><strong>CAR-T\u7597\u6cd5<\/strong><\/span><br  \/><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u636eInforma\u6570\u636e\uff0c\u5168\u7403CAR-T\u7814\u53d1\u836f\u7269\u7814\u53d1\u6570\u91cf\u81ea2014\u5e74\u4ee5\u6765\u4e00\u76f4\u589e\u957f\u8fc5\u901f\uff0c\u76ee\u524d\u8d70\u5728\u7814\u53d1\u524d\u5217\u7684\u516c\u53f8\u4e3b\u8981\u6709\u8bfa\u534e\u3001\u5409\u5229\u5fb7\u548c\u65b0\u57fa\uff08\u56fe3\uff09\u3002\u7b2c\u4e00\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684CAR-T\u4ea7\u54c1\u662f\u8bfa\u534e\u5236\u836f\u7684Kymriah\uff08tisagenlecleucel\uff09\uff0c\u7b2c\u4e8c\u4e2a\u662f\u5409\u5229\u5fb7\u7684Yescarta\uff08axicabagene ciloleucel\uff09\uff0c\u8fd9\u4e24\u4e2a\u4ea7\u54c1\u5747\u662f\u81ea\u4f53\u7ec6\u80de\u7597\u6cd5\u7684CAR-T\u836f\u7269\u3002\u8bfa\u534e\u7684Kymriah\u5728\u8840\u764c\u7684\u6cbb\u7597\u4e0a\u5df2\u7ecf\u5d2d\u9732\u5934\u89d2\uff0c\u83b7\u6279\u9002\u5e94\u75c7\u5305\u62ec\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002\u8bfa\u534e\u4e0e\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u5408\u4f5c\u7814\u7a76\u5176\u4ed6CAR-T\u7597\u6cd5\u4e8e\u5b9e\u4f53\u7624\u4e0a\u7684\u529f\u6548\uff1aCARTmeso\u9488\u5bf9\u95f4\u76ae\u7624\u548c\u5375\u5de2\u764c\u3001LXF-821\u9488\u5bf9\u8111\u764c\u7b2c\u4e00\u9636\u6bb5\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u5c55\u5f00\u3002\u53e6\u5916\uff0c\u6bd4\u5229\u65f6Celyad\u516c\u53f8\u5df2\u5f00\u5c55\u7b2c\u4e8c\u9636\u6bb5\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc4\u4f30\u5176CAR-T\u7597\u6cd5\uff08NKR-2\uff09\u5bf9\u591a\u79cd\u5b9e\u8d28\u56fa\u6001\u7624\uff08\u8180\u80f1\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\uff09\u7684\u529f\u6548\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);margin-top: 15px;line-height: 2em;text-indent: 0em;\"><img loading=\"lazy\" class=\"\"     height=\"318\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" width=\"601\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532924034.jpeg\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: left;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 14px;\">\u6ce8\uff1a\u56fe\u4e2d\u6570\u91cf\u6307\u5728\u7814\u9002\u5e94\u75c7<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u56fe3\uff1a\u5168\u7403CAR-T\u7814\u53d1\u9886\u57df\u6392\u540d\u524d\u5341\u7684\u516c\u53f8<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u9488\u5bf9BCMA\u9776\u6297\u539f\u7684CAR-T\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u6548\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u7279\u522b\u662f\u9488\u5bf9\u591a\u836f\u8010\u836f\u7684\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7597\u6548\u786e\u5207\u3002\u6211\u56fd\u751f\u7269\u79d1\u6280\u516c\u53f8\u5357\u4eac\u4f20\u5947\u5728\u53bb\u5e74\u7684ASCO\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86\u4e00\u987935\u4f8b\u590d\u53d1\u6027\u6216\u8010\u836f\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u53c2\u4e0e\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176CAR-T\u7597\u6cd5\uff08LCAR-B38M\uff09\u5e26\u6765\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe\u5230100%\u30022017\u5e74\u5e95\uff0cLCAR-B38M\u7684\u4e2d\u56fd\u4e34\u5e8a\u7533\u8bf7\uff08CXSL1700201\uff09\u83b7\u5f97CDE\u6b63\u5f0f\u627f\u529e\u53d7\u7406\u3002\u968f\u540e\uff0c\u5f3a\u751f\u516c\u53f8\u4e0e\u5357\u4eac\u4f20\u5947\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u5171\u540c\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u8be5\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u7531\u65b0\u57fa\/Bluebird Bio\u5171\u540c\u7814\u53d1\u7684BB2121\u4e5f\u662f\u4e00\u9879\u6297BCMA\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u30022018\u5e74ASCO\u4f1a\u8bae\u4e0a\u66f4\u65b0\u4e86\u5176\u6cbb\u7597\u590d\u53d1\u3001\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u2160\u671f\u591a\u4e2d\u5fc3\u7814\u7a76\u7ed3\u679c\u300222\u540d\u63a5\u53d7\u6700\u9ad8\u5242\u91cfBB2121\u6cbb\u7597\u7684\u75c5\u4eba\u4e2d21\u4eba\u4ea7\u751f\u4e86\u5e94\u7b54\uff0c11\u4eba\u5b8c\u5168\u5e94\u7b54\u3002\u6700\u9ad8\u5242\u91cf\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a11.8\u4e2a\u6708\uff0c\u800c\u4f4e\u5242\u91cf\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u53ea\u67091.9\u4e2a\u6708\u3002Bluebird\u7684CEO Nick Leschly\u8ba4\u4e3a\uff0c\u5165\u7ec4\u63a5\u53d7\u6cbb\u7597\u7684\u75c5\u4eba\u75c5\u60c5\u90fd\u5df2\u7ecf\u975e\u5e38\u4e25\u91cd\uff0c\u8fd9\u4e9b\u75c5\u4eba\u6b64\u524d\u5e73\u5747\u63a5\u53d7\u8fc77\u79cd\u7597\u6cd5\uff0c\u6bcf\u4f4d\u75c5\u4eba\u90fd\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u5bf9\u4e8e\u8fd9\u4e9b\u60a3\u8005\u6765\u8bf4\u8fd9\u6837\u7684\u6570\u636e\u5df2\u7ecf\u8db3\u591f\u4f18\u79c0\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u9664\u6b64\u4e4b\u5916\uff0c\u5728ASCO\u5e74\u4f1a\u4e0a\uff0c\u65b0\u57fa\u8fd8\u516c\u5e03\u4e86JCAR017\uff08\u65b0\u57fa\u9ad8\u4ef7\u6536\u8d2dJuno 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style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\"><strong>T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7597\u6cd5<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">TCR\u7597\u6cd5\u662f\u4e00\u79cd\u6fc0\u6d3b\u4eba\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u548c\u6740\u4f24\u7279\u5b9a\u80bf\u7624\u7684\u4e2a\u4f53\u5316\u514d\u75ab\u7597\u6cd5\uff08\u56fe4\uff09\u3002\u5b83\u6536\u96c6\u60a3\u8005\u7684T\u6dcb\u5df4\u7ec6\u80de\uff0c\u7136\u540e\u5728\u8fd9\u4e9b\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u9776\u5411\u7279\u5b9a\u80bf\u7624\u6297\u539f\u7684\u5929\u7136\u6dcb\u5df4\u7ec6\u80de\u53d7\u4f53\u3002Kite\u516c\u53f8\u53ef\u4ee5\u8bf4\u662fTCR\u7597\u6cd5\u7684\u5148\u9a71\uff0c\u5176\u7814\u53d1\u4eba\u5458\u5206\u79bb\u51fa\u5185\u6e90\u7684TCR\uff0c\u5e76\u52a0\u4ee5\u5de5\u7a0b\u5316\u6539\u9020\uff0c\u5c06\u5176\u5f15\u5165\u5168\u65b0\u7684T\u7ec6\u80de\uff0c\u5e76\u8f93\u6ce8\u56de\u4eba\u4f53\u3002\u8fd9\u6837\u4e00\u6765\uff0c\u5e26\u6709\u9776\u5411\u764c\u7ec6\u80de\u80fd\u529b\u7684T\u7ec6\u80de\u6570\u91cf\u5c06\u5927\u589e\uff0c\u6709\u671b\u5bf9\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u4e0e\u8840\u6db2\u80bf\u7624\u8fdb\u884c\u8bc6\u522b\u4e0e\u653b\u51fb\u3002Kite\u516c\u53f8\u5728\u7814\u7684TCR\u7597\u6cd5\u4e3b\u8981\u6709KITE-439\u548cKITE-718\u3002KITE-718\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u9488\u5bf9\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u2160\u671f\u7814\u7a76\uff0c\u9776\u5411\u7684\u662fMAGE A3\/A6\u6297\u539f\u3002\u8fd9\u79cd\u764c\u75c7\u6297\u539f\u5728\u8180\u80f1\u764c\u3001\u98df\u7ba1\u764c\u3001\u5bab\u9888\u764c\u3001\u5934\u9888\u764c\u3001\u80ba\u764c\u3001\u5375\u5de2\u764c\u3001\u4ee5\u53ca\u5176\u4ed6\u764c\u75c7\u4e2d\u666e\u904d\u5b58\u5728\u3002KITE-439\u5219\u662f\u4e00\u79cd\u9776\u5411E7\u86cb\u767d\u7684TCR\u7597\u6cd5\u3002\u7531HPV\u5bfc\u81f4\u7684\u4e0a\u76ae\u764c\u7684\u80bf\u7624\u7ec6\u80de\u4e2d\u4f1a\u8868\u8fbeE7\u86cb\u767d\u3002<\/span><\/p>\n<p style=\"text-align: justify;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);margin-top: 15px;line-height: 2em;text-indent: 0em;\"><img loading=\"lazy\" class=\"\"         height=\"448\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" width=\"308\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532924034.jpeg\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u56fe4\uff1aTCR\u7597\u6cd5\u539f\u7406\uff08\u56fe\u7247\u4fee\u6539\u81eaKite\u5b98\u7f51\uff09<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">Kite\u516c\u53f8\u57282018 ASCO\u5e74\u4f1a\u4e0a\u53d1\u5e03\u4e86\u5176\u5728\u7814TCR\u7597\u6cd5\u6cbb\u7597HPV\u9633\u6027\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u2160\u671f\u8bd5\u9a8c\u7684\u65e9\u671f\u6570\u636e\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u9776\u541116\u578bHPV\uff08HPV-16\uff09\u7684E7\u86cb\u767d\u7684TCR\u7597\u6cd5\u80fd\u591f\u5728\u90e8\u5206HPV-16\u9633\u6027\u764c\u75c7\u60a3\u8005\u8eab\u4e0a\u5b9e\u73b0\u80bf\u7624\u90e8\u5206\u7f13\u89e3\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u5728\u8fd9\u9879\u4ecd\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u2160\u671f\u8bd5\u9a8c\u4e2d\uff0c8\u4f4d\u60a3\u6709\u8f6c\u79fb\u6027HPV-16\u9633\u6027\u80bf\u7624\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u8868\u8fbeE7 TCR\u7684T\u7ec6\u80de\u7597\u6cd5\u3002\u8fd9\u4e9b\u60a3\u8005\u5728\u63a5\u53d7TCR\u7597\u6cd5\u4e4b\u524d\u5df2\u7ecf\u63a5\u53d7\u8fc73\u52307\u79cd\u7cfb\u7edf\u6027\u764c\u75c7\u7597\u6cd5\u3002\u5728\u6700\u521d\u63a5\u53d7TCR\u7597\u6cd5\u76846\u4f4d\u60a3\u8005\u4e2d\uff0c\u6ce8\u5165\u7684T\u7ec6\u80de\u4e2d90~99%\u7684\u7ec6\u80de\u8868\u9762\u8868\u8fbeE7 TCR\uff0c\u800c\u4e14\u8868\u8fbeE7 TCR\u7684T\u7ec6\u80de\u5728\u63a5\u53d7\u6cbb\u7597\u540e6\u5468\u4ecd\u7136\u53ef\u4ee5\u5728\u5916\u5468\u8840\u6db2\u4e2d\u88ab\u68c0\u6d4b\u5230\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u7ed3\u679c\u663e\u793a\uff0c\u57287\u540d\u53ef\u4ee5\u63a5\u53d7\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u67093\u540d\u60a3\u8005\u7684\u80bf\u7624\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\uff0c2\u540d\u60a3\u8005\u7684\u80bf\u7624\u72b6\u6001\u7a33\u5b9a\u3002\u622a\u6b62\u5230\u6570\u636e\u53d1\u5e03\u65f6\uff0c\u5916\u9634\u764c\u3001\u53e3\u54bd\u764c\u548c\u809b\u95e8\u764c\u60a3\u8005\u75c5\u60c5\u90fd\u83b7\u5f97\u4e86\u7f13\u89e3\uff0c\u7f13\u89e3\u671f\u6700\u957f\u53ef\u4ee5\u8fbe\u52309\u4e2a\u6708\uff0c\u5176\u4e2d2\u540d\u60a3\u8005\u66fe\u63a5\u53d7\u8fc7\u6297PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u6ca1\u6709\u51fa\u73b0\u9650\u5236\u7597\u6cd5\u5242\u91cf\u7684\u6bd2\u526f\u4f5c\u7528\u3002Kite\u516c\u53f8\u8ba1\u5212\u5728\u4eca\u5e74\u5e74\u5e95\u4e4b\u524d\u9012\u4ea4\u4f7f\u7528KITE-439\u6cbb\u7597HPV-16 E7\u5b9e\u4f53\u7624\u7684\u7814\u7a76\u6027\u65b0\u836f\u7533\u8bf7\uff08IND\uff09\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532924034.png\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -28px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: #c5e3d3;padding: 2px 14px;border-style: solid;border-width: 3px;border-radius: 0px;border-color: #ffffff;box-sizing: border-box;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #557d62;padding-right: 5px;padding-left: 5px;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"color: rgb(0, 0, 0);font-family: sans-serif;text-align: justify;text-indent: 28px;white-space: normal;\">ALK\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u5728\u80ba\u764c\u4e2d\uff0c\u5927\u7ea6\u670985%\u7684\u75c5\u4f8b\u662f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u5176\u4e2d\uff0c\u6839\u636e\u80bf\u7624\u7ec4\u7ec7\u5b66\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u7684\u7ec4\u6210\u7684\u4e0d\u540c\uff0c\u5927\u7ea63~5%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5448\u73b0ALK\u9633\u6027\u3002\u5728\u8fd9\u4e9b\u80bf\u7624\u4e2d\uff0c\u60a3\u8005\u7684ALK\u57fa\u56e0\u5f80\u5f80\u4f1a\u4e0e\u5176\u4ed6\u57fa\u56e0\u4ea7\u751f\u878d\u5408\uff0c\u751f\u6210ALK\u878d\u5408\u86cb\u767d\uff0c\u4ece\u800c\u5bfc\u81f4\u80bf\u7624\u751f\u957f\u3002ALK\u9633\u6027\u60a3\u8005\u591a\u4e3a\u5e74\u8f7b\u60a3\u8005\uff0c\u5927\u591a\u6570\u5bf9\u5316\u7597\u836f\u7269\u65e0\u54cd\u5e94\uff0c\u6cbb\u7597\u9009\u62e9\u6709\u9650\uff0c\u9884\u540e\u5dee\uff0cALK\u6291\u5236\u5242\u836f\u7269\u7684\u7814\u53d1\u7ed9\u8fd9\u7c7b\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002ALK\u6291\u5236\u5242\u7684\u7814\u53d1\u5df2\u7ecf\u7ecf\u5386\u4e8610\u5e74\u5de6\u53f3\uff0c\u76ee\u524d\uff0c\u5728ALK\u7a81\u53d8\u9633\u6027\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\u5df2\u7ecf\u67094\u4e2a\u540c\u7c7b\u578b\u836f\u7269\u88abFDA\u6279\u51c6\u4e0a\u5e02\uff08\u88682\uff09\u3002\u5305\u62ec\u8f89\u745e\u7684Xalkori\uff08\u4e00\u4ee3\uff09\u3001\u8bfa\u534e\u7684Zykadia\uff08\u4e8c\u4ee3\uff09\u3001\u7f57\u6c0f\u7684Alecensa\uff08\u4e8c\u4ee3\uff09\u548c2017\u5e74\u83b7\u6279\u7684\u6b66\u7530\u7684Alunbrig\uff08\u4e8c\u4ee3\uff09\u30024\u4e2aALK\u6fc0\u9176\u6291\u5236\u5242\u4e0a\u5e02\u836f\u7269\u5747\u83b7\u5f97\u4e86FDA\u7684\u7a81\u7834\u6027\u7597\u6cd5\u548c\u5b64\u513f\u836f\u5730\u4f4d\u8ba4\u5b9a\u3002\u6b64\u5916\uff0c\u8f89\u745e\u7684Lorlatinib\u4e5f\u5df2\u7ecf\u5411FDA\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 15px;\">\u88682\uff1a\u5168\u7403\u4e3b\u8981\u5728\u7814ALK\u6291\u5236\u5242<\/span><\/p>\n<p style=\"text-align: center;margin-top: 15px;line-height: 2em;\"><img loading=\"lazy\" align=\"\" class=\"\"        height=\"497\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" width=\"450\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532924034.jpg\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2018\u5e74ASCO\u4f1a\u8bae\u4e0a\uff0c\u7f57\u6c0f\u516c\u5e03\u4e86alectinib\u7684\u4e00\u9879\u2162\u671fALEX\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u8be5\u7814\u7a76\u662f\u7b2c\u4e00\u9879\u5bf9\u6bd4\u4e8c\u4ee3ALK\u6291\u5236\u5242\u548ccrizotinib\u7684\u7814\u7a76\u3002\u5728\u5ef6\u957f10\u4e2a\u6708\u968f\u8bbf\u540e\uff08crizotinib\u7ec4\u548calectinib\u7ec4\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u5206\u522b\u4e3a22.8\u4e2a\u6708\u548c27.8\u4e2a\u6708\uff09\uff0c\u76f8\u6bd4crizotinib\u7ec4\uff0calectinib\u663e\u8457\u964d\u4f4e57%\u7684\u75be\u75c5\u8fdb\u5c55\/\u6b7b\u4ea1\u98ce\u9669\u3002\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\uff0calectinib\u7ec4\u4e3a34.8\u4e2a\u6708\uff0ccrizotinib\u7ec4\u4ec5\u4e3a10.9\u4e2a\u6708\u3002\u5728\u57fa\u7ebf\u6709\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\uff0calectinib\u7ec4\u548ccrizotinib\u7ec4\u7684mPFS\u5206\u522b\u4e3a27.7\u4e2a\u6708\u548c7.4\u4e2a\u6708\uff1b\u5728\u57fa\u7ebf\u6ca1\u6709\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\uff0cmPFS\u5206\u522b\u4e3a34.8\u4e2a\u6708\u548c14.7\u4e2a\u6708\u3002\u6b64\u5916\uff0cAlectinib\u7ec4\u7528\u836f\u65f6\u95f4\u66f4\u957f\uff0827.0\u4e2a\u6708vs 10.8\u4e2a\u6708\uff09\u7684\u60c5\u51b5\u4e0b\u663e\u793a\u51fa\u66f4\u597d\u7684\u8010\u53d7\u6027\uff0cAlectinib\u7ec4\u76843~5\u7ea7\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u8f83\u4f4e\uff0844.7% vs 51.0%\uff09,\u4e0d\u826f\u53cd\u5e94\u5bfc\u81f4\u5242\u91cf\u51cf\u4f4e\u7684\u60a3\u8005\u6bd4\u4f8b\uff0816.4% vs 20.5%\uff09\u6216\u5242\u91cf\u4e2d\u6b62\u7684\u60a3\u8005\u6bd4\u4f8b\uff0822.4% vs 25.2%\uff09\u8f83\u4f4e\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">Alectinib\u7684\u8d85\u957fPFS\u4e3b\u8981\u5f97\u76ca\u4e8e\u4e24\u4e2a\u539f\u56e0\uff1a\u7b2c\u4e00\uff0c\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u5f3a\uff0c\u51e0\u4e4e\u662f100%\u7684\u900f\u8fc7\u8840\u8111\u5c4f\u969c\u3002\u6b63\u662f\u7531\u4e8e\u8fd9\u4e00\u4fdd\u62a4\u4f5c\u7528\uff0calectinib\u7ec4\u60a3\u8005\u8111\u8f6c\u79fb\u53d1\u751f\u7387\u660e\u663e\u51cf\u5c11\uff0cPFS\u5f97\u4ee5\u5ef6\u957f\u3002\u800c\u5728crizotinib\u65e2\u5f80\u6cbb\u7597\u7814\u7a76\u4e2d\uff0c\u4e09\u5206\u4e4b\u4e00\u7684\u60a3\u8005\u56e0\u4e3a\u8111\u8f6c\u79fb\u8fdb\u5c55\u800c\u6cbb\u7597\u5931\u8d25\u3002\u7b2c\u4e8c\uff0calectinib\u7684\u836f\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u6bd2\u6027\u8f83\u5c0f\uff0c\u4e0d\u826f\u53cd\u5e94\u5bfc\u81f4\u505c\u836f\u6216\u8005\u51cf\u91cf\u7684\u60a3\u8005\u660e\u663e\u51cf\u5c11\u3002<\/span><\/p>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">Alectinib\u76ee\u524d\u5df2\u88ab\u5217\u5165CFDA\u4f18\u5148\u5ba1\u6279\u76ee\u5f55\uff0c\u65e0\u8bba\u5728\u6709\u6548\u6027\u8fd8\u662f\u5b89\u5168\u6027\u65b9\u9762\u90fd\u5b8c\u80dc\u4e00\u4ee3\u836f\u7269crizotinib\u3002ALEX\u7814\u7a76\u4e2d\uff0c\u4e2d\u56fd\u60a3\u8005\u53ea\u670920\u4f59\u4f8b\uff0c\u56e0\u6b64alectinib\u7684\u5ba1\u6279\u4e3b\u8981\u91c7\u7528\u56fd\u9645\u6570\u636e\u3002\u671f\u5f85alectinib\u53ef\u4ee5\u5c3d\u5feb\u83b7\u6279\uff0c\u53ca\u65e9\u60e0\u53ca\u4e2d\u56fdNSCLC\u60a3\u8005\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;\"  class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532924035.png\" alt=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\" title=\"\u4eceASCO\u4f1a\u8bae\u770b\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\"  \/><\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -28px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: #c5e3d3;padding: 2px 14px;border-style: solid;border-width: 3px;border-radius: 0px;border-color: #ffffff;box-sizing: border-box;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #557d62;padding-right: 5px;padding-left: 5px;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"color: rgb(0, 0, 0);font-family: sans-serif;text-align: justify;text-indent: 28px;white-space: normal;\">PARP\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">PARP\u662f\u4e00\u79cd\u5355\u94feDNA\u4fee\u590d\u9176\uff0c\u5176\u901a\u8fc7\u78b1\u57fa\u5207\u9664\u4fee\u590d\uff08Base excision 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style=\"margin-bottom: 20px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u524d\u5217\u817a\u764c\u662f\u7537\u6027\u7b2c\u4e8c\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u662f\u6cbb\u7597\u9009\u62e9\u6709\u9650\u7684\u9ad8\u5371\u4eba\u7fa4\u3002olaparib\u662f\u9996\u4e2a\u5728\u524d\u5217\u817a\u764c\u4e2d\u8bc1\u660e\u4e0e\u6807\u51c6\u6cbb\u7597\u76f8\u7ed3\u5408\u5177\u6709\u6d3b\u6027\u7684PARP\u6291\u5236\u5242\uff0c\u671f\u5f85\u8be5\u7597\u6cd5\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden 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rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 15px;line-height: 2em;\"><span style=\"font-size: 16px;\">\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\uff0c\u5f88\u591a\u5927\u578b\u5236\u836f\u4f01\u4e1a\u90fd\u79ef\u6781\u8f6c\u5411\u4e2a\u6027\u5316\u836f\u7269\u7814\u53d1\u3002\u6b63\u5982\u7f57\u6c0f\u5236\u836fCEO Daniel 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Oncology\uff1ahttps:\/\/www.loxooncology.com\/.<\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">4\u3001\u836f\u660e\u5eb7\u5fb7\u3001\u65b0\u6d6a\u533b\u836f\u7b49\u533b\u836f\u5a92\u4f53\u62a5\u9053.<\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">5\u30012018\u5e74ASCO\u5e74\u4f1a\u8fdb\u5c55\u96c6\u8403\uff1ahttps:\/\/www.bjcancer.org\/Html\/News\/Articles\/8390.html.<\/p>\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u521b\u836f\u7f51                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bfb\uff1a2018\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO\uff09\u4f5c\u4e3a\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u76db\u4f1a\uff0c\u5438\u5f15\u4e86\u5168\u7403\u5404\u5927\u79d1\u7814\u673a\u6784\u3001\u6295\u8d44\u673a\u6784 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