{"id":13005,"date":"2018-07-13T01:00:00","date_gmt":"2018-07-30T04:14:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/30\/%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac25%e6%9c%9f\/"},"modified":"2018-07-30T12:14:06","modified_gmt":"2018-07-30T04:14:06","slug":"%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac25%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/13005\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532924045.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f\"  \/><\/p>\n<section class=\"_editor\">\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 1.2em;overflow: hidden !important;box-sizing: border-box;\">\n<section style=\"width: 18px;height: 10px;border-radius: 50%;background: #42c463;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-top: 1px dashed #42c463;border-bottom: 1px dashed #42c463;border-right-color: #42c463;border-left-color: #42c463;margin: 0.5em 2px 0.5em;padding-top: 2px;padding-bottom: 2px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 1.2em;overflow: hidden !important;box-sizing: border-box;\">\n<section style=\"width: 18px;height: 10px;border-radius: 50%;background: 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SimSun;\">4\u3001\u5728\u4e00\u9879\u6781\u4e3a\u91cd\u8981\u7684\u7b2c\u4e09\u9636\u6bb5\u7814\u7a76\u4e2d\uff0cAcceleron\u53ca\u5176\u5408\u4f5c\u4f19\u4f34Celgene\u518d\u6b21\u53d1\u5e03\u4e86\u6f5c\u5728\u91cd\u78c5\u70b8\u5f39\u836f\u7269luspatercept\u7684\u79ef\u6781\u6570\u636e\uff0c\u6570\u636e\u663e\u793a\u8be5\u836f\u7269\u5728\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u5173\u952e\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u6210\u529f\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">5\u3001\u897f\u96c5\u56fe\u9057\u4f20\u5b66\u516c\u53f8\uff08Seattle Genetics\uff09\u4e0e\u5408\u4f5c\u4f19\u4f34\u5b89\u65af\u6cf0\u6765\uff08Astellas\uff09\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\uff0c\u5df2\u5b8c\u6210\u5b9e\u9a8c\u6027\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09enfortumab vedotin\u5173\u952e\u6027\u2161\u671f\u4e34\u5e8a\u7814\u7a76EV-201\u7684\u60a3\u8005\u5165\u7ec4\u3002\u8be5\u7814\u7a76\u5728\u65e2\u5f80\u5df2\u63a5\u53d7\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08CPI\uff09\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u60a3\u8005\u4e2d\u5f00\u5c55\uff0c\u6765\u81ea\u8be5\u7814\u7a76\u9996\u4e2a\u961f\u5217\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u5c06\u57282019\u5e74\u4e0a\u534a\u5e74\u83b7\u5f97\uff0c\u76f8\u5173\u6570\u636e\u5c06\u7528\u4e8e\u652f\u6301enfortumab vedotin\u901a\u8fc7\u7f8e\u56fdFDA\u52a0\u901f\u5ba1\u8bc4\u7a0b\u5e8f\u7684\u76d1\u7ba1\u7533\u8bf7\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">6\u3001PTC Therapeutics\u516c\u53f8\u8fd1\u65e5\u516c\u5e03\u4e86Translarna\uff08ataluren\uff09\u6cbb\u75972-5\u5c81\u65e0\u4e49\u7a81\u53d8\u578b\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\uff08nmDMD\uff09\u60a3\u8005\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76Study 030\u7684\u7ed3\u679c\u3002\u6570\u636e\u663e\u793a\uff0cTranslarna\u5728\u8fd9\u4e00\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u4e0e\u8be5\u836f\u57285\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4e2d\u7684\u4e00\u81f4\u3002\u91cd\u8981\u7684\u662f\uff0c\u6570\u636e\u8fd8\u663e\u793a\uff0cTranslarna\u6cbb\u7597\u7684\u60a3\u8005\u5728\u7b2c28\u5468\u548c\u7b2c52\u5468\u7684\u5b9a\u65f6\u529f\u80fd\u6d4b\u8bd5\u548c\u5317\u6781\u661f\u79fb\u52a8\u8bc4\u4ef7\u91cf\u8868\u65b9\u9762\u8868\u73b0\u51fa\u6539\u5584\uff0c\u5728\u4e00\u5e74\u540e\u7684\u5e73\u5747\u53d8\u5316\u663e\u793a\u51fa25%\u7684\u6539\u5584\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">7\u3001\u8fd1\u65e5\uff0c\u897f\u96c5\u56fe\u7684\u751f\u7269\u5236\u836f\u516c\u53f8CTI BioPharma\u4e0e\u5408\u4f5c\u4f19\u4f34\u65bd\u7ef4\u96c5\u8054\u5408\u5ba3\u5e03\uff0c\u8bc4\u4f30Pixuvri\uff08pixantrone\uff09\u4e0e\u7f8e\u7f57\u534e\uff08rituximab\uff0c\u5229\u59a5\u6614\u5355\u6297\uff09\u7ec4\u5408\u65b9\u6848\u6cbb\u7597\u4fb5\u88ad\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76PIX306\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">8\u3001\u4eca\u65e5\uff0c\u7f57\u6c0f\uff08Roche\uff09\u65d7\u4e0b\u7684\u57fa\u56e0\u6cf0\u514b\uff08Genentech\uff09\u5ba3\u5e03\u5411FDA\u63d0\u4ea4\u4e86\u5173\u4e8eVenclexta\uff08venetoclax\uff09\u7684\u8865\u5145\u65b0\u836f\u7533\u8bf7\uff08sNDA\uff09\u3002\u5982\u679c\u7533\u8bf7\u83b7\u6279\uff0cVenclexta\u53ef\u4e0e\u53bb\u7532\u57fa\u5316\u836f\u7269\u6216\u4f4e\u5242\u91cf\u963f\u7cd6\u80de\u82f7\uff08LDAC\uff09\u8054\u5408\u6cbb\u7597\u4e0d\u9002\u7528\u9ad8\u5242\u91cf\u5316\u7597\u7684\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u521d\u6cbb\u60a3\u8005\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 1.2em;overflow: hidden !important;box-sizing: border-box;\">\n<section style=\"width: 18px;height: 10px;border-radius: 50%;background: #42c463;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-top: 1px dashed #42c463;border-bottom: 1px dashed #42c463;border-right-color: #42c463;border-left-color: #42c463;margin: 0.5em 2px 0.5em;padding-top: 2px;padding-bottom: 2px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 1.2em;overflow: hidden !important;box-sizing: border-box;\">\n<section style=\"width: 18px;height: 10px;border-radius: 50%;background: #42c463;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, 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class=\"\"     height=\"197\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f\" width=\"400\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532924046.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f\"  \/><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">2\u30017\u67086\u65e5\uff0c\u5929\u58eb\u529b\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u5168\u8d44\u5b50\u516c\u53f8\u6c5f\u82cf\u5929\u58eb\u529b\u5e1d\u76ca\u836f\u4e1a\u6709\u9650\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u5316\u836f1\u7c7bTSL-1502\u80f6\u56ca\u548c\u5316\u836f2.2\u7c7b\u4e73\u5242\u7a00\u91ca\u7528\u7d2b\u6749\u9187\u6ce8\u5c04\u6db2\u4e34\u5e8a\u6279\u4ef6\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">3\u30017\u67085\u65e5\uff0c\u6c5f\u82cf\u8c6a\u68ee\u4f0a\u9a6c\u66ff\u5c3c\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u6210\u4e3a\u56fd\u4ea7\u683c\u5217\u536b\u4eff\u5236\u836f\u9996\u5bb6\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u4f01\u4e1a\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">4\u3001\u8fd1\u65e5\uff0c\u6842\u6797\u4e09\u91d1\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u53d1\u5e03\u516c\u544a\uff0c\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u91cd\u7ec4\u6297VEGF\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">5\u3001\u8fd1\u65e5\uff0c\u6df1\u5733\u4fe1\u7acb\u6cf0\u66ff\u683c\u745e\u6d1b\u7247\u4eff\u5236\u836f\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u5b8c\u6210\u4e86\u6280\u672f\u5ba1\u8bc4\u5de5\u4f5c\uff0cCFDA\u4fe1\u606f\u516c\u793a\u5e73\u53f0\u663e\u793a\u7684\u529e\u7406\u72b6\u6001\u53d8\u66f4\u4e3a&#8221;\u5728\u5ba1\u6279&#8221;\u3002\u6309\u7167\u901a\u5e38\u5ba1\u6279\u7684\u65f6\u9650\u6765\u4f30\u7b97\uff0cCFDA\u5c06\u4e8e\u672c\u6708\u5e95\u6216\u4e0b\u6708\u521d\u5b8c\u6210\u6700\u540e\u7684\u5ba1\u6279\u5de5\u4f5c\uff0c\u8fd9\u9884\u793a\u7740\u56fd\u4ea7\u66ff\u683c\u745e\u6d1b\u7247\u4eff\u5236\u836f\u5373\u5c06\u4e0a\u5e02\uff0c\u4fe1\u7acb\u6cf0\u8fd1\u671f\u6709\u671b\u62ff\u4e0b\u8fd9\u6b3e\u91cd\u78c5\u836f\u7269\u7684\u56fd\u5185\u9996\u4eff\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">6\u3001\u4e2d\u56fd\u53f0\u6e7e\u6d69\u9f0e\u751f\u6280\uff08OBI Pharma\uff09\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u79ef\u6781\u7814\u53d1\u7684\u6297\u764c\u65b0\u836fOBI-3424\u83b7\u5f97\u7f8e\u56fdFDA\u9881\u53d1\u7684\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cOBI-3424\u662f\u4e00\u6b3efirst-in-class\u7684\u4ee5\u8fc7\u8868\u8fbe\u919b\u916e\u8fd8\u539f\u91761C3\uff08AKR1C3\uff09\u4e3a\u6807\u9776\u7684DNA\u70f7\u5316\u764c\u75c7\u6cbb\u7597\u836f\u7269\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">7\u30017\u67088\u65e5\u665a\uff0c\u666f\u5cf0\u533b\u836f\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u5b50\u516c\u53f8\u8d35\u5dde\u666f\u5cf0\u6ce8\u5c04\u5242\u6709\u9650\u516c\u53f8\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u76d0\u9178\u66ff\u7f57\u975e\u73ed\u6ce8\u5c04\u7528\u6d53\u6eb6\u6db2\u300a\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\u300b\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">8\u30017\u670812\u65e5\uff0c\u57fa\u77f3\u836f\u4e1a\u5ba3\u5e03\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1\uff08PD-1\uff09\u6297\u4f53CS1003\u6ce8\u5c04\u6db2\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">9\u30017\u670811\u65e5\u665a\u95f4\uff0c\u590d\u661f\u533b\u836f\u53d1\u5e03\u516c\u544a\uff0c\u8fd1\u65e5\uff0c\u63a7\u80a1\u5b50\u516c\u53f8\u6c5f\u82cf\u4e07\u90a6\u751f\u5316\u533b\u836f\u96c6\u56e2\u6709\u9650\u8d23\u4efb\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5173\u4e8e\u540c\u610f\u4e07\u683c\u5217\u51c0\u7247\u7528\u4e8e\u2161\u578b\u7cd6\u5c3f\u75c5\u9002\u5e94\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">10\u3001\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u6297\u827e\u6ecb\u75c5\u65b0\u836f\u827e\u535a\u97e6\u6cf0\u957f\u6548\u6ce8\u5c04\u5242\u83b7\u6279\u51c6\u4e0a\u5e02\u3002\u8fd9\u4e5f\u662f\u6211\u56fd\u9996\u4e2a\u6297\u827e\u6ecb\u75c5\u957f\u6548\u878d\u5408\u6291\u5236\u5242\uff0c\u8be5\u836f\u7684\u4e0a\u5e02\u8868\u660e\u6211\u56fd\u6297\u827e\u836f\u7269\u5b9e\u73b0\u4e86\u96f6\u7684\u7a81\u7834\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 1.2em;overflow: hidden !important;box-sizing: border-box;\">\n<section style=\"width: 18px;height: 10px;border-radius: 50%;background: #42c463;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-top: 1px dashed #42c463;border-bottom: 1px dashed #42c463;border-right-color: #42c463;border-left-color: #42c463;margin: 0.5em 2px 0.5em;padding-top: 2px;padding-bottom: 2px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 1.2em;overflow: hidden !important;box-sizing: border-box;\">\n<section style=\"width: 18px;height: 10px;border-radius: 50%;background: #42c463;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">1\u3001\u8fd1\u65e5\uff0c\u4e00\u7bc7\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Infection and Immunity\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u58a8\u5c14\u672c\u6c83\u5c14\u7279\u548c\u4f0a\u4e3d\u838e-\u970d\u5c14\u533b\u5b66\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u9ad8\u6c34\u5e73\u7684\u6076\u6027\u759f\u539f\u866b\u6297\u4f53\u6216\u80fd\u5e2e\u52a9\u5df4\u5e03\u4e9a\u65b0\u51e0\u5185\u4e9a\u7684\u513f\u7ae5\u6709\u6548\u62b5\u5fa1\u4e25\u91cd\u7684\u759f\u75be\u611f\u67d3\uff0c\u5982\u679c\u513f\u7ae5\u673a\u4f53\u4e2d\u6709\u9488\u5bf9\u6076\u6027\u759f\u539f\u866b\u7279\u6b8a\u77ed\u94fe\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u9ad8\u6c34\u5e73\u6297\u4f53\u7684\u8bdd\uff0c\u90a3\u4e48\u5176\u5728\u4e34\u5e8a\u4e0a\u7684\u53d1\u75c5\u7387\u6216\u8bb8\u4f1a\u660e\u663e\u964d\u4f4e\u3002<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">2\u3001\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6b66\u6c49\u75c5\u6bd2\u7814\u7a76\u6240\u7f57\u654f\u534e\u8bfe\u9898\u7ec4\u5728\u5be8\u5361\u75c5\u6bd2\uff08ZIKV\uff09\u81f4\u795e\u7ecf\u635f\u4f24\u673a\u5236\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u65b0\u8fdb\u5c55\uff0c\u53d1\u73b0\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u795e\u7ecf\u5e72\u7ec6\u80de\u65f6\u663e\u7740\u4e0b\u8c03\u5176\u91cd\u8981\u6807\u5fd7\u5206\u5b50\u53cc\u76ae\u8d28\u7d20\uff08doublecortin\uff0cDCX\uff09\uff0c\u4e3a\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u5f71\u54cd\u8111\u76ae\u5c42\u7ed3\u6784\u548c\u5927\u8111\u795e\u7ecf\u53d1\u80b2\u63d0\u51fa\u65b0\u7684\u6f5c\u5728\u673a\u5236\u3002\u8be5\u5de5\u4f5c\u5728\u7ebf\u53d1\u8868\u4e8eFrontiers in Micorbiology\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">3\u3001\u8fd1\u671f\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5408\u80a5\u7269\u8d28\u79d1\u5b66\u7814\u7a76\u9662\u533b\u5b66\u7269\u7406\u4e0e\u6280\u672f\u4e2d\u5fc3\u7814\u7a76\u5458\u65b9\u5fd7\u53cb\u8bfe\u9898\u7ec4\u5728\u809d\u764c\u5fae\u73af\u5883\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u65b0\u8fdb\u5c55\uff0c\u76f8\u5173\u7ed3\u679c\u4ee5Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA\/ROCK-ERK\/p38 pathway \u4e3a\u9898\u53d1\u8868\u5728\u80bf\u7624\u5b66\u671f\u520aJournal of Experimental &amp; Clinical Cancer Research\uff08doi\uff1a 10.1186\/s13046-018-0787-2.\uff09\u4e0a\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><img class=\"\"        style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532924046.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c25\u671f\"  \/><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">4\u3001\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6b66\u6c49\u7269\u7406\u4e0e\u6570\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u6768\u4fca\u56e2\u961f\u548c\u534e\u5357\u7406\u5de5\u5927\u5b66\u6559\u6388\u738b\u83ca\u82b3\u56e2\u961f\u5408\u4f5c\uff0c\u5728\u6c34\u901a\u9053\u86cb\u767d\u7684\u95e8\u63a7\u5206\u5b50\u673a\u5236\u65b9\u9762\u53d6\u5f97\u65b0\u8fdb\u5c55\u3002\u4ed6\u4eec\u5728\u529f\u80fd\u6d3b\u6027\u72b6\u6001\u4e0b\u5bf9\u6c34\u901a\u9053\u86cb\u767dAqpZ\u5173\u952e\u201c\u95e8\u63a7\u201d\u6b8b\u57fa\u7684\u7ed3\u6784\u3001\u52a8\u529b\u5b66\u4ee5\u53ca\u6c34\u5206\u5b50\u63a5\u8fd1\u6027\u8fdb\u884c\u7814\u7a76\uff0c\u63ed\u793a\u4e86\u6c34\u901a\u9053\u86cb\u767dAqpZ\u7684\u6c34\u5206\u5b50\u901a\u9053\u5904\u4e8e\u201c\u6c38\u4e45\u5f00\u653e\u201d\u72b6\u6001\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57286\u670827\u65e5\u7684\u300a\u7f8e\u56fd\u5316\u5b66\u4f1a\u5fd7\u300b\uff08Journal of the American Chemical Society\uff09\u6742\u5fd7\u4e0a\uff08\u5185\u5c01\u9762\uff09\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\">\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">5\u30017\u67084\u65e5\u7535\uff0c\u8bb0\u8005\u8fd1\u65e5\u4ece\u5409\u6797\u5927\u5b66\u4e86\u89e3\u5230\uff0c\u5409\u6797\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u6559\u6388\u5218\u5c0f\u6ce2\u56e2\u961f\u4ece\u5411\u65e5\u8475\u82b1\u76d8\u63d0\u53d6\u51fa\u6297\u75db\u98ce\u6709\u6548\u6210\u5206\u3002\u8fd9\u4e00\u6210\u679c\u5df2\u5728\u300a\u533b\u836f\u536b\u751f\u300b\u7b49\u56fd\u5185\u4e13\u4e1a\u533b\u5b66\u520a\u7269\u53d1\u8868\uff0c\u5e76\u83b7\u5f97\u4e24\u9879\u56fd\u5bb6\u53d1\u660e\u4e13\u5229\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">6\u3001\u950c\u6307\u86cb\u767dSnail\u662f\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u7684\u4e00\u4e2a\u4e3b\u8981\u8c03\u63a7\u56e0\u5b50\uff0c\u4e5f\u662f\u80bf\u7624\u8f6c\u79fb\u7684\u91cd\u8981\u8bf1\u5bfc\u56e0\u7d20\uff0c\u4f46Snail\u89e6\u53d1\u7684\u4fe1\u53f7\u7ea7\u8054\u8fc7\u7a0b\u8fd8\u6ca1\u6709\u5f97\u5230\u5b8c\u5168\u63ed\u793a\u3002\u6700\u8fd1\u6765\u81ea\u4e0a\u6d77\u751f\u79d1\u9662\u3001\u5927\u8fde\u533b\u79d1\u5927\u5b66\u548c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u7b49\u5355\u4f4d\u7684\u7814\u7a76\u4eba\u5458\u5728\u56fd\u9645\u5b66\u672f\u671f\u520aCell Death\uff06Differentiation\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u4ed6\u4eec\u5728\u8be5\u7814\u7a76\u4e2d\u63ed\u793a\u4e86Snail\u8bf1\u5bfc\u4e73\u817a\u764c\u7ec6\u80de\u8f6c\u79fb\u7684\u91cd\u8981\u673a\u5236\u3002<\/span><\/p>\n<p style=\"line-height: 2em;margin-bottom: 10px;text-align: justify;\"><span 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