{"id":130438,"date":"2019-12-31T03:00:15","date_gmt":"2020-04-21T02:54:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/130438\/"},"modified":"2020-04-21T10:54:03","modified_gmt":"2020-04-21T02:54:03","slug":"38f4c1a804","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/130438\/","title":{"rendered":"DAA \u964d\u4ef7 85% \u8fdb\u533b\u4fdd\uff0c\u5faa\u8bc1\u53ca\u6307\u5357\u63a8\u8350\u901f\u89c8"},"content":{"rendered":"
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2019 \u5e74 11 \u6708 28 \u65e5\uff0c\u4f17\u4eba\u7fd8\u9996\u4ee5\u76fc\u7684\u300c\u5c06 2019 \u5e74\u8c08\u5224\u836f\u54c1\u7eb3\u5165\u300a\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u300b\u8303\u56f4\u7684\u901a\u77e5\u300d\u5728\u56fd\u5bb6\u533b\u7597\u4fdd\u969c\u5c40\uff08\u4e0b\u79f0\u533b\u4fdd\u5c40\uff09\u5b98\u7f51\u91cd\u78c5\u516c\u5e03\uff0c\u6700\u65b0\u4e00\u6279\u901a\u8fc7\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u51c6\u5165\u8c08\u5224\u7684\u836f\u54c1\u540d\u5355\u516c\u5e03\uff0c\u5171\u8ba1 97 \u79cd\u3002\u5728\u65b0\u589e\u7684 70 \u4e2a\u836f\u54c1\u540d\u5355\u4e2d\uff0c\u4e09\u79cd\u4e19\u809d\u76f4\u63a5\u6297\u75c5\u6bd2\u836f\u7269\uff08DAA\uff09\u9996\u6b21\u88ab\u7eb3\u5165\uff0c\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7247\uff08\u590f\u5e06\u5b81<\/span>\u00ae<\/sup>\uff09\u3001\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7247\uff08\u4e19\u901a\u6c99<\/span>\u00ae<\/sup>\uff09\u4f4d\u5217\u5176\u4e2d\u3002\u636e\u533b\u4fdd\u5c40\u5b98\u7f51\u540c\u671f\u53d1\u5e03\u7684\u653f\u7b56\u89e3\u8bfb\uff0c\u6b64\u6b21\u533b\u4fdd\u836f\u54c1\u51c6\u5165\u8c08\u5224\uff0c\u80fd\u6cbb\u6108\u4e19\u809d\u7684 DAA \u5907\u53d7\u5173\u6ce8\u3002\u8c08\u5224\u6210\u529f\u540e\uff0c\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u3001\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7b49 DAA \u7684\u4ef7\u683c\u964d\u5e45\u4f4d\u5c45\u6240\u6709\u836f\u7269\u4e4b\u9996\uff0c\u9ad8\u8fbe 85% \u4ee5\u4e0a\uff0c\u5207\u5b9e\u4e3a\u6211\u56fd\u5e7f\u5927\u4e19\u809d\u60a3\u8005\u5927\u5e45\u964d\u4f4e\u4e86\u7ecf\u6d4e\u8d1f\u62c5\u3002
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\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u3001\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u4e24\u79cd DAA \u4e8e 2018 \u5e74\u5728\u6211\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u4e0d\u540c\u7c7b\u578b\u7684\u6162\u6027\u4e19\u809d\u60a3\u8005\uff0c\u4ee5\u4e0b\u5c06\u56de\u987e\u5176\u5173\u952e\u7684\u4e34\u5e8a\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u53ca\u5168\u7403\u5404\u5927\u4e19\u578b\u809d\u708e\u6307\u5357\u5bf9\u4e24\u79cd\u836f\u7269\u7684\u6cbb\u7597\u63a8\u8350\uff0c\u5e0c\u671b\u5bf9\u5927\u5bb6\u7684\u4e34\u5e8a\u5b9e\u8df5\u6709\u6240\u52a9\u76ca\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\uff1a<\/span><\/strong>\u5bf9\u57fa\u56e0 1\uff5e6 \u578b\u3001\u6df7\u5408\u578b\u3001\u65e0\u6cd5\u786e\u5b9a\u57fa\u56e0\u578b\u6162\u4e19\u809d\u60a3\u8005\uff0c\u603b\u4f53\u6cbb\u6108\u7387\uff08SVR12\uff09\u9ad8\u8fbe 98%<\/span><\/strong><\/span><\/section>\n

<\/span><\/strong><\/span><\/section>\n
<\/section>\n
<\/section>\n
\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u4f5c\u4e3a\u552f\u4e00\u8fdb\u5165 2019 \u533b\u4fdd\u76ee\u5f55\u7684\u6cdb\u57fa\u56e0\u578b DAA \u836f\u7269 <\/span>1<\/sup>\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6162\u6027\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\u611f\u67d3 2<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

ASTRAL \u7cfb\u5217\u56fd\u9645\u591a\u4e2d\u5fc3 III \u671f\u4e34\u5e8a\u7814\u7a76\u5960\u5b9a\u4e86\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7684\u4f5c\u4e3a\u6cdb\u57fa\u56e0\u578b DAA \u4e34\u5e8a\u5e94\u7528\u57fa\u7840\uff08\u8868 1\uff09\u3002<\/span><\/section>\n

<\/section>\n
\"DAA<\/section>\n

\u8868 1  ASTRAL \u7cfb\u5217\u7814\u7a76\u5165\u7ec4\u4eba\u7fa4\u53ca\u5206\u7ec4\u60c5\u51b5 2<\/sup><\/span><\/span><\/p>\n


<\/p>\n

ASTRAL-1\u3001ASTRAL-2\u3001ASTRAL-3 \u7814\u7a76\u5171\u8ba1\u7eb3\u5165 1035 \u4f8b\u65e0\u809d\u786c\u5316\/\u4f34\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684\u57fa\u56e0 1\uff5e6 \u578b HCV \u611f\u67d3\u7684\u521d\u6cbb\u60a3\u8005\u548c\u7ecf\u6cbb\u60a3\u8005\uff0c\u90fd\u63a5\u53d7\u4e86 12 \u5468\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u6cbb\u7597\uff08\u4e0d\u52a0\u7528\u5229\u5df4\u97e6\u6797\uff09\u3002\u6c47\u603b\u7684\u7ed3\u679c\u663e\u793a\uff0c 12 \u5468\u6301\u7eed\u75c5\u6bd2\u5b66\u5e94\u7b54\u7387\uff08SVR12\uff09\u603b\u4f53\u9ad8\u8fbe 98%\uff081015\/1035\uff093<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

ASTRAL-4 \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u8054\u5408 RBV 12 \u5468\u6cbb\u7597\u57fa\u56e0 1\uff5e6 \u578b\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\uff08Child-Pugh B \u7ea7\uff09\u60a3\u8005\uff0cSVR12 \u8fbe 94%\uff0882\/87\uff094<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

ASTRAL-5 \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c95%\uff08101\/106\uff09\u7684 HCV\/HIV-1 \u5408\u5e76\u611f\u67d3\u60a3\u8005\u63a5\u53d7 12 \u5468\u7684\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u6cbb\u7597\u5b9e\u73b0\u4e86SVR12 5<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

\u9b4f\u6765\u6559\u6388\u7275\u5934\u5728\u6211\u56fd\u5f00\u5c55\u7684\u4e00\u9879 III \u671f\u4e34\u5e8a\u7814\u7a76\u8bc4\u4f30\u4e86\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7528\u4e8e\u4e2d\u56fd\u57fa\u56e0 1\uff5e6 \u578b HCV \u611f\u67d3\uff08\u65e0\u809d\u786c\u5316\u6216\u4f34\u4ee3\u507f\u671f\u809d\u786c\u5316\uff09\u521d\u6cbb\u548c\u7ecf\u6cbb\u60a3\u8005\u7684\u5b89\u5168\u6027\u4e0e\u7597\u6548\uff08n = 264\uff09\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u60a3\u8005\u4eba\u7fa4\u7684\u603b SVR12 \u7387\u4e3a 96%\uff08254\/264\uff09\u3002\u5176\u4e2d\u4e0d\u540c\u57fa\u56e0\u578b\u7684 SVR12 \u5206\u522b\u4e3a\uff1a1b \u578b 100%\uff0882\/82\uff09\u30012 \u578b 100%\uff0861\/61\uff09\u30013 \u578b 83%\uff0849\/59\uff09\u548c 6 \u578b 100%\uff0862\/62\uff09\u3002DAA \u65f6\u4ee3\u96be\u6cbb\u7684\u57fa\u56e0 3 \u578b\u60a3\u8005\u9664 GT3b \u5408\u5e76\u4ee3\u507f\u671f\u809d\u786c\u5316\u60a3\u8005\u5916\uff0cSVR12 \u90fd\u5728 90% \u4ee5\u4e0a 6<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u672a\u53d1\u751f 3-4 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u65e0\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u505c\u6b62\u6cbb\u7597\uff0c\u672a\u51fa\u73b0\u6b7b\u4ea1\uff0c\u53d1\u751f\u7387\u02c310% \u7684\u4e0d\u826f\u4e8b\u4ef6\u53ea\u6709\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0810%\uff096<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

\u8fd9\u4e00\u7814\u7a76\u9a8c\u8bc1\u4e86\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u5728\u6211\u56fd\u57fa\u56e0 1\uff5e6 \u578b HCV \u611f\u67d3\u60a3\u8005\u7684\u9ad8\u6548\u6027\u4e0e\u5b89\u5168\u6027 6<\/sup>\u3002<\/span><\/section>\n

<\/section>\n

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\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\uff1a<\/span><\/strong><\/strong><\/section>\n
\u5bf9\u4e2d\u56fd\u57fa\u56e0 1b \u578b\u6162\u6027\u4e19\u809d\u60a3\u8005\u6cbb\u6108\u7387\uff08SVR12\uff09100%<\/span><\/strong><\/strong><\/strong><\/section>\n
<\/section>\n


<\/p>\n

\u5728\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u83b7\u6279\u540e\u534a\u5e74\uff0c\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u5728\u6211\u56fd\u4e5f\u6210\u529f\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u57fa\u56e0 1\u30012\u30014\u30015\u30016 \u578b\u6210\u4eba\u548c 12 \u81f3<18 \u5c81\u9752\u5c11\u5e74\u7684\u6162\u6027\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\u611f\u67d3 <\/span>7<\/sup>\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7684\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e 0131 \u7814\u7a76\uff0c\u8be5\u7814\u7a76\u662f\u4e00\u9879\u4e2d\u56fd\u591a\u4e2d\u5fc3 III \u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4e3b\u8981\u5728\u4f34\u6216\u4e0d\u4f34\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684\u57fa\u56e0 1b \u578b HCV \u611f\u67d3\uff08\u521d\u6cbb\u6216\u7ecf\u6cbb\uff09\u60a3\u8005\u4e2d\u8bc4\u4f30\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff0c\u5176\u4e2d\u7eb3\u5165\u4e86\u6765\u81ea\u4e2d\u56fd 18 \u5bb6\u7814\u7a76\u4e2d\u5fc3\u7684 206 \u4f8b\u60a3\u8005 8<\/sup>\u3002<\/span><\/section>\n


<\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4f7f\u7528\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u6cbb\u7597 12 \u5468\uff08\u4e0d\u52a0\u7528\u5229\u5df4\u97e6\u6797\uff09\uff0c\u6240\u6709 206 \u4f8b\u4e2d\u56fd\u60a3\u8005\uff08100%\uff09\u5747\u5b9e\u73b0\u4e86 SVR12\u3002<\/span><\/section>\n

<\/section>\n
\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u672a\u53d1\u751f 3-4 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u65e0\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u505c\u6b62\u6cbb\u7597\uff0c\u672a\u51fa\u73b0\u6b7b\u4ea1\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u75c5\u6bd2\u6027\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0817%\uff09\u3002<\/span><\/section>\n


<\/p>\n

\u8fd9\u4e00\u7814\u7a76\u8bc1\u660e\u4e86\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u5728\u6211\u56fd GT1b \u578b\u60a3\u8005\u4e2d\u5177\u6709\u9ad8\u6cbb\u6108\u7387\u548c\u826f\u597d\u7684\u5b89\u5168\u6027 8<\/sup>\u3002<\/span><\/section>\n

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\u5168\u7403\u5404\u5927\u6307\u5357\u9002\u65f6\u66f4\u65b0\uff0c\u5bf9\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u3001\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7684\u5e94\u7528\u7ed9\u4e88\u6743\u5a01\u6307\u5bfc<\/span><\/strong><\/strong><\/section>\n

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<\/section>\n
\u968f\u7740\u591a\u79cd DAA \u836f\u7269\u83b7\u6279\u7528\u4e8e\u4e34\u5e8a\uff0c\u5168\u7403\u5404\u5927\u6307\u5357\u5728\u8fd1\u671f\u5185\u8fdb\u884c\u4e86\u5bc6\u96c6\u66f4\u65b0\uff0c\u4e3a\u4e34\u5e8a\u7528\u836f\u63d0\u4f9b\u4e86\u5207\u5b9e\u6307\u5bfc\uff0c\u5176\u4e2d\u5bf9\u4e8e\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u3001\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7684\u5177\u4f53\u63a8\u8350\u5982\u4e0b\u8868 2 \u6240\u793a\u3002<\/span><\/section>\n

<\/section>\n
\"DAA<\/section>\n

\u8868 2  \u6307\u5357\u5bf9\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u3001\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7684\u5e94\u7528\u63a8\u8350 <\/span>9\u00b710<\/sup><\/span><\/p>\n

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\u5927\u5e45\u964d\u4ef7\u8fdb\u5165\u533b\u4fdd\uff0c\u52a9\u529b\u4e2d\u56fd\u5b9e\u73b0\u6d88\u9664\u4e19\u809d\u76ee\u6807<\/strong><\/span><\/strong><\/strong><\/section>\n
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\u8d23\u7f16\uff1akendy<\/span><\/p>\n

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\u6b22\u8fce\u5411\u62a5\u6599\uff01<\/span><\/em><\/span>\u8bf7\u52a0\u5fae\u4fe1\uff1a<\/span><\/em>dxylzzb<\/span><\/em><\/span><\/section>\n

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\u9898\u56fe\u6765\u6e90\uff1a\u7ad9\u9177\u6d77\u6d1bPLUS<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

1.\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55.\uff08\u533b\u4fdd\u53d1\u30142019\u301565 \u53f7\uff09<\/span><\/span><\/p>\n

2.\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7247\u8bf4\u660e\u4e66.  \u6838\u51c6\u65e5\u671f 2018 \u5e74 5 \u6708 23 \u65e5.<\/span><\/span><\/p>\n

3.Agarwal K, et al. ILC 2016; Poster #SAT-195<\/span><\/span><\/p>\n

4.Lim\uff0cet al, APASL 2017, OP146<\/span><\/span><\/p>\n

5.Curry et al. N Engl J Med. 2015;373(27):2618-28.<\/span><\/span><\/p>\n

6.Wyles D,et al.Clin Infect Dis. 2017 Jul 1;65(1):6-12.<\/span><\/span><\/p>\n

7.Lai W,et al. AASLD 2018.Poster637.<\/span><\/span><\/p>\n

8.\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7247\u8bf4\u660e\u4e66. \u6838\u51c6\u65e5\u671f\uff1a<\/span><\/span>2018 \u5e74 11 \u6708 21 \u65e5.<\/span><\/p>\n

9.Wei L,et al.Hepatol Int. 2018 Mar;12(2)126-132.<\/span><\/span><\/p>\n

10.EASL. EASL Recommendations on Treatment of Hepatitis C 2018. J Hepatol, 2018.<\/span><\/span><\/p>\n

11.AASLD\/IDSA\/IAS\u2013USA. Recommendations for testing, managing, and treating hepatitis C. http:\/\/www.hcvguidelines.org. Accessed Nov, 2019.Polaris Observatory HCV Collaborators. Lancet Gastroenterol  Hepatol. 2017;2161-176<\/span><\/span><\/p>\n<\/section>\n


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