{"id":132107,"date":"2020-01-26T12:04:00","date_gmt":"2020-04-21T03:09:08","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/132107\/"},"modified":"2020-04-21T11:09:11","modified_gmt":"2020-04-21T03:09:11","slug":"cbb0cfc2a9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/132107\/","title":{"rendered":"\u6cbb\u7597\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff0c\u65b0\u836f\u5f00\u53d1\u4e3a\u4ec0\u4e48\u90a3\u4e48\u96be\uff1f"},"content":{"rendered":"
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\u4e09\u5927\u7b56\u7565\u5f00\u53d1\u65b0\u836f<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9b\u7597\u6cd5\u7684\u4f18\u70b9\u5728\u4e8e\u65e9\u5df2\u83b7\u6279\u4e0a\u5e02\uff0c\u6cbb\u7597\u4e0d\u540c\u7684\u75c5\u6bd2\u611f\u67d3\uff0c\u56e0\u6b64\u5176\u5728\u4eba\u4f53\u5185\u7684\u4ee3\u8c22\u7279\u5f81\uff0c\u4f7f\u7528\u7684\u5242\u91cf\uff0c\u6f5c\u5728\u7684\u7597\u6548\u548c\u526f\u4f5c\u7528\u90fd\u5f88\u660e\u786e\u3002<\/span>\u4f46\u7f3a\u70b9\u5728\u4e8e\u8fd9\u4e9b\u7597\u6cd5\u8fc7\u4e8e\u300c\u5e7f\u8c31\u300d\uff0c\u4e0d\u80fd\u9488\u5bf9\u6027\u5730\u6cbb\u7597\u51a0\u72b6\u75c5\u6bd2\u3002<\/span><\/strong><\/span><\/strong>\u6b64\u5916\uff0c\u5176\u526f\u4f5c\u7528\u4e5f\u4e0d\u5bb9\u5c0f\u89c6\u3002<\/span><\/strong><\/span><\/p>\n


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\u4f46 Nature Reviews Drug Discovery<\/em> \u7684\u7efc\u8ff0\u4e5f\u63d0\u5230\uff0c<\/span>\u5c3d\u7ba1\u8bb8\u591a\u836f\u7269\u5728\u4f53\u5916\u5c55\u73b0\u51fa\u4e86\u826f\u597d\u7684\u6297\u51a0\u72b6\u75c5\u6bd2\u6d3b\u6027\uff0c\u4f46\u5f80\u5f80\u4e0d\u5177\u6709\u4eba\u4f53\u5185\u5e94\u7528\u7684\u4ef7\u503c\u3002<\/span><\/strong>\u539f\u56e0\u4e00\u65b9\u9762\u662f\u56e0\u4e3a\u53ef\u80fd\u4f1a\u5e26\u6765\u514d\u75ab\u529b\u6291\u5236\u7684\u526f\u4f5c\u7528\uff0c\u53e6\u4e00\u65b9\u9762\u5219\u662f\u56e0\u4e3a\u836f\u7269\u8d77\u6548\u6240\u9700\u7684\u6d53\u5ea6\uff0c\u5f80\u5f80\u4f1a\u8d85\u8fc7\u8840\u6e05\u836f\u7269\u6d53\u5ea6\u7684\u4e0a\u9650\u3002<\/span><\/p>\n


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\"\u6cbb\u7597\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff0c\u65b0\u836f\u5f00\u53d1\u4e3a\u4ec0\u4e48\u90a3\u4e48\u96be\uff1f\"\u9488\u5bf9\u51a0\u72b6\u75c5\u6bd2\u7684\u57fa\u56e0\u7ec4\uff0c\u6211\u4eec\u6709\u671b\u627e\u5230\u591a\u79cd\u4e0d\u540c\u7684\u9776\u70b9\uff08<\/span>\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/p>\n


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\u7406\u8bba\u4e0a\u8bf4\uff0c\u8fd9\u4e9b\u7597\u6cd5\u7684\u6297\u51a0\u72b6\u75c5\u6bd2\u6548\u679c\u4f1a\u66f4\u80dc\u4e00\u7b79\uff0c\u4f46\u5b83\u9700\u8981\u9a8c\u8bc1\u4e0d\u540c\u836f\u7269\u5728\u4eba\u4f53\u4e2d\u7684\u4ee3\u8c22\u60c5\u51b5\u548c\u526f\u4f5c\u7528\uff0c\u4e5f\u9700\u8981\u4f9d\u6b21\u5f00\u5c55\u52a8\u7269\u548c\u4eba\u7c7b\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u89c2\u5bdf\u662f\u5426\u5b89\u5168\u6709\u6548\u3002<\/span>\u8fd9\u4e00\u5957\u6d41\u7a0b\u9700\u8981\u8017\u8d39\u6570\u5e74\uff0c\u4e43\u81f3 10 \u591a\u5e74\u7684\u65f6\u95f4\u3002<\/span>\u5bf9\u4e8e\u6025\u6027\u7206\u53d1\u7684\u75be\u75c5\u800c\u8a00\uff0c\u663e\u7136\u662f\u300c\u8fdc\u6c34\u6551\u4e0d\u4e86\u8fd1\u706b\u300d\u3002<\/span><\/strong><\/p>\n


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\u8fc7\u53bb\u6709\u54ea\u4e9b\u6f5c\u5728\u7597\u6cd5\uff1f<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u65b9\u9762\uff0c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u53cd\u5e94\u5bf9\u63a7\u5236\u51a0\u72b6\u75c5\u6bd2\u7684\u590d\u5236\u548c\u611f\u67d3\u6709\u7740\u5f88\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u800c\u5e72\u6270\u7d20\u6709\u671b\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n


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\u8003\u8651\u5230\u51a0\u72b6\u75c5\u6bd2\u5f80\u5f80\u4f1a\u6291\u5236\u5e72\u6270\u7d20\u7684\u6548\u679c\uff0c\u63d0\u4f9b\u91cd\u7ec4\u5e72\u6270\u7d20\uff0c\u6216\u662f\u63d0\u4f9b\u5e72\u6270\u7d20\u8bf1\u5bfc\u5242\uff0c\u53ef\u80fd\u662f\u4e00\u4e2a\u5bf9\u7b56\u3002\u53e6\u5916\uff0c\u5e72\u6270\u7d20\u4e0e\u5229\u5df4\u97e6\u6797\u8054\u7528\uff0c\u6216\u662f\u4e0e HIV \u611f\u67d3\u836f\u7269\u6d1b\u5339\u90a3\u97e6\/\u5229\u6258\u90a3\u97e6\u8054\u7528\uff0c\u4e5f\u66fe\u89c1\u4e8e SARS \u548c MERS \u4e24\u79cd\u51a0\u72b6\u75c5\u6bd2\u7684\u6cbb\u7597\u3002<\/span><\/p>\n


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\"\u6cbb\u7597\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\uff0c\u65b0\u836f\u5f00\u53d1\u4e3a\u4ec0\u4e48\u90a3\u4e48\u96be\uff1f\"\u9488\u5bf9\u4eba\u4f53\u7684\u90e8\u5206\u6f5c\u5728\u7597\u6cd5\uff08<\/span>\u6570\u636e\u6765\u6e90\uff1a<\/span>\u53c2\u8003\u8d44\u6599[1] <\/span>\u5236\u56fe\uff1a<\/span>\u5185\u5bb9\u56e2\u961f\uff0c<\/span>\u6ce8\uff1a<\/span>\u672c\u8868\u683c\u4ec5\u4f5c\u4fe1\u606f\u5206\u4eab\uff0c\u4e0d\u662f\u6cbb\u7597\u65b9\u6cd5\u63a8\u8350\u3002<\/span>\u5b8c\u6574\u8868\u683c\u8bf7\u8bbf\u95ee\u53c2\u8003\u8d44\u6599[1]\uff1b<\/span>2016 \u5e74\u540e\u7684\u6570\u636e\u672a\u6536\u5f55\uff09<\/span><\/p>\n


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\u4e0d\u8fc7\u5728\u8fd9\u7bc7 Nature Reviews Drug Discovery<\/em> \u7684\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u4e5f\u63d0\u5230\uff0c\u5e72\u6270\u7d20\u4e0e\u5229\u5df4\u97e6\u6797\u7684\u8054\u5408\u7597\u6cd5\uff0c\u5176\u6548\u679c\u5e76\u4e0d\u7a33\u5b9a\u3002\u80cc\u540e\u7684\u539f\u56e0\u53ef\u80fd\u662f\u7b49\u5230\u75c7\u72b6\u53d1\u4f5c\u540e\uff0c\u60a3\u8005\u624d\u4f1a\u63a5\u53d7\u6cbb\u7597\u3002<\/span><\/p>\n


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\u53e6\u5916\uff0c\u75c5\u6bd2\u4e3a\u4e86\u8fdb\u5165\u4eba\u4f53\u7ec6\u80de\uff0c\u5f80\u5f80\u4f1a\u7ed3\u5408\u5230\u4e00\u4e9b\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u86cb\u767d\u4e0a\u3002\u8b6c\u5982 SARS \u75c5\u6bd2\u7ed3\u5408\u7684\u662f ACE2 \u53d7\u4f53\uff0c\u800c MERS \u7ed3\u5408\u7684\u662f DPP4 \u53d7\u4f53\u3002\u5148\u524d\uff0c\u4eba\u4eec\u5df2\u7ecf\u9488\u5bf9\u8fd9\u4e9b\u53d7\u4f53\uff0c\u5f00\u53d1\u4e86\u4e00\u4e9b\u5728\u7814\u7684\u836f\u7269\uff0c\u5176\u4e2d\u4e00\u4e9b\u7684\u5b89\u5168\u6027\u5df2\u7ecf\u5f97\u5230\u4e86\u8bc4\u4f30\u3002\u5728\u6291\u5236\u51a0\u72b6\u75c5\u6bd2\u65b9\u9762\uff0c\u5b83\u4eec\u7684\u6548\u679c\u4e5f\u503c\u5f97\u671f\u5f85\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1]<\/span> Zumla, A., Chan, J., Azhar, E. et al. Coronaviruses \u2014 drug discovery and therapeutic options. Nat Rev Drug Discov 15, 327\u2013347 (2016). <\/span><\/p>\n

https:\/\/doi.org\/10.1038\/nrd.2015.37<\/span><\/p>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n
<\/span><\/span><\/strong><\/span><\/span><\/section>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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