{"id":132313,"date":"2020-01-29T13:58:10","date_gmt":"2020-04-21T03:11:04","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/132313\/"},"modified":"2020-04-21T11:11:07","modified_gmt":"2020-04-21T03:11:07","slug":"da866c661d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/132313\/","title":{"rendered":"\u91cd\u8981\u6570\u636e | \u4e2d\u56fd\u56e2\u961f\u5728 NEJM \u53d1\u5e03\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7814\u7a76"},"content":{"rendered":"
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2019 \u5e74 12 \u6708\uff0c\u4e2d\u56fd\u6b66\u6c49\u51fa\u73b0\u4e86\u4e00\u7fa4\u4e0e\u6d77\u9c9c\u6279\u53d1\u5e02\u573a\u6709\u5173\u7684\u4e0d\u660e\u539f\u56e0\u5bfc\u81f4\u7684\u80ba\u708e\u60a3\u8005\u3002\u901a\u8fc7\u5bf9\u80ba\u708e\u60a3\u8005\u7684\u6837\u672c\u8fdb\u884c\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u53d1\u73b0\u4e86\u4e00\u79cd\u4ece\u672a\u89c1\u8fc7\u7684\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u5c5e\uff08betacoronavirus\uff09\u75c5\u6bd2\u3002<\/span><\/section>\n

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\u8be5\u75c5\u6bd2\u4ece\u611f\u67d3\u8005\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u4e2d\u5206\u79bb\u51fa\uff0c\u968f\u540e\u5c06\u5176\u547d\u540d\u4e3a 2019-nCoV\uff0c\u8fd9\u79cd\u75c5\u6bd2\u5f52\u5c5e\u4e8e Sarbe \u75c5\u6bd2\u4e9a\u5c5e\uff0c\u6b63\u51a0\u72b6\u75c5\u6bd2\u4e9a\u79d1\uff0c\u4f46\u5f62\u6210\u4e86\u53e6\u5916\u4e00\u7c07\u7684\u8fdb\u5316\u5206\u679d\u3002<\/span><\/section>\n

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2019-nCoV \u4e0e MERS-CoV \u548c SARS-CoV \u90fd\u4e0d\u540c\uff0c\u5b83\u6210\u4e3a\u53ef\u4ee5\u611f\u67d3\u4eba\u7c7b\u7684\u51a0\u72b6\u75c5\u6bd2\u79d1\u4e2d\u7684\u7b2c\u4e03\u4e2a\u6210\u5458\u3002\u5bf9\u8be5\u75c5\u6bd2\u7684\u52a0\u5f3a\u76d1\u63a7\u548c\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\uff08\u7531\u4e2d\u56fd\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u9879\u76ee\u548c\u56fd\u5bb6\u4f20\u67d3\u75c5\u9632\u6cbb\u91cd\u5927\u4e13\u9879\u8d44\u52a9\uff09\u3002<\/span>
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\u5df2\u77e5\u6709 6 \u4e2a\u51a0\u72b6\u75c5\u6bd2\u5c5e\u5bf9\u4eba\u7c7b\u81f4\u75c5\uff0c\u5176\u4e2d\u4ee5 229E\u3001OC43\u3001NL63 \u548c HKU1 \u4e3a\u4e3b\uff0c\u53ef\u4ee5\u5bfc\u81f4\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u5bbf\u4e3b\u53d1\u751f\u666e\u901a\u611f\u5192\u75c7\u72b6\uff1b\u53e6\u5916\u4e24\u79cd\u75c5\u6bd2\uff1a\u4e25\u91cd\u6025\u6027\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2\uff08SARS-CoV\uff09\u548c\u4e2d\u4e1c\u547c\u5438\u7efc\u5408\u5f81\u75c5\u6bd2\uff08MERS-CoV\uff09\u662f\u4eba\u755c\u5171\u60a3\u4f20\u67d3\u75c5\uff0c\u6709\u65f6\u4e0e\u81f4\u547d\u75be\u75c5\u6709\u5173\u3002<\/span><\/section>\n

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SARS-CoV \u662f\u4e2d\u56fd\u5e7f\u4e1c 2002 \u5e74\u81f3 2003 \u5e74\u95f4\u66b4\u53d1\u7684\u4e25\u91cd\u6025\u6027\u547c\u5438\u7efc\u5408\u5f81\u7684\u75c5\u539f\uff0c\u800c MERS-CoV \u662f 2012 \u5e74\u4e2d\u4e1c\u5730\u533a\u66b4\u53d1\u7684\u4e25\u91cd\u547c\u5438\u9053\u75be\u75c5\u7684\u75c5\u539f\u3002\u57fa\u4e8e\u51a0\u72b6\u75c5\u6bd2\u7684\u9ad8\u6d41\u884c\u7387\u548c\u5e7f\u6cdb\u5206\u5e03\uff0c\u5176\u57fa\u56e0\u7ec4\u7684\u5de8\u5927\u9057\u4f20\u591a\u6837\u6027\u548c\u9891\u7e41\u91cd\u7ec4\uff0c\u4ee5\u53ca\u4eba-\u52a8\u7269\u95f4\u63a5\u89e6\u6d3b\u52a8\u7684\u589e\u52a0\uff0c\u52a0\u4e4b\u9891\u7e41\u7684\u8de8\u7269\u79cd\u611f\u67d3\u548c\u5076\u5c14\u7684\u52a8\u7269\u4f20\u4eba\u4e8b\u4ef6\uff0c\u65b0\u7684\u51a0\u72b6\u75c5\u6bd2\u53ef\u80fd\u4f1a\u5468\u671f\u6027\u5730\u51fa\u73b0\u5728\u4eba\u7c7b\u9762\u524d\u3002<\/span><\/section>\n

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2019 \u5e74 12 \u6708\u672b\uff0c\u51e0\u5bb6\u5f53\u5730\u536b\u751f\u673a\u6784\u62a5\u544a\u4e86\u4e00\u7ec4\u4e0d\u660e\u539f\u56e0\u7684\u80ba\u708e\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u6d41\u884c\u75c5\u5b66\u4e0a\u4e0e\u6b66\u6c49\u7684\u4e00\u5bb6\u6d77\u9c9c\u548c\u6e7f\u755c\u6279\u53d1\u5e02\u573a\u6709\u5173\u3002<\/span><\/section>\n

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12 \u6708 31 \u65e5\uff0c\u4e2d\u56fd\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3\uff08\u4e2d\u56fd CDC\uff09\u6d3e\u51fa\u5feb\u901f\u5e94\u6025\u5c0f\u7ec4\u4f1a\u540c\u6e56\u5317\u7701\u548c\u6b66\u6c49\u5e02\u536b\u751f\u673a\u6784\u8fdb\u884c\u4e86\u6d41\u884c\u75c5\u5b66\u548c\u75c5\u539f\u5b66\u8c03\u67e5\u3002\u5728\u66b4\u53d1\u7684\u65e9\u671f\uff0c\u6211\u4eec\u62a5\u544a\u4e86\u8fd9\u9879\u8c03\u67e5\u7684\u7ed3\u679c\uff0c\u786e\u5b9a\u4e86\u80ba\u708e\u96c6\u7fa4\u7684\u6765\u6e90\uff0c\u5e76\u63cf\u8ff0\u4e86\u5728\u80ba\u708e\u60a3\u8005\u4e2d\u68c0\u6d4b\u5230\u7684\u4e00\u79cd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u3002\u6211\u4eec\u8fd8\u63cf\u8ff0\u4e86\u5176\u4e2d\u4e24\u540d\u60a3\u8005\u80ba\u708e\u7684\u4e34\u5e8a\u7279\u5f81\u3002<\/span><\/section>\n

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1. \u60a3\u8005\u60c5\u51b5<\/strong><\/span><\/span><\/section>\n

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2019 \u5e74 12 \u6708 27 \u65e5\uff0c\u51fa\u73b0\u4e25\u91cd\u80ba\u708e\u75c7\u72b6\u7684 3 \u540d\u6210\u5e74\u60a3\u8005\u88ab\u6536\u5165\u6b66\u6c49\u4e00\u5bb6\u533b\u9662\u3002\u60a3\u8005 1 \u4e3a 49 \u5c81\u5973\u6027\uff1b\u60a3\u8005 2 \u4e3a 61 \u5c81\u7537\u6027\uff1b\u60a3\u8005 3 \u4e3a 32 \u5c81\u7537\u6027\u3002\u6536\u96c6\u4e86\u60a3\u8005 1 \u548c\u60a3\u8005 2 \u7684\u75c5\u53f2\uff1a\u60a3\u8005 1 \u6ca1\u6709\u6f5c\u5728\u7684\u6162\u6027\u57fa\u7840\u75c5\u53f2\uff0c\u4f46\u4ece 2019 \u5e74 12 \u6708 23 \u65e5\u51fa\u73b0\u53d1\u70ed\uff08\u4f53\u6e29 37~38\u00b0C \uff09\u3001\u54b3\u55fd\u53ca\u80f8\u90e8\u4e0d\u9002\u75c7\u72b6\u3002<\/span>
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\u5728\u4e34\u5e8a\u75c7\u72b6\u51fa\u73b0\u540e 4 \u5929\uff0c\u54b3\u55fd\u548c\u80ba\u90e8\u4e0d\u9002\u75c7\u72b6\u52a0\u91cd\uff0c\u4f46\u53d1\u70ed\u75c7\u72b6\u7f13\u89e3\uff0c\u57fa\u4e8e CT \u626b\u63cf\u7684\u7ed3\u679c\u505a\u4e86\u80ba\u708e\u8bca\u65ad\u3002\u6b64\u60a3\u8005\u7684\u804c\u4e1a\u4e3a\u6d77\u9c9c\u5e02\u573a\u7684\u96f6\u552e\u5546\u8d29\u3002<\/span><\/section>\n

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\u60a3\u8005 2 \u521d\u59cb\u75c7\u72b6\u4ece 2019 \u5e74 12 \u6708 20 \u65e5\u5f00\u59cb\uff0c\u51fa\u73b0\u4e86\u53d1\u70ed\u548c\u54b3\u55fd\u3002\u5728\u8d77\u75c5\u540e 7 \u5929\u51fa\u73b0\u547c\u5438\u56f0\u96be\u4e14\u540e\u7eed 2 \u5929\u8fdb\u884c\u6027\u52a0\u91cd\uff08\u80f8\u7247\u8d44\u6599\u89c1\u56fe 1 \uff09\uff0c\u5728\u6b64\u671f\u95f4\u8fdb\u884c\u4e86\u673a\u68b0\u901a\u6c14\u3002\u8be5\u60a3\u8005\u66fe\u7ecf\u5e38\u51fa\u5165\u6d77\u9c9c\u5e02\u573a\u91c7\u8d2d\u3002<\/span><\/section>\n

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\"\u91cd\u8981\u6570\u636e<\/section>\n
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\u60a3\u8005 1 \u548c\u60a3\u8005 3 \u5728\u7ecf\u8fc7\u6cbb\u7597\u540e\u4e8e 2020 \u5e74 1 \u6708 16 \u65e5\u51fa\u9662\uff0c\u4f46\u60a3\u8005 2 \u5728 2020 \u5e74 1 \u6708 9 \u65e5\u6b7b\u4ea1\uff0c\u6ca1\u6709\u91c7\u96c6\u5230\u60a3\u8005\u7684\u7ec4\u7ec7\u6807\u672c\u3002<\/span> <\/section>\n

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2. \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u68c0\u6d4b\u548c\u5206\u79bb<\/span><\/strong><\/span><\/section>\n

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2019 \u5e74 12 \u6708 30 \u65e5\uff0c\u4ece\u6b66\u6c49\u91d1\u94f6\u6f6d\u533b\u9662\u91c7\u96c6\u4e86\u8fd9 3 \u4f4d\u60a3\u8005\u7684\u80ba\u6ce1\u704c\u6d17\u6db2\u3002\u7528 RespiFinderSmart22\u8bd5\u5242\u76d2\u5bf9\u8fd9\u4e9b\u4e34\u5e8a\u6807\u672c\u8fdb\u884c\u4e86\u5e38\u89c4\u68c0\u6d4b\uff0c\u4f46\u672a\u53d1\u73b0\u7279\u5f02\u6027\u75c5\u539f\u4f53\uff08\u5305\u62ec HCoV-229E\uff0c HCov-NL63, HCoV-OC43, and HCoV-HKU1\uff09\u3002<\/span><\/section>\n

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\u5bf9\u8fd9\u4e9b\u60a3\u8005\u7684\u80ba\u6ce1\u704c\u6d17\u6db2\u8fdb\u884c\u4e86 RNA \u63d0\u53d6\uff0c\u4f5c\u4e3a\u514b\u9686\u8f7d\u4f53\u6a21\u677f\uff1b\u91c7\u7528 Illumina \u548c Nanopore \u6d4b\u5e8f\u76f8\u7ed3\u5408\u65b9\u6cd5\u8fdb\u884c\u4e86\u57fa\u56e0\u6d4b\u5e8f\u3002\u4ece\u5355\u4e2a\u6807\u672c\u4e2d\u83b7\u5f97\u4e86\u8d85\u8fc7 20,000 \u4e2a\u75c5\u6bd2\u5e8f\u5217\u8bfb\u957f\uff0c\u5927\u591a\u6570\u5e8f\u5217\u7ed3\u679c\u663e\u793a\u4e0e\u4e59\u7fa4\u51a0\u72b6\u75c5\u6bd2\u5c5e\u7684 B \u8c31\u7cfb\u5339\u914d\uff0c\u6709\u8d85\u8fc7 85%\u57fa\u56e0\u5e8f\u5217\u4e0e\u6b64\u524d\u62a5\u9053\u7684\u8759\u8760\u4f53\u5185\u5206\u79bb\u5230 SARS-\u6837\u51a0\u72b6\u75c5\u6bd2 \uff08bat-SL-CoVZC45, MG772933.1\uff09\u6709\u9ad8\u5ea6\u4e00\u81f4\u6027\u3002<\/span><\/section>\n

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\u6211\u4eec\u5bf9\u4e00\u6bb5 RdRp \u533a\u57df\u7684\u6cdb\u4e59\u7fa4\u51a0\u72b6\u75c5\u6bd2\u7684 RNA \u8fdb\u884c\u4e86\u5b9e\u65f6\u9006\u8f6c\u5f55 PCR \u68c0\u6d4b\uff0c\u4e5f\u5f97\u5230\u4e86\u9633\u6027\u7684\u7ed3\u679c\uff08\u5c3d\u7ba1\u68c0\u6d4b\u5230\u6837\u672c\u5faa\u73af\u6570\u9608\u503c\u9ad8\u4e8e 34\uff09\u3002\u4e34\u5e8a\u75c5\u6bd2\u5206\u79bb\u91c7\u7528\u4eba\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u548c Vero E6 \u3001Huh-7 \u7ec6\u80de\u7cfb\uff0c\u5206\u79bb\u51fa\u7684\u75c5\u6bd2\u88ab\u547d\u540d\u4e3a 2019 \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u3002 <\/span>
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\u4e3a\u4e86\u660e\u786e 2019-nCoV \u611f\u67d3\u7684\u4eba\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u5185\u53ef\u5426\u89c2\u5bdf\u5230\u75c5\u6bd2\u9897\u7c92\uff0c\u6a21\u62df\u611f\u67d3\u548c 2019 \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u4eba\u7c7b\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u57f9\u517b\u7269\u6bcf\u5929\u7528\u5149\u5b66\u663e\u5fae\u955c\u8fdb\u884c\u89c2\u5bdf\uff0c\u57f9\u517b 6 \u5929\u540e\u7528\u900f\u5c04\u7535\u955c\u89c2\u5bdf\u3002<\/span><\/section>\n

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\u5728\u4eba\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u8868\u9762\u63a5\u79cd 96 \u5c0f\u65f6\u53ef\u4ee5\u89c2\u5bdf\u5230\u7ec6\u80de\u75c5\u53d8\u3002\u901a\u8fc7\u663e\u5fae\u955c\u89c2\u5bdf\uff0c\u53ef\u4ee5\u770b\u5230\u5728\u89c6\u91ce\u4e2d\u592e\uff08\u89c1\u56fe 2\uff09\uff0c\u7ec6\u80de\u7f3a\u4e4f\u7ea4\u6bdb\u8fd0\u52a8\u3002\u4f46\u5728 Vero E6 \u548c Huh-7 \u7ec6\u80de\u7cfb\u57f9\u517b 6 \u5929\u540e\u65e0\u7279\u5f02\u6027\u7ec6\u80de\u75c5\u53d8\u3002<\/span><\/section>\n

<\/section>\n
\"\u91cd\u8981\u6570\u636e<\/section>\n
\u56fe2  \u4eba\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u63a5\u79cd 2019-nCoV \u540e\u7684\u7ec6\u80de\u57f9\u517b\u56fe\u7247<\/span><\/section>\n

<\/section>\n
\u8d1f\u67d3\u6cd5\u7535\u955c\u4e0b\u89c2\u5bdf 2019 \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u4e00\u822c\u5448\u7403\u5f62\uff0c\u4f46\u6709\u4e9b\u5448\u591a\u5f62\u6027\uff08\u89c1\u56fe3\uff09\u3002\u76f4\u5f84\u5728 60\uff5e140nm \u4e4b\u95f4\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u75c5\u6bd2\u9897\u7c92\u6709\u660e\u663e\u7684\u68d8\u7a81\uff0c\u5927\u7ea6 9\uff5e12nm\uff0c\u5bfc\u81f4\u75c5\u6bd2\u5448\u73b0\u4e86\u65e5\u5195\u72b6\u3002\u5728\u4eba\u6c14\u9053\u4e0a\u76ae\u8d85\u8584\u5207\u7247\u4e2d\u53d1\u73b0\u4e86\u80de\u5916\u6e38\u79bb\u75c5\u6bd2\u9897\u7c92\u548c\u80de\u8d28\u819c\u56ca\u5185\u5145\u6ee1\u75c5\u6bd2\u9897\u7c92\u7684\u5305\u6db5\u4f53\u3002\u89c2\u5bdf\u5230\u7684\u8fd9\u4e00\u5f62\u6001\u4e0e\u51a0\u72b6\u75c5\u6bd2\u79d1\u4e00\u81f4\u3002<\/span><\/section>\n

<\/section>\n
\"\u91cd\u8981\u6570\u636e<\/section>\n
\u56fe 3  2019-nCoV \u5728\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u4e0b\u56fe\u7247<\/span><\/section>\n

<\/section>\n
\u4e3a\u4e86\u8fdb\u4e00\u6b65\u786e\u5b9a\u75c5\u6bd2\u7279\u5f81\uff0c\u5bf9\u60a3\u8005\u4e34\u5e8a\u6807\u672c\uff08\u80ba\u6ce1\u704c\u6d17\u6db2\uff09\u548c\u4eba\u7c7b\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u5206\u79bb\u5230\u7684\u75c5\u6bd2\u7528 Illumina \u548c Nanopore \u8fdb\u884c\u4e86\u6d4b\u5e8f\u5206\u6790\u3002\u4ece\u8fd9 3 \u4f4d\u60a3\u8005\u4f53\u5185\u90fd\u5206\u79bb\u5230\u4e86\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u3002<\/span><\/section>\n

<\/section>\n
\u4ece\u80ba\u6ce1\u704c\u6d17\u6db2\u4e2d\u83b7\u5f97\u4e86 2 \u4e2a\u5168\u957f\u7684\u51a0\u72b6\u75c5\u6bd2\u5e8f\u5217<\/span>(BetaCoV\/Wuhan\/IVDC- HB-04\/2020, BetaCoV\/Wuhan\/IVDC-HB-05\/2020|EPI_ISL_402121)<\/span>\uff0c\u548c\u4e00\u4f4d\u60a3\u8005\u4f53\u5185\u5206\u79bb\u5230\u7684\u75c5\u6bd2\u5168\u957f\u57fa\u56e0\u5e8f\u5217<\/span>(BetaCoV\/Wuhan\/IVDC-HB-01\/2020|EPI_ISL_402119)<\/span>\u3002<\/span>\u8fd9 3 \u4e2a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u5df2\u7ecf\u4e0a\u62a5\u7ed9GASAID\u7ec4\u7ec7\u3002<\/span>(BetaCoV\/Wuhan\/IVDC-HB-01\/2019, accession ID: EPI_ISL_402119; BetaCoV\/Wuhan\/IVDC-HB-04\/2020, accession ID: EPI_ISL_402120; BetaCoV\/Wuhan\/IVDC-HB-05\/2019, accession ID: EPI_ISL_402121\uff09<\/span>\u4e14 86.9% \u6838\u9178\u5e8f\u5217\u4e0e\u4e4b\u524d\u62a5\u9053\u8fc7\u7684\u8759\u8760\u4f53\u5185\u5206\u79bb\u5230\u7684 SARS \u6837\u51a0\u72b6\u75c5\u6bd2<\/span>(bat-SL-CoVZC45, MG772933.1)<\/span>\u6709\u9ad8\u5ea6\u4e00\u81f4\u6027\u3002<\/span><\/span><\/section>\n

<\/section>\n
\u8fd9 3 \u4e2a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u57fa\u56e0\u6c47\u603b\u5f62\u6210\u4e86 Sarbe \u51a0\u72b6\u75c5\u6bd2\u4e9a\u5c5e\u4e2d\u7684\u72ec\u7acb\u5206\u679d\uff0c\u663e\u793a\u4e86\u5178\u578b\u7684\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u5c5e\u7ed3\u6784\uff1a\u4e00\u4e2a5\u2032\u975e\u7ffb\u8bd1\u533a\uff08UTR\uff09\u3001\u590d\u5236\u9176\u590d\u5408\u7269\uff08orf1ab\uff09\u3001S \u57fa\u56e0\u3001E \u57fa\u56e0\u3001M \u57fa\u56e0\u3001N \u57fa\u56e0\u30013\u2032UTR \u548c\u51e0\u4e2a\u672a\u8bc6\u522b\u7684\u975e\u7ed3\u6784\u5f00\u653e\u8bfb\u7801\u6846\u3002<\/span><\/section>\n

<\/section>\n
\u5c3d\u7ba1 2019-nCov \u4e0e\u8759\u8760\u4f53\u5185\u5206\u79bb\u5230\u7684\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u76f8\u4f3c\uff08\u56fe 4\uff09\uff0c\u4f46\u662f\u4e0e SARS \u51a0\u72b6\u75c5\u6bd2\u548c MERS \u51a0\u72b6\u75c5\u6bd2\u6709\u660e\u663e\u4e0d\u540c\u3002<\/span><\/section>\n

<\/span><\/section>\n
\"\u91cd\u8981\u6570\u636e<\/section>\n
\u56fe 4  2019-nCoV \u548c\u6b63\u51a0\u72b6\u75c5\u6bd2\u4e9a\u79d1\u4e2d\u5176\u4ed6\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u57fa\u56e0\u7cfb\u7edf\u53d1\u80b2\u6811\u5206\u6790\u56fe<\/span><\/section>\n

<\/span><\/section>\n
\u8fd9 3 \u4efd\u6765\u81ea\u6b66\u6c49\u7684 2019 \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u4e0e 2 \u4efd\u6765\u81ea\u8759\u8760\u4f53\u5185\u7684 SARS \u6837\u75c5\u6bd2\u682a ZC45\uff0cZXC21 \u5f62\u6210\u4e86 Sarbe \u51a0\u72b6\u75c5\u6bd2\u4e9a\u5c5e B \u8c31\u7cfb\u4e2d\u4e00\u4e2a\u65b0\u7684\u5206\u679d\uff1b\u6765\u81ea\u4eba\u4f53\u7684 SARS \u51a0\u72b6\u75c5\u6bd2\u5219\u4e0e\u4e2d\u56fd\u897f\u5357\u90e8\u8759\u8760\u4f53\u5185\u5206\u79bb\u5230 SARS \u6837\u51a0\u72b6\u75c5\u6bd2\u5171\u540c\u5f62\u6210\u4e86 Sarbe \u51a0\u72b6\u75c5\u6bd2\u4e9a\u5c5e\u7684\u53e6\u5916\u4e00\u4e2a\u5206\u679d\u3002<\/span><\/section>\n

<\/section>\n
2019-nCoV \u548c \uf062<\/span>-\u51a0\u72b6\u75c5\u6bd2\u5728\u4fdd\u5b88\u533a\u57df\u590d\u5236\u9176\uff08ORF 1ab\uff09\u5e8f\u5217\u4e00\u81f4\u6027\u65b9\u9762\u6ca1\u6709\u8fbe\u5230 90%\uff0c\u56e0\u6b64 2019 \u5e74\u6b66\u6c49\u75c5\u6bd2\u6027\u80ba\u708e\u7684\u53ef\u80fd\u75c5\u539f\u4f53 2019-nCov \u662f\u4e00\u79cd\u65b0\u578b\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\uff0c\u5c5e\u4e8e\u51a0\u72b6\u75c5\u6bd2\u79d1\u4e2d\u7684 Sarbe \u51a0\u72b6\u75c5\u6bd2\u4e9a\u5c5e\u3002 <\/span><\/section>\n

<\/section>\n

<\/section>\n
\u8ba8\u8bba<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n
\u6211\u4eec\u62a5\u9053\u4e86 2019 \u5e74 12 \u6708\u548c 2020 \u5e74 1 \u6708\u5728\u4e2d\u56fd\u6b66\u6c49\u4f4f\u9662\u60a3\u8005\u4e2d\u53d1\u73b0\u7684\u4e00\u79cd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff082019-nCoV\uff09\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u8be5\u75c5\u6bd2\u5b58\u5728\u7684\u8bc1\u636e\u5305\u62ec\u5728\u4e09\u540d\u60a3\u8005\u7684\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6db2\u4e2d\u7528\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u3001\u76f4\u63a5PCR \u548c\u57f9\u517b\u65b9\u6cd5\u5747\u9274\u5b9a\u51fa\u6b64\u75c5\u6bd2\u3002\u8fd9\u79cd\u53ef\u80fd\u7531\u51a0\u72b6\u75c5\u6bd2\u5f15\u8d77\u7684\u75be\u75c5\u88ab\u547d\u540d\u4e3a\u300c\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u80ba\u708e\u300d\uff08NCIP\uff09\uff0c\u5b8c\u6574\u7684\u57fa\u56e0\u7ec4\u5df2\u63d0\u4ea4\u7ed9 GASAID \u7f51\u7ad9\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u7cfb\u7edf\u53d1\u80b2\u6811\u5206\u6790\u663e\u793a\uff0c2019-nCoV \u5c5e\u4e8e\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u5c5e\uff1b\u4e59\u578b\u51a0\u72b6\u75c5\u6bd2\u5c5e\u5305\u62ec\u4e86\u5728\u4eba\u3001\u8759\u8760\u548c\u5176\u4ed6\u91ce\u751f\u52a8\u7269\u4e2d\u53d1\u73b0\u7684\u51a0\u72b6\u75c5\u6bd2\uff08 SARS \u51a0\u72b6\u75c5\u6bd2\u3001\u8759\u8760\u7c7b SARS \u51a0\u72b6\u75c5\u6bd2\u7b49\uff09\u3002\u6211\u4eec\u62a5\u9053\u4e86\u6b64\u75c5\u6bd2\u7684\u5206\u79bb\u53ca\u7279\u5f02\u6027\u7ec6\u80de\u75c5\u53d8\u4f5c\u7528\u548c\u5f62\u6001\u5b66\u7684\u521d\u6b65\u63cf\u8ff0\u3002<\/span>
<\/section>\n

<\/section>\n
\u591a\u5e74\u6765\uff0c\u5206\u5b50\u6280\u672f\u5df2\u88ab\u6210\u529f\u8fd0\u7528\u4e8e\u9274\u5b9a\u611f\u67d3\u6e90\uff0c\u5168\u57fa\u56e0\u7ec4\u9ad8\u901a\u91cf\u6d4b\u5e8f\u662f\u53d1\u73b0\u75c5\u539f\u4f53\u7684\u6709\u529b\u5de5\u5177\u3002\u4e8c\u4ee3\u6d4b\u5e8f\u548c\u751f\u7269\u4fe1\u606f\u5b66\u6b63\u5728\u6539\u53d8\u6211\u4eec\u5e94\u5bf9\u4f20\u67d3\u75c5\u66b4\u53d1\u7684\u65b9\u5f0f\uff0c\u63d0\u9ad8\u4e86\u6211\u4eec\u5bf9\u75be\u75c5\u53d1\u751f\u548c\u4f20\u64ad\u7684\u7406\u89e3\u3001\u52a0\u901f\u75c5\u539f\u4f53\u7684\u9274\u522b\u548c\u4fc3\u8fdb\u6570\u636e\u7684\u5171\u4eab\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6211\u4eec\u5728\u8fd9\u7bc7\u62a5\u9053\u4e2d\u63cf\u8ff0\u4e86\u5229\u7528\u5206\u5b50\u6280\u672f\u548c\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u53d1\u73b0\u7684\u4e00\u79cd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff0c\u5b83\u53ef\u80fd\u662f\u5bfc\u81f4\u4e2d\u56fd\u6b66\u6c49 3 \u4f8b\u91cd\u75c7\u80ba\u708e\u7684\u5143\u51f6\u3002<\/span><\/section>\n

<\/section>\n
\u867d\u7136\u5efa\u7acb\u4eba\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u57f9\u517b\u65b9\u6cd5\u662f\u8d39\u65f6\u8d39\u529b\u7684\u5de5\u4f5c\uff0c\u4f46\u5b83\u662f\u5206\u6790\u4eba\u547c\u5438\u9053\u75c5\u539f\u4f53\u7684\u91cd\u8981\u7814\u7a76\u5de5\u5177\u3002\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u5148\u5728\u4eba\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u57f9\u517b\u7269\u4e0a\u589e\u6b96\u547c\u5438\u9053\u5206\u6ccc\u7269\uff0c\u518d\u7528\u900f\u5c04\u7535\u955c\u548c\u5168\u57fa\u56e0\u6d4b\u5e8f\u5206\u6790\u57f9\u517b\u4e0a\u6e05\u7269\uff0c\u6210\u529f\u5730\u89c2\u5bdf\u548c\u68c0\u6d4b\u5230\u4e86\u65b0\u7684\u4eba\u51a0\u72b6\u75c5\u6bd2\uff0c\u8fd9\u53ef\u80fd\u662f\u4f20\u7edf\u65b9\u6cd5\u65e0\u6cd5\u505a\u5230\u7684\u3002<\/span><\/section>\n

<\/section>\n
\u6211\u4eec\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u5efa\u7acb\u53ef\u51c6\u786e\u3001\u5feb\u901f\u9274\u522b\u547c\u5438\u9053\u672a\u77e5\u75c5\u539f\u4f53\u7684\u65b9\u6cd5\u3002\u57fa\u4e8e\u5728\u6b64\u7814\u7a76\u4e2d\u5f97\u5230\u7684 3 \u6761\u5b8c\u6574\u57fa\u56e0\u7ec4\uff0c\u6211\u4eec\u8bbe\u8ba1\u4e86\u51e0\u4e2a\u9488\u5bf9 2019-nCoV \u57fa\u56e0\u7ec4\u7684 ORF1ab\u3001N \u548c E \u533a\u57df\u7684\u7279\u5f02\u548c\u654f\u611f\u7684\u68c0\u6d4b\uff0c\u53ef\u4ee5\u68c0\u6d4b\u51fa\u4e34\u5e8a\u6837\u672c\u4e2d\u7684\u75c5\u6bd2 RNA \u3002\u5f15\u7269\u96c6\u548c\u6807\u51c6\u64cd\u4f5c\u7a0b\u5e8f\u5df2\u4e0e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5171\u4eab\uff0c\u7528\u4e8e\u5728\u5168\u7403\u548c\u4e2d\u56fd\u76d1\u6d4b\u548c\u68c0\u6d4b2019-nCoV \u611f\u67d3\u3002\u6700\u65b0\u7684\u6570\u636e\u663e\u793a\uff0c\u4e2d\u56fd\u5df2\u6709 830 \u4eba \u68c0\u6d4b\u51fa 2019-nCoV\u3002<\/span><\/section>\n

<\/section>\n
\u867d\u7136\u6211\u4eec\u7684\u7814\u7a76\u6ca1\u6709\u5b8c\u5168\u9075\u5faa\u79d1\u8d6b\u6cd5\u5219\uff0c\u4f46\u6211\u4eec\u7684\u5206\u6790\u63d0\u4f9b\u4e86\u6b66\u6c49\u7206\u53d1 2019-nCoV \u7684\u8bc1\u636e\u3002\u6211\u4eec\u8fd8\u9700\u63d0\u4f9b\u6709\u5173 2019-nCoV \u5f15\u8d77\u6b66\u6c49\u75ab\u60c5\u7684\u5176\u4ed6\u8bc1\u636e\uff0c\u5305\u62ec\u5728\u60a3\u8005\u7684\u80ba\u7ec4\u7ec7\u4e2d\u7528\u514d\u75ab\u7ec4\u5316\u65b9\u6cd5\u68c0\u6d4b\u5230 2019-nCoV \u6297\u539f\uff0c\u4ece\u540c\u4e00\u60a3\u8005\u4e24\u4e2a\u65f6\u95f4\u70b9\u7684\u8840\u6e05\u6807\u672c\u4e2d\u68c0\u6d4b\u51fa\u53ef\u8bc1\u5b9e\u8840\u6e05\u8f6c\u5316\u7684\u6297\u75c5\u6bd2 IgM \u548c IgG \u6297\u4f53\uff0c\u4ee5\u53ca\u6765\u81ea\u52a8\u7269\uff08\u7334\u5b50\uff09\u5b9e\u9a8c\u7684\u81f4\u75c5\u6027\u8bc1\u636e\u3002<\/span><\/section>\n

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\u5317\u4eac\u65f6\u95f4\u519c\u5386\u9f20\u5e74\u6625\u8282\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u53d1\u8868\u7814\u7a76\u8bba\u6587 A Novel Coronavirus from Pa […]<\/p>\n","protected":false},"author":1,"featured_media":132314,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/132313"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=132313"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/132313\/revisions"}],"predecessor-version":[{"id":132324,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/132313\/revisions\/132324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/132314"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=132313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=132313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=132313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}