{"id":133229,"date":"2020-02-11T04:35:43","date_gmt":"2020-04-21T03:20:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/133229\/"},"modified":"2020-04-21T11:20:16","modified_gmt":"2020-04-21T03:20:16","slug":"2ec2493910","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/133229\/","title":{"rendered":"\u65b0\u51a0\u80ba\u708e\u60a3\u8005 ACEI\/ARB \u505c\u4e0d\u505c\uff1f\u4e13\u5bb6\u4e89\u8bba\u4e0d\u4e00"},"content":{"rendered":"
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\u8fd1\u671f\uff0c\u9488\u5bf9\u5408\u5e76\u9ad8\u8840\u538b\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u662f\u5426\u5e94\u505c\u7528 ACEI\/ARB \u7c7b\u836f\u7269\uff0c\u5f15\u8d77\u4e86\u5927\u5bb6\u5e7f\u6cdb\u5173\u6ce8\uff0c\u4e3b\u8981\u5206\u4e3a\u4e24\u5927\u9635\u8425\u3002<\/span>
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\u6709\u4eba\u8ba4\u4e3a\uff0cACEI\/ARB \u7c7b\u836f\u7269\u53ef\u4ee5\u63d0\u9ad8\u80ba\u90e8 ACE2 \u7684\u6c34\u5e73\uff0c\u4ece\u800c\u4e3a\u75c5\u6bd2\u5927\u5f00\u300c\u65b9\u4fbf\u4e4b\u95e8\u300d\uff1b\u53e6\u5916\u4e00\u65b9\u89c2\u70b9\u5219\u8ba4\u4e3a\u8fd9\u7c7b\u836f\u7269\u53ef\u51cf\u8f7b\u80ba\u90e8\u548c\u5fc3\u8840\u7ba1\u635f\u4f24\u3002<\/span><\/section>\n

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\u4e3a\u4f55\u4e24\u65b9\u7684\u89c2\u70b9\u4f1a\u622a\u7136\u76f8\u53cd\u5462\uff1f\u4e3a\u4e86\u5f04\u6e05\u8fd9\u4e2a\u95ee\u9898\uff0c\u7b14\u8005\u7279\u68b3\u7406\u300c\u6b63\u53cd\u65b9\u300d\u89c2\u70b9\u5982\u4e0b\uff0c\u4f9b\u5927\u5bb6\u53c2\u8003\u3002<\/span><\/section>\n

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<\/section>\n
\u89c2\u70b9\u4e00\uff1a<\/strong><\/span><\/section>\n
\u5408\u5e76\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u9ad8\u8840\u538b\u60a3\u8005\uff0c\u5e94\u505c\u7528 ACEI\/ARB \u7c7b\u964d\u538b\u836f\u7269<\/strong><\/span><\/section>\n

<\/section>\n

1. \u6301\u76f8\u53cd\u89c2\u70b9\u7684\u540c\u4ec1\u8ba4\u4e3a\u75c5\u6bd2\u7ed3\u5408\u540e ACE-2 \u4e0b\u8c03\uff0c\u6fc0\u6d3b RAAS \u7cfb\u7edf\uff0c\u8fc7\u5ea6\u523a\u6fc0 AT1 \u53d7\u4f53\uff0c\u5bfc\u81f4\u80ba\u8840\u7ba1\u901a\u900f\u6027\u589e\u52a0\uff0c\u4ece\u800c\u5f15\u8d77\u80ba\u635f\u4f24\u52a0\u91cd\uff0c\u6b64\u673a\u5236\u6765\u6e90\u4e8e SARS-Cov \u75c5\u6bd2\u80ba\u708e\u7684\u7814\u7a76\uff0c\u800c\u4e0d\u662f\u65b0\u51a0\u75c5\u6bd2\u80ba\u708e\uff0c<\/strong>\u4e24\u8005\u662f\u5426\u6709\u540c\u6837\u4f5c\u7528\u673a\u5236\uff0c\u76ee\u524d\u6ca1\u6709\u6570\u636e\u8bc1\u5b9e\uff0c\u4ece\u5f71\u50cf\u5b66\u548c\u4e34\u5e8a\u6765\u770b\uff0c\u80ba\u635f\u4f24\u66f4\u652f\u6301\u662f\u5c40\u90e8\u75c5\u6bd2\u611f\u67d3\u514d\u75ab\u53cd\u5e94\u6240\u81f4\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u5916\uff0c\u5982\u679c\u771f\u662f\u53cd\u5c04 RAAS \u6fc0\u6d3b\u5bfc\u81f4\u80ba\u635f\u4f24\uff0c\u5e94\u7528 ACEI\/ARB \u5e94\u8be5\u635f\u4f24\u660e\u663e\u51cf\u8f7b\uff0c\u76ee\u524d\u6765\u770b\u5bf9\u4e8e\u65b0\u51a0\u80ba\u708e\u4ecd\u7136\u6ca1\u6709\u7279\u6548\u836f\uff0c\u4e14\u524d\u671f\u5e94\u7528\u6b64\u7c7b\u836f\u7269\u7684\u80ba\u708e\u60a3\u8005\u4e5f\u6ca1\u6709\u8bc1\u636e\u663e\u793a\u53ef\u963b\u6b62\u75c5\u60c5\u8fdb\u5c55\u3002<\/span><\/p>\n


<\/p>\n

2. Ferrario \u7b49\u53d1\u8868\u5728 Circulation \u4e0a\u7684\u7814\u7a76\u663e\u793a\uff0c\u7ed9\u5927\u9f20\u5e94\u7528 ACEI\/AT \u53d7\u4f53\u62ee\u6297\u5242<\/span>\u540e\u8840\u538b\u4e0b\u964d\u7684\u540c\u65f6\uff0cACE-2 \u6c34\u5e73\u5206\u522b\u589e\u9ad8\u4e86 4.7 \u548c 2.8 \u500d [1]\uff0c\u6240\u4ee5\u5e94\u7528 ACEI\/ARB \u6709\u5347\u9ad8 ACE-2 \u7684\u98ce\u9669\uff0c\u4ece\u800c\u5bfc\u81f4\u75c5\u6bd2\u66f4\u5bb9\u6613\u5165\u4fb5\u7ec6\u80de\u3002<\/span><\/span><\/p>\n


<\/p>\n

3. 2018 \u5e74\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\uff0c\u56de\u987e\u6027\u5206\u6790\u4e86 539 \u4f8b\u75c5\u6bd2\u6027\u80ba\u708e\u60a3\u8005\uff0c\u7ed3\u679c\u53d1\u73b0\u5165\u9662\u524d\u7ed9\u4e88 ACEI \u548c\u4ed6\u6c40\u7c7b\u836f\u7269\uff0c\u4e0d\u80fd\u964d\u4f4e\u75c5\u6bd2\u6027\u80ba\u708e\uff08\u975e\u65b0\u51a0\u80ba\u708e\uff09\u60a3\u8005\u7684\u6b7b\u4ea1\u7387\u53ca\u63d2\u7ba1\u7387\u3002\u5f88\u53ef\u80fd\u7ed3\u679c\u4e5f\u4f1a\u51fa\u73b0\u5728\u65b0\u51a0\u80ba\u708e\u4e2d\u3002<\/span><\/p>\n


<\/p>\n

4. \u4e00\u7ebf\u964d\u538b\u836f\u5171\u6709 5 \u79cd\uff0c<\/span>\u5728\u6ca1\u6709\u8bc1\u636e\u8bc1\u660e\u65b0\u51a0\u80ba\u708e\u7684\u60a3\u8005\u5e94\u7528 ACEI\/ARB \u6709\u76ca\uff0c\u800c\u53ef\u80fd\u6709\u5bb3\u7684\u524d\u63d0\u4e0b\uff0c\u5408\u5e76\u65b0\u51a0\u80ba\u708e\u7684\u9ad8\u8840\u538b\u60a3\u8005\u6ca1\u5fc5\u8981\u4e00\u5b9a\u5e94\u7528 ACEI\/ARB\uff0c\u81f3\u5c11\u4e0d\u5e94\u5728\u75c5\u6bd2\u611f\u67d3\u5230\u6062\u590d\u7684\u77ed\u65f6\u95f4\u5185\u5e94\u7528\u3002<\/span><\/span><\/p>\n


<\/span><\/strong><\/section>\n

<\/span><\/strong><\/section>\n
\u89c2\u70b9\u4e8c\uff1a<\/span><\/strong>
<\/section>\n
\u5408\u5e76\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u9ad8\u8840\u538b\u60a3\u8005\uff0c\u65e0\u9700\u505c\u7528 ACEI\/ARB \u7c7b\u964d\u538b\u836f\u7269<\/span><\/strong><\/section>\n

<\/section>\n

1. \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u548c SARS \u75c5\u6bd2\u7c7b\u4f3c\uff0c\u5176\u5dee\u5f02\u4e3b\u8981\u5728\u56db\u4e2a\u86cb\u767d\u8d28\u4e0a\uff0c\u800c Spike \u86cb\u767d\u548c SARS \u75c5\u6bd2\u7684 Spike \u86cb\u767d\u9ad8\u5ea6\u76f8\u4f3c\uff0c\u4e8c\u8005\u7684\u5dee\u5f02\u4ec5\u6709 4 \u4e2a\u6c28\u57fa\u9178\u3002Spike \u86cb\u767d\u53ef\u5e2e\u52a9\u75c5\u6bd2\u548c\u5bbf\u4e3b\u7ec6\u80de\u819c\u4e0a\u7684\u8de8\u819c\u53d7\u4f53\u86cb\u767d\u8d28\u7ed3\u5408\uff0c\u4ece\u800c\u5e2e\u52a9\u81ea\u5df1\u8fdb\u5165\u5bbf\u4e3b\u7684\u7ec6\u80de\u5185\u90e8\u3002<\/span><\/p>\n


<\/p>\n

\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u663e\u793a\uff0c\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684 Spike \u86cb\u767d\u4e0a\u7684\u6c28\u57fa\u9178\u53d8\u5316\u4f3c\u4e4e\u6ca1\u6709\u5f71\u54cd S-\u86cb\u767d\u4e0e\u53d7\u4f53 ACE-2 \u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u56e0\u6b64\uff0c\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u5c31\u662f\u901a\u8fc7 Spike \u86cb\u767d\u4e0e ACE-2 \u86cb\u767d\u7684\u7ed3\u5408\u4ecb\u5bfc\u8fdb\u5165\u7ec6\u80de\u5185\u90e8\u3002\u6240\u4ee5\uff0c\u57fa\u672c\u53ef\u4ee5\u8ba4\u4e3a\u4e24\u4e2a\u75c5\u6bd2\u7684 Spike \u86cb\u767d\u5f15\u53d1\u7684\u6548\u679c\u662f\u76f8\u4f3c\u7684\uff0c\u5373\u901a\u8fc7\u964d\u4f4e ACE-2\uff0c\u6fc0\u6d3b RAAS \u7cfb\u7edf\uff0c\u5bfc\u81f4\u80ba\u635f\u4f24<\/span><\/span>\u3002<\/span><\/p>\n


<\/p>\n

2. Ferrario \u7b49\u7684\u7814\u7a76\u662f\u9488\u5bf9\u6b63\u5e38\u8840\u538b\u7684 Lewis \u5927\u9f20\uff0c\u7ed3\u8bba\u4e0d\u80fd\u63a8\u5e7f\u5230\u9ad8\u8840\u538b\u5927\u9f20\u4e0a\uff0c\u66f4\u4e0d\u80fd\u63a8\u5e7f\u5230\u9ad8\u8840\u538b\u4eba\u7fa4\u4e0a\u3002<\/span><\/span>\u5b9e\u9645\u4e0a\u9ad8\u8840\u538b\u5927\u9f20\u7684 ACE-2 mRNA \u6c34\u5e73\u662f\u663e\u8457\u964d\u4f4e\u7684 [2]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9ad8\u8840\u538b\u60a3\u8005\u672c\u8eab\u5c31\u4f1a\u6709 ACE-2 \u86cb\u767d\u7684\u8868\u8fbe\u91cf\u964d\u4f4e\uff0c\u5982\u679c\u53d7\u5230\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u611f\u67d3\u5c31\u53ef\u80fd\u4f1a\u5f15\u53d1\u66f4\u4e25\u91cd\u7684\u80ba\u8870\u7aed\u300240% \u4ee5\u4e0a\u7684\u91cd\u75c7\u60a3\u8005\u548c\u75c5\u6545\u60a3\u8005\uff0c\u90fd\u6709\u9ad8\u8840\u538b\u75c5\u53f2\uff0c\u8fd9\u4e5f\u8bc1\u5b9e\u4e86\u75c5\u6bd2\u4e0e ACE-2 \u7684\u5173\u7cfb\u3002<\/span><\/p>\n


<\/section>\n

\u4f46\u662f\u4ed6\u4eec\u7684\u6b7b\u4ea1\u7387\u9ad8\u4e0d\u80fd\u5f52\u56e0\u4e8e\u4f7f\u7528 RAAS \u963b\u65ad\u5242\u3002\u6700\u5927\u7684\u539f\u56e0\u662f\u8fd9\u4e9b\u60a3\u8005\u57fa\u7840\u72b6\u6001\u672c\u8eab\u5c31\u5f88\u5dee\uff1a\u9ad8\u9f84\u4e14\u5f80\u5f80\u5408\u5e76\u591a\u79cd\u6162\u6027\u75c5\u3002<\/span><\/p>\n


<\/p>\n

3. \u76ee\u524d\u6211\u4eec\u6ca1\u529e\u6cd5\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u884c\u9a8c\u8bc1\uff0c\u4f46\u4e4b\u524d\u7684\u4e00\u4e9b\u52a8\u7269\u5b9e\u9a8c\u53ef\u80fd\u4f1a\u63d0\u4f9b\u4e00\u4e9b\u53c2\u8003\u3002<\/span><\/p>\n


<\/section>\n

\u6709\u7814\u7a76\u8005\u4f7f\u7528 SARS \u75c5\u6bd2 Spike \u86cb\u767d\u7684\u4e00\u4e2a\u7247\u6bb5 Spike-Fc \u6765\u6a21\u62df\u75c5\u6bd2\u5bf9 ACE-2 \u86cb\u767d\u7684\u4e0b\u8c03\u4f5c\u7528\u3002\u5b9e\u9a8c\u7ed3\u679c\u63d0\u793a Spike-Fc \u53ef\u4ee5\u52a0\u91cd\u9178\u9020\u6210\u7684\u6025\u6027\u80ba\u635f\u4f24\u3002<\/span><\/p>\n


<\/p>\n

\u800c\u5728\u7ed9\u4e88 AT1 \u6291\u5236\u5242\u540e\uff0c\u53cd\u800c\u53ef\u4ee5\u7f13\u89e3 Spike-Fc \u52a0\u91cd\u7684\u8fd9\u4e00\u90e8\u5206\u635f\u4f24\uff0c\u5373\u4fbf\u5728\u9178\u4e2d\u6bd2\u73af\u5883\u4e0b\uff0c\u8fd9\u4e00\u7ed3\u8bba\u4ecd\u7136\u6210\u7acb\u3002<\/span>
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<\/p>\n

\u4ece\u6587\u732e\u770b\uff0c\u4f7f\u7528 ARB \u7c7b\u836f\u7269\u540e\u5bfc\u81f4\u80ba\u90e8 ACE-2 \u53cd\u9988\u6027\u5347\u9ad8\uff0c\u5176\u6539\u5584\u80ba\u90e8\u708e\u75c7\u7684\u4f5c\u7528\u62b5\u6d88\u5176\u4ecb\u5bfc\u75c5\u6bd2\u611f\u67d3\u7684\u4f5c\u7528\uff0c\u53ef\u80fd\u662f\u5229\u5927\u4e8e\u5f0a\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u6ce8\uff1a\u672c\u6587\u5185\u5bb9\u4e3a\u5b66\u672f\u63a2\u8ba8\uff0c\u4ec5\u4f9b\u533b\u7597\u4e13\u4e1a\u4eba\u58eb\u9605\u8bfb\u3002<\/strong><\/span><\/section>\n


<\/span><\/p>\n

\n
\n
\n

\u8fd9\u4e2a\u95ee\u9898\u60a8\u600e\u4e48\u770b\uff1f\u5982\u679c\u60a8\u4e5f\u662f\u5fc3\u8840\u7ba1\u5185\u79d1\u4e13\u79d1\u533b\u751f\uff0c\u6b22\u8fce\u5728\u8bc4\u8bba\u533a\u53c2\u4e0e\u8ba8\u8bba\u53d1\u8868\u89c1\u89e3\u3002<\/span><\/p>\n<\/section>\n


<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n
\u6765\u6e90\uff1a\u516c\u4f17\u53f7\u300c\u5468\u5927\u4eae\u533b\u751f\u300d\u3001\u300c\u5b54\u8f83\u7626\u300d\uff0c\u7ecf\u6388\u6743\u4fee\u6539\u53d1\u5e03\uff0c\u672c\u6587\u9996\u53d1\u4e8e\u5fc3\u8840\u7ba1\u65f6\u95f4\uff0c<\/span>\u7f16\u8f91\uff1a\u4e3d\u96c5\uff0c\u9898\u56fe\u6765\u6e90\uff1a\u56fe\u866b\u521b\u610f<\/span><\/section>\n

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\"\u65b0\u51a0\u80ba\u708e\u60a3\u8005<\/section>\n

<\/section>\n
\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/span><\/strong><\/span><\/section>\n
[1] Ferrario CM, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005, 111(20):2605-10.<\/span><\/section>\n
[2] Crackower MA, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002, 417(6891):822-8.<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n

\u2193\u2193\u2193 \u70b9\u51fb\u9605\u8bfb\u539f\u6587\u67e5\u770b\u65b0\u51a0\u80ba\u708e\u5b66\u672f\u8fdb\u5c55\u5408\u96c6<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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