{"id":133402,"date":"2020-02-13T04:49:07","date_gmt":"2020-04-21T03:22:09","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/133402\/"},"modified":"2020-04-21T11:22:15","modified_gmt":"2020-04-21T03:22:15","slug":"f111382759","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/133402\/","title":{"rendered":"\u6b66\u6c49\u65b9\u8231\u9996\u6279\u60a3\u8005\u51fa\u9662\uff1a\u5efa\u7acb\u65b9\u8231\u80cc\u540e\u7684\u903b\u8f91\u662f\u4ec0\u4e48\uff1f"},"content":{"rendered":"
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\u5bf9\u4e8e\u7591\u4f3c\u60a3\u8005\u548c\u53d1\u70ed\u60a3\u8005\uff0c<\/span><\/span>\u901a\u8fc7\u5f81\u7528\u9152\u5e97\u3001\u62db\u5f85\u6240\u3001\u95f2\u7f6e\u5382\u623f\u7b49\u8fdb\u884c\u96c6\u4e2d\u9694\u79bb\uff08\u5355\u4eba\u5355\u95f4\uff09\uff0c\u5b9e\u884c\u5148\u9694\u79bb\u518d\u68c0\u6d4b\u3001\u518d\u8bca\u7597\uff1b\u5bf9\u4e8e<\/span>\u8f7b\u75c7\u786e\u8bca\u60a3<\/span>\u8005\uff0c\u6536\u5165<\/span>\u65b9\u8231\u9694\u79bb\uff1b\u5bf9\u4e8e\u91cd\u75c7\u60a3\u8005\uff0c\u6536\u5165\u533b\u9662\u6cbb\u7597\u3002<\/span><\/span><\/section>\n

<\/section>\n
\u8fd9\u6837\u4e00\u6765<\/span>\uff0c<\/span>\u65b9\u8231\u533b\u9662\u5c06\u8f7b\u75c7\u60a3\u8005\u4e0e\u5916\u754c\u4e25\u683c\u9694\u79bb\u540e\uff0c<\/span>\u6709\u52a9\u4e8e\u964d\u4f4e\u5065\u5eb7\u4eba\u7fa4\u611f\u67d3\u98ce\u9669\uff0c\u589e\u52a0\u533b\u52a1\u4eba\u5458\u7684\u96c6\u4e2d\u8bca\u7597\u6548\u7387\uff0c<\/span>\u5bf9\u60a3\u8005\u81ea\u8eab\u800c\u8a00\uff0c\u4e5f\u80fd\u51cf\u5c11\u6765\u56de\u5954\u6ce2\u3001\u9632\u6b62\u4f20\u67d3\u7ed9\u81ea\u5df1\u7684\u5bb6\u4eba\uff0c\u4ece\u800c<\/span>\u53d1\u6325\u51cf\u7f13\u65b0<\/span>\u589e\u75c5\u4f8b\uff0c\u5373<\/span>\u300c<\/span>\u7f13<\/span>\u589e<\/span>\u91cf\u300d\u7684\u4f5c\u7528\u3002<\/span><\/section>\n
<\/span><\/section>\n
<\/span><\/section>\n

<\/span><\/span><\/section>\n
<\/span>\u5f53\u65b9\u8231\u6709\u6548\u8fd0\u884c\u540e\uff0c\u53d1\u70ed\u5b9a\u70b9\u533b\u9662\u7684\u89d2\u8272\u4e5f\u5c06\u53d1\u751f\u53d8\u5316\uff0c<\/span>\u533b\u9662\u7684\u4efb\u52a1\u5c06\u7740\u91cd\u4e8e\u8bca\u65ad\u65b0\u51a0\u4e0e\u62ef\u6551\u5371\u75c7\uff0c\u627f\u62c5\u7ed9\u65b0\u51a0\u75c5\u4f8b\u300c\u51cf\u5b58\u91cf\u300d\u7684\u4f5c\u7528\u3002<\/span><\/section>\n

<\/span><\/section>\n
\"\u6b66\u6c49\u65b9\u8231\u9996\u6279\u60a3\u8005\u51fa\u9662\uff1a\u5efa\u7acb\u65b9\u8231\u80cc\u540e\u7684\u903b\u8f91\u662f\u4ec0\u4e48\uff1f\"<\/span><\/section>\n
<\/span> | \u4e01\u9999\u533b\u751f\u75ab\u60c5\u5730\u56fe<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u901a\u8fc7\u5efa\u7acb\u65b9\u8231\uff0c\u5c06\u91cd\u75c7\u4e0e\u8f7b\u75c7\u60a3\u8005\u7684\u8bca\u7597\u5206\u5f00\uff0c<\/span>\u65b9\u8231\u7f13\u589e\u91cf\uff0c\u533b\u9662\u51cf\u5b58\u91cf\uff0c<\/span>\u80fd\u591f\u66f4<\/span>\u52a0\u9ad8\u6548\u5730\u5229\u7528\u539f\u672c\u5c31\u6781\u4e3a\u7d27\u7f3a\u7684\u533b\u7597\u8d44\u6e90\u3002<\/span><\/span><\/section>\n

<\/section>\n

<\/section>\n
\u548c\u300c\u8fdb\u5316\u300d\u8d5b\u8dd1<\/span><\/strong><\/span><\/section>\n

<\/section>\n
\u4ece 2 \u6708 3 \u65e5\u5efa\u8bbe\u65b9\u8231\u533b\u9662\u7684\u547d\u4ee4\u53d1\u5e03\u8d77\uff0c\u6b66\u6c49\u5df2\u5efa\u7acb 13 \u6240\u65b9\u8231\u533b\u9662\uff0c\u7d2f\u8ba1\u6709\u4e0a\u4e07\u5f20\u5e8a\u4f4d\u5c31\u7eea\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u867d\u7136\u5165\u4f4f\u60a3\u8005\u5747\u5df2\u786e\u8bca\uff0c\u4f46<\/span>\u65b9\u8231\u5185\u90e8\u8fc7\u5927\u7684\u75c5\u5e8a\u5bc6\u5ea6\u4ecd\u53ef\u80fd\u9762\u4e34\u5927\u7a7a\u95f4\u7684\u611f\u63a7\u7ba1\u7406\u95ee\u9898<\/span>\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u91cd\u7ec4\u662f\u75c5\u6bd2\u8fdb\u5316\u7684\u91cd\u8981\u624b\u6bb5\u3002\u5f53\u591a\u79cd\u4eb2\u7f18\u5173\u7cfb\u76f8\u8fd1\u7684\u75c5\u6bd2\u4fb5\u5165\u540c\u4e00\u4e2a\u5bbf\u4e3b\u7ec6\u80de\u65f6\uff0c\u5b83\u4eec\u6709\u6982\u7387\u4f1a\u4e92\u6362\u9057\u4f20\u7269\u8d28\u7247\u6bb5\uff0c\u878d\u5408\u65b0\u75c5\u6bd2 <\/span>[1]<\/span>\uff0c\u800c\u8fd9\u79cd\u65b0\u75c5\u6bd2\u6709\u4e00\u5b9a\u53ef\u80fd\u662f\u4f20\u64ad\u529b\u81f4\u75c5\u529b\u66f4\u5f3a\u7684\u300c\u8d85\u7ea7\u75c5\u6bd2\u300d<\/span>[2]<\/span>\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u8fd9\u79cd\u75c5\u6bd2\u7684\u91cd\u7ec4\u5728\u4f20\u67d3\u75c5\u5b66\u4e2d\u5e76\u4e0d\u5c11\u89c1\uff0c\u8457\u540d\u7684 HIV \u8d85\u7ea7\u611f\u67d3\uff08superinfection\uff09<\/span>[3]<\/span> \u5c31\u662f\u51fa\u73b0\u5728\u611f\u67d3\u4e86\u591a\u682a HIV \u75c5\u6bd2\u7684\u60a3\u8005\u4e2d\u3002<\/span><\/section>\n

<\/section>\n
HIV \u75c5\u6bd2\u591a\u6b21\u91cd\u7ec4\u540e\u4ea7\u751f\u7a81\u53d8\u578b\uff0c\u9003\u907f\u514d\u75ab\u7ec6\u80de\u7684\u76d1\u89c6\u5e76\u4f7f\u75c5\u60c5\u6076\u5316\u3002SARS \u75c5\u6bd2\u57fa\u56e0\u7ec4\u4e2d\u6709\u8d85\u8fc7 7 \u4e2a\u91cd\u7ec4\u533a\u57df\u4f4d\u4e8e\u590d\u5236\u9176\u548c Spike \u7f16\u7801\u533a\u57df\uff0c\u5bfc\u81f4\u6f5c\u5728\u7684\u5bbf\u4e3b\u8303\u56f4\u6269\u5927\u98ce\u9669\u3002<\/span><\/section>\n

<\/span><\/section>\n
\"\u6b66\u6c49\u65b9\u8231\u9996\u6279\u60a3\u8005\u51fa\u9662\uff1a\u5efa\u7acb\u65b9\u8231\u80cc\u540e\u7684\u903b\u8f91\u662f\u4ec0\u4e48\uff1f\"<\/section>\n
HIV \u8d85\u7ea7\u611f\u67d3\u6a21\u5f0f\u56fe\uff08\u56fe\u6e90\uff1a<\/span>\u53c2\u8003\u6587\u732e 3\uff09<\/span><\/section>\n

<\/section>\n
\u6b64\u524d\u5df2\u6709\u7814\u7a76\u62a5\u9053\uff0cSARS-CoV\u3001Ro-BatCoV \u7b49\u591a\u79cd\u51a0\u72b6\u75c5\u6bd2\u5b58\u5728\u91cd\u7ec4 <\/span>[4]<\/span>\uff0c<\/span>\u4f46\u76ee\u524d\u8fd8\u6ca1\u6709\u8bc1\u636e\u663e\u793a \u65b0\u51a0\u75c5\u6bd2\u6765\u81ea\u91cd\u7ec4\uff0c\u5176\u8fdb\u5316\u7279\u6027\u5c1a\u4e0d\u660e\u786e\u3002<\/span><\/strong>[5<\/span>]<\/span><\/span><\/section>\n
 <\/span><\/section>\n
\u9488\u5bf9\u65b9\u8231\u533b\u9662\u5e8a\u5747\u95f4\u9694\u5c0f\u3001\u75c5\u4eba\u76f8\u4e92\u4ea4\u6d41\u5bc6\u5207\u7684\u7279\u70b9\uff0c\u8bbe\u65bd\u5185\u826f\u597d\u7684\u901a\u98ce\u6392\u6c14\u3001\u75c5\u4eba\u95f4\u4e25\u5bc6\u7684\u4e2a\u4eba\u9632\u62a4\uff08\u6234\u53e3\u7f69\uff09\u548c\u533b\u62a4\u7ed9\u4e88\u7684\u53ca\u65f6\u6cbb\u7597\u5219\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6700\u5f00\u59cb\u5efa\u8bbe\u7684\u65b9\u8231\u533b\u9662\u91c7\u7528\u7684\u662f\u5f81\u7528\u4f53\u80b2\u9986\u7b49\u5927\u578b\u573a\u9986\u7684\u505a\u6cd5\uff0c\u4f46\u540e\u7eed\u65b0\u5efa\u7acb\u7684\u65b9\u8231\u5f00\u59cb\u4ee5\u5b66\u751f\u5bbf\u820d\u3001\u6559\u5ba4\u4e3a\u4e3b\uff0c\u9009\u62e9\u8fd9\u79cd\u81ea\u5e26\u9694\u65ad\u5efa\u7b51\uff0c\u80fd\u5c3d\u53ef\u80fd\u51cf\u5c11\u60a3\u8005\u4e4b\u95f4\u76f8\u4e92\u611f\u67d3\u7684\u98ce\u9669\uff0c\u540c\u65f6\u4e5f\u80fd\u6539\u5584\u4f4f\u5bbf\u6761\u4ef6\u3002<\/span><\/section>\n

<\/span><\/section>\n
\"\u6b66\u6c49\u65b9\u8231\u9996\u6279\u60a3\u8005\u51fa\u9662\uff1a\u5efa\u7acb\u65b9\u8231\u80cc\u540e\u7684\u903b\u8f91\u662f\u4ec0\u4e48\uff1f\"<\/section>\n
\u5efa\u8bbe\u5728\u5927\u578b\u573a\u9986\u5185\u7684\u65b9\u8231\u533b\u9662<\/span><\/section>\n
\uff08\u56fe\u6e90\uff1a\u592e\u89c6\u65b0\u95fb\uff09<\/span><\/section>\n

<\/span><\/section>\n
\u65b9\u8231\u5185\u7684\u533b\u7597\u56e2\u961f\u540c\u6837\u8d23\u4efb\u91cd\u5927\uff1a<\/span>\u76d1\u62a4\u6bcf\u4e00\u4f4d\u75c5\u4eba\u7684\u751f\u547d\u4f53\u5f81\uff0c\u75c5\u60c5\u6076\u5316\u8005\u8fc5\u901f\u5165\u9662\uff0c\u75c7\u72b6\u6d88\u5931\u4e14\u6838\u9178\u8f6c\u9634\u8005\u8003\u8651\u51fa\u8231\uff0c<\/span>\u5efa\u7acb\u65b9\u8231\u5185\u7684\u52a8\u6001\u5e73\u8861\uff0c<\/span>\u8ba9\u8f7b\u75c7\u60a3\u8005\u7684\u51fa\u9662\u901f\u5ea6\u5feb\u4e8e\u75c5\u6bd2\u6f5c\u5728\u7684\u91cd\u7ec4\u901f\u5ea6\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
\u975e\u81f3\u5584\u4e4b\u4e3e\uff0c\u5374\u662f\u73b0\u5b9e\u4e4b\u7b56<\/strong><\/span><\/span><\/section>\n
<\/span><\/section>\n

<\/span><\/section>\n
\u738b\u8fb0\u9662\u58eb\u8fd9\u6837\u5f62\u5bb9\u65b9\u8231\uff1a\u975e\u81f3\u5584\u4e4b\u4e3e\uff0c\u4f46\u662f\u975e\u5e38\u65f6\u671f\u7684\u73b0\u5b9e\u4e4b\u7b56\u3001\u5173\u952e\u4e4b\u7b56\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u663e\u7136\uff0c\u521a\u521a\u6577\u8bbe\u5b8c\u6210\u7684\u65b9\u8231\u8fd8\u6709\u65b9\u65b9\u9762\u9762\u7684\u95ee\u9898\u4e9f\u5f85\u89e3\u51b3\uff0c\u4e00\u4e9b\u751f\u6d3b\u8bbe\u65bd\u4e0d\u5b8c\u5584\u3001\u4eba\u5458\u8bad\u7ec3\u4e0d\u5230\u4f4d\u7684\u65b9\u8231\u4e5f\u88ab\u5306\u5306\u6295\u5165\u4f7f\u7528\u3002<\/span><\/section>\n

<\/section>\n
\u5728\u4e0a\u5343\u540d\u8f7b\u75c7\u60a3\u8005\u5feb\u901f\u6d8c\u5165\u65b9\u8231\u7684\u78e8\u5408\u671f\uff0c\u7f51\u7edc\u4e0a\u51fa\u73b0\u4e86\u8bb8\u591a\u65b9\u8231\u5185\u4fdd\u6696\u63aa\u65bd\u6b20\u7f3a\u3001\u5982\u5395\u6392\u961f\u8fc7\u957f\u3001\u533b\u52a1\u4eba\u5458\u4e0d\u8db3\u7684\u6d88\u606f\u3002<\/span><\/section>\n

<\/section>\n
\"\u6b66\u6c49\u65b9\u8231\u9996\u6279\u60a3\u8005\u51fa\u9662\uff1a\u5efa\u7acb\u65b9\u8231\u80cc\u540e\u7684\u903b\u8f91\u662f\u4ec0\u4e48\uff1f\"<\/section>\n
\u793e\u4ea4\u5a92\u4f53\u663e\u793a\uff0c\u6b66\u6c49\u90e8\u5206\u65b9\u8231\u533b\u9662\u7684\u751f\u6d3b\u6761\u4ef6\u4ecd\u5f85\u6539\u5584<\/span><\/section>\n
<\/span><\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u867d\u7136\u5bf9\u4e8e\u73b0\u9636\u6bb5\u7684\u65b9\u8231\u800c\u8a00\uff0c<\/span>\u7784\u51c6\u7684<\/span>\u662f<\/span>\u6838\u5fc3\u5173\u7a8d\u300c<\/span>\u9694\u79bb\u4f20\u67d3\u6e90\u3001\u65a9\u65ad\u4f20\u64ad\u9014\u5f84\u300d\uff0c\u4f46\u5bf9\u4e8e<\/span>\u65b9\u8231\u5185\u533b\u60a3\u7684\u5fc3\u7406\u5e72\u9884\u4e0e\u60c5\u7eea\u5f15\u5bfc\u4e5f\u4e0d\u53ef\u8f7b\u89c6\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u4e8b\u5b9e\u4e0a\uff0c\u5bb9\u7eb3\u8fd1\u5343\u4eba\u7684\u65b9\u8231\u5185\u5f88\u5bb9\u6613\u51fa\u73b0\u7fa4\u4f53\u6027\u6050\u614c\u6216\u8fc7\u6fc0\u884c\u4e3a\uff0c\u9020\u6210\u7c7b\u4f3c\u300c\u9ea6\u52a0\u8e29\u8e0f\u300d\u7684\u7fa4\u4f53\u6027\u4e8b\u4ef6\u60b2\u5267\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4e3a\u6b64\uff0c\u65b9\u8231\u9700\u8981\u5feb\u901f\u5b8c\u5584\u65b9\u8231\u751f\u6d3b<\/span>\u6761\u4ef6\uff0c\u7ef4\u6301\u540e\u52e4\u4f9b<\/span>\u7ed9\uff1b<\/span>\u6d3e\u9a7b\u4e13\u4e1a\u7684\u5fc3\u7406\u54a8\u8be2\u4ece\u4e1a\u8005\u8fdb\u884c\u5fc3\u7406\u5e72\u9884\uff0c\u533b\u60a3\u53cc\u65b9\u90fd\u9700\u8981\u66f4\u591a\u7684\u8010\u5fc3\u4e0e\u5173\u5fc3\uff1b\u4e3a\u5e94\u5bf9\u7a81\u53d1\u5c40\u9762\uff0c\u8fd8\u9700\u5b89\u6392\u4eba\u529b\u7ef4\u6301\u79e9\u5e8f\u3002<\/span><\/section>\n

<\/span><\/span><\/section>\n
\u636e\u5076\u5c14\u6cbb\u6108\u56e2\u961f\u62a5\u9053\uff0c<\/span>\u6b66\u660c\u65b9\u8231\u961f\u957f\u3001\u6b66\u6c49\u4eba\u6c11\u533b\u9662\u526f\u9662\u957f\u4e07\u519b\u544a\u8bc9\u5076\u5c14\u6cbb\u6108\uff0c\u5728\u610f\u8bc6\u5230\u5fc3\u7406\u758f\u5bfc\u95ee\u9898\u540e\uff0c\u6b66\u6c49\u4eba\u6c11\u533b\u9662\u548c\u6e58\u96c5\u4e8c\u9662\u4e00\u540c\u8fde\u591c\u7f16\u5236\u4e86\u5fc3\u7406\u624b\u518c\u5e76\u5f71\u5370\u4e86 1000 \u518c\uff0c\u5c06\u9646\u7eed\u53d1\u653e\u7ed9\u60a3\u8005\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6c5f\u6c49\u65b9\u8231\u961f\u957f\u3001\u6b66\u6c49\u534f\u548c\u533b\u9662\u526f\u4e66\u8bb0\u5b59\u6656\u544a\u8bc9\u5076\u5c14\u6cbb\u6108\uff0c\u4ed6\u4eec\u8ba1\u5212\u901a\u8fc7\u573a\u9986\u97f3\u54cd\u65e9\u4e2d\u665a\u4e09\u6b21\u8fdb\u884c\u5e7f\u64ad\u5fc3\u7406\u758f\u5bfc\uff0c\u5e76\u5c06\u5efa\u7acb\u60a3\u8005\u793e\u533a\u8fdb\u884c\u4e92\u52a9\u81ea\u6cbb\u3002<\/span><\/section>\n

<\/span><\/section>\n
\"\u6b66\u6c49\u65b9\u8231\u9996\u6279\u60a3\u8005\u51fa\u9662\uff1a\u5efa\u7acb\u65b9\u8231\u80cc\u540e\u7684\u903b\u8f91\u662f\u4ec0\u4e48\uff1f\"<\/section>\n
\u65b9\u8231\u5185\u7684\u533b\u52a1\u4eba\u5458\u548c\u60a3\u8005\u4e00\u8d77\u505a\u64cd<\/span><\/section>\n
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1.Good B H , Mcdonald M J , Barrick J E , et al. The Dynamics of Molecular Evolution Over 60,000 Generations[J]. Nature, 2017, 551(7678).<\/span>
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2.Lang GI, Rice DP, Hickman MJ, Sodergren E, Weinstock GM, Botstein D, Desai MM. Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations[J]. Nature, 2013, 500: 571\u2013574.<\/span>
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3.Sheward DJ, Marais J, Bekker V, et al. HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth[J]. Host & Microbe, 2018.<\/span>
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4.Huang C , Liu W J , Xu W , et al. A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene[J]. PLoS Pathogens, 2016, 12(9):e1005883.<\/span><\/section>\n
5.Paraskevis D, Kostaki EG, Magiorkinis G, et al. Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infect Genet Evol. 2020 ;79:104212. doi: 10.1016\/j.meegid.2020.104212.<\/span><\/section>\n

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