{"id":133802,"date":"2020-02-19T05:51:05","date_gmt":"2020-04-21T03:26:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/133802\/"},"modified":"2020-04-21T11:26:03","modified_gmt":"2020-04-21T03:26:03","slug":"6b3ef19534","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/133802\/","title":{"rendered":"\u7b2c\u516d\u7248\u65b9\u6848\u65b0\u589e\u7684\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u662f\u4e0d\u662f\u7279\u6548\u836f\uff1f"},"content":{"rendered":"
\n
\n

<\/section>\n<\/section>\n
\"\u7b2c\u516d\u7248\u65b9\u6848\u65b0\u589e\u7684\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u662f\u4e0d\u662f\u7279\u6548\u836f\uff1f\"<\/section>\n

<\/span><\/strong><\/span><\/section>\n
\n
\n
2 \u6708 17 \u65e5\u4e0b\u5348\uff0c\u56fd\u52a1\u9662\u8054\u9632\u8054\u63a7\u673a\u5236\u53ec\u5f00\u53d1\u5e03\u4f1a\uff0c\u79d1\u6280\u90e8\u751f\u7269\u4e2d\u5fc3\u526f\u4e3b\u4efb\u5b59\u71d5\u8363\u5728\u4f1a\u4e0a\u8868\u793a\uff1a\u7597\u6548\u4e13\u5bb6\u7ec4\u7ecf\u8fc7\u8ba4\u771f\u7ec6\u81f4\u7684\u7814\u8ba8\uff0c\u6700\u540e\u8fbe\u6210\u4e00\u81f4\u610f\u89c1\uff0c\u4e00\u81f4\u8ba4\u4e3a\u78f7\u9178\u6c2f\u55b9\u662f\u4e00\u4e2a\u4e0a\u5e02\u591a\u5e74\u7684\u8001\u836f\uff0c\u7528\u4e8e\u5e7f\u6cdb\u4eba\u7fa4\u6cbb\u7597\u7684\u5b89\u5168\u6027\u662f\u53ef\u63a7\u7684\u3002\u57fa\u4e8e\u524d\u671f\u4e34\u5e8a\u673a\u6784\u6240\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u7ed3\u679c\u53ef\u4ee5\u660e\u786e\u78f7\u9178\u6c2f\u55b9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u5177\u6709\u7597\u6548\uff0c\u4e14\u672a\u53d1\u73b0\u548c\u836f\u7269\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002<\/strong>\u57fa\u4e8e\u5f53\u524d\u4e34\u5e8a\u6551\u6cbb\u7684\u8feb\u5207\u9700\u6c42\uff0c\u4e13\u5bb6\u4e00\u81f4\u63a8\u8350\uff0c\u5e94\u5f53\u5c3d\u5feb\u5c06\u78f7\u9178\u6c2f\u55b9\u7eb3\u5165\u5230\u65b0\u4e00\u7248\u7684\u8bca\u7597\u6307\u5357\uff0c\u6269\u5927\u4e34\u5e8a\u9002\u7528\u8303\u56f4\u3002<\/span><\/section>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n

<\/span><\/strong><\/section>\n
\u78f7\u9178\u6c2f\u55b9\u662f\u4ec0\u4e48\u836f\uff1f<\/span><\/strong><\/span>
<\/section>\n


<\/span><\/p>\n


<\/span><\/p>\n

\u6c2f\u55b9\u662f\u4e00\u79cd\u6297\u759f\u836f\uff0c\u6700\u521d\u7528\u4e8e\u63a7\u5236\u759f\u75be\u75c7\u72b6\u548c\u6cbb\u7597\u80a0\u5916\u963f\u7c73\u5df4\u75c5\uff0c\u5728\u4e34\u5e8a\u4e0a\u5df2\u7ecf\u4f7f\u7528\u4e86 70 \u591a\u5e74\u3002<\/span><\/section>\n


<\/span><\/p>\n

2003 \u5e74\u975e\u5178\u671f\u95f4\uff0c\u56fd\u5916\u6709\u7814\u7a76\u53d1\u73b0\uff1a\u6c2f\u55b9\u53ef\u6709\u6548\u9884\u9632\u548c\u963b\u6b62 SARS \u75c5\u6bd2\u5728\u7ec6\u80de\u4e2d\u7684\u590d\u5236\u3002<\/span><\/section>\n


<\/span><\/p>\n

\"\u7b2c\u516d\u7248\u65b9\u6848\u65b0\u589e\u7684\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u662f\u4e0d\u662f\u7279\u6548\u836f\uff1f\"<\/section>\n
\u300c\u7528\u836f\u52a9\u624bAPP\u300d\u641c\u7d22\u300c\u78f7\u9178\u6c2f\u55b9\u300d<\/span><\/section>\n


<\/p>\n


<\/p>\n


<\/p>\n

\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u662f\u7279\u6548\u836f\u5417\uff1f<\/span><\/strong><\/span><\/section>\n


<\/p>\n


<\/p>\n

\u901a\u8fc7\u7cfb\u7edf\u68c0\u7d22PubMed\u3001EMbase\u3001Cochrane\u3001\u4e2d\u56fd\u77e5\u7f51\u3001\u7ef4\u666e\u53ca\u4e07\u65b9\u6570\u636e\u5e93\uff0c\u6211\u4eec\u5c1d\u8bd5\u4ece\u8be2\u8bc1\u7684\u89d2\u5ea6\u53bb\u63a2\u7d22\u6c2f\u55b9\u7528\u4e8e CoVID-19 \u6cbb\u7597\u7684\u8bc1\u636e\u3002<\/span><\/section>\n


<\/p>\n

\u76f4\u63a5\u8bc1\u636e<\/strong><\/span><\/section>\n


<\/span><\/p>\n

\u4e00\u9879\u4f53\u5916\u7814\u7a76\u663e\u793a[1]\uff0c\u6c2f\u55b9\u80fd\u591f\u6709\u6548\u6291\u5236 CoVID-19\uff0cEC50=1.13\u03bcM\uff0cCC50\uff1e100\u03bcM\uff0cSI\uff1e88.50\u3002\u5176\u5728 Vero E6 \u7ec6\u80de\u4e2d\u6297 CoVID-19 \u7684 EC90 \u4e3a 6.90\u03bcM\uff0c\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u7ed9\u4e88 500mg \u6c2f\u55b9\u65f6\uff0c\u8840\u6d46\u4e2d\u5c31\u53ef\u4ee5\u5230\u8fbe\u8fd9\u4e2a\u6d53\u5ea6[2]\u3002<\/span><\/section>\n


<\/span><\/p>\n

\"\u7b2c\u516d\u7248\u65b9\u6848\u65b0\u589e\u7684\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u662f\u4e0d\u662f\u7279\u6548\u836f\uff1f\"<\/section>\n
\u78f7\u9178\u6c2f\u55b9\u5bf9\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff082019-nCoV\uff09<\/span><\/section>\n
\u4f53\u5916\u6297\u75c5\u6bd2\u6d3b\u6027\u6d4b\u8bd5\u7ed3\u679c<\/span><\/section>\n


<\/span><\/p>\n

\u95f4\u63a5\u8bc1\u636e<\/strong><\/span><\/section>\n


<\/p>\n

\u5bf9\u4e8e SARS-CoV\uff0c\u591a\u9879\u4f53\u5916\u7814\u7a76[3][4][5]\u663e\u793a\uff0c\u6c2f\u55b9\u80fd\u591f\u6709\u6548\u6291\u5236 SARS-CoV\uff0cEC50=4.1\u03bc<\/span>M\u3002<\/span><\/section>\n


<\/p>\n

\u5bf9\u4e8e MERS-CoV\uff0c\u4e00\u9879\u4f53\u5916\u7814\u7a76[3]\u663e\u793a\uff0c\u6c2f\u55b9\u5bf9 MERS-COV \u590d\u5236\u7684\u6291\u5236\u4f5c\u7528\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\uff0cEC50=3.0\u03bc<\/span>M\uff0cSI=19.4\u3002<\/span><\/section>\n


<\/p>\n

\u6c2f\u55b9\u6709\u76f4\u63a5\u7684\u57fa\u7840\u7814\u7a76\u8bc1\u636e\uff0c\u4f46\u5747\u4e3a\u4f53\u5916\u7814\u7a76\u7ed3\u679c\uff0c\u76ee\u524d\u5df2\u542f\u52a8\u591a\u9879 RCT\uff08NCT04261517\u3001ChiCTR2000029763\u3001ChiCTR2000029740\u3001ChiCTR2000029559\u3001ChiCTR2000029762\u3001ChiCTR2000029761\uff09\u8bc4\u4ef7\u6c2f\u55b9\u548c\u7f9f\u6c2f\u55b9\u6cbb\u7597 CoVID-19 \u611f\u67d3\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\uff0c\u5e76\u5bf9\u4e0d\u540c\u5242\u91cf\u7f9f\u6c2f\u55b9\u7684\u7597\u6548\u8fdb\u884c\u63a2\u7d22\u3002<\/span><\/section>\n


<\/span><\/p>\n

\u4e13\u5bb6\u610f\u89c1<\/span><\/strong><\/span><\/p>\n


<\/section>\n
2 \u6708 18 \u65e5\uff0c\u949f\u5357\u5c71\u9662\u58eb\u5728\u65b0\u95fb\u53d1\u5e03\u4f1a\u4e0a\u8868\u793a\uff1a\u78f7\u9178\u6c2f\u55b9\u591f\u4e0d\u4e0a\u7279\u6548\u836f\uff0c\u4f46\u6709\u6cbb\u7597\u6548\u679c\uff0c\u503c\u5f97\u7814\u7a76\u548c\u63a2\u8ba8\u3002
<\/span><\/section>\n


<\/p>\n


<\/p>\n


<\/p>\n

\u4e34\u5e8a\u4f7f\u7528\u78f7\u9178\u6c2f\u55b9\u65f6\u9700\u6ce8\u610f\u4ec0\u4e48\uff1f<\/span><\/strong>[6]<\/span><\/strong><\/span><\/section>\n


<\/p>\n


<\/p>\n

\u78f7\u9178\u6c2f\u55b9<\/span>\u7528\u4e8e\u6cbb\u7597\u759f\u75be\u65f6\uff0c\u4e0d\u826f\u53cd\u5e94\u8f83\u5c11\uff0c\u53e3\u670d\u4e00\u822c\u53ef\u80fd\u51fa\u73b0\u7684\u53cd\u5e94\u6709\uff1a<\/span>\u5934\u6655\u3001\u5934\u75db\u3001\u773c\u82b1\u3001\u98df\u6b32\u51cf\u9000\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u75db\u3001\u8179\u6cfb\u3001\u76ae\u80a4\u7619\u75d2\u3001\u76ae\u75b9\u3001\u751a\u81f3\u5265\u8131\u6027\u76ae\u708e\u3001\u8033\u9e23\u3001\u70e6\u8e81\u7b49\u3002<\/span>\u53cd\u5e94\u5927\u591a\u8f83\u8f7b\uff0c\u505c\u836f\u540e\u53ef\u81ea\u884c\u6d88\u5931\u3002<\/span><\/section>\n


<\/span><\/p>\n

\u4f46<\/span>\u7528\u836f\u91cf\u5927\u3001\u7597\u7a0b\u957f\u65f6\uff0c\u53ef\u80fd\u4f1a\u6709\u8f83\u91cd\u7684\u53cd\u5e94\uff1b\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\uff0c\u4e5f\u5b58\u5728\u8f83\u591a\u7684\u6ce8\u610f\u4e8b\u9879\u548c\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/section>\n


<\/span><\/p>\n

\u70b9\u51fb\u300c\u9605\u8bfb\u539f\u6587\u300d\u67e5\u770b\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u7684\u5b8c\u6574\u7528\u836f\u8bf4\u660e\u3002<\/span><\/strong><\/span><\/section>\n
<\/span><\/section>\n


<\/p>\n

\n
\n

<\/section>\n<\/section>\n<\/section>\n
\u7f16\u8f91 | \u5341\u4e00<\/span><\/section>\n
\u6295\u7a3f | liuyumeng1@dxy.cn<\/span><\/section>\n


<\/span><\/p>\n

\"\u7b2c\u516d\u7248\u65b9\u6848\u65b0\u589e\u7684\u300c\u78f7\u9178\u6c2f\u55b9\u300d\u662f\u4e0d\u662f\u7279\u6548\u836f\uff1f\"<\/section>\n
\n
\n
\u53c2\u8003\u6587\u732e\uff08\u4e0a\u4e0b\u6ed1\u52a8\u67e5\u770b\uff09<\/span><\/strong><\/section>\n
[1]WANG M, CAO R, ZHANGL, et al. Remdesivir and chloroquine effectively inhibit the recently emergednovel coronavirus (2019-nCoV) in vitro [J]. Research, 2020,<\/span><\/section>\n
[2]MackenzieAH. Dose refinements in long-term therapy of rheumatoid arthritis withantimalarials [J]. Am. J. Med, 1983, 75: 40\u201345.<\/span><\/section>\n
[3]de Wilde AH, Jochmans D,Posthuma CC, et al. Screening of an FDA-approved compound library identifiesfour small-molecule inhibitors of middle east respiratory syndrome coronavirusreplication in cell culture [J]. Antimicrob Agents Chemother. 2014;58(8):p 4875.<\/span><\/section>\n
[4]van den Worm SH, Eriksson KK,  Zevenhoven JC, et al. Reverse genetics of SARS-related coronavirus using vacciniavirus-based recombination [J]<\/span>. PLoS One , 2012,<\/span><\/cite>7<\/span>:<\/span><\/cite>e32857<\/span>.<\/span><\/cite><\/section>\n
[5]Keyaerts E,  Vijgen L,  Maes P, et al.<\/span> <\/span><\/cite>In vitro inhibition of severe acute respiratory syndromecoronavirus by chloroquine [J]<\/span>. Biochem. Biophys. Res.Commun. 2004, <\/span><\/cite>323<\/span>:<\/span><\/cite>264<\/span>\u2013<\/span><\/cite>268<\/span>.<\/span><\/cite><\/section>\n
[6]\u78f7\u9178\u6c2f\u55b9\u8bf4\u660e\u4e66.\u7528\u836f\u52a9\u624bAPP<\/span><\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

2 \u6708 17 \u65e5\u4e0b\u5348\uff0c\u56fd\u52a1\u9662\u8054\u9632\u8054\u63a7\u673a\u5236\u53ec\u5f00\u53d1\u5e03\u4f1a\uff0c\u79d1\u6280\u90e8\u751f\u7269\u4e2d\u5fc3\u526f\u4e3b\u4efb\u5b59\u71d5\u8363\u5728\u4f1a\u4e0a\u8868\u793a\uff1a\u7597\u6548\u4e13\u5bb6\u7ec4\u7ecf\u8fc7\u8ba4\u771f\u7ec6 […]<\/p>\n","protected":false},"author":1,"featured_media":133803,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/133802"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=133802"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/133802\/revisions"}],"predecessor-version":[{"id":133808,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/133802\/revisions\/133808"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/133803"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=133802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=133802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=133802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}