{"id":134082,"date":"2020-02-24T11:59:51","date_gmt":"2020-04-21T03:28:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/134082\/"},"modified":"2020-04-21T11:28:51","modified_gmt":"2020-04-21T03:28:51","slug":"f80859234b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/134082\/","title":{"rendered":"\u5fc5\u7136\u4e4b\u4e2d\u5bfb\u627e\u65b0\u7684\u7a81\u7834\u53e3\uff01\u4e00\u4f8b\u75ca\u6108\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5e26\u6765\u7684\u601d\u8003"},"content":{"rendered":"
\n
\u75ca\u6108\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7684\u7528\u836f\u4e4b\u4e00<\/strong>\uff1a\u6309\u7167\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u56db\u7248\uff09\u300b\uff0c\u56db\u5ddd\u9996\u4f8b\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u60a3\u8005\u5728\u7ed9\u4e88\u6297\u75c5\u6bd2\u3001\u6297\u611f\u67d3\u7b49\u5bf9\u75c7\u5904\u7406\u7684\u540c\u65f6\u96fe\u5316 NAC\uff0c\u5728\u7701\u5e02\u4e13\u5bb6\u6307\u5bfc\u4e0b\uff0c\u7ecf\u8fc7\u5168\u4f53\u533b\u52a1\u4eba\u5458\u79ef\u6781\u6551\u6cbb\uff0c\u60a3\u8005\u68c0\u6d4b\u7ed3\u679c\u7b26\u5408\u56fd\u5bb6\u536b\u5065\u59d4\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u56db\u7248\uff09\u300b\u89e3\u9664\u9694\u79bb\u6cbb\u7597\u6807\u51c6\uff0c\u75c7\u72b6\u6d88\u5931\uff0c\u75c5\u60c5\u75ca\u6108\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u9884\u9632\u65b0\u51a0\u80ba\u708e\u7684\u50a8\u5907\u836f\u54c1\u4e4b\u4e00\uff1a<\/strong>\u5728\u6297\u51fb\u65b0\u51a0\u80ba\u708e\u6551\u6cbb\u524d\u7ebf\u4f20\u6765\u6d88\u606f\uff0c\u6b66\u6c49\u706b\u795e\u5c71\u548c\u96f7\u795e\u5c71\u533b\u9662\u5728\u6b63\u5f0f\u6536\u6cbb\u75c5\u4eba\u524d\u7d27\u6025\u91c7\u8d2d\u4e86 N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\uff08N-acetylcysteine\uff0cNAC\uff09\u7b49\u5176\u4ed6\u836f\u7269\u7528\u4e8e\u9884\u9632\u300c\u65b0\u51a0\u80ba\u708e\u300d\u7684\u50a8\u5907\u836f\u54c1\u3002<\/span><\/section>\n

<\/span><\/section>\n

\"\u5fc5\u7136\u4e4b\u4e2d\u5bfb\u627e\u65b0\u7684\u7a81\u7834\u53e3\uff01\u4e00\u4f8b\u75ca\u6108\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5e26\u6765\u7684\u601d\u8003\"<\/p>\n


<\/section>\n
N-<\/strong>\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u4eae\u76f8\u5e76\u975e\u5076\u7136<\/strong><\/strong><\/span><\/section>\n

<\/strong><\/span><\/section>\n
NAC \u5206\u5b50\u5f0f\u4e3a C5 H9N03S\uff0c\u5206\u5b50\u91cf\u4e3a 163.2\uff0c\u662f L-\u534a\u80f1\u6c28\u9178\u7684\u4e59\u9170\u5316\u5408\u7269, \u5176\u542b\u6709\u6d3b\u8dc3\u7684-SH \u57fa\u3002<\/span>\u4e0d\u53ef\u5c0f\u770b\u8fd9\u4e00\u57fa\u56e2\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u795b\u75f0\u754c\u7eb5\u6a2a\u51e0\u5341\u5e74\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e-SH \u57fa\u5bf9\u4e8c\u786b\u952e\u7684\u65ad\u952e\u4f5c\u7528\u3002<\/span>\u300a\u9488\u5bf9\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u60a3\u8005\u7684\u96fe\u5316\u5438\u5165\u6cbb\u7597\u7684\u5efa\u8bae\u300b<\/span>\u63d0\u5230\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u53ef\u4e3a\u65b0\u51a0\u80ba\u708e\u96fe\u5316\u5438\u5165\u5e38\u7528\u836f\u7269\u4e4b\u4e00\uff0c\u53ef\u964d\u4f4e\u75f0\u6db2\u9ecf\u6ede\u6027\uff0c\u6eb6\u89e3\u8113\u6027\u75f0\uff0c\u6709\u6548\u6539\u5584\u7ea4\u6bdb\u8fd0\u52a8\uff0c\u589e\u5f3a\u7ea4\u6bdb\u6e05\u9664\u529f\u80fd\uff0c\u589e\u52a0\u80ba\u6ce1\u8868\u9762\u6d3b\u6027\u7269\u8d28\uff0c\u8fd8\u53ef\u5f71\u54cd\u9ecf\u6db2\u751f\u6210\u3002\u6b64\u5916\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u4f5c\u4e3a\u6297\u6c27\u5316\u5242\u8c37\u80f1\u7518\u80bd\u7684\u524d\u4f53\u836f\u7269\uff0c\u5728\u5916\u5468\u6c14\u9053\u53ef\u4ee5\u53d1\u6325\u6e05\u9664\u6c27\u81ea\u7531\u57fa\u7684\u4f5c\u7528\uff0c\u6291\u5236\u7ec6\u83cc\u751f\u7269\u819c\u5f62\u6210\uff0c\u7834\u574f\u5df2\u5f62\u6210\u751f\u7269\u819c\uff0c\u534f\u540c\u6297\u751f\u7d20\u6709\u6548\u6297\u83cc\u3002\u786e\u5b9e\uff0c\u968f\u7740\u65f6\u95f4\u7684\u8fdb\u5c55\u548c\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u591a\u79cd\u836f\u7406\u4f5c\u7528\u88ab\u91cd\u65b0\u8ba4\u8bc6\uff0c\u5176\u4ed6\u6f5c\u529b\u4e5f\u4e0d\u65ad\u88ab\u53d1\u73b0\u5e76\u5e94\u7528\u5230\u4e34\u5e8a\u3002<\/span><\/span><\/span><\/section>\n

<\/section>\n
19 \u4e16\u7eaa 60 \u5e74\u4ee3\u521d\uff0cNAC \u5c31\u4f5c\u4e3a\u9ecf\u6db2\u6eb6\u89e3\u5242\u7528\u4e8e\u547c\u5438\u7cfb\u7edf\u75be\u75c5 [1]<\/sup>\u3002<\/span><\/span><\/section>\n
19 \u4e16\u7eaa 70 \u5e74\u4ee3\u672b\uff0c\u53d1\u73b0 NAC \u5177\u6709\u809d\u810f\u7ec6\u80de\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u89e3\u70ed\u9547\u75db\u836f-\u4e59\u9170\u6c28\u57fa\u915a\u7684\u809d\u810f\u6bd2\u6027\u635f\u4f24 [2]<\/sup>\u3002<\/span><\/span><\/section>\n
19 \u4e16\u7eaa 90 \u5e74\u4ee3\u4e2d\u671f\uff0c\u53d1\u73b0 NAC \u5177\u6709\u6297\u6c27\u5316\u4f5c\u7528 [3]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/section>\n
\u6df1\u5165\u601d\u8003\uff1a<\/strong>\u4e3a\u4f55 N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u53ef\u4ee5\u6210\u4e3a\u547c\u5438\u9886\u57df\u7684\u591a\u9762\u624b\uff1f<\/strong><\/span><\/section>\n

<\/section>\n
1.1 \u6297\u6c27\u5316\uff1a<\/strong><\/strong><\/strong><\/strong>\u4fdd\u62a4\u7ec6\u80de\uff0c\u514d\u53d7\u635f\u5bb3<\/strong><\/strong><\/span><\/section>\n

<\/section>\n
\u76f4\u63a5\u6297\u6c27\u5316\uff1a<\/strong>\u4f53\u5185\u7684-SH \u6c27\u5316\u8fd8\u539f\u662f\u7ef4\u6301\u7ec6\u80de\u7684\u6c27\u5316\u8fd8\u539f\u7a33\u6001\uff0c\u6297\u8fc7\u6c27\u5316\u635f\u4f24\u7684\u91cd\u8981\u673a\u5236\u3002NAC \u5206\u5b50\u4e2d\u542b\u6709\u6d3b\u6027-SH\uff0c\u901a\u8fc7\u5def\u57fa\u4e0e\u4e00\u4e9b\u6c27\u5316\u5242\uff0c\u5982 NO2 \u548c HOX \u76f8\u4e92\u4f5c\u7528\uff0c\u53d1\u6325\u76f4\u63a5\u6297\u6c27\u5316\u4f5c\u7528 [4]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u95f4\u63a5\u6297\u6c27\u5316\uff1a<\/strong>NAC \u4f5c\u4e3a\u5408\u6210 GSH \u7684\u524d\u4f53\uff0c\u5728\u7ef4\u6301\u80ba\u7ec4\u7ec7\u4e2d\u8db3\u591f\u91cf\u7684\u8c37\u80f1\u7518\u80bd (GSH) \u542b\u91cf\uff0c\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u7ec6\u80de\u6bd2\u7d20\u635f\u5bb3\u65b9\u9762\u53d1\u6325\u95f4\u63a5\u6297\u6c27\u5316\u4f5c\u7528 [5]<\/sup>\u3002<\/span>\u3002NAC \u8fd8\u80fd\u901a\u8fc7\u6e05\u9664\u7ec6\u80de\u5185 ROS \u548c\u6291\u5236 MAPKs \u7684\u78f7\u9178\u5316\u800c\u5bf9\u80ba\u6ce1 2 \u578b\u4e0a\u76ae\u7ec6\u80de\u8d77\u4fdd\u62a4\u4f5c\u7528 [6]<\/sup>\uff1b\u4ee5\u53ca\u901a\u8fc7\u4e0b\u8c03\u9ad8\u6c27\u8bf1\u5bfc p38MAPK \u6d3b\u5316\u7684\u6297\u6c27\u5316\u673a\u5236\u4fdd\u62a4\u80ba\u7ec4\u7ec7[7]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/section>\n
2.2 \u6297\u708e\uff1a<\/strong><\/strong><\/strong>\u708e\u75c7\u98ce\u66b4\u4e2d\u7684\u6297\u708e\u52c7\u58eb<\/strong><\/strong><\/span><\/section>\n

<\/section>\n
\u6838\u56e0\u5b50\u041aB\uff08NF-\u041aB\uff09\u5bf9\u6c14\u9053\u708e\u75c7\u56e0\u5b50\u57fa\u56e0\u7684\u8f6c\u5f55\u8c03\u63a7\u8d77\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u6d3b\u5316\u7684 NF-\u041aB \u80fd\u4e0e\u9776\u57fa\u56e0\u542f\u52a8\u5b50\u548c\u589e\u5f3a\u5b50\u4e2d\u7684\u041aB \u5e8f\u5217\u7ed3\u5408\uff0c\u53c2\u4e0e\u4f17\u591a\u4e0e\u514d\u75ab\u548c\u708e\u75c7\u53cd\u5e94\u6709\u5173\u7684\u57fa\u56e0\u8f6c\u5f55\u8c03\u63a7\u3002NAC \u53ef\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u964d\u4f4e IL-8 \u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6291\u5236\u708e\u75c7\u53cd\u5e94\u3002\u53ef\u4ee5\u53bb\u9664\u6d3b\u6027\u6c27\u4ecb\u8d28\uff0c\u6709\u6548\u7684\u51cf\u5c11\u6d3b\u6027\u6c27\uff0c\u6291\u5236\u4f53\u5185\u6bd2\u7d20\u3001TNF-\u03b1\u7b49\u81f4\u7ec6\u80de\u6838\u56e0\u5b50 NF-\u03baB \u7684\u6d3b\u6027\uff0c\u4ece\u800c\u5207\u65ad NF-\u03baB \u4fe1\u53f7\u7684\u4f20\u8f93\u9014\u5f84\uff0c\u6700\u7ec8\u963b\u6b62 IL-8\u3001IL-6 \u7684\u4fe1\u606f\u8868\u8fbe\uff0c\u8fbe\u5230\u6291\u5236\u75be\u75c5\u591a\u53d1\u708e\u75c7\u7684\u76ee\u7684\uff0c\u4fdd\u62a4\u4f53\u5185\u7ec6\u80de <\/strong>[8-10]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u88ab\u75c5\u6bd2\u611f\u67d3\u7684\u5355\u6838\u7ec6\u80de\u4f1a\u5feb\u901f\u4ea7\u751f TNF-\u03b1\u3001IL-6\u3001IL-8 \u7b49\u4fc3\u708e\u56e0\u5b50\u53ca\u8d8b\u5316\u56e0\u5b50\uff0c\u4fc3\u8fdb\u5bbf\u4e3b\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u662f\u673a\u4f53\u6e05\u9664\u75c5\u6bd2\u6240\u5fc5\u9700\u7684\u3002\u4f46\u5927\u91cf\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u708e\u75c7\u4ecb\u8d28\u7684\u91ca\u653e\u6240\u4ea7\u751f\u7684\u300c\u708e\u75c7\u98ce\u66b4\u300d\u4f1a\u52a0\u91cd\u75c5\u60c5\u751a\u81f3\u9020\u6210\u81f4\u6b7b\u6027\u7684\u6c14\u9053\u3001\u80ba\u90e8\u53ca\u80ba\u5916\u810f\u5668\u7684\u635f\u4f24\u3002<\/strong>NF-\u041aB \u5728\u8bb8\u591a\u75c5\u6bd2\u7684\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u4ea6\u8d77\u8c03\u8282\u4f5c\u7528\uff0c\u75c5\u6bd2\u7684\u590d\u5236\u4f1a\u8fdb\u4e00\u6b65\u589e\u52a0\u7ec6\u80de\u5185 TNF-\u03b1\u7684\u4ea7\u751f\uff0c\u540e\u8005\u53c8\u4fc3\u8fdb\u81ea\u7531\u57fa\u7684\u4ea7\u751f\u548c\u6fc0\u6d3b NF-\u041aB\uff0c\u7531\u6b64\u8fdb\u5165\u75c5\u6bd2\u590d\u5236\u548c\u81ea\u7531\u57fa\u751f\u6210\u7684\u6076\u6027\u5faa\u73af\u3002\u8fd8\u539f\u6027\u7684\u5def\u57fa\u53ef\u76f4\u63a5\u5f71\u54cd\u8fd9\u4e00\u5faa\u73af\uff0c\u5728 GSH \u6c34\u5e73\u6216\u5def\u57fa\u6c34\u5e73\u5f88\u4f4e\u7684\u7ec6\u80de\u4e2d\uff0cTNF-\u03b1\u6240\u6fc0\u6d3b HIV \u7684\u6d3b\u6027\u662f\u589e\u5f3a\u7684\uff0c\u52a0\u5165 NAC \u53ef\u4ee5\u963b\u65ad NF-\u041aB \u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u963b\u65ad\u8fd9\u4e00\u5faa\u73af [11,12]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/section>\n
2.3 \u514d\u75ab\u8c03\u8282\uff1a<\/strong><\/strong><\/strong>\u514d\u75ab\u7a33\u6001\u7684\u8c03\u8282\u8005<\/strong><\/strong><\/span><\/section>\n

<\/section>\n
GSH \u7d0a\u4e71\u76f8\u5173\u7684\u514d\u75ab\u5e94\u7b54\u635f\u5bb3\u4e0e\u8840\u6d46\u548c CD4+T \u7ec6\u80de\u4e2d\u7684-SH \u6216 GSH \u6c34\u5e73\u7684\u4f4e\u4e0b\u6709\u5173\u3002<\/span>\u63d0\u9ad8\u6dcb\u5df4\u7ec6\u80de\u5185 GSH \u6c34\u5e73\uff0c\u964d\u4f4e\u81ea\u7531\u57fa\u751f\u6210\uff0c\u6709\u52a9\u4e8e\u6062\u590d CD4+\u7ec6\u80de\u7684\u529f\u80fd\u3002<\/span>NAC \u80fd\u591f\u901a\u8fc7\u6062\u590d\u7ec6\u80de\u5185-SH \u6c34\u5e73\u91cd\u5efa Th1\/Th2 \u7a33\u6001 <\/span><\/strong>[13]<\/sup>\u3002<\/span>NAC \u53ef\u6291\u5236\u80ba\u6ce1\u5de8\u566c\u7ec6\u80de\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u548c T \u6dcb\u5df4\u7ec6\u80de\u91ca\u653e TGF-\u03b2\u3001TNF-\u03b1\u3001IL-\uff18\u7b49\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\uff0c\u4ece\u800c\u963b\u6b62\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u805a\u96c6\uff0c\u4fdd\u62a4\u80ba\u7ec4\u7ec7\uff0c\u5728\u5de8\u566c\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\uff0cNAC \u53ef\u4ee5\u6291\u5236 TL4R \u4fe1\u53f7\u901a\u8def\u5f15\u8d77\u7684\u524d\u708e\u6027\u56e0\u5b50\u7684\u91ca\u653e\u3002\u6b64\u5916\uff0c\u5bf9\u793e\u533a\u83b7\u5f97\u6027\u80ba\u708e\uff08CAP\uff09\u60a3\u8005\uff0cNAC \u660e\u663e\u5347\u9ad8 CAP \u60a3\u8005\u5916\u5468\u8840\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u3001CD3\u3001CD4\/T \u7ec6\u80de\u6570\u3001CD4\/CD8 \u6bd4\u503c\u3002\u540c\u65f6\uff0cNAC \u4e5f\u4f7f\u5f97 CAP \u60a3\u8005\u8840 TNF-\u03b1\u6c34\u5e73\u964d\u4f4e\uff0cIL-2 \u6c34\u5e73\u5347\u9ad8 <\/strong>[14]<\/sup>\u3002<\/span><\/span><\/span><\/span><\/section>\n

<\/section>\n
2.4 <\/strong>\u964d\u4f4e\u6c14\u9053\u75c5\u539f\u83cc\u81f4\u75c5\u529b\uff1a<\/strong>\u907f\u514d\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u96ea\u4e0a\u52a0\u971c<\/strong><\/span><\/section>\n

<\/strong><\/span><\/section>\n

\"\u5fc5\u7136\u4e4b\u4e2d\u5bfb\u627e\u65b0\u7684\u7a81\u7834\u53e3\uff01\u4e00\u4f8b\u75ca\u6108\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5e26\u6765\u7684\u601d\u8003\"<\/p>\n

<\/span><\/section>\n
\u7ec6\u83cc\u7684\u5b9a\u690d\u662f\u6c14\u9053\u75be\u75c5\u8fdb\u5c55\u7684\u91cd\u8981\u56e0\u7d20\u3002\u6c14\u9053\u5185\u7ec6\u83cc\u8d1f\u8377\u7684\u589e\u52a0\u4ee5\u53ca\u79cd\u7c7b\u7684\u6539\u53d8\u4e0e\u547c\u5438\u9053\u708e\u75c7\u53ca FEV1 \u7684\u52a0\u901f\u4e0b\u964d\u6709\u5bc6\u5207\u5173\u7cfb <\/strong>[15]<\/sup>\u3002<\/span>NAC \u80fd\u964d\u4f4e\u6c14\u9053\u7ec6\u83cc\u8d1f\u8377<\/strong>[16]<\/sup>\u3002<\/span>\u7814\u7a76\u8fd8\u53d1\u73b0\uff0cNAC \u80fd\u591f\u964d\u4f4e\u6d41\u611f\u55dc\u8840\u6746\u83cc\u53ca\u80ba\u708e\u94fe\u7403\u83cc\u5728\u60a3\u8005\u6c14\u9053\u7684\u5b9a\u690d[17]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u7ec6\u83cc\u751f\u7269\u88ab\u819c\u5f62\u6210\u4e0e\u8bb8\u591a\u611f\u67d3\uff0c\u5305\u62ec\u547c\u5438\u673a\u76f8\u5173\u6027\u80ba\u708e\u3001\u652f\u6c14\u7ba1\u6269\u5f20\u3001\u652f\u6c14\u7ba1\u708e\u548c\u4e0a\u547c\u5438\u9053\u611f\u67d3\u5bc6\u5207\u76f8\u5173\u3002\u7814\u7a76\u53d1\u73b0\uff0cNAC \u53ef\u4ee5\u6291\u5236\u591a\u79cd\u7ec6\u83cc\u4ea7\u751f\u7684\u751f\u7269\u88ab\u819c\uff0c\u5982\u9769\u5170\u9633\u6027\u7403\u83cc\u4e2d\u7684\u8461\u8404\u7403\u83cc\u3001\u80ba\u708e\u94fe\u7403\u83cc\uff0c\u9769\u5170\u9634\u6027\u6746\u83cc\u4e2d\u7684\u94dc\u7eff\u5047\u5355\u80de\u83cc\u3001\u5927\u80a0\u57c3\u5e0c\u83cc\u3001\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u3001\u6d41\u611f\u55dc\u8840\u6746\u83cc\u7b49 [18,19]<\/sup>\u3002<\/span>\u5bf9\u4e8e\u5df2\u5f62\u6210\u7684\u751f\u7269\u88ab\u819c\uff0cNAC \u540c\u6837\u80fd\u7834\u574f\u7a7f\u900f\u5e76\u6740\u706d\u7ec6\u83cc [20]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
NAC \u5bf9\u80ba\u708e\u514b\u96f7\u4f2f\u6746\u83cc\u7684\u751f\u957f\u5177\u6709\u5f3a\u70c8\u7684\u6291\u5236\u4f5c\u7528\uff0c\u53ef\u589e\u52a0\u6c28\u82c4\u897f\u6797\u7684\u6297\u83cc\u6d3b\u6027\u3002NAC \u8054\u5408\u54cc\u62c9\u897f\u6797\u6216\u8005\u73af\u4e19\u6c99\u661f\u5bf9\u4e00\u4e9b\u94dc\u7eff\u5047\u5355\u80de\u83cc\u4ea7\u751f\u6291\u5236\u4f5c\u7528\u3002NAC \u6291\u83cc\u673a\u7406\u53ef\u80fd\u4e0e\u7ade\u4e89\u6027\u6291\u5236\u4e86\u7ec6\u83cc\u5bf9\u534a\u80f1\u6c28\u9178\u7684\u5229\u7528\u6709\u5173\u3002\u53e6\u5916\uff0cNAC \u4e2d\u7684-SH \u80fd\u4e0e\u7ec6\u83cc\u7ec6\u80de\u58c1\u4e0a\u7684\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u800c\u6291\u5236\u7ec6\u83cc\u751f\u957f <\/span>[21]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u540c\u6837\uff0c\u5bf9\u4e8e\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\uff0cNAC \u53ef\u901a\u8fc7\u51cf\u4f4e\u7ec6\u80de\u5185 H2<\/sub>O2<\/sub>\u6d53\u5ea6\uff0c\u91cd\u5efa\u7ec6\u80de\u5185-SH \u6c34\u5e73\u6765\u6062\u590d\u7ec6\u80de\u5185\u5e73\u8861\uff0c\u4f7f\u547c\u5438\u9053\u6d41\u611f\u75c5\u6bd2\u548c\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u6ef4\u5ea6\u4e0b\u964d\uff0c\u5e76\u6291\u5236\u75c5\u6bd2\u590d\u5236 <\/span>[22]<\/sup>\u3002<\/span>NAC \u5bf9\u91cd\u75c7\u6d41\u611f\u60a3\u8005\u5177\u6709\u660e\u663e\u7684\u6cbb\u7597\u6548\u679c\u3002\u7814\u7a76\u8bc1\u5b9e\uff0cNAC \u5bf9\u6d41\u611f\u75c5\u6bd2 N1 H1 \u7684\u795e\u7ecf\u6c28\u9178\u9176\u6d3b\u6027\u5177\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5bf9\u6d41\u611f\u75c5\u6bd2 N1 H1 \u7684\u75c5\u6bd2\u4f53\u7ed3\u6784\u4e5f\u6709\u660e\u663e\u7684\u7834\u574f\u4f5c\u7528 <\/span>[23]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u6b64\u5916\uff0cHIV \u611f\u67d3\u8005\u53ca\u4e25\u91cd\u514d\u75ab\u529f\u80fd\u7f3a\u9677\u8005\u77ed\u671f\u9ad8\u5242\u91cf\u4f7f\u7528 NAC\uff0c\u53ef\u83b7\u5f97\u514d\u75ab\u5b66\u548c\u75c5\u6bd2\u5b66\u4e0a\u7684\u6cbb\u7597\u6548\u679c <\/span>[24]<\/sup>\uff0c<\/span>\u5176\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u4e0e NAC \u6062\u590d\u6dcb\u5df4\u7ec6\u80de\u5185 GSH \u6c34\u5e73\uff0c\u964d\u4f4e\u81ea\u7531\u57fa\u751f\u6210\u4ece\u800c\u6062\u590d CD4+\u7ec6\u80de\u7684\u529f\u80fd\u6709\u5173\u3002\u4e5f\u6709\u7814\u7a76\u663e\u793a\uff0c\u5bf9 AIDS \u60a3\u8005\u795e\u7ecf\u7cfb\u7edf\u7684\u75c5\u53d8\uff0cNAC \u53ef\u901a\u8fc7\u6062\u590d\u7ec6\u80de\u5185 GSH \u7684\u6c34\u5e73\uff0c\u963b\u65ad\u7ebf\u7c92\u4f53\u7684\u5206\u89e3\uff0c\u8fbe\u5230\u51cf\u7f13 AIDS \u8fdb\u5c55\u4f5c\u7528 <\/span>[25]<\/sup>\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\u63a2\u7d22\u4e0d\u6b62\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5728\u65b0\u51a0\u80ba\u708e\u4e2d\u6216\u53ef\u518d\u521b\u7a81\u7834<\/strong><\/span><\/section>\n

<\/section>\n
\u8fd1\u671f\u56fd\u5185\u5916\u62a5\u9053\uff0c\u6cbb\u7597 SARS \u7684\u8fc7\u7a0b\u4e2d\uff0cNAC \u5bf9\u80ba\u90e8\u7684\u5065\u5eb7\u8d77\u5230\u79ef\u6781\u7684\u91cd\u8981\u4f5c\u7528 <\/span>[26]<\/sup>\uff0c\u80fd\u591f\u52a0\u5feb SARS \u5f71\u50cf\u7684\u5438\u6536 <\/span>[27]<\/sup>\u3002<\/span>\u57fa\u4e8e\u65b0\u51a0\u75c5\u6bd2\u548c SARS \u7684\u76f8\u4f3c\u6027\uff0c\u90a3\u4e48\uff0cNAC \u662f\u5426\u6709\u53ef\u80fd\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u6cbb\u7597\u5e26\u6765\u79ef\u6781\u7684\u4f5c\u7528\uff1f\u4e0d\u59a8\u5148\u4ece\u836f\u7406\u5b66\u4e0a\u770b\u770b\uff0cNAC \u7a76\u7adf\u662f\u6f5c\u529b\u80a1\u4ea6\u6216\u53ea\u662f\u6d77\u5e02\u8703\u697c\uff1f<\/span><\/section>\n

<\/span><\/section>\n
\u7406\u8bba\u4e0a\u7684\u652f\u6301\u4f9d\u636e\uff1a<\/span><\/section>\n

<\/span><\/section>\n
1\u3001\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5c38\u4f53\u89e3\u5256\u663e\u793a\uff0c\u80ba\u90e8\u9664\u4e86\u708e\u75c7\u4e4b\u5916\uff0c\u8fd8\u6709\u5927\u91cf\u7684\u9ad8\u7c98\u6027\u7684\u7c98\u6db2\uff0c\u8fd9\u5c06\u5bfc\u81f4\u75c5\u4eba\u7684\u901a\u6c14\u4e0d\u901a\u987a\u3002\u4f5c\u4e3a\u4e00\u6b3e\u7ecf\u5178\u7684\u795b\u75f0\u836f\uff0cNAC \u5206\u5b50\u4e2d\u7684-SH \u57fa\u56e2\u80fd\u76f4\u63a5\u4f5c\u7528\u4e8e\u75f0\u6db2\u4e2d\u7cd6\u86cb\u767d\u591a\u80bd\u94fe\u7684\u4e8c\u786b\u952e\uff08-S-S)\uff0c\u4f7f\u4e4b\u65ad\u88c2\uff0c\u7834\u574f\u75f0\u6db2\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u9ecf\u75f0\u6db2\u5316\uff0c\u964d\u4f4e\u75f0\u6db2\u9ecf\u7a20\u5ea6\uff0c\u4fc3\u8fdb\u75f0\u6db2\u6392\u51fa\u3002\u7d27\u6025\u65f6\u8fd8\u53ef\u4ee5\u6c14\u7ba1\u5185\u6ef4\u5165\uff0c\u4f7f\u75f0\u8fc5\u901f\u53d8\u7a00\uff0c\u4fbf\u4e8e\u5438\u5f15\u6392\u75f0\u3002\u540c\u65f6\uff0cNAC \u5bf9\u8131\u6c27\u6838\u7cd6\u6838\u9178\u4e5f\u6709\u88c2\u89e3\u4f5c\u7528\uff0c\u4ece\u800c\u964d\u4f4e\u75f0\u7684\u9ecf\u6ede\u6027\uff0c\u4f7f\u75f0\u6613\u54b3\u51fa\u3002\u6b64\u5916\uff0cNAC \u53ef\u4ee5\u663e\u8457\u589e\u52a0\u9ecf\u6db2\u7ea4\u6bdb\u8f6c\u8fd0\uff0c\u4fc3\u8fdb\u75f0\u6db2\u6e05\u9664\u3002<\/span><\/section>\n

<\/span><\/section>\n
2\u3001\u901a\u8fc7\u8c03\u8282\u7ec6\u80de\u5185\u591a\u79cd\u4fe1\u53f7\u901a\u8def\u5e72\u6270\u75c5\u6bd2\u7684\u589e\u6b96\u3002\u75c5\u6bd2\u662f\u4e00\u79cd\u975e\u7ec6\u80de\u578b\u5fae\u751f\u7269\uff0c\u8fdb\u5165\u7ec6\u80de\u540e\u5fc5\u987b\u5229\u7528\u6216\u300c\u7ed1\u67b6\u300d\u7ec6\u80de\u7684\u539f\u6709\u7ec6\u80de\u4f20\u5bfc\u901a\u8def\u7684\u548c\u4ee3\u8c22\u7cfb\u7edf\u4e3a\u75c5\u6bd2\u589e\u6b96\u670d\u52a1\u3002NAC \u53ef\u901a\u8fc7\u8c03\u8282 NF-\u041aB \u7ec6\u80de\u901a\u8def\uff0c\u6291\u5236\u7ec6\u80de\u7684\u51cb\u4ea1\u3002<\/strong>\u5728\u75c5\u6bd2\u7684\u589e\u503c\u4e2d\u53d1\u6325\u5176\u5e94\u6709\u7684\u4f5c\u7528\u3002<\/strong><\/span><\/section>\n

<\/strong><\/span><\/section>\n
3\u3001\u901a\u8fc7\u8c03\u8282\u673a\u4f53\u7684\u514d\u75ab\u529f\u80fd\u800c\u53d1\u6325\u6297\u75c5\u6bd2\u4f5c\u7528\u3002\u75c5\u6bd2\u611f\u67d3\u673a\u4f53\u540e\uff0c\u4f1a\u4ea7\u751f\u5f02\u5e38\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u4ea7\u751f\u5931\u63a7\u6027\u5168\u8eab\u708e\u75c7\u53cd\u5e94\uff0c\u7279\u522b\u662f\u300c\u708e\u75c7\u98ce\u66b4\u300d\u5bfc\u81f4\u7684\u673a\u4f53\u635f\u4f24\u3002NAC \u53ef\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u548c\u708e\u75c7\u4ecb\u8d28\u4ece\u800c\u963b\u6b62\/\u6216\u51cf\u5f31\u75c5\u4eba\u4f53\u5185\u300c\u708e\u75c7\u98ce\u66b4\u300d\u3002<\/strong><\/span><\/section>\n

<\/strong><\/span><\/section>\n
4\u3001\u5f71\u54cd S \u86cb\u767d\u4e0e\u53d7\u4f53\u5728\u7a7a\u95f4\u6784\u8c61\u4e0a\u300c\u5951\u5408\u300d\u3002S \u86cb\u767d\u662f\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u5173\u952e\u86cb\u767d\u3002S \u86cb\u767d\u5728\u5bbf\u4e3b\u7ec6\u80de\u5185\u7ffb\u8bd1\u540e\u53ef\u88c2\u89e3\u4e3a S1 \u548c S2 \u4e24\u4e2a\u4e9a\u5355\u4f4d\uff0cS1 \u62c5\u8d1f\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u7ed3\u5408\uff0cS2 \u4ecb\u5bfc\u75c5\u6bd2-\u7ec6\u80de\u878d\u5408\u3002\u88c2\u89e3\u540e\u7684 S1 \u548c S2 \u4e4b\u95f4\u7531-S-S \u952e\u8fde\u63a5\u5e76\u5f62\u6210\u7a33\u5b9a\u7684\u7ed3\u6784\u3002\u800c NAC \u5206\u5b50\u4e2d\u6240\u542b\u7684-SH \u53ef\u4e0e\u86cb\u767d\u4e2d\u7684-S-S \u952e\u7ed3\u5408\uff0c\u4f7f\u86cb\u767d\u88c2\u89e3\u3002\u8bbe\u60f3\uff0cNAC \u662f\u5426\u6709\u53ef\u80fd\u9488\u5bf9 S \u86cb\u767d\u7684\u88c2\u89e3\uff0c\u5f71\u54cd S \u86cb\u767d\u4e0e\u53d7\u4f53\u5728\u7a7a\u95f4\u6784\u8c61\u4e0a\u300c\u5951\u5408\u300d\uff0c\u8fbe\u5230\u963b\u6b62\u75c5\u6bd2\u5165\u4fb5\u5bbf\u4e3b\u7ec6\u80de\u7684\u76ee\u7684\uff0c\u503c\u5f97\u6df1\u5165\u63a2\u8ba8\u3002<\/strong><\/span><\/section>\n

<\/strong><\/span><\/section>\n
\u7efc\u4e0a\u6240\u8ff0\uff0c\u5c3d\u7ba1 NAC \u662f\u4e00\u79cd\u300c\u8001\u300d\u836f\uff0c\u4f46\u5b83\u4e00\u76f4\u662f\u547c\u5438\u9886\u57df\u7814\u7a76\u7684\u70ed\u70b9\u3002\u4e0e\u5176\u5b83\u7c7b\u795b\u75f0\u836f\u5982\u6c28\u6eb4\u7d22\u3001\u6eb4\u5df1\u65b0\u76f8\u6bd4\uff0c\u867d\u7136\u5728\u795b\u75f0\u4f5c\u7528\u4e0a\u5177\u6709\u76f8\u4f3c\u6027\uff0c\u4f46\u662f\uff0c\u5bf9\u4e8e\u75f0\u6db2\u7279\u522b\u9ecf\u7a20\u7684\u60a3\u8005\uff08\u4f8b\u5982\u5e76\u53d1\u611f\u67d3\uff0c\u5916\u79d1\u56f4\u624b\u672f\u671f\/ICU \u60a3\u8005\uff09NAC \u53ef\u80fd\u66f4\u5177\u6709\u4f18\u52bf\u3002NAC \u9664\u80fd\u4ee5\u88c2\u89e3\u75f0\u6db2\u3001\u4fc3\u8fdb\u7ea4\u6bdb\u6446\u52a8\u7684\u65b9\u5f0f\u795b\u75f0\u4ee5\u5916\uff0c\u8fd8\u5177\u6709\u6297\u6c27\u5316\u3001\u6297\u708e\u3001\u964d\u4f4e\u6c14\u9053\u75c5\u539f\u83cc\u81f4\u75c5\u529b\u53ca\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u3002\u76f8\u4fe1\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0cNAC \u6cbb\u7597\u6025\u3001\u6162\u6027\u547c\u5438\u9053\u75be\u75c5\uff0c\u4e43\u81f3\u75c5\u6bd2\u5f15\u8d77\u7684\u80ba\u90e8\u75c5\u53d8\u7684\u6f5c\u80fd\u53ef\u671b\u4e0d\u65ad\u5730\u88ab\u6fc0\u53d1\uff0c\u4e3a\u6297\u51fb\u300c\u65b0\u51a0\u80ba\u708e\u300d\u8c31\u5199\u65b0\u7bc7\u7ae0\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
\u672c\u6587\u4f5c\u8005\uff1a\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662 \u5d14\u6c38\u8000 \u6559\u6388<\/span><\/section>\n
\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u836f\u7406\u5b66\u6559\u7814\u5ba4  \u6559\u6388\uff0c\u535a\u58eb\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\u3002<\/span><\/section>\n
\u5148\u540e\u83b7\u5f97 2014 \u5e74\u5ea6\u5b9d\u94a2 \u300c\u6559\u80b2\u5956\u300d \uff0c2015 \u5e74\u4e0a\u6d77\u533b\u5b66\u79d1\u6280\u5956\u300c\u4e8c\u7b49\u5956\u300d\uff0c2017 \u5e74\u4e2d\u534e\u533b\u5b66\u5956\u300c\u4e8c\u7b49\u5956\u300d \u3002<\/span><\/section>\n
\u4e3b\u8981\u7814\u7a76\u65b9\u5411\uff1a\u54ee\u5598\u53ca\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u65b0\u9776\u70b9\u548c\u65b0\u836f\u7684\u8f6c\u5316\u836f\u7406\u5b66\u7814\u7a76\u3002<\/span><\/section>\n
\u4f5c\u4e3a\u9879\u76ee\u4e3b\u6301\u4eba\u5148\u540e\u4e3b\u6301\u56fd\u5bb6\u300c\u65b0\u836f\u521b\u5236\u300d\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff1b\u4e3b\u6301\u591a\u9879\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9762\u4e0a\u9879\u76ee\u53ca\u4e3b\u6301\u4e0a\u6d77\u5e02\u7ea7\u91cd\u70b9\u9879\u76ee \u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
\u8d23\u7f16\uff1aKendy<\/span><\/section>\n

<\/section>\n
\u6b22\u8fce\u5411\u62a5\u6599\uff01<\/span><\/em><\/span>\u8bf7\u52a0\u5fae\u4fe1\uff1a<\/span><\/em>dxylzzb<\/span><\/em><\/span><\/section>\n
\"\u5fc5\u7136\u4e4b\u4e2d\u5bfb\u627e\u65b0\u7684\u7a81\u7834\u53e3\uff01\u4e00\u4f8b\u75ca\u6108\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5e26\u6765\u7684\u601d\u8003\"<\/section>\n

<\/section>\n
\u9898\u56fe\u6765\u6e90\uff1a\u7ad9\u9177\u6d77\u6d1b<\/span><\/section>\n
\u53c2\u8003\u6587\u732e\uff1a<\/span><\/section>\n
1. Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why[J]. Free Radic Res, 2018, 52(7): 751 – 762.<\/span><\/section>\n
2. Prescott LF. New approaches in managing drug overdosage and poisoning[J]. British Medical Journal, 1983, 287(6387): 274 – 276.<\/span><\/section>\n
3. Repine JE, Bast A, Lankhorst I. Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group[J]. Am J Respir Crit Care Med, 1997, 156(1): 341 – 357.<\/span><\/section>\n
4. Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why[J]. Free Radic Res, 2018, 52(7): 751 – 762.<\/span><\/section>\n
5. Kelly GS. Clinical applications of N-acetylcysteine[J]. Altern Med Rev, 1998, 3(2): 114 – 27.<\/span><\/section>\n
6. \u7b26\u8dc3\u5f3a, \u5362\u4ef2\u6bc5, \u65b9\u82b3, \u7b49. \u6c27\u5316\u5e94\u6fc0\u5bf9\u80ba\u6ce1\u2161\u578b\u4e0a\u76ae\u7ec6\u80de MAPKs \u7684\u6fc0\u6d3b\u53ca N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u5e72\u9884\u4f5c\u7528 [J]. \u7b2c\u4e09\u519b\u533b\u5927\u5b66\u5b66\u62a5, 2008, 30: 820 – 822.<\/span><\/section>\n
7. \u8c2d\u5229\u5e73, \u8bb8\u5cf0, \u5321\u51e4\u68a7. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u9ad8\u6c27\u80ba\u635f\u4f24\u4fdd\u62a4\u673a\u5236\u4e0e p38 \u4e1d\u88c2\u7d20\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\u9014\u5f84\u7684\u76f8\u5173\u6027\u7814\u7a76 [J]. \u4e2d\u56fd\u5371\u91cd\u75c5\u6025\u6551\u533b\u5b66, 2010, 22(8): 469 – 472<\/span><\/section>\n
8. \u83ab\u7ea2\u7f28, \u949f\u5357\u5c71, \u90d1\u52b2\u5e73, \u7b49. \u6838\u56e0\u5b50-\u03baB \u5728\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u7684\u6fc0\u6d3b\u53ca N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u5f71\u54cd [J]. \u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u4e0e\u6cbb\u7597\u5b66, 2000: 193 – 196.<\/span><\/section>\n
9. Oka S, Kamata H,Kamata K\uff0cet al. N-Acetylcysteine suppresses TNF-induced NF-\u03baB activation through inhibition of I\u03baB kinases. FEBS Lett\uff0c2000,472(2 – 3):196 – 202.<\/span><\/section>\n
10. Paranjpe A, Cacalano NA, Hume WR, et al. N-Acetyl Cysteine Mediates Protection from 2-Hydroxyethyl Methacrylate Induced Apoptosis via Nuclear Factor Kappa B\u2013Dependent and Independent Pathways: Potential Involvement of JNK. Toxicol Sci,2009,108(2):356 – 366.<\/span><\/section>\n
11. Geiler J, Michaelis M, Naczk P, et al. N-acetyl-L-cysteine(NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A vurus. Biochem Pharmacol, 2010,79(3):413 – 420.<\/span><\/section>\n
12.  Mata M, Moreillo E, Gimeno C, et al. N-acetyl-L-cysteine(NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus(RSV). Biochem Pharmacol, 2011,82(5):548 – 555.<\/span><\/section>\n
13.  Monick MM, Samavati L, Butler NS, et al. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production[J]. J Immunol, 2003, 171(10): 5107 – 15.<\/span><\/section>\n
14. \u738b\u5fd7\u52c7, \u738b\u7231\u4e2d. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u8001\u5e74\u80ba\u708e\u60a3\u8005\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528 [J]. \u5185\u79d1\u6025\u5371\u91cd\u75c7\u6742\u5fd7, 2013, 19(3): 157 – 159.<\/span><\/section>\n
15. Wilkinson TM, Patel IS, Wilks M, et al. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2003, 167(8): 1090 – 5.<\/span><\/section>\n
16. Riise GC, Larsson S, Larsson P, et al. The intrabronchial microbial flora in chronic bronchitis patients: a target for N-acetylcysteine therapy?[J]. Eur Respir J, 1994, 7(1): 94 – 101.<\/span><\/section>\n
17. Messier EM, Day BJ, Bahmed K, et al. N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner[J]. Am J Respir Mol Biol, 2013, 48(5): 559 – 67.<\/span><\/section>\n
18. \u8d75\u94c1\u6885, \u5218\u53c8\u5b81. N-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u7684\u6297\u83cc\u6d3b\u6027\u53ca\u5bf9\u7ec6\u83cc\u751f\u7269\u88ab\u819c\u7684\u6291\u5236\u4f5c\u7528 [J]\u3002\u56fd\u9645\u547c\u5438\u6742\u5fd7, 2009, 29(13): 809 – 811.<\/span><\/section>\n
19. Blasi F, Page C, Rossolini GM, et al. The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections[J]. Respir Med, 2016, 117: 190 – 7.<\/span><\/section>\n
20. Mansouri MD, Darouiche RO. In vitro antimicrobial activity of N-acetylcysteine against bacteria colonising central venous catheters[J]. Int J Antimicrob Agents, 2007, 29(4): 474 – 6.<\/span><\/section>\n
21. Parry MF, Neu HC. Effect of N-acetylcysteine on antibiotic activity and bacterial growth in vitro[J]. Journal of Clinical Microbiology, 1977, 5(1): 58 – 61.<\/span><\/section>\n
22. Manuel M, Esteban M, Concepcion G, et al. N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)[J]. Biochemical Pharmacology, 2011, 82(5): 548 – 555.<\/span><\/section>\n
23. \u6797\u96e8\u99a8, \u738b\u5146\u96ea\uff0c\u6768\u5586\u4e1c\u7b49\uff0cN-\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9\u6d41\u611f\u75c5\u6bd2 N1 H1 \u7684\u6291\u5236\u4f5c\u7528 [J]\u3002\u4e2d\u56fd\u5fae\u751f\u6001\u5b66\u6742\u5fd7\uff0c 2014\uff0c26(2): 887 – 889.<\/span><\/section>\n
24. Muller F, Svardal AM Nordoy I et al. Virological and immtmological effect of antioxidant treatment in patients with HIV infection\uff0eEur J Clin Invest, 2000. 30(10):905\u3002<\/span><\/section>\n
25. Sung JH, Shin SA, Park HK, et a1. Protective effect of glutathionein HIV-l lytic peptide l-induced cell death in human neuronal cells. J Neurovirol, 2001, 7(5):454.<\/span><\/section>\n
26.  Severe Acute Respiratory Sydrome(SARS). By NutritonReview.org – April 26, 2013.<\/span><\/section>\n
27.  \u91d1\u8fdc\u6797\uff0c\u6210\u4ef2\uff0c\u4e25\u5fd7\u521a\u7b49\uff0c\u4e59\u9170\u534a\u80f1\u6c28\u9178\u5bf9 SARS \u80ba\u90e8\u5f71\u50cf\u5438\u6536\u7f13\u6162\u7684\u6cbb\u7597\u4f5c\u7528 [J]\u3002\u4e2d\u534e\u5b9e\u7528\u533b\u5b66\u30022005,7\uff084\uff09\uff1a78 – 78.<\/span><\/section>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u75ca\u6108\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7684\u7528\u836f\u4e4b\u4e00\uff1a\u6309\u7167\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u56db\u7248\uff09\u300b\uff0c\u56db\u5ddd\u9996\u4f8b\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u60a3\u8005 […]<\/p>\n","protected":false},"author":1,"featured_media":134083,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/134082"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=134082"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/134082\/revisions"}],"predecessor-version":[{"id":134087,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/134082\/revisions\/134087"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/134083"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=134082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=134082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=134082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}