{"id":134636,"date":"2020-03-03T13:00:50","date_gmt":"2020-04-21T03:34:17","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/134636\/"},"modified":"2020-04-21T11:34:21","modified_gmt":"2020-04-21T03:34:21","slug":"6367ab3901","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/134636\/","title":{"rendered":"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c"},"content":{"rendered":"
\n

<\/section>\n

\u672c\u6587\u4f5c\u8005\uff1a\u6d78\u6708<\/span><\/p>\n


<\/span><\/p>\n

\u4e0d\u540c\u7684\u4f20\u67d3\u75c5\u7531\u4e0d\u540c\u7684\u75c5\u539f\u751f\u7269\u5f15\u8d77\uff0c\u800c<\/span>\u660e\u786e\u75c5\u539f\u4f53\u4f20\u64ad\u7684\u81ea\u7136\u5bbf\u4e3b\u548c\u4e2d\u95f4\u5bbf\u4e3b\u5bf9\u5207\u65ad\u52a8\u7269\u4f20\u67d3\u6e90\uff0c\u51cf\u5c11\u75be\u75c5\u4f20\u64ad\u6709\u91cd\u8981\u610f\u4e49\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u76ee\u524d\uff0c\u5927\u591a\u6570\u7814\u7a76\u5c06\u65b0\u51a0\u75c5\u6bd2\u7684\u300c\u81ea\u7136\u5bbf\u4e3b\u300d\u548c\u300c\u4e2d\u95f4\u5bbf\u4e3b\u300d\u6307\u5411\u4e24\u79cd\u5e38\u89c1\u7684\u91ce\u751f\u52a8\u7269\u2014\u2014\u8759\u8760\uff0c\u7a7f\u5c71\u7532\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6700\u65e9\u88ab\u5173\u6ce8\u7684\u662f\u8759\u8760\uff0c\u5b83\u662f\u547c\u58f0\u6700\u9ad8\u7684<\/span>\u65b0\u51a0\u75c5\u6bd2\u6f5c\u5728\u81ea\u7136\u5bbf\u4e3b\u3002<\/span><\/p>\n


<\/span><\/p>\n

1 \u6708 23 \u65e5\uff0c\u77f3\u6b63\u4e3d\u56e2\u961f\u5728\u9884\u5370\u672c\u5e73\u53f0 bioRxiv<\/em> \u53d1\u8868\u7814\u7a76\u6307\u51fa\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e0e SARS \u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u4e00\u81f4\u6027\u4e3a 79.5%\uff1b\u4e0e\u6b64\u524d\u5728\u4e91\u5357\u4e2d\u83ca\u5934\u8760\u4e0a\u68c0\u6d4b\u5230\u7684\u8759\u8760\u51a0\u72b6\u75c5\u6bd2  RaTG13 \u57fa\u56e0\u5e8f\u5217\u4e00\u81f4\u6027\u4e3a 96.2%\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5f53\u65f6\u8bb8\u591a\u4eba\u8ba4\u4e3a\uff0c\u65b0\u51a0\u75c5\u6bd2\u7531\u8759\u8760\u5e26\u5165\u4eba\u7c7b\u793e\u4f1a\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

bioRxiv<\/span> \u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/p>\n

\u4f46\u8fd9\u9879\u7814\u7a76\u540c\u65f6\u53d1\u73b0\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e0e RaTG13 \u7684\u53d7\u4f53 S \u86cb\u767d<\/span>\u5e8f\u5217\u4e00\u81f4\u6027\u4ec5\u6709 93.1%\uff0c\u5dee\u5f02\u8f83\u5927\uff0c\u4e24\u8005\u76f8\u8ddd 1100 \u4e2a\u6838\u82f7\u9178\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u540c\u65f6\uff0c\u6839\u636e 1 \u6708 30 \u65e5\u300a\u67f3\u53f6\u5200\u300b\u8bba\u6587\u7684\u4e00\u4e9b\u7ec6\u8282\uff0c9 \u540d\u786e\u8bca\u60a3\u8005\u4e2d\u6709 8 \u4eba\u66fe\u53bb\u8fc7\u534e\u5357\u6d77\u9c9c\u5e02\u573a\uff0c\u4f46\u5f53\u65f6\u5e02\u573a\u5185\u5e76\u672a\u51fa\u552e\u4efb\u4f55\u8759\u8760\uff1b\u6b64\u5916\uff0c\u9996\u6b21\u75c5\u4f8b\u51fa\u73b0\u65f6\u95f4\u4e3a 12 \u6708\uff0c\u6b63\u597d\u662f\u8759\u8760\u7684\u51ac\u7720\u671f\uff0c\u7531\u8759\u8760\u76f4\u63a5\u611f\u67d3\u4eba\u7c7b\u7684\u53ef\u80fd\u6027\u4e0d\u5927\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8fd9\u610f\u5473\u7740\uff0c\u65b0\u51a0\u75c5\u6bd2\u81ea\u7136\u5bbf\u4e3b\u5f88\u6709\u53ef\u80fd\u662f\u8759\u8760\uff0c<\/span>\u4f46\u4ece\u8759\u8760\u5230\u4eba\u7c7b\u4e4b\u95f4\u4ecd\u7136\u53ef\u80fd\u5b58\u5728 1 \u4e2a\u6216\u591a\u4e2a\u4e2d\u95f4\u5bbf\u4e3b\u5c06\u75c5\u6bd2\u300c\u8f6c\u624b\u300d\u3002<\/span><\/span><\/strong><\/span>\u5c31\u50cf 2003 \u5e74\u7684 SARS \u75c5\u6bd2\uff0c\u5b83\u7531\u81ea\u7136\u5bbf\u4e3b\u8759\u8760\u4f20\u67d3\u7ed9\u679c\u5b50\u72f8\uff0c\u518d\u7531\u679c\u5b50\u72f8\u4f20\u67d3\u7ed9\u4eba\u7c7b\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8759\u8760\u4e4b\u540e\uff0c\u4eba\u4eec\u5f00\u59cb\u5bfb\u627e\u75c5\u6bd2\u7684\u4e2d\u95f4\u5bbf\u4e3b\u3002<\/span><\/p>\n


<\/span><\/p>\n


<\/span><\/p>\n

\u7a7f\u5c71\u7532\u5982\u4f55\u6210\u4e3a\u5173\u6ce8\u7126\u70b9\uff1f
<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u4e0e\u8759\u8760\u88ab\u65e9\u65e9\u9501\u5b9a\u4e0d\u540c\uff0c\u5728\u7a7f\u5c71\u7532\u4e4b\u524d\uff0c\u86c7\u4e5f\u66fe\u53d7\u5230\u5173\u6ce8\u3002<\/span><\/p>\n


<\/p>\n

1 \u6708 22 \u65e5\uff0c\u5317\u4eac\u5927\u5b66\u3001\u5e7f\u897f\u4e2d\u533b\u836f\u5927\u5b66\u3001\u5b81\u6ce2\u5927\u5b66\u548c\u6b66\u6c49\u751f\u7269\u5de5\u7a0b\u5b66\u9662\u8054\u5408\u7814\u7a76\u56e2\u961f\u5728 Journal of Medical Virology <\/em>\u53d1\u8868\u7814\u7a76\u6307\u51fa\uff0c\u65e9\u671f\u65b0\u51a0\u60a3\u8005\u66fe\u53bb\u8fc7\u534e\u5357\u6d77\u9c9c\u5e02\u573a\uff0c\u5e02\u573a\u5185\u66fe\u8d29\u5356\u86c7\u3001\u5bb6\u79bd\u7b49\u7269\u79cd\uff0c\u56e0\u6b64\u7814\u7a76\u8005\u5bf9\u8fd9\u4e9b\u7269\u79cd\u57fa\u56e0\u5e8f\u5217\u8fdb\u884c\u5206\u6790\u540e\u53d1\u73b0\uff0c\u65b0\u51a0\u75c5\u6bd2\u5bc6\u7801\u5b50\u4e0e\u86c7\u7684\u5bc6\u7801\u5b50\u6709\u8f83\u9ad8\u7684\u76f8\u4f3c\u6027\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

Journal of Medical Virology<\/span><\/em> \u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/p>\n

\u5f88\u5feb<\/span>\u6709\u5b66\u8005\u6307\u51fa\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\u8759\u8760\u4e0e\u65b0\u51a0\u75c5\u6bd2\u7684\u5bc6\u7801\u5b50\u76f8\u4f3c\u5ea6\u624d\u662f\u6700\u9ad8\u7684\uff0c\u7814\u7a76\u7ed3\u8bba\u5374\u4fa7\u91cd\u4e8e\u86c7\uff0c\u7ed3\u8bba\u53ef\u4fe1\u5ea6\u4e0d\u9ad8\u3002\u82cf\u683c\u5170\u683c\u62c9\u65af\u54e5\u5927\u5b66\u75c5\u6bd2\u5b66\u5bb6 David Robertson \u8868\u793a\uff1a\u76ee\u524d\u7684\u8bc1\u636e\u503e\u5411\u4e8e\u8ba4\u4e3a\u65b0\u51a0\u75c5\u6bd2\u5728\u54fa\u4e73\u52a8\u7269\u4e2d\u4f20\u64ad\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u86c7\u7684\u7ed3\u8bba\u53d7\u5230\u5e7f\u6cdb\u8d28\u7591\uff0c\u4e0e\u6b64\u540c\u65f6\uff0c2019 \u5e74\u7684\u4e00\u9879\u7814\u7a76\u91cd\u65b0\u8fdb\u5165\u89c6\u91ce\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

Viruses<\/span><\/em> \u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/p>\n

2019 \u5e74 3 \u6708\uff0c\u5e7f\u4e1c\u6d77\u5173\u66fe\u622a\u83b7 21 \u53ea\u8d70\u79c1\u7684\u7a7f\u5c71\u7532\u3002\u8fd9\u4e9b\u7a7f\u5c71\u7532\u5065\u5eb7\u72b6\u51b5\u4e0d\u4f73\uff0c\u7ecf\u6551\u6cbb\u540e\u4ecd\u6709 16 \u53ea\u6b7b\u4ea1\uff0c\u51fa\u73b0\u80ba\u90e8\u80bf\u80c0\uff0c\u80ba\u5185\u6709\u6ce1\u6cab\u72b6\u6db2\u4f53\uff0c\u6709\u80ba\u7ea4\u7ef4\u5316\u7b49\u75c7\u72b6\uff0c\u5c11\u6570\u6b7b\u4ea1\u7a7f\u5c71\u7532\u8fd8\u6709\u809d\u813e\u80bf\u5927\u3002<\/span><\/p>\n


<\/p>\n

V<\/em>iruses<\/em> \u4e8e 2019 \u5e74 10 \u6708\u53d1\u5e03\u7684\u4e00\u7bc7\u8bba\u6587\u5bf9\u8fd9 21 \u53ea\u7a7f\u5c71\u7532\u8fdb\u884c\u4e86\u57fa\u56e0\u5b66\u7814\u7a76\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e9b\u7a7f\u5c71\u7532\u8eab\u4e0a\u7684\u75c5\u6bd2\u4ee5\u4ed9\u53f0\u75c5\u6bd2\u548c\u51a0\u72b6\u75c5\u6bd2\u4e3a\u4e3b\u3002<\/span>\u6709 2 \u53ea\u7a7f\u5c71\u7532\u8eab\u4e0a\u53d1\u73b0\u4e86\u79cd\u7c7b\u4e30\u5bcc\u7684\u51a0\u72b6\u75c5\u6bd2\uff0c\u5176\u4e2d SARS \u75c5\u6bd2\u6700\u591a\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

Viruses<\/span><\/em> \u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/p>\n

\u5bf9\u8fd9\u4e9b\u51a0\u72b6\u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u68c0\u6d4b\u6d4b\u8fc7\u663e\u793a\uff0c\u8fd9\u4e9b\u75c5\u6bd2\u4e0e\u8759\u8760\u4e2d\u7684 SARS \u75c5\u6bd2\u5177\u6709 80% \u4ee5\u4e0a\u7684\u76f8\u4f3c\u6027\u2014\u2014\u51a0\u72b6\u75c5\u6bd2\uff0c\u7a7f\u5c71\u7532\uff0c\u8759\u8760\u5c31\u8fd9\u6837\u88ab\u8fde\u6210\u4e86\u4e00\u6761\u7ebf\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7ed3\u5408\u6b64\u524d SARS \u4e0e MERS \u6eaf\u6e90\u7684\u7ecf\u9a8c\uff0c<\/span>\u7a7f\u5c71\u7532\u7b49\u91ce\u751f\u52a8\u7269\u7684\u8d70\u79c1\u3001\u8d29\u8fd0\u3001\u98df\u7528\u91ce\u5473\u7b49\u884c\u4e3a\u53ef\u80fd\u662f\u75c5\u6bd2\u7684\u4f20\u64ad\u9014\u5f84\u3002<\/span><\/p>\n


<\/p>\n

\u5f88\u5feb\uff0c2 \u6708 7 \u65e5\u7684\u4e00\u573a\u53d1\u5e03\u4f1a\u8ba9\u7a7f\u5c71\u7532\u6210\u4e3a\u7126\u70b9\u3002<\/span><\/p>\n


<\/p>\n

\u5f53\u65e5\uff0c\u534e\u5357\u519c\u4e1a\u5927\u5b66\u53ec\u5f00\u65b0\u95fb\u53d1\u5e03\u4f1a\u5ba3\u5e03\uff0c\u7a7f\u5c71\u7532\u662f\u65b0\u51a0\u75c5\u6bd2\u7684\u300c\u6f5c\u5728\u4e2d\u95f4\u5bbf\u4e3b\u300d\u3002\u8be5\u56e2\u961f\u8868\u793a\uff0c\u901a\u8fc7\u5bf9\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5206\u6790\uff0c\u53d1\u73b0\u7a7f\u5c71\u7532\u4f53\u5185\u5206\u79bb\u7684\u75c5\u6bd2\u682a\u4e0e\u76ee\u524d\u611f\u67d3\u4eba\u7684\u65b0\u51a0\u75c5\u6bd2\u6bd2\u682a\u5e8f\u5217\u76f8\u4f3c\u5ea6\u9ad8\u8fbe 99%\uff0c<\/span>\u987f\u65f6\u5f15\u53d1\u8206\u8bba\u54d7\u7136\u3002<\/span><\/p>\n


<\/p>\n

\u7d27\u63a5\u7740\uff0c\u9999\u6e2f\u5927\u5b66\u516c\u5171\u536b\u751f\u5b66\u9662\u7ba1\u8f76\u6559\u6388\u56e2\u961f\u4e0e\u5e7f\u897f\u533b\u79d1\u5927\u5b66\u80e1\u8273\u73b2\u6559\u6388\u56e2\u961f\u4e8e 2 \u6708 18 \u65e5\u5728\u9884\u5370\u672c\u8bba\u6587\u5e73\u53f0 bioRxiv \u53d1\u8868\u7814\u7a76\uff0c<\/span>\u7ed3\u8bba\u4e0e\u534e\u5357\u519c\u5927\u4e00\u81f4\uff0c\u5373\u652f\u6301\u7a7f\u5c71\u7532\u7684\u300c\u4e2d\u95f4\u5bbf\u4e3b\u8bba\u300d\u3002<\/span><\/span>\uff08\u8be6\u60c5\u53ef\u70b9\u51fb\u94fe\u63a5\u56de\u987e\uff1a\u7ba1\u8f76\u7b49\u65b0\u7814\u7a76\uff1a\u7a7f\u5c71\u7532\u53ef\u80fd\u662f\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b<\/a>\uff09<\/span><\/p>\n


<\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

bioRxiv<\/span> <\/span><\/em>\u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u7814\u7a76\u5bf9 2017 \u5e74 8 \u6708\u81f3 2018 \u5e74 1 \u6708\u53ca 2018 \u5e74 5 \u6708\u81f3 7 \u6708\u7684\u4e24\u6279\u6b21\u7a7f\u5c71\u7532\u7ec4\u7ec7\u6837\u54c1\u8fdb\u884c\u4e86\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u4e0e qPCR \u68c0\u6d4b\uff0c<\/span>\u7ed3\u679c\u8868\u660e\uff0c\u7a7f\u5c71\u7532\u7684\u80ba\u90e8\u3001\u80a0\u9053\u3001\u8840\u6db2\u7b49\u6837\u54c1\u5448\u65b0\u51a0\u75c5\u6bd2\u76f8\u5173\u7684\u51a0\u72b6\u75c5\u6bd2\u9633\u6027\uff0c\u4e0e\u65b0\u51a0\u75c5\u6bd2\u57fa\u56e0\u7ec4\u76f8\u4f3c\u5ea6\u4e3a 85.5%\uff5e92.4%\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e0e\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u7684\u53d7\u4f53\u7ed3\u5408\u57df RBD \u6c28\u57fa\u9178\u5e8f\u5217\u76f8\u4f3c\u6027\u9ad8\u8fbe 97.4%\uff0c\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u4e0e\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u53d7\u4f53\u7ed3\u5408\u57df\u6c28\u57fa\u9178\u76f8\u4f3c\u5ea6\u4e3a 89.2%\uff0c\u4e0e\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u76f8\u6bd4\uff0c\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u4e0e\u65b0\u51a0\u75c5\u6bd2\u5e8f\u5217\u76f8\u4f3c\u5ea6\u6216\u4e00\u81f4\u6027\u66f4\u9ad8\u3002<\/span><\/p>\n


<\/p>\n

\u4e24\u5929\u540e\uff0c<\/span>\u4e91\u5357\u5927\u5b66\u5f20\u5fd7\u521a\u56e2\u961f\u5728\u9884\u5370\u672c bioRxiv \u4e0a\u53d1\u8868\u7814\u7a76\uff0c\u7814\u7a76\u6837\u672c\u4e0e\u6700\u5f00\u59cb\u8ba9\u4eba\u4eec\u5173\u6ce8\u5230\u7a7f\u5c71\u7532\u7684\u90a3\u7bc7\u7814\u7a76\u4e00\u81f4\u2014\u2014\u5e7f\u4e1c\u6d77\u5173\u66fe\u622a\u83b7\u7684\u8d70\u79c1<\/span>\u7a7f\u5c71\u7532\u4e2d\uff0c\u88ab\u68c0\u51fa\u643a\u5e26\u51a0\u72b6\u75c5\u6bd2\u7684\u90a3 2 \u53ea\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

bioRxiv<\/span> \u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/p>\n

\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7ed3\u679c\u8868\u660e\uff0c\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u5728\u5168\u57fa\u56e0\u7ec4\u6c34\u5e73\u4e0a\u4e0e\u65b0\u51a0\u75c5\u6bd2\u548c\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u76f8\u4f3c\u5ea6\u5206\u522b\u4e3a 91.02% \u548c 90.55%\u3002<\/span>\u5728\u9057\u4f20\u5173\u7cfb\u4e0a\uff0c\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u7684 S1 \u86cb\u767d\u4e0e\u65b0\u51a0\u75c5\u6bd2\u7684\u5173\u7cfb\u6bd4\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u66f4\u52a0\u5bc6\u5207\u3002<\/span><\/p>\n


<\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

\u65b0\u51a0\u75c5\u6bd2\u3001\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u548c\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u5728\u5168\u57fa\u56e0\u6c34\u5e73\u4e0a\u7684\u4e00\u81f4\u6027\u6bd4\u8f83<\/span>
<\/p>\n


<\/p>\n

\u591a\u9879\u7814\u7a76\u7ed3\u8bba\u7684\u4e00\u81f4\u6027\uff0c\u8ba9\u7a7f\u5c71\u7532\u4f5c\u4e3a\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u51e0\u4e4e\u8981\u4e0e\u8759\u8760\u4f5c\u4e3a\u81ea\u7136\u5bbf\u4e3b\u7684\u53ef\u80fd\u6027\u76f8\u6bd4\u80a9\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7136\u800c\uff0c\u968f\u7740\u6b64\u524d\u5f15\u53d1\u5e7f\u6cdb\u5173\u6ce8\u7684\u534e\u5357\u519c\u5927 99% \u7ed3\u8bba\u51fa\u73b0\u7ffb\u8f66\uff0c\u7a7f\u5c71\u7532\u7684\u4e2d\u95f4\u5bbf\u4e3b\u8eab\u4efd\u518d\u6b21\u8fdb\u5165\u4e89\u8bae\u3002<\/span><\/p>\n


<\/span>
<\/p>\n

99% \u4e0e 90.4% \u7684\u300c\u6c9f\u901a\u8bef\u5dee\u300d<\/span><\/strong><\/span>
<\/span><\/p>\n


<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u7531\u4e8e\u534e\u5357\u519c\u5927\u53d1\u5e03\u4f1a\u5f53\u665a\u5e76\u672a\u540c\u6b65\u516c\u5e03\u76f8\u5173\u62a5\u544a\u6216\u8bba\u6587\uff0c\u5f88\u5feb\u5f15\u53d1\u5b66\u672f\u8d28\u7591\uff0c\u5176\u4e2d\u6700\u5927\u7684\u95ee\u9898\u662f\u6837\u672c\u6765\u6e90\u3002<\/span><\/p>\n


<\/p>\n

\u636e\u7814\u7a76\u56e2\u961f\u63a5\u53d7\u5a92\u4f53\u91c7\u8bbf\u65f6\u4ecb\u7ecd\uff0c\u9501\u5b9a\u7a7f\u5c71\u7532\u7684 1000 \u591a\u4efd\u91ce\u751f\u52a8\u7269\u4e2a\u4f53\u7684\u5b8f\u57fa\u56e0\u7ec4\u6765\u81ea\u8fd1 4 \u5e74\u95f4\u5efa\u7acb\u7684<\/span>\u300c\u91ce\u751f\u52a8\u7269\u7684\u5b8f\u57fa\u56e0\u7ec4\u5e93\u300d\u3002<\/span>\u4e5f\u5c31\u662f\u8bf4\uff0c\u6570\u636e\u6765\u6e90\u662f\u4ee5\u5f80\u5efa\u7acb\u7684\u6570\u636e\u5e93\uff0c\u800c\u975e\u672c\u6b21\u75ab\u60c5\u53d1\u751f\u540e\u7684\u52a8\u7269\u91c7\u96c6\u6837\u672c\uff0c\u6837\u672c\u4ee3\u8868\u6027\u53ef\u80fd\u5b58\u7591\u3002<\/span><\/p>\n


<\/p>\n

\u76f4\u5230\u53d1\u5e03\u4f1a\u540e\u4e24\u5468\uff0c\u534e\u5357\u519c\u5927\u7684\u5177\u4f53\u7814\u7a76\u62a5\u544a\u624d\u5728 bioRxiv <\/em>\u53d1\u5e03\u3002<\/span>\uff08\u8be6\u60c5\u53ef\u70b9\u51fb\u94fe\u63a5\u56de\u987e\uff1a\u534e\u5357\u519c\u5927\u6700\u65b0\u7814\u7a76\uff01\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u6eaf\u6e90\u6307\u5411\u7a7f\u5c71\u7532<\/a>\uff09<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u7814\u7a76<\/span>\u7ed3\u679c\u8868\u660e\uff0c\u4ece\u9a6c\u6765\u4e9a\u7a7f\u5c71\u7532\u4e2d\u5206\u79bb\u7684\u51a0\u72b6\u75c5\u6bd2\u57fa\u56e0\u4e0e\u65b0\u51a0\u75c5\u6bd2\u523a\u7a81\u8868\u9762\u7cd6\u86cb\u767d\uff08S\uff09\u5177\u6709 90.4% \u7684\u4e00\u81f4\u6027\uff0c\u5168\u57fa\u56e0\u7ec4\u5bf9\u6bd4\u663e\u793a\uff0c\u7a7f\u5c71\u7532\u548c\u65b0\u51a0\u75c5\u6bd2\u7684 DNA \u76f8\u4f3c\u5ea6\u4e3a 90.3%\u2014\u2014<\/span>\u76f8\u4f3c\u6027\u8fdc\u4f4e\u4e8e\u6b64\u524d\u53d1\u5e03\u4f1a\u516c\u5e03\u7684\u6570\u503c 99%\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u56e2\u961f\u5bf9\u6b64\u89e3\u91ca\u9053\uff0c\u8fd9\u4e00\u533a\u522b\u6e90\u4e8e\u300c\u751f\u7269\u4fe1\u606f\u56e2\u961f\u548c\u5b9e\u9a8c\u56e2\u961f\u4e4b\u95f4\u4e00\u6b21\u4ee4\u4eba\u5c34\u5c2c\u7684\u6c9f\u901a\u5931\u8bef\u300d\u3002<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

\u65b0\u51a0\u75c5\u6bd2\u3001SARS \u75c5\u6bd2\u3001\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u4e0e\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u7684\u5168\u57fa\u56e0\u5e8f\u5217\u4e00\u81f4\u6027\u5bf9\u6bd4<\/span><\/p>\n


<\/p>\n

\u5f88\u5feb\uff0c\u65b0\u7684\u7814\u7a76\u663e\u793a\uff0c\u7a7f\u5c71\u7532\u53ef\u80fd\u4e0d\u662f\u4e2d\u95f4\u5bbf\u4e3b\u3002<\/span><\/p>\n


<\/span><\/p>\n

2 \u6708 21 \u65e5\uff0c\u5e7f\u4e1c\u7701\u751f\u7269\u8d44\u6e90\u5e94\u7528\u7814\u7a76\u6240\u9648\u91d1\u5e73\u56e2\u961f\u5728 bioRxiv<\/em> \u4e0a\u53d1\u8868\u7814\u7a76\uff0c\u8bc4\u4f30 2019 \u5e74 3 \u6708\u6d77\u5173\u67e5\u8d27\u7684\u60a3\u75c5\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u3001\u65b0\u51a0\u75c5\u6bd2\u548c\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u4e4b\u95f4\u7684\u9057\u4f20\u5173\u7cfb\uff0c\u5f97\u51fa\u4e86\u66f4\u52a0\u4fdd\u5b88\u7684\u7b54\u6848\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

bioRxiv<\/span> \u8bba\u6587\u622a\u56fe<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005\u4ece 3 \u53ea\u7a7f\u5c71\u7532\u6837\u672c\u4e2d\u6536\u96c6\u5230 29380 \u4e2a\u6838\u82f7\u9178\uff0c\u4ece\u60a3\u75c5\u9a6c\u6765\u4e9a\u7a7f\u5c71\u7532\u4e2d\u5206\u79bb\u7684\u51a0\u72b6\u75c5\u6bd2 S \u86cb\u767d\u57fa\u56e0\u4e0e\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2 S \u86cb\u767d\u57fa\u56e0\u5e8f\u5217\u4e00\u81f4\u6027\u4ec5\u4e3a 83.05%\uff0c\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u548c\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u57fa\u56e0\u5e8f\u5217\u5b58\u5728 90.23% \u4e00\u81f4\u6027\uff0c<\/span>\u8fdc\u4f4e\u4e8e\u534e\u5357\u519c\u5927\u4e0e\u7ba1\u8f76\u56e2\u961f\u7684\u4e24\u9879\u7814\u7a76\u7ed3\u679c\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728\u9057\u4f20\u5173\u7cfb\u4e0a\uff0c\u8fd9\u9879\u7814\u7a76\u4e5f\u5f97\u51fa\u4e86\u4e0e\u5f20\u5fd7\u521a\u56e2\u961f\u76f8\u53cd\u7684\u7ed3\u8bba\uff1a\u4e0e\u8759\u8760\u51a0\u72b6\u75c5\u6bd2 RaTG13 \u76f8\u6bd4\uff0c<\/span>\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u5728\u5168\u57fa\u56e0\u7ec4\u6c34\u5e73<\/span>\u79bb\u65b0\u51a0\u75c5\u6bd2\u7684\u8fdb\u5316\u8ddd\u79bb\u66f4\u8fdc\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u65b0\u51a0\u75c5\u6bd2 S \u86cb\u767d\u4e2d\u7684\u4e00\u6bb5\u5e8f\u5217\u5728\u7a7f\u5c71\u7532\u51a0\u72b6\u75c5\u6bd2\u548c\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\u4e2d\u5747\u4e0d\u5b58\u5728\uff0c\u8fd9\u610f\u5473\u7740\uff0c\u8fd9\u6bb5\u5e8f\u5217\u53ef\u80fd\u5728\u75c5\u6bd2\u4f20\u64ad\u8fc7\u7a0b\u4e2d\u7531\u5176\u4ed6\u5bbf\u4e3b\u63d2\u5165\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u56e0\u6b64\uff0c\u7814\u7a76\u7ed3\u8bba\u5c1a\u4e0d\u652f\u6301\u7a7f\u5c71\u7532\u4f5c\u4e3a\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\uff0c\u4f46\u4e0d\u6392\u9664\u65b0\u51a0\u75c5\u6bd2\u5728\u7a7f\u5c71\u7532\u4e2d\u53d1\u751f\u75c5\u6bd2\u91cd\u7ec4\u7684\u53ef\u80fd\u6027\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u4e89\u8bae\u7a7f\u5c71\u7532\uff1a\u534e\u5357\u519c\u5927\u516c\u5e03\u7ed3\u679c\u5b58\u5728\u5931\u8bef\uff0c\u65b0\u51a0\u75c5\u6bd2\u4e2d\u95f4\u5bbf\u4e3b\u4e4b\u8c1c\"
<\/p>\n

4 \u79cd\u51a0\u72b6\u75c5\u6bd2\u5728 S \u86cb\u767d\u4e0a\u7684\u5e8f\u5217\u5dee\u5f02\uff08bioRxiv<\/span> \u8bba\u6587\u622a\u56fe<\/span>\uff09<\/span><\/p>\n


<\/p>\n

\u6709\u52a8\u7269\u4f20\u67d3\u75c5\u4e13\u5bb6\u8868\u793a\uff0c\u81ea\u7136\u754c\u4e2d\u75c5\u6bd2\u4f20\u64ad\u901a\u5e38\u96be\u4ee5\u786e\u5b9a\u300c\u4e2d\u95f4\u73af\u8282\u300d\uff0c\u56e0\u6b64\u5728\u52a8\u7269\u4f20\u67d3\u75c5\u7814\u7a76\u4e2d\uff0c\u901a\u5e38\u4e0d\u8c08\u300c\u4e2d\u95f4\u5bbf\u4e3b\u300d\u6982\u5ff5\uff0c\u800c\u4ee5<\/span>\u300c\u6613\u611f\u52a8\u7269\u300d<\/span>\u6982\u5ff5\u66ff\u4ee3\u3002\u8fd9\u662f\u7531\u6613\u611f\u52a8\u7269\u5728\u4f20\u64ad\u8fc7\u7a0b\u4e2d\u7684\u7279\u6027\u51b3\u5b9a\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u6839\u636e<\/span>\u79d1\u8d6b\u6cd5\u5219<\/span>\uff0c\u786e\u5b9a\u4f20\u67d3\u75c5\u6613\u611f\u52a8\u7269\u5e94\u5f53\u540c\u65f6\u6ee1\u8db3\u4ee5\u4e0b 3 \u70b9\uff1a<\/span><\/p>\n


<\/span><\/p>\n

1. \u5728\u5065\u5eb7\u7684\u52a8\u7269\u4e2d\u65e0\u6cd5\u5206\u79bb\u51fa\u65b0\u51a0\u75c5\u6bd2\uff0c\u4f46\u80fd\u591f\u4ece\u60a3\u75c5\u52a8\u7269\u4f53\u5185\u5206\u79bb\u51fa\u75c5\u6bd2\uff1b<\/span><\/p>\n


<\/span><\/p>\n

2. \u8be5\u5206\u79bb\u51fa\u6765\u7684\u75c5\u6bd2\u80fd\u5728\u4f53\u5916\u7eaf\u57f9\u517b\uff1b<\/span><\/p>\n


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3. \u7528\u7eaf\u57f9\u517b\u7684\u75c5\u6bd2\u611f\u67d3\u5065\u5eb7\u4e2a\u4f53\uff0c\u80fd\u591f\u4f7f\u5065\u5eb7\u52a8\u7269\u60a3\u540c\u79cd\u75be\u75c5\uff0c\u5728\u5176\u4f53\u5185\u4e5f\u80fd\u5206\u79bb\u51fa\u540c\u79cd\u75c5\u6bd2\u3002<\/span><\/p>\n


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\u6211\u4eec\u671f\u5f85\u66f4\u591a\u7684\u7814\u7a76\u8865\u5145\u8bc1\u636e\u94fe\u3002<\/span>\uff08\u8d23\u4efb\u7f16\u8f91\uff1agyouza\uff09<\/span><\/p>\n


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\u9898\u56fe\u6765\u6e90\uff1a\u56fe\u866b\u521b\u610f<\/span>  <\/span><\/p>\n

\u53c2\u8003\u6765\u6e90\uff1a<\/span><\/section>\n
1.http:\/\/news.sciencenet.cn\/htmlnews\/2020\/2\/435499.shtm<\/span><\/section>\n
2.Ji W, Wang W, Zhao X, et al. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross\u2010species transmission from snake to human[J]. Journal of medical virology, 2020.<\/span><\/section>\n
3.Zhang Z, Wu Q, Zhang T. Pangolin homology associated with 2019-nCoV[J]. bioRxiv, 2020.<\/span><\/section>\n
4.Lam T T Y, Shum M H H, Zhu H C, et al. Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China[J]. bioRxiv, 2020.<\/span><\/section>\n
5.Liu P, Jiang J Z, Hua Y, et al. Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV)?[J]. bioRxiv, 2020.<\/span><\/section>\n
6.Xiao K, Zhai J, Feng Y, et al. Isolation and Characterization of 2019-nCoV-like Coronavirus from Malayan Pangolins[J]. bioRxiv, 2020.<\/span><\/section>\n
7.Liu, Z., Xiao, X., Wei, X., Li, J., Yang, J., Tan, H., Zhu, J., Zhang, Q., Wu, J. and Liu, L. (2020), Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS\u2010CoV\u20102. J Med Virol. Accepted Author Manuscript. <\/span><\/section>\n
8.https:\/\/www.sciencenews.org\/article\/snakes-probably-not-source-spread-new-coronavirus-outbreak-china<\/span><\/section>\n

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