{"id":134827,"date":"2020-03-06T05:51:20","date_gmt":"2020-04-21T03:35:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/134827\/"},"modified":"2020-04-21T11:35:51","modified_gmt":"2020-04-21T03:35:51","slug":"29233f7bd2","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/134827\/","title":{"rendered":"\u4e34\u5e8a\u5e94\u5ba1\u614e\u4f7f\u7528\u6c2f\u55b9 | \u65b0\u51a0\u75c5\u6bd2\u70ed\u70b9\u836f\u7269\u89e3\u6790"},"content":{"rendered":"
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\u57fa\u4e8e\u5927\u91cf\u6587\u732e\uff0c\u6211\u4eec\u603b\u7ed3\u4e86\u6c2f\u55b9\u548c\u7f9f\u6c2f\u55b9\u7684\u4e34\u5e8a\u4f7f\u7528\u60c5\u51b5\u5e76\u505a\u4e86\u4e00\u4e2a\u7b80\u5355\u7684\u5bf9\u6bd4<\/span>\uff0c\u4f9b\u4e34\u5e8a\u4e00\u7ebf\u533b\u751f\u548c\u76f8\u5173\u79d1\u7814\u4eba\u5458\u53c2\u8003\u2193\u2193\u2193<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n

\n

\"\u4e34\u5e8a\u5e94\u5ba1\u614e\u4f7f\u7528\u6c2f\u55b9<\/p>\n

\"\u4e34\u5e8a\u5e94\u5ba1\u614e\u4f7f\u7528\u6c2f\u55b9<\/section>\n

<\/section>\n<\/section>\n
\n

<\/span><\/p>\n

\u6ce8\uff1a<\/span>\u8868\u4e2d\u6807\u7ea2\u5355\u4f4d\u540c\u65f6\u5f00\u5c55\u4e86\u78f7\u9178\u6c2f\u55b9\u548c\u786b\u9178\u7f9f\u6c2f\u55b9\u4e24\u79cd\u836f\u7269\u4f5c\u4e3a\u5e72\u9884\u7ec4\u7684\u5f00\u653e\u6027\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002<\/span><\/section>\n

<\/section>\n
\u622a\u6b62 3 \u6708 5 \u65e5\uff0c\u5168\u56fd\u5171\u8ba1\u7533\u62a5\u4e86 22 \u9879\u4e0e\u6c2f\u55b9\u6216\u7f9f\u6c2f\u55b9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6700\u65b0\u7684\u4e00\u9879\u5173\u4e8e\u7f9f\u6c2f\u55b9\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u62a5\u4e8e 3 \u6708 1 \u65e5\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u4f46\u540c\u65f6\uff0c\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u548c\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u66fe\u5728 2 \u6708 12 \u65e5\u7533\u62a5\u8fc7 3 \u9879\u5173\u4e8e\u7f9f\u6c2f\u55b9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u62a5\uff0c\u76ee\u524d\u5747\u5df2\u64a4\u9500\uff0c\u767b\u8bb0\u5728\u6848\u7684\u64a4\u56de\u539f\u56e0\u4e3a\u300c\u7f3a\u4e4f\u60a3\u8005\u300d\u3002<\/span><\/section>\n


<\/p>\n


<\/p>\n<\/section>\n

\n
\n
\n
\n
\n

\u4e13\u5bb6\u610f\u89c1\uff1a\u5173\u4e8e\u614e\u7528\u78f7\u9178\u6c2f\u55b9\u4e34\u5e8a\u6cbb\u7597\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u5efa\u8bae<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

\u53d7\u9080\u4e13\u5bb6\uff1a\u738b\u6d69\u7136\u535a\u58eb\uff0c\u6c88\u9633\u836f\u79d1\u5927\u5b66\u836f\u5b66\u4e13\u4e1a\uff0c\u524d\u8bfa\u534e\u7814\u7a76\u6240\u5fc3\u810f\u6bd2\u7406\u5b9e\u9a8c\u5ba4\u4e3b\u4efb<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

\u5173\u4e8e\u78f7\u9178\u6c2f\u55b9\u4e34\u5e8a\u6cbb\u7597\u7684\u4e13\u5bb6\u610f\u89c1\u5982\u4e0b\uff1a<\/span><\/p>\n


<\/p>\n

\u6211\u548c\u5176\u4ed6\u533b\u5b66\u836f\u5b66\u540c\u884c\u6ce8\u610f\u5230\u7b2c\u516d\u7248\u65b0\u51a0\u6cbb\u7597\u6307\u5bfc\u5f53\u4e2d\u78f7\u9178\u6c2f\u55b9\u6cbb\u7597\u65b9\u6848\u4e2d\u5b58\u5728\u6c2f\u55b9\u5242\u91cf\u8fc7\u5927\uff0c\u7528\u836f\u5468\u671f\u8fc7\u957f\u7684\u95ee\u9898\u3002<\/span>\u6c2f\u55b9\u7528\u6765\u6cbb\u7597\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u867d\u7136\u6709\u6548\uff0c\u4f46\u6309\u7167\u73b0\u884c\u6307\u5bfc\u5f88\u53ef\u80fd\u5bfc\u81f4\u5927\u89c4\u6a21\u836f\u5bb3\uff0c\u751a\u81f3\u60a3\u8005\u731d\u6b7b\u7684\u60c5\u51b5\u53d1\u751f\uff0c\u6545\u7279\u6b64\u63d0\u8bf7\u4e34\u5e8a\u4e00\u7ebf\u533b\u751f\u4eec\u5728\u6cbb\u7597\u65b0\u51a0\u75c5\u4eba\u65f6\u591a\u52a0\u6ce8\u610f\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u78f7\u9178\u6c2f\u55b9\u7684\u4e34\u5e8a\u836f\u4ee3\u52a8\u529b\u5b66\u62a5\u9053\u8bf4\u660e\uff0c\u5176\u53e3\u670d\u534a\u8870\u671f\u957f\u8fbe 5\uff5e60 \u5929\uff0c\u534a\u8870\u671f\u4e2d\u4f4d\u6570\u5728 21\uff5e30 \u5929[14]\uff0c\u6c2f\u55b9\u4e34\u5e8a\u81f4\u6b7b\u91cf\u5728 3\uff5e5 \u514b[11]\uff0c\u82e5\u6309\u7b2c\u516d\u7248\u65b9\u6848\u5b8c\u6210 500mg\/\u6b21\uff0c\u4e00\u5929\u4e24\u6b21\uff0c\u7528\u836f 10 \u5929\u7597\u7a0b[13]\uff0c\u60a3\u8005\u4f53\u5185\u5b58\u7559\u7684\u6c2f\u55b9\u52bf\u5fc5\u8d85\u8fc7\u81f4\u6b7b\u91cf\u7684\u4e24\u500d\u4ee5\u4e0a\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u8003\u91cf\uff0c\u6211\u548c\u5176\u4ed6\u533b\u836f\u76f8\u5173\u9886\u57df\u7814\u7a76\u4eba\u5458\u63d0\u8bf7\u8981\u975e\u5e38\u5173\u6ce8\u6c2f\u55b9\u7684\u4f7f\u7528\u3002\u56e0\u4e3a\u6c2f\u55b9\u6297\u75c5\u6bd2\u673a\u5236\u662f\u4f9d\u9760\u9178\u78b1\u53cd\u5e94\u4e2d\u548c\u6eb6\u9176\u4f53\u9178\u6027\uff0c\u6291\u5236\u75c5\u6bd2\u8131\u58f3\uff0c\u5f88\u591a\u66f4\u5b89\u5168\u7684\u4e34\u5e8a\u836f\u7269\u6bd4\u5982\u7f9f\u6c2f\u55b9\uff0c\u4e5f\u4e00\u6837\u53ef\u4ee5\u8fbe\u5230\u540c\u6837\u7684\u6cbb\u7597\u6548\u679c\u800c\u65e0\u660e\u663e\u526f\u4f5c\u7528\u3002<\/span><\/p>\n


<\/p>\n

\u6211\u4eec\u5efa\u8bae\u7528\u7f9f\u6c2f\u55b9\u4ee3\u66ff\u6c2f\u55b9\uff0c\u6216\u8005\u5927\u5e45\u5ea6\u964d\u4f4e\u73b0\u884c\u6c2f\u55b9\u4e34\u5e8a\u6307\u5bfc\u7684\u836f\u7269\u4f7f\u7528\u91cf\u3002<\/span><\/strong><\/span><\/p>\n

<\/span><\/strong><\/span><\/p>\n

\u6b66\u6c49\u75c5\u6bd2\u6240\/\u53d1\u5e03\u7684\u6c2f\u55b9\u534a\u6291\u5236\u7387\u4ec5\u5728 1uM\/L \u5de6\u53f3[12]\uff0c\u6587\u732e\u62a5\u9053\u670d\u7528 1g \u6c2f\u55b9\u5373\u53ef\u5b9e\u73b0 5uM\/L \u7684\u4eba\u4f53\u8840\u836f\u6d53\u5ea6[11]\u3002<\/span>\u6c2f\u55b9\u548c\u7f9f\u6c2f\u55b9\u90fd\u53ef\u5728\u80ba\u6ce1\u5185\u6eb6\u9176\u4f53\u548c\u55dc\u9507\u6027\u677f\u5c42\u5c0f\u4f53\u5927\u91cf\u84c4\u79ef\uff0c\u901a\u8fc7\u4e2d\u548c\u6eb6\u9176\u4f53 pH \u8d77\u5230\u6297\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u4f5c\u7528\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u6c2f\u55b9\u5728\u80ba\u90e8\u5bcc\u96c6\u53ef\u8fbe\u5230\u8840\u6db2\u6d53\u5ea6\u7684 200\uff5e700 \u500d\u4ee5\u4e0a[14]\u3002\u53e3\u670d 1g \u6c2f\u55b9\u5373\u53ef\u5728\u80ba\u90e8\u8fbe\u5230 2500uM\/L \u7684\u6cbb\u7597\u6d53\u5ea6\uff0c\u540c\u65f6\u56e0\u4e3a\u6c2f\u55b9\u534a\u8870\u671f\u6781\u957f\uff0c\u5728\u7b2c\u4e00\u5929\u51b2\u51fb\u5242\u91cf\u4e4b\u540e\uff0c\u4ec5\u9700\u8f83\u5c11\u836f\u7269\u5373\u53ef\u7ef4\u6301\u6709\u6548\u8840\u836f\u6d53\u5ea6\uff0cFDA \u5bf9\u4e8e\u78f7\u9178\u6c2f\u55b9\u6297\u759f\u75be\u7684\u5242\u91cf\u4e3a\u6210\u4eba\uff1a\u521d\u59cb\u5242\u91cf\u4e3a 1g \u76d0<\/span>\uff08= 600mg\u78b1\uff09<\/span>\uff0c\u7136\u540e\u5728\u516d\u81f3\u516b\u5c0f\u65f6\u540e\u518d\u52a0 500mg<\/span>\uff08= 300mg \u78b1\uff09<\/span>\uff0c\u5e76\u8fde\u7eed\u4e24\u6b21\u5206\u522b\u670d\u7528 500mg<\/span>\uff08= 300mg\u78b1\uff09<\/span>\u5929\u3002\u4e09\u5929\u5185 2.5 \u514b\u78f7\u9178\u6c2f\u55b9\u6216 1.5 \u514b\u78b1\u7684\u603b\u5242\u91cf\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u800c\u56fd\u5bb6\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u6cbb\u7597\u7b2c\u516d\u7248\u6307\u5bfc\u73b0\u884c\u6307\u5bfc\u610f\u89c1\u5efa\u8bae 1000mg\/\u5929\u517110\u78f7\u9178\u6c2f\u55b9\u4f7f\u7528\u5242\u91cf\uff0c\u5b9e\u9645\u4e0a\u5df2\u8fdc\u8fdc\u8d85\u8fc7\u4e86\u6cbb\u7597\u75c5\u6bd2\u6240\u9700\u7684\u7406\u60f3\u836f\u7269\u6d53\u5ea6\u548c\u5b89\u5168\u7684\u7ed9\u836f\u5468\u671f\u3002\u6211\u4eec\u8ba4\u4e3a\u8d85\u8fc7\u6cbb\u7597\u5242\u91cf\u4f53\u73b0\u66f4\u591a\u7684\u662f\u6bd2\u526f\u4f5c\u7528\u800c\u975e\u7597\u6548\uff0c\u5728\u60a3\u8005\u4e2d\u5bfc\u81f4\u5927\u9762\u79ef\u6c2f\u55b9\u4e0d\u826f\u53cd\u5e94\u751a\u81f3\u60a3\u8005\u6b7b\u4ea1\u7684\u53ef\u80fd\u6027\u4e0d\u53ef\u5ffd\u89c6\u3002\u5728 1988 \u5e74\u51fa\u7248\u7684\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u62a5\u9053\u7684\u56de\u987e\u6027\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u8fde\u7eed\u670d\u7528 3\uff5e5g\u6c2f\u55b9\u5373\u53ef\u81f4\u6b7b\uff0c\u5bf9\u7167\u7ec4<\/span>\uff08\u672a\u53ca\u65f6\u91c7\u53d6\u7cbe\u51c6\u62a2\u6551\u63aa\u65bd\uff09<\/span>\u4e2d 11 \u4eba\u6709 10 \u4eba\u6b7b\u4ea1[11]\u3002<\/span><\/p>\n


<\/p>\n

\u6c2f\u55b9\u4e9a\u6025\u6027\u4e2d\u6bd2\u540e\u5e38\u89c1\u7684\u89c6\u7f51\u819c\u75c5\u662f\u91cd\u8981\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4e34\u5e8a\u5178\u578b\u8868\u73b0\u4e3a\u300c<\/span>\u9776\u4e2d\u5fc3\u773c<\/span>\uff08Bull\u2019seye\uff09<\/span>\u300d\uff0c\u5373\u89c6\u7f51\u819c\u4e2d\u5fc3\u51f9\u662f\u5b8c\u6574\u7684\uff0c\u5468\u56f4\u7ed5\u6709\u8131\u8272\u7d20\u73af\uff0c\u5e76\u88ab\u6563\u5728\u7684\u8272\u7d20\u589e\u591a\u3002\u4e34\u5e8a\u53d1\u751f\u6c2f\u55b9\u6bd2\u6027\u4e4b\u524d\u5f80\u5f80\u60a3\u8005\u4f1a\u6709\u89c6\u89c9\u5f02\u5e38\uff0c\u53d1\u751f\u6b64\u7c7b\u5f02\u5e38\u5c31\u5e94\u5f53\u9a6c\u4e0a\u505c\u836f\u3002\u82e5\u60a3\u8005\u660f\u8ff7\u65e0\u6cd5\u81ea\u8ff0\u75c7\u72b6\uff0c\u5219\u5e94\u8be5\u7d27\u5bc6\u89c2\u5bdf\u5fc3\u7535\u56fe ST-\u6ce2\u6bb5\u538b\u7f29, T  \u6ce2\u5012\u7f6e\u548c QT \u95f4\u671f\u5ef6\u957f\u7b49\u5f02\u5e38\u73b0\u8c61[16]\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u5916\uff0c\u6c2f\u55b9\u5728\u8840\u6db2\u7ec6\u80de\u5185\u5927\u91cf\u957f\u671f\u5bcc\u96c6<\/span>\uff08\u5355\u6b21\u7528\u836f\u540e60\u5929\u548c\u4e00\u5e74\u4ee5\u540e\u4ecd\u53ef\u5728\u8840\u6db2\u548c\u5c3f\u6db2\u4e2d\u68c0\u6d4b\u5230\u6c2f\u55b9[14]\uff09<\/span>\uff0c\u5927\u91cf\u836f\u7269\u4f1a\u6291\u5236\u6297\u539f\u5448\u9012\u7ec6\u80de\u5bf9\u6297\u539f\u7684\u964d\u89e3\u548c\u5448\u9012\u8fc7\u7a0b\u514d\u75ab\u7ec6\u80de\u7684\u8fc7\u7a0b\u4ea7\u751f\u957f\u671f\u7684\u6291\u5236\uff0c\u5bfc\u81f4\u65b0\u51a0\u60a3\u8005\u6dcb\u5df4\u7ec6\u80de\u96be\u4ee5\u6709\u6548\u4ea7\u751f\u6297\u4f53\u5f62\u6210\u957f\u671f\u4f53\u6db2\u514d\u75ab\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e34\u5e8a\u4e0a\u5e38\u7528\u6c2f\u55b9\u548c\u7f9f\u6c2f\u55b9\u7684\u8fd9\u4e9b\u7279\u6027\u6cbb\u7597\u514d\u75ab\u7cfb\u7edf\u75be\u75c5\u6bd4\u5982\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7b49[15]\uff0c\u4f46\u8fd9\u6837\u52bf\u5fc5\u4f1a\u62d6\u5ef6\u65b0\u51a0\u75c5\u6bd2\u60a3\u8005\u4f9d\u9760\u81ea\u8eab\u514d\u75ab\u529b\u6062\u590d\u7684\u901f\u5ea6\uff0c\u800c\u4e14\u5373\u4f7f\u5728\u521d\u671f\u6cbb\u7597\u540e\u4e34\u5e8a\u6cbb\u6108\uff0c\u751a\u81f3\u6838\u9178\u68c0\u6d4b\u9690\u6027\uff0c\u4ecd\u6709\u4e0d\u5c11\u75c5\u6bd2\u56e0\u4e3a\u673a\u4f53\u65e0\u6cd5\u6709\u6548\u4ea7\u751f\u8db3\u591f\u548c\u591a\u6837\u5316\u7684\u6297\u4f53\u800c\u518d\u6b21\u590d\u53d1\u6216\u518d\u6b21\u88ab\u611f\u67d3\uff0c\u8fd9\u5bf9\u4e8e\u75be\u75c5\u7684\u957f\u671f\u63a7\u5236\u663e\u7136\u662f\u975e\u5e38\u4e0d\u5229\u7684\uff0c\u6240\u4ee5\u6211\u4eec\u4e5f\u5efa\u8bae\u5c3d\u91cf\u7f29\u77ed\u6c2f\u55b9\u7684\u4e34\u5e8a\u4f7f\u7528\u65f6\u95f4\uff0c\u5728\u81ea\u8eab\u514d\u75ab\u529b\u53ef\u4ee5\u5e94\u4ed8\u7684\u60c5\u51b5\u4e0b\u8ba9\u75c5\u4eba\u81ea\u5df1\u6062\u590d\u5bf9\u75c5\u6bd2\u7684\u514d\u75ab\u529b\u3002<\/span><\/p>\n


<\/p>\n

\u9488\u5bf9\u4f7f\u7528\u6c2f\u55b9\u5df2\u7ecf\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u4f7f\u7528 1988 \u5e74\u65b0\u82f1\u683c\u5170\u4e09\u8054\u65b9\u6848\u6765\u6cbb\u7597[11]\uff1a\u673a\u68b0\u901a\u6c14\uff0c\u5730\u897f\u6cee<\/span>(Diazepam)<\/span>\u9759\u8109 1-2mg\/\u516c\u65a4\/\u5929\u6ef4\u6ce8\uff0c\u5fc5\u8981\u65f6\u4f7f\u7528\u80be\u4e0a\u817a\u7d20\u964d\u4f4e\u6c2f\u55b9\u5fc3\u810f\u6bd2\u6027\u3002\u53e6\u5916\u7531\u4e8e\u6c2f\u55b9\u4e3a\u751f\u7269\u78b1\uff0c\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u5229\u4e8e\u6392\u51fa\uff0c\u53ef\u4ee5\u4f7f\u7528\u6c2f\u5316\u94f5\u5408\u7528\u52a0\u901f\u6392\u6cc4\uff0c\u964d\u4f4e\u6c2f\u55b9\u8840\u4e2d\u6d53\u5ea6\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u672c\u6587\u4e2d\u7684\u89c2\u70b9\u548c\u5efa\u8bae\u5f97\u5230\u4e1a\u5185\u540c\u884c\u795d\u8d8a(Daniel Zhu)\u535a\u58eb\u7684\u8ba4\u540c\u4e0e\u652f\u6301<\/span><\/p>\n

**\u795d\u8d8a\u535a\u58eb\u73b0\u5728\u4efb CSL Behring \u5168\u7403\u4e34\u5e8a\u5b89\u5168\u603b\u76d1\u3002\u66fe\u4efb\u963f\u65af\u5229\u5eb7\u53ca Sucampo-pharmaceuticals-inc.\u5168\u7403\u6bd2\u7406\u98ce\u9669\/\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u526f\u603b\u76d1\u3002<\/span><\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n

\u6700\u65b0\u6d88\u606f<\/span><\/strong><\/p>\n<\/section>\n

\n


<\/p>\n

\u6211\u4eec\u4ee5\u4e0a\u7684\u7814\u7a76\u4e0e\u7ed3\u8bba\u4e5f\u5728 2 \u6708 21 \u65e5\u5f97\u5230\u4e86\u6e56\u5317\u7701\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u7684\u5370\u8bc1\u3002\u6e56\u5317\u7701\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u5411\u6e56\u5317\u5404\u5e02\u3001\u5dde\u3001\u76f4\u7ba1\u5e02\u536b\u5065\u59d4\u53ca\u90e8\u7701\u5c5e\u533b\u7597\u673a\u6784\u4e0b\u53d1\u300a\u5173\u4e8e\u4e25\u5bc6\u89c2\u5bdf\u78f7\u9178\u6c2f\u55b9\u4f7f\u7528\u4e0d\u826f\u53cd\u5e94\u7684\u901a\u77e5\u300b\u3002<\/span><\/p>\n


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\"\u4e34\u5e8a\u5e94\u5ba1\u614e\u4f7f\u7528\u6c2f\u55b9<\/span><\/p>\n


<\/span><\/p>\n

\u901a\u77e5\u63d0\u53ca\uff0c \u300c\u6839\u636e\u4e2d\u56fd\u79d1\u5b66\u9662\u6b66\u6c49\u75c5\u6bd2\u6240\u901a\u62a5\uff0c\u8be5\u836f\u5728\u6210\u4eba\u4e2d\u7684\u81f4\u6b7b\u5242\u91cf 2\uff5e4g\uff0c\u800c\u4e14\u662f\u6025\u6027\u81f4\u6b7b\u3002\u8bf7\u5404\u5b9a\u70b9\u533b\u7597\u673a\u6784\u5728\u4f7f\u7528\u8be5\u836f\u7269\u8fc7\u7a0b\u4e2d\u8fdb\u884c\u4e25\u5bc6\u89c2\u5bdf\uff0c\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\u7684\u4e2a\u6848\u4fe1\u606f\u8bf7\u53ca\u65f6\u62a5\u544a\u7701\u536b\u751f\u5065\u5eb7\u59d4\u3002\u300d<\/span><\/strong><\/span><\/p>\n


<\/p>\n

2 \u6708 24 \u65e5\uff0c\u667a\u63f4\u7ec4-\u533b\u836f\u5c0f\u7ec4\u6b63\u5f0f\u8054\u540d\u547c\u5401\u4e00\u7ebf\u4eba\u5458\u8c28\u614e\u4f7f\u7528\u78f7\u9178\u6c2f\u55b9\u4e34\u5e8a\u6cbb\u7597\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u30023 \u6708 3 \u65e5\uff0c\u5728\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u4e03\u7248\uff09\u300b\u4e2d\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u4fee\u8ba2\u4e86\u5173\u4e8e\u6c2f\u55b9\u7528\u4e8e\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u6700\u65b0\u7528\u6cd5\uff1a\u9002\u7528\u4e8e 18\uff5e65 \u5c81\u6210\u4eba\uff1a\u4f53\u91cd\u5927\u4e8e 50kg \u8005\uff0c500mg\/\u6b21\uff0c\u6bcf\u65e5 2 \u6b21\uff0c\u7597\u7a0b 7 \u65e5\uff1b\u4f53\u91cd\u5c0f\u4e8e 50kg\uff0c\u7b2c 1\uff5e2 \u65e5\u4e3a 500mg\/\u6b21\uff0c\u6bcf\u65e5 2 \u6b21\uff0c\u7b2c 3\uff5e7 \u65e5 500mg\/\u6b21\uff0c\u6bcf\u65e5 1 \u6b21\u3002\u540c\u65f6\u5f3a\u8c03\uff0c\u5e94\u6ce8\u610f\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u3001\u7981\u5fcc\u75c7\u4ee5\u53ca\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7b49\u95ee\u9898\u3002<\/span><\/p>\n<\/section>\n

\n

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\u672c\u6587\u9996\u53d1\u4e8e\u516c\u4f17\u53f7\uff1a\u4e2d\u7f8e\u5065\u5eb7\u5cf0\u4f1a\uff0c\u6388\u6743\u53d1\u5e03<\/span><\/p>\n

\u8d23\u4efb\u7f16\u8f91\uff1a\u674e\u827e\u598d \u5468\u5e7f\u5b87  \u7f16\u8f91\uff1a\u6c6a\u5c11\u4f2f  \u6821\u5bf9\uff1a\u5f20\u743c \u9648\u663e\u6167<\/span><\/p>\n

\u9898\u56fe\u6765\u6e90\uff1a<\/span>\u56fe\u866b\u521b\u610f<\/span><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n


<\/p>\n

\u53c2\u8003\u6765\u6e90\uff1a<\/span><\/p>\n

[1]. \u79d1\u6280\u90e8\uff1a\u53ef\u4ee5\u660e\u786e\u78f7\u9178\u6c2f\u55b9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u5177\u6709\u7597\u6548\u3002\uff082020, Feb 17\uff09Retrieved from: https:\/\/m.chinanews.com\/wap\/detail\/zw\/gn\/2020\/02-17\/9094791.shtml<\/span><\/p>\n

[2]. \u65b0\u4eac\u62a5\uff1a\u6b66\u5927\u4eba\u6c11\u533b\u966220\u4f8b\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u4f7f\u7528\u7f9f\u6c2f\u55b9\u540e\u660e\u663e\u597d\u8f6c Retrieved from: <\/span>https:\/\/mp.weixin.qq.com\/s\/mm5oZ8kAwOoVudFJrdLsVw<\/span><\/a><\/p>\n

[3]. Browning, D. J. (2014). Pharmacology of chloroquine and hydroxychloroquine. In Hydroxychloroquine and chloroquine retinopathy (pp. 35-63). Springer, New York, NY.<\/span><\/p>\n

[4]. Retrieved from: http:\/\/virological.org\/t\/analysis-of-wuhan-coronavirus-deja-vu\/357\/2<\/span><\/p>\n

[5]. Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, Seidah NG, Nichol ST. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005 Aug 22;2:69.<\/span><\/p>\n

[6]. Savarino A, Boelaert JR, Cassone A, Majori G, Cauda R. Effects of chloroquine on viral infections: an old drug against today’s diseases? Lancet Infect Dis. 2003 Nov;3(11):722-7.<\/span><\/p>\n

[7]. \u6c2f\u55b9\u8bf4\u660e\u4e66\uff08Dailymed\uff09\uff1ahttps:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=f398f8a9-92f3-47cb-81c2-6078806a464d<\/span><\/p>\n

[8]. \u5173\u4e8e\u5370\u53d1\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u516d\u7248\uff09\u7684\u901a\u77e5\uff1ahttp:\/\/www.gov.cn\/zhengce\/zhengceku\/2020-02\/19\/content_5480948.htm<\/span><\/p>\n

[9]. \u4e34\u5e8a\u7814\u7a76\u4fe1\u606f\u6765\u6e90\uff1a\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3http:\/\/www.chictr.org.cn<\/span><\/p>\n

[10]. \u7f9f\u6c2f\u55b9\u8bf4\u660e\u4e66\uff08Dailymed\uff09\uff1ahttps:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=452092b4-7a8f-4d19-8113-f1c2a948d3d8<\/span><\/p>\n

[11]. Riou B., Barriot P., Rimailho A., Baud F.J.,  Treatment of Severe Chloroquine Poisoning\uff0cN Engl J Med 1988; 318:1-6     DOI: 10.1056\/NEJM198801073180101<\/span><\/p>\n

[12]. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Res. 2020 Feb 4.   doi: 10.1038\/s41422-020-0282-0.<\/span><\/p>\n

[13]. \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8bca\u7597\u65b9\u6848(\u8bd5\u884c\u7b2c\u516d\u7248) \uff1a\u78f7\u9178\u6c2f\u55b9\u7247\uff1a\u6210\u4eba\u6bcf\u6b21500 mg\uff0c2\u6b21\/\u5929\uff0c\u7597\u7a0b10 \u5929\u3002<\/span><\/p>\n

[14]. Julie Ducharme J Farinotti R Clinical Pharmacokinetics and Metabolism of Chloroquine Clinical Pharmacokinetics volume 31, pages257\u2013274(1996)<\/span><\/p>\n

[15]. Fox RI. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Semin Arthritis Rheum. 1993 Oct;23(2 Suppl 1):82-91.<\/span><\/p>\n

[16]. Thomas J. Stokkermans; Georgios Trichonas. Chloroquine And Hydroxychloroquine Toxicity June 4, 2019. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.<\/span><\/p>\n

[17]. \u6c2f\u55b9\u8bf4\u660e\u4e66\uff08\u533b\u8109\u901a\uff09\uff1ahttp:\/\/drugs.medlive.cn\/drugref\/html\/20397.shtml<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u81ea\u65b0\u51a0\u75c5\u6bd2\u80ba\u708e\u75ab\u60c5\u5728\u6b66\u6c49\u548c\u6e56\u5317\u7206\u53d1\u4ee5\u6765\uff0c\u56fd\u5bb6\u79d1\u6280\u90e8\u9009\u5b9a\u4e86 100 \u4e2a\u5de6\u53f3\u7684\u836f\u7269\u5728\u52a8\u7269\u4f53\u5185\u5f00\u5c55\u6297\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u6d3b […]<\/p>\n","protected":false},"author":1,"featured_media":134828,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/134827"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=134827"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/134827\/revisions"}],"predecessor-version":[{"id":134833,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/134827\/revisions\/134833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/134828"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=134827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=134827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=134827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}