{"id":134966,"date":"2020-03-09T04:24:29","date_gmt":"2020-04-21T03:37:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/134966\/"},"modified":"2020-04-21T11:37:12","modified_gmt":"2020-04-21T03:37:12","slug":"631a3778f1","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/134966\/","title":{"rendered":"\u8f70\u8f70\u70c8\u70c8\u7684\u65b0\u51a0\u75ab\u82d7\u300c\u7814\u53d1\u6210\u529f\u300d\u70ed\u6f6e\uff0c\u4f1a\u6210\u4e3a\u753b\u997c\u5145\u9965\u7684\u5c34\u5c2c\u5417\uff1f"},"content":{"rendered":"
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<\/p>\n

\u5728\u7d2f\u8ba1\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\uff0c\u5145\u5206\u8bc1\u5b9e\u75ab\u82d7\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u3001\u7a33\u5b9a\u6027\u540e\uff0c\u8fd9\u79cd\u65b0\u75ab\u82d7\u624d\u80fd\u7533\u8bf7\u5ba1\u6279\u6ce8\u518c\uff0c\u6700\u540e\u6295\u5165\u751f\u4ea7\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e00\u8fc7\u7a0b\u770b\u4f3c\u7b80\u5355\uff0c\u4e8b\u5b9e\u4e0a\u975e\u5e38\u7e41\u6742\u548c\u6f2b\u957f\u3002<\/span>\u4ee5\u57c3\u535a\u62c9\u75c5\u6bd2\u75ab\u82d7\u7814\u53d1\u4e3a\u4f8b\uff0c<\/span>2014 \u5e74\uff0c<\/span>\u897f\u975e\u7206\u53d1\u4e25\u91cd\u57c3\u535a\u62c9\u75ab\u60c5\uff0c\u4e24\u5e74\u540e\uff0c\u5168\u7403\u9996\u6b3e\u6709\u6548\u9884\u9632\u57c3\u535a\u62c9\u75c5\u6bd2\u75ab\u82d7\u7814\u53d1\u7531\u52a0\u62ff\u5927\u7684\u7814\u7a76\u4eba\u5458\u7814\u53d1\u6210\u529f\u3002\u76f4\u5230 2019 \u5e74 11 \u6708\uff0c\u8be5\u75ab\u82d7\u624d\u83b7\u5f97\u6b27\u76df\u59d4\u5458\u4f1a\u6709\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\uff0c\u6b64\u65f6\u8ddd\u79bb\u75ab\u60c5\u7206\u53d1\u5df2\u7ecf\u8fc7\u53bb\u4e94\u5e74\u3002<\/span><\/span><\/section>\n
<\/span><\/section>\n
<\/span><\/section>\n

<\/span><\/section>\n
\u518d\u770b\u770b\u540c\u6837\u5c5e\u4e8e\u51a0\u72b6\u75c5\u6bd2\u5bb6\u65cf\u3001\u4e0e\u65b0\u51a0\u75c5\u6bd2\u6bd2\u682a<\/span>\u76f8\u4f3c\u6027<\/span>\u8f83\u9ad8\u7684<\/span> SARS\uff082003 \u5e74\u7206\u53d1\uff09\u548c MERS\uff082012 \u5e74\u7206\u53d1<\/span>\uff09\uff0c\u5230\u76ee\u524d\u4e3a\u6b62<\/span>\u90fd\u8fd8\u6ca1\u6709\u76f8\u5e94\u75ab\u82d7\u7814\u53d1\u95ee\u4e16\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/section>\n
\u4e00\u822c\u6765\u8bf4\uff0c\u4e00\u6b3e\u75ab\u82d7\u7684\u7814\u53d1\u9700\u8981 2\uff5e5 \u5e74\uff0c\u751a\u81f3\u66f4\u4e45\u3002<\/span>\u4f46\u5728\u67d0\u4e9b\u6781\u7aef\u60c5\u51b5\u4e0b\uff0c\u5982\u679c\u5168\u7403\u79d1\u7814\u673a\u6784\u7684\u7814\u53d1\u4eba\u5458\u901a\u529b\u5408\u4f5c\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u53ef\u80fd\u4f1a\u7f29\u77ed\uff0c\u6240\u4ee5\u4e16\u536b\u7ec4\u7ec7\u5728\u524d\u9762\u7684\u58f0\u660e\u4e2d\u7ed9\u51fa\u4e86\u300c18 \u4e2a\u6708\u53ca\u4ee5\u4e0a\u300d\u7684\u4f30\u8ba1\u65f6\u95f4\u3002<\/span><\/section>\n


<\/p>\n

\u4ece\u75ab\u60c5\u7206\u53d1\u5230\u73b0\u5728\u4ec5 3 \u6708\u4f59\uff0c\u5373\u4f7f\u6709\u75ab\u82d7\u7814\u53d1\u6210\u529f\uff0c\u4e5f\u8fd8\u53ea\u662f\u5728\u5b9e\u9a8c\u5ba4\u9636\u6bb5\uff0c\u6700\u7ec8\u95ee\u4e16\u5e76\u771f\u6b63\u5e94\u7528\u4e8e\u75ab\u60c5\u9632\u63a7\uff0c\u4ecd\u9700\u8981\u7b49\u5230\u6570\u6708\u4e43\u81f3\u6570\u5e74\u4ee5\u540e\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u516c\u5171\u536b\u751f\u5b66\u9662\u526f\u9662\u957f\u5f20\u4f5c\u98ce\u6559\u6388\u544a\u8bc9\uff0c\u300c\u4ece\u7406\u8bba\u4e0a\u6765\u8bb2\uff0c\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u5e94\u8be5\u81f3\u5c11\u8fd8\u8981\u7b49\u51e0\u4e2a\u6708\u7684\u65f6\u95f4\u3002\u6709\u4e9b\u784f\u7a76\u5355\u4f4d\u5927\u6982\u4ece 4 \u6708\u5f00\u59cb\u8fdb\u884c\u52a8\u7269\u5b9e\u9a8c\uff0c\u4e4b\u540e\u8fd8\u8981\u8fdb\u884c\u4eba\u4f53\u8bd5\u9a8c\uff0c\u6700\u5feb\u53ef\u80fd\u8981\u7b49\u5230 9 \u6708\u4efd\u3002\u300d<\/span><\/span><\/section>\n

<\/section>\n

<\/section>\n
mRNA \u75ab\u82d7\uff1a\u5b9e\u9645\u6548\u679c\u4ecd\u4e0d\u660e\u786e<\/strong><\/span><\/section>\n

<\/section>\n
\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u548c\u5373\u5c06\u5f00\u5c55\u7684\u75ab\u82d7\u7814\u53d1\uff0c\u4e3b\u8981\u662f\u96c6\u4e2d\u5728\u91cd\u7ec4\u86cb\u767d\u75ab\u82d7\u3001\u91cd\u7ec4\u817a\u75c5\u6bd2\u8f7d\u4f53\u75ab\u82d7\u3001mRNA \u75ab\u82d7\u548c\u706d\u6d3b\u75ab\u82d7\u8fd9\u51e0\u7c7b\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5176\u4e2d\uff0c<\/span>mRNA \u75ab\u82d7\u7b97\u662f\u4e00\u4e2a\u6bd4\u8f83\u65b0\u9896\u7684\u75ab\u82d7\u751f\u4ea7\u65b9\u6848\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u4e0e\u4f20\u7edf\u75ab\u82d7\u751f\u4ea7\u9700\u8981\u706d\u6d3b\u75c5\u6bd2\u6216\u91cd\u7ec4\u6297\u539f\u86cb\u767d\u4e0d\u540c\uff0c\u7531\u4e8e RNA \u5728\u751f\u7269\u4f53\u5185\u53ef\u4ee5\u8d1f\u8d23\u86cb\u767d\u8d28\u7684\u5408\u6210\uff0c\u7814\u7a76\u4eba\u5458\u53ea\u8981\u77e5\u9053\u75c5\u6bd2 RNA \u5e8f\u5217\uff0c\u5c31\u53ef\u4ee5\u76f4\u63a5\u5bf9 RNA \u8fdb\u884c\u4fee\u9970\u548c\u7f16\u8f91\uff0c\u8df3\u8fc7\u5408\u6210\u91cd\u7ec4\u86cb\u767d\u6216\u75c5\u6bd2\u7684\u6b65\u9aa4\uff0c\u76f4\u63a5\u5c06 RNA \u6ce8\u5c04\u5230\u4f53\u5185\uff0c\u8ba9\u4f53\u7ec6\u80de\u81ea\u8eab\u4ea7\u751f\u86cb\u767d\u6297\u539f\u3002<\/span><\/section>\n

<\/section>\n
Moderna \u7784\u51c6\u7684\u662f\u51a0\u72b6\u75c5\u6bd2\u4e0a\u7684 S \u86cb\u767d\uff08spike proteins\uff09\uff0c\u8be5\u86cb\u767d\u53ef\u4ee5\u4e0e\u7ec6\u80de\u8868\u9762 ACE2 \u53d7\u4f53\u7ed3\u5408\u5e76\u611f\u67d3\u7ec6\u80de\u3002Moderna \u7684\u7814\u53d1\u7b56\u7565\u662f\u5c06 S \u86cb\u767d\u7684 mRNA \u6307\u4ee4\u5305\u88c5\u6210\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff0c\u901a\u8fc7\u5c06\u7eb3\u7c73\u9897\u7c92\u6ce8\u5c04\u5230\u4eba\u7684\u808c\u8089\u4e2d\uff0c\u8ba9\u4eba\u4f53\u7ec6\u80de\u4ea7\u751f\u75c5\u6bd2\u86cb\u767d\u3002<\/span><\/section>\n

<\/section>\n
\u7406\u8bba\u4e0a\u6765\u8bf4\uff0c\u8fd9\u79cd\u65b9\u6cd5\u53ef<\/span>\u4ee5\u8ba9\u4eba\u4f53\u4ea7\u751f\u62b5\u6297<\/span>\u529b<\/span>\u3002\u8fdb\u5165\u4eba\u4f53\u7684 mRNA \u80fd\u591f\u8fdb\u4e00\u6b65\u6307\u5bfc\u6297\u539f\u86cb\u767d\u7684\u7ffb\u8bd1\uff0c\u6307\u5bfc\u5b8c\u6210\u540e\u5728\u4f53<\/span>\u5185\u964d\u89e3<\/span>\u3002<\/span><\/span>\u4f46<\/span>\u7406\u8bba\u6bd5\u7adf\u662f\u7406\u8bba\uff0c<\/span>mRNA \u75ab\u82d7\u6280\u672f\u65e9\u5728\u4e0a\u4e16\u7eaa 90 \u5e74\u4ee3\u5c31\u5df2\u7ecf\u51fa\u73b0\uff0c\u4e4b\u6240\u4ee5\u4e00\u76f4\u672a\u53d6\u4ee3\u4f20\u7edf\u75ab\u82d7\u5de5\u827a\uff0c\u662f\u56e0\u4e3a\u5b83\u975e\u5e38\u53d7\u5236\u4e8e\u6280\u672f\u3001mRNA \u672c\u8eab\u6027\u8d28\u7b49\u8bf8\u591a\u56e0\u7d20\u3002<\/span><\/section>\n

<\/section>\n
\u666e\u901a\u75ab\u82d7\uff08\u706d\u6d3b\u75c5\u6bd2\u6216\u6297\u539f\u86cb\u767d\u7b49\uff09\u4e00\u822c\u6bd4\u8f83\u7a33\u5b9a\uff0c\u53ef\u4ee5\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7684\u65b9\u5f0f\u5230\u8fbe\u4f53\u5185\uff0c\u4f46 mRNA \u672c\u8eab\u975e\u5e38\u4e0d\u7a33\u5b9a\uff0c\u5bb9\u6613\u964d\u89e3\u3002<\/strong><\/span><\/section>\n

<\/section>\n
\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u76ee\u524d\u5e38\u7528\u7684\u624b\u6bb5\u5c31\u662f Moderna \u8fd9\u79cd\u5229\u7528\u8102\u8d28\u4f53\u5305\u57cb\u7b49\u6280\u672f\u5c06 mRNA \u5236\u6210\u7eb3\u7c73\u9897\u7c92\uff0c\u901a\u8fc7\u808c\u8089\u6ce8\u5c04\u7b49\u6280\u672f<\/span>\u8fdb\u5165\u4eba\u4f53\u7684\u65b9\u5f0f\u3002<\/span>\u4f46<\/span>\u8fd9\u4e9b\u7eb3\u7c73\u9897\u7c92\u4ee5\u53ca\u5176\u4e2d\u7684 mRNA \u8fdb\u5165\u4eba\u4f53\u540e\u5230\u5e95\u4f1a\u4e0d\u4f1a\u6309\u7167\u4eba\u4eec<\/span>\u9884\u60f3\u7684\u90a3\u6837\u884c\u4f7f\u529f\u80fd\uff0c\u8fd8\u4e0d\u5f97\u800c\u77e5\u3002<\/span><\/section>\n

<\/section>\n
\u56e0\u6b64\uff0c\u867d\u7136\u5728\u75ab\u82d7\u7684\u7814\u7a76\u548c\u8bbe\u8ba1\u9636\u6bb5 mRNA \u75ab\u82d7\u80fd\u591f\u7f29\u77ed\u4e0d\u5c11\u65f6\u95f4\uff0c\u4f46\u5b9e\u9645\u6548\u679c\u4f9d\u7136\u4e0d\u5f97\u800c\u77e5\u3002<\/span>Moderna \u66fe\u4e8e 2019 \u5e74 8 \u6708\u6210\u529f\u5f00\u53d1\u5be8\u5361\u75c5\u6bd2\u75ab\u82d7\uff0c\u4ea7\u54c1\u4ee3\u53f7\u4e3a mRNA-1893\uff0c\u4f46\u81f3\u4eca\u4ecd\u672a\u4e0a\u5e02\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6b64\u5916\uff0c<\/span>\u76ee\u524d\u4e3a\u6b62\uff0c\u5168\u7403\u8fd8\u6ca1\u6709\u4e00\u6b3e mRNA \u75ab\u82d7\u4e0a\u5e02\u3002<\/span><\/section>\n
<\/strong><\/span><\/section>\n
\"\u8f70\u8f70\u70c8\u70c8\u7684\u65b0\u51a0\u75ab\u82d7\u300c\u7814\u53d1\u6210\u529f\u300d\u70ed\u6f6e\uff0c\u4f1a\u6210\u4e3a\u753b\u997c\u5145\u9965\u7684\u5c34\u5c2c\u5417\uff1f\"<\/section>\n
\"\u8f70\u8f70\u70c8\u70c8\u7684\u65b0\u51a0\u75ab\u82d7\u300c\u7814\u53d1\u6210\u529f\u300d\u70ed\u6f6e\uff0c\u4f1a\u6210\u4e3a\u753b\u997c\u5145\u9965\u7684\u5c34\u5c2c\u5417\uff1f\"<\/section>\n
Moderna \u516c\u53f8\u751f\u4ea7\u7ba1\u7ebf\u663e\u793a\u5176 RNA \u75ab\u82d7\u6240\u5904\u7814\u53d1\u9636\u6bb5\uff08Moderna \u516c\u53f8\u5b98\u7f51\uff09<\/span>
<\/section>\n

<\/section>\n
\u636e\u6089\uff0c\u516c\u53f8\u5c06\u5728 3\uff5e4 \u6708\u4efd\u5f00\u59cb\u5c0f\u89c4\u6a21\u4eba\u4f53\u8bd5\u9a8c\uff0c\u5982\u679c\u7ed3\u679c\u826f\u597d\uff0c\u5c06\u4f1a\u5728\u4e4b\u540e\u7684 6\uff5e8 \u6708\u65f6\u95f4\u5185\u5f00\u5c55\u5927\u89c4\u6a21\u4eba\u4f53\u8bd5\u9a8c\u3002<\/span>\u5373\u4f7f\u4e00\u5207\u987a\u5229\uff0c\u8be5\u75ab\u82d7\u6700\u7ec8\u95ee\u4e16\u4e5f\u8981\u7b49\u5230 12\uff5e<\/span>18 \u4e2a\u6708\u4ee5\u540e\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
MERS \u75ab\u82d7\u7ecf\u9a8c\u672a\u88ab\u9a8c\u8bc1\uff0c\u4f20\u7edf\u65b9\u6cd5\u96be\u4ee5\u7a81\u7834\u74f6\u9888<\/strong><\/strong><\/span><\/section>\n


<\/p>\n

\u9664\u4e86 mRNA \u75ab\u82d7\u601d\u8def\u5916\uff0cCEPI \u8d44\u52a9\u7684 Inovio \u548c\u6fb3\u5927\u5229\u4e9a\u6606\u58eb\u5170\u5927\u5b66\u6240\u5f00\u53d1\u51fa\u7684\u75ab\u82d7\u5219\u662f\u5728 MERS \u7684\u7814\u7a76\u57fa\u7840\u4e0a\uff0c\u52a0\u901f\u65b0\u51a0\u75ab\u82d7\u7684\u7814\u53d1\u901f\u5ea6\u3002<\/span><\/section>\n

<\/section>\n
Inovio \u6240\u7814\u53d1\u7684 MRES \u75ab\u82d7\u540d\u79f0\u4e3a INO4700\uff0c\u672c\u6b21\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u8bbe\u8ba1\u7684\u75ab\u82d7\u5219\u662f INO4800\uff0c\u4e8c\u8005\u90fd\u5c5e\u4e8e DNA \u75ab\u82d7\u3002\u8be5\u516c\u53f8\u6839\u636e MERS \u7684\u7814\u7a76\u7ecf\u9a8c\u5efa\u7acb\u4e86\u4e00\u4e2a\u5feb\u901f\u7814\u53d1\u5e73\u53f0\uff0c\u6240\u4ee5\u624d\u5728\u6b64\u6b21\u75ab\u82d7\u7814\u53d1\u4e2d\u8fdb\u5c55\u5feb\u901f\u3002<\/span><\/section>\n

<\/section>\n
\u6606\u58eb\u5170\u5927\u5b66\u7684\u300c\u5206\u5b50\u94b3\u300d\u75ab\u82d7\uff0c\u672c\u8d28\u662f\u4e00\u79cd\u53ef\u7528\u4e8e\u7ef4\u6301\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u591a\u80bd\uff0c\u5176\u4e0e\u75c5\u6bd2\u86cb\u767d\u7ed3\u5408\u6240\u5f62\u6210\u7684\u5d4c\u5408\u591a\u80bd\u53ef\u4ee5\u88ab\u63d0\u7eaf\u5e76\u7528\u4e8e\u75ab\u82d7\u7684\u5feb\u901f\u5236\u5907\u3002\u8fd9\u9879\u6280\u672f\u6b64\u524d\u4e5f\u88ab\u5e94\u7528\u4e8e\u5bf9\u6d41\u611f\u3001\u57c3\u535a\u62c9\u3001MERS \u7b49\u75c5\u6bd2\u7684\u75ab\u82d7\u7814\u53d1\u4e0a\u3002<\/span><\/section>\n

<\/section>\n
\"\u8f70\u8f70\u70c8\u70c8\u7684\u65b0\u51a0\u75ab\u82d7\u300c\u7814\u53d1\u6210\u529f\u300d\u70ed\u6f6e\uff0c\u4f1a\u6210\u4e3a\u753b\u997c\u5145\u9965\u7684\u5c34\u5c2c\u5417\uff1f\"<\/section>\n
\u56fe\u6e90\uff1aThe University of Queensland, Australia<\/span>
<\/section>\n

<\/section>\n
\u7136\u800c\uff0c\u76ee\u524d\u5e76\u672a\u89c1\u5230\u5e94\u7528\u8be5\u9879\u6280\u672f\u4e0a\u5e02\u7684\u4f20\u67d3\u75c5\u75ab\u82d7<\/span>\uff0c\u5206\u5b50\u94b3\u6280\u672f\u662f\u5426\u53ef\u884c\u4ecd\u6709\u5f85\u9a8c\u8bc1\u3002<\/span><\/span>\u6b64\u5916\uff0c\u81f3\u4eca\u90fd\u6ca1\u6709 MERS \u75ab\u82d7\u7814\u53d1\u95ee\u4e16<\/span>\uff0c\u8fd9\u4e24\u6b3e\u57fa\u4e8e MERS \u75ab\u82d7\u7814\u53d1\u7ecf\u9a8c\u6240\u5f00\u53d1\u7684\u65b0\u51a0\u75ab\u82d7\u80fd\u5426\u6709\u6548\uff0c\u8fd8\u9700\u8981\u6301\u8c28\u614e\u6001\u5ea6\u3002<\/span><\/section>\n

<\/section>\n
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<\/span><\/section>\n
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<\/span><\/span><\/p>\n


<\/section>\n
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<\/span><\/section>\n
\u53c2\u8003\u6765\u6e90\uff1a<\/span><\/section>\n
1.https:\/\/theconversation.com\/heres-why-the-who-says-a-coronavirus-vaccine-is-18-months-away-131213<\/span><\/section>\n
2.https:\/\/www.bbc.com\/news\/health-51665497<\/span><\/section>\n
3.https:\/\/www.statnews.com\/2020\/02\/26\/coronavirus-vaccines-are-far-off-fda-official-says-but-drugs-to-treat-patients-could-come-sooner\/<\/span><\/section>\n
4.Zhang, L., et al. (2020). “\u03b1-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.” Journal of Medicinal Chemistry.<\/span><\/section>\n
5.https:\/\/www.drugtargetreview.com\/news\/56607\/coronavirus-update-recent-developments-in-vaccine-research\/<\/span><\/section>\n
6.https:\/\/www.drugtargetreview.com\/news\/55371\/cepi-announces-three-programmes-to-develop-coronavirus-vaccine\/<\/span><\/section>\n
7.https:\/\/time.com\/5790545\/first-covid-19-vaccine\/<\/span><\/section>\n
8.https:\/\/nypost.com\/2020\/02\/28\/israeli-scientists-claim-to-be-weeks-away-from-coronavirus-vaccine\/<\/span><\/section>\n
9.https:\/\/www.nature.com\/articles\/nrd.2017.243<\/span><\/section>\n

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