{"id":135027,"date":"2020-03-09T12:00:50","date_gmt":"2020-04-21T03:37:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/135027\/"},"modified":"2020-04-21T11:37:41","modified_gmt":"2020-04-21T03:37:41","slug":"905a94edb8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/135027\/","title":{"rendered":"\u65b0\u51a0\u80ba\u708e\u5377\u8d77\u300c\u593a\u547d\u300d\u98ce\u66b4\uff0c\u8fd9\u4e2a\u79d8\u5bc6\u6b66\u5668\u5df2\u505a\u597d\u6218\u6597\u51c6\u5907"},"content":{"rendered":"
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1 \u6708 24 \u65e5\uff0cThe Lancet<\/em> \u53d1\u8868\u7684\u4e2d\u56fd\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u75c5\u4f8b\u9996\u6279\u4e34\u5e8a\u6570\u636e\u62a5\u544a\u6307\u51fa\uff0c\u5728\u5371\u91cd\u60a3\u8005\u4e2d\u53ef\u89c1\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u53d1\u751f [2]<\/sup>\u30022 \u6708 18 \u65e5\uff0cThe Lancet Respiratory Medicine<\/em> \u53c8\u53d1\u8868\u4e86\u5168\u7403\u9996\u4efd\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u75c5\u7406\u62a5\u544a [3]<\/sup>\u3002<\/span><\/p>\n

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\"\u65b0\u51a0\u80ba\u708e\u5377\u8d77\u300c\u593a\u547d\u300d\u98ce\u66b4\uff0c\u8fd9\u4e2a\u79d8\u5bc6\u6b66\u5668\u5df2\u505a\u597d\u6218\u6597\u51c6\u5907\"<\/section>\n<\/section>\n

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\u80ba\u90e8\u708e\u75c7\u9010\u6e10\u5438\u6536<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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2 \u6708 13 \u65e5\uff0c\u636e\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\u663e\u793a\uff0c\u300c\u6258\u73e0\u5355\u6297\u5728\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e (COVID-19) \u4e2d\u7684\u6709\u6548\u6027\u53ca\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u300d\u5df2\u7ecf\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\uff08\u6ce8\u518c\u53f7\uff1aChiCTR2000029765\uff09\u3002\u8be5\u9879\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u6258\u73e0\u5355\u6297\u6cbb\u7597\u666e\u901a\u578b NCP\uff08\u542b\u91cd\u75c7\u9ad8\u5371\u56e0\u7d20\uff09\u53ca\u91cd\u578b NCP \u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u7eb3\u5165 184 \u4f8b\u786e\u8bca\u4e3a\u65b0\u51a0\u80ba\u708e\u7684\u666e\u901a\u578b\u60a3\u8005\uff08\u542b\u91cd\u75c7\u9ad8\u5371\u56e0\u7d20\uff09\u3001\u91cd\u75c7\u578b\u60a3\u8005\uff0c\u60a3\u8005\u5e74\u9f84 18\uff5e85 \u5468\u5c81\uff0cIL-6 \u68c0\u6d4b\u5347\u9ad8<\/strong>\u3002\u5728\u6cbb\u7597\u65b9\u6848\u7684\u8bbe\u5b9a\u4e0a\uff0c\u6258\u73e0\u5355\u6297\u7684\u4f7f\u7528\u6ce8\u91cd 2 \u6761\u539f\u5219\uff1a<\/span><\/p>\n

\u65e9\u671f\u4f7f\u7528<\/strong><\/span><\/p>\n

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\u8db3\u91cf\u4f7f\u7528<\/strong><\/span><\/p>\n

\u9996\u6b21\u5242\u91cf 4\uff5e8 mg\/kg\uff0c\u63a8\u8350\u5242\u91cf 400 mg\uff0c\u52a0\u5165 100 ml \u751f\u7406\u76d0\u6c34\u8f93\u6ce8\u3002\u53d1\u70ed\u60a3\u8005\u5982\u9996\u6b21\u5e94\u7528 24 \u5c0f\u65f6\u4ecd\u6709\u53d1\u70ed\uff0c\u518d\u8ffd\u52a0\u5e94\u7528 1 \u6b21\uff08\u5242\u91cf\u540c\u524d\uff09\uff0c\u4e24\u6b21\u7528\u836f\u95f4\u9694 \u2265 12 \u5c0f\u65f6\uff0c\u7d2f\u8ba1\u7ed9\u836f\u6b21\u6570\u6700\u591a 2 \u6b21\u3002<\/span><\/p>\n

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\u6b64\u65f6\u6309\u7167 4\uff5e8 mg\/kg \u8db3\u91cf\u5730\u5e94\u7528\u6258\u73e0\u5355\u6297\uff0c\u4e5f\u80fd\u53d6\u5f97\u5f88\u597d\u7684\u7597\u6548\uff0c\u5b89\u5168\u6027\u826f\u597d\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6258\u73e0\u5355\u6297\u4ec5\u6291\u5236 IL-6 \u901a\u8def\u7684\u8fc7\u5ea6\u6fc0\u6d3b\uff0c\u4e0d\u5f71\u54cd\u5176\u4ed6\u53c2\u4e0e\u6297\u75c5\u6bd2\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u56e0\u6b64\u533a\u522b\u4e8e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5bf9\u7ec6\u80de\u514d\u75ab\u3001\u4f53\u6db2\u514d\u75ab\u7684\u5168\u9762\u6291\u5236\u4f5c\u7528\uff0c\u5b89\u5168\u6027\u66f4\u597d<\/strong>\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e
1. \u5f20\u6d77\u7965, \u7b49. \u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u5728\u6d41\u884c\u6027\u611f\u5192\u75c5\u6bd2\u611f\u67d3\u4e2d\u7684\u4f5c\u7528\u53ca\u9632\u6cbb\u7814\u7a76. \u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7. 2013(5):112-115.
2. Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.
3. Xu Z, et al. (2020). Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020. pii: S2213-2600(20)30076-X.
4. \u5f20\u8273\u4e3d, \u848b\u6f84\u5b87. \u7ec6\u80de\u56e0\u5b50\u98ce\u66b4: \u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\u4e2d\u7684\u4e3b\u5bb0\u751f\u547d\u4e4b\u624b. \u751f\u547d\u79d1\u5b66; 2015:27(05):44-47.
5. Wan S, et al. Characteristics of lymphocytesubsets and cytokines in peripheral blood of 123 hospitalized patients with2019 novel coronavirus pneumonia (NCP). medRxiv. 2020: p.2020.02.10.20021832.
6. Zhou Y, et al. Aberrant pathogenic GM-CSF+T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus. BioRxiv. 2020: p. 2020.02.12.945576.
7. \u56fd\u5bb6\u536b\u5efa\u59d4. \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u4e03\u7248\uff09. 2020.<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u8d23\u4efb\u7f16\u8f91\uff1a\u5218\u6654\u3001\u5b54\u5b87\u68ee
\u5c01\u9762\u53ca\u914d\u56fe\u6765\u6e90\uff1a\u7ad9\u9177\u6d77\u6d1b\u3001\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\u7f51\u7ad9<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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