{"id":135098,"date":"2020-03-10T12:43:47","date_gmt":"2020-04-21T03:38:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/135098\/"},"modified":"2020-04-21T11:38:22","modified_gmt":"2020-04-21T03:38:22","slug":"fccfde19b6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/135098\/","title":{"rendered":"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c 2 \u4f8b HIV \u6cbb\u6108\u6848\u4f8b"},"content":{"rendered":"
\n
2020 \u5e74 3 \u6708 10 \u65e5\uff0cRavindra K. Gupta \u56e2\u961f\u5728 Lancet HIV<\/em> \u53d1\u8868\u9898\u4e3a Evidence for HIV-1 cure after CCR5\u039432\/\u039432 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report<\/em> \u7684\u7814\u7a76 <\/span>[2]<\/span>\uff0c\u8ddf\u8fdb\u4e86\u53bb\u5e74\u90a3\u4f4d\u795e\u5947\u7684\u300c\u4f26\u6566\u75c5\u4eba\u300d\u6cbb\u7597\u6700\u65b0\u8fdb\u5c55\u3002<\/span><\/section>\n

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\u5728\u8fd9\u9879\u6700\u65b0\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u5bf9\u60a3\u8005\u75c5\u60c5\u6539\u5584\u7684\u8bc4\u4f30\u4ece\u300c\u957f\u671f\u7f13\u89e3\u300d\u6539\u4e3a\u4e86\u300c\u6cbb\u6108\u300d\uff0c\u5e76\u786e\u8ba4 \u300c\u4f26\u6566\u75c5\u4eba\u300d\u662f\u4e16\u754c\u4e0a\u7b2c 2 \u4f8b\u88ab\u6cbb\u6108\u7684\u827e\u6ecb\u75c5\u60a3\u8005\u3002<\/span><\/strong><\/span><\/section>\n

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\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/p>\n

\u56fe\u6e90\uff1aLancet HIV<\/em>
<\/span><\/p>\n


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<\/section>\n
\u300c\u67cf\u6797\u75c5\u4eba\u300d\u4e0d\u518d\u5b64\u5355<\/strong><\/span><\/section>\n

<\/section>\n
1995 \u5e74\uff0c\u4e00\u4f4d\u540d\u53eb\u8482\u83ab\u897f\u30fb\u96f7\u30fb\u5e03\u6717\uff08Timothy Ray Brown\uff09\u7684\u7537\u6027\u88ab\u786e\u8bca\u60a3\u4e0a\u827e\u6ecb\u75c5\u3002\u8270\u96be\u6c42\u751f\u5341\u4e00\u5e74\u540e\uff0c\u53ef\u601c\u7684\u5e03\u6717\u518d\u88ab\u786e\u8bca\u4e3a\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08Acute myeloid leukemia\uff0cAML\uff09\uff0c\u6b7b\u795e\u7684\u9570\u5200\u7ec8\u4e8e\u6325\u5411\u4e86\u8fd9\u4f4d\u82df\u5ef6\u6b8b\u5598\u7684\u827e\u6ecb\u75c5\u75c5\u4eba\u3002<\/span><\/section>\n

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\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

\u5728\u8857\u5934\u5fae\u7b11\u7684\u4e50\u89c2\u7684 Timothy<\/span><\/p>\n


<\/section>\n
\u4f46\u5e03\u6717\u548c\u4ed6\u7684\u533b\u751f\u5e76\u6ca1\u675f\u624b\u5c31\u64d2\uff0c\u6765\u81ea\u67cf\u6797\u7684\u533b\u751f Gero H\u00fctter \u51b3\u5b9a\u8fdb\u884c\u4e00\u6b21\u5927\u80c6\u7684\u6cbb\u7597\uff0c\u4ed6\u4ece 60 \u540d\u9aa8\u9ad3\u6350\u8d60\u8005\u4e2d\u6311\u9009\u51fa\u4e00\u540d\u7279\u6b8a\u7684\u6350\u8d60\u8005\uff0c\u8fd9\u540d\u6350\u8d60\u8005\u643a\u5e26 CCR5-\u039432 \u7a81\u53d8\u3002<\/span><\/section>\n

<\/section>\n
CCR5 \u6b64\u524d\u88ab\u73b0\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u6559\u6388\u8bc1\u660e\u662f HIV \u75c5\u6bd2\u4fb5\u5165 \u03a4 \u7ec6\u80de\u7684\u4e3b\u8981\u53d7\u4f53\u3002\u6709 1% \u7684\u6b27\u6d32\u4eba\u5929\u751f\u643a\u5e26 CCR5-\u039432 \u7684\u7a81\u53d8\u3002\u540e\u6765\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u79cd\u7a81\u53d8\u8ba9\u4ed6\u4eec\u5148\u5929\u5bf9 CCR5 (R5) \u55dc\u6027 HIV \u75c5\u6bd2\u514d\u75ab\u3002<\/span><\/section>\n

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<\/span><\/span><\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

\u9093\u5b8f\u9b41\u6559\u6388\u6b64\u524d<\/span>\u76f8\u5173\u8bba\u6587\uff0c\u56fe<\/span>\u6e90\uff1a<\/span>Nature<\/em>
<\/p>\n


<\/section>\n
\u5e03\u6717\u7684\u9aa8\u9ad3\u79fb\u690d\u624b\u672f\u975e\u5e38\u6210\u529f\uff0c\u4ed6\u7684\u767d\u8840\u75c5\u4e5f\u968f\u5373\u75ca\u6108\u3002\u66f4\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u4ed6\u4f53\u5185\u7684 \u0397\u0399V \u75c5\u6bd2\u4e0b\u964d\u5230\u4e86\u68c0\u6d4b\u4e0d\u5230\u7684\u6c34\u5e73\uff0c\u4e5f\u65e0\u9700\u518d\u670d\u7528\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08ART\uff09\u6765\u6291\u5236 \u0397\u0399V \u75c5\u6bd2\uff0c\u5e03\u6717\u4e5f\u5b58\u6d3b\u81f3\u4eca\u3002<\/span><\/section>\n

<\/section>\n
\u5728 2019 \u5e74 3 \u6708 8 \u53f7\u4ee5\u524d\uff0c\u5e03\u6717\u88ab\u8ba4\u4e3a\u662f\u4e16\u754c\u4e0a\u7b2c\u4e00\u4f4d\u4e5f\u662f\u552f\u4e00\u4e00\u4f4d\u88ab\u6cbb\u6108\u7684\u827e\u6ecb\u75c5\u60a3\u8005\uff0c\u4e5f\u56e0\u6b64\u88ab\u79f0\u4e3a\u300c\u67cf\u6797\u75c5\u4eba\u300d\u3002<\/span><\/strong><\/span><\/section>\n

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\u53bb\u5e74 3 \u6708 8 \u53f7\uff0c\u5251\u6865\u5927\u5b66\u7684 Ravindra K. Gupta \u6559\u6388\u5e26\u9886\u56e2\u961f\u5728 Nature<\/em> \u53d1\u8868\u4e86\u9898\u4e3a HIV-1 remission following CCR5\u039432\/\u039432 haematopoietic stem-cell transplantation<\/strong> \u7684\u8bba\u6587<\/span> [1]<\/span>\uff0c\u8ba9\u5b64\u72ec\u7684\u67cf\u6797\u60a3\u8005\u6709\u4e86\u966a\u4f34\u3002<\/span><\/section>\n

<\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

\u56fe\u6e90\uff1aNature<\/em><\/span><\/p>\n


<\/section>\n
\u6587\u7ae0\u62a5\u9053\u82f1\u56fd\u4f26\u6566\u4e00\u4f4d\u540c\u65f6\u60a3\u6709\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u827e\u6ecb\u75c5\u7684\u75c5\u4eba\u5728\u63a5\u53d7\u6765\u6e90\u4e8e CCR5-\u039432 \u6350\u8d60\u8005\u7684\u9020\u8840\u79fb\u690d\u540e\u7684 16 \u4e2a\u6708\u5185\uff0c\u4e0d\u4ec5\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u5eb7\u590d\u4e86\uff0c\u60a3\u8005\u8840\u6db2\u5185\u4e5f\u6ca1\u6709\u518d\u53d1\u73b0\u827e\u6ecb\u75c5\u75c5\u6bd2\u3002<\/span><\/section>\n

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\u968f\u540e\u8be5\u60a3\u8005\u8fdb\u884c\u4e86\u505c\u6b62\u670d\u7528 \u0391RT \u836f\u7269 18 \u4e2a\u6708\uff0c\u5728\u8bba\u6587\u6295\u7a3f\u524d\u8840\u6db2\u5185\u4e5f\u6ca1\u6709\u53d1\u73b0\u827e\u6ecb\u75c5\u75c5\u6bd2\u3002\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8fd9\u4f4d\u300c\u4f26\u6566\u75c5\u4eba\u300d\u7684\u827e\u6ecb\u75c5\u5f97\u5230\u4e86\u300c\u957f\u671f\u7f13\u89e3\u300d\uff0c\u4ed6\u5f88\u6709\u53ef\u80fd\u6210\u4e3a\u827e\u6ecb\u75c5\u88ab\u6cbb\u6108\u7684\u7b2c\u4e8c\u4f8b\u60a3\u8005\u3002<\/span><\/section>\n

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\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c\u65f6\u9694\u4e00\u5e74\uff0c\u300c\u4f26\u6566\u75c5\u4eba\u300d\u6700\u7ec8\u88ab\u786e\u8ba4\u4e3a\u4e16\u754c\u4e0a\u7b2c 2 \u4f8b\u88ab\u6cbb\u6108\u7684\u827e\u6ecb\u75c5\u60a3\u8005\u3002<\/span><\/strong><\/span><\/section>\n

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\u300c\u4f26\u6566\u75c5\u4eba\u300d\u7528 30 \u4e2a\u6708\u91cd\u73b0\u5947\u8ff9<\/strong><\/span><\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

\u56fe\u6e90\uff1aLancet HIV<\/em><\/span><\/p>\n


<\/section>\n
\u5728\u6b64\u524d Nature<\/em> \u7684\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53ea\u62a5\u9053\u4e86\u505c\u6b62\u670d\u7528 ART \u836f\u7269\u540e 18 \u4e2a\u6708\u8840\u6d46\u4e2d\u7684 HIV \u75c5\u6bd2\u8f7d\u91cf\u3002\u672c\u6b21\u6587\u7ae0\u8ddf\u8fdb\u62a5\u9053\u4e86 19 \u5e74 3 \u6708\u5230 20 \u5e74 3 \u6708\u4e4b\u95f4\u7684\u8fdb\u5c55\uff0c\u5c06\u65f6\u95f4\u5ef6\u957f\u5230\u4e86 30 \u4e2a\u6708\u3002<\/span><\/section>\n

<\/section>\n
\u5728\u65b0\u589e\u7684 12 \u4e2a\u6708\u671f\u95f4\uff0c\u8840\u6d46\u4e2d HIV \u75c5\u6bd2\u8f7d\u91cf\u4f9d\u65e7\u4f4e\u4e8e\u68c0\u6d4b\u9650\u800c\u65e0\u6cd5\u88ab\u68c0\u6d4b\u5230\u3002\u79fb\u690d\u9020\u8840\u5f62\u6210\u7684\u5d4c\u5408\u73b0\u8c61\u4f9d\u7136\u53ef\u4ee5\u8fbe\u5230 99% \u7684\u6bd4\u4f8b\uff1b\u60a3\u8005\u7684 CD4 \u7ec6\u80de\u6570\u4e5f\u6062\u590d\u5230\u6b63\u5e38\u6c34\u5e73\u3002<\/span><\/section>\n

<\/section>\n
\u60a3\u8005\u5728\u8fd9\u671f\u95f4\u4f53\u5185\u4f9d\u65e7\u51fa\u73b0\u4e86\u548c Nature \u62a5\u9053\u4e2d\u4e00\u6837\u7684\u7b2c\u56db\u578b\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd2\uff08Epstein\u2013Barr virus\uff0cEBV) \u548c\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08Cytomegalovirus\uff0cCMV\uff09\uff0c\u4f46 CMV \u75c5\u6bd2\u8f7d\u91cf\u5728\u79fb\u690d 18 \u6708\u540e\u964d\u4f4e\u3002<\/span><\/section>\n

<\/section>\n
\u60a3\u8005\u5728\u8fd9\u671f\u95f4\u6ca1\u6709\u670d\u7528\u514d\u75ab\u6291\u5236\u836f\u7269\uff0c\u5e76\u6ca1\u6709\u51fa\u73b0\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u53cd\u5e94\uff08graft versus host disease\uff09\u3002<\/span>\u5fae\u6ef4\u6570\u5b57 PCR\uff08Droplet Digital PCR\uff09\u663e\u793a CD4 T \u7ec6\u80de\u4e2d\u65e0\u6cd5\u68c0\u51fa HIV1 \u524d\u75c5\u6bd2\u7684\u957f\u672b\u7aef\u91cd\u590d\u5e8f\u5217\uff08HIV-1 LTR\uff09\uff0c\u4f46\u5728\u8bb0\u5fc6 T \u7ec6\u80de\u4e2d\u68c0\u6d4b\u5230\u5c11\u91cf\u7684 HIV-1 LTR\u3002<\/span><\/span><\/section>\n

<\/section>\n
\u5728 Nature <\/em>\u7814\u7a76\u4e2d\u68c0\u6d4b\u8840\u6d46\u7684\u57fa\u7840\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u5728\u6b64\u6b21\u7814\u7a76\u4e2d\u7279\u610f\u68c0\u6d4b\u4e86\u591a\u4e2a HIV \u6f5c\u4f0f\u5e93\u4e2d\u662f\u5426\u5b58\u5728 HIV \u75c5\u6bd2\u3002\u7cbe\u6db2\u3001\u8111\u810a\u6db2\u548c\u7a7f\u523a\u7ec4\u7ec7\u6d3b\u68c0\u4e2d HIV \u75c5\u6bd2\u8f7d\u91cf\u90fd\u4f4e\u4e8e\u68c0\u6d4b\u9650\uff0c\u5448\u73b0\u9634\u6027\u3002<\/span><\/section>\n

<\/section>\n
\u6dcb\u5df4\u7ed3\u4e2d\u68c0\u51fa\u5c11\u91cf HIV \u819c\u7cd6\u86cb\u767d\u57fa\u56e0\uff08env\uff09\u3001LRT \u548c\u7ed3\u6784\u86cb\u767d\u57fa\u56e0\uff08gag\uff09\uff0c\u4f46\u6ca1\u6709\u68c0\u6d4b\u5230\u7684 DNA \u6574\u5408\u9176\uff0c\u8bc1\u660e HIV \u57fa\u56e0\u7ec4\u542b\u91cf\u4f4e\u4e14\u4e0d\u5b8c\u6574\u3002RT-PCR \u4e5f\u663e\u793a\u51fa\u76f8\u4f3c\u7684\u7ed3\u679c\uff0c\u540c\u65f6\u8bc1\u660e\u4e86 HIV \u5305\u88c5\u4fe1\u53f7 \u03c8 \u7684\u7f3a\u5931\u3002\u8fd9\u610f\u5473\u7740\u8fd9\u4e9b\u5c11\u91cf\u7684 HIV \u57fa\u56e0\u4e0d\u8db3\u4ee5\u5bfc\u81f4 HIV \u590d\u53d1\u3002<\/span><\/section>\n

<\/section>\n

\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/p>\n

\u56fe\u6e90\uff1aLancet HIV<\/em><\/span><\/p>\n


<\/section>\n
\u7814\u7a76\u4eba\u5458\u968f\u540e\u68c0\u6d4b\u4e86\u60a3\u8005\u4f53\u5185 CD4 \u548c CD8 T \u7ec6\u80de\u5bf9 HIV gag, EBV \u548c CMV \u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u3002\u53d1\u73b0\u60a3\u8005\u7684 T \u7ec6\u80de\u53ea\u5bf9 EBV \u548c CMV \u4ea7\u751f\u514d\u75ab\u5e94\u7b54\uff0c\u800c\u5bf9 HIV gag \u65e0\u54cd\u5e94\u3002<\/span><\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

\u56fe\u6e90\uff1aLancet HIV<\/em><\/span><\/p>\n


<\/section>\n
\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u5c3d\u7ba1\u60a3\u8005\u4f53\u5185\u4f9d\u65e7\u5b58\u5728\u4e00\u5b9a\u91cf\u7684 HIV \u6297\u4f53\uff0c\u4f46\u8fd9\u4e9b\u6297\u4f53\u4eb2\u548c\u529b\u51fa\u73b0\u4e86\u660e\u663e\u7684\u4e0b\u964d\uff0c\u8fd9\u4e9b\u8bc1\u636e\u4e00\u8d77\u8bc1\u660e\u4e86\u8be5\u60a3\u8005\u7684\u827e\u6ecb\u75c5\u5df2\u7ecf\u83b7\u5f97\u4e34\u5e8a\u6cbb\u6108\u3002<\/span><\/section>\n

<\/section>\n

\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/p>\n

\u56fe\u6e90\uff1aLancet HIV<\/em><\/span><\/p>\n


<\/section>\n
\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u6570\u5b66\u6a21\u578b\u5bf9\u60a3\u8005\u7f13\u548c\u7684\u6982\u7387\u8fdb\u884c\u6a21\u62df\uff0c\u8ba4\u4e3a\u5728 90% \u5d4c\u5408\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u300c\u957f\u671f\u7f13\u89e3\u300d\u7684\u6982\u7387\u9ad8\u4e8e 99%\u3002\u800c\u76ee\u524d\u8be5\u60a3\u8005\u5d4c\u5408\u7387\u957f\u65f6\u95f4\u7a33\u5b9a\u5728 99%\uff0c\u4f5c\u8005\u6839\u636e\u6b64\u524d\u300c\u67cf\u6797\u75c5\u4eba\u300d\u7684\u6cbb\u7597\u53f2\u8ba4\u4e3a\uff0c\u300c\u4f26\u6566\u75c5\u4eba\u300d\u7684\u827e\u6ecb\u75c5\u5df2\u7ecf\u88ab\u6cbb\u6108\u3002<\/span><\/section>\n

<\/section>\n
\u8be5\u8bba\u6587\u518d\u6b21\u8bc1\u660e\u4e86\u5229\u7528 CCR5 \u7a81\u53d8\u7684\u9020\u8840\u79fb\u690d\u6cbb\u7597\u827e\u6ecb\u75c5\u7684\u53ef\u80fd\uff0c\u4e5f\u4e3a\u4eca\u540e\u76f8\u5173\u7597\u6cd5\u7684\u4e34\u5e8a\u5b9e\u65bd\u63d0\u4f9b\u4e86\u7ecf\u9a8c\u548c\u6307\u5f15\u3002<\/span><\/section>\n

<\/section>\n
\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5728 HIV \u75ab\u82d7\u548c\u836f\u7269\u7814\u7a76\u5c61\u8d25\u5c61\u6218\u7684\u4eca\u5929\uff0c\u300c\u67cf\u6797\u75c5\u4eba\u300d\u7684\u5947\u8ff9\u88ab\u300c\u4f26\u6566\u75c5\u4eba\u300d\u91cd\u73b0\uff0c\u7ed9\u4e86\u5168\u4e16\u754c 3800 \u4e07\u827e\u6ecb\u75c5\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
CCR5 \u7684\u6545\u4e8b\u4ecd\u5728\u7ee7\u7eed<\/strong><\/span><\/section>\n

<\/section>\n
\u7531\u4e8e\u827e\u6ecb\u75c5\u76ee\u524d\u6682\u65f6\u6ca1\u6709\u6709\u6548\u6cbb\u6108\u65b9\u6cd5\uff0c\u4eba\u4eec\u5bf9\u827e\u6ecb\u75c5\u7684\u770b\u6cd5\u5df2\u7ecf\u5230\u4e86\u8c08\u300c\u827e\u300d\u8272\u53d8\u7684\u5730\u6b65\u3002\u6bcf\u6b21\u5173\u4e8e\u827e\u6ecb\u75c5\u7684\u8fdb\u5c55\u90fd\u80fd\u5728\u5b66\u672f\u754c\u5185\u5916\u5f15\u53d1\u70ed\u70c8\u7684\u8ba8\u8bba\uff0c\u8fd1\u51e0\u5e74\u6765\u5173\u4e8e CCR5 \u7684\u6545\u4e8b\u66f4\u662f\u8dcc\u5b95\u8d77\u4f0f\u3002<\/span><\/section>\n

<\/section>\n
\u5728\u300c\u4f26\u6566\u75c5\u4eba\u300d\u88ab\u62a5\u9053\u4e4b\u524d\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u8d3a\u5efa\u594e\u6559\u6388\u5c31\u4f7f\u7528\u4e86\u5982\u65e5\u4e2d\u5929\u7684 CRISPR \u6280\u672f\u5bf9\u827e\u6ecb\u75c5\u60a3\u8005\u7684\u80ce\u513f\u8fdb\u884c\u4e86\u57fa\u56e0\u7f16\u8f91\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u4ed6\u6572\u9664\u4e86\u5a74\u513f\u4f53\u5185 CCR5 \u4ee5\u8ba9\u5a74\u513f\u83b7\u5f97\u7c7b\u4f3c\u4e8e\u300c\u67cf\u6797\u75c5\u4eba\u300d\u548c CCR5-\u039432 \u7a81\u53d8\u643a\u5e26\u8005\u4e00\u6837\u7684\u827e\u6ecb\u75c5\u514d\u75ab\u3002\u53ef\u4ed6\u5192\u8fdb\u7684\u884c\u4e3a\u56e0\u4e3a\u4f26\u7406\u5b66\u4e89\u8bae\u548c\u4f2a\u9020\u5b9e\u9a8c\u4f26\u7406\u5ba1\u6279\u624b\u7eed\u5f15\u53d1\u4e86\u4e16\u754c\u79d1\u5b66\u754c\u7684\u9707\u8361\u4ee5\u53ca\u6240\u6709\u79d1\u5b66\u5bb6\u7684\u58f0\u8ba8\u3002<\/span>\u53bb\u5e74\uff0c<\/span>\u8d3a\u5efa\u594e<\/span>\u56e0\u6b64\u88ab\u5224\u5165\u72f1\u4e09\u5e74\u3002<\/span><\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

\u56fe\u6e90\uff1aNature Medicine<\/em><\/span>
<\/p>\n


<\/section>\n
\u5728\u8d3a\u5efa\u594e\u4e8b\u4ef6\u548c\u300c\u4f26\u6566\u75c5\u4eba\u300d\u516c\u5e03\u4e4b\u540e\uff0c\u5b66\u754c\u5bf9 CCR5-\u039432 \u7a81\u53d8\u7684\u5b89\u5168\u6027\u5c55\u5f00\u4e86\u7814\u7a76\u3002<\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7684 Rasmus Nielsen \u548c Xinzhu Wei \u5728 Nature Medicine<\/em> \u53d1\u8868\u4e86\u9898\u4e3a CCR5-\u220632 is deleterious in the homozygous state in humans \u7684\u8bba\u6587<\/em><\/span> <\/span><\/span>[3]<\/span>\uff0c\u62a5\u9053 CCR5-\u220632 \u7eaf\u5408\u5b50\u4f1a\u5bfc\u81f4 21% \u7684\u5168\u56e0\u6b7b\u4ea1\u7387\u7684\u589e\u52a0\u3002\u8be5\u8bba\u6587\u5f15\u53d1\u70ed\u8bae\u540e\uff0c\u56e0\u4e3a\u6570\u636e\u548c\u5176\u4ed6\u7814\u7a76\u51b2\u7a81\u4e14\u5206\u6790\u65b9\u6cd5\u6709\u8bef\u6700\u7ec8\u88ab\u64a4\u7a3f\u3002<\/span><\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c
<\/section>\n

\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/p>\n

\u56fe\u6e90\uff1aNature Medicine<\/em><\/span>
<\/p>\n


<\/section>\n
\u620f\u5267\u6027\u7684\u662f\uff0c\u51e0\u6708\u540e\u5305\u62ec\u8be5\u6587\u539f\u4f5c\u8005\u5728\u5185\u7684\u7814\u7a76\u4eba\u5458\u5728\u91cd\u65b0\u5206\u6790\u6570\u636e\u540e\u518d\u6b21\u5728 Nature Medicine<\/em> \u53d1\u8868\u4e86\u9898\u4e3a No statistical evidence for an effect of CCR5-\u220632 on lifespan in the UK Biobank cohort<\/em> \u7684\u6587\u7ae0 <\/span>[4]<\/span>\uff0c\u58f0\u660e\u6ca1\u6709\u8bc1\u636e\u8868\u660e CCR5-\u220632 \u7a81\u53d8\u4f1a\u5f71\u54cd\u643a\u5e26\u8005\u7684\u5bff\u547d\uff0c\u4e3a\u76f8\u5173\u7814\u7a76\u626b\u6e05\u4e86\u90e8\u5206\u969c\u788d\u3002<\/span><\/section>\n
\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c
<\/section>\n
<\/span><\/span><\/section>\n

\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/p>\n

\u56fe\u6e90\uff1aNEJM<\/em><\/span>
<\/p>\n


<\/section>\n
\u9664\u4e86\u4f7f\u7528 CCR5-\u220632 \u7a81\u53d8\u643a\u5e26\u8005\u7684\u9020\u8840\uff0cCCR5 \u7684\u53d1\u73b0\u8005\uff0c\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u6559\u6388\u7684\u7814\u7a76\u7ec4\u3001\u89e3\u653e\u519b\u603b\u533b\u9662\u7b2c\u4e94\u533b\u5b66\u4e2d\u5fc3\u9648\u864e\u7814\u7a76\u7ec4\u53ca\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u4f51\u5b89\u533b\u9662\u5434\u660a\u7814\u7a76\u7ec4\u5408\u4f5c\uff0c\u5728 \u039d\u0395JM <\/em>\u53d1\u8868\u4e86\u9898\u4e3a CRISPR-Edited Stem s in a Patient with HIV and Acute Lymphocytic Leukemia <\/em><\/span>[5]<\/span> \u7684\u7814\u7a76\uff0c\u62a5\u9053\u4e86\u4f7f\u7528 CRISPR \u6280\u672f\u7f16\u8f91\u9020\u8840\u4e2d\u7684 CCR5 \u540e\u8fdb\u884c\u79fb\u690d\u4ee5\u89c4\u907f\u4f26\u7406\u5b66\u548c\u5b89\u5168\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u6709\u671b\u5c06\u300c\u67cf\u6797\u75c5\u4eba\u300d\u548c\u300c\u4f26\u6566\u75c5\u4eba\u300d\u91cf\u4ea7\uff0c\u5e2e\u52a9\u66f4\u591a\u7684\u827e\u6ecb\u75c5\u60a3\u8005\u3002\u5c3d\u7ba1\u7814\u7a76\u4e2d\u7684\u7f16\u8f91\u6548\u7387\u4e0d\u9ad8\uff0c\u4f46\u8be5\u6280\u672f\u7684\u5b89\u5168\u6027\u548c\u6f5c\u529b\u5df2\u7ecf\u5728\u7814\u7a76\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002<\/span><\/section>\n

<\/section>\n
\u672c\u6b21\u300c\u4f26\u6566\u75c5\u4eba\u300d\u88ab\u6cbb\u6108\u4e5f\u8fdb\u4e00\u6b65\u8bc1\u660e\uff0c\u9093\u5b8f\u9b41\u6559\u6388\u548c\u4e0d\u5e78\u75c5\u901d\u7684\u9648\u864e\u6559\u6388\u9009\u62e9\u7684\u9053\u8def\u662f\u6b63\u786e\u7684\u3002<\/span>\uff08\u8d23\u4efb\u7f16\u8f91\uff1aIvan\u3001dxylc\uff09<\/span><\/section>\n

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\u9898\u56fe\u6765\u6e90\uff1a\u56fe\u866b\u521b\u610f
<\/span><\/section>\n
\u53c2\u8003\u6765\u6e90\uff1a
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1.Gupta, R.K., et al., HIV-1 remission following CCR5\u039432\/\u039432 haematopoietic stem-cell transplantation. Nature, 2019. 568(7751): p. 244-248.<\/span><\/p>\n

2.Gupta, R.K., et al., Evidence for HIV-1 cure after CCR5\u039432\/\u039432 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report. Lancet HIV, 2020.<\/span><\/p>\n

3.Wei, X. and R. Nielsen, CCR5-\u220632 is deleterious in the homozygous state in humans. Nature Medicine, 2019. 25(6): p. 909-910.<\/span><\/p>\n

4.Maier, R., et al., No statistical evidence for an effect of CCR5-\u220632 on lifespan in the UK Biobank cohort. Nature Medicine, 2020. 26(2): p. 178-180.<\/span><\/p>\n

5.Xu, L., et al., CRISPR-Edited Stem s in a Patient with HIV and Acute Lymphocytic Leukemia. New England Journal of Medicine, 2019. 381(13): p. 1240-1247.<\/span><\/p>\n


<\/p>\n

\"\u91cd\u78c5\uff01\u67f3\u53f6\u5200\u6b63\u5f0f\u53d1\u6587\uff1a\u786e\u8ba4\u4e16\u754c\u4e0a\u7b2c<\/section>\n

<\/section>\n
\u2193\u2193\u2193 \u70b9\u51fb\u300c\u9605\u8bfb\u539f\u6587\u300d\u53ef\u67e5\u770b\u8bba\u6587\u539f\u6587<\/strong><\/section>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

2020 \u5e74 3 \u6708 10 \u65e5\uff0cRavindra K. Gupta \u56e2\u961f\u5728 Lancet HIV&n […]<\/p>\n","protected":false},"author":1,"featured_media":135099,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/135098"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=135098"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/135098\/revisions"}],"predecessor-version":[{"id":135118,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/135098\/revisions\/135118"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/135099"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=135098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=135098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=135098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}