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\u4f5c\u8005\uff1a<\/span>Teresa<\/span><\/p>\n

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\"\u3010\u56fd\u4eba\u798f\u97f3\u3011\u591a\u6b3e\u836f\u7269\u53ae\u6740\u809d\u75c5\u5927\u56fd\u6700\u540e\u7684\u7ea2\u5229\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u533b\u9662\u5904\u65b9\u5206\u6790\u7cfb\u7edf RAS<\/span><\/p>\n

\u4ece\u7814\u53d1\u5e03\u5c40\u4e0a\u770b\uff0c\u8fdb\u51652018\u5e74\uff0c\u6839\u636e\u4e2d\u56fd\u65b0\u836f\u7814\u53d1\u6570\u636e\u5e93CPM\u76d1\u6d4b\uff0c\u5305\u542b\u4eff\u5236\u836f\u548c\u539f\u7814\u836f\u5728\u5185\uff0c\u5171\u670917\u6761\u53d7\u7406\u4fe1\u606f\uff08\u9664\u53bb\u8865\u5145\u7533\u8bf7\uff09\uff0c\u6765\u81ea13\u4e2a\u4f01\u4e1a\uff1b\u800c\u6b63\u5927\u5929\u6674\u3001\u6c5f\u897f\u9752\u5cf0\u7b49\u56e0\u4e3a\u901a\u8fc7\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u800c\u6210\u4e3a\u5177\u6709\u5148\u53d1\u4f18\u52bf\u7684\u53d7\u76ca\u8005\u3002<\/span><\/p>\n

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\u6570\u636e\u6765\u6e90\uff1a\u533b\u9662\u5904\u65b9\u5206\u6790\u7cfb\u7edf RAS<\/span>
<\/p>\n

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\u6570\u636e\u6765\u6e90\uff1a\u533b\u9662\u5904\u65b9\u5206\u6790\u7cfb\u7edf RAS<\/span>
<\/p>\n

2018\u809d\u708e\u7528\u836f\u8fce\u6765\u65b0\u7a81\u7834\uff0c\u591a\u5bb6\u4f01\u4e1a\u7ade\u76f8\u4e89\u593a\u7ea2\u5229\u5e02\u573a<\/strong><\/span><\/p>\n

\u4e2d\u56fd\u9996\u4e2a\u672c\u571f\u539f\u7814\u6297\u4e19\u809d\u521b\u65b0\u836f\u83b7\u6279\u4e0a\u5e02<\/span><\/strong><\/p>\n

\u8fbe\u8bfa\u745e\u97e6\u94a0\u7247\uff0c\u6b4c\u793c6\u670813\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5f00\u53d1\u7684\u9996\u4e2a\u6297\u4e19\u809d1\u7c7b\u521b\u65b0\u836f\u6208\u8bfa\u536b\u00ae\uff08\u8fbe\u8bfa\u745e\u97e6\uff0cASC08\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\u3002\u6208\u8bfa\u536b\u00ae\u662f\u9996\u4e2a\u7531\u4e2d\u56fd\u672c\u571f\u4f01\u4e1a\u5f00\u53d1\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u836f\u7269\uff08Direct ActingAnti-viral agent, DAA\uff09\uff0c\u83b7\u5341\u4e09\u4e94\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u7acb\u9879\u652f\u6301\u3002\u5b83\u662f2018\u5e74\u4e0a\u534a\u5e74\u4ec5\u6709\u7684\u56db\u4e2a\u83b7\u6279\u4e00\u7c7b\u65b0\u836f\u4e4b\u4e00\u3002\u4f5c\u4e3a\u65b0\u4e00\u4ee3NS3\/4A\u86cb\u767d\u9176\u6291\u5236\u5242\uff0c\u6208\u8bfa\u536b\u00ae\u5728\u4e2d\u56fd\u53f0\u6e7e\u3001\u6b27\u7f8e\u3001\u6cf0\u56fd\u3001\u97e9\u56fd\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u5b8c\u6210\u4e86\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\u663e\u793a\uff1a\u5728\u57fa\u56e01\u578b\u809d\u786c\u5316\u60a3\u8005\u4e2d\u7684\u6cbb\u6108\u7387\u8fbe91%\uff1b\u5728\u57fa\u56e04\u578b\u975e\u809d\u786c\u5316\u60a3\u8005\u4e2d\u7684\u6cbb\u6108\u7387\u8fbe100%\u3002\u53e6\u5916\uff0c\u4f53\u5916\u7814\u7a76\u663e\u793a\uff0c\u6208\u8bfa\u536b\u00ae\u5bf9\u57fa\u56e01-6\u578b\u7684NS3\/4A\u86cb\u767d\u9176\u4e5f\u8868\u73b0\u51fa\u5f3a\u6548\u6d3b\u6027\u3002<\/span><\/p>\n

\u809d\u764c\u65b0\u836f\u559c\u83b7\u5b64\u513f\u836f\u8d44\u683c<\/span><\/strong><\/p>\n

2018\u5e747\u670810\u65e5\uff0c\u4e2d\u56fd\u53f0\u6e7e\u6d69\u9f0e\u751f\u6280\uff08OBI Pharma\uff09\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u6297\u764c\u65b0\u836fOBI-3424\u83b7\u5f97\u7f8e\u56fdFDA\u9881\u53d1\u7684\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cOBI-3424\u662f\u4e00\u6b3efirst-in-class\u7684\u4ee5\u8fc7\u8868\u8fbe\u919b\u916e\u8fd8\u539f\u91761C3\uff08AKR1C3\uff09\u4e3a\u6807\u9776\u7684DNA\u70f7\u5316\u764c\u75c7\u6cbb\u7597\u836f\u7269\u3002\u6211\u4eec\u4e5f\u671f\u5f85\u50cfOBI-3424\u8fd9\u6837\u7684\u65b0\u578b\u9776\u5411\u6cbb\u7597\u836f\u7269\u53ef\u4ee5\u5c3d\u5feb\u4e3a\u809d\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff01<\/span><\/p>\n

\u767e\u65f6\u7f8e\u65bd\u8d35Nivolumab\u6ce8\u5c04\u6db2\u56fd\u5185\u83b7\u6279\u4e0a\u5e02<\/span><\/strong><\/p>\n

2018\u5e747\u670810\u65e5\uff0c\u4e2d\u56fd\u53f0\u6e7e\u6d69\u9f0e\u751f\u6280\uff08OBI Pharma\uff09\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u6297\u764c\u65b0\u836fOBI-3424\u83b7\u5f97\u7f8e\u56fdFDA\u9881\u53d1\u7684\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cOBI-3424\u662f\u4e00\u6b3efirst-in-class\u7684\u4ee5\u8fc7\u8868\u8fbe\u919b\u916e\u8fd8\u539f\u91761C3\uff08AKR1C3\uff09\u4e3a\u6807\u9776\u7684DNA\u70f7\u5316\u764c\u75c7\u6cbb\u7597\u836f\u7269\u3002\u6211\u4eec\u4e5f\u671f\u5f85\u50cfOBI-3424\u8fd9\u6837\u7684\u65b0\u578b\u9776\u5411\u6cbb\u7597\u836f\u7269\u53ef\u4ee5\u5c3d\u5feb\u4e3a\u809d\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff01<\/span><\/p>\n

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\u536b\u6750 \u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\u80f6\u56ca<\/span><\/strong><\/p>\n

\u4ed1\u4f10\u66ff\u5c3c\u662f\u4e00\u79cd\u591a\u9776\u70b9\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u963b\u6ede\u80bf\u7624\u7ec6\u80de\u5185\u5305\u62ecVEGFR1-3\u3001FGFR1-4\u3001PDGFR\u03b1\u3001KIT\u3001RET\u5728\u5185\u7684\u4e00\u7cfb\u5217\u8c03\u8282\u56e0\u5b50\u3002\u5728\u809d\u764c\u9002\u5e94\u75c7\u4e0a\uff0c\u536b\u67502017\u5e746\u6708\u5728\u65e5\u672c\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\uff0c2017\u5e747\u6708\u5411EMA\u548cFDA\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\uff0c2017\u5e7411\u67083\u65e5\u5411CFDA\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c2017\u5e7412\u65e518\u83b7\u5f97CDE\u7684\u4f18\u5148\u5ba1\u8bc4\u3002FDA\u6388\u4e88\u8fc7\u4ed1\u4f10\u66ff\u5c3c\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u7684\u5b64\u513f\u836f\u8d44\u683c\uff0c\u9884\u8ba1\u5c06\u57287\u6708\u5e95\u524d\u505a\u51fa\u5ba1\u6279\u51b3\u5b9a\u3002\u4ed1\u4f10\u66ff\u5c3c\u5728\u56fd\u5185\u9884\u8ba1\u4f1a\u57282018Q4\u83b7\u5f97CFDA\u6279\u51c6\u3002<\/span><\/p>\n

\u5409\u5229\u5fb7\u79d1\u5b66   Harvoni\u548cVemlidy<\/span><\/strong><\/p>\n

\u5409\u5229\u5fb7\u79d1\u5b66\u4e8e2007\u5e74\u8fdb\u5165\u4e2d\u56fd\u3002\u4eca\u5e745\u670830\u65e5\uff0c\u5409\u5229\u5fb7\u6cdb\u57fa\u56e0\u578b\u6cbb\u7597\u4e19\u809d\u65b0\u836f\u4e19\u901a\u6c99\u5728\u4e2d\u56fd\u83b7\u6279\u3002\u4e19\u901a\u6c99\u00ae\u662f\u4e2d\u56fd\u9996\u4e2a\u901a\u8fc7\u5ba1\u6279\u7684\u6cdb\u57fa\u56e0\u578b HCV \u5355\u4e00\u7247\u5242\u65b9\u6848\uff08STR\uff09\u3002<\/span><\/p>\n

\u540c\u65f6\uff0c\u6765\u8fea\u6d3e\u97e6\u7d22\u78f7\u5e03\u97e6\u7247\uff0c\u5409\u5229\u5fb7\u7684\u7b2c2\u6b3e\u4e19\u809d\u795e\u836fHarvoni\uff08sofosbuvir\u7d22\u975e\u5e03\u97e6+ledipasvir\u96f7\u8fea\u5e15\u97e6\u590d\u65b9\u5236\u5242\uff09\u5df2\u7ecf\u62a5\u4ea7\uff0c2018\u5e74\u5e95\u524d\u83b7\u6279\u662f\u5927\u6982\u7387\u4e8b\u4ef6\u3002\u53f2\u4e0a\u6700\u597d\u7684\u4e59\u809d\u65b0\u836fVemlidy\uff0c\u9884\u8ba12018Q1\u4f1a\u62a5\u4ea7\uff0c\u6709\u671b2018\u5e74\u5e95\u4e4b\u524d\u83b7\u6279\u3002<\/span><\/p>\n

\"\u3010\u56fd\u4eba\u798f\u97f3\u3011\u591a\u6b3e\u836f\u7269\u53ae\u6740\u809d\u75c5\u5927\u56fd\u6700\u540e\u7684\u7ea2\u5229\"
<\/p>\n

\n<\/section>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u533b\u836f\u5730\u7406 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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