{"id":14054,"date":"2018-07-25T01:00:00","date_gmt":"2018-07-30T04:21:03","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/30\/%e8%be%be%e8%8f%b2%e5%9c%b0%e4%bd%8d%e4%b8%8d%e4%bf%9d%ef%bc%9f%e6%9b%bf%e4%bb%a3%e8%8d%af%e7%89%a9%e5%8d%b3%e5%b0%86%e6%a8%aa%e7%a9%ba%e5%87%ba%e4%b8%96%ef%bc%81\/"},"modified":"2018-07-30T12:21:04","modified_gmt":"2018-07-30T04:21:04","slug":"%e8%be%be%e8%8f%b2%e5%9c%b0%e4%bd%8d%e4%b8%8d%e4%bf%9d%ef%bc%9f%e6%9b%bf%e4%bb%a3%e8%8d%af%e7%89%a9%e5%8d%b3%e5%b0%86%e6%a8%aa%e7%a9%ba%e5%87%ba%e4%b8%96%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/14054\/","title":{"rendered":"\u8fbe\u83f2\u5730\u4f4d\u4e0d\u4fdd\uff1f\u66ff\u4ee3\u836f\u7269\u5373\u5c06\u6a2a\u7a7a\u51fa\u4e16\uff01"},"content":{"rendered":"
\n
\n
\n
\n

\u636e\u62a5\u9053\uff0c\u4e00\u79cd\u66ff\u4ee3\u7f57\u6c0fTamiflu\uff08\u8fbe\u83f2\uff0c\u901a\u7528\u540dOseltamivir\uff0c\u5965\u53f8\u4ed6\u97e6\uff09\u7684\u6d41\u611f\u836f\u7269\u5df2\u7ecf\u663e\u793a\u51fa\u7a33\u5b9a\u7597\u6548\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u5168\u65871018\u5b57\uff0c\u7528\u65f62\u5206\u949f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a<\/span>\u8bb8\u5173\u715c\u3001\u674e\u654f\u534e<\/span><\/p>\n

\u636e\u62a5\u9053\uff0c\u4e00\u79cd\u66ff\u4ee3\u7f57\u6c0fTamiflu\uff08\u8fbe\u83f2\uff0c\u901a\u7528\u540dOseltamivir\uff0c\u5965\u53f8\u4ed6\u97e6\uff09\u7684\u6d41\u611f\u836f\u7269\u5df2\u7ecf\u663e\u793a\u51fa\u7a33\u5b9a\u7597\u6548\u3002\u4e00\u9879III\u671f\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u8fd9\u79cd\u65b0\u578b\u6d41\u611f\u836f\u5bf9\u4e25\u91cd\u6d41\u611f\u5e76\u53d1\u75c7\u7684\u9ad8\u98ce\u9669\u4eba\u7fa4\u594f\u6548\uff0c\u8be5\u836f\u53ef\u80fd\u5e2e\u52a9\u7f57\u6c0f\u586b\u8865\u56e0\u4eff\u5236\u836f\u51b2\u51fbTamiflu\u9020\u6210\u7684\u635f\u5931\u3002<\/span><\/p>\n

Xofluza\u662f\u8be5\u836f\u5728\u65e5\u672c\u9500\u552e\u7684\u5546\u54c1\u540d\uff08\u4eca\u5e742\u6708\u83b7\u51c6\uff09\uff0c\u5176\u901a\u7528\u540d\u4e3aBaloxavir marboxil\uff0c\u5728\u4e4b\u524d\u7684\u4e00\u9879\u67091436\u540d\u60a3\u8005\u53c2\u4e0e\u7684III\u671f\u7814\u7a76\uff08CAPSTONE-1\uff09\u4e2d\uff0cXofluza\u6ca1\u6709\u6bd4Tamiflu\u663e\u8457\u7f29\u77ed\u75c7\u72b6\u6301\u7eed\u65f6\u95f4\u3002\u4e0d\u8fc7\uff0c\u4e0eTamiflu\u6bcf\u65e5\u4e24\u6b21\u3001\u4e3a\u671f\u4e94\u5929\u7684\u65b9\u6848\u76f8\u6bd4\uff0cXofluza\u786e\u5b9e\u5177\u6709\u4f18\u52bf\uff0c\u5b83\u901a\u8fc7\u5355\u6b21\u7ed9\u836f\u5c31\u80fd\u83b7\u5f97\u76f8\u540c\u7684\u76ca\u5904\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u79cd\u836f\u7269\u53ef\u4ee5\u572824\u5c0f\u65f6\u5185\u6291\u5236\u6d41\u611f\u75c5\u6bd2\u7684\u6c34\u5e73\uff0c\u800cTamiflu\u5219\u9700\u898172\u5c0f\u65f6\u3002\u53ef\u89c1\uff0cXofluza\u8fc5\u901f\u6539\u5584\u6d41\u611f\u75c7\u72b6\uff0c\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u3002\u53e6\u5916\uff0c\u5b83\u8fd8\u53ef\u4ee5\u9488\u5bf9\u79bd\u6d41\u611f\u75c5\u6bd2H5N1\u548cH7N9\u7684\u6297Tamiflu\u6297\u6027\u75c5\u6bd2\u682a\uff0c\u5feb\u901f\u6740\u706d\u75c5\u6bd2\u4e3a\u53ef\u4ee5\u53ca\u65f6\u963b\u6b62\u75c5\u6bd2\u4f20\u64ad\uff0c\u5728\u67d0\u4e9b\u6b21\u8981\u7ec8\u70b9\u4e2d\uff0c\u4e0eTamiflu\u76f8\u6bd4\uff0c\u5b83\u751a\u81f3\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u7597\u6548\uff0c\u5305\u62ec\u505c\u6b62\u75c5\u6bd2\u91ca\u653e\u548c\u964d\u4f4e\u4f53\u5185\u75c5\u6bd2\u6c34\u5e73\u7684\u65f6\u95f4\u3002<\/span><\/p>\n

CAPSTONE-2\u7814\u7a76\u7eb3\u5165\u4e862000\u591a\u540d\u53c2\u4e0e\u8005\uff0c\u4ed6\u4eec\u4e3a\u7f8e\u56fd\u75be\u63a7\u4e2d\u5fc3\u5b9a\u4e49\u7684\u6709\u6d41\u611f\u5e76\u53d1\u75c7\u98ce\u9669\u3001\u53ef\u5bfc\u81f4\u4f4f\u9662\u751a\u81f3\u6b7b\u4ea1\u7684\u60a3\u8005\uff0c\u5305\u62ec65\u5c81\u6216\u4ee5\u4e0a\u4ee5\u53ca\u60a3\u6709\u54ee\u5598\u3001\u7cd6\u5c3f\u75c5\u548c\u5fc3\u810f\u75c5\u7b49\u75be\u75c5\u4eba\u7fa4\u3002<\/span><\/p>\n

\uff08\u7f57\u6c0f\u65d7\u4e0b\uff09\u57fa\u56e0\u6cf0\u514b\u9996\u5e2d\u533b\u7597\u5b98\u517c\u5168\u7403\u4ea7\u54c1\u5f00\u53d1\u8d1f\u8d23\u4eba\u6851\u5fb7\u62c9\u00b7\u970d\u5b81Sandra Horning\u6307\u51fa\uff0c\u201cBaloxavir marboxil\u662f\u9996\u4e2a\u9488\u5bf9\u6d41\u611f\u5e76\u53d1\u75c7\u654f\u611f\u4eba\u7fa4\uff08\u5305\u62ec\u8001\u5e74\u4eba\u548c\u60a3\u6709\u67d0\u4e9b\u75be\u75c5\u8005\uff09\u7684\u6709\u6548\u836f\u7269\u3002\u201d\u4f46\u57287\u670816\u65e5\u53d1\u5e03\u7684\u6d88\u606f\u4e2d\uff0c\u57fa\u56e0\u6cf0\u514b\u672a\u660e\u786e\u6307\u51faXofluza\u662f\u5426\u6bd4Tamiflu\u66f4\u80fd\u7f13\u89e3\u6d41\u611f\u75c7\u72b6\u6216\u964d\u4f4e\u8fd9\u7c7b\u8106\u5f31\u60a3\u8005\u7684\u6d41\u611f\u5e76\u53d1\u75c7\u53d1\u751f\u7387\u3002<\/span><\/p>\n

\u4e0e\u5176\u4ed6\u76ee\u524d\u53ef\u7528\u7684\u6297\u6d41\u611f\u6cbb\u7597\u76f8\u6bd4\uff0cXofluza\u5728\u75c5\u6bd2\u590d\u5236\u7684\u4e0d\u540c\u9636\u6bb5\u8d77\u4f5c\u7528\u3002\u5b83\u88ab\u8bbe\u8ba1\u7528\u4e8e\u6291\u5236\u5e3d\u72b6\u5185\u5207\u6838\u9178\u9176\u86cb\u767d\uff08cap-dependent endonuclease protein\uff09\uff0c\u4ece\u800c\u963b\u6b62\u6d41\u611f\u75c5\u6bd2\u5728\u4eba\u4f53\u5185\u590d\u5236\u3002\u57fa\u4e8e\u65b0\u9896\u7684\u673a\u5236\u548cIII\u671f\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u7684\u5de8\u5927\u6f5c\u529b\uff0c\u540c\u65f6\uff0c\u56e0\u4e3a\u53bb\u5e74\u7f8e\u56fd\u7ecf\u5386\u4e86\u4e25\u91cd\u7684\u6d41\u611f\uff0c\u5bfc\u81f4\u95e8\u8bca\u548c\u4f4f\u9662\u75c5\u4f8b\u6570\u7834\u5386\u53f2\u7eaa\u5f55\uff0c\u572810\u6708\u81f34\u6708\u76847\u4e2a\u6708\u4e2d\uff0c\u5411\u75be\u63a7\u4e2d\u5fc3\u62a5\u544a\u7684\u786e\u8ba4\u4e0e\u6d41\u611f\u76f8\u5173\u7684\u4f4f\u9662\u6cbb\u7597\u8d85\u8fc73\u4e07\u4f8b\uff0cFDA\u4e8e\u662f\u8ba4\u5b9aXofluza\u4f18\u5148\u5ba1\u67e5\u8d44\u683c\u3002<\/span><\/p>\n

\u76ee\u524dFDA\u6b63\u5728\u6839\u636eCAPSTONE-1\u7814\u7a76\u7ed3\u679c\uff0c\u5bf9\u5176\u5728\u65e0\u5e76\u53d1\u75c7\u6d41\u611f\u60a3\u8005\u4e2d\u7684\u5e94\u7528\u8fdb\u884c\u52a0\u901f\u5ba1\u67e5\uff0c\u5e76\u5c06\u4e8e12\u670824\u65e5\u4f5c\u51fa\u51b3\u5b9a\u3002\u5982\u679c\u83b7\u51c6\uff0c\u5b83\u5c06\u6210\u4e3a\u8fd120\u5e74\u6765\u7b2c\u4e00\u4e2a\u5177\u6709\u5d2d\u65b0\u4f5c\u7528\u673a\u5236\u7684\u6d41\u611f\u836f\u7269\u3002\u970d\u5b81\u8868\u793a\uff0c\u8be5\u516c\u53f8\u5c06\u5411FDA\u63d0\u4ea4\u4e0a\u8ff0\u65b0\u7684III\u671f\u7ed3\u679c\uff0c\u4ee5\u8ba8\u8bba\u540e\u7eed\u8ba1\u5212\u3002<\/span><\/p>\n

\u57fa\u56e0\u6cf0\u514b\u901a\u8fc7\u4e0e\u76d0\u91ce\u4e49\u7b7e\u8ba2\u76842016\u5e74\u8bb8\u53ef\u534f\u8bae\u83b7\u5f97\u4e86Xofluza\u7684\u5546\u4e1a\u6743\u5229\uff0c\u540e\u8005\u5728\u5728\u65e5\u672c\u548c\u53f0\u6e7e\u62e5\u6709\u8be5\u836f\u7684\u6743\u5229\uff0c\u5e76\u5728\u7f8e\u56fd\u62e5\u6709\u5171\u540c\u9500\u552e\u6743\u3002\u8be5\u836f\u5728\u7f8e\u56fd\u7684\u5546\u54c1\u540d\u672a\u5b9a\u3002<\/span><\/p>\n

2017\u5e74\u662fTamiflu\u906d\u53d7\u201c\u5c71\u5be8\u201d\u4ea7\u54c1\u4fb5\u8680\u7684\u7b2c\u4e00\u5e74\uff0c\u9500\u552e\u989d\u4e0b\u964d33\uff05\uff0c\u8dcc\u81f35.35\u4ebf\u745e\u58eb\u6cd5\u90ce\uff085.37\u4ebf\u7f8e\u5143\uff09\u3002\u800c\u76ee\u524d\u6765\u770bXofluza\u6709\u53ef\u80fd\u5b8c\u5168\u66ff\u4ee3Tamiflu\u7684\u54c1\u3002\u7f57\u6c0f\u9700\u8981\u6709\u540e\u7eed\u4ea7\u54c1\u586b\u8865Tamiflu\u4eff\u5236\u836f\u6269\u5927\u9500\u552e\u5e26\u6765\u7684\u7ecf\u6d4e\u635f\u5931\u3002<\/span><\/p>\n

\u8fd1\u671f<\/span>\u7cbe\u5f69<\/span>\u56de\u987e<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n<\/section>\n
<\/section>\n
\n

\u6d6a\u6f6e\u5d1b\u8d77\uff0c\u56fd\u5185\u521b\u65b0\u836f\u8fce\u6765\u53d1\u5c55\u6625\u5929\uff01<\/a>
<\/p>\n

2017\u5e74\u6b63\u5927\u5929\u6674\u56fd\u5185\u9500\u552e\u6982\u51b5<\/a><\/p>\n<\/section>\n

\u96f6\u7a81\u7834\uff01\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u6297\u827e\u6ecb\u75c5\u836f\u7269\u83b7\u6279\u4e0a\u5e02\uff01\uff01<\/a><\/span><\/p>\n

\"\u8fbe\u83f2\u5730\u4f4d\u4e0d\u4fdd\uff1f\u66ff\u4ee3\u836f\u7269\u5373\u5c06\u6a2a\u7a7a\u51fa\u4e16\uff01\"
<\/p>\n

\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u533b\u836f\u5730\u7406 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u636e\u62a5\u9053\uff0c\u4e00\u79cd\u66ff\u4ee3\u7f57\u6c0fTamiflu\uff08\u8fbe\u83f2\uff0c\u901a\u7528\u540dOseltamivir\uff0c\u5965\u53f8\u4ed6\u97e6\uff09\u7684\u6d41\u611f\u836f\u7269\u5df2\u7ecf\u663e\u793a\u51fa\u7a33\u5b9a\u7597\u6548 […]<\/p>\n","protected":false},"author":1,"featured_media":14055,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/14054"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=14054"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/14054\/revisions"}],"predecessor-version":[{"id":14057,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/14054\/revisions\/14057"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/14055"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=14054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=14054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=14054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}