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2005\u5e74\uff0cWu \u548c Benet\u4fee\u8ba2\u4e86BCS\u7684\u6982\u5ff5\uff0c\u8bd5\u56fe\u89e3\u51b3\u6e17\u900f\u6027\u5b9a\u4e49\u4e0a\u7684\u6b67\u4e49\u3002\u4ed6\u4eec\u63d0\u51fa\u9ad8\u6e17\u900f\u836f\u7269\u901a\u5e38\u4e3b\u8981\u901a\u8fc7\u4ee3\u8c22\u6765\u6d88\u9664\uff0c\u5e76\u4ee5\u836f\u7269\u7684\u6eb6\u89e3\u6027\u548c\u4ee3\u8c22\u7a0b\u5ea6\u4e3a\u57fa\u7840\uff0c\u63d0\u51fa\u4e86BDDCS\u5206\u7c7b\u7cfb\u7edf\u3002\u5173\u4e8e\u6e17\u900f\u6027\u5b9a\u4e49\u7684\u6b67\u4e49\u5728\u5176\u4ed6\u62a5\u544a\u4e2d\u4e5f\u6709\u8fdb\u4e00\u6b65\u9610\u8ff0\uff0c\u4f46\u4ecd\u672a\u89e3\u91ca\u6e05\u695a\u3002\u5c3d\u7ba1\u5982\u6b64\uff0cBCS\u548cBDDCS\u7684\u652f\u6301\u8005\u8ba4\u4e3a\uff0c\u836f\u7269\u7684\u4ee3\u8c22\u7a0b\u5ea6\u5c06\u589e\u52a0BCS\u5e94\u7528\u7684\u4ef7\u503c\uff0c\u56e0\u4e3a\u5b83\u80fd\u66f4\u597d\u5730\u53cd\u6620\u836f\u7269\u5438\u6536\u60c5\u51b5\u3002\u836f\u7269\u7684\u4ee3\u8c22\u7a0b\u5ea6\uff0c\u53ef\u4ee5\u7528\u6c27\u5316\u6216\u5171\u8f6d\u9176\u5f62\u6210\u7684\u4ee3\u8c22\u7269\u7684\u91cf\u6765\u8868\u793a\u3002EMA\u6307\u5357\u7b2c\u4e00\u4e2a\u6307\u51fa\u5c06\u4ee3\u8c22\u7a0b\u5ea6\u4f5c\u4e3a\u836f\u7269\u5438\u6536\u7684\u6307\u6807\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6839\u636eBDDCS\u5206\u7c7b\uff0c\u4e00\u4e9b\u4e13\u5bb6\u6307\u51fa\u7531\u4e8e\u4e0d\u540c\u7fa4\u4f53\u7684\u57fa\u56e0\u5206\u5e03\u591a\u6837\u6027,\u836f\u7269\u4ee3\u8c22\u76f8\u5173\u7684\u57fa\u56e0\u591a\u6001\u6027\u4f1a\u5bfc\u81f4\u4e0d\u540c\u5206\u7c7b\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9274\u4e8e\u91c7\u7528BCS\/BDDCS\u5206\u7c7b\u5728BE\u8c41\u514d\u8fc7\u7a0b\u4e2d\u7684\u5e94\u7528\u4ecd\u7f3a\u4e4f\u7edf\u4e00\u6027\uff0c\u672c\u6587\u5f00\u5c55\u4e86\u73b0\u51b5\u8c03\u67e5\uff0c\u4ee5\u8bc4\u4f30BCS\u548cBDDCS\u6bcf\u4e2a\u7b49\u7ea7\u836f\u7269\u7684BE\u4e0d\u7b49\u6548\u548cBIE\uff08bioinequivalent\uff09\u98ce\u9669\u3002\u8be5\u9879\u8c03\u67e5\u540c\u65f6\u8bc4\u4f30\u4f53\u5916\u6eb6\u51fa\u7528\u4e8e\u9884\u6d4b\u4e24\u4e2a\u5206\u7c7b\u7cfb\u7edf\u7684BE\u7ed3\u679c\u7684\u60c5\u51b5\u3002\u76ee\u7684\u662f\u91c7\u7528\u56de\u987e\u6027\u6570\u636e\u6765\u786e\u5b9a\u751f\u7269\u8c41\u514d\u6269\u5c55\u5230\u2161\u548c\u2163\u7c7b\u836f\u7269\u53ef\u884c\u6027\u3002<\/span><\/p>\n

\n
\n
\n
\"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/section>\n<\/section>\n
\n
\u8bd5\u9a8c<\/span><\/strong><\/section>\n<\/section>\n
\n
\"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u8be5\u8c03\u67e5\u4ece\u5df4\u897f\u536b\u751f\u76d1\u7763\u5c40\uff08ANVISA\uff09\u5185\u90e8\u7684BE\u7814\u7a76\u6570\u636e\u5e93\u4e2d\u968f\u673a\u53d6\u6837\uff0c\u8be5\u7cfb\u7edf\u7535\u5b50\u8bb0\u5f55\u4e86\u4ece2008\u5e74\u8d77\u5df4\u897f\u5f00\u5c55\u7684\u6240\u6709\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff0c\u5305\u62ecBE\u7b49\u6548\u3001BE\u4e0d\u7b49\u6548\u548cBIE\uff08bioinequivalent\uff09\u7ed3\u679c\uff08BIE\u6307statistic power\uff08\u7edf\u8ba1\u529f\u6548<\/span>\uff09\uff1e80%\u7684\u8bd5\u9a8c\u4e2d\uff0c\u70b9\u4f30\u8ba1\u503c\u8d85\u8fc70.8-1.25\u7684\u60c5\u51b5\uff09\u3002\u8003\u8651\u5230BCS\u6bcf\u4e2a\u7c7b\u578b\u7684BE\u4e0d\u7b49\u6548\u7ed3\u679c\u5df2\u6709\u62a5\u9053\uff0c\u6837\u672c\u5927\u5c0f\u6309OpenEpi2.3.1\u7248\u7edf\u8ba1\uff0c\u5fc5\u987b\u8fbe\u5230\u9a8c\u524d statistic power <\/span>\u768480%\uff0c\u663e\u8457\u6c34\u5e73\u8fbe0.05%\u3002\u7531\u4e8eBCS\u2160\u7c7b\u548c\u2162\u7c7b\u836f\u7269\u7684BE\u4e0d\u7b49\u6548\u7ed3\u679c\u5b58\u5728\u8f83\u5c0f\u5dee\u5f02\uff0c\u6837\u672c\u5927\u5c0f\u8981\u6c42\u7edd\u5bf9\u62d2\u7edd\u65e0\u6548\u7684\u539f\u5047\u8bbe\uff08H0:relative risk = 1\uff1b\u603b\u6837\u672c\u4e3a13300\u4e2aBE\u8bd5\u9a8c\uff09\u8fdc\u8fdc\u9ad8\u4e8e\u751f\u7269\u7b49\u6548\u6027\u548c\u836f\u5b66\u7b49\u6548\u6027\u7cfb\u7edf\u7684\u603b\u6570\u3002\u6240\u4ee5\uff0c\u6837\u672c\u5927\u5c0f\u4ec5\u8003\u8651BCS\u2160\u3001\u2162\u3001\u548c\u2163\u7c7b\u4e0e\u2161\u7c7b\u5bf9\u6bd4\u3002\u8be5\u7b97\u6cd5\u8868\u660eBCS\u6bcf\u4e2a\u7c7b\u578b\u81f3\u5c11\u9700\u8981\u8fdb\u884c96\u9879BE\u8bd5\u9a8c\u3002\u8003\u8651\u5230\u6ce8\u518c\u4eff\u5236\u836f\u4e2d\u7684BCS\u4e0d\u540c\u7c7b\u522b\u5206\u5e03\u60c5\u51b5\uff0c\u6211\u4eec\u968f\u673a\u4ece\u751f\u7269\u7b49\u6548\u6027\u548c\u836f\u5b66\u7b49\u6548\u6027\u7cfb\u7edf\u4e2d\u62bd\u53d6500\u4e2a\u6837\u672c\u836f\u7269\u7684BE\u8bd5\u9a8c\u6570\u636e\uff0c\u8db3\u4ee5\u7edf\u8ba1\u8bc4\u4f30\u836f\u7269\u7279\u6027\uff08\u6eb6\u89e3\u6027\u3001\u80a0\u9053\u901a\u900f\u6027\u548c\u836f\u7269\u4ee3\u8c22\u7a0b\u5ea6\uff09\u548c\u5242\u578b\uff08\u4f53\u5916\u6eb6\u51fa\u5ea6\uff09\u662f\u5982\u4f55\u5f71\u54cdBE\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u6240\u6709\u7684\u8bd5\u9a8c\u53d6\u6837\u5747\u7531\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\uff0c\u7531\u901a\u8fc7GLP\u548cGCP\u8ba4\u8bc1\u7684\u533b\u836f\u7814\u53d1\u5916\u5305\u516c\u53f8\uff08CRO\uff09\u6267\u884c\uff0c\u5e76\u9075\u7167Helsinki\u5ba3\u8a00\u548c\u5df4\u897f\u6cd5\u5f8b\u3002\u5e76\u6536\u96c6\u4e86\u7ecf\u836f\u5178\u6216\u9a8c\u8bc1\u8bd5\u9a8c\u540e\u5f97\u51fa\u7684\u6709\u53c2\u8003\u610f\u4e49\u7684\u4f53\u5916\u6eb6\u51fa\u5ea6\u6570\u636e\u3002<\/span><\/p>\n


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\u836f\u7269\u5206\u7c7b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u836f\u7269\u6309\u7167BDDCS\u8fdb\u884c\u5206\u7c7b\uff0c\u8be6\u89c1\u524d\u9762\u5217\u8868\u3002\u8be5\u5217\u8868\u5c55\u793a\u4e86\u5728PH1.0-7.5\u8303\u56f4\u5185\u836f\u7269\u6eb6\u89e3\u5ea6\u4ee5\u53ca\u8ba1\u7b97\u6cb9\u6c34\u5e73\u8861\u7cfb\u6570clogP\u503c\uff0c\u5e76\u91c7\u7528clogP\u503c\u5bf9\u6837\u672c\u836f\u7269\u8fdb\u884cBCS\u5206\u7c7b\u3002\u672c\u6587\u9009\u62e9\u7f8e\u6258\u6d1b\u5c14\u4f5c\u4e3a\u80a0\u9053\u6e17\u900f\u6027\u7684\u6807\u51c6\u836f\u7269\uff0c\u662f\u56e0\u4e3a\u5b83\u7684\u7edd\u5bf9\u751f\u7269\u5229\u7528\u5ea6\u7ea6\u4e3a90%\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0cclogP\u503c\u9ad8\u4e8e\u6216\u7b49\u4e8e\u7f8e\u6258\u6d1b\u5c14\u7684\u836f\u7269\u5747\u88ab\u8ba4\u4e3a\u662f\u9ad8\u6e17\u900f\u7684\u836f\u7269\u3002<\/span><\/p>\n


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\u6570\u636e\u5206\u6790<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u91c7\u7528\u5361\u65b9\u68c0\u9a8c\uff08\u5982\u9002\u7528\uff0c\u6216\u8d39\u820d\u5c14\u7cbe\u786e\u68c0\u9a8c\uff09\u6d4b\u7b97\u751f\u7269\u4e0d\u7b49\u6548\u7ed3\u679c\u5728BCS\u6216BDDCS\u6240\u6709\u7c7b\u578b\u7684\u5360\u6bd4\u3002\u91c7\u7528\u591a\u4e2a2*2\u5217\u8054\u8868\u8fdb\u884c\u6bd4\u8f83BCS\u6216BDDCS\u6bcf\u4e2a\u7c7b\u578b\u7684\u6240\u6709\u7ec4\u5408\uff0c\u5e76\u8ba1\u7b97\u751f\u7269\u4e0d\u7b49\u6548\u6216BIE\u7684\u76f8\u5173\u98ce\u9669\uff0c\u4ee5\u53ca\u5b83\u4eec\u768495%\u7f6e\u4fe1\u533a\u95f4\u3002\u6570\u636e\u5206\u6790\u91c7\u7528SPSS 17\u7248\u8f6f\u4ef6\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\uff0c P<0.05\u88ab\u8ba4\u4e3a\u662f\u6709\u610f\u4e49\u7684\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u901a\u8fc7\u7075\u654f\u5ea6\uff08sensitivity\uff09\u3001\u7279\u5f02\u6027\uff08specificity\uff09\u3001\u9633\u6027\u4f3c\u7136\u6bd4\uff08LR+\uff1alikelihood ratio positive\uff09\u3001\u9634\u6027\u4f3c\u7136\u6bd4\uff08LR-\uff1alikelihood ratio negative\uff09\u548c\u9a8c\u540e<\/span>\u6982\u7387\uff08post test probability\uff09\u7b49\u53c2\u6570\u5bf9\u4f53\u5916\u6eb6\u51fa\u5ea6\u8bd5\u9a8c\u4e0e\u751f\u7269\u7b49\u6548\u6027\u7ed3\u679c\u95f4\u7684\u53ef\u9884\u6d4b\u6027\u8fdb\u884c\u8bc4\u4f30\u3002\u7075\u654f\u5ea6\u662f\u6307\u5047\u5b9a\u4e00\u4e2a\u4eff\u5236\u836f\u662f\u751f\u7269\u7b49\u6548\u7684\uff0c\u68c0\u6d4b\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u76f8\u4f3c\u7684\u6761\u4ef6\u6982\u7387\u3002\u76f8\u53cd\uff0c\u7279\u5f02\u6027\u6307\u5047\u5b9a\u4e00\u4e2a\u4eff\u5236\u836f\u662f\u751f\u7269\u4e0d\u7b49\u6548\u7684\uff0c\u68c0\u6d4b\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0d\u76f8\u4f3c\u7684\u6761\u4ef6\u6982\u7387\u3002\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u7684\u4e92\u8865\u6982\u7387\u5206\u522b\u662f\u5047\u9634\u6027\u548c\u5047\u9633\u6027\u6982\u7387\u3002LR+\u6307\u7075\u654f\u5ea6\u548c\u5047\u9633\u6027\u6982\u7387\u7684\u6bd4\u503c\u3002\u6362\u800c\u8a00\u4e4b\uff0c\u6eb6\u51fa\u8bd5\u9a8c\u7684LR+\u662f\u6307\u751f\u7269\u7b49\u6548\u836f\u7269\u53ef\u80fd\u51fa\u73b0\u76f8\u4f3c\u7684\u4f53\u5916\u6eb6\u51fa\u60c5\u51b5\u6bd4\u751f\u7269\u975e\u7b49\u6548\u836f\u7269\u591a\u7684\u500d\u6570\u3002\u76f8\u53cd\uff0cLR-\u662f\u7279\u5f02\u6027\u548c\u5047\u9634\u6027\u6982\u7387\u7684\u6bd4\u503c\uff0c\u8868\u793a\u751f\u7269\u7b49\u6548\u836f\u7269\u53ef\u80fd\u51fa\u73b0\u4e0d\u76f8\u4f3c\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u6bd4\u751f\u7269\u975e\u7b49\u6548\u836f\u7269\u5c11\u7684\u500d\u6570\u3002LR+\u5927\u4e8e1\u8868\u660e\u76f8\u4f3c\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0e\u751f\u7269\u7b49\u6548\u7ed3\u679c\u76f8\u5173\uff0c\u800cLR-\u5c0f\u4e8e1\u8868\u660e\u4f53\u5185\u4e0d\u76f8\u4f3c\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0e\u751f\u7269\u975e\u7b49\u6548\u7ed3\u679c\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u5f53LR\u7684\u7f6e\u4fe1\u533a\u95f4\u4e3a95%\u548c100%\u65f6\u662f\u6ca1\u6709\u8bca\u65ad\u4ef7\u503c\uff08diagnosis value\uff09\u7684\u3002\u5c3d\u7ba1\u8fd9\u56db\u4e2a\u6307\u6807\u6982\u8ff0\u4e86\u8bca\u65ad\u51c6\u786e\u6027\uff0c\u4f46\u5b83\u4eec\u4ec5\u4ec5\u5f3a\u8c03BE\u7b49\u6548\uff08\u6216BE\u4e0d\u7b49\u6548\uff09\u7ed3\u679c\u9884\u6d4b\u4f53\u5916\u6eb6\u51fa\u7ed3\u679c\u7684\u51c6\u786e\u6027\uff0c\u56e0\u4e3a\u5b83\u4eec\u8868\u660e\u6761\u4ef6\u6982\u7387\uff0c\u5373\u9a8c\u524d\u6761\u4ef6\u662f\u4f53\u5185\u8bd5\u9a8c\u7684\u7ed3\u679c\uff08\u5982\uff1a\u7ed9\u51faBE\u7ed3\u679c\uff0c\u627e\u5230\u76f8\u4f3c\u7684\u4f53\u5916\u6eb6\u51fa\u6982\u7387\u662f\u591a\u5927\uff09\u3002\u7136\u800c\uff0c\u5728\u76d1\u7ba1\u9886\u57df\u5185\uff0c\u4eba\u4eec\u5bf9\u4f53\u5916\u8bd5\u9a8c\u5982\u4f55\u66f4\u597d\u5730\u9884\u6d4bBE\u7ed3\u679c\u66f4\u611f\u5174\u8da3\u3002\u8fd9\u662f\u53ef\u4ee5\u901a\u8fc7\u9a8c<\/span>\u540e<\/span>\u6982\u7387\u6765\u8bc4\u4f30\u7684\uff0c\u800c\u9a8c<\/span>\u540e<\/span>\u6982\u7387\u53ef\u4ee5\u901a\u8fc7BE\u7b49\u6548\u548cBE\u4e0d\u7b49\u6548\u7ed3\u679c\u7684\u9a8c\u524d\u6982\u7387\u548c\u76f8\u4f3c\u7136\u51fd\u6570\uff08LR+\u3001LR-\uff09\u7684\u7ec4\u5408\u8ba1\u7b97\u51fa\u6765\u3002\u6839\u636e\u8d1d\u53f6\u65af\u5b9a\u7406\uff0c\u8fd9\u79cd\u7ec4\u5408\u6982\u8ff0\u4e86\u76f8\u4f3c\u6216\u4e0d\u76f8\u4f3c\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u662f\u5982\u4f55\u6539\u53d8\u83b7\u5f97BE\u7b49\u6548\u6216BE\u4e0d\u7b49\u6548\u7ed3\u679c\u6982\u7387\u7684\u9a8c\u524d\u77e5\u8bc6\u3002\u4e3a\u4e86\u5e94\u7528\u9a8c<\/span>\u540e<\/span>\u6982\u7387\uff0c\u9700\u8981\u7528\u989d\u5916\u7684\u8ba1\u7b97\u65b9\u6cd5\uff08\u8be6\u89c1\u540e\u9762\u7684\u53c2\u8003\uff09\u5c06\u53ef\u80fd\u6027\u8f6c\u6362\u4e3a\u6982\u7387\u3002\u7528\u4ee3\u6570\u7684\u65b9\u6cd5\uff0c\u8fd9\u4e9b\u8bca\u65ad\u53c2\u6570\uff08diagnosis parameters<\/span>\uff09\u7684\u5b9a\u4e49\u53c2\u89c1\u4e0b\u65b9\uff08Table 1\uff09\uff1a<\/span><\/span><\/p>\n


<\/p>\n

    \n
  • \n

    \u7075\u654f\u5ea6=a\/(a+c)  [Sensitivity =a\/(a+c)]<\/em><\/span><\/span><\/p>\n<\/li>\n

  • \n

    \u7279\u5f02\u6027=d\/(b+d)  [Specificity =d\/(b+d)]<\/em><\/span><\/span><\/p>\n<\/li>\n

  • \n

    LR+=\u7075\u654f\u5ea6\/(1-\u7279\u5f02\u6027)  [LR+ = sensitivity\/(1\u2212 specificity)]<\/span><\/em><\/span><\/p>\n<\/li>\n

  • \n

    LR-=\uff081-\u7075\u654f\u5ea6\uff09\/\u7279\u5f02\u6027  [LR\u2212 =(1\u2212 sensitivity)\/specificity]<\/span><\/em><\/span><\/p>\n<\/li>\n

  • \n

    \u9a8c\u540e<\/span>\u6982\u7387BE=\u9a8c<\/span>\u540e<\/span>\u6bd4BE\/\uff081+\u9a8c<\/span>\u540e<\/span>\u6bd4BE\uff09<\/span>[Post test probability BE =posttest oddsBE\/(1 + posttest oddsBE)]<\/span><\/em><\/span><\/p>\n<\/li>\n

  • \n

    \u9a8c\u540e\u6bd4BE=\u9a8c\u524d\u6bd4BE * LR+     [Posttest odds BE =pretest odds BE \u00d7 LR+]<\/span><\/em><\/span><\/p>\n<\/li>\n

  • \n

    \u9a8c\u524d\u6bd4BE=\u53d1\u751f\u7387BE\/\uff081-\u53d1\u751f\u7387BE\uff09  [Pretest oddsBE= prevalence BE\/(1 \u2212prevalenceBE)]<\/span><\/em><\/span><\/p>\n<\/li>\n

  • \n

    \u53d1\u751f\u7387BE=\u9a8c\u524d\u6982\u7387BE=\uff08a+c\uff09\/(a+b+c+d)  [Prevalence BE =pre test probabilityBE = (a +c)\/(a+b +c +d)]<\/span><\/em><\/span><\/p>\n<\/li>\n

  • \n

    \u9a8c\u540e\u6bd4BE\u4e0d\u7b49\u6548=\u9a8c\u524d\u6bd4BE\u4e0d\u7b49\u6548*\uff081\/LR-\uff09   [Posttest oddsnon-BE= pretest oddsnon-BE \u00d7(1\/LR\u2212)]<\/span><\/em><\/span><\/p>\n<\/li>\n<\/ul>\n


    <\/p>\n

    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n

    \u7075\u654f\u5ea6\u3001\u7279\u5f02\u6027\u3001LR+\u3001LR-\u768495%\u7f6e\u4fe1\u533a\u95f4\uff08CI\uff09\u91c7\u7528\u4e0a\u8ff0\u7684\u65b9\u6cd5\u8ba1\u7b97\u3002<\/span><\/p>\n

    <\/span><\/p>\n

    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n

    \u7ed3\u679c<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u6240\u6709BE\u8bd5\u9a8c\u6837\u672c\u836f\u7269\u5747\u4e3a\u4e0d\u5728\u53e3\u8154\u90e8\u4f4d\u5438\u6536\u7684\u901f\u91ca\u5236\u5242\u3002\u6b64\u5916\uff0c\u672c\u6b21\u8c03\u67e5\u4ec5\u5305\u542b\u9a8c\u540e<\/span> <\/span>statistic power <\/span>\u9ad8\u4e8e80%\u7684BE\u4e0d\u7b49\u6548\u8bd5\u9a8c\uff0c\u56e0\u6b64\uff0c\u70b9\u4f30\u503c\u5728BE\u8bd5\u9a8c\u754c\u9650\u4ee5\u5916\u7684BE\u4e0d\u7b49\u6548\u8bd5\u9a8c\u5047\u8bbe\u4e3aBIE\uff1b\u6362\u800c\u8a00\u4e4b\uff0cBE\u4e0d\u7b49\u6548\u7ed3\u679c\u662f\u56e0\u4e3a\u8bd5\u9a8c\u836f\u7269\u548c\u53c2\u6bd4\u5236\u5242\u7684\u5dee\u5f02\u9020\u6210\u7684\u3002<\/span><\/span><\/p>\n

     <\/span><\/p>\n

    114\u4e2a\u836f\u7269\u4e2d107\u79cd\u836f\u7269\u6309\u7167BCS\u548cBDDCS\u5206\u7c7b\uff0c\u4ee3\u8868\u768495%\u6837\u672c\u8bd5\u9a8c\u836f\u7269\uff08475\uff09\u3002Figure 1\u4e3aBCS\u548cBDDCS\u6bcf\u4e2a\u7c7b\u522b\u7684\u53d6\u6837\u836f\u7269\u5206\u5e03\u3002<\/span><\/p>\n

     <\/p>\n

    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n

    Figure 1. Distribution of drugs sampledbetween BCS and BDDCS classes.<\/span><\/p>\n

     <\/p>\n

    \u5f3a\u4ee3\u8c22\u578b\u836f\u7269\u662f\u6307\u4ee3\u8c22\u7387\u9ad8\u4e8e70%\u7684\u836f\u7269\uff0c\u800c\u5f31\u4ee3\u8c22\u578b\u836f\u7269\u662f\u6307\u4ee3\u8c22\u7387\u4f4e\u4e8e\u4e34\u754c\u503c\u7684\u836f\u7269\u3002\u4eb2\u6cb9\u6027\u836f\u7269\u4e2d\uff0c66\u4e2a\u5f3a\u4ee3\u8c22\u578b\u836f\u7269\u4ee3\u8c22\u7387\u9ad8\u4e8e\u7f8e\u6258\u6d1b\u5c14\uff0c23\u4e2a\u5f31\u4ee3\u8c22\u578b\u836f\u7269\u4ee3\u8c22\u7387\u4f4e\u4e8e\u7f8e\u6258\u6d1b\u5c14\u3002\u76f8\u53cd\uff0c\u67099\u79cd\u836f\u7269\u8868\u73b0\u51fa\u826f\u597d\u7684\u4eb2\u6cb9\u6027\uff0c\u4ee3\u8c22\u7387\u9ad8\u4e8e70%\uff0c\u4f46\u5176clog P\u4f4e\u4e8e\u7f8e\u6258\u6d1b\u5c14\uff0c\u56e0\u6b64\u4e5f\u88ab\u5206\u4e3a\u5f31\u4ee3\u8c22\u578b\u836f\u7269\u3002\u591a\u4f4d\u4e13\u5bb6\u6307\u51fa\uff0c\u4ea7\u751f\u8fd9\u79cd\u4e0d\u4e00\u4e00\u5bf9\u5e94\u539f\u56e0\uff0c\u4e3b\u8981\u662f\u809d\u7ec6\u80de\u5185\u4ee3\u8c22\u9176\u7684\u5dee\u5f02\u6216\u57fa\u4e8e\u8f6c\u8fd0\u6216\u8f7d\u4f53\u8f6c\u8fd0\u7684\u836f\u7269\u5438\u6536\u673a\u5236\u4f18\u52bf\u9020\u6210\u7684<\/span><\/p>\n

     <\/span><\/p>\n

    \u5728\u4e24\u79cd\u5206\u7c7b\u7cfb\u7edf\u7684\u6240\u6709\u7c7b\u7c7b\u522b\uff0cCmax\u548cAUC0\u2013t\u5747\u51fa\u73b0BE\u4e0d\u7b49\u6548\u7ed3\u679c\u3002BE\u4e0d\u7b49\u6548\u53d1\u751f\u7387\u4e3a10%\uff08\u2162\u7c7b\uff09-40%\uff08\u2161\u7c7b\uff09\u3002BCS\u548cBDDCS\u6240\u6709\u5206\u7c7b\u4e2d\u90fd\u51fa\u73b0BIE\u7ed3\u679c\u3002\uff08\u8be6\u89c1Table2\uff09<\/span><\/p>\n


    <\/p>\n

    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n


    <\/p>\n

    Table 3\u4e3aBCS\u6216BDDCS\u6bcf\u4e2a\u7c7b\u522b\u51fa\u73b0BE\u4e0d\u7b49\u6548\u6216BIE\u98ce\u9669\u7684\u6bd4\u8f83\uff08\u4e24\u4e24\u6bd4\u8f83\uff09\u3002\u603b\u7ed3\uff0c\u4e0d\u7ba1\u6839\u636eBCS\u8fd8\u662fBDDCS\u5206\u7c7b\uff0c\u2161\u7c7b\u836f\u7269\u51fa\u73b0BE\u4e0d\u7b49\u6548\u98ce\u9669\u662f\u9ad8\u6eb6\u89e3\u836f\u7269\u76842.5-4\u500d\u3002\u5728\u6240\u6709\u6bd4\u8f83\u4e2d\uff0cstatistic power <\/span>\u5747\u9ad8\u4e8e99%\uff08\u4ee5OpenEpi2.3.1.\u7248\u8ba1\u7b97\uff09\u3002\u4f46\u662f\uff0c\u6b64\u6b21\u8c03\u67e5\u65e0\u6cd5\u4fdd\u8bc1\u2160\u7c7b\u548c\u2162\u7c7b\u836f\u7269\u6bd4\u8f83\u548c\u5305\u542b\u2163\u7c7b\u836f\u7269\u7684\u4efb\u4f55\u6bd4\u8f83\u5747\u5177\u6709\u8db3\u591f\u7684 statistic power<\/span>\uff08\u4e3b\u8981\u662f\u56e0\u4e3a\u5728\u672c\u6b21\u53d6\u6837\u4e2dBCS\u2163\u7c7b\u836f\u7269\u8f83\u5c11\uff0c\u4ec5\u4e3a2.8%\uff09\u3002\u7531\u4e8e\u6d89\u53caBCS\u6216BDDCS\u2163\u7c7b\u836f\u7269\u7684\u6bd4\u8f83\u4e0d\u5177\u5907 statistic power<\/span>\uff0c\u6d89\u53ca\u6b64\u7c7b\u836f\u7269\u7684\u8bd5\u9a8c\u5c06\u6392\u9664\u5728\u4ee5\u4e0b\u5206\u6790\u4e4b\u5916\u3002<\/span><\/p>\n


    <\/p>\n

    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n


    <\/p>\n

    \u5bf9\u4e8e\u6240\u6709BCS\u548cBDDCS\u6bcf\u4e2a\u7c7b\u522b\u836f\u7269\uff0c\u5728\u5355\u4e00\u8bd5\u9a8c\u6761\u4ef6\u4e0b\uff0c\u91c7\u7528\u836f\u5178\u6216\u5df2\u9a8c\u8bc1\u7684\u65b9\u6cd5\u8fdb\u884c\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u7684\u6d4b\u5b9a\uff0c\u5e76\u8bc4\u4f30\u7684BE\u7ed3\u679c\u5bf9\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u7684\u9884\u6d4b\u6027\u3002\u62bd\u53d6\u7684475\u4e2a\u6837\u672c\u836f\u7269\u4e2d29\u4e2a\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u7684\u5bf9\u6bd4\u6570\u636e\uff1b\u56e0\u6b64\uff0c\u7075\u654f\u5ea6\u3001\u7279\u5f02\u6027\u3001LR+\u3001LR-\u548c\u9a8c\u540e<\/span>\u6982\u7387\u7b49\u8bca\u65ad\u53c2\u6570\u5206\u522b\u4ee5432\u4e2aBCS\u548c417\u4e2aBDDCS\u7684\u2160-\u2162\u7c7b\u836f\u7269\u4f5c\u7edf\u8ba1\uff08\u8be6\u89c1table 4\u548ctable5\uff09<\/span><\/span><\/p>\n


    <\/span><\/span><\/p>\n

    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n


    <\/p>\n

    \u5728BCS\u6216BDDCS\u2160\u7c7b\u4eff\u5236\u836f\u4e2d\uff0c\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u76f8\u4f3c\u7684\u836f\u7269BE\u7b49\u6548\u53ef\u80fd\u6027\u5927\u6982\u662fBE\u4e0d\u7b49\u65481.7\u500d\uff0c\u800c\u4e14\u5f53\u8bd5\u9a8c\u836f\u54c1\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0e\u53c2\u6bd4\u836f\u7269\u76f8\u4f3c\u65f6\uff0c BE\u7b49\u6548\u6210\u529f\u7387\u4f1a\u589e\u52a0\u523090\u3002\u540c\u65f6\uff0c\u9ad8\u6eb6\u89e3\u836f\u7269\u8fdb\u884c\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u540e\uff0cBE\u4e0d\u7b49\u6548\u7684\u7ed3\u679c\u53ef\u9884\u6d4b\u6027\u4e5f\u4f1a\u660e\u663e\u63d0\u9ad8\u3002\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0d\u76f8\u4f3c\uff0c BCS\u2160\u6216\u2162\u7c7b\u836f\u7269non-BE\u7ed3\u679c\u7684\u9a8c\u540e<\/span>\u6982\u7387\u6bd4\u76f8\u5bf9\u9a8c\u524d\u6982\u7387\u9ad84.5\u62162.5\u500d\u3002<\/span><\/span><\/p>\n


    <\/p>\n

    \u76f8\u53cd\uff0c\u2161\u7c7b\u836f\u7269\u7684\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u5bf9\u5224\u65adBE\u7b49\u6548\u6216BE\u4e0d\u7b49\u6548\u7ed3\u679c\u6ca1\u6709\u4efb\u4f55\u4ef7\u503c,\u56e0\u4e3aLR+\u548c LR-\u65e0\u663e\u8457\u6027\u5dee\u5f02\u3002<\/span><\/p>\n

     <\/p>\n

    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n

    \n
    \n
    \n
    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/section>\n<\/section>\n
    \n
    \u8ba8\u8bba<\/span><\/strong><\/section>\n<\/section>\n
    \n
    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/section>\n<\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n

    BCS\u548cBDDCS\u5206\u7c7b\u4e2d\u7684BE\u4e0d\u7b49\u6548\u7ed3\u679c\u5206\u5e03\uff1a2\u7c7b\u6700\u9ad8<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    BE\u4e0d\u7b49\u6548\u7ed3\u679c\u5728BCS\u7c7b\u578b\u7684\u53d1\u751f\u7387\uff08\u8be6\u89c1Figure1\u548c Table2\uff09\u4e0e\u4e4b\u524d\u7684\u62a5\u544a\u76f8\u4f3c\u3002BE\u4e0d\u7b49\u6548\u7ed3\u679c\u53d1\u751f\u7387\u6700\u9ad8\u7684\u662f\u4f4e\u6eb6\u89e3\u3001\u9ad8\u6e17\u900f\u836f\u7269\u3002\u8be5\u7ed3\u679c\u5c5e\u9884\u6599\u4e4b\u4e2d\uff0c\u56e0\u4e3a\u6839\u636eBCS\u7406\u8bba\uff0c\u2161\u7c7b\u836f\u7269\u7684\u5438\u6536\u662f\u7531\u4f53\u5185\u836f\u7269\u6eb6\u89e3\u6216\u5176\u6eb6\u89e3\u5ea6\uff08\u5982\u9ad8\u5242\u91cf\u836f\u7269\u7070\u9ec4\u9709\u7d20\u7684\u4f8b\u5b50\uff09\u9650\u5236\u7684\uff0c\u8fd9\u610f\u5473\u7740\u662f\u836f\u7269\u6027\u8d28\u800c\u975e\u80c3\u6392\u7a7a\u65f6\u95f4\u6216\u80a0\u9053\u6e17\u900f\u6027\u51b3\u5b9a\u836f\u7269\u7684\u5438\u6536\u3002<\/span><\/p>\n


    <\/p>\n

    BCS\/BDDCS\u6bcf\u4e2a\u7c7b\u522b\u7684BE\u4e0d\u7b49\u6548\u5360\u6bd4\u5f88\u76f8\u4f3c\uff0c\u5373\u4f7f\u8fd9\u4e24\u4e2a\u7cfb\u7edf\u91c7\u7528\u4e0d\u540c\u7684\u4e34\u754c\u503c\u533a\u5206\u836f\u7269\u5438\u6536\u7a0b\u5ea6\uff1a BCS\u4e3a\u5438\u6536\u5927\u4e8e90%\uff0cBDCCS\u4e3a\u5927\u4e8e70%\u3002\u5b9e\u9645\u4e0a\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u836f\u7269\u7684\u4ee3\u8c22\u7387\u751a\u81f3\u4f4e\u4e8e\u7ed9\u836f\u5242\u91cf\u768470%\uff0c\u56e0\u4e3aBDCCS\u7684\u4ee3\u8c22\u6807\u51c6\u6ca1\u6709\u628a\u4ee3\u8c22\u8fc7\u7a0b\u9650\u5236\u4e3a\u6c27\u5316\u9176\uff08\u7b2c1\u9636\u6bb5\uff09\u548c\u805a\u5408\u9176\uff08\u7b2c2\u9636\u6bb5\uff09\u7684\u50ac\u5316\u53cd\u5e94\uff0c\u8fd9\u4e9b\u53cd\u5e94\u53ea\u662f\u53d1\u751f\u5728\u836f\u7269\u5438\u6536\u540e\uff0c\u800c\u5f88\u591a\u836f\u7269\u53ef\u88ab\u7ec6\u83cc\u9176\u7cfb\u4ee3\u8c22\uff0c\u53d1\u751f\u9996\u8fc7\u6548\u5e94\u3002<\/span><\/p>\n


    <\/span><\/p>\n

    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n

    BCS\u548cBDDCS\u6bcf\u4e2a\u7c7b\u522b\u7684BE\u4e0d\u7b49\u6548\u98ce\u9669\uff1a1,3\u7c7b\u76f8\u5f53<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u5f53\u6bd4\u8f83BCS\u6216BDDCS\u2160\u548c\u2162\u7c7b\u836f\u7269\u65f6\uff0c\u51fa\u73b0BE\u4e0d\u7b49\u6548\u548cBIE\u7684\u7ed3\u679c\u7684\u98ce\u9669\u51e0\u4e4e\u4e00\u81f4\u3002\u7136\u800c\uff0c\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u7531\u4e8e\u65e0\u6cd5\u5f97\u8db3\u591f\u7684\u6837\u672c\u91cf\uff0c\u672c\u6b21\u5206\u6790\u7684\u4e8c\u7c7b\u8bef\u5dee\u76f8\u5bf9\u8f83\u9ad8\uff08\u8fd170%\uff0cH0:\u03bcclass 1 =\u03bcclass 3\uff09\u3002\u76f8\u53cd\uff0c\u4e0e\u9ad8\u6eb6\u89e3\u836f\u7269\u76f8\u6bd4\uff0c\u4f4e\u6eb6\u89e3\u3001\u9ad8\u5438\u6536\u836f\u7269\u51fa\u73b0BE\u4e0d\u7b49\u6548\u6216BIE\u98ce\u9669\u9ad8\u51fa\u5c06\u8fd14\u500d\uff08\u8be6\u89c1Table 3\uff09\u3002\u7531\u4e8e\u4e24\u7ec4\u5bf9\u7167\u836f\u7269\uff08\u4e24\u4e2a\u7cfb\u7edf\u7684\u2160\u6216\u2162\u7c7bvs\u2161\u7c7b\uff09\u7684\u9884\u8ba1\u98ce\u9669\u76f8\u4f3c\uff0c\u6240\u4ee5\u6eb6\u89e3\u5ea6\u6bd4\u5438\u6536\u7a0b\u5ea6\u5bf9BE\u7ed3\u679c\u7684\u5f71\u54cd\u66f4\u5927\u3002\u4ee5\u4e0a\u7ed3\u679c\u6709\u52a9\u4e8e\u8bc4\u4f30\u751f\u7269\u7b49\u6548\u8c41\u514d\u7684\u8303\u56f4\u4e0d\u9650\u4e8eBCS\u2160\u7c7b\u836f\u7269\uff0c\u6b63\u5982Polli\u7b49\u4eba\u7684\u5efa\u8bae\u3002<\/span><\/p>\n

     <\/span><\/p>\n

    \u7136\u800c\uff0c\u4e0a\u8ff0\u5206\u6790\u7684\u6f5c\u5728\u7f3a\u70b9\u5728\u4e8eBCS\u5206\u7c7b\u57fa\u4e8e\u4ee5\u5047\u5b9a\u503c\u4f5c\u4e3a\u6e17\u900f\u6027\u7684\u6d4b\u5b9a\u65b9\u6cd5\u3002\u5047\u5b9a\u503c\u4f5c\u4e3a\u6e17\u900f\u6027\u5206\u7c7b\u5e76\u672a\u88ab\u4efb\u4f55\u751f\u7269\u7b49\u6548\u8c41\u514d\u6307\u5bfc\u539f\u5219\u4f5c\u4e3a\u6e17\u900f\u6027\u5206\u7c7b\u7684\u6807\u51c6\u6216\u751a\u81f3\u4e3a\u652f\u6301\u6761\u4ef6\u3002\u6240\u4ee5\u6682\u65f6\u57fa\u4e8e\u6eb6\u89e3\u5ea6\u548c\u5047\u5b9a\u503c\u7684BCS\u5206\u7c7b\u53ef\u80fd\u4f1a\u5927\u81f4\u5047\u9634\u6027\u7ed3\u679c\uff08\u5982\u6e17\u900f\u6027\u8bc4\u4f30\u76f8\u5173\u7684\u836f\u7269\u5e95\u7269\u5438\u6536\u6848\u4f8b\uff09\u3002\u76f8\u53cd\uff0c\u4eb2\u6cb9\u6027\u548c\u80a0\u9053\u6e17\u900f\u6027\u6709\u76f8\u5f53\u7d27\u5bc6\u7684\u5173\u8054\uff0c\u81f3\u5c11\u5bf9\u4e8e\u4e3b\u8981\u901a\u8fc7\u88ab\u52a8\u5438\u6536\u7684\u836f\u7269\u3002<\/span><\/p>\n


    <\/span><\/p>\n

    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n
    \n

    \u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u5bf9BE\u7ed3\u679c\u53ef\u9884\u6d4b\u6027-\u9ad8\u6eb6\u89e3\u836f\u7269\u7684\u8bca\u65ad\u53c2\u6570<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u8003\u8651\u5230\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u548cBE\u8bd5\u9a8c\u7684\u5bf9\u6bd4\u7ed3\u679c\u6709\u5dee\u5f02\uff0c\u53ef\u80fd\u9700\u8981\u57282*2\u5217\u8054\u8868\u4e2d\u8fdb\u884c\u6bd4\u8f83\u3002\u8bd5\u9a8c\u8868\u73b0\u6307\u6807\u6e90\u4e8e\u8bc4\u4f30\u4f53\u5916\u8bd5\u9a8c\u548c\u4f53\u5185\u8bd5\u9a8c\u7ed3\u679c\u53ef\u9884\u6d4b\u6027\u7684\u8868\u683c\uff08Table1\u548cTable 5\uff09\u3002<\/span><\/p>\n

     <\/span><\/p>\n

    \u5728\u4f53\u5916\u6eb6\u51fa\u5b9e\u9a8c\u4e2d\uff0c\u5355\u4e2a\u7c7b\u522b\u7684\u7075\u654f\u5ea6\u660e\u663e\u9ad8\u4e8e\u6240\u6709BCS\u6216BDDCS\u7c7b\u578b\uff0c75%-96%\u7684BE\u836f\u7269\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0e\u5176\u53c2\u6bd4\u836f\u7269\u76f8\u4f3c\uff0c\u7136\u800cBCS\u548cBDDCS\u2160\u548c\u2162\u7c7b\u836f\u7269\u7684\u7279\u5f02\u6027\u5728\u7edf\u8ba1\u6570\u636e\u4e0a\u5e76\u4e0d\u663e\u8457\u3002\u6362\u800c\u8a00\u4e4b\uff0c50%\u7684BE\u4e0d\u7b49\u6548\u836f\u7269\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4e0d\u76f8\u4f3c\uff0c\u800c\u53e6\u591650%\u7684\u4f53\u5916\u7ed3\u679c\u76f8\u4f3c\u3002\u7136\u800c\uff0c\u57fa\u4e8eBCS\u7684\u751f\u7269\u7b49\u6548\u9700\u8981\u7684\u662f\u4e0d\u6b62\u4e00\u6761\u800c\u662f\u4e00\u7ec4\u4e09\u6761\u5728PH\u4e0e\u4e0a\u6d88\u5316\u9053\u76f8\u4f3c\u7684\u6761\u4ef6\u4e0b\u5f97\u51fa\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\uff0c\u8fd9\u53ef\u4ee5\u88ab\u7406\u89e3\u4e3a\u4e00\u7cfb\u5217\u5206\u6790\u8bd5\u9a8c\uff0c\u56e0\u4e3a\u7b2c\u4e00\u4e2a\u7ed3\u679c\u51b3\u5b9a\u7b2c\u4e8c\u4e2a\u8bd5\u9a8c\u662f\u5426\u8fdb\u884c\u3002\u4f8b\u5982\uff1a\u5982\u679c\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u5728PH1.2\u65f6\u76f8\u4f3c\uff0c\u90a3\u4e48\u7b2c\u4e8c\u4e2a\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u5c31\u5728PH4.5\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0c\u5982\u679c\u4e5f\u76f8\u4f3c\uff0c\u7b2c\u4e09\u4e2a\u8bd5\u9a8c\u5c31\u5728PH6.8\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\u3002\u6839\u636e\u751f\u7269\u7b49\u6548\u8c41\u514d\u8fc7\u7a0b\uff0c\u53ea\u6709\u4e09\u4e2a\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u90fd\u76f8\u4f3c\uff0c\u836f\u7269\u624d\u80fd\u88ab\u6279\u51c6\uff0c\u5426\u5219\u5224\u5b9a\u65e0\u6548\u3002\u8fd9\u79cd\u591a\u91cd\u68c0\u9a8c\u7ed3\u5408\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6574\u4f53\u7279\u5f02\u6027\u6bd4\u5355\u4e2a\u4f53\u5916\u8bd5\u9a8c\u66f4\u9ad8\u3002\u8003\u8651\u5230\u672c\u6b21\u8c03\u7814\u7684\u8bca\u65ad\u53c2\u6570\u4ee5\u5355\u4e2a\u4f53\u5916\u8bd5\u9a8c\u7ed3\u679c\u8ba1\u7b97\uff0c\u6eb6\u51fa\u8bd5\u9a8c\u5728\u836f\u5178\u6216\u751f\u4ea7\u9a8c\u8bc1\u7684\u6761\u4ef6\u4e0b\u8bc4\u4f30\u8d28\u91cf\u63a7\u5236\uff0c\u5f53\u8fdb\u884c\u652f\u6301\u751f\u7269\u7b49\u6548\u8c41\u514d\u7684\u6574\u5957\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u8bd5\u9a8c\u65f6\uff0c\u8bd5\u9a8c\u51c6\u786e\u6027\u8d8a\u9ad8\u4f3c\u4e4e\u8d8a\u5b89\u5168\u3002<\/span><\/p>\n

     <\/span><\/p>\n

    BCS \u2162\u7c7b\u836f\u7269\u7684\u5438\u6536\u6bd4\u2160\u7c7b\u836f\u7269\u66f4\u590d\u6742\uff0c\u56e0\u4e3a\u5b83\u7684\u5438\u6536\u90e8\u5206\u4f9d\u8d56\u4e8e\u5c0f\u80a0\uff0c\u5e76\u7531\u6444\u53d6\u6027\u8fd0\u8f7d\u4f53\u4f20\u9012\u3002\u56e0\u6b64\uff0c\u2162\u7c7b\u836f\u7269\u7684\u5438\u6536\u66f4\u53d7\u90e8\u5206\u8f85\u6599\u5f71\u54cd\uff0c\u4e0e\u80c3\u80a0\u8815\u52a8\u76f8\u4e92\u4f5c\u7528\uff0c\u964d\u4f4e\u80a0\u8f6c\u9001\u65f6\u95f4\uff0c\u8fd8\u53ef\u80fd\u4e0e\u6444\u53d6\u6027\u8fd0\u8f7d\u4f53\u76f8\u4e92\u4f5c\u7528\u3002\u7531\u4e8e\u5df4\u897f\u6cd5\u5f8b\u4e0d\u8981\u6c42\u4eff\u5236\u836f\u548c\u53c2\u6bd4\u5236\u5242\u7684\u5904\u65b9\u8d28\u4e0e\u91cf\u7684\u76f8\u4f3c\uff0c\u56e0\u6b64\u4eff\u5236\u836f\u7684\u8f85\u6599\u548c\u7528\u91cf\u4e00\u822c\u6709\u5dee\u5f02\u3002\u7531\u4e8e500\u4e2a\u6837\u672c\u836f\u7269\u7684\u5904\u65b9\u4e0e\u53c2\u6bd4\u5236\u5242\u5904\u65b9\u672a\u505a\u6bd4\u8f83\uff0c\u6211\u4eec\u65e0\u6cd5\u6392\u9664\u4eff\u5236\u836f\u4e0d\u540c\u8f85\u6599\u5f71\u54cd\u819c\u8f7d\u4f53\u6216\u80a0\u80c3\u8815\u52a8\u7684\u53ef\u80fd\uff0c\u5bfc\u81f4\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u65e0\u6cd5\u9884\u6d4b\u7684BE\u4e0d\u7b49\u6548\u7ed3\u679c\u3002\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u2162\u7c7b\u836f\u7269\u7684\u9884\u540e\u6982\u7387\u4f4e\u4e8e\u2160\u7c7b\u836f\u7269\uff0827% vs71%\uff09\u3002\u8fd9\u4e2a\u89c2\u70b9\u9700\u8981\u66f4\u591a\u7684\u8bd5\u9a8c\u6765\u8fdb\u4e00\u6b65\u8bc1\u660e\u3002\u7136\u800c\uff0c\u7531\u4e8e\u2162\u7c7b\u836f\u7269\u51fa\u73b0BE\u4e0d\u7b49\u6548\u7ed3\u679c\u7684\u98ce\u9669\u8f83\u4f4e\uff0c\u56e0\u6b64\uff0c\u6839\u636eEMA\u6307\u5357\uff0c\u5728\u8f85\u6599\u6210\u5206\u4e0e\u53c2\u6bd4\u5236\u5242\u76f8\u540c\u7684\u60c5\u51b5\u4e0b\uff0cBE\u8c41\u514d\u8303\u56f4\u653e\u5bbd\u81f3\u9ad8\u6eb6\u89e3\u3001\u4f4e\u5438\u6536\u4eff\u5236\u836f\u662f\u76f8\u5bf9\u5b89\u5168\u7684\u3002<\/span><\/p>\n


    <\/span><\/p>\n

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    BSC \u2162\u7c7b\u836f\u7269\u751f\u7269\u7b49\u6548\u8c41\u514d\u7684\u5feb\u901f\u6eb6\u51favs \u975e\u5e38\u5feb\u901f\u6eb6\u51fa<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    BSC\u2162\u7c7b\u836f\u7269\u7684\u5224\u5b9a\u6307\u6807\u91c7\u7528\u4e24\u4e2a\u6eb6\u51fa\u6807\u51c6\u8ba1\u7b97\uff0c\u5feb\u901f\u6eb6\u51fa\uff0830\u5206\u949f\u5185\uff0cQ>85\uff0cf2\u76f8\u4f3c\uff09<\/span> vs \u975e\u5e38\u5feb\u901f\u6eb6\u51fa\uff0815\u5206\u949f\uff0cQ>85\uff0c\u65e0\u9700 f2\uff09<\/span>\u3002\u7531\u4e8e\u4e24\u79cd\u6eb6\u51fa\u6807\u51c6\u7684\u5224\u5b9a\u53c2\u657095%\u7f6e\u4fe1\u533a\u95f4\u51e0\u4e4e\u5b8c\u5168\u91cd\u5408\uff08\u8be6\u89c1Table 5\uff09\uff0cBE\u7ed3\u679c\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u53ef\u9884\u6d4b\u6027\u5e76\u6ca1\u6709\u56e0\u91c7\u7528\u66f4\u4e25\u683c\u7684\u6eb6\u51fa\u6807\u51c6\u800c\u63d0\u9ad8\u3002\u800c\u4e14\uff0c\u8fd9\u79cd\u65b9\u6cd5\u589e\u52a0\u4e86\u5047\u9634\u6027\u7ed3\u679c\u7684\u53ef\u80fd\u6027\uff081-\u7075\u654f\u5ea6\uff0c\u4ece8%\u589e\u81f325%\uff09\uff0c\u964d\u4f4e\u4e86non-BE\u7ed3\u679c\u7684\u9a8c\u540e<\/span>\u6982\u7387\uff08\u4ece27%\u964d\u81f322%\uff09\u3002\u4e4b\u524d\u7684\u62a5\u544a\u5df2\u7ecf\u8bf4\u660e\u751f\u7269\u7b49\u6548\u8c41\u514d\u7684\u6807\u51c6\u5bf9\u4e8e\u975e\u5e38\u5feb\u901f\u6eb6\u7684BSC\u2162\u7c7b\u53e3\u670d\u836f\u7269\u5236\u5242\u8fc7\u4e8e\u4fdd\u5b88\u3002<\/span><\/span><\/p>\n

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    \u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u5bf9BE\u7ed3\u679c\u53ef\u9884\u6d4b\u6027–\u2161\u7c7b\u836f\u7269\u7684\u8bca\u65ad\u53c2\u6570<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u2161\u7c7b\u836f\u7269\u4f53\u5916\u8bd5\u9a8c\u5448\u5047\u9633\u6027\u7ed3\u679c\u7684\u53ef\u80fd\u6027\u5c06\u8fd190%\uff0c\u663e\u793a\u7279\u5f02\u602790%\u7f6e\u4fe1\u533a\u95f4\u6709\u663e\u8457\u7684\u7edf\u8ba1\u610f\u4e49\uff0c\u610f\u5473\u7740\u836f\u5178\u6eb6\u51fa\u65b9\u6cd5\u4e0d\u662f\u751f\u7269\u76f8\u5173\u7684\u3002\u6b64\u5916\uff0c\u7531\u4e8e95%\u7f6e\u4fe1\u533a\u95f4\u5177\u6709\u7edf\u4e00\u6027\uff0cLR+\u548cLR-\u7f3a\u4e4f\u8bca\u65ad\u4ef7\u503c\uff0c\u56e0\u6b64\uff0c\u9a8c\u540e<\/span>\u6982\u7387\u7b49\u4e8e\u9a8c\u524d\u6982\u7387\uff1b\u6362\u800c\u8a00\u4e4b\uff0c\u6839\u636e\u836f\u5178\u7684\u65b9\u6cd5\u6d4b\u5f97\u7684\u7528\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u5bf9BE\u7ed3\u679c\u9884\u6d4b\u6027\u4e0eBE\u7b49\u6548\u6216BE\u4e0d\u7b49\u6548\u7684\u6982\u7387\u4e0d\u4e00\u81f4\uff08\u89c1Table 5\uff09\u3002\u53e6\u5916\uff0c\u7531\u4e8e\u6211\u4eec\u6ca1\u6709\u57fa\u4e8eBCS\u751f\u7269\u7b49\u6548\u8c41\u514d\u6307\u5357\u83b7\u5f97\u8fd9\u4e9b\u836f\u7269\uff08BCS \u2161\u7c7b\uff09\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\uff0c\u56e0\u6b64\u5b83\u4eec\u7684\u53ef\u9884\u6d4b\u6027\u6682\u65e0\u7ed3\u8bba\u3002<\/span><\/span><\/p>\n

    <\/span><\/p>\n

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    \u9ad8\u6e17\u900f\u5f31\u9178\u6027\u836f\u7269\u7684\u8bca\u65ad\u6307\u6807\u5728PH6.8\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u9ad8\u6eb6\u89e3\u5ea6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u7531\u4e8eWHO\u5efa\u8bae\u57fa\u4e8eBCS\u7684\u751f\u7269\u7b49\u6548\u8c41\u514d\u8303\u56f4\u653e\u5bbd\u81f3PH6.8\u6761\u4ef6\u4e0b\u9ad8\u6eb6\u89e3\u3001\u5feb\u901f\u6eb6\u51fa\u7684\u2161\u7c7b\u836f\u7269\uff0c\u6211\u4eec\u8fd8\u5229\u7528\u5728\u4e2d\u6027\u6761\u4ef6\uff08\u78f7\u9178\u76d0\u7f13\u51b2\u6db2\u4f4e\u4e8ePH6.8-7.5\uff09\u4e0b\u768422\u4e2a\u836f\u7269\u7684\u4f53\u5916\u6eb6\u51fa\u66f2\u7ebf\u4f5c\u4e3a\u8ba1\u7b97\u5224\u5b9a\u6307\u6807\uff0c\u5206\u6790\u4e868\u4e2aBE\u4e0d\u7b49\u6548\u548c14\u4e2aBE\u7b49\u6548\u836f\u7269\uff0c\u5176\u4e2d\u5305\u62ec5\u4e2apKa\u5c0f\u4e8e5.5\u7684\u5f31\u9178\u6027\u836f\u7269\u4e14\u5242\u91cf\u4f4e\u4e8ePH6.8-7.4\u6761\u4ef6\u4e0b\u7684\u5242\u91cf\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u8bca\u65ad\u53c2\u6570\u88ab\u8bc1\u660e\u5e76\u975e\u4e0d\u540c\u4e8eBSC\u2161\u7c7b\u836f\u7269\u8ba1\u7b97\u6240\u5f97\u503c\uff0c\u6839\u636e\u4e4b\u524d\u5e03\u6d1b\u82ac\u7684\u836f\u7269\u62a5\u544a\u663e\u793a\uff1a\u4e2d\u6027\u6761\u4ef6\u4e0b\u7684\u7684\u6eb6\u51fa\u8bd5\u9a8c\u4e00\u65b9\u9762\u4e0d\u80fd\u5206\u8fa8\u51fa\u5438\u6536\u7387\u7684\u5dee\u5f02\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u4f53\u5185\u7b49\u6548\u6848\u4f8b\u8fc7\u5206\u533a\u5206\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5f31\u9178\u6027\u836f\u7269\u5728\u80c3\u91cc\u6eb6\u51fa\u6216\u8bb8\u80fd\u533a\u5206Cmax\u5728\u4f53\u5185\u7684\u5dee\u5f02\uff0c\u4f46\u836f\u7269\u6eb6\u51fa\u4f4e\u6392\u9664\u4e86f2\u6570\u636e\u7684\u7edf\u8ba1\u3002\u6700\u8fd1\uff0c\u4e00\u4e9b\u4e13\u5bb6\u5efa\u8bae\u4f7f\u7528f2\u6570\u636e\u4e4b\u524d\u5c06\u6570\u636e\u6269\u5927\u5230\u53c2\u6bd4\u5236\u5242\u7684100%\u91ca\u653e\uff08\u7531\u4e8ef2\u4ee3\u8868\u7edd\u5bf9\u5dee\u5f02\u800c\u975e\u76f8\u5bf9\u5dee\u5f02\uff09\u3002\u7136\u800c\uff0c\u8fd9\u4e2a\u9886\u57df\u7684\u8ba8\u8bba\u624d\u521a\u5f00\u59cb\uff0c\u9ad8\u6e17\u900f\u5f31\u9178\u6027\u836f\u7269\u6eb6\u51fa\u6570\u636e\u5904\u7406\u7684\u6700\u4f73\u65b9\u5f0f\u4ecd\u9700\u8fbe\u6210\u4e00\u81f4\u3002<\/span><\/p>\n

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    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/section>\n<\/section>\n
    \n
    \u7ed3\u8bba<\/span><\/strong><\/section>\n<\/section>\n
    \n
    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u901a\u8fc7\u73b0\u51b5\u8c03\u67e5\uff0c\u6211\u4eec\u53d1\u73b0\u6eb6\u89e3\u6027\u5bf9BE\u7ed3\u679c\u7684\u5f71\u54cd\u8fdc\u5927\u4e8e\u836f\u7269\u5438\u6536\u7a0b\u5ea6\uff0c\u65e0\u8bba\u662f\u80a0\u9053\u6e17\u900f\u6027\u8fd8\u662f\u836f\u7269\u4ee3\u8c22\u7a0b\u5ea6\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u4e24\u4e2a\u7cfb\u7edf\u7684\u2160\u3001\u2162\u7c7b\u4e0e\u2161\u7c7b\u5bf9\u6bd4\u7684\u8bc4\u4f30\u98ce\u9669\u76f8\u4f3c\uff0c\u56e0\u6b64BDDCS\u88ab\u8ba4\u4e3a\u7b49\u540c\u4e8eBCS\u4f5c\u4e3a\u751f\u7269\u8c41\u514d\u7684\u836f\u54c1\u5206\u7c7b\u7cfb\u7edf\u3002\u5728\u4e00\u4e9b\u6848\u4f8b\u4e2d\uff0c\u836f\u7269\u4ee3\u8c22\u6570\u636e\u6bd4\u6e17\u900f\u6027\u6570\u636e\u66f4\u6613\u83b7\u53d6\uff1b\u7528\u4f5c\u76d1\u7ba1\u76ee\u7684\u7684\u4e24\u79cd\u836f\u54c1\u5206\u7c7b\u65b9\u6cd5\u90fd\u662f\u6709\u6548\u7684\u3002\u800c\u4e14\uff0c\u7531\u4e8e\u2162\u7c7b\u836f\u7269\u51fa\u73b0BE\u4e0d\u7b49\u6548\u6216BIE\u7684\u98ce\u9669\u4e00\u822c\u8f83\u4f4e\uff0c\u751f\u7269\u8c41\u514d\u8303\u56f4\u653e\u5bbd\u81f3\u9ad8\u6eb6\u89e3\u3001\u4f4e\u5438\u6536\u7684\u4eff\u5236\u836f\u53ef\u80fd\u662f\u5b89\u5168\u7684\uff0c\u53ea\u8981\u5b83\u4eec\u91c7\u7528\u4e0e\u53c2\u6bd4\u5236\u5242\u76f8\u540c\u4e14\u7b49\u91cf\u7684\u8f85\u6599\u8fdb\u884c\u5236\u5907\u3002\u76f8\u53cd\uff0c\u2161\u7c7b\u836f\u7269\u7531\u4e8e\u51fa\u73b0BE\u4e0d\u7b49\u6548\u6216BIE\u7684\u98ce\u9669\u8f83\u9ad8\uff0c\u4e14LR+\u548cLR-\u5728\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u7684\u8d28\u91cf\u63a7\u5236\u4e2d\u7f3a\u5c11\u501f\u9274\u4f5c\u7528\uff0c\u6545\u751f\u7269\u7b49\u6548\u8c41\u514d\u653e\u5bbd\u2161\u7c7b\u836f\u7269\u5230\u4ecd\u5f85\u8003\u8bc1\u3002<\/span><\/p>\n

    <\/span><\/p>\n

    \n

    \u539f\u6587\u9898\u76ee\uff1aA Comparative Analysis of Biopharmaceutics Classification System and Biopharmaceutics Drug Disposition Classification System: A Cross-Sectional Survey with 500 Bioequivalence Studies,\u539f\u6587\u4f5c\u8005\uff1aCristofoletti R, Chiann C, Dressman JB, Storpirtis S\uff0c\u539f\u53d1\u671f\u520a\uff1aJ Pharm Sci<\/span>
    <\/p>\n

    \u3010\u8f6c\u81ea\uff1a\u836f\u4e8b\u7eb5\u6a2a\u3011<\/strong><\/p>\n

    \n
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    \"\u57f9\u4f18BE\u7cfb\u521713\u2014\u2014500\u836f\u7269\u7684BE\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8868\u660e:BCS2\u7c7b\u836fBE\u98ce\u9669\u6700\u5927\uff0cBCS<\/p>\n<\/section>\n<\/section>\n

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    \u514d\u8d23\u58f0\u660e\uff1a<\/span><\/p>\n

    \u672c\u6587\u4fe1\u606f\u90e8\u5206\u5185\u5bb9\u6765\u81ea\u7f51\u7edc\u6587\u7ae0\uff0c\u4e0d\u4fdd\u8bc1\u6240\u6709\u4fe1\u606f\u3001\u6587\u672c\u3001\u56fe\u5f62\u3001\u94fe\u63a5\u53ca\u5176\u4ed6\u9879\u76ee\u7684\u7edd\u5bf9\u51c6\u786e\u6027\u548c\u5b8c\u6574\u6027\uff0c\u6545\u4ec5\u4f9b\u8bbf\u95ee\u8005\u53c2\u7167\u9002\u7528\u3002\u5982\u60a8\uff08\u5355\u4f4d\u6216\u4e2a\u4eba\uff09\u8ba4\u4e3a\u672c\u6587\u67d0\u90e8\u5206\u5185\u5bb9\u6709\u4fb5\u6743\u5acc\u7591\uff0c\u656c\u8bf7\u7acb\u5373\u901a\u77e5\u6211\u4eec\uff0c\u6211\u4eec\u5c06\u5728\u7b2c\u4e00\u65f6\u95f4\u4e88\u4ee5\u66f4\u6b63\u6216\u5220\u9664\u3002\u4ee5\u4e0a\u58f0\u660e\u4e4b\u89e3\u91ca\u6743\u5f52\u672c\u516c\u4f17\u53f7\u6240\u6709\u3002\u6cd5\u5f8b\u4e0a\u6709\u76f8\u5173\u89e3\u91ca\u7684\uff0c\u4ee5\u4e2d\u56fd\u6cd5\u5f8b\u4e4b\u89e3\u91ca\u4e3a\u57fa\u51c6\u3002\u5982\u6709\u4e89\u8bae\u9650\u5728\u6211\u65b9\u6240\u5728\u5730\u53f8\u6cd5\u90e8\u95e8\u89e3\u51b3\u3002\u8c22\u8c22\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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    \u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u57f9\u4f18\u521b\u65b0\u8bba\u575b <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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