{"id":15266,"date":"2018-07-21T01:00:00","date_gmt":"2018-07-30T04:30:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/30\/%e3%80%90bioworld-science%e3%80%912018%e5%b9%b46%e6%9c%88%e8%8d%af%e7%89%a9%e5%bf%ab%e8%ae%af-%e5%b8%ae%e5%8a%a9%e6%82%a8%e5%8f%8a%e6%97%b6%e6%8a%8a%e6%8f%a1%e8%8d%af%e7%89%a9%e7%a0%94\/"},"modified":"2018-07-30T12:30:27","modified_gmt":"2018-07-30T04:30:27","slug":"%e3%80%90bioworld-science%e3%80%912018%e5%b9%b46%e6%9c%88%e8%8d%af%e7%89%a9%e5%bf%ab%e8%ae%af-%e5%b8%ae%e5%8a%a9%e6%82%a8%e5%8f%8a%e6%97%b6%e6%8a%8a%e6%8f%a1%e8%8d%af%e7%89%a9%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/15266\/","title":{"rendered":"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\">\u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb<\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 14px;color: rgb(104, 23, 255);\"><strong><span style=\"line-height: 14.98px;font-size: 14px;background-color: rgb(255, 255, 255);\">Drug Daily News\u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science<\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"margin-left: 0.8em;float: left;box-sizing: border-box;\">\n<section class=\"\" style=\"width: 2.5em;display: inline-block;vertical-align: bottom;box-sizing: border-box;overflow: hidden !important;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532925026.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/section>\n<section class=\"\" style=\"margin-top: 0.5em;display: inline-block;vertical-align: top;font-size: 24px;box-sizing: border-box;\">\n<p style=\"clear: none;box-sizing: border-box;\"><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\">\u5feb\u901f<\/span><\/strong><\/span><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\">\u5bfc\u89c8<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<p><img class=\"\"     width=\"100%\" style=\"width: 558px;float: left;display: inline-block;vertical-align: middle;background-color: rgb(166, 91, 203);box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532925026.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<section class=\"\" style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(62, 62, 62);\"><\/span><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u65b0\u836f\u8bc4\u5ba1 &amp; \u7279\u6b8a\u8d44\u683c\u8ba4\u5b9a<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670822\u65e5\uff0cFDA\u6279\u51c6\u4e86lanifibranor\u7528\u4e8e\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\u7684IND\u7533\u8bf7<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<\/li>\n<\/ul>\n<\/section>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u6297\u80bf\u7624\u836f\u7269<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/h2>\n<h2 style=\"white-space: normal;text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(91, 155, 213);\"><\/span><\/h2>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;\">2018\u5e746\u67081\u65e5\uff0c\u7814\u7a76\u8868\u660eGNMT\u6709\u671b\u4f5c\u4e3a\u5c3f\u8def\u4e0a\u76ae\u764c\u548c\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u9776\u6807<\/span><\/h2>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u67085\u65e5\uff0c\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u53ca\u5408\u4f5c\u8005\u5408\u6210\u4e86\u9776\u5411MALT1\u7684\u5316\u5408\u7269<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670812\u65e5\uff0c\u9ed8\u514b\u53d1\u8868tepotinib\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8aII\u671f\u6570\u636e<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670820\u65e5\uff0cACY-1215\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670820\u65e5\uff0cCan-Fite\u516c\u53f8\u53d1\u5e03namodenoson\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684II\u671f\u4e34\u5e8a\u6570\u636e<\/span><\/p>\n<\/li>\n<p><br  \/><\/p>\n<\/ul>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;\">2018\u5e746\u67085\u65e5\uff0c\u9ad8\u7ea7\u522b\u8180\u80f1\u764c\u5c0f\u9f20\u6a21\u578b\u53ef\u7528\u6765\u9a8c\u8bc1\u514d\u75ab\u7597\u6cd5\u7684\u6709\u6548\u6027<\/span><\/h2>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong>\u4ee3\u8c22\u7c7b\u75be\u75c5<\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong><br  \/><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/h2>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u67085\u65e5\uff0cGS-0976\u5bf9NASH\u809d\u786c\u5316\u60a3\u8005\u8868\u73b0\u51fa\u663e\u8457\u7597\u6548<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u67087\u65e5\uff0cS1P\u5bf9\u9aa8\u8d28\u91cf\u7684\u8c03\u8282\u8d77\u5230\u5173\u952e\u4f5c\u7528\uff0c\u6216\u6210\u4e3a\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u7684\u9776\u6807<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670827\u65e5\uff0c\u4e2d\u5916\u5236\u836f\u62a5\u9053\u53e3\u670d\u6709\u6548\u7684\u975e\u80bd\u7c7bGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242OWL-833<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong>\u6297\u611f\u67d3\u836f\u7269<\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong><br  \/><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670812\u65e5\uff0c\u9776\u5411HIV-1\u878d\u5408\u80bd\u7684\u4e2d\u548c\u6297\u4f53\u6709\u671b\u4f5c\u4e3a\u75ab\u82d7\u7814\u53d1\u7684\u65b0\u7b56\u7565<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u5fc3\u8840\u7ba1\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<h2><span style=\"font-size: 14px;\">2018\u5e746\u670820\u65e5\uff0cIdorsia\u516c\u53f8\u5f00\u5c55aprocitentan\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u9ad8\u8840\u538b\u7684\u4e34\u5e8aIII\u671f\u8bd5\u9a8c<\/span><\/h2>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong>\u8840\u6db2\u4e0e\u51dd\u8840\u7cfb\u7edf\u75be\u75c5<\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/h2>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;\">2018\u5e746\u67081\u65e5\uff0cAstellas\u4e0eFibroGen\u8054\u5408\u53d1\u5e03roxadustat\u65e5\u672c\u4e34\u5e8aIII\u671f\u7814\u7a76\u7684\u5173\u952e\u6027\u6570\u636e<\/span><\/h2>\n<\/li>\n<\/ul>\n<h2 style=\"white-space: normal;\"><\/h2>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong>\u6297\u708e\u75c7\u836f\u7269<\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong><br  \/><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u670825\u65e5\uff0cAZD-9567\u7684\u4f53\u5185\u53ca\u4e34\u5e8a\u7597\u6548\u5747\u4f18\u4e8eprednisolone<\/span><\/p>\n<\/li>\n<p><br  \/><\/p>\n<\/ul>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<section class=\"\" style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(166, 91, 203);box-sizing: border-box;border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;\"><\/span>&nbsp;<\/section>\n<section class=\"\" style=\"padding-left: 3px;display: inline-block;vertical-align: top;line-height: 1.2;box-sizing: border-box;\">\n<p style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"font-size: 14px;\"><strong>\u7cbe\u795e\u7c7b\u75be\u75c5<\/strong><\/span><\/p>\n<\/section>\n<p><br  \/><\/p>\n<p><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p><span style=\"font-size: 14px;\">2018\u5e746\u67081\u65e5\uff0c\u9ed8\u514b\u516c\u53f8\u53d1\u73b0alpha7\u53d7\u4f53\u7684\u6b63\u5411\u53d8\u6784\u8c03\u8282\u5242<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">1<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;font-size: 21px;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u65b0\u836f\u8bc4\u5ba1 &amp; \u7279\u6b8a\u8d44\u683c\u8ba4\u5b9a<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"font-size: 14px;color: rgb(104, 23, 255);\"><strong><span style=\"line-height: 14.98px;font-size: 14px;background-color: rgb(255, 255, 255);\">2018\u5e746\u670822\u65e5\uff0cFDA\u6279\u51c6\u4e86lanifibranor\u7528\u4e8e\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\u7684IND\u7533\u8bf7<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\">FDA\u65e5\u524d\u6279\u51c6\u4e86Inventiva\u516c\u53f8\u7684lanifibranor\u7528\u4e8e\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\uff08NAFLD\uff09\u7684\u4e34\u5e8aII\u671fIND\u7533\u8bf7\u3002\u8fd9\u9879\u8bd5\u9a8c\u5c06\u5728\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u76d6\u6069\u65af\u7ef4\u5c14\u5206\u6821\u8fdb\u884c\uff0c\u9884\u8ba1\u5c06\u7eb3\u516564\u540d\u53d7\u8bd5\u8005\u63a5\u53d7\u4e3a\u671f24\u5468\u7684\u6cbb\u7597\uff0c\u5242\u91cf\u4e3a\u6bcf\u65e5\u4e00\u6b21800\u6beb\u514b\u6216\u5b89\u6170\u5242\uff1b\u53e6\u670910\u540d\u5065\u5eb7\u975e\u80a5\u80d6\u7684\u53d7\u8bd5\u8005\u63a5\u53d7\u5bf9\u7167\u7ec4\u7814\u7a76\u3002\u8fd9\u9879\u7814\u7a76\u7684\u603b\u4f53\u76ee\u6807\u662f\u6d4b\u8bd5lanifibranor\u5f15\u8d77\u7684\u4ee3\u8c22\u6027\u6539\u5584\u4ee5\u53ca\u5b83\u5bf92\u578b\u7cd6\u5c3f\u75c5\u548cNAFLD\u60a3\u8005\u8102\u80aa\u53d8\u6027\u7684\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u8fd9\u9879\u7814\u7a76\u5c06\u5229\u7528\u6700\u65b0\u7684\u5f71\u50cf\u5b66\u548c\u751f\u7269\u6807\u5fd7\u7269\u6280\u672f\u6765\u68c0\u6d4blanifibranor\u5bf9\u7ea4\u7ef4\u5316\u7684\u5f71\u54cd\u3002\u5b83\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u901a\u8fc7\u5f71\u50cf\u5b66\u8bc4\u4f30\u809d\u8102\u80aa\u53d8\u6027\u7684\u51cf\u5c11\uff0c\u5305\u62ecH-MRS\uff08\u8d28\u5b50\u78c1\u5171\u632f\u5149\u8c31\u5b66\uff09\uff0c\u4ee5\u53ca\u80f0\u5c9b\u7d20\u62b5\u6297\u7684\u964d\u4f4e\uff08\u8461\u8404\u7cd6\u94b3\u5939\u6280\u672f\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff09\u3001\u65b0\u751f\u8102\u80aa\u7684\u51cf\u5c11\u53ca\u5b89\u5168\u6027\u3002\u9996\u4f8b\u75c5\u4eba\u9884\u8ba1\u5c06\u5728\u4eca\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5165\u7ec4\uff0c\u5173\u952e\u6027\u7ed3\u679c\u9884\u8ba1\u57282020\u5e74\u521d\u53d1\u5e03\u3002Inventiva\u516c\u53f8\u8fd8\u8ba1\u5212\u4e3a\u7cfb\u7edf\u6027\u786c\u5316\u75c7\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u9002\u5e94\u75c7\u63d0\u4ea4IND\u7533\u8bf7\u3002\uff08Inventiva\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532925026.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">\u56fe\u4e3a<span style=\"font-size:14px;line-height:107%;color:#404040;\">Lanifibranor<\/span>\u7ed3\u6784<\/span><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">&nbsp;<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 19.2px;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">2<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;font-size: 21px;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u6297\u80bf\u7624\u836f\u7269<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><br  \/><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u67081\u65e5\uff0c\u7814\u7a76\u8868\u660eGNMT\u6709\u671b\u4f5c\u4e3a\u5c3f\u8def\u4e0a\u76ae\u764c\u548c\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u9776\u6807<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u7518\u6c28\u9178N-\u7532\u57fa\u8f6c\u79fb\u9176\uff08GNMT\uff09\u5728\u7cd6\u5f02\u751f\u548c\u7532\u786b\u6c28\u9178\u4ee3\u8c22\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u6700\u8fd1\u6709\u62a5\u9053\u79f0GNMT\u662f\u4e00\u79cd\u764c\u57fa\u56e0\uff0c\u800c\u6b64\u524d\u5f88\u5c11\u6709\u4eba\u77e5\u9053\u5b83\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u548c\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u7684\u81f4\u764c\u548c\u80bf\u7624\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u89c2\u5bdf\u5230GNMT\u5728RCC\u7ec6\u80de\u7cfb\uff0c\u5c24\u5176\u662f\u9ad8\u7ea7\u7ec6\u80de\u7cfbSKR1\u4e2d\u8fc7\u8868\u8fbe\u3002\u514d\u75ab\u7ec4\u5316\u7ed3\u679c\u663e\u793aGNMT\u86cb\u767d\u5728UC\u548cRCC\u7684\u7ec6\u80de\u8d28\u4e2d\u8868\u8fbe\u3002\u5f53GNMT\u88absiRNA\u6280\u672f\u6572\u9664\u540e\uff0c\u53ea\u6709\u5c11\u91cf\u7684\u764c\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de\u51fa\u73b0\u589e\u6b96\uff0c\u800c\u5728UC\u9ad8\u7ea7\u7ec6\u80de\u7cfbSKR1\u548cKK47\u4e2d\u89c2\u5bdf\u5230\u9ad8\u589e\u6b96\u6291\u5236\u3002GNMT\u7684\u6572\u9664\u4e5f\u5bfc\u81f4\u4e86sub-G1\u671f\u7ec6\u80de\u5206\u6570\u7684\u589e\u52a0\uff0c\u8868\u660e\u7ec6\u80de\u6b7b\u4ea1\u7684\u6bd4\u4f8b\u63d0\u9ad8\u3002\u8fd9\u4e9b\u6570\u636e\u63d0\u793a\uff0cGNMT\u6709\u671b\u4f5c\u4e3a\u6cbb\u7597UC\u548cRCC\u7684\u6f5c\u5728\u9776\u70b9\u3002\uff08Takeuchi,A. et al. 113th Annu Meet Am UrolAssoc (AUA) (May 18-21, San Francisco) 2018,Abst MP88-19\uff09\u3002<\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"font-size:14px;color:#404040;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><o:p><\/o:p><\/p>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\"><\/span><\/strong><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u67085\u65e5\uff0c\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u53ca\u5408\u4f5c\u8005\u5408\u6210\u4e86\u9776\u5411MALT1\u7684\u5316\u5408\u7269<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff0c\u5eb7\u5948\u5c14\u5927\u5b66\u548c\u513f\u7ae5\u533b\u5b66\u4e2d\u5fc3\u516c\u53f8\u65e5\u524d\u53d1\u8868\u4e86\u4e00\u7cfb\u5217\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u4f53\uff08PROTAC\uff09\u5316\u5408\u7269\uff0c\u80fd\u591f\u6291\u5236\u9ecf\u819c\u76f8\u5173\u6dcb\u5df4\u7ec4\u7ec7\u6dcb\u5df4\u7624\u6613\u4f4d\u86cb\u767d1\uff08MALT1\uff09\u5e76\u4fc3\u8fdbMALT1\u7684\u9776\u5411\u6cdb\u7d20\u5316\u4ece\u800c\u4f7f\u4e4b\u964d\u89e3\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3002\u8fd9\u4e9b\u5316\u5408\u7269\u5305\u62ec\u4e00\u4e2aE3\u6cdb\u7d20\u8fde\u63a5\u9176\u7ed3\u5408\u57df\u548c\u4e00\u4e2aMALT1\u9776\u5411\u57df\uff0c\u4e24\u90e8\u5206\u901a\u8fc7\u94fe\u72b6\u7ed3\u6784\u76f8\u8fde\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728WB\u68c0\u6d4b\u4e2d\u80fd\u591f\u4fc3\u8fdb\u4eba\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624OCI-Ly3\u7ec6\u80de\u4e2d\u7684MALT1\u964d\u89e3\uff0831-50%@1 mcM\uff09\uff0c\u4e14\u5728cereblon\uff08CRBN\uff09\u91ce\u751f\u578b\u7ec6\u80de\u548cCRBN-\u6572\u9664\u7684293T\u7ec6\u80de\u4e2d\uff08@10 mcM\uff09\u4e5f\u6709\u76f8\u4f3c\u6548\u679c\u3002\uff08\u8be6\u89c1WO 2018085247\uff09\u3002<\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;\"><span style=\"font-size:14px;line-height:107%;color:#404040;\">&nbsp;<\/span><span style=\"font-size:16px;line-height:107%;color:#505050;\"> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532925026.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;\"><span style=\"font-size:16px;line-height:107%;color:#505050;\"> <\/span><br  \/><\/p>\n<p style=\"text-align: center;background: white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u56fe\u4e3aWO 2018085247\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u670812\u65e5\uff0c\u9ed8\u514b\u53d1\u8868tepotinib\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8aII\u671f\u6570\u636e<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u9ed8\u514b\u516c\u53f8\u53d1\u5e03\u4e86\u6297\u80bf\u7624\u5019\u9009\u836f\u7269tepotinib\u7684\u4e24\u9879\u4e50\u89c2\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u4e24\u9879\u8bd5\u9a8c\u5206\u522b\u9488\u5bf9Child-Pugh\u809d\u529f\u80fd\u4e3aA\u7ea7\u7684MET-\u9633\u6027\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\uff0c\u5747\u8fbe\u5230\u4e86\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002\u5728\u7b2c\u4e00\u7ec4\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u7684IB\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0ctepotinib\u5728\u4e9a\u6d32\u60a3\u8005\u4e2d\u4f5c\u4e3a\u4e00\u7ebf\u7528\u836f\u4e0e\u7d22\u62c9\u975e\u5c3c\u8fdb\u884c\u5bf9\u6bd4\uff08Clinicaltrialtrials.gov\u7f16\u53f7NCT01988493\uff09\uff0c\u5176\u4e3b\u8981\u7ec8\u70b9\u662f\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\u8bc4\u4f30\u7684\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\uff08\u57fa\u4e8eRECIST1.1\u7248\uff09\u3002\u7b2c\u4e8c\u9879\u591a\u4e2d\u5fc3\u7684\u5355\u81c2IB\/II\u671f\u8bd5\u9a8c\u7814\u7a76\u4e86tepotinib\u4f5c\u4e3a\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u60a3\u8005\u7684\u4e8c\u7ebf\u6cbb\u7597\u65b9\u6848\uff08Clinicaltrialtrials.gov\u7f16\u53f7NCT02115373\uff09\uff0c\u5176\u4e3b\u8981\u7ec8\u70b9\u662f\u7814\u7a76\u8005\u8bc4\u4f30\u768412\u5468\u65e0\u8fdb\u5c55\u751f\u5b58\u72b6\u6001\uff08\u57fa\u4e8eRECIST 1.1\u7248)\u3002\u5728\u8fd9\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u8be5\u836f\u7684\u5b89\u5168\u6027\u6570\u636e\u4e0eIB\u671f\u6570\u636e\u4e00\u81f4\uff0c\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u98ce\u9669\u3002\u6b64\u5916\uff0c\u9ed8\u514b\u516c\u53f8\u6b63\u5728\u5bf9tepotinib\u5f00\u5c55\u9488\u5bf9\u542b\u6709MET\u5916\u663e\u5b5014\u8df3\u8dc3\u7a81\u53d8\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u8fd1\u671f\u53d1\u8868\u7684\u4e2d\u671f\u6570\u636e\u8868\u660e\uff0c\u8be5\u836f\u5728\u6cbb\u7597\u7ec4\u663e\u793a\u4e86\u6297\u80bf\u7624\u4e34\u5e8a\u6d3b\u6027\u3002\u4eca\u5e743\u6708\uff0c\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\u6388\u4e88\u4e86tepotinib\u7684SAKIGAKE\u8d44\u683c\uff08\u5148\u9a71\u8d44\u683c\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u542b\u6709MET\u5916\u663e\u5b5014\u8df3\u8dc3\u7a81\u53d8\u7684NSCLC\u3002\uff08\u9ed8\u514b\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532925027.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.5em;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">\u56fe\u4e3aTepotinib\u7ed3\u6784<\/span><\/p>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<blockquote style=\"white-space: normal;\">\n<h2><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\"><\/span><\/strong><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u670820\u65e5\uff0cACY-1215\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">\u6765\u81ea\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u53d1\u8868\u4e86\u53e3\u670d\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC6\uff09\u6291\u5236\u5242ACY-1215\uff08rocilinostat\uff0cCelgene\u516c\u53f8\uff09\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684IB\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff08ClinicalTrials.gov\u7f16\u53f7NCT02632071\uff09\u3002\u5171\u670917\u540d\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u53c2\u4e0e\u4e86\u6b64\u6b21\u5f00\u653e\u6807\u7b7e\u7684\u7814\u7a76\u3002\u53d7\u8bd5\u8005\u572828\u5929\u4e3a\u5468\u671f\u7684\u7b2c1\u5929\u3001\u7b2c8\u5929\u548c\u7b2c15\u5929\u5206\u522b\u53e3\u670d\u6bcf\u65e5\u5242\u91cf\u4e3a80 \u2013 240 mg\u7684ACY-1215\uff08\u6db2\u4f53\uff09\uff0c\u5916\u52a0100\u6beb\u514b\/m2\u7684\u767d\u86cb\u767d\u7d2b\u6749\u9187\u300217\u4f8b\u60a3\u8005\u5171\u670915\u4f8b\u53c2\u4e0e\u4e86\u8bc4\u4f30\u3002\u96642\u4f8b\u63a5\u53d7240mg\u5242\u91cf\u7684\u53d7\u8bd5\u8005\u5916\uff0c\u5176\u4f59\u60a3\u8005\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u76f8\u5173\u6027\u6bd2\u6027\u3002\u96641\u4f8b3\/4\u7ea7\u7684\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u5916\uff0c\u6240\u6709\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u5747\u4e3a1-2\u7ea7\u3002\u6700\u5e38\u89c1\u7684\u662f\u8131\u53d1\u3001\u5934\u6655\u3001\u8d2b\u8840\u3001\u75b2\u52b3\u3001\u8179\u75db\u548c\u9f3b\u51fa\u8840\u3002\u8054\u5408\u6cbb\u7597\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e2d\u4f4d\u6570\u4e3a4.5\u4e2a\u6708\u3002\u4e34\u5e8a\u83b7\u76ca\u7387\u4e3a33%\uff0c2\u4f8b\u663e\u793a\u90e8\u5206\u5e94\u7b54\uff0c3\u4f8b\u75c5\u60c5\u7a33\u5b9a\u671f\u8fbe6\u4e2a\u6708\u4ee5\u4e0a\u3002\u8fd92\u4f8b\u90e8\u5206\u5e94\u7b54\u5747\u51fa\u73b0\u5728HR\u9633\u6027\/HER2\u9634\u6027\u7684\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u8be5\u836f\u5177\u6709\u9488\u5bf9\u6027\u6548\u679c\u3002ACY-1215\u7684\u7b2c\u4e8c\u9636\u6bb5\u63a8\u8350\u5242\u91cf\u88ab\u786e\u5b9a\u4e3a\u6bcf\u5929\u53e3\u670d240mg\u3002\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cHDAC6\u7684\u8bc4\u5206\u53ef\u80fd\u8bc6\u522b\u51fa\u5bf9\u6b64\u6291\u5236\u5242\u6709\u54cd\u5e94\u7684\u60a3\u8005\u3002\u80bf\u7624\u8bc4\u4f30\u6b63\u5728\u8fdb\u4e00\u6b65\u8fdb\u884c\u4ee5\u8bc1\u5b9e\u8fd9\u4e00\u53d1\u73b0\u3002\uff08Kalinsky,K. et al. 54th Annu Meet Am SocClinOncol (ASCO) (June 1-5, Chicago) 2018, Abst1058\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.5em;\"><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532925027.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\">\u56fe\u4e3aRocilinostat\u7ed3\u6784<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<blockquote style=\"white-space: normal;\">\n<h2><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\"><\/span><\/strong><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u670820\u65e5\uff0cCan-Fite\u516c\u53f8\u53d1\u5e03namodenoson\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684II\u671f\u4e34\u5e8a\u6570\u636e<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">Can-Fite\u516c\u53f8\u53d1\u5e03\u4e86namodenoson\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08Child-PughB\u7ea7\uff09\u7684II\u671f\u4e34\u5e8a\u6570\u636e\uff0c\u53d7\u8bd5\u8005\u4e3a\u4f7f\u7528\u7d22\u62c9\u83f2\u5c3c\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff08ClinicalTrials.gov\u7f16\u53f7NCT02128958\uff09\u3002\u8fd9\u9879\u7814\u7a76\u4e2d\u57fa\u4e8e\u5b58\u6d3b\u7387\u7684\u6700\u7ec8\u5206\u6790\u7531\u4e8e\u53d7\u8bd5\u8005\u5bff\u547d\u8d85\u8fc7\u6700\u521d\u7684\u9884\u671f\u800c\u88ab\u63a8\u8fdf\uff0cCan-Fite\u516c\u53f8\u9884\u8ba1\u5728\u5e74\u5e95\u524d\u7ed9\u51fa\u5206\u6790\u7ed3\u679c\u3002\u8fd9\u9879\u5168\u7403\u6027\u7814\u7a76\u6b63\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4ee5\u8272\u5217\u8fdb\u884c\uff0c\u53d7\u8bd5\u8005\u63a5\u53d7\u6bcf\u5929\u4e24\u6b2125 mg\u7684\u53e3\u670dnamodenoson\u6216\u5b89\u6170\u5242\u8fdb\u884c\u6cbb\u7597\uff0c\u968f\u673a\u5206\u7ec4\u6bd4\u4f8b\u4e3a2:1\u3002\u5176\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3001\u5b89\u5168\u6027\u4ee5\u53ca\u4e34\u5e8a\u7ed3\u679c\u4e0eA3AR\u57fa\u56e0\u8868\u8fbe\u4e4b\u95f4\u7684\u5173\u7cfb\u300278\u540d\u60a3\u8005\u7684\u62db\u52df\u5df2\u4e8e\u53bb\u5e748\u6708\u5b8c\u6210\u3002\u8be5\u7814\u7a76\u91c7\u7528\u53cc\u76f2\u6cd5\uff0cCan-Fite\u516c\u53f8\u6307\u51fa\uff0c\u5728\u6700\u521d\u53c2\u4e0e\u5b9e\u9a8c\u768478\u540d\u53d7\u8bd5\u8005\u4e2d\uff0c\u670919\u4eba\u5b8c\u6210\u4e86\u81f3\u5c1112\u4e2a\u7597\u7a0b\uff08\u6bcf\u4e2a\u7597\u7a0b\u4e3a28\u5929\uff09\uff0c\u5176\u4e2d3\u4eba\u5b8c\u6210\u4e86\u81f3\u5c1124\u4e2a\u7597\u7a0b\u3002\u65f6\u95f4\u6700\u957f\u7684\u53d7\u8bd5\u8005\u5df2\u63a5\u53d7\u6cbb\u7597\u5927\u7ea63\u5e74\u3002\u8fc4\u4eca\u79ef\u7d2f\u7684\u5b89\u5168\u6570\u636e\u663e\u793a\u4e86\u826f\u597d\u7684\u5b89\u5168\u8010\u53d7\u6027\uff0c\u65e0\u4efb\u4f55\u91cd\u5927\u4e34\u5e8a\u4e8b\u4ef6\u5f52\u56e0\u4e8e\u8be5\u836f\u7684\u6162\u6027\u6cbb\u7597\u3002Namodenson\u5728\u6b27\u6d32\u548c\u7f8e\u56fd\u90fd\u88ab\u6388\u4e88\u5b64\u513f\u836f\u5730\u4f4d\uff0c\u5728\u7f8e\u56fd\u8fd8\u4f5c\u4e3aHCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u624b\u6bb5\u800c\u83b7\u5f97\u4e86\u5feb\u901f\u901a\u9053\u8d44\u683c\u3002\uff08Can-FiteBioPharma\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.5em;\"><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532925027-1.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">\u56fe\u4e3aNamodenoson\u7ed3\u6784<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: windowtext;font-size: 14px;text-align: justify;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;font-size: 21px;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\"><\/span><\/strong><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u67085\u65e5\uff0c\u9ad8\u7ea7\u522b\u8180\u80f1\u764c\u5c0f\u9f20\u6a21\u578b\u53ef\u7528\u6765\u9a8c\u8bc1\u514d\u75ab\u7597\u6cd5\u7684\u6709\u6548\u6027<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u8180\u80f1\u764c\u662f\u4e16\u754c\u4e0a\u7b2c\u4e5d\u5927\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\uff0c\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u5730\u533a\u662f\u5357\u6b27\u3001\u897f\u6b27\u548c\u5317\u7f8e\u3002\u8180\u80f1\u764c\u65e2\u5305\u62ec\u4f4e\u7ea7\u522b\u7684\u975e\u4fb5\u88ad\u6027\u7684\u80bf\u7624\uff0c\u4e5f\u5305\u62ec\u53ef\u4fb5\u72af\u808c\u8089\u7ec4\u7ec7\u548c\u8f6c\u79fb\u6027\u7684\u9ad8\u7ea7\u522b\u80bf\u7624\u3002\u5728\u9ad8\u7ea7\u522b\u7684\u808c\u8089\u4fb5\u88ad\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u4e2d\uff0c\u53ef\u6839\u636e\u5176RNA\u8868\u8fbe\u8c31\u5206\u4e3a\u8154\u6837\u548c\u57fa\u5e95\u6837\u4e24\u79cd\u4e9a\u578b\u3002\u665a\u671f\u8180\u80f1\u764c\u7684\u6807\u51c6\u6cbb\u7597\u5747\u662f\u57fa\u4e8e\u987a\u94c2\uff0c\u4f46\u81ea2016\u5e74\u4ee5\u6765\uff0c\u4e00\u4e9b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u88ab\u9646\u7eed\u6279\u51c6\u7528\u4e8e\u8fd9\u7c7b\u8f6c\u79fb\u6027\u6216\u5c40\u90e8\u8fdb\u5c55\u6027\u80bf\u7624\u3002\u7136\u800c\uff0c\u5bf9\u8fd9\u4e9b\u514d\u75ab\u68c0\u67e5\u70b9\u6297\u4f53\u7684\u53cd\u5e94\u53d6\u51b3\u4e8e\u4e00\u4e9b\u5185\u5728\u7684\u80bf\u7624\u7279\u5f81\uff0c\u5982\u7a81\u53d8\u3001\u5206\u5b50\u4e9a\u578b\u4ee5\u53ca\u80bf\u7624\u5fae\u73af\u5883\u7b49\uff0c\u53ea\u670920-30%\u7684\u60a3\u8005\u6709\u6548\u3002\u6700\u8fd1\uff0c\u5317\u5361\u7f57\u83b1\u7eb3\u5927\u5b66\u83b1\u56e0\u4f2f\u683c\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u5efa\u7acb\u4e86\u4e0e\u4eba\u76f8\u5173\u7684\u8180\u80f1\u764c\u5c0f\u9f20\u6a21\u578b\uff0c\u6216\u6709\u52a9\u4e8e\u7406\u89e3\u514d\u75ab\u7597\u6cd5\u7684\u4e0d\u540c\u53cd\u5e94\u3002\u79d1\u5b66\u5bb6\u4eec\u8bbe\u8ba1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u9ad8\u7ea7\u522b\u8180\u80f1\u764c\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u53ef\u518d\u751f\u51fa\u8154\u6837\u5206\u5b50\u4e9a\u578b\u7684\u80bf\u7624\uff08\u5982Upk3a-CreERT2\uff1bTrp53L\/L\uff1bPtenL\/L\uff1bRosa26LSL-Luc\u6216UPPL\u7684\u5c0f\u9f20\uff09\u3002\u9664\u4e86\u9488\u5bf9\u8154\u6837UPPL\u80bf\u7624\u7684\u6a21\u578b\u5916\uff0c\u4ed6\u4eec\u8fd8\u5efa\u7acb\u4e86\u7531N-\u4e01\u57fa-N-(4-\u7f9f\u57fa\u4e01\u57fa)\u4e9a\u785d\u80fa\uff08BBN\uff09\u8bf1\u5bfc\u7684\u5c0f\u9f20\u57fa\u5e95\u6837\u80bf\u7624\u6a21\u578b\u3002\u8180\u80f1\u764cUPPL1541\u548c\u8180\u80f1\u764cBBN963\u5c0f\u9f20\u6a21\u578b\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u6bd4\u5e7f\u6cdb\u4f7f\u7528\u7684MB49\u7ec6\u80de\u80fd\u591f\u66f4\u51c6\u786e\u7684\u6a21\u62df\u4eba\u7c7b\u8180\u80f1\u764c\u3002\u5728\u5bf9\u514d\u75ab\u611f\u53d7\u6001\u5c0f\u9f20\u8fdb\u884c\u79fb\u690d\u540e\uff0cBBN\u80bf\u7624\u6bd4UPPL\u80bf\u7624\u5bf9\u5bf9\u514d\u75ab\u68c0\u6d4b\u70b9\u6291\u5236\u5242\u7684\u53cd\u5e94\u66f4\u5f3a\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u514d\u75ab\u5fae\u73af\u5883\u5dee\u5f02\u9020\u6210\uff0c\u5982CD8+\u4e0eCD4+\u3001\u8bb0\u5fc6\u6027\u4e0e\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u6bd4\u503c\u589e\u52a0\u7b49\u3002UPPL\u548cBBN\u6a21\u578b\u90fd\u8868\u8fbe\u4e86\u9776\u5411\u7684\u3001\u514d\u75ab\u539f\u6027\u7684\u65b0\u6297\u539f\uff0c\u56e0\u6b64\u53ef\u4f5c\u4e3a\u672a\u6765\u7814\u7a76\u8180\u80f1\u764c\u751f\u7269\u5b66\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u6216\u5176\u4ed6\u514d\u75ab\u6cbb\u7597\u7684\u6709\u7528\u5de5\u5177\u3002\uff08Saito,R. et al. Cancer Res 2018, Advanced publication\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">4<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;font-size: 14px;\"><strong>\u4ee3\u8c22\u7c7b\u75be\u75c5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><br  \/><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\"><\/span><\/strong><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;color: rgb(104, 23, 255);\"><strong>2018\u5e746\u67085\u65e5\uff0cGS-0976\u5bf9NASH\u809d\u786c\u5316\u60a3\u8005\u8868\u73b0\u51fa\u663e\u8457\u7597\u6548<\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u5409\u5229\u5fb7\u516c\u53f8\u7684\u809d\u9776\u5411\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff08ACC\uff09\u53d8\u6784\u6291\u5236\u5242GS-0976\uff08firsocostat\uff09\u6b63\u5728\u9488\u5bf9\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684\u4ee3\u507f\u6027\u809d\u786c\u5316\u7684\u60a3\u8005\u8fdb\u884c\u6982\u5ff5\u9a8c\u8bc1\u6027\u7814\u7a76\u3002\u521d\u6b65\u7ed3\u679c\u62a5\u9053\u5728\u534e\u76db\u987f\u7684\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\u5468\u62a5\u4e2d\u3002\u517110\u540d\u53d7\u8bd5\u8005\u4f7f\u7528\u4e86\u53e3\u670d\u65e5\u5242\u91cf20mg\u8be5\u836f\u8fdb\u884c\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u7684\u7b2c12\u5468\uff0c\u809d\u810f\u8102\u80aa\u65b0\u751f\u6570\u91cf\u6bd4\u57fa\u7ebf\u51cf\u5c11\u4e8632%\uff0c\u4e14\u78c1\u5171\u632f\u6210\u50cf\u6d4b\u91cf\u7684\u8d28\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6570\uff08MRI-PDFF\uff09\u663e\u8457\u4e0b\u964d\u4e8639%\uff0c\u6838\u78c1\u5171\u632f\u5f39\u6027\u6210\u50cf\u7684\u809d\u810f\u786c\u5ea6\u503c\u4e0d\u53d7\u6cbb\u7597\u5f71\u54cd\u3002\u540c\u65f6\uff0c\u8840\u6e05\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\u6c34\u5e73\u663e\u8457\u964d\u4f4e\u4e8628.8%\u3002GS-0976\u7684\u5b89\u5168\u6027\u826f\u597d\uff0c\u53d1\u751f\u4e00\u6b213\u7ea7\u6cbb\u7597\u7a81\u53d1\u4e8b\u4ef6\uff08\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff09\uff0c\u4e24\u6b212\u7ea7\u6216\u4ee5\u4e0a\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u548c\u75b2\u52b3\uff09\u548c\u56db\u6b213\u7ea7\u6cbb\u7597\u7a81\u53d1\u5b9e\u9a8c\u5ba4\u5f02\u5e38\u65f6\u95f4\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u9ad8\u8840\u7cd6\u75c7\u3001\u4f4e\u94a0\u8840\u75c7\u548c\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff09\u3002\u76ee\u524d\u6b63\u5728\u62db\u52df\u7684\u8fd8\u5305\u62ec\u4e00\u4e2a\u9488\u5bf9\u809d\u810f\u529f\u80fd\u6b63\u5e38\u6216\u8f7b\u5ea6\uff0c\u4e2d\u5ea6\u6216\u4e25\u91cd\u809d\u635f\u4f24\u7684I\u671f\u7814\u7a76\uff08ClinicalTrials.gov\u7f16\u53f7NCT02891408\uff09\u548c\u4e00\u4e2a\u7814\u7a76selonsertib\u3001GS-0976\u548cGS-9674\u5355\u72ec\u6216\u8054\u5408\u7528\u836f\u6cbb\u7597NASH\u5bfc\u81f4\u7684\u809d\u7ea4\u7ef4\u5316\u6216\u4ee3\u507f\u6027\u809d\u786c\u5316\u7684\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov\u7f16\u53f7NCT03449446\uff09\u3002\uff08Harrison, S.A. et al. Dig Dis Week (DDW) (June 2-5,Washignton, D.C.) 2018, Abst Su1521\uff09\u3002<\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532925027.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"text-align: center;background: white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u56fe\u4e3aFirsocostat\u7ed3\u6784<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: left;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<blockquote style=\"white-space: normal;\">\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;color: rgb(104, 23, 255);\"><strong>2018\u5e746\u67087\u65e5\uff0cS1P\u5bf9\u9aa8\u8d28\u91cf\u7684\u8c03\u8282\u8d77\u5230\u5173\u952e\u4f5c\u7528\uff0c\u6216\u6210\u4e3a\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u7684\u9776\u6807<\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u9798\u80fa\u9187-1-\u78f7\u9178\uff08S1P\uff09\u5728\u53d1\u80b2\u3001\u514d\u75ab\u548c\u9aa8\u4ee3\u8c22\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002S1P\u53ef\u901a\u8fc7\u9aa8\u548c\u8840\u6d46\u4e4b\u95f4\u7684\u68af\u5ea6\u53c2\u4e0e\u8c03\u8282\u6210\u9aa8\u7ec6\u80de\u5faa\u73af\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u9aa8\u9abc\u91cd\u6784\u3002S1P\u7684\u6c34\u5e73\u88ab\u51e0\u4e2a\u78f7\u9178\u9176\u7684\u8131\u78f7\u9178\u5316\u4f5c\u7528\u548cS1P\u88c2\u89e3\u91761\u7684\u4e0d\u53ef\u9006\u964d\u89e3\u4e25\u683c\u63a7\u5236\u3002\u5c3d\u7ba1\u57fa\u4e8eS1P\u7684\u836f\u7269\u53ef\u7528\u4e8e\u6cbb\u7597\u9aa8\u9abc\u75be\u75c5\uff0c\u4f46\u4eba\u4eec\u5bf9\u6b63\u5e38\u6216\u75be\u75c5\u6761\u4ef6\u4e0bS1P\u8c03\u8282\u9aa8\u7a33\u6001\u7684\u673a\u5236\u548c\u4f53\u5185S1P\u6c34\u5e73\u6539\u53d8\u6240\u5e26\u6765\u7684\u5f71\u54cd\u77e5\u4e4b\u751a\u5c11\u3002\u57c3\u68ee\u5927\u5b66\u533b\u5b66\u9662\u75c5\u7406\u751f\u7406\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u8fd1\u65e5\u8bc4\u4f30\u4e86S1P\u6c34\u5e73\u548c\u68af\u5ea6\u5bf9\u5c0f\u9f20\u9aa8\u5185\u7a33\u6001\u7684\u5f71\u54cd\u3002S1P\u88c2\u89e3\u9176\u7684\u9057\u4f20\u7f3a\u5931\u6216S1P\u7c7b\u4f3c\u7269FTY-720\uff08fingolimod\uff09\u7684\u6291\u5236\u53ef\u4ee5\u5bfc\u81f4S1P\u6c34\u5e73\u5347\u9ad8\uff0c\u5e76\u901a\u8fc7\u51e0\u4e2a\u975e\u5197\u4f59\u7684\u673a\u5236\u8fdb\u4e00\u6b65\u5bfc\u81f4\u9aa8\u9abc\u7684\u5f62\u6210\u3001\u9aa8\u8d28\u91cf\u548c\u5f3a\u5ea6\u7684\u663e\u8457\u589e\u52a0\u548c\u767d\u8272\u8102\u80aa\u7ec4\u7ec7\u7684\u660e\u663e\u51cf\u5c11\u3002\u5728\u5c0f\u9f20\u7684\u9057\u4f20\u548c\u6fc0\u7d20\u6027\u9aa8\u8d28\u758f\u677e\u6a21\u578b\u4e2d\uff0cS1P\u9176\u6291\u5236\u63d0\u4f9b\u4e86\u663e\u8457\u7684\u6cbb\u7597\u83b7\u76ca\u3002\u5728\u5fb7\u56fd\u8fdb\u884c\u7684\u4e00\u9879\u57fa\u4e8e4000\u4eba\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86S1P\u6c34\u5e73\u4e0e\u9aa8\u9abc\u53c2\u6570\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u6570\u636e\u663e\u793a\uff0c\u8840\u6e05S1P\u6c34\u5e73\u4e0e\u591a\u79cd\u9aa8\u5f62\u6210\u6807\u5fd7\u7269\u5448\u6b63\u76f8\u5173\u6027\uff0c\u4f46\u4e0e\u5438\u6536\u6807\u5fd7\u7269\u548c\u8840\u6e05\u9499\u65e0\u5173\u3002S1P\u4e0e\u7532\u72b6\u65c1\u817a\u6fc0\u7d20\u5448\u8d1f\u76f8\u5173\uff0c\u4e0e\u4f53\u91cd\u6307\u6570\u5448\u66f2\u7ebf\u76f8\u5173\u3002\u6b64\u5916\uff0cS1P\u6c34\u5e73\u4e0e\u9aa8\u786c\u5ea6\u5448\u53cd\u6bd4\u5173\u7cfb\uff0c\u6697\u793aS1P\u53ef\u523a\u6fc0\u9aa8\u5408\u6210\u4ee3\u8c22\u6d3b\u52a8\u4ee5\u62b5\u6d88\u9aa8\u8d28\u91cf\u4e0b\u964d\u7684\u5f71\u54cd\u3002\u4e0a\u8ff0\u7ed3\u679c\u63ed\u793a\u4e86S1P\u4e0e\u9aa8\u8d28\u91cf\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u5e76\u6307\u51fa\u57fa\u4e8eS1P\u7684\u836f\u7269\u6216\u53ef\u7528\u4e8e\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u75c7\u3002\uff08Weske, S. et al. Nat Med 2018, 24(5): 667\uff09\u3002<\/span><\/p>\n<p><span style=\"letter-spacing: 0.5px;font-size: 14px;line-height: 16.8px;color: windowtext;\"><br  \/><\/span><br  \/><\/p>\n<blockquote style=\"white-space: normal;\">\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><span style=\"font-size: 14px;\"><strong>2018\u5e74<\/strong><\/span><strong style=\"font-size: 14px;\">6\u670827\u65e5\uff0c\u4e2d\u5916\u5236\u836f\u62a5\u9053\u53e3\u670d\u6709\u6548\u7684\u975e\u80bd\u7c7bGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242OWL-833<\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;background-color: white;text-align: justify;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;background-color: white;text-align: justify;\">\u5728\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\u7b2c78\u5c4a\u79d1\u5b66\u4f1a\u8bae\u4e0a\uff0c\u4e2d\u5916\u5236\u836f\u62a5\u9053\u4e86\u5176\u53e3\u670d\u975e\u80bd\u7c7bGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242OWL-833\u7684\u53d1\u73b0\u3001\u7597\u6548\u3001\u5b89\u5168\u6027\u4ee5\u53ca\u7315\u7334\u4f53\u5185\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u3002\u5728\u4f53\u5916\u7814\u7a76\u4e2d\uff0c\u8be5\u5316\u5408\u7269\u88ab\u8bc1\u5b9e\u662f\u4e00\u79cd\u6709\u6548\u7684\u9009\u62e9\u6027GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u3002\u5728\u4ebaGLP-1\u53d7\u4f53\u8f6c\u67d3\u7ec6\u80de\u4e0e\u7315\u7334GLP-1\u53d7\u4f53\u8f6c\u67d3\u7ec6\u80de\u4e2d\uff0c\u5176cAMP\u7d2f\u79ef\u4f5c\u7528\u7684EC50\u503c\u5747\u4e3a1.1 nM\u3002\u5728\u5c0f\u9f20\u3001\u5927\u9f20\u3001\u72d7\u6216\u5154\u7684GLP-1\u53d7\u4f53\u8f6c\u67d3\u7ec6\u80de\u4e2d\uff0c\u8be5\u5316\u5408\u7269\u6ca1\u6709\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u5728\u4ebaGCGR\u3001\u4ebaGIPR\u6216\u4ebaGLP-2\u53d7\u4f53\u8f6c\u67d3\u7684\u7ec6\u80de\u4e2d\uff0cOWL-833\u6ca1\u6709\u8868\u73b0\u51fa\u6d3b\u6027\u3002OWL-833\u5bf9\u5927\u9f20\uff080.15 mg\/kg\uff09\u6216\u7315\u7334\uff080.12 mg\/kg\uff09\u9759\u8109\u6ce8\u5c04\u7684\u534a\u8870\u671f\u5206\u522b\u4e3a13.9\u5c0f\u65f6\u548c3.9\u5c0f\u65f6\u3002\u5927\u9f20\u53e3\u670d\u7ed9\u836f\uff080.05-0.45 mg\/kg\uff09\u7684\u534a\u8870\u671f\u4e3a10.4-12.4\u5c0f\u65f6\uff0c\u751f\u7269\u5229\u7528\u5ea6\u4e3a33-43%\u3002\u7315\u7334\u53e3\u670d\u7ed9\u836f\u7684\u4e0a\u8ff0\u6570\u636e\u4e3a3.4-4.6\u5c0f\u65f6\u548c21-28%\u3002\u5728\u4e00\u9879\u4ea4\u53c9\u7814\u7a76\u4e2d\uff0c\u5728\u9ebb\u9189\u96c4\u6027\u7315\u7334\uff08n=7\uff09\u4e2d\uff0c\u521d\u59cb\u7ed9\u836f\u540e\u6301\u7eed\u7ed9\u4e88OWL-833\u81f3\u836f\u7269\u6d53\u5ea6\u8fbe\u7a33\u5b9a\u72b6\u6001\u540e\uff0c\u5728\u4f53\u5185\u8868\u73b0\u51fa\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u80f0\u5c9b\u7d20\u5206\u6ccc\u7684\u6539\u5584\u3002\u5728\u4e24\u5468\u7684\u6bd2\u7406\u5b66\u7814\u7a76\u4e2d\uff0c\u5bf9\u5927\u9f20\u548c\u7315\u7334\u6ca1\u6709\u53d1\u73b0\u4e25\u91cd\u5b89\u5168\u98ce\u9669\u3002\u5728\u5bf9\u96c4\u7334\u8fdb\u884c\u7684\u4e9a\u6162\u6027\u4ea4\u53c9\u7814\u7a76\u4e2d\uff08n=8\uff09\uff0c\u53e3\u670dOWL-833\uff080.05\u548c0.1mg\/kg\uff09\u548c\u76ae\u4e0b\u6ce8\u5c04exenatide\uff080.3\u548c0.6 mcg\/kg\uff09\u80fd\u591f\u663e\u8457\u964d\u4f4e\u98df\u7269\u6444\u5165\u91cf\u3002\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0cOWL-833\u5177\u6709\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7597\u4ee3\u8c22\u7c7b\u75be\u75c5\u7684\u6f5c\u529b\u3002\uff08Kawai, T. et al. 78th Annu Meet SciSess AmDiabetes Assoc (ADA) (June 22-26, Orlando) 2018, Abst 1118-P\uff09\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;font-size: 21px;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u6297\u611f\u67d3\u836f\u7269<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote style=\"white-space: normal;\">\n<h2><strong><span style=\"font-size: 14px;color: rgb(122, 79, 214);\"><\/span><\/strong><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e74<\/span><\/strong><strong><span style=\"font-size: 14px;\">6\u670812\u65e5\uff0c\u9776\u5411HIV-1\u878d\u5408\u80bd\u7684\u4e2d\u548c\u6297\u4f53\u6709\u671b\u4f5c\u4e3a\u75ab\u82d7\u7814\u53d1\u7684\u65b0\u7b56\u7565<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\">HIV-1\u75ab\u82d7\u5f00\u53d1\u9700\u8981\u514b\u670d\u7684\u4e3b\u8981\u6311\u6218\u4e4b\u4e00\u662f\u8bf1\u5bfc\u51fa\u80fd\u591f\u4e2d\u548c\u4e0d\u540c\u75c5\u6bd2\u682a\u7684\u6297\u4f53\u3002\u76ee\u524d\u7684\u5019\u9009\u75ab\u82d7\u53ea\u80fd\u4e2d\u548c\u5c11\u90e8\u5206\u7684\u4e3b\u8981\u5206\u79bb\u682a\uff08\u5178\u578b\u7684HIV-1\u4f20\u64ad\u682a\uff09\u3002\u6765\u81ea\u7f8e\u56fdNIH\u75ab\u82d7\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u9776\u5411HIV-1\u878d\u5408\u80bd\uff08FP\uff09N\u7aef\u4fdd\u5b88\u533a\u57df\u6297\u4f53\uff08N123-VRC34.01\uff09\uff0c\u8fd9\u662f\u75c5\u6bd2\u8fdb\u5165\u673a\u5236\u7684\u4e00\u4e2a\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u6b64\u524d\u88ab\u8ba4\u4e3a\u514d\u75ab\u539f\u6027\u5f88\u5dee\u3002\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63cf\u8ff0\u4e86\u4e00\u4e2a\u4eceVRC34.01\u6297\u539f\u8868\u4f4d\u5f00\u59cb\u7684\u6297\u4f53-\u75ab\u82d7\u5f00\u53d1\u8fc7\u7a0b\uff0c\u8bbe\u8ba1\u51fa\u4e86\u5177\u6709\u878d\u5408\u80bd-\u8840\u84dd\u7d20\u86cb\u767d\u8f7d\u4f53\u5076\u8054\uff08FP8-KLH\uff09\u6297\u539f\u7279\u5f02\u6027\u7684\u514d\u75ab\u539f\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u5c06FP8-KLH\u5355\u72ec\u6216\u4e0eHIV-1\u7684Env\u86cb\u767d\u4e09\u805a\u4f53\uff08BG505.SOSIPEnv Trimer\uff09\u8054\u5408\u4f7f\u7528\uff0c\u8bf1\u5bfc\u51fa\u7684\u5355\u514b\u9686\u6297\u4f53\u80fd\u591f\u4e2d\u548c208\u682aHIV-1\u6bd2\u682a\u768431%\uff08\u4f5c\u4e3a\u5bf9\u7167\uff0c\u7b2c\u4e00\u4ee3\u878d\u5408\u80bd\u6297\u4f53\u6700\u591a\u4e2d\u548c10%\u7684HIV-1\u6bd2\u682a\uff09\u3002\u6297\u4f53\u7684\u6676\u4f53\u548c\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u7ed3\u6784\u63ed\u793a\u4e86\u878d\u5408\u80bd\u5177\u6709\u6784\u8c61\u591a\u6837\u6027\uff0c\u8fd9\u53ef\u80fd\u662f\u5176\u4ea4\u53c9\u4e2d\u548c\u4f5c\u7528\u7684\u5206\u5b50\u673a\u5236\u3002\u5728\u8c5a\u9f20\u548c\u6052\u6cb3\u7334\u4f53\u5185\u4e5f\u53ef\u8bf1\u5bfc\u51fa\u76f8\u4f3c\u7684FP\u7279\u5f02\u6027\u7684\u5e7f\u6cdb\u4e2d\u548c\u53cd\u5e94\u3002\u5c3d\u7ba1\u4e00\u4e9b\u7279\u5f81\u5982\u5e7f\u5ea6\u3001\u6548\u529b\u548c\u4e00\u81f4\u6027\u9700\u8981\u6539\u8fdb\uff0c\u4f46\u8be5\u75ab\u82d7\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u79cd\u6982\u5ff5\u6027\u7684\u9a8c\u8bc1\uff0c\u8868\u660e\u4e86HIV-1\u878d\u5408\u80bd\u7684N\u7aef\u662f\u8bf1\u53d1\u5e7f\u6cdb\u4e2d\u548c\u6297\u4f53\u75ab\u82d7\u7684\u6f5c\u5728\u4f4d\u70b9\uff0c\u4e14\u53ef\u5bf9\u6297\u5927\u591a\u6570HIV-1\u75c5\u6bd2\u682a\uff0c\u662f\u5f00\u53d1\u5e7f\u6cdb\u4e2d\u548c\u75ab\u82d7\u7684\u6f5c\u5728\u9776\u6807\u3002\uff08Xu, K. et al. Nat Med 2018, Advancedpublication\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"margin: 2.25pt 0in 3.75pt;white-space: normal;text-align: center;line-height: 11.25pt;background: white;\"><span style=\"font-size: 10.5pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><br  \/><\/span><\/p>\n<p style=\"margin: 2.25pt 0in 3.75pt;white-space: normal;text-align: center;line-height: 11.25pt;background: white;\"><span style=\"font-size: 10.5pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">6<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;font-size: 21px;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">\u5fc3\u8840\u7ba1\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><br  \/><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;color: rgb(104, 23, 255);\"><strong>2018\u5e746\u670820\u65e5\uff0cIdorsia\u516c\u53f8\u5f00\u5c55aprocitentan\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u9ad8\u8840\u538b\u7684\u4e34\u5e8aIII\u671f\u8bd5\u9a8c<\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\">Idorsia\u516c\u53f8\u540d\u4e3aPRECISION\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u62db\u52df\u4e86\u9996\u4f8b\u53d7\u8bd5\u8005\u3002\u8fd9\u662f\u4e00\u9879\u9488\u5bf9aprocitentan\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u96be\u6cbb\u6027\u9ad8\u8840\u538b\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7814\u7a76\uff08ClinicalTrials.gov\u7f16\u53f7NCT03541174\uff09\u3002\u6b64\u9879\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684\u591a\u4e2d\u5fc3\u968f\u673a\u53cc\u76f2\u7814\u7a76\u7684\u76ee\u7684\u662f\u9a8c\u8bc1\u5728\u9ad8\u8840\u538b\u60a3\u8005\u7684\u6807\u51c6\u7597\u6cd5\u4e2d\u52a0\u5165aprocitentan\u540e\u7684\u964d\u538b\u4f5c\u7528\uff0c\u5e76\u5c06\u4ee5\u5b89\u6170\u5242\u5bf9\u7167\u7684\u65b9\u5f0f\u63a2\u8ba8aprocitentan\u7684\u77ed\u671f\u7597\u6548\u53ca\u5176\u957f\u671f\u7597\u6548\u7684\u6301\u4e45\u6027\u3002\u5728\u7b5b\u9009\u8fc7\u7a0b\u4e2d\uff0c\u53d7\u8bd5\u8005\u7684\u80cc\u666f\u7597\u6cd5\u88ab\u8f6c\u5316\u4e3a\u9499\u901a\u9053\u963b\u6ede\u5242\uff08\u6c28\u6c2f\u5730\u5e73\uff09\u3001\u8840\u7ba1\u7d27\u5f20\u7d20\u53d7\u4f53\u963b\u6ede\u5242\uff08\u7f2c\u6c99\u5766\uff09\u548c\u5229\u5c3f\u5242\uff08\u6c22\u6c2f\u567b\u55ea\uff09\u7684\u6807\u51c6\u5316\u56fa\u5b9a\u7ec4\u5408\u3002\u96be\u6cbb\u6027\u9ad8\u8840\u538b\u60a3\u8005\u5c06\u88ab\u968f\u673a\u5206\u7ec4\uff0c\u6bcf\u5929\u63a5\u53d7\u4e00\u6b21aprocitentan12.5\u6beb\u514b\u300125\u6beb\u514b\u6216\u5b89\u6170\u5242\u3002\u8be5\u7814\u7a76\u5305\u62ec\u4e09\u4e2a\u8fde\u7eed\u6cbb\u7597\u671f\u3002\u7b2c\u4e00\u4e2a\u9636\u6bb5\u662f\u53cc\u76f2\u6cbb\u7597\u671f\uff0c\u76ee\u7684\u662f\u9a8c\u8bc1aprocitentan\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5728\u7b2c\u56db\u5468\u5bf9\u8840\u538b\u7684\u5f71\u54cd\u3002\u7136\u540e\u8fdb\u5165\u6cbb\u7597\u671f\uff0c\u4f7f\u752825\u6beb\u514b\u7684aprocitentan\u6cbb\u759732\u5468\u3002\u63a5\u4e0b\u6765\u7684\u53cc\u76f2\u968f\u673a\u6cbb\u7597\u671f\uff0c\u60a3\u8005\u6216\u7ee7\u7eed\u670d\u752825\u6beb\u514baprocitentan\uff0c\u6216\u572812\u5468\u5185\u6539\u7528\u5b89\u6170\u5242\uff0c\u76ee\u7684\u662f\u4e3a\u4e86\u8bc1\u660eaprocitentan\u7684\u6301\u4e45\u6027\uff0c\u968f\u540e\u8fdb\u516530\u5929\u7684\u5b89\u5168\u968f\u8bbf\u671f\u3002\u4ece\u6700\u521d\u7b5b\u67e5\u5f00\u59cb\uff0c\u5c06\u81f3\u5c11600\u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u5165\u7ec4\uff0c\u9884\u8ba1300\u540d\u60a3\u8005\u53ef\u5b8c\u6210\u6574\u9879\u7814\u7a76\u3002\u8be5\u7814\u7a76\u5c06\u5728\u7ea620\u4e2a\u56fd\u5bb6\u7684100\u4f59\u4e2a\u5730\u70b9\u8fdb\u884c\u3002Aprocitentan\u662f\u4e00\u79cd\u53e3\u670d\u7684\u53cc\u91cd\u5185\u76ae\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u5728\u9ad8\u8840\u538b\u52a8\u7269\u6a21\u578b\u6709\u6548\uff0c\u5e76\u80fd\u5728\u73b0\u6709\u7684\u6cbb\u7597\u65b9\u6cd5\u4e0a\u63d0\u4f9b\u663e\u8457\u7684\u964d\u538b\u4f5c\u7528\u3002\u5728\u4e00\u9879\u5bf9490\u4f8b\u539f\u53d1\u6027\u9ad8\u8840\u538b\u60a3\u8005\u7684\u5242\u91cf\u7814\u7a76\u4e2d\uff0c\u8be5\u836f\u80fd\u591f\u5242\u91cf\u4f9d\u8d56\u7684\u663e\u8457\u964d\u4f4e\u8840\u538b\u3002\u53bb\u5e7412\u6708\uff0cIdorsia\u516c\u53f8\u4e0eJanssen\u516c\u53f8\u7b7e\u7f72\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316aprocitentan\u53ca\u5176\u4efb\u4f55\u884d\u751f\u5316\u5408\u7269\u548c\u4ea7\u54c1\u3002\uff08Idorsia\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532925027-1.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10.5pt;background-color: white;\">\u56fe\u4e3a<\/span><span style=\"font-size: 14px;background-color: white;line-height: 107%;color: rgb(64, 64, 64);\">Aprocitentan<\/span><span lang=\"ZH-CN\" style=\"font-size: 10.5pt;background-color: white;\">\u7ed3\u6784<\/span><\/p>\n<p style=\"margin: 2.25pt 0in 3.75pt;white-space: normal;text-align: center;line-height: 11.25pt;background: white;\"><span style=\"font-size: 10.5pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><br  \/><\/span><\/p>\n<p style=\"margin: 2.25pt 0in 3.75pt;white-space: normal;text-align: center;line-height: 11.25pt;background: white;\"><span style=\"font-size: 10.5pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><br  \/><\/span><\/p>\n<p style=\"margin: 2.25pt 0in 3.75pt;white-space: normal;text-align: center;line-height: 11.25pt;background: white;\"><span style=\"font-size: 10.5pt;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><br  \/><\/span><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 14px;\">7<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;font-size: 14px;\"><strong>\u8840\u6db2\u4e0e\u51dd\u8840\u7cfb\u7edf\u75be\u75c5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;color: rgb(104, 23, 255);\"><strong>2018\u5e74<\/strong><strong>6\u67081\u65e5\uff0cAstellas\u4e0eFibroGen\u8054\u5408\u53d1\u5e03roxadustat\u65e5\u672c\u4e34\u5e8aIII\u671f\u7814\u7a76\u7684\u5173\u952e\u6027\u6570\u636e<\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\">Astellas Pharma\u516c\u53f8\u548cFibroGen\u516c\u53f8\u8fd1\u65e5\u62a5\u9053\u79f0roxadustat\u65e5\u672c\u4e34\u5e8aIII\u671f\u7814\u7a76\u8fbe\u5230\u5176\u9996\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002\u8fd9\u4e00\u9636\u6bb5\u7684\u8bd5\u9a8c\u8bc4\u4f30\u4e86roxadustat\u4e0edarbepoetin alfa\uff08\u57fa\u56e0\u91cd\u7ec4\uff09\u76f8\u6bd4\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u53d7\u8bd5\u8005\u4e3a\u60a3\u6709\u8d2b\u8840\u548c\u8840\u6db2\u900f\u6790\u4f9d\u8d56\u7684\u6162\u6027\u80be\u75c5\uff08CKD\uff09\u7684\u60a3\u8005\uff0c\u4ed6\u4eec\u4ee5\u524d\u66fe\u4f7f\u7528\u91cd\u7ec4\u4eba\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08rHuEPO\uff09\u6216darbepoetinalfa\u6cbb\u7597\u3002\uff08ClinicalTrials.gov\u7f16\u53f7NCT02278341\uff09\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u7ecf\u5386\u8fc7\u6cbb\u7597\u7684\u8840\u6db2\u900f\u6790\u60a3\u8005\u4e2d\uff0c\u5e73\u5747\u8840\u7ea2\u86cb\u767d\uff08Hb\uff09\u6c34\u5e73\u572818\u81f324\u5468\u80fd\u6709\u6548\u7ef4\u6301\u572810.99 g\/dL\u3002Roxadustat\u7ec4\u548cdarbepoetin\u7ec4\u7684\u4e3b\u8981\u7ec8\u70b9\u5206\u522b\u4e3aHb\u5e73\u5747\u6c34\u5e73\u4ece\u57fa\u7ebf\u5230\u7b2c18-24\u5468\u7684\u53d8\u5316\u4e3a-0.04 g\/dL\u548c-0.03 g\/dL\u3002\u6570\u636e\u8bc1\u5b9e\uff0croxadustat\u4e0edarbepoetin\u5728Hb\u53d8\u5316\u4e0a\u7684\u6cbb\u7597\u5dee\u5f02\u975e\u52a3\u6027\u768495%\u7f6e\u4fe1\u533a\u95f4\u4e3a\uff08-0.18\uff0c0.15\uff09\uff0c\u9ad8\u4e8e\u9884\u8bbe\u7684\u975e\u52a3\u6548\u6027\u8fb9\u754c\uff08-0.75g\/dL\uff09\u3002\u6b64\u5916\uff0croxadustat\u5728\u672c\u7814\u7a76\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u5176\u5b89\u5168\u6027\u4e0e\u6b64\u524d\u7814\u7a76\u4e2d\u900f\u6790\u548c\u975e\u900f\u6790\u60a3\u8005\u7684\u6570\u636e\u76f8\u7b26\u3002\uff08AstellasPharma\u65b0\u95fb\u7a3f\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.5em;text-align: center;\"><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532925027.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: windowtext;font-size: 14px;background-color: white;\">\u56fe\u4e3a<\/span><span style=\"font-size: 14px;background-color: white;line-height: 107%;color: rgb(64, 64, 64);\">Roxadustat<\/span><span style=\"color: windowtext;font-size: 14px;background-color: white;\">\u7ed3\u6784<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;font-size: 14px;\"><strong>8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;font-size: 14px;\"><strong>\u6297\u708e\u75c7\u836f\u7269<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: rgb(122, 79, 214);\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u670825\u65e5\uff0cAZD-9567\u7684\u4f53\u5185\u53ca\u4e34\u5e8a\u7597\u6548\u5747\u4f18\u4e8eprednisolone<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.5em;\"><span style=\"letter-spacing: 0.5px;font-size: 14px;line-height: 16.8px;color: windowtext;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.5em;\"><span style=\"letter-spacing: 0.5px;font-size: 14px;line-height: 16.8px;color: windowtext;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\">\u963f\u65af\u5229\u5eb7\u7684\u65b0\u578b\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u8c03\u8282\u5242AZD-9567\u7684\u4e34\u5e8a\u524d\u548c\u9996\u6b21\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\u4e86\u5176\u5728\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u65b9\u9762\u5177\u5907\u7684\u6f5c\u5728\u4f18\u52bf\u3002\u8be5\u836f\u7684\u4f53\u5916\u6297\u708e\u6d3b\u6027\uff08IC50= 6.2 nM\uff09\u9ad8\u51fa\u9633\u6027\u836f\u6cfc\u5c3c\u677e\u9f99\uff08prednisolone\uff097\u500d\u3002\u57fa\u4e8e\u4eba\u6210\u9aa8\u7ec6\u80de\u4e2d\u9aa8\u86cb\u767dmRNA\u7684\u8868\u8fbe\uff0cAZD-9567\u7684\u4f53\u5916\u6cbb\u7597\u6bd4\u7387\uff08TR\uff09\u4e3a8.8\uff0c\u6bd4\u6cfc\u5c3c\u9f99\u9ad89\u500d\u3002\u5728\u4f53\u5185\u7814\u7a76\u4e2d\uff0cAZD-9567\u5bf9\u5927\u9f20\u6539\u5584\u9aa8\u9499\u7d20\u7684TR\u4e3a5.6\u3002\u5728\u5927\u9f20\u8f85\u52a9\u5173\u8282\u708e\u6a21\u578b\u4e2d\uff0c\u4ee514\u5929\u964d\u4f4e\u5173\u8282\u708e\u8bc4\u5206\u7684AUC\u4f5c\u4e3a\u8861\u91cf\u5173\u8282\u708e\u7684\u6291\u5236\u6548\u679c\uff0c\u5176ED50\u4e3a0.1 mg\/kg\/\u5929\u3002\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cAZD-9567\u7684\u7597\u6548\u5728\u5242\u91cf\u722c\u5761\u7814\u7a76\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86AZD-9567\u5bf9TNF-alpha\u7684\u6291\u5236\u53ca\u5176\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff08Clinicaltrialtrials.gov\u7f16\u53f7NCT02512575\uff09\u3002\u7ed3\u679c\u8868\u660e\uff0cAZD-9567\u57282-155 mg\u8303\u56f4\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u663e\u793a\uff0c\u8be5\u836f\u57280.50\u52301.25\u5c0f\u65f6\u88ab\u5feb\u901f\u5438\u6536\uff08Tmax\uff09\uff0c\u66b4\u9732\u4eae\u663e\u793a\u51fa\u5242\u91cf\u4f9d\u8d56\u7279\u6027\u3002AZD-9567\u7684\u5e73\u5747\u7ec8\u672b\u534a\u8870\u671f\u4e3a3.9-6.4\u5c0f\u65f6\uff0c\u9002\u5408\u6bcf\u65e5\u4e00\u6b21\u7684\u5242\u91cf\u3002\u6b64\u5916\uff0c\u8be5\u836f\u53ef\u6d53\u5ea6\u4f9d\u8d56\u6027\u7684\u6291\u5236TNF-alpha\u7684\u91ca\u653e\uff0cIC50\u4e3a3.0 nM\uff0c\u4e0e\u4e34\u5e8a\u524d\u7ed3\u679c\u4e00\u81f4\u3002AZD-9567\u76ee\u524d\u6b63\u5728\u62db\u52df\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\uff0c\u4ee5\u8fdb\u884c\u4e0e\u6cfc\u5c3c\u677e\u9f99\u6bd4\u8f83\u7684\u4e34\u5e8aII\u671f\u7814\u7a76\u3002\uff08ClinicalTrials.gov\u7f16\u53f7NCT03368235\uff09\uff08Hendrickx, R. et al.AnnuEurCongrRheumatol (EULAR) (June 13-16, Amsterdam) 2018, Abst SAT0245\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532925027.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">\u56fe\u4e3aAZD-9567<span style=\"line-height: 14.98px;color: windowtext;\">\u7684<\/span>\u7ed3\u6784<\/span><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\"><br  \/><\/span><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section class=\"\" style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 2.6em;height: 2.6em;display: inline-block;vertical-align: middle;line-height: 2.6em;border-radius: 50%;background-color: rgb(142, 201, 101);box-sizing: border-box;\">\n<section style=\"margin-top: 0.36em;margin-bottom: 0.35em;margin-left: 0.44em;width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 50%;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"\" style=\"width: 28.7969px;height: 28.7969px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;font-size: 14px;\"><strong>9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: -0.5em auto 0.3em;width: 0px;border-top: 1.1em solid rgb(142, 201, 101);box-sizing: border-box;border-left: 1em solid transparent !important;border-right: 1.12em solid transparent !important;\"><\/section>\n<section class=\"\" style=\"padding-top: 1px;padding-right: 5px;padding-left: 5px;display: inline-block;border-top: 2px solid rgb(142, 201, 101);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;font-size: 14px;\"><strong>\u7cbe\u795e\u7c7b\u75be\u75c5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2 style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/h2>\n<blockquote style=\"white-space: normal;\">\n<h2><span style=\"color: rgb(122, 79, 214);\"><strong><span style=\"font-size: 14px;\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: rgb(122, 79, 214);\"><\/span><\/strong><\/span><\/h2>\n<h2 style=\"text-align: justify;line-height: 19.2px;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 14px;\">2018\u5e746\u67081\u65e5\uff0c\u9ed8\u514b\u516c\u53f8\u53d1\u73b0alpha7\u53d7\u4f53\u7684\u6b63\u5411\u53d8\u6784\u8c03\u8282\u5242<\/span><\/strong><\/span><\/h2>\n<\/blockquote>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.5em;\"><span style=\"letter-spacing: 0.5px;font-size: 14px;line-height: 16.8px;color: windowtext;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.5em;\"><span style=\"letter-spacing: 0.5px;font-size: 14px;line-height: 16.8px;color: windowtext;\"><\/span><\/p>\n<p style=\"text-align:justify;text-justify:inter-ideograph;background:white;\"><span style=\"color: rgb(0, 0, 0);font-size: 14px;\">\u9ed8\u514b\u516c\u53f8\u53d1\u73b0\u4e86\u4e00\u7c7b\u70df\u78b1alpha7\u53d7\u4f53\u7684\u6b63\u5411\u53d8\u6784\u8c03\u8282\u5242\uff08PAMs\uff09\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u548c\u5e15\u91d1\u68ee\u75c7\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728\u81ea\u52a8\u819c\u7247\u94b3\u6d4b\u8bd5\u4e2d\uff0c\u5bf9\u4eba\u80da\u80be\u7ec6\u80de\uff08HEK\uff09\u7684\u70df\u78b1alpha7\u53d7\u4f53\u663e\u793a\u4e86\u6fc0\u52a8\u6d3b\u6027\uff08EC50 = 210 nM\uff09\u3002\uff08\u8be6\u89c1WO 2018085170\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.5em;\"><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532925027.png\" alt=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\" title=\"\u3010BioWorld Science\u30112018\u5e746\u6708\u836f\u7269\u5feb\u8baf\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"  \/><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\">\u56fe\u4e3aWO 201808517<span style=\"line-height: 14.98px;color: windowtext;\">\u7684<\/span>\u7ed3\u6784<\/span><br  \/><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><br  \/><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><span style=\"font-size: 14px;line-height: 16.8px;color: windowtext;\"><br  \/><\/span><\/p>\n<p style=\"margin-top: 3px;margin-bottom: 5px;white-space: normal;text-align: center;line-height: 19.2px;background: white;\"><br  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 1px;background-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;color: rgb(0, 0, 0);\">\u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u5168\u90e8\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\u3002\u7f51\u7edc\u8f6c\u8f7d\u3001\u7f16\u8bd1\u53ca\u5176\u4ed6\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\u5e02\u573a\u90e8\uff1ayili1@Clarivate.com<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"padding: 10px;display: inline-block;width: 558px;border-width: 1px;border-style: solid;border-color: rgb(92, 11, 190);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\n<p style=\"text-align: center;box-sizing: border-box;\"><span style=\"font-size: 14px;\">Clarivate Analytics \u836f\u7269\u65b0\u95fb<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 0.2em;display: inline-block;float: left;width: 241.188px;border-width: 1px;border-style: dotted;border-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<section class=\"\" style=\"margin-top: 0.2em;display: inline-block;float: right;width: 241.188px;border-width: 1px;border-style: dotted;border-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<section class=\"\" style=\"margin: auto;width: 0.5em;height: 0.5em;box-sizing: border-box;\">\n<section style=\"transform: rotate(45deg);box-sizing: border-box;\">\n<section style=\"width: 0.5em;height: 0.5em;background-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;color: rgb(92, 11, 190);box-sizing: border-box;\">\u5468\u4e00\u81f3\u5468\u4e94\u52a8\u6001\u66f4\u65b0\u7684\u836f\u7269\u65b0\u95fb\u548cEMAIL\u8ddf\u8e2a\u63d0\u9192<br style=\"box-sizing: border-box;\"  \/><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\u25a0<\/span>&nbsp;&nbsp;<span style=\"font-size: 14px;\">\u6bcf\u5468\u4e00\u81f3\u4e94, Clarivate Analytics\u836f\u7269\u65b0\u95fb\uff08Clarivate Analytics BioWorld Science\uff09\u7cbe\u9009\u6700\u65b0\u3001\u6700\u91cd\u8981\u7684\u836f\u7269\u7814\u53d1\u65b0\u95fb\u5728\u7ebf\u53d1\u5e03\uff0c\u5e76\u4ee5\u7b80\u660e\u627c\u8981\u7684\u683c\u5f0f\u53d1\u9001\u63d0\u9192\u90ae\u4ef6\u81f3\u60a8\u7684\u90ae\u7bb1\uff0c\u5e2e\u52a9\u60a8\u5feb\u901f\u9501\u5b9a\u91cd\u8981\u7684\u65b0\u95fb\u4e8b\u4ef6\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\u25a0<\/span>&nbsp;&nbsp;\u60a8\u53ef\u4ee5\u5728\u7ebf\u68c0\u7d22\u6211\u4eec\u6240\u6709\u7684\u65b0\u95fb\u8d44\u6e90\uff0c\u5e76\u8bbe\u5b9a\u68c0\u7d22\u6761\u4ef6\uff08\u9650\u5b9a\u65b0\u95fb\u53d1\u751f\u7684\u65f6\u95f4\u3001\u836f\u540d\u3001\u4e13\u5229\u53f7\u3001\u516c\u53f8\u3001\u5927\u5b66\u3001\u673a\u6784\u3001\u6cbb\u7597\u7c7b\u522b\/\u5206\u7ec4\u3001\u5316\u5408\u7269\u7c7b\u578b\u3001\u4fe1\u606f\u6e90\uff09\u627e\u5230\u4e0e\u60a8\u7814\u7a76\u76f8\u5173\u7684\u5185\u5bb9\u3002\u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u5185\u5bb9\u53ef\u56de\u6eaf\u81f31996\u5e74\uff0c\u5e76\u53ef\u67e5\u770b\u5316\u5b66\u7ed3\u6784\u5f0f\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 0.2em;display: inline-block;float: left;width: 241.188px;border-width: 1px;border-style: dotted;border-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<section class=\"\" style=\"margin-top: 0.2em;display: inline-block;float: right;width: 241.188px;border-width: 1px;border-style: dotted;border-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<section class=\"\" style=\"margin: auto;width: 0.5em;height: 0.5em;box-sizing: border-box;\">\n<section style=\"transform: rotate(45deg);box-sizing: border-box;\">\n<section style=\"width: 0.5em;height: 0.5em;background-color: rgb(92, 11, 190);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;font-size: 14px;\">\u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u63d0\u4f9b\u5982\u4e0b\u5185\u5bb9\uff1a<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\u25a0<\/span>&nbsp;&nbsp;\u4ece\u6d77\u91cf\u4fe1\u606f\u6e90\u4e2d\u603b\u7ed3\u51fa\u7684\u6458\u8981\u62a5\u544a\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\u25a0<\/span>&nbsp;&nbsp;\u5728\u5168\u7403\u91cd\u8981\u4f1a\u8bae\u4e2d\u62ab\u9732\u7684\u65b0\u95fb\u4fe1\u606f\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\u25a0<\/span>&nbsp;&nbsp;\u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u4ee5\u8868\u683c\u7684\u5f62\u5f0f\u544a\u77e5\u60a8\u8fdb\u5165\u4e34\u5e8a\u524d\u5f00\u53d1\u6700\u6709\u524d\u666f\u7684\u5316\u5408\u7269\u3001lead compounds\u548c\u6700\u65b0\u7684\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"color: rgb(92, 11, 190);box-sizing: border-box;\">\u25a0<\/span>&nbsp;&nbsp;\u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u544a\u77e5\u60a8\u5728\u7814\u836f\u7269\u7814\u53d1\u72b6\u6001\u7684\u53d8\u66f4\u3002<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\">\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u79d1\u777f\u552f\u5b89\u751f\u547d\u79d1\u5b66\u4e0e\u5236\u836f                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb Drug Daily News\u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science \u5feb\u901f\u5bfc\u89c8 &#038;n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15267,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/15266"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=15266"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/15266\/revisions"}],"predecessor-version":[{"id":15280,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/15266\/revisions\/15280"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/15267"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=15266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=15266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=15266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}