{"id":15799,"date":"2018-07-15T01:00:00","date_gmt":"2018-07-31T02:44:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/31\/%e8%bf%91%e6%9c%9f2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e9%a2%86%e5%9f%9f%e7%a0%94%e7%a9%b6%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%81\/"},"modified":"2018-07-31T10:44:58","modified_gmt":"2018-07-31T02:44:58","slug":"%e8%bf%91%e6%9c%9f2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e9%a2%86%e5%9f%9f%e7%a0%94%e7%a9%b6%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/15799\/","title":{"rendered":"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1533005098.jpeg\" alt=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\" title=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u4e2d\uff0c\u5c0f\u7f16\u6574\u7406\u4e86\u8fd1\u671f\u79d1\u5b66\u5bb6\u4eec\u57282\u578b\u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u4e0e\u5927\u5bb6\u4e00\u8d77\u5b66\u4e60\uff01<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1533005098.jpeg\" alt=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\" title=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30101\u3011\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u8868\u660e\u7d22\u9a6c\u9c81\u80bd\u53ef\u4ee5\u66f4\u6709\u6548\u63a7\u52362\u578b\u7cd6\u5c3f\u75c5<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1111\/dom.13361<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6839\u636e\u4e00\u9879\u6700\u65b0\u53d1\u8868\u5728\u300aDiabetes\uff0c Obesity and Metabolism\u300b\u4e0a\u7684\u7efc\u8ff0\uff0c\u7d22\u9a6c\u9c81\u80bd\uff08Semaglutide\uff09\u53ef\u4ee5\u5b89\u5168\u6709\u6548\u7684\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6765\u81ea\u5e0c\u814a\u585e\u8428\u6d1b\u5c3c\u57fa\u4e9a\u91cc\u58eb\u591a\u5fb7\u5927\u5b66\u7684Panagiotis Andreadis\u535a\u58eb\u53ca\u5176\u540c\u4e8b\u5bf9\u6bd4\u8f83\u7d22\u9a6c\u9c81\u80bd\u548c\u5b89\u6170\u5242\u6216\u8005\u5176\u4ed6\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u884c\u4e86\u7cfb\u7edf\u7684\u7efc\u8ff0\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u6cbb\u7597\u7ed3\u675f\u540eHbA1c\u7684\u53d8\u5316\u6c34\u5e73\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u627e\u51fa\u4e866\u9879\u5b89\u6170\u5242\u63a7\u5236\u548c7\u9879\u9633\u6027\u836f\u7269\u63a7\u5236\u7684\u7814\u7a76\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u548c\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u76ae\u4e0b\u6ce8\u5c04\u7d22\u9a6c\u9c81\u80bd(0.5 and 1 mg)\u53ef\u4ee5\u5206\u522b\u5c06HbA1c\u6c34\u5e73\u964d\u4f4e1.01%\uff0895%\u7f6e\u4fe1\u533a\u95f4[CI]\uff0c0.56-1.47\uff09\u548c1.38%\uff0895%\u7f6e\u4fe1\u533a\u95f4[CI]\uff0c1.05-1.70\uff09\u3002\u4e0e\u5176\u4ed6\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\uff08\u897f\u4ed6\u5217\u6c40\u3001\u827e\u585e\u90a3\u80bd\u3001\u5229\u62c9\u9c81\u80bd\u3001\u5ea6\u62c9\u7cd6\u80bd\u3001\u7518\u7cbe\u80f0\u5c9b\u7d20\uff09\u76f8\u6bd4\uff0c\u7d22\u9a6c\u9c81\u80bd\u7684\u8840\u7cd6\u63a7\u5236\u6548\u679c\u66f4\u4f73\u3002\u540c\u65f6\uff0c\u4f7f\u7528\u7d22\u9a6c\u9c81\u80bd\u8fd8\u6709\u5229\u4e8e\u63a7\u5236\u4f53\u91cd\uff08\u548c\u5bf9\u7167\u7ec4\u76f8\u6bd4\u5e73\u5747\u5dee\u522b\u4e3a-4.11kg\uff0c95%\u7f6e\u4fe1\u533a\u95f4[CI]\uff0c-4.85- -2.27\uff09\u548c\u7cfb\u7edf\u8840\u538b\u3002\u4f46\u662f\u4f7f\u7528\u7d22\u9a6c\u9c81\u80bd\u4f1a\u4f7f\u6076\u5fc3\u3001\u5455\u5410\u548c\u8179\u6cfb\u98ce\u9669\u589e\u52a0\u3002\u548c\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u6982\u7387\u6bd4\u4e3a1.32 (95%\u7f6e\u4fe1\u533a\u95f4\uff0c 0.98-0.77).<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30102\u3011Nat Genet\uff1a\u673a\u4f53\u4e2d\u7279\u6b8a\u7684\u201c\u4f53\u578b\u201d\u57fa\u56e0\u6216\u4f1a\u589e\u52a0\u5973\u6027\u60a32\u578b\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1038\/s41588-018-0088-x<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u65e5\u524d\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature Genetics\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u725b\u6d25\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u5728\u5973\u6027\u673a\u4f53\u4e2d\u9274\u522b\u51fa\u4e86\u4e00\u79cd\u7279\u6b8a\u57fa\u56e0\u548c\u65b0\u578b\u8102\u80aa\u7ec6\u80de\u7684\u4ea7\u751f\u53ca\u5b9a\u4f4d\u76f4\u63a5\u76f8\u5173\uff0c\u968f\u540e\u8be5\u57fa\u56e0\u8fd8\u4f1a\u589e\u52a0\u5973\u6027\u4e2a\u4f53\u60a32\u578b\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u6d4b\u4e86KLF14\u57fa\u56e0\u7ed9\u673a\u4f53\u5065\u5eb7\u5e26\u6765\u7684\u6548\u5e94\uff0c\u4ed6\u4eec\u53d1\u73b0\uff0c\u63a7\u5236KLF14\u57fa\u56e0\u7684\u57fa\u56e0\u7a81\u53d8\u6216\u8bb8\u5bf9\u673a\u4f53\u6574\u4f53\u4f53\u91cd\u5f71\u54cd\u4e0d\u5927\uff0c\u4f46\u5374\u5bf9\u673a\u4f53\u4f53\u5185\u8102\u80aa\u50a8\u5b58\u7684\u90e8\u4f4d\u6709\u7740\u663e\u8457\u7684\u5f71\u54cd\uff0c\u5728\u5973\u6027\u673a\u4f53\u4e2d\uff0c\u8fd9\u79cd\u57fa\u56e0\u5e38\u5e38\u4f1a\u5bfc\u81f4\u8102\u80aa\u6709\u9650\u6c89\u79ef\u5728\u81c0\u90e8\u5468\u56f4\uff0c\u800c\u4e0d\u662f\u4e0b\u8179\u90e8\uff0c\u4ece\u800c\u5c31\u80fd\u4fdd\u62a4\u673a\u4f53\u62b5\u5fa1\u80a5\u80d6\u75c7\u7684\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">KLF14\u57fa\u56e0\u7684\u4e0d\u540c\u7a81\u53d8\u5e38\u5e38\u4f1a\u5f71\u54cd\u8102\u80aa\u7ec6\u80de\u7684\u53d1\u80b2\uff0c\u540c\u65f6\u8fd8\u4f1a\u5bf9\u8102\u80aa\u7ec6\u80de\u7684\u5c3a\u5bf8\u4ea7\u751f\u663e\u8457\u5f71\u54cd\uff0c\u5728\u643a\u5e26\u8be5\u57fa\u56e0\u7684\u5973\u6027\u673a\u4f53\u4e2d\uff0c\u8be5\u57fa\u56e0\u5e38\u5e38\u4f1a\u589e\u52a0\u4e2a\u4f53\u60a3\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\uff0c\u800c\u4e14\u5355\u4e00\u7684\u8102\u80aa\u7ec6\u80de\u5c3a\u5bf8\u8f83\u5927\uff0c\u4e14\u5145\u6ee1\u7740\u8102\u80aa\uff0c\u8fd9\u4f3c\u4e4e\u662f\u56e0\u4e3a\u8fd9\u6837\u7684\u7ec6\u80de\u5728\u4e00\u5f00\u59cb\u65f6\u6570\u91cf\u5c31\u6bd4\u8f83\u5c11\uff0c\u56e0\u6b64\u8fd9\u4e9b\u7ec6\u80de\u5e38\u5e38\u5728\u6700\u540e\u5c31\u4f1a\u5438\u6536\u66f4\u591a\u7684\u8102\u80aa\uff0c\u4ece\u800c\u5c31\u4f1a\u9020\u6210\u66f4\u591a\u65e0\u6548\u4e0d\u5065\u5eb7\u7684\u8102\u80aa\u7ec6\u80de\u4ea7\u751f\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e2a\u4f53\u66f4\u6613\u4e8e\u60a3\u4e0a\u7cd6\u5c3f\u75c5\u3002<\/span><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1533005098.jpeg\" alt=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\" title=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u30103\u30112\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u75c5\u673a\u7406\u5230\u5e95\u662f\u4ec0\u4e48\uff1f\u5982\u4f55\u6709\u6548\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u5462\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u65b0\u95fb\u9605\u8bfb\uff1aHave we got the causes of type 2 diabetes wrong\uff1f<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6709\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5168\u4e16\u754c\u60a3\u7cd6\u5c3f\u75c5\u7684\u6210\u5e74\u4eba\u6bd4\u4f8b\u4ece1980\u5e74\u76844.7%\u5df2\u7ecf\u4e0a\u5347\u5230\u4e86\u5982\u4eca\u76848.5%\u4e86\uff0c\u5982\u4eca\u7531\u8d85\u8fc74.22\u4ebf\u4eba\u90fd\u906d\u53d7\u7740\u7cd6\u5c3f\u75c5\u7684\u6298\u78e8\uff0c\u56e0\u6b64\u76ee\u524d\u7814\u7a76\u4eba\u5458\u6025\u9700\u7406\u89e3\u7cd6\u5c3f\u75c5\u7684\u53d1\u75c5\u673a\u7406\u5e76\u5f00\u53d1\u65b0\u578b\u7cd6\u5c3f\u75c5\u7597\u6cd5\uff1b\u8fd1\u65e5\uff0c\u4e00\u9879\u6765\u81ea\u5fb7\u56fd\u6d77\u5fb7\u5821\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u6216\u8bb8\u9610\u660e\u4e862\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u75c5\u539f\u56e0\uff0c\u90a3\u4e48\u8fd9\u662f\u5426\u610f\u5473\u7740\u672a\u6765\u80fd\u591f\u6539\u5584\u6211\u4eec\u5bf9\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u5462\uff1f<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u7cd6\u5c3f\u75c5\u60a3\u8005\u9700\u8981\u5bc6\u5207\u76d1\u6d4b\u5176\u673a\u4f53\u7684\u8840\u7cd6\u6c34\u5e73\uff0c\u8fd9\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u5176\u80fd\u5e2e\u52a9\u6709\u6548\u964d\u4f4e\u60a3\u8005\u5e76\u53d1\u75c7\u51fa\u73b0\u7684\u98ce\u9669\uff0c\u6bd4\u5982\u5fc3\u810f\u75c5\u548c\u5931\u660e\u7b49\uff0c\u4f46\u5373\u4f7f\u63a7\u5236\u4e86\u8840\u7cd6\u6c34\u5e73\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u901a\u5e38\u4e5f\u4f1a\u5728\u540e\u671f\u51fa\u73b0\u4e00\u4e9b\u5e76\u53d1\u75c7\uff0c\u5305\u62ec\u795e\u7ecf\u635f\u4f24\u548c\u80be\u810f\u635f\u4f24\u7b49\uff0c\u8fd9\u5c31\u8868\u660e\uff0c\u6709\u6548\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u7597\u6cd5\u5e76\u4e0d\u4ec5\u4ec5\u662f\u63a7\u5236\u60a3\u8005\u7684\u8840\u7cd6\u6c34\u5e73\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">2\u578b\u7cd6\u5c3f\u75c5\u901a\u5e38\u548c\u80a5\u80d6\u76f8\u5173\uff0c\u5f53\u80f0\u817a\u65e0\u6cd5\u91ca\u653e\u8db3\u591f\u7684\u80f0\u5c9b\u7d20\u6216\u673a\u4f53\u7ec6\u80de\u5bf9\u80f0\u5c9b\u7d20\u6ca1\u6709\u53cd\u5e94\u65f6\u90fd\u4f1a\u8bf1\u53d1\u7cd6\u5c3f\u75c5\u53d1\u751f\uff0c\u80f0\u5c9b\u7d20\u80fd\u591f\u5e2e\u52a9\u673a\u4f53\u5229\u7528\u8461\u8404\u7cd6\u6765\u4f5c\u4e3a\u5f53\u524d\u7684\u80fd\u91cf\u9700\u6c42\uff0c\u6216\u8005\u50a8\u5b58\u80fd\u91cf\u6765\u6ee1\u8db3\u672a\u6765\u7684\u80fd\u91cf\u9700\u6c42\uff0c\u8fd9\u5c31\u610f\u5473\u7740\uff0c\u8461\u8404\u7cd6\u80fd\u591f\u5728\u8840\u6db2\u4e2d\u505c\u7559\u800c\u65e0\u6cd5\u4f5c\u4e3a\u80fd\u91cf\uff0c\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5bf9\u4e8e\u5f15\u53d1\u8fd9\u4e9b\u7f3a\u9677\u7684\u539f\u56e0\u8fd8\u5b58\u5728\u4e00\u5b9a\u4e89\u8bae\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30104\u3011Nature\uff1a\u63ed\u793a\u8179\u90e8\u8102\u80aa\u4fc3\u8fdb2\u578b\u7cd6\u5c3f\u75c5\u4ea7\u751f\u4e4b\u8c1c<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1038\/nature26138<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8179\u90e8\u6df1\u5904\u7684\u8102\u80aa\u8981\u6bd4\u8eab\u4f53\u5176\u4ed6\u5730\u65b9\u7684\u8102\u80aa\u66f4\u591a\u5730\u589e\u52a0\u80f0\u5c9b\u7d20\u62b5\u6297\u6027\u548c2\u578b\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\u3002 \u4eba\u4eec\u5df2\u77e5\u5f53\u8179\u90e8\u8102\u80aa\u4ea7\u751f\u708e\u75c7\u65f6\uff0c\u5b83\u4f1a\u53d8\u5f97\u5371\u9669\uff0c\u4f46\u662f\u4eba\u4eec\u5f88\u96be\u786e\u5b9a\u662f\u4ec0\u4e48\u5f15\u8d77\u8fd9\u79cd\u708e\u75c7\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u63ed\u793a\u51fa\u5bfc\u81f4\u8fd9\u79cd\u795e\u79d8\u708e\u75c7\u7684\u81f3\u5c11\u4e00\u79cd\u7f6a\u9b41\u7978\u9996\u6765\u81ea\u809d\u810f\u3002\u4ed6\u4eec\u53d1\u73b0\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\uff0c\u809d\u810f\u589e\u52a0\u4e00\u79cd\u88ab\u79f0\u4f5cDPP4\u7684\u9176\u7684\u4ea7\u751f\u3002\u8fd9\u79cd\u9176\u901a\u8fc7\u8840\u6db2\u8fdb\u5165\u8179\u90e8\u8102\u80aa\u3002\u4e00\u65e6\u8fdb\u5165\u8179\u90e8\u7684\u8102\u80aa\u7ec4\u7ec7\uff0cDPP4\u534f\u52a9\u6fc0\u6d3b\u708e\u6027\u7ec6\u80de\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e743\u670821\u65e5\u5728\u7ebf\u53d1\u8868\u5728Nature\u671f\u520a\u4e0a\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u597d\u6d88\u606f\u662f\u6b63\u5982\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u5728\u5c0f\u9f20\u4e2d\u8bc1\u5b9e\u7684\u90a3\u6837\uff0c\u8fd9\u79cd\u708e\u75c7\u80fd\u591f\u901a\u8fc7\u5173\u95ed\u809d\u810f\u4e2d\u7684DPP4\u4ea7\u751f\u6765\u52a0\u4ee5\u7f13\u89e3\u3002\u5373\u4fbf\u8fd9\u4e9b\u5c0f\u9f20\u4ecd\u7136\u80a5\u80d6\uff0c\u7f13\u89e3\u8179\u90e8\u8102\u80aa\u4e2d\u7684\u708e\u75c7\u53ef\u6539\u5584\u5b83\u4eec\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u6027&#8212;2\u578b\u7cd6\u5c3f\u75c5\u7684\u6838\u5fc3\u95ee\u9898\u3002\u6b64\u5916\uff0c\u672a\u53d1\u8868\u7684\u6570\u636e\u8868\u660e\u8fd9\u79cd\u901a\u8def\u4e5f\u5b58\u5728\u4e8e\u4eba\u4f53\u4e2d\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bb8\u591a2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u53e3\u670dDPP4\u6291\u5236\u5242\uff08\u88ab\u79f0\u4f5cgliptin\uff09\u6765\u534f\u52a9\u63a7\u5236\u4ed6\u4eec\u7684\u75be\u75c5\u3002\u8fd9\u4e9b\u836f\u7269\u901a\u8fc7\u963b\u6b62DPP4\u5e72\u6270\u4e00\u79cd\u523a\u6fc0\u80f0\u5c9b\u7d20\u4ea7\u751f\u7684\u6fc0\u7d20\u6765\u964d\u4f4e\u8840\u7cd6\u3002\u4f46\u662f\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u4ee4\u4eba\u5403\u60ca\u5730\u53d1\u73b0\u8fd9\u4e9b\u836f\u7269\u5bf9\u80a5\u80d6\u5c0f\u9f20\u8179\u90e8\u8102\u80aa\u4e2d\u7684\u708e\u75c7\u6ca1\u6709\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1533005098.jpeg\" alt=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\" title=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30105\u3011JCI\uff1a\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u6f5c\u5728\u65b0\u836f<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1172\/JCI94330<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">2\u578b\u7cd6\u5c3f\u75c5\u53d1\u5c55\u5230\u5b8c\u5168\u7684\u9ad8\u8840\u7cd6\u72b6\u6001\u4e0e\u4e24\u4e2a\u4e3b\u8981\u7684\u75c5\u7406\u7f3a\u9677\u6709\u5173\uff1a\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u03b2\u7ec6\u80de\u529f\u80fd\u5931\u8c03\u3002\u4e4b\u524d\u7684\u7814\u7a76\u66fe\u7ecf\u53d1\u73b0CX3CL1\uff08fractalkine\uff0cFKN\uff09\u80de\u5916\u7ed3\u6784\u57df\u53d1\u751f\u86cb\u767d\u6c34\u89e3\u5207\u5272\u4e4b\u540e\u5f62\u6210\u4e00\u4e2a\u591a\u80bd\u80fd\u591f\u91ca\u653e\u5165\u8840\uff0c\u5e76\u4e14\u5df2\u7ecf\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u8840\u6db2\u4e2d\u68c0\u6d4b\u5230\u8fd9\u79cd\u8d8b\u5316\u56e0\u5b50\u3002FKN\u7684\u4f5c\u7528\u53d1\u6325\u4e3b\u8981\u7531\u5176\u540c\u6e90\u53d7\u4f53CX3CR1\u6240\u4ecb\u5bfc\u3002\u4e4b\u524d\u4e00\u9879\u7814\u7a76\u66fe\u53d1\u73b0CX3CR1\u6572\u9664\u5c0f\u9f20\u8868\u73b0\u51fa\u8461\u8404\u7cd6\u4e0d\u8010\u53d7\u7684\u8868\u578b\uff0c\u4e3b\u8981\u539f\u56e0\u662f\u03b2\u7ec6\u80de\u7684\u529f\u80fd\u5931\u6d3b\uff0cFKN\u6cbb\u7597\u80fd\u591f\u589e\u5f3a\u8461\u8404\u7cd6\u8010\u53d7\u6027\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u6700\u8fd1\u53d1\u8868\u5728\u56fd\u9645\u5b66\u672f\u671f\u520aJCI\u4e0a\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u7f13\u6162\u7ed9\u4e88\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b\u4e00\u79cd\u957f\u6548\u7684FKN\u2014\u2014FKN-Fc\u80fd\u591f\u53d1\u6325\u66f4\u52a0\u6301\u4e45\u7684\u4f5c\u7528\uff0c\u6539\u5584\u8461\u8404\u7cd6\u8010\u53d7\u6027\uff0c\u589e\u52a0\u8461\u8404\u7cd6\u523a\u6fc0\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u5e76\u6291\u5236\u03b2\u7ec6\u80de\u51cb\u4ea1\u3002\u4ee4\u4eba\u610f\u5916\u7684\u662f\uff0c\u7f13\u6162\u7684FKN-Fc\u6cbb\u7597\u4e5f\u4f1a\u6291\u5236\u03b1\u7ec6\u80de\u5206\u6ccc\u80f0\u9ad8\u8840\u7cd6\u7d20\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30106\u3011Cell\uff1a\u91cd\u78c5\uff01\u79d1\u5b66\u5bb6\u63ed\u793a\u8bf1\u53d12\u578b\u7cd6\u5c3f\u75c5\u7684\u5206\u5b50\u673a\u5236 \u6bd2\u6027\u86cb\u767d\u8d28\u5728\u4f5c\u602a\uff01<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1016\/j.cell.2018.02.026<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5168\u7403\u51e0\u4e4e\u67095\u4ebf\u4eba\u90fd\u60a3\u67092\u578b\u7cd6\u5c3f\u75c5\uff0c\u7136\u800c\u5c3d\u7ba1\u8fd9\u79cd\u75be\u75c5\u7684\u5f71\u54cd\u5f88\u5927\uff0c\u7136\u800c\u7814\u7a76\u4eba\u5458\u5e76\u4e0d\u6e05\u695a\u8be5\u75c5\u7684\u5177\u4f53\u53d1\u75c5\u539f\u56e0\uff0c\u5f53\u524d\u79d1\u5b66\u754c\u8ba4\u4e3a\u6709\u4e24\u4e2a\u5173\u952e\u7684\u81f4\u75c5\u8fc7\u7a0b\uff0c\u5373\u80f0\u5c9b\u7d20\u8010\u53d7\u6027\u548c\u03b2\u7ec6\u80de\u7684\u7834\u574f\uff0c\u524d\u8005\u662f\u7ec6\u80de\u4ea7\u751f\u4e86\u591a\u79cd\u65b9\u6cd5\u6765\u5173\u95ed\u80f0\u5c9b\u7d20\u4fe1\u53f7\uff0c\u800c\u540e\u8005\u5219\u662f\u80f0\u817a\u4e2d\u4ea7\u751f\u80f0\u5c9b\u7d20\u7684\u03b2\u7ec6\u80de\u88ab\u7834\u574f\u4e86\uff1b\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5e76\u4e0d\u6e05\u695a\u4e0a\u8ff0\u4e24\u79cd\u8fc7\u7a0b\u6240\u6d89\u53ca\u7684\u5206\u5b50\u673a\u5236\u3002<\/span><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Cell\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u6000\u7279\u9ed1\u5fb7\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\u4e86\u4e00\u79cd\u5f02\u5e38\u7684\u86cb\u767d\u8d28\u6c89\u79ef\u7269\u6216\u8bb8\u4f1a\u5728\u03b2\u7ec6\u80de\u4e2d\u79ef\u7d2f\u6270\u4e71\u5176\u6b63\u5e38\u529f\u80fd\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u7c7b\u4f3c\u4e8e\u8bf8\u5982\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u7b49\u795e\u7ecf\u53d8\u6027\u75be\u75c5\u4e2d\u51fa\u73b0\u7684\u86cb\u767d\u8d28\uff1b\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9610\u660e\u4e86\u540d\u4e3aSte24\u5173\u952e\u86cb\u767d\u7684\u529f\u80fd\uff0c\u8be5\u86cb\u767d\u80fd\u591f\u5e2e\u52a9\u758f\u901a\u7ec6\u80de\u5668\uff0c\u4fc3\u8fdb\u86cb\u767d\u8d28\u5728\u4e0d\u540c\u7ec6\u80de\u5668\u95f4\u7a7f\u68ad\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0c\u8fd9\u79cd\u758f\u901a\u4f5c\u7528\u6216\u8bb8\u80fd\u591f\u6709\u6548\u964d\u4f4e\u6216\u6291\u5236\u635f\u4f24\u03b2\u7ec6\u80de\u7684\u86cb\u767d\u8d28\u5728\u7ec6\u80de\u4e2d\u8fdb\u884c\u79ef\u7d2f\u3002<\/span><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1533005098-1.jpeg\" alt=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\" title=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30107\u3011Science\uff1a\u91cd\u78c5\uff01\u6211\u56fd\u79d1\u5b66\u5bb6\u8bc1\u5b9e\u9ad8\u7ea4\u7ef4\u81b3\u98df\u53ef\u6539\u55842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u5065\u5eb7<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1126\/science.aao5774<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6839\u636e\u4e00\u9879\u5f00\u521b\u6027\u7684\u9ad8\u7ea4\u7ef4\u81b3\u98df\u7814\u7a76\uff0c\u57282\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0c\u5229\u7528\u5bcc\u542b\u591a\u79cd\u7ea4\u7ef4\u7684\u81b3\u98df\u4fc3\u8fdb\u7279\u5b9a\u7684\u4e00\u7ec4\u80a0\u9053\u7ec6\u83cc\u751f\u957f\u4f1a\u5bfc\u81f4\u66f4\u597d\u7684\u8840\u7cd6\u63a7\u5236\u3001\u66f4\u5927\u7684\u4f53\u91cd\u51cf\u8f7b\u548c\u66f4\u597d\u7684\u8102\u8d28\u6c34\u5e73\u3002\u8fd9\u4e00\u53d1\u73b0\u53ef\u80fd\u5f88\u5feb\u4f1a\u6539\u5584\u5bf92\u578b\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u3002\u8fd9\u9879\u7814\u7a76\u662f\u6765\u81ea\u4e2d\u56fd\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u3001\u4e0a\u6d77\u5e02\u677e\u6c5f\u533a\u6cd7\u6cfe\u533b\u9662\u3001\u4e0a\u6d77\u5e02\u677e\u6c5f\u533a\u6cd7\u6cfe\u9547\u793e\u533a\u536b\u751f\u670d\u52a1\u4e2d\u5fc3\u3001\u6c5f\u82cf\u7701\u542f\u4e1c\u5e02\u4eba\u6c11\u533b\u9662\u548c\u9646\u519b\u519b\u533b\u5927\u5b66\uff08\u7b2c\u4e09\u519b\u533b\u5927\u5b66\uff09\u7684\u7814\u7a76\u4eba\u5458\u5f00\u5c55\u7684\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e743\u67089\u65e5\u7684Science\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cGut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes\u201d\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u9879\u5df2\u5f00\u5c556\u5e74\u7684\u7814\u7a76\u63d0\u4f9b\u8bc1\u636e\u6765\u8bc1\u5b9e\u5403\u66f4\u591a\u7684\u5408\u9002\u7684\u81b3\u98df\u7ea4\u7ef4\u53ef\u80fd\u8ba9\u80a0\u9053\u83cc\u7fa4\u6216\u8005\u8bf4\u8ba9\u80c3\u80a0\u9053\u4e2d\u7684\u7ec6\u83cc\u751f\u6001\u7cfb\u7edf\u91cd\u65b0\u6062\u590d\u5e73\u8861\uff0c\u8fd9\u6709\u52a9\u4e8e\u6d88\u5316\u98df\u7269\u5e76\u4e14\u5bf9\u4eba\u4f53\u7684\u6574\u4f53\u5065\u5eb7\u662f\u6bd4\u8f83\u91cd\u8981\u7684\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8d75\u7acb\u5e73\u6559\u6388\u8bf4\uff0c\u201c\u6211\u4eec\u7684\u7814\u7a76\u4e3a\u9776\u5411\u8fd9\u7ec4\u80a0\u9053\u7ec6\u83cc\u7684\u81b3\u98df\u7ea4\u7ef4\u53ef\u80fd\u6700\u7ec8\u6210\u4e3a\u4f60\u7684\u996e\u98df\u548c\u4f60\u7684\u6cbb\u7597\u65b9\u6cd5\u4e2d\u7684\u4e00\u4e2a\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u5960\u5b9a\u57fa\u7840\u548c\u63d0\u4f9b\u4e86\u53ef\u80fd\u6027\u3002\u201d<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">2\u578b\u7cd6\u5c3f\u75c5\u662f\u6700\u5e38\u89c1\u7684\u8870\u5f31\u6027\u75be\u75c5\u4e4b\u4e00\u3002\u5f53\u80f0\u817a\u4ea7\u751f\u8fc7\u5c11\u7684\u80f0\u5c9b\u7d20&#8212;\u4e00\u79cd\u534f\u52a9\u8461\u8404\u7cd6\u8fdb\u5165\u7ec6\u80de\u4e2d\u7528\u4f5c\u80fd\u91cf\u7684\u6fc0\u7d20&#8212;\u6216\u8005\u8eab\u4f53\u4e0d\u80fd\u5f88\u597d\u5730\u4f7f\u7528\u80f0\u5c9b\u7d20\u65f6\uff0c\u8fd9\u79cd\u75be\u75c5\u5c31\u4f1a\u4ea7\u751f\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30108\u3011Cell Metab\uff1a\u7814\u7a76\u63ed\u79d82\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e0d\u80fd\u6b63\u5e38\u5206\u6ccc\u80f0\u5c9b\u7d20\u7684\u539f\u56e0\uff01<\/span><\/strong><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1016\/j.cmet.2017.12.017<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u4e00\u9879\u65b0\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e4c\u666e\u8428\u62c9\u5927\u5b66\u4e0e\u9686\u5fb7\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5c55\u793a\u4e86\u4e3a\u4ec0\u4e482\u578b\u7cd6\u5c3f\u75c5\u4eba\u4e0d\u80fd\u6b63\u5e38\u5206\u6ccc\u80f0\u5c9b\u7d20\u3002\u8fd9\u9879\u7814\u7a76\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u300aCell Metabolism\u300b\u4e0a\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">2\u578b\u7cd6\u5c3f\u75c5\u662f\u5168\u7403\u7684\u4e3b\u8981\u516c\u5171\u536b\u751f\u95ee\u9898\uff0c\u5168\u7403\u5df2\u7ecf\u6709\u8d85\u8fc74\u4ebf\u4eba\u60a3\u8be5\u75be\u75c5\u3002\u751f\u6d3b\u4e60\u60ef\u548c\u9057\u4f20\u56e0\u7d20\u90fd\u4f1a\u5bfc\u81f4\u60a3\u8be5\u75be\u75c5\u3002\u8be5\u75be\u75c5\u7684\u4e3b\u8981\u95ee\u9898\u662f\u964d\u8840\u7cd6\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u4e0d\u8db3\uff0c\u80f0\u5c9b\u7d20\u7531\u80f0\u817a\u4e2d\u7684beta\u7ec6\u80de\u4ea7\u751f\u5e76\u5206\u6ccc\u5230\u8840\u6db2\u4e2d\u3002\u4e00\u4e2a\u7531\u4e4c\u666e\u8428\u62c9\u5927\u5b66Sebastian Barg\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u73b0\u5728\u53d1\u73b0\u8fd9\u662f\u7531\u4e8e\u80f0\u5c9b\u7d20\u5305\u88c5\u5e76\u8f93\u9001\u5230beta\u7ec6\u80de\u5916\u7684\u8fc7\u7a0b\u88ab\u6291\u5236\u3002\u5f53\u542b\u6709\u80f0\u5c9b\u7d20\u7684\u5c0f\u6ce1\u4e0e\u7ec6\u80de\u819c\u878d\u5408\u65f6\uff0c\u80f0\u5c9b\u7d20\u4f1a\u88ab\u5206\u6ccc\u5e76\u8fdb\u5165\u8840\u6db2\u4e2d\u3002\u4e3a\u4e86\u8fbe\u5230\u8fd9\u4e2a\u76ee\u7684\uff0c\u6bcf\u4e2a\u5c0f\u6ce1\u90fd\u5fc5\u987b\u5148\u5230\u7ec6\u80de\u819c\u7ec4\u88c5\u6210\u80f0\u5c9b\u7d20\u5206\u6ccc\u4f53\uff0c\u6b64\u540e\u80f0\u5c9b\u7d20\u624d\u80fd\u88ab\u5206\u6ccc\u53d1\u6325\u6548\u5e94\u3002<\/span><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1533005098-1.jpeg\" alt=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\" title=\"\u8fd1\u671f2\u578b\u7cd6\u5c3f\u75c5\u9886\u57df\u7814\u7a76\u65b0\u8fdb\u5c55\uff01\"  \/><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u30109\u3011J Clin Periodontol\uff1a\u4fdd\u6301\u53e3\u8154\u5065\u5eb7\u6216\u80fd\u6709\u6548\u6539\u55842\u578b\u7cd6\u5c3f\u75c5\u75c7\u72b6<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1111\/jcpe.12858<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Journal of Clinical Periodontology\u4e0a\u9898\u4e3a\u201cBenefits of nonsurgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis\uff1a a randomized controlled trial\u201d\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5df4\u585e\u7f57\u90a3\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u5f532\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u6ce8\u610f\u53e3\u8154\u536b\u751f\u65f6\uff0c\u5176\u7cd6\u5c3f\u75c5\u75c7\u72b6\u6216\u8bb8\u5c31\u80fd\u5f97\u5230\u6709\u6548\u6539\u5584\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u901a\u5e38\u4f1a\u4f34\u968f\u7259\u5468\u75be\u75c5\uff0c\u7814\u7a76\u8005Miquel Vinas\u8868\u793a\uff0c\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u4e0d\u4ec5\u53d1\u73b0\u4e86\u4ece\u7cd6\u5c3f\u75c5\u5230\u7259\u5468\u75be\u75c5\u7684\u8fc7\u7a0b\u4ee5\u53ca\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u7684\u5173\u8054\uff0c\u8fd8\u53d1\u73b0\u4e86\u60a3\u8005\u4ece\u7259\u5468\u75be\u75c5\u5411\u7cd6\u5c3f\u75c5\u8fc7\u6e21\u7684\u7ebf\u7d22\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u301010\u3011Nature\uff1a\u91cd\u78c5\uff01\u4e2d\u56fd\u79d1\u5b66\u5bb6\u6210\u529f\u89e3\u6790\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\u7ed3\u6784 \u6709\u671b\u5f00\u53d1\u51fa2\u578b\u7cd6\u5c3f\u75c5\u65b0\u578b\u7597\u6cd5<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">doi\uff1a10.1038\/nature25153<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 5px;padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(76, 76, 76);font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">B\u7c7bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCRs\uff09\u5728\u673a\u4f53\u6fc0\u7d20\u7a33\u6001\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u540c\u65f6\u5176\u4e5f\u662f\u591a\u79cd\u7c7b\u578b\u75be\u75c5\u7684\u91cd\u8981\u6cbb\u7597\u9776\u70b9\uff0c\u6bd4\u59822\u578b\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u8fd9\u4e9b\u53d7\u4f53\u5305\u62ec\u80de\u5916\u7ed3\u6784\u57df\uff08ECD\uff09\u548c\u8de8\u819c\u7ed3\u6784\u57df\uff08TMD\uff09\uff0c\u8fd9\u4e24\u4e2a\u533a\u57df\u90fd\u9700\u8981\u4e0e\u5176\u540c\u6e90\u591a\u80bd\u914d\u4f53\u76f8\u4e92\u4f5c\u7528\u6765\u8c03\u8282\u4e0b\u6e38\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u7531\u4e8e\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5f88\u96be\u5236\u5907\u51fa\u9ad8\u8d28\u91cf\u7684\u86cb\u767d\u8d28\uff0c\u56e0\u6b64\u5bf9\u4e8e\u79d1\u5b66\u5bb6\u4eec\u800c\u8a00\uff0c\u786e\u5b9aB\u7c7bGPCRs\u7684\u5168\u957f\u7ed3\u6784\u76ee\u524d\u4ecd\u7136\u662f\u4e00\u5927\u6311\u6218\uff0c\u540c\u65f6\u8fd9\u4e5f\u9650\u5236\u4e86\u7814\u7a76\u4eba\u5458\u5bf9\u53d7\u4f53\u4f5c\u7528\u5206\u5b50\u673a\u5236\u7684\u7406\u89e3\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u901a\u8fc7\u5185\u6e90\u6027\u914d\u4f53\u80f0\u9ad8\u8840\u7cd6\u7d20\u6fc0\u6d3b\u4eba\u7c7b\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08GCGR\uff09\u5c31\u80fd\u591f\u8bf1\u53d1\u673a\u4f53\u5728\u7981\u98df\u671f\u95f4\u4ece\u809d\u810f\u4e2d\u91ca\u653e\u8461\u8404\u7cd6\uff0c\u8fd9\u6216\u8bb8\u5c31\u80fd\u4f5c\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\uff1b\u53bb\u5e74\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u786e\u5b9a\u4e86\u7ed3\u5408\u5230\u8d1f\u53d8\u6784\u8c03\u5236\u5668NNC0640\u53ca\u6291\u5236\u6027\u6297\u4f53mAb1\u4e0a\u7684GCGR\u7684\u5168\u957f\u6676\u4f53\u7ed3\u6784\uff0c\u4ece\u800c\u9996\u6b21\u5728\u9ad8\u5206\u8fa8\u7387\u6761\u4ef6\u4e0b\u63ed\u793a\u4e86B\u7c7bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\u7684\u5168\u957f\u6e05\u6670\u56fe\u50cf\u3002<\/span><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u786e\u5b9a\u4e86GCGR\u8fde\u540c\u80f0\u9ad8\u8840\u7cd6\u7d20\u7c7b\u4f3c\u7269\u53ca\u90e8\u5206\u6fc0\u52a8\u5242NNC1702\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u8be5\u6676\u4f53\u7ed3\u6784\u9996\u6b21\u5c55\u793a\u4e86B\u7c7bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\u5728\u9ad8\u5206\u8fa8\u7387\u4e0b\u7ed3\u5408\u5176\u80bd\u7c7b\u914d\u4f53\u7684\u5206\u5b50\u7ec6\u8282\uff0c\u540c\u65f6\u7814\u7a76\u8005\u8fd8\u610f\u5916\u5730\u53d1\u73b0\u4e86\u63a7\u5236\u53d7\u4f53\u6fc0\u6d3b\u7684\u7ed3\u6784\u590d\u6742\u7279\u6027\uff0c\u4ece\u800c\u4e5f\u6269\u5c55\u4e86\u5bf9B\u7c7bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\u4fe1\u53f7\u8f6c\u5bfc\u8fc7\u7a0b\u7684\u7406\u89e3\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u2014\u2014 The End \u2014\u2014<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;text-decoration: underline;color: rgb(120, 172, 254);box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231167&amp;idx=1&amp;sn=28235cb4fd7bb283cf83af16cc7d3a42&amp;chksm=84be7824b3c9f132888169756d6229bda5f6942392c2d5adf0678a7bd053afa3b48bf35d379d&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(120, 172, 254);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/a><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652230701&amp;idx=1&amp;sn=ea702ea398a915207c0901323d96697a&amp;chksm=84be79f6b3c9f0e08013a45f74ccb18f77b2470d83a0b6a500591ffc2970fa796b24166bd325&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(120, 172, 254);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865 &nbsp;\u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231162&amp;idx=1&amp;sn=7b4cf87e991464cf2205db0c1293d26f&amp;chksm=84be7821b3c9f13739102fa0302f2743f323e9c92658af76d99cd548cb37cba12cd3c96b1193&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(120, 172, 254);box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231395&amp;idx=1&amp;sn=82b2e145bdd8711af2f6c8893456540f&amp;chksm=84be7b38b3c9f22e034b9d2e1eac88905f0d7157281960b676a50e597de212fc8af967145eb2&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&amp;\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/a><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231751&amp;idx=1&amp;sn=dce65e202747c083d07e8f2a0f1afea1&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6211\u4eec\u7684\u6bd5\u4e1a\u5b63<\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\n<p style=\"padding-right: 1em;padding-left: 1em;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><br  \/><\/p>\n<p><span style=\"max-width: 100%;font-size: 15px;color: rgb(76, 76, 76);box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6c47\u805a\u5357\u836f                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u6587\u4e2d\uff0c\u5c0f\u7f16\u6574\u7406\u4e86\u8fd1\u671f\u79d1\u5b66\u5bb6\u4eec\u57282\u578b\u7cd6\u5c3f\u75c5\u7814\u7a76\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u4e0e\u5927\u5bb6\u4e00\u8d77\u5b66\u4e60\uff01 \u30101\u3011\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u8868\u660e\u7d22\u9a6c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15800,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/15799"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=15799"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/15799\/revisions"}],"predecessor-version":[{"id":15807,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/15799\/revisions\/15807"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/15800"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=15799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=15799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=15799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}